Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARFGAP1 Gene

Aliases for ARFGAP1 Gene

  • ADP-Ribosylation Factor GTPase Activating Protein 1 2 3
  • ARF1-Directed GTPase-Activating Protein 3 4
  • ARF1GAP 3 4
  • ADP-Ribosylation Factor 1 GTPase Activating Protein 2
  • ADP-Ribosylation Factor GTPase-Activating Protein 1 3
  • ADP-Ribosylation Factor 1 GTPase-Activating Protein 4
  • HRIHFB2281 3
  • ARF GAP 1 4
  • ARF1 GAP 4

External Ids for ARFGAP1 Gene

Previous HGNC Symbols for ARFGAP1 Gene

  • ARF1GAP

Previous GeneCards Identifiers for ARFGAP1 Gene

  • GC20P061781
  • GC20P062583
  • GC20P062630
  • GC20P061374
  • GC20P061904
  • GC20P058629

Summaries for ARFGAP1 Gene

Entrez Gene Summary for ARFGAP1 Gene

  • The protein encoded by this gene is a GTPase-activating protein, which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for ARFGAP1 Gene

ARFGAP1 (ADP-Ribosylation Factor GTPase Activating Protein 1) is a Protein Coding gene. Among its related pathways are GPCR Pathway and PAK Pathway. GO annotations related to this gene include GTPase activator activity.

UniProtKB/Swiss-Prot for ARFGAP1 Gene

  • GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicles fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity).

Gene Wiki entry for ARFGAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARFGAP1 Gene

Genomics for ARFGAP1 Gene

Regulatory Elements for ARFGAP1 Gene

Genomic Location for ARFGAP1 Gene

Start:
63,272