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Aliases for ARFGAP2 Gene

Aliases for ARFGAP2 Gene

  • ADP-Ribosylation Factor GTPase Activating Protein 2 2 3
  • ZNF289 3 4 6
  • Zinc Finger Protein 289, ID1 Regulated 2 3
  • GTPase-Activating Protein ZNF289 3 4
  • ADP-Ribosylation Factor GTPase-Activating Protein 2 3
  • Zinc Finger Protein 289 4
  • NBLA10535 3
  • ARF GAP 2 4
  • ZFP289 3
  • IRZ 3

External Ids for ARFGAP2 Gene

Previous Symbols for ARFGAP2 Gene

  • ZNF289

Summaries for ARFGAP2 Gene

GeneCards Summary for ARFGAP2 Gene

ARFGAP2 (ADP-Ribosylation Factor GTPase Activating Protein 2) is a Protein Coding gene. Among its related pathways are Endocytosis. An important paralog of this gene is ARFGAP3.

UniProtKB/Swiss-Prot for ARFGAP2 Gene

  • GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARFGAP2 Gene

Genomics for ARFGAP2 Gene

Genomic Location for ARFGAP2 Gene

47,164,298 bp from pter
47,177,503 bp from pter
13,206 bases
Minus strand

Genomic View for ARFGAP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARFGAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARFGAP2 Gene

Regulatory Elements for ARFGAP2 Gene

Proteins for ARFGAP2 Gene

  • Protein details for ARFGAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP-ribosylation factor GTPase-activating protein 2
    Protein Accession:
    Secondary Accessions:
    • B4DX29
    • B7Z9M7
    • D3DQQ9
    • Q3LIF2
    • Q8N3I1
    • Q96SX7

    Protein attributes for ARFGAP2 Gene

    521 amino acids
    Molecular mass:
    56720 Da
    Quaternary structure:
    • Interacts with the coatomer complex. Interacts with the C-terminal appendage domain of COPG1.
    • Vero cells overexpressing truncated ARFGAP2 show accumulation of cholera toxin A subunit in the Golgi complex rather than the endoplasmic reticulum

    Three dimensional structures from OCA and Proteopedia for ARFGAP2 Gene

    Alternative splice isoforms for ARFGAP2 Gene


neXtProt entry for ARFGAP2 Gene

Proteomics data for ARFGAP2 Gene at MOPED

Post-translational modifications for ARFGAP2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys429

No data available for DME Specific Peptides for ARFGAP2 Gene

Domains for ARFGAP2 Gene

Gene Families for ARFGAP2 Gene

  • ArfGAP :ADP-ribosylation factor GTPase activating proteins

Protein Domains for ARFGAP2 Gene


  • Contains 1 Arf-GAP domain.:
    • Q8N6H7
genes like me logo Genes that share domains with ARFGAP2: view

Function for ARFGAP2 Gene

Molecular function for ARFGAP2 Gene

UniProtKB/Swiss-Prot Function: GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.

Gene Ontology (GO) - Molecular Function for ARFGAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ARFGAP2: view

Phenotypes for ARFGAP2 Gene

GenomeRNAi human phenotypes for ARFGAP2:
genes like me logo Genes that share phenotypes with ARFGAP2: view

miRNA for ARFGAP2 Gene

miRTarBase miRNAs that target ARFGAP2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARFGAP2 Gene

Localization for ARFGAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARFGAP2 Gene

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment.

Subcellular locations from

Jensen Localization Image for ARFGAP2 Gene COMPARTMENTS Subcellular localization image for ARFGAP2 gene
Compartment Confidence
golgi apparatus 5
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for ARFGAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with ARFGAP2: view

Pathways for ARFGAP2 Gene

SuperPathways for ARFGAP2 Gene

Superpath Contained pathways
1 Endocytosis
genes like me logo Genes that share pathways with ARFGAP2: view

Pathways by source for ARFGAP2 Gene

1 KEGG pathway for ARFGAP2 Gene

Interacting Proteins for ARFGAP2 Gene

Gene Ontology (GO) - Biological Process for ARFGAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ARFGAP2: view

Compounds for ARFGAP2 Gene

(1) HMDB Compounds for ARFGAP2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with ARFGAP2: view

Transcripts for ARFGAP2 Gene

Unigene Clusters for ARFGAP2 Gene

ADP-ribosylation factor GTPase activating protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARFGAP2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - - - - -
SP2: - - -
SP3: - -
SP4: -

