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Aliases for ARFGAP3 Gene

Aliases for ARFGAP3 Gene

  • ADP Ribosylation Factor GTPase Activating Protein 3 2 3 5
  • ADP-Ribosylation Factor GTPase Activating Protein 1 2 3
  • ARF GAP 3 3 4
  • ARFGAP1 3 4
  • ADP-Ribosylation Factor GTPase-Activating Protein 3 3

External Ids for ARFGAP3 Gene

Previous HGNC Symbols for ARFGAP3 Gene

  • ARFGAP1

Previous GeneCards Identifiers for ARFGAP3 Gene

  • GC22M039795
  • GC22M041423
  • GC22M041517
  • GC22M043192
  • GC22M026151

Summaries for ARFGAP3 Gene

Entrez Gene Summary for ARFGAP3 Gene

  • The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene. [provided by RefSeq, Nov 2008]

GeneCards Summary for ARFGAP3 Gene

ARFGAP3 (ADP Ribosylation Factor GTPase Activating Protein 3) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Transport to the Golgi and subsequent modification. GO annotations related to this gene include GTPase activator activity and protein transporter activity. An important paralog of this gene is ARFGAP2.

UniProtKB/Swiss-Prot for ARFGAP3 Gene

  • GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.

Tocris Summary for ARFGAP3 Gene

  • Small G proteins (small GTPases) are homologous to Galpha proteins and are often referred to as the Ras proto-oncogene superfamily. Small GTPases regulate a wide variety of processes in the cell, including growth, differentiation, movement and lipid vesicle transport.

Gene Wiki entry for ARFGAP3 Gene

Additional gene information for ARFGAP3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARFGAP3 Gene

Genomics for ARFGAP3 Gene

Regulatory Elements for ARFGAP3 Gene

Enhancers for ARFGAP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H042928 2 FANTOM5 Ensembl ENCODE dbSUPER 40.6 -77.0 -77043 12 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A ZNF143 ZNF207 FOS SP5 ARFGAP3 PACSIN2 NFAM1 OGFRP1 POLDIP3 GC22P042938 GC22M042889
GH22H042891 1.6 FANTOM5 Ensembl ENCODE dbSUPER 33.9 -36.1 -36061 4 PKNOX1 FOXA2 MAX BATF RAD21 YY1 POLR2A EED ETV6 RUNX3 ARFGAP3 PACSIN2 NFAM1 OGFRP1 GC22M042889 GC22P042938
GH22H042957 1.6 Ensembl ENCODE dbSUPER 27.1 -102.5 -102509 6 FOXA2 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 DEK ARFGAP3 PACSIN2 LOC100506679 CYB5R3 ATP5L2 OGFRP1 GC22M042914 PIR35633
GH22H042886 1.7 FANTOM5 Ensembl ENCODE dbSUPER 25.5 -30.8 -30846 4 PKNOX1 TBL1XR1 SIN3A KLF17 BMI1 YBX1 BATF RAD21 YY1 ATF7 ARFGAP3 RRP7BP NFAM1 PACSIN2 POLDIP3 GC22P042889 GC22M042889 PIR60890
GH22H042803 1.2 ENCODE dbSUPER 33.2 +52.7 52682 4 ELF3 FOXA2 ATF1 MLX NFIB THRB ZBTB40 RARA YY1 FOS ARFGAP3 RRP7BP LOC100422416 LOC692246
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARFGAP3 on UCSC Golden Path with GeneCards custom track

Promoters for ARFGAP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000146842 1406 1801 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 SP3

Genomic Location for ARFGAP3 Gene

Chromosome:
22
Start:
42,796,502 bp from pter
End:
42,858,106 bp from pter
Size:
61,605 bases
Orientation:
Minus strand

Genomic View for ARFGAP3 Gene

Genes around ARFGAP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARFGAP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARFGAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARFGAP3 Gene

Proteins for ARFGAP3 Gene

  • Protein details for ARFGAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP61-ARFG3_HUMAN
    Recommended name:
    ADP-ribosylation factor GTPase-activating protein 3
    Protein Accession:
    Q9NP61
    Secondary Accessions:
    • E9PB03
    • Q9BSC6
    • Q9H9J0
    • Q9NT10
    • Q9NUP5
    • Q9Y4V3
    • Q9Y4V4

