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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARFGAP2 Gene

protein-coding   GIFtS: 54
GCID: GC11M047185

ADP-Ribosylation Factor GTPase Activating Protein 2

(Previous names: zinc finger protein 289, ID1 regulated)
(Previous symbol: ZNF289)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ADP-Ribosylation Factor GTPase Activating Protein 21 2     NBLA105352
ZNF2891 2 3 5     ZFP2892
Zinc Finger Protein 289, ID1 Regulated1 2     ADP-Ribosylation Factor GTPase-Activating Protein 22
GTPase-Activating Protein ZNF2892 3     ARF GAP 23
IRZ2     Zinc Finger Protein 2893

External Ids:    HGNC: 135041   Entrez Gene: 843642   Ensembl: ENSG000001491827   OMIM: 6069085   UniProtKB: Q8N6H73   

Export aliases for ARFGAP2 gene to outside databases

Previous GC identifers: GC11M047143 GC11M046884


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ARFGAP2 Gene: 
ARFGAP2 (ADP-ribosylation factor GTPase activating protein 2) is a protein-coding gene. Diseases associated with ARFGAP2 include sudden infant death syndrome, and cholera. GO annotations related to this gene include ARF GTPase activator activity and zinc ion binding. An important paralog of this gene is ARFGAP3.

UniProtKB/Swiss-Prot: ARFG2_HUMAN, Q8N6H7
Function: GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated
protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead
to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARFGAP2 gene promoter:
         GR   AhR   NF-1/L   NF-1   RP58   GR-beta   STAT1beta   Arnt   AREB6   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARFGAP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARFGAP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARFGAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2-p11.12   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2-p11.12

ARFGAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARFGAP2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M047185:  view genomic region     (about GC identifiers)

Start:
47,185,848 bp from pter      End:
47,198,676 bp from pter
Size:
12,829 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARFG2_HUMAN, Q8N6H7 (See protein sequence)
Recommended Name: ADP-ribosylation factor GTPase-activating protein 2  
Size: 521 amino acids; 56720 Da
Subunit: Interacts with the coatomer complex. Interacts with the C-terminal appendage domain of COPG1
Subcellular location: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate
compartment
Miscellaneous: Vero cells overexpressing truncated ARFGAP2 show accumulation of cholera toxin A subunit in the
Golgi complex rather than the endoplasmic reticulum
1 PDB 3D structure from and Proteopedia for ARFGAP2:
2P57 (3D)    
Secondary accessions: D3DQQ9 Q3LIF2 Q8N3I1 Q96SX7

Explore the universe of human proteins at neXtProt for ARFGAP2: NX_Q8N6H7

Explore proteomics data for ARFGAP2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N6H7

  • ARFGAP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARFGAP2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001229761.1  NP_115765.2  

    ENSEMBL proteins: 
     ENSP00000434442   ENSP00000433210   ENSP00000434022   ENSP00000437305   ENSP00000434433  
     ENSP00000437194   ENSP00000432978   ENSP00000434487   ENSP00000431939   ENSP00000434809  
     ENSP00000431684   ENSP00000437070   ENSP00000431238   ENSP00000435488   ENSP00000431847  
     ENSP00000433108   ENSP00000400226   ENSP00000389264   ENSP00000327309  

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    Cloud-Clone Corp. Proteins for ARFGAP2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005886plasma membrane ----

    ARFGAP2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ArfGAP: ADP-ribosylation factor GTPase activating proteins

    1 InterPro protein domain:
     IPR001164 ArfGAP

    Graphical View of Domain Structure for InterPro Entry Q8N6H7

    ProtoNet protein and cluster: Q8N6H7

    1 Blocks protein domain: IPB001164 HIV Rev interacting protein signature

    UniProtKB/Swiss-Prot: ARFG2_HUMAN, Q8N6H7
    Similarity: Contains 1 Arf-GAP domain


    ARFGAP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARFG2_HUMAN, Q8N6H7
    Function: GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated
    protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead
    to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008060ARF GTPase activator activity IEA--
    GO:0008270zinc ion binding IEA--
         
    ARFGAP2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ARFGAP2:
     Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ARFGAP2 
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    SwitchGear 3'UTR luciferase reporter plasmidARFGAP2 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARFGAP2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Endocytosis
    Endocytosis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for ARFGAP2):
        Endocytosis