Relevant External Links for ARFGAP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARFGAP2 Gene

mRNA expression in normal human tissues for ARFGAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARFGAP2 Gene

SOURCE GeneReport for Unigene cluster for ARFGAP2 Gene Hs.436204

genes like me logo Genes that share expressions with ARFGAP2: view

Orthologs for ARFGAP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARFGAP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARFGAP2 36
  • 99.87 (n)
  • 99.81 (a)
  • 100 (a)
(Bos Taurus)
Mammalia ARFGAP2 36
  • 90.45 (n)
  • 94.42 (a)
  • 77 (a)
(Canis familiaris)
Mammalia ARFGAP2 36
  • 91.41 (n)
  • 93.65 (a)
  • 94 (a)
(Mus musculus)
Mammalia Arfgap2 36
  • 88.97 (n)
  • 92.69 (a)
Arfgap2 16
Arfgap2 37
  • 90 (a)
(Monodelphis domestica)
Mammalia ARFGAP2 37
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia ARFGAP2 37
  • 84 (a)
(Rattus norvegicus)
Mammalia Arfgap2 36
  • 89.17 (n)
  • 93.27 (a)
(Gallus gallus)
Aves ARFGAP2 36
  • 77.24 (n)
  • 81.43 (a)
  • 80 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 63 (a)
-- 37
  • 73 (a)
-- 37
  • 63 (a)
-- 37
  • 63 (a)
-- 37
  • 63 (a)
-- 37
  • 66 (a)
-- 37
  • 63 (a)
-- 37
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arfgap2 36
  • 70.72 (n)
  • 74.9 (a)
Str.6000 36
(Danio rerio)
Actinopterygii arfgap2 36
  • 70.47 (n)
  • 72.92 (a)
arfgap2 37
  • 70 (a)
wufa11e07 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005609 36
  • 50.1 (n)
  • 45.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta ArfGAP3 36
  • 50.43 (n)
  • 43.09 (a)
ArfGAP3 37
  • 37 (a)
(Caenorhabditis elegans)
Secernentea F07F6.4 36
  • 48.01 (n)
  • 41.09 (a)
F07F6.4 37
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GLO3 37
  • 22 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RPA 36
  • 51.34 (n)
  • 49.84 (a)
(Hordeum vulgare)
Liliopsida Hv.5106 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 40 (a)
-- 37
  • 31 (a)
Species with no ortholog for ARFGAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARFGAP2 Gene

Gene Tree for ARFGAP2 (if available)
Gene Tree for ARFGAP2 (if available)

Paralogs for ARFGAP2 Gene

Paralogs for ARFGAP2 Gene

genes like me logo Genes that share paralogs with ARFGAP2: view

Variants for ARFGAP2 Gene

Sequence variations from dbSNP and Humsavar for ARFGAP2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs958128 -- 47,168,304(-) TGCGG(G/T)GATGC intron-variant
rs2279439 -- 47,175,431(-) GTAGC(A/G)TGTAT intron-variant
rs2867972 -- 47,169,687(+) ACCCT(A/G)TCTCT intron-variant
rs3740690 -- 47,167,041(-) TCCTC(A/G)CCAGG intron-variant
rs3740691 - 47,166,860(-) GGAGA(A/G)CCGGA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for ARFGAP2 Gene

Variant ID Type Subtype PubMed ID
nsv897323 CNV Loss 21882294
nsv897324 CNV Loss 21882294

Relevant External Links for ARFGAP2 Gene

HapMap Linkage Disequilibrium report

Disorders for ARFGAP2 Gene

No disorders were found for ARFGAP2 Gene.

No data available for UniProtKB/Swiss-Prot for ARFGAP2 Gene

Publications for ARFGAP2 Gene

  1. Gamma-COP appendage domain -- structure and function. (PMID: 14690497) Watson P.J. … Owen D.J. (Traffic 2004) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Molecular cloning and characterization of a zinc finger protein involved in Id-1-stimulated mammary epithelial cell growth. (PMID: 11278321) Singh J. … Desprez P.Y. (J. Biol. Chem. 2001) 2 3
  5. Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. (PMID: 12880961) Ohira M. … Nakagawara A. (Cancer Lett. 2003) 3 4

Products for ARFGAP2 Gene

Sources for ARFGAP2 Gene

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