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Aliases for ARFGAP2 Gene

Aliases for ARFGAP2 Gene

  • ADP Ribosylation Factor GTPase Activating Protein 2 2 3 5
  • Zinc Finger Protein 289, ID1 Regulated 2 3
  • GTPase-Activating Protein ZNF289 3 4
  • ZNF289 3 4
  • ADP-Ribosylation Factor GTPase Activating Protein 2 3
  • Zinc Finger Protein 289 4
  • NBLA10535 3
  • ARF GAP 2 4
  • ZFP289 3
  • IRZ 3

External Ids for ARFGAP2 Gene

Previous HGNC Symbols for ARFGAP2 Gene

  • ZNF289

Previous GeneCards Identifiers for ARFGAP2 Gene

  • GC11M047143
  • GC11M046884
  • GC11M047185
  • GC11M047280
  • GC11M047937

Summaries for ARFGAP2 Gene

GeneCards Summary for ARFGAP2 Gene

ARFGAP2 (ADP Ribosylation Factor GTPase Activating Protein 2) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Endocytosis. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARFGAP3.

UniProtKB/Swiss-Prot for ARFGAP2 Gene

  • GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARFGAP2 Gene

Genomics for ARFGAP2 Gene

Regulatory Elements for ARFGAP2 Gene

Promoters for ARFGAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARFGAP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARFGAP2 Gene

Chromosome:
11
Start:
47,164,298 bp from pter
End:
47,177,503 bp from pter
Size:
13,206 bases
Orientation:
Minus strand

Genomic View for ARFGAP2 Gene

Genes around ARFGAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARFGAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARFGAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARFGAP2 Gene

Proteins for ARFGAP2 Gene

  • Protein details for ARFGAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6H7-ARFG2_HUMAN
    Recommended name:
    ADP-ribosylation factor GTPase-activating protein 2
    Protein Accession:
    Q8N6H7
    Secondary Accessions:
    • B4DX29
    • B7Z9M7
    • D3DQQ9
    • Q3LIF2
    • Q8N3I1
    • Q96SX7

    Protein attributes for ARFGAP2 Gene

    Size:
    521 amino acids
    Molecular mass:
    56720 Da
    Quaternary structure:
    • Interacts with the coatomer complex. Interacts with the C-terminal appendage domain of COPG1.
    Miscellaneous:
    • Vero cells overexpressing truncated ARFGAP2 show accumulation of cholera toxin A subunit in the Golgi complex rather than the endoplasmic reticulum.

    Three dimensional structures from OCA and Proteopedia for ARFGAP2 Gene

    Alternative splice isoforms for ARFGAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARFGAP2 Gene

Proteomics data for ARFGAP2 Gene at MOPED

Post-translational modifications for ARFGAP2 Gene

  • Ubiquitination at Lys 429
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARFGAP2 Gene

Domains & Families for ARFGAP2 Gene

Gene Families for ARFGAP2 Gene

Protein Domains for ARFGAP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N6H7

UniProtKB/Swiss-Prot:

ARFG2_HUMAN :
  • Contains 1 Arf-GAP domain.
Domain:
  • Contains 1 Arf-GAP domain.
genes like me logo Genes that share domains with ARFGAP2: view

Function for ARFGAP2 Gene

Molecular function for ARFGAP2 Gene

UniProtKB/Swiss-Prot Function:
GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.
genes like me logo Genes that share phenotypes with ARFGAP2: view

Animal Model Products

CRISPR Products

miRNA for ARFGAP2 Gene

miRTarBase miRNAs that target ARFGAP2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARFGAP2 Gene

Localization for ARFGAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARFGAP2 Gene

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARFGAP2 Gene COMPARTMENTS Subcellular localization image for ARFGAP2 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
plasma membrane 5
nucleus 4

No data available for Gene Ontology (GO) - Cellular Components for ARFGAP2 Gene

Pathways & Interactions for ARFGAP2 Gene

genes like me logo Genes that share pathways with ARFGAP2: view

Pathways by source for ARFGAP2 Gene

Interacting Proteins for ARFGAP2 Gene

Gene Ontology (GO) - Biological Process for ARFGAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ARFGAP2: view

No data available for SIGNOR curated interactions for ARFGAP2 Gene

Drugs & Compounds for ARFGAP2 Gene

(1) Drugs for ARFGAP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARFGAP2: view

Transcripts for ARFGAP2 Gene

Unigene Clusters for ARFGAP2 Gene

ADP-ribosylation factor GTPase activating protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARFGAP2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - - - - -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6:
SP7:

