Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ARFGAP2 Gene

protein-coding   GIFtS: 54
GCID: GC11M047185

ADP-Ribosylation Factor GTPase Activating Protein 2

(Previous names: zinc finger protein 289, ID1 regulated)
(Previous symbol: ZNF289)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
ADP-Ribosylation Factor GTPase Activating Protein 21 2     NBLA105352
ZNF2891 2 3 5     ZFP2892
Zinc Finger Protein 289, ID1 Regulated1 2     ADP-Ribosylation Factor GTPase-Activating Protein 22
GTPase-Activating Protein ZNF2892 3     ARF GAP 23
IRZ2     Zinc Finger Protein 2893

External Ids:    HGNC: 135041   Entrez Gene: 843642   Ensembl: ENSG000001491827   OMIM: 6069085   UniProtKB: Q8N6H73   

Export aliases for ARFGAP2 gene to outside databases

Previous GC identifers: GC11M047143 GC11M046884


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for ARFGAP2 Gene:
ARFGAP2 (ADP-ribosylation factor GTPase activating protein 2) is a protein-coding gene. GO annotations related to this gene include ARF GTPase activator activity. An important paralog of this gene is ARFGAP3.

UniProtKB/Swiss-Prot: ARFG2_HUMAN, Q8N6H7
Function: GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated
protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead
to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARFGAP2 gene promoter:
         GR   AhR   NF-1/L   NF-1   RP58   GR-beta   STAT1beta   Arnt   AREB6   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARFGAP2 promoter sequence
   Search Chromatin IP Primers for ARFGAP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARFGAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2-p11.12   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2-p11.12

ARFGAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARFGAP2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M047185:  view genomic region     (about GC identifiers)

Start:
47,185,848 bp from pter      End:
47,198,676 bp from pter
Size:
12,829 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ARFG2_HUMAN, Q8N6H7 (See protein sequence)
Recommended Name: ADP-ribosylation factor GTPase-activating protein 2  
Size: 521 amino acids; 56720 Da
Subunit: Interacts with the coatomer complex. Interacts with the C-terminal appendage domain of COPG1
Miscellaneous: Vero cells overexpressing truncated ARFGAP2 show accumulation of cholera toxin A subunit in the
Golgi complex rather than the endoplasmic reticulum
1 PDB 3D structure from and Proteopedia for ARFGAP2:
2P57 (3D)    
Secondary accessions: D3DQQ9 Q3LIF2 Q8N3I1 Q96SX7

Explore the universe of human proteins at neXtProt for ARFGAP2: NX_Q8N6H7

Explore proteomics data for ARFGAP2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys429
  • Modification sites at PhosphoSitePlus

  • See ARFGAP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001229761.1  NP_115765.2  

    ENSEMBL proteins: 
     ENSP00000434442   ENSP00000433210   ENSP00000434022   ENSP00000437305   ENSP00000434433  
     ENSP00000437194   ENSP00000432978   ENSP00000434487   ENSP00000431939   ENSP00000434809  
     ENSP00000431684   ENSP00000437070   ENSP00000431238   ENSP00000435488   ENSP00000431847  
     ENSP00000433108   ENSP00000400226   ENSP00000389264   ENSP00000327309  

    ARFGAP2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ARFGAP2
    GenScript Custom Purified and Recombinant Proteins Services for ARFGAP2
    Novus Biologicals ARFGAP2 Protein
    Novus Biologicals ARFGAP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ARFGAP2

     
    Search eBioscience for Proteins for ARFGAP2 

    ARFGAP2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ARFGAP2
    OriGene Custom Antibody Services for ARFGAP2
    Novus Biologicals ARFGAP2 Antibodies
    Search for Antibodies for ARFGAP2 at Abcam
    Cloud-Clone Corp. Antibodies for ARFGAP2
    ThermoFisher Antibody for ARFGAP2
    LSBio Antibodies in human, mouse, rat for ARFGAP2

    ARFGAP2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ARFGAP2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARFGAP2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ARFGAP2
    Cloud-Clone Corp. CLIAs for ARFGAP2
    Search eBioscience for ELISAs for ARFGAP2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ArfGAP: ADP-ribosylation factor GTPase activating proteins

