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Aliases for ARFGAP3 Gene

Aliases for ARFGAP3 Gene

  • ADP-Ribosylation Factor GTPase Activating Protein 3 2 3
  • ADP-Ribosylation Factor GTPase Activating Protein 1 2 3
  • ARF GAP 3 3 4
  • ARFGAP1 3 4

External Ids for ARFGAP3 Gene

Previous HGNC Symbols for ARFGAP3 Gene

  • ARFGAP1

Previous GeneCards Identifiers for ARFGAP3 Gene

  • GC22M039795
  • GC22M041423
  • GC22M041517
  • GC22M043192
  • GC22M026151

Summaries for ARFGAP3 Gene

Entrez Gene Summary for ARFGAP3 Gene

  • The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene. [provided by RefSeq, Nov 2008]

GeneCards Summary for ARFGAP3 Gene

ARFGAP3 (ADP-Ribosylation Factor GTPase Activating Protein 3) is a Protein Coding gene. Among its related pathways are GPCR Pathway and PAK Pathway. GO annotations related to this gene include GTPase activator activity and protein transporter activity. An important paralog of this gene is ARFGAP2.

UniProtKB/Swiss-Prot for ARFGAP3 Gene

  • GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.

Tocris Summary for ARFGAP3 Gene

  • Small G proteins (small GTPases) are homologous to Galpha proteins and are often referred to as the Ras proto-oncogene superfamily. Small GTPases regulate a wide variety of processes in the cell, including growth, differentiation, movement and lipid vesicle transport.

Gene Wiki entry for ARFGAP3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARFGAP3 Gene

Genomics for ARFGAP3 Gene

Regulatory Elements for ARFGAP3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARFGAP3 Gene

Chromosome:
22
Start:
42,796,502 bp from pter
End:
42,858,106 bp from pter
Size:
61,605 bases
Orientation:
Minus strand

Genomic View for ARFGAP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARFGAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARFGAP3 Gene

Proteins for ARFGAP3 Gene

  • Protein details for ARFGAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP61-ARFG3_HUMAN
    Recommended name:
    ADP-ribosylation factor GTPase-activating protein 3
    Protein Accession:
    Q9NP61
    Secondary Accessions:
    • E9PB03
    • Q9BSC6
    • Q9H9J0
    • Q9NT10
    • Q9NUP5
    • Q9Y4V3
    • Q9Y4V4

    Protein attributes for ARFGAP3 Gene

    Size:
    516 amino acids
    Molecular mass:
    56928 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92076.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14236.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARFGAP3 Gene

    Alternative splice isoforms for ARFGAP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARFGAP3 Gene

Proteomics data for ARFGAP3 Gene at MOPED

Post-translational modifications for ARFGAP3 Gene

  • Ubiquitination at Lys 392, Lys 425, and Lys 467
  • Modification sites at PhosphoSitePlus

Other Protein References for ARFGAP3 Gene

Antibody Products

No data available for DME Specific Peptides for ARFGAP3 Gene

Domains & Families for ARFGAP3 Gene

Gene Families for ARFGAP3 Gene

HGNC:

Protein Domains for ARFGAP3 Gene

Suggested Antigen Peptide Sequences for ARFGAP3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NP61

UniProtKB/Swiss-Prot:

ARFG3_HUMAN :
  • Contains 1 Arf-GAP domain.
Domain:
  • Contains 1 Arf-GAP domain.
genes like me logo Genes that share domains with ARFGAP3: view

Function for ARFGAP3 Gene

Molecular function for ARFGAP3 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2).
UniProtKB/Swiss-Prot Function:
GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.

Gene Ontology (GO) - Molecular Function for ARFGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA 11172815
GO:0005515 protein binding IPI 24705354
GO:0008565 protein transporter activity NAS 11172815
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ARFGAP3: view

Phenotypes for ARFGAP3 Gene

GenomeRNAi human phenotypes for ARFGAP3:
genes like me logo Genes that share phenotypes with ARFGAP3: view

Animal Model Products

miRNA for ARFGAP3 Gene

miRTarBase miRNAs that target ARFGAP3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARFGAP3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ARFGAP3 Gene

Localization for ARFGAP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARFGAP3 Gene

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARFGAP3 Gene COMPARTMENTS Subcellular localization image for ARFGAP3 gene
Compartment Confidence
cytosol 5
golgi apparatus 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ARFGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IDA 11172815
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ARFGAP3: view

Pathways & Interactions for ARFGAP3 Gene

genes like me logo Genes that share pathways with ARFGAP3: view

Pathways by source for ARFGAP3 Gene

2 Qiagen pathways for ARFGAP3 Gene
1 Cell Signaling Technology pathway for ARFGAP3 Gene
1 BioSystems pathway for ARFGAP3 Gene

Gene Ontology (GO) - Biological Process for ARFGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport NAS 11172815
GO:0009306 protein secretion IEP 11172815
GO:0016192 vesicle-mediated transport NAS 11172815
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ARFGAP3: view

No data available for SIGNOR curated interactions for ARFGAP3 Gene

Drugs & Compounds for ARFGAP3 Gene

(4) Drugs for ARFGAP3 Gene - From: NovoSeek, Tocris, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1404
Guanosine triphosphate Experimental Pharma 0
EHT 1864 Pharma Rac family small GTPases inhibitor, Potent inhibitor of Rac family GTPases 0
NSC 23766 Pharma Selective inhibitor of Rac1-GEF interaction., Selective inhibitor of Rac1-GEF interaction; antioncogenic 0

