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ARFGAP3 Gene

protein-coding   GIFtS: 54
GCID: GC22M043192

ADP-Ribosylation Factor GTPase Activating Protein 3

(Previous name: ADP-ribosylation factor GTPase activating protein 1)
(Previous symbol: ARFGAP1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADP-Ribosylation Factor GTPase Activating Protein 31 2
ARFGAP11 2 3
ADP-Ribosylation Factor GTPase Activating Protein 11 2
ARF GAP 32 3
ADP-Ribosylation Factor GTPase-Activating Protein 32

External Ids:    HGNC: 6611   Entrez Gene: 262862   Ensembl: ENSG000002422477   OMIM: 6124395   UniProtKB: Q9NP613   

Export aliases for ARFGAP3 gene to outside databases

Previous GC identifers: GC22M039795 GC22M041423 GC22M041517 GC22M026151


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARFGAP3 Gene:
The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and
regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation
factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes
and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target
compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding
different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the
name of a related but different gene. (provided by RefSeq, Nov 2008)

GeneCards Summary for ARFGAP3 Gene:
ARFGAP3 (ADP-ribosylation factor GTPase activating protein 3) is a protein-coding gene. Diseases associated with ARFGAP3 include breast and colorectal cancer, and colorectal cancer. GO annotations related to this gene include protein transporter activity and ARF GTPase activator activity. An important paralog of this gene is ARFGAP2.

UniProtKB/Swiss-Prot: ARFG3_HUMAN, Q9NP61
Function: GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may
lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes

summary for ARFGAP3 Gene:
Small G proteins (small GTPases) are homologous to Galpha proteins and are often referred to as the Ras
proto-oncogene superfamily. The Ras superfamily contains over 100 small GTPases grouped into eight families;
Ras, Rho, Rab, Rap, Arf, Ran, Rheb and Rad. Small GTPases regulate a wide variety of processes in the cell,
including growth, differentiation, movement and lipid vesicle transport.

Gene Wiki entry for ARFGAP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ARFGAP3 gene promoter:
         Nkx3-1   Sp1   Nkx3-1 v1   CUTL1   LCR-F1   Nkx3-1 v2   PPAR-gamma1   FOXO4   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARFGAP3 promoter sequence
   Search Chromatin IP Primers for ARFGAP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARFGAP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.2   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.2

ARFGAP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARFGAP3 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M043192:  view genomic region     (about GC identifiers)

Start:
43,192,508 bp from pter      End:
43,254,112 bp from pter
Size:
61,605 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ARFG3_HUMAN, Q9NP61 (See protein sequence)
Recommended Name: ADP-ribosylation factor GTPase-activating protein 3  
Size: 516 amino acids; 56928 Da
Developmental stage: Expressed at higher level in adult thymus, brain and lung, than in corresponding fetal
tissues. Expressed at lower level in spleen, heart, kidney and liver during development
Caution: Was originally (PubMed:10704287) termed ARFGAP1
Sequence caution: Sequence=BAA92076.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB14236.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for ARFGAP3:
2CRW (3D)    
Secondary accessions: E9PB03 Q9BSC6 Q9H9J0 Q9NT10 Q9NUP5 Q9Y4V3 Q9Y4V4
Alternative splicing: 2 isoforms:  Q9NP61-1   Q9NP61-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for ARFGAP3: NX_Q9NP61

Explore proteomics data for ARFGAP3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys392, Lys425, Lys467
  • Modification sites at PhosphoSitePlus

  • See ARFGAP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001135765.1  NP_055385.3  

    ENSEMBL proteins: 
     ENSP00000263245   ENSP00000388791   ENSP00000403995   ENSP00000403520   ENSP00000407734  
     ENSP00000393959  

    ARFGAP3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for ARFGAP3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ArfGAP: ADP-ribosylation factor GTPase activating proteins

    1 InterPro protein domain:
     IPR001164 ArfGAP

    Graphical View of Domain Structure for InterPro Entry Q9NP61

    ProtoNet protein and cluster: Q9NP61

    1 Blocks protein domain: IPB001164 HIV Rev interacting protein signature

    UniProtKB/Swiss-Prot: ARFG3_HUMAN, Q9NP61
    Similarity: Contains 1 Arf-GAP domain


    ARFGAP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARFG3_HUMAN, Q9NP61
    Function: GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may
    lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes
    Enzyme regulation: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008060ARF GTPase activator activity IDA11172815
    GO:0008270zinc ion binding IEA--
    GO:0008565protein transporter activity NAS11172815
         
    ARFGAP3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARFGAP3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARFGAP3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARFGAP3

    miRNA
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    miRTarBase miRNAs that target ARFGAP3:
    hsa-mir-93-3p (MIRT038823)