    1 InterPro protein domain:
     IPR001164 ArfGAP

    Graphical View of Domain Structure for InterPro Entry Q8N6H7

    ProtoNet protein and cluster: Q8N6H7

    1 Blocks protein domain: IPB001164 HIV Rev interacting protein signature

    UniProtKB/Swiss-Prot: ARFG2_HUMAN, Q8N6H7
    Similarity: Contains 1 Arf-GAP domain


    Find genes that share domains with ARFGAP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARFG2_HUMAN, Q8N6H7
    Function: GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated
    protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead
    to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008060ARF GTPase activator activity IEA--
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with ARFGAP2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ARFGAP2:
     Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARFGAP2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARFGAP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARFGAP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARFGAP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ARFGAP2:
    hsa-mir-324-5p (MIRT043179), hsa-mir-183-5p (MIRT025024)

    Block miRNA regulation of human, mouse, rat ARFGAP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARFGAP2 (see all 18):
    hsa-miR-15a hsa-miR-132 hsa-miR-424 hsa-miR-129-3p hsa-miR-514b-3p hsa-miR-212 hsa-miR-195 hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidARFGAP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ARFGAP2
    Predesigned siRNA for gene silencing in human, mouse, rat ARFGAP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ARFGAP2

    Clone
    Products:
         
    OriGene clones in human, mouse for ARFGAP2 (see all 8)
    OriGene ORF clones in mouse, rat for ARFGAP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARFGAP2 (NM_032389)
    Sino Biological Human cDNA Clone for ARFGAP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARFGAP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARFGAP2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ARFGAP2
    Browse ESI BIO Cell Lines and PureStem Progenitors for ARFGAP2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARFGAP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ARFG2_HUMAN, Q8N6H7: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
    Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate
    compartment
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol4
    nucleus4

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with ARFGAP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ARFGAP2 About    
    See pathways by source

    SuperPathContained pathways About
    1Endocytosis
    Endocytosis


    Find genes that share SuperPaths with ARFGAP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for ARFGAP2):
        Endocytosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARFGAP2
    Interactions:

        Search GeneGlobe Interaction Network for ARFGAP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARFGAP2 (ENSP000003273094) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPB1ENSP000002499234STRING: ENSP00000249923
    COPG1ENSP000003250024STRING: ENSP00000325002
    COPB2ENSP000003294194STRING: ENSP00000329419
    COPAENSP000003570484STRING: ENSP00000357048
    POLR3BENSP000002283474STRING: ENSP00000228347
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--
    GO:0016192vesicle-mediated transport IEA--
    GO:0032312regulation of ARF GTPase activity IEA--

    Find genes that share ontologies with ARFGAP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARFGAP2 (ARFG2)

    1 HMDB Compound for ARFGAP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ARFGAP2 gene (2 alternative transcripts): 
    NM_001242832.1  NM_032389.4  

    Unigene Cluster for ARFGAP2:

    ADP-ribosylation factor GTPase activating protein 2
    Hs.436204  [show with all ESTs]
    Unigene Representative Sequence: NM_032389
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000524782(uc010rha.2 uc001ndt.3 uc010rhb.2 uc001ndu.3 uc010rhc.2)
    ENST00000395449 ENST00000533243 ENST00000527776 ENST00000526342 ENST00000527927
    ENST00000532478 ENST00000525635 ENST00000532438 ENST00000529455 ENST00000525398
    ENST00000526948 ENST00000531750 ENST00000525314 ENST00000527097 ENST00000528444
    ENST00000524727(uc010rhd.2) ENST00000529599
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ARFGAP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARFGAP2 (see all 18):
    hsa-miR-15a hsa-miR-132 hsa-miR-424 hsa-miR-129-3p hsa-miR-514b-3p hsa-miR-212 hsa-miR-195 hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidARFGAP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ARFGAP2
    Predesigned siRNA for gene silencing in human, mouse, rat ARFGAP2
    Clone
    Products:
         
    OriGene clones in human, mouse for ARFGAP2 (see all 8)
    OriGene ORF clones in mouse, rat for ARFGAP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARFGAP2 (NM_032389)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARFGAP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARFGAP2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ARFGAP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARFGAP2
      QuantiTect SYBR Green Assays in human, mouse, rat ARFGAP2
      QuantiFast Probe-based Assays in human, mouse, rat ARFGAP2

    Additional mRNA sequence: 

    AB073358.1 AK027482.1 AK098324.1 AK129511.1 AK300347.1 AK301785.1 AK304541.1 AK315992.1 
    AL834337.1 BC030148.2 BC036823.1 