Relevant External Links for ARFGAP2 Gene

GeneLoc Exon Structure for
ARFGAP2
ECgene alternative splicing isoforms for
ARFGAP2

Expression for ARFGAP2 Gene

mRNA expression in normal human tissues for ARFGAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARFGAP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARFGAP2 Gene



SOURCE GeneReport for Unigene cluster for ARFGAP2 Gene Hs.436204

genes like me logo Genes that share expression patterns with ARFGAP2: view

Protein tissue co-expression partners for ARFGAP2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARFGAP2 Gene

Orthologs for ARFGAP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARFGAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARFGAP2 35
  • 99.87 (n)
  • 99.81 (a)
ARFGAP2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARFGAP2 36
  • 77 (a)
OneToOne
ARFGAP2 35
  • 90.45 (n)
  • 94.42 (a)
dog
(Canis familiaris)
Mammalia ARFGAP2 35
  • 91.41 (n)
  • 93.65 (a)
ARFGAP2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arfgap2 16
Arfgap2 36
  • 90 (a)
OneToOne
Arfgap2 35
  • 88.97 (n)
  • 92.69 (a)
oppossum
(Monodelphis domestica)
Mammalia ARFGAP2 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARFGAP2 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arfgap2 35
  • 89.17 (n)
  • 93.27 (a)
chicken
(Gallus gallus)
Aves ARFGAP2 36
  • 80 (a)
OneToOne
ARFGAP2 35
  • 77.24 (n)
  • 81.43 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 63 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia arfgap2 35
  • 70.72 (n)
  • 74.9 (a)
Str.6000 35
zebrafish
(Danio rerio)
Actinopterygii arfgap2 35
  • 70.47 (n)
  • 72.92 (a)
wufa11e07 35
arfgap2 36
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005609 35
  • 50.1 (n)
  • 45.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta ArfGAP3 36
  • 37 (a)
OneToMany
ArfGAP3 35
  • 50.43 (n)
  • 43.09 (a)
worm
(Caenorhabditis elegans)
Secernentea F07F6.4 36
  • 34 (a)
OneToMany
F07F6.4 35
  • 48.01 (n)
  • 41.09 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GLO3 36
  • 22 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons RPA 35
  • 51.34 (n)
  • 49.84 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.5106 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
Species with no ortholog for ARFGAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARFGAP2 Gene

ENSEMBL:
Gene Tree for ARFGAP2 (if available)
TreeFam:
Gene Tree for ARFGAP2 (if available)

Paralogs for ARFGAP2 Gene

Paralogs for ARFGAP2 Gene

genes like me logo Genes that share paralogs with ARFGAP2: view

Variants for ARFGAP2 Gene

Sequence variations from dbSNP and Humsavar for ARFGAP2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs3740691 - 47,166,860(-) GGAGA(A/G)CCGGA reference, missense
rs11542793 - 47,175,067(-) CGTTC(C/G)TAATC intron-variant, reference, missense
rs34662994 - 47,168,177(-) CTCTC(A/G/T)CTCGC reference, missense
rs35950498 - 47,166,876(-) CAAAC(C/G/T)GGAGG reference, missense
rs958128 -- 47,168,304(-) TGCGG(G/T)GATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARFGAP2 Gene

Variant ID Type Subtype PubMed ID
nsv897323 CNV Loss 21882294
nsv897324 CNV Loss 21882294

Variation tolerance for ARFGAP2 Gene

Residual Variation Intolerance Score: 59.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.35; 92.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARFGAP2 Gene

HapMap Linkage Disequilibrium report
ARFGAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARFGAP2 Gene

Disorders for ARFGAP2 Gene

Relevant External Links for ARFGAP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARFGAP2

No disorders were found for ARFGAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARFGAP2 Gene

Publications for ARFGAP2 Gene

  1. Gamma-COP appendage domain -- structure and function. (PMID: 14690497) Watson P.J. … Owen D.J. (Traffic 2004) 2 3 4 67
  2. Molecular cloning and characterization of a zinc finger protein involved in Id-1-stimulated mammary epithelial cell growth. (PMID: 11278321) Singh J. … Desprez P.Y. (J. Biol. Chem. 2001) 2 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation. (PMID: 25496667) Landi A. … Verhasselt B. (Retrovirology 2014) 3
  5. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PMID: 23383273) Yu C.C. … Chow L.P. (PLoS ONE 2013) 3

Products for ARFGAP2 Gene

Sources for ARFGAP2 Gene

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