    Block miRNA regulation of human, mouse, rat ARFGAP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARFGAP3 (see all 12):
    hsa-miR-3618 hsa-miR-607 hsa-miR-1283 hsa-miR-4318 hsa-miR-520d-5p hsa-miR-3653 hsa-miR-4275 hsa-miR-338-5p
    SwitchGear 3'UTR luciferase reporter plasmidARFGAP3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARFGAP3

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    GenScript: all cDNA clones in your preferred vector (see all 2): ARFGAP3 (NM_014570)
    Sino Biological Human cDNA Clone for ARFGAP3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARFGAP3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARFGAP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARFG3_HUMAN, Q9NP61: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
    Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate
    compartment
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    golgi apparatus5
    nucleus3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005829cytosol IDA11172815

    ARFGAP3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARFGAP3 About    
    See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Paxillin Interactions0.73
    2PAK Pathway
    PAK Pathway0.56
    3Endocytosis
    Endocytosis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ARFGAP3
        Paxillin Interactions
    PAK Pathway



    1 Kegg Pathway  (Kegg details for ARFGAP3):
        Endocytosis


    ARFGAP3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARFGAP3
    Interactions:

        Search GeneGlobe Interaction Network for ARFGAP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARFGAP3 (Q9NP613 ENSP000002632454) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD2Q157963, ENSP000002621604I2D: score=4 STRING: ENSP00000262160
    CSNK1A1P487293I2D: score=1 
    COPB1ENSP000002499234STRING: ENSP00000249923
    COPG1ENSP000003250024STRING: ENSP00000325002
    COPB2ENSP000003294194STRING: ENSP00000329419
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport NAS11172815
    GO:0009306protein secretion IEP11172815
    GO:0016192vesicle-mediated transport NAS11172815
    GO:0032312regulation of ARF GTPase activity IEA--
    GO:0043547positive regulation of GTPase activity IDA11172815

    ARFGAP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ARFGAP3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    QS 11ARFGAP1 inhibitor; modulates Wnt/beta-catenin signaling[944328-88-5]
    NSC 23766Selective inhibitor of Rac1-GEF interaction; antioncogenic[733767-34-5]
    EHT 1864Potent inhibitor of Rac family GTPases[754240-09-0]
    SecinH3Sec7-specific GEF inhibitor (cytohesins)[853625-60-2]
    Rac1 Inhibitor W56Selective inhibitor of Rac1-GEF interaction[1095179-01-3]

    1 HMDB Compound for ARFGAP3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 Novoseek inferred chemical compound relationships for ARFGAP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 62.6 4 10788515 (1), 16093346 (1), 17253781 (1)
    zinc 22.9 3 10788515 (1), 10704287 (1)



    ARFGAP3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARFGAP3 gene (2 alternative transcripts): 
    NM_001142293.1  NM_014570.4  

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263245(uc003bdd.2 uc010gzf.2 uc011apu.1) ENST00000437119
    ENST00000453516 ENST00000454099 ENST00000435208 ENST00000493606 ENST00000429508

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ARFGAP3 (see all 12):
    hsa-miR-3618 hsa-miR-607 hsa-miR-1283 hsa-miR-4318 hsa-miR-520d-5p hsa-miR-3653 hsa-miR-4275 hsa-miR-338-5p
    SwitchGear 3'UTR luciferase reporter plasmidARFGAP3 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ARFGAP3
      QuantiFast Probe-based Assays in human, mouse, rat ARFGAP3

    Selected AceView cDNA sequences (see all 512):

    CD171838 BM757542 BM909881 AI401634 CK430211 BF979854 BM749809 BM757594 
    AA743892 BM827852 AA397450 BF115896 BM982147 AW338358 BP346018 AI554275 
    BM758341 BE047127 BM090836 NM_014570 BM750601 AA402698 CD369610 BM757730 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARFGAP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTCAGGGC
    ARFGAP3 Expression
    About this image

    ARFGAP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARFGAP3 Protein Expression

    UniProtKB/Swiss-Prot: ARFG3_HUMAN, Q9NP61
    Tissue specificity: Widely expressed. Highest expression in endocrine glands (pancreas, pituitary gland, salivary
    gland, and prostate) and testis with a much higher expression in the testis than in the ovary