    Protein attributes for ARFGAP3 Gene

    Size:
    516 amino acids
    Molecular mass:
    56928 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92076.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14236.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARFGAP3 Gene

    Alternative splice isoforms for ARFGAP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARFGAP3 Gene

Post-translational modifications for ARFGAP3 Gene

  • Ubiquitination at Lys392, Lys425, and Lys467
  • Modification sites at PhosphoSitePlus

Other Protein References for ARFGAP3 Gene

Antibody Products

  • Abcam antibodies for ARFGAP3

No data available for DME Specific Peptides for ARFGAP3 Gene

Domains & Families for ARFGAP3 Gene

Gene Families for ARFGAP3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARFGAP3 Gene

Suggested Antigen Peptide Sequences for ARFGAP3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARFGAP3: view

No data available for UniProtKB/Swiss-Prot for ARFGAP3 Gene

Function for ARFGAP3 Gene

Molecular function for ARFGAP3 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2).
UniProtKB/Swiss-Prot Function:
GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.

Phenotypes From GWAS Catalog for ARFGAP3 Gene

Gene Ontology (GO) - Molecular Function for ARFGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA,IEA 11172815
GO:0005515 protein binding IPI 24705354
GO:0008565 protein transporter activity NAS 11172815
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ARFGAP3: view
genes like me logo Genes that share phenotypes with ARFGAP3: view

Animal Model Products

CRISPR Products

miRNA for ARFGAP3 Gene

miRTarBase miRNAs that target ARFGAP3

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ARFGAP3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARFGAP3 Gene

Localization for ARFGAP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARFGAP3 Gene

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARFGAP3 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
nucleus 3
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARFGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA,IDA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA,IEA 19946888
genes like me logo Genes that share ontologies with ARFGAP3: view

Pathways & Interactions for ARFGAP3 Gene

genes like me logo Genes that share pathways with ARFGAP3: view

Pathways by source for ARFGAP3 Gene

Gene Ontology (GO) - Biological Process for ARFGAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport NAS 11172815
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0009306 protein secretion IEP 11172815
genes like me logo Genes that share ontologies with ARFGAP3: view

No data available for SIGNOR curated interactions for ARFGAP3 Gene

Drugs & Compounds for ARFGAP3 Gene

(5) Drugs for ARFGAP3 Gene - From: HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
EHT 1864 Pharma Rac family small GTPases inhibitor, Potent inhibitor of Rac family GTPases 0
NSC 23766 Pharma Selective inhibitor of Rac1-GEF interaction., Selective inhibitor of Rac1-GEF interaction; antioncogenic 0
ZCL278 Pharma Selective Cdc42 inhibitor, Cdc42 inhibitor 0

(3) Additional Compounds for ARFGAP3 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CASIN
425399-05-9
SecinH3
853625-60-2

(5) Tocris Compounds for ARFGAP3 Gene

Compound Action Cas Number
CASIN Cdc42 GTPase inhibitor 425399-05-9
EHT 1864 Potent inhibitor of Rac family GTPases 754240-09-0
NSC 23766 Selective inhibitor of Rac1-GEF interaction; antioncogenic 1177865-17-6
SecinH3 Sec7-specific GEF inhibitor (cytohesins) 853625-60-2
ZCL 278 Cdc42 inhibitor 587841-73-4
genes like me logo Genes that share compounds with ARFGAP3: view

Transcripts for ARFGAP3 Gene

Unigene Clusters for ARFGAP3 Gene

ADP-ribosylation factor GTPase activating protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ARFGAP3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ARFGAP3 Gene

No ASD Table

Relevant External Links for ARFGAP3 Gene

GeneLoc Exon Structure for
ARFGAP3
ECgene alternative splicing isoforms for
ARFGAP3

Expression for ARFGAP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARFGAP3 Gene

Protein differential expression in normal tissues from HIPED for ARFGAP3 Gene

This gene is overexpressed in Bone marrow stromal cell (12.3), Heart (9.8), Skin (7.2), and Salivary gland (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARFGAP3 Gene



Protein tissue co-expression partners for ARFGAP3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARFGAP3 Gene:

ARFGAP3

SOURCE GeneReport for Unigene cluster for ARFGAP3 Gene:

Hs.685225

mRNA Expression by UniProt/SwissProt for ARFGAP3 Gene:

Q9NP61-ARFG3_HUMAN
Tissue specificity: Widely expressed. Highest expression in endocrine glands (pancreas, pituitary gland, salivary gland, and prostate) and testis with a much higher expression in the testis than in the ovary.

Evidence on tissue expression from TISSUES for ARFGAP3 Gene

  • Liver(4.3)
  • Lung(4.3)
  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with ARFGAP3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARFGAP3 Gene

Orthologs for ARFGAP3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARFGAP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARFGAP3 33
  • 97.76 (n)
dog
(Canis familiaris)
Mammalia ARFGAP3 33 34
  • 87.73 (n)
cow
(Bos Taurus)
Mammalia ARFGAP3 33 34
  • 86.34 (n)
mouse
(Mus musculus)
Mammalia Arfgap3 33 16 34
  • 79.52 (n)
rat
(Rattus norvegicus)
Mammalia Arfgap3 33
  • 79.13 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 78 (a)
OneToMany
-- 34
  • 66 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ARFGAP3 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARFGAP3 33 34
  • 71.11 (n)
lizard
(Anolis carolinensis)
Reptilia ARFGAP3 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arfgap3 33
  • 65.43 (n)
African clawed frog
(Xenopus laevis)
Amphibia arfgap3-prov 33
zebrafish
(Danio rerio)
Actinopterygii arfgap3 34
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ArfGAP3 34
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F07F6.4 34
  • 34 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GLO3 34
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
ManyToMany
-- 34
  • 30 (a)
ManyToMany
Species where no ortholog for ARFGAP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARFGAP3 Gene

ENSEMBL:
Gene Tree for ARFGAP3 (if available)
TreeFam:
Gene Tree for ARFGAP3 (if available)

Paralogs for ARFGAP3 Gene

Paralogs for ARFGAP3 Gene

genes like me logo Genes that share paralogs with ARFGAP3: view

Variants for ARFGAP3 Gene

Sequence variations from dbSNP and Humsavar for ARFGAP3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_036177 A breast cancer sample
rs1000009961 -- 42,840,600(+) TTATT(-/A)TTTTT intron-variant
rs1000099782 -- 42,855,015(+) GACTA(C/T)TATAT intron-variant
rs1000100336 -- 42,801,661(+) GTGGG(C/T)AGGTG intron-variant
rs1000137448 -- 42,809,004(+) GATTT(C/T)AGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARFGAP3 Gene

Variant ID Type Subtype PubMed ID
esv2549553 CNV insertion 19546169
nsv508738 CNV insertion 20534489
nsv589084 CNV loss 21841781

Variation tolerance for ARFGAP3 Gene

Residual Variation Intolerance Score: 94.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.89; 67.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARFGAP3 Gene

Human Gene Mutation Database (HGMD)
ARFGAP3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARFGAP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARFGAP3 Gene

Disorders for ARFGAP3 Gene

Relevant External Links for ARFGAP3

Genetic Association Database (GAD)
ARFGAP3
Human Genome Epidemiology (HuGE) Navigator
ARFGAP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARFGAP3

No disorders were found for ARFGAP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARFGAP3 Gene

Publications for ARFGAP3 Gene

  1. Functional characterization of novel human ARFGAP3. (PMID: 11172815) Liu X … He F (FEBS letters 2001) 2 3 4 22 60
  2. Characterization, chromosomal assignment, and tissue expression of a novel human gene belonging to the ARF GAP family. (PMID: 10704287) Zhang C … He F (Genomics 2000) 2 3 4 22 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking. (PMID: 19015319) Weimer C … Wieland F (The Journal of cell biology 2008) 3 22 60
  5. Two human ARFGAPs associated with COP-I-coated vesicles. (PMID: 17760859) Frigerio G … Duden R (Traffic (Copenhagen, Denmark) 2007) 3 4 60

Products for ARFGAP3 Gene

Sources for ARFGAP3 Gene

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