ARFGEF1 Gene
protein-coding GIFtS: 53
GCID: GC08M068085
|
|
ADP-ribosylation factor guanine nucleotide-exchange factor...
| |
Aliases
for ARFGEF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 1 (BrefeldinA-Inhibited)1 2 | | P2002 5 | | ARFGEP11 2 3 5 | | Brefeldin A-Inhibited Guanine Nucleotide-Exchange Protein 12 | | BIG11 2 3 5 | | ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 13 | | P200 ARF Guanine Nucleotide Exchange Factor2 3 | | Brefeldin A-Inhibited GEP 13 | | P2002 5 | | P200 ARF-GEP13 | | DKFZP434L0571 | | |
Export aliases for ARFGEF1 gene to outside databasesPrevious GC identifers: GC08M068272 GC08M068109 GC08M063601 |
Summaries
for ARFGEF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ARFGEF1:
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded bythis gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. (providedby RefSeq, Aug 2011)
UniProtKB/Swiss-Prot: BIG1_HUMAN, Q9Y6D6Function: Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 throughreplacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; thefunction may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involvedin the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to actas A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity ofMYO9B probably through competetive RhoA binding. The function in the nucleus remains to be determined
Gene Wiki entry for ARFGEF1
|
Genomic Views
for ARFGEF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008183.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ARFGEF1 gene promoter:
AhR Pbx1a p300 AP-4 XBP-1 LCR-F1 GATA-1 GATA-2 Pax-3
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARFGEF1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARFGEF1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q13 Ensembl cytogenetic band: 8q13.2 HGNC cytogenetic band: 8q13ARFGEF1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M068085: view genomic region
(about GC identifiers)
Start:
|
68,085,747 bp from pter |
End:
|
68,255,912 bp from pter |
Size:
|
170,166 bases |
Orientation:
|
minus strand |
|
Proteins
for ARFGEF1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BIG1_HUMAN, Q9Y6D6 (See
protein sequence)Recommended Name: Brefeldin A-inhibited guanine nucleotide-exchange protein 1 Size: 1849 amino acids; 208767 Da
Subunit: Homodimer (Probable). Interacts with BIG1; both proteins are probably part of the same or very similarmacromolecular complexes. Interacts with FKBP2, DPY30, MYO9B, PRKAR1A, PRKAR2A, PPP1CC and PDE3A. Interacts withKANK1; however, colocalization cannot be experimentally confirmed. Interacts with NCL, FBL, NUP62 and U3 smallnucleolar RNA
Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network(By similarity). Nucleus. Nucleus, nucleolus. Nucleus matrix. Membrane. Note=Translocates from cytoplasm to membranesand nucleus upon cAMP treatment
1 PDB 3D structure from  and Proteopedia  for ARFGEF1:3LTL (3D)
Secondary accessions: Q9NV46 Q9UFV2 Q9UNL0Explore the universe of human proteins at neXtProt for ARFGEF1: NX_Q9Y6D6
Post-translational modifications:
Phosphorylated. In vitro phosphorylated by PKA reducing its GEF activity and dephosphorylated by phosphatase PP11
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y6D6
ARFGEF1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006412.2
ENSEMBL proteins: ENSP00000428429 ENSP00000262215 ENSP00000429560 ENSP00000430891 ENSP00000429138 ENSP00000429002
Human Recombinant Protein Products:
Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table
ARFGEF1 for ontologies About GeneDecksing
ARFGEF1 Antibody Products:
Assay Products for ARFGEF1: |
Protein
Domains /
Families
for ARFGEF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARFGEF1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y6D6ProtoNet protein and cluster: Q9Y6D6 1 Blocks protein family: IPB000904 SEC7-like domain
UniProtKB/Swiss-Prot: BIG1_HUMAN, Q9Y6D6Similarity: Contains 1 SEC7 domain |
Function
for ARFGEF1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BIG1_HUMAN, Q9Y6D6Function: Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 throughreplacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; thefunction may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involvedin the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to actas A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity ofMYO9B probably through competetive RhoA binding. The function in the nucleus remains to be determinedEnzyme regulation: Inhibited by brefeldin A
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARFGEF1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARFGEF1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARFGEF1 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