    Selected DOTS entries (see all 39):

    DT.100879099  DT.97778051  DT.427417  DT.85101178  DT.95212488  DT.120707572  DT.100879103  DT.95212494 
    DT.100879078  DT.95148560  DT.97860165  DT.120707642  DT.97860166  DT.91774067  DT.100031497  DT.120707451 
    DT.99972933  DT.40221227  DT.87014096  DT.95212467  DT.95212489  DT.92029432  DT.95212472  DT.100662537 

    Selected AceView cDNA sequences (see all 713):

    BQ890249 BE275083 AV645750 AW087322 BM480422 CR595171 BU789328 BQ614613 
    BM471924 CA312434 CR613894 AI251129 CA309915 BX364814 AI270014 BQ941650 
    CB113119 BC007914 CR600161 BM463648 BM480257 BM833030 AU279596 BQ108639 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARFGAP2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                    -           -     -     -     -     -                       -                                       
    SP2:                    -           -     -                                                                                 
    SP3:                    -           -                                                                                       
    SP4:                    -                                                                                                   
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for ARFGAP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ARFGAP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGGTCTTG
    ARFGAP2 Expression
    About this image


    ARFGAP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ARFGAP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARFGAP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436204
        Custom PCR Arrays for ARFGAP2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ARFGAP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARFGAP2
    QuantiTect SYBR Green Assays in human, mouse, rat ARFGAP2
    QuantiFast Probe-based Assays in human, mouse, rat ARFGAP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARFGAP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARFGAP2 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arfgap21 , 5 ADP-ribosylation factor GTPase activating protein 21, 5 88.97(n)1
    92.69(a)1
      2 (50.62 cM)5
    770381  NM_023854.21  NP_076343.21 
     912649745 
    chicken
    (Gallus gallus)
    Aves ARFGAP21 ADP-ribosylation factor GTPase activating protein 2 77.24(n)
    81.43(a)
      423187  NM_001033871.2  NP_001029043.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 8)
    Uncharacterized protein
    (see all 8)
    73(a)
    66(a)
    (see all 8)
    1 ↔ many
    1 ↔ many
    (see all 8)
    1(43580704-43599325)
    5(72864374-72865195)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.60002 Transcribed sequence with weak similarity to protein more 77.15(n)    BX708862.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa11e072 wufa11e07 77.94(n)   334995  CA472676.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ArfGAP31 ADP-ribosylation factor GTPase activating protein 3 50.43(n)
    43.09(a)
      40487  NM_001104193.2  NP_001097663.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F07F6.41 F07F6.4 48.01(n)
    41.09(a)
      173927  NM_062628.4  NP_495029.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GLO3(YER122C)4 ADP-ribosylation factor GTPase activating protein (ARF more   --   5(404352-402871) 856859  NP_011048.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RPA1 RPA 51.34(n)
    49.84(a)
      818088  NM_129074.2  NP_565801.1 
    barley
    (Hordeum vulgare)
    Liliopsida Hv.51062 Transcribed sequence with weak similarity to protein more 73.79(n)    BI950554.1 


    ENSEMBL Gene Tree for ARFGAP2 (if available)
    TreeFam Gene Tree for ARFGAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ARFGAP2 gene
    ARFGAP32  
    8 SIMAP similar genes for ARFGAP2 using alignment to 19 protein entries:     ARFG2_HUMAN (see all proteins):
    ARFGAP3    ARFGAP1    AGAP8    ASAP1    AGAP1    ADAP2
    GIT1    SMAP1

    Find genes that share paralogs with ARFGAP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ARFGAP2 (see all 430)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs47529681,2
    C,F,A--46884443(+) CTCCCG/AAAGTG 2 -- int12Minor allele frequency- A:0.50NA 4
    rs47529691,2
    C,F,A,H--46884496(+) TTCTTA/GAACTC 2 -- int124Minor allele frequency- G:0.34NA NS EA CSA WA 2491
    rs1999366321,2
    --46884608(+) GCCAGC/TTCTTT 2 -- int10--------
    rs2002975761,2
    C--46884621(+) TCTGCG/ATGCCA 2 -- int11Minor allele frequency- A:0.00EU 1059
    rs1500539181,2
    C,F--46884653(+) GCACCG/AGACCT 2 -- int11Minor allele frequency- A:0.00NA 4550
    rs110391141,2
    C,F,H--46884666(+) CGGCAG/ACACAG 2 -- int118Minor allele frequency- A:0.16NS EA NA EU 7592
    rs1389079901,2
    F--46884724(+) AGGCCC/TTGGAG 2 -- int11Minor allele frequency- T:0.00NA 4446
    rs1480269971,2
    C--46884755(+) ACCGAC/TGCCCT 2 -- int11Minor allele frequency- T:0.00NA 4400
    rs2011726471,2
    --46884777(+) TGGGAC/GCCCAG 2 -- int10--------
    rs2018008741,2
    C--46884800(+) GGGGCC/TGCACT 2 -- int11Minor allele frequency- T:0.00EU 439