    ARFGAP2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARFGAP2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for ARFGAP2 (ENSP000003273094) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD1ENSP000003057694STRING: ENSP00000305769
    UBCENSP000003448184STRING: ENSP00000344818
    MAD2L1ENSP000002965094STRING: ENSP00000296509
    COPB1ENSP000002499234STRING: ENSP00000249923
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--
    GO:0016192vesicle-mediated transport IEA--
    GO:0032312regulation of ARF GTPase activity IEA--

    ARFGAP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARFGAP2 (ARFG2)

    1 HMDB Compound for ARFGAP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about ARFGAP2 / ARFG2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARFGAP2 gene (2 alternative transcripts): 
    NM_001242832.1  NM_032389.4  

    Unigene Cluster for ARFGAP2:

    ADP-ribosylation factor GTPase activating protein 2
    Hs.436204  [show with all ESTs]
    Unigene Representative Sequence: NM_032389
    18/30 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000524782(uc010rha.2 uc001ndt.3 uc010rhb.2 uc001ndu.3 uc010rhc.2)
    ENST00000395449 ENST00000533243 ENST00000527776 ENST00000526342 ENST00000527927
    ENST00000532478 ENST00000525635 ENST00000532438 ENST00000529455 ENST00000525398
    ENST00000526948 ENST00000531750 ENST00000525314 ENST00000527097 ENST00000528444
    ENST00000524727(uc010rhd.2) ENST00000529599
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    hsa-miR-15a hsa-miR-132 hsa-miR-424 hsa-miR-129-3p hsa-miR-514b-3p hsa-miR-212 hsa-miR-195 hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidARFGAP2 3' UTR sequence
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    Additional mRNA sequence: 

    AB073358.1 AK027482.1 AK098324.1 AK129511.1 AK300347.1 AK301785.1 AK304541.1 AK315992.1 
    AL834337.1 BC030148.2 BC036823.1 

    24/39 DOTS entries (see all 39):

    DT.100879099  DT.97778051  DT.427417  DT.85101178  DT.95212488  DT.120707572  DT.100879103  DT.95212494 
    DT.100879078  DT.95148560  DT.97860165  DT.120707642  DT.97860166  DT.91774067  DT.100031497  DT.120707451 
    DT.99972933  DT.40221227  DT.87014096  DT.95212467  DT.95212489  DT.92029432  DT.95212472  DT.100662537 

    24/713 AceView cDNA sequences (see all 713):

    AW152123 AI073515 CN479159 CD672017 BM704415 BX364814 F26225 NM_032389 
    BQ228732 BQ233614 AW732250 CA313336 BM694539 BM480257 AV645750 BM828157 
    AA350150 BQ614613 CA309915 AL834337 AW410340 BM044239 BC030148 CB153664 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ARFGAP2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                    -           -     -     -     -     -                       -                                       
    SP2:                    -           -     -                                                                                 
    SP3:                    -           -                                                                                       
    SP4:                    -                                                                                                   
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for ARFGAP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARFGAP2 expression in normal human tissues (normalized intensities)      ARFGAP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGGTCTTG
    ARFGAP2 Expression
    About this image


    ARFGAP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/29 selected tissues (see all 29) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   

    See ARFGAP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARFGAP2

    SOURCE GeneReport for Unigene cluster: Hs.436204
        SABiosciences Custom PCR Arrays for ARFGAP2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARFGAP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARFGAP2 gene from 10/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arfgap21 , 5 ADP-ribosylation factor GTPase activating protein 21, 5 88.91(n)1
    92.69(a)1
      2 (50.62 cM)5
    770381  NM_001166024.11  NP_001159496.11 
     912649745 
    chicken
    (Gallus gallus)
    Aves ARFGAP21 ADP-ribosylation factor GTPase activating protein 2 77.24(n)
    81.24(a)
      423187  NM_001033871.2  NP_001029043.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 8)
    Uncharacterized protein
    (see all 8)
    73(a)
    64(a)
    (see all 8)
    1 ↔ many
    1 ↔ many
    (see all 8)
    1(43580704-43599325)
    5(72864374-72865195)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.60002 Transcribed sequence with weak similarity to protein more 77.15(n)    BX708862.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa11e072 wufa11e07 77.94(n)   334995  CA472676.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG68381 CG6838 50.9(n)
    42.91(a)
      40487  NM_001104193.1  NP_001097663.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F07F6.41 Protein F07F6.4 47.7(n)
    40.17(a)
      173927  NM_062628.3  NP_495029.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GLO3(YER122C)4 ADP-ribosylation factor GTPase activating protein (ARF more   --   5(404352-402871) 856859  NP_011048.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RPA1 ADP-ribosylation factor GTPase-activating protein AGD1 more 49.34(n)
    45.79(a)
      818088  NM_129074.2  NP_565801.1 
    barley
    (Hordeum vulgare)
    Liliopsida Hv.51062 Transcribed sequence with weak similarity to protein more 73.79(n)    BI950554.1 