ARFGEF1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ARFGEF1:
|
Pathways & Interactions
for ARFGEF1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARFGEF1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/120 Interacting proteins for ARFGEF1 (Q9Y6D61, 2, 3 ENSP000002622154) via UniProtKB, MINT, STRING, and/or I2D (see all 120)About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table
ARFGEF1 for ontologies About GeneDecksing
|
Drugs & Compounds
for ARFGEF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ARFGEF1 for compounds About GeneDecksing
 Browse Tocris compounds for ARFGEF1
1 HMDB Compound for ARFGEF1 About this table
4 Novoseek chemical compound relationships for ARFGEF1 gene About this table
Search CenterWatch for drugs/clinical trials and news about ARFGEF1 / BIG1
|
Transcripts
for ARFGEF1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ARFGEF1 gene: NM_006421.4 Unigene Cluster for ARFGEF1: ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) Hs.656902 [show with all ESTs]Unigene Representative Sequence: NM_00642110 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000520381(uc003xxl.1) ENST00000522878 ENST00000262215(uc003xxn.2 uc003xxo.2)
ENST00000517743(uc003xxm.2) ENST00000518290(uc003xxp.1) ENST00000517955
ENST00000518789 ENST00000518230 ENST00000517631 ENST00000519436
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARFGEF1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARFGEF1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ARFGEF1 (NM_006421) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARFGEF1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARFGEF1 |
Additional cDNA sequence: AB209324.1 AF084520.1 AF111162.1 AK001788.1 AK022557.1 AK025637.1 AK123660.1 AK127799.1 AL117446.1 14 DOTS entries: DT.445793 DT.86839762 DT.75173739 DT.92040140 DT.100783795 DT.40195517 DT.423592 DT.40294649 DT.120640617 DT.92442947 DT.100783797 DT.92442946 DT.95361857 DT.102845213 24/177 AceView cDNA sequences (see all 177): CA314908 CA416114 AK127799 AA437147 BQ002823 AK022557 AL117446 CF136861 BP345693 AW135661 AA079468 AK123660 BM423360 CA395431 N92915 AI125675 BM424130 BE465243 BU146212 BM992140 BM923948 AA876416 BF437842 AI368789
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ARFGEF1 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32a | · | 32b | ^ | 33 | ^ | 34a | · | 34b | · | 34c | · | 34d | ^ | 35a | · | 35b | ^ | 36a | · | 36b | · | 36c | ^ | 37a | · | 37b | ^ | 38a | · | 38b | · | 38c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | - | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ARFGEF1
|
Expression
for ARFGEF1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARFGEF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTTGCGGAG
About this image
See ARFGEF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARFGEF1
SOURCE GeneReport for Unigene cluster: Hs.656902
UniProtKB/Swiss-Prot: BIG1_HUMAN, Q9Y6D6Tissue specificity: Expressed in placenta, lung, heart, brain, kidney and pancreas
SABiosciences Custom PCR Arrays for ARFGEF1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARFGEF1
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARFGEF1 |
Orthologs
for ARFGEF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ARFGEF1 gene from 9/34 species (see all 34) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ARFGEF11 |
ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) less |
84.59(n)
94.85(a) |
|
420170 XM_418283.3 XP_418283.3 |
lizard
(Anolis carolinensis) |
Reptilia |
ARFGEF16 |
-- |
94(a) |
1 ↔ 1 |
4(31174638-31243159) |
African clawed frog
(Xenopus laevis) |
Amphibia |
CF282946.12 |
-- |
93.02(n) |
|
CF282946.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufj64h082 |
Transcribed sequence with moderate similarity to protein spQ9Y6D6 (H.sapiens) BIG1_HUMAN Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor) less |
76.9(n) |
|
CA474608.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
sec711 |
CG7578-PA |
60.74(n)
68.1(a) |
|
34785 NM_135831.2 NP_609675.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
agef-11 |
Protein AGEF-1 |
54.07(n)
50(a) |
|
173231 NM_001136328.1 NP_001129800.1 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
SEC71 |
Sec7p |
45.82(n)
32.51(a) |
|
851748 NP_010454.3 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
EDA101 |
SEC7-like guanine nucleotide exchange protein |
50.06(n)
39.58(a) |
|
839301 NM_100076.2 NP_171698.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.105272 |
Oryza sativa guanine nucleotide-exchange protein GEP2 (GEP2) mRNA, partial cds less |
73.91(n) |
|
AF262215.1 |
ENSEMBL Gene Tree for ARFGEF1 (if available)
TreeFam Gene Tree for ARFGEF1 (if available) |
Paralogs
for ARFGEF1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ARFGEF1 gene
- PSD32 GBF12 CYTH32 IQSEC32 CYTH22 ARFGEF22 PSD42 IQSEC12
- PSD22 PSD2 IQSEC22 CYTH42 CYTH12 FBXO82
8 SIMAP similar genes for ARFGEF1 using alignment to 6 protein entries: BIG1_HUMAN (see all proteins):ARFGEF2 PSCD2L CYTH2 CYTH1 CYTH3 FLJ00017
CYTH4 MST051
ARFGEF1 for paralogs About GeneDecksing
|
Genomic Variants
for ARFGEF1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ARFGEF1 (68085747 - 68255912 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for ARFGEF1
6 CNVs: 8607 65157 95486 82637 100378 8606
1 Indel: 60710 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARFGEF1 |
|
Disorders
/ Diseases
for ARFGEF1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ARFGEF1 for disorders About GeneDecksing
OMIM gene information: 604141
OMIM disorders: --
7  diseases for ARFGEF1: About MalaCardsepidermolysis bullosa acquisita epidermolysis bullosa heart block congenital heart block
bullous pemphigoid rubella breast cancer
Human Genome Epidemiology (HuGE) Navigator: ARFGEF1 (2 documents)
Export disorders for ARFGEF1 gene to outside databases
|
Publications
for ARFGEF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARFGEF1 gene, integrated from 9 sources (see all 53):
(articles sorted by number of sources associating them with ARFGEF1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors. (PubMed id 10212200)1, 2, 3, 9 Togawa A.... Vaughan M. (1999)
- Effect of protein kinase A on accumulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) in HepG2 cell nuclei. (PubMed id 16467138)1, 2, 9 Citterio C....Vaughan M. (2006)
- Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma. (PubMed id 17360629)1, 2, 9 Kuroda F....Vaughan M. (2007)
- Nuclear localization and molecular partners of BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors. (PubMed id 14973189)1, 2, 9 Padilla P.I....Vaughan M. (2004)
- Association of guanine nucleotide-exchange protein BIG1 in HepG2 cell nuclei with nucleolin, U3 snoRNA, and fibrillarin. (PubMed id 18292223)1, 2, 9 Padilla P.I....Vaughan M. (2008)
- Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506. (PubMed id 12606707)1, 2, 9 Padilla P.I....Vaughan M. (2003)
- p200 ARF-GEP1: a Golgi-localized guanine nucleotide exchange protein whose Sec7 domain is targeted by the drug brefeldin A. (PubMed id 10393931)1, 2, 9 Mansour S.J....Melancon P. (1999)
- Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2). (PubMed id 12571360)1, 2, 9 Li H....Vaughan M. (2003)
- Effects of brefeldin A-inhibited guanine nucleotide-e xchange (BIG) 1 and KANK1 proteins on cell polarity and directed migration duri ng wound healing. (PubMed id 22084092)1, 2 Li C.C....Vaughan M. (2011)
- A role of histone H3 lysine 4 methyltransferase components in endosomal trafficking. (PubMed id 19651892)1, 2 Xu Z.... Ma D. (2009)
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External Searches for ARFGEF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing ARFGEF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing ARFGEF1 gene
(According to HUGE)
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Specialized Databases showing ARFGEF1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for ARFGEF1 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for ARFGEF1 gene:
Search GeneIP for patents involving ARFGEF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for ARFGEF1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ARFGEF1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARFGEF1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARFGEF1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ARFGEF1 | | OriGene 3'-UTR Clone for ARFGEF1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARFGEF1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARFGEF1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ARFGEF1 | | OriGene Custom Protein Services for ARFGEF1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARFGEF1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARFGEF1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARFGEF1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARFGEF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARFGEF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARFGEF1 |
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| | | | Search Tocris compounds for ARFGEF1 |
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 | | | ARFGEF1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARFGEF1 |
|  |  |  | | | | Search ThermoFisher Antibodies for ARFGEF1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARFGEF1 |
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