    HapMap Linkage Disequilibrium report for ARFGAP2 (47185848 - 47198676 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ARFGAP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897323CNV Loss21882294
    nsv897324CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARFGAP2
    DNA2.0 Custom Variant and Variant Library Synthesis for ARFGAP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606908    OMIM disorders: --


    Find genes that share disorders with ARFGAP2           About GenesLikeMe


    Export disorders for ARFGAP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ARFGAP2 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with ARFGAP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gamma-COP appendage domain -- structure and function. (PubMed id 14690497)1, 2, 3 Watson P.J.... Owen D.J. (Traffic 2004)
    2. Two human ARFGAPs associated with COP-I-coated vesicles. (PubMed id 17760859)1, 2 Frigerio G.... Duden R. (Traffic 2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. (PubMed id 12880961)1, 2 Ohira M.... Nakagawara A. (Cancer Lett. 2003)
    6. Molecular cloning and characterization of a zinc finger protein involved in Id-1-stimulated mammary epithelial cell growth. (PubMed id 11278321)1, 3 Singh J....Desprez P.Y. (J. Biol. Chem. 2001)
    7. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    8. Distinct role of subcomplexes of the COPI coat in the regulation of ArfGAP2 activity. (PubMed id 22375848)1 Pevzner I....Cassel D. (Traffic 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 84364 HGNC: 13504 AceView: PACSIN3andZNF289 Ensembl:ENSG00000149182 euGenes: HUgn84364
    ECgene: ARFGAP2 Kegg: 84364 H-InvDB: ARFGAP2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ARFGAP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ARFGAP2 gene:
    Search GeneIP for patents involving ARFGAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ARFGAP2   OriGene RNAi products in human, mouse, rat for ARFGAP2  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ARFGAP2  
     OriGene qSTAR qPCR primer pairs in human, mouse for ARFGAP2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ARFGAP2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ARFGAP2   OriGene Custom Protein Services for ARFGAP2  

     
     
     Block miRNA regulation of human, mouse, rat ARFGAP2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ARFGAP2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARFGAP2 Predesigned siRNA for gene silencing in human, mouse, rat ARFGAP2
     QuantiFast Probe-based Assays in human, mouse, rat ARFGAP2 QuantiTect SYBR Green Assays in human, mouse, rat ARFGAP2
     Custom PCR Arrays for ARFGAP2 Search Chromatin IP Primers for ARFGAP2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARFGAP2  Search GeneGlobe Interaction Network for ARFGAP2
     Regulatory tfbs in ARFGAP2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ARFGAP2 GenScript cDNA clones with any tag delivered in your preferred vector for ARFGAP2
     GenScript Custom Assay Services for ARFGAP2 GenScript Custom overexpressing Cell Line Services for ARFGAP2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ARFGAP2 (ARFG2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for ARFGAP2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ARFGAP2 antibodies
     ARFGAP2 proteins
     ARFGAP2 lysates
     Search for Antibodies for ARFGAP2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ARFGAP2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ARFGAP2
     Antibodies for ARFGAP2
     ELISAs for ARFGAP2
     CLIAs for ARFGAP2



     Browse ESI BIO Cell Lines and PureStem Progenitors for ARFGAP2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARFGAP2
     SwitchGear 3'UTR luciferase reporter plasmids for ARFGAP2
     SwitchGear Promoter luciferase reporter plasmids for ARFGAP2
     ThermoFisher Antibody for ARFGAP2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARFGAP2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARFGAP2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARFGAP2
     LSBio Antibodies in human, mouse, rat for ARFGAP2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for ARFGAP2
      Search eBioscience for proteins for ARFGAP2
      Search eBioscience for elisas for ARFGAP2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ARFGAP2 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4