(4) Additional Compounds for ARFGAP3 Gene - From: NovoSeek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
QS 11
944328-88-5
Rac1 Inhibitor W56
1095179-01-3
SecinH3
853625-60-2
gtp
Partial agonist, Agonist
genes like me logo Genes that share compounds with ARFGAP3: view

Transcripts for ARFGAP3 Gene

Unigene Clusters for ARFGAP3 Gene

ADP-ribosylation factor GTPase activating protein 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARFGAP3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARFGAP3 Gene

No ASD Table

Relevant External Links for ARFGAP3 Gene

GeneLoc Exon Structure for
ARFGAP3
ECgene alternative splicing isoforms for
ARFGAP3

Expression for ARFGAP3 Gene

mRNA expression in normal human tissues for ARFGAP3 Gene

Protein differential expression in normal tissues from HIPED for ARFGAP3 Gene

This gene is overexpressed in Bone marrow stromal cell (12.3), Heart (9.8), Skin (7.2), and Salivary gland (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARFGAP3 Gene



SOURCE GeneReport for Unigene cluster for ARFGAP3 Gene Hs.685225

mRNA Expression by UniProt/SwissProt for ARFGAP3 Gene

Q9NP61-ARFG3_HUMAN
Tissue specificity: Widely expressed. Highest expression in endocrine glands (pancreas, pituitary gland, salivary gland, and prostate) and testis with a much higher expression in the testis than in the ovary.
genes like me logo Genes that share expression patterns with ARFGAP3: view

Protein tissue co-expression partners for ARFGAP3 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ARFGAP3 Gene

Orthologs for ARFGAP3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARFGAP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARFGAP3 35
  • 86.34 (n)
  • 86.99 (a)
ARFGAP3 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARFGAP3 35
  • 87.73 (n)
  • 88.95 (a)
ARFGAP3 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arfgap3 35
  • 79.52 (n)
  • 80.62 (a)
Arfgap3 16
Arfgap3 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARFGAP3 35
  • 97.76 (n)
  • 97.32 (a)
rat
(Rattus norvegicus)
Mammalia Arfgap3 35
  • 79.13 (n)
  • 80.81 (a)
oppossum
(Monodelphis domestica)
Mammalia ARFGAP3 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 78 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
chicken
(Gallus gallus)
Aves ARFGAP3 35
  • 71.11 (n)
  • 69.89 (a)
ARFGAP3 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARFGAP3 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arfgap3 35
  • 65.43 (n)
  • 65.95 (a)
African clawed frog
(Xenopus laevis)
Amphibia arfgap3-prov 35
zebrafish
(Danio rerio)
Actinopterygii arfgap3 36
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ArfGAP3 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F07F6.4 36
  • 34 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GLO3 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
Species with no ortholog for ARFGAP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARFGAP3 Gene

ENSEMBL:
Gene Tree for ARFGAP3 (if available)
TreeFam:
Gene Tree for ARFGAP3 (if available)

Paralogs for ARFGAP3 Gene

Paralogs for ARFGAP3 Gene

genes like me logo Genes that share paralogs with ARFGAP3: view

Variants for ARFGAP3 Gene

Sequence variations from dbSNP and Humsavar for ARFGAP3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs738534 -- 42,841,633(+) GGGTC(A/G)ACGGT intron-variant
rs738535 -- 42,807,131(+) CTTGC(C/T)GACAG synonymous-codon, reference
rs11705014 -- 42,815,458(+) ATTTA(A/G)AGCTA intron-variant
rs11705375 -- 42,812,282(+) GCTTA(A/G)GATGG intron-variant
rs11705652 -- 42,816,200(+) AACAT(A/G)GTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARFGAP3 Gene

Variant ID Type Subtype PubMed ID
nsv915195 CNV Gain 21882294
nsv915196 CNV Loss 21882294
esv2549553 CNV Insertion 19546169
nsv508738 CNV Insertion 20534489

Variation tolerance for ARFGAP3 Gene

Residual Variation Intolerance Score: 94.76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.89; 67.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARFGAP3 Gene

HapMap Linkage Disequilibrium report
ARFGAP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARFGAP3 Gene

Disorders for ARFGAP3 Gene

Relevant External Links for ARFGAP3

Genetic Association Database (GAD)
ARFGAP3
Human Genome Epidemiology (HuGE) Navigator
ARFGAP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARFGAP3
genes like me logo Genes that share disorders with ARFGAP3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARFGAP3 Gene

Publications for ARFGAP3 Gene

  1. Functional characterization of novel human ARFGAP3. (PMID: 11172815) Liu X. … He F. (FEBS Lett. 2001) 2 23 67
  2. Characterization, chromosomal assignment, and tissue expression of a novel human gene belonging to the ARF GAP family. (PMID: 10704287) Zhang C. … He F. (Genomics 2000) 2 23 67
  3. Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking. (PMID: 19015319) Weimer C. … Wieland F. (J. Cell Biol. 2008) 23 67
  4. Small-molecule synergist of the Wnt/beta-catenin signaling pathway. (PMID: 17460038) Zhang Q. … Ding S. (Proc. Natl. Acad. Sci. U.S.A. 2007) 23 67
  5. Two lipid-packing sensor motifs contribute to the sensitivity of ArfGAP1 to membrane curvature. (PMID: 17253781) Mesmin B. … Antonny B. (Biochemistry 2007) 23 67

Products for ARFGAP3 Gene

Sources for ARFGAP3 Gene

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