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARFGAP3 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arfgap31 , 5 ADP-ribosylation factor GTPase activating protein 31, 5 79.52(n)1
    80.62(a)1
      15 (39.40 cM)5
    662511  NM_025445.41  NP_079721.21 
     832997405 
    chicken
    (Gallus gallus)
    Aves ARFGAP31 ADP-ribosylation factor GTPase activating protein 3 71.11(n)
    69.89(a)
      418224  NM_001012539.1  NP_001012557.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARFGAP36
    ADP-ribosylation factor GTPase activating protein ...
    69(a)
    1 ↔ 1
    5(86931948-86976919)
    African clawed frog
    (Xenopus laevis)
    Amphibia arfgap3-prov2 ADP-ribosylation factor GTPase activating protein 1 72.62(n)    BC041750.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arfgap36
    ADP-ribosylation factor GTPase activating protein ...
    48(a)
    1 ↔ 1
    4(62041782-62049681) ENSDARG00000097583
    fruit fly
    (Drosophila melanogaster)
    Insecta ArfGAP36
    ADP-ribosylation factor GTPase activating protein ...
    37(a)
    1 → many
    3L(22707413-22710677)
    worm
    (Caenorhabditis elegans)
    Secernentea F07F6.46
    Protein F07F6.4 (F07F6.4) mRNA, complete cds
    34(a)
    1 → many
    II(5425780-5429572) WBGene00017217
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GLO36
    ADP-ribosylation factor GTPase activating protein ...
    22(a)
    1 → many
    V(402871-404352) YER122C


    ENSEMBL Gene Tree for ARFGAP3 (if available)
    TreeFam Gene Tree for ARFGAP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARFGAP3 gene
    ARFGAP22  
    Selected SIMAP similar genes for ARFGAP3 using alignment to 5 protein entries:     ARFG3_HUMAN (see all proteins) (see all similar genes):
    ARFGAP2    ARFGAP1    SMAP1    DDEF2    ADAP1    ARAP3
    ASAP1    CENTG2    AGAP1    AGAP2    CENTG3    DKFZp761E2216
    AGAP3    FLJ00312    GIT1    AGAP11    AGAP8    ADAP2

    ARFGAP3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARFGAP3 (see all 1607)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361774
    A breast cancer sample4--see VAR_0361772 E G mis40--------
    rs576209301,2
    C--27137019(+) TTTTT-/TT/TTT
            
    AGAGA
    4 -- int1 cds11NA 2
    rs1876390101,2
    --43192164(+) AGGCAC/TATGCC 2 -- ds50010--------
    rs3775267521,2
    C--43192207(+) AGAGGC/TGGGTC 2 -- ds50010--------
    rs774345221,2
    C,F--43192208(+) GAGGCG/AGGGTC 2 -- ds50012Minor allele frequency- A:0.18WA 120
    rs1917074721,2
    --43192221(+) GCTGTA/GTTGTC 2 -- ds50010--------
    rs1466361421,2
    C--43192305(+) TGAGCC/TGCCTC 2 -- ds50010--------
    rs1831062991,2
    --43192325(+) AACATA/CCCCAT 2 -- ds50010--------
    rs1478919471,2
    --43192359(+) GCTCCC/TGTGCT 2 -- ds50010--------
    rs1488768741,2
    --43192394(+) CAACTA/GCACAG 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for ARFGAP3 (43192508 - 43254112 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ARFGAP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2549553CNV Insertion19546169
    nsv508738CNV Insertion20534489
    nsv915196CNV Loss21882294
    nsv915195CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612439    OMIM disorders: --

    4 diseases for ARFGAP3:    
    About MalaCards
    breast and colorectal cancer    colorectal cancer    prostate cancer    prostatitis


    ARFGAP3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARFGAP3
    Human Genome Epidemiology (HuGE) Navigator: ARFGAP3 (1 document)

    Export disorders for ARFGAP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARFGAP3 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with ARFGAP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional characterization of novel human ARFGAP3. (PubMed id 11172815)1, 2, 3, 9 Liu X.... He F. (FEBS Lett. 2001)
    2. Characterization, chromosomal assignment, and tissue expression of a novel human gene belonging to the ARF GAP family. (PubMed id 10704287)1, 2, 3, 9 Zhang C.... He F. (Genomics 2000)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Two human ARFGAPs associated with COP-I-coated vesicles. (PubMed id 17760859)1, 2 Frigerio G.... Duden R. (Traffic 2007)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    8. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PubMed id 12529303)1, 2 Collins J.E.... Dunham I. (Genome Res. 2003)
    9. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    10. Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking. (PubMed id 19015319)1, 9 Weimer C....Wieland F. (J. Cell Biol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 26286 HGNC: 661 AceView: PACSIN2andARFGAP3 Ensembl:ENSG00000242247 euGenes: HUgn26286
    ECgene: ARFGAP3 Kegg: 26286 H-InvDB: ARFGAP3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ARFGAP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ARFGAP3 gene:
    Search GeneIP for patents involving ARFGAP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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