    ENSEMBL Gene Tree for ARFGAP2 (if available)
    TreeFam Gene Tree for ARFGAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARFGAP2 gene
    ARFGAP32  
    8 SIMAP similar genes for ARFGAP2 using alignment to 19 protein entries:     ARFG2_HUMAN (see all proteins):
    ARFGAP3    ARFGAP1    AGAP8    ASAP1    AGAP1    ADAP2
    GIT1    SMAP1

    ARFGAP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/430 SNPs in ARFGAP2 are shown (see all 430)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs47529681,2
    C,F,A--46884443(+) CTCCCG/AAAGTG 2 -- int12Minor allele frequency- A:0.50NA 4
    rs47529691,2
    C,F,A,H--46884496(+) TTCTTA/GAACTC 2 -- int124Minor allele frequency- G:0.34NA NS EA CSA WA 2491
    rs1999366321,2
    --46884608(+) GCCAGC/TTCTTT 2 -- int10--------
    rs2002975761,2
    C--46884621(+) TCTGCG/ATGCCA 2 -- int11Minor allele frequency- A:0.00EU 1059
    rs1500539181,2
    C,F--46884653(+) GCACCG/AGACCT 2 -- int11Minor allele frequency- A:0.00NA 4550
    rs110391141,2
    C,F,H--46884666(+) CGGCAG/ACACAG 2 -- int118Minor allele frequency- A:0.16NS EA NA EU 7592
    rs1389079901,2
    F--46884724(+) AGGCCC/TTGGAG 2 -- int11Minor allele frequency- T:0.00NA 4446
    rs1480269971,2
    C--46884755(+) ACCGAC/TGCCCT 2 -- int11Minor allele frequency- T:0.00NA 4400
    rs2011726471,2
    --46884777(+) TGGGAC/GCCCAG 2 -- int10--------
    rs2018008741,2
    C--46884800(+) GGGGCC/TGCACT 2 -- int11Minor allele frequency- T:0.00EU 439

    HapMap Linkage Disequilibrium report for ARFGAP2 (47185848 - 47198676 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ARFGAP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv897323CNV Loss21882294
    nsv897324CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606908    OMIM disorders: --

    5 diseases for ARFGAP2:    About MalaCards
    sudden infant death syndrome    cholera    neuroblastoma    gastric cancer
    breast cancer


    ARFGAP2 for disorders           About GeneDecksing


    Export disorders for ARFGAP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARFGAP2 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with ARFGAP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gamma-COP appendage domain -- structure and function. (PubMed id 14690497)1, 2, 3 Watson P.J.... Owen D.J. (2004)
    2. Two human ARFGAPs associated with COP-I-coated vesicles. (PubMed id 17760859)1, 2 Frigerio G.... Duden R. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. (PubMed id 12880961)1, 2 Ohira M.... Nakagawara A. (2003)
    6. Molecular cloning and characterization of a zinc finger protein involved in Id-1-stimulated mammary epithelial cell growth. (PubMed id 11278321)1, 3 Singh J....Desprez P.Y. (2001)
    7. VCP phosphorylation-dependent interaction partners pre vent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (2013)
    8. Distinct role of subcomplexes of the COPI coat in the regulation of ArfGAP2 activity. (PubMed id 22375848)1 Pevzner I....Cassel D. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84364 HGNC: 13504 AceView: PACSIN3andZNF289 Ensembl:ENSG00000149182 euGenes: HUgn84364
    ECgene: ARFGAP2 Kegg: 84364 H-InvDB: ARFGAP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARFGAP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARFGAP2 gene:
    Search GeneIP for patents involving ARFGAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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