Aliases for ARFGEF1 Gene
- ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 1 (Brefeldin A-Inhibited) 2 3
- ARFGEP1 3 4 6
- BIG1 3 4 6
- P200 ARF Guanine Nucleotide Exchange Factor 3 4
- P200 3 6
- ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 1 4
- Brefeldin A-Inhibited Guanine Nucleotide-Exchange Protein 1 3
- Brefeldin A-Inhibited GEP 1 4
- P200 ARF-GEP1 4
External Ids for ARFGEF1 Gene
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Aug 2011]
GeneCards Summary for ARFGEF1 Gene
ARFGEF1 (ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 1 (Brefeldin A-Inhibited)) is a Protein Coding gene. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and myosin binding. An important paralog of this gene is ENSG00000268465.
UniProtKB/Swiss-Prot for ARFGEF1 Gene
Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competetive RhoA binding. The function in the nucleus remains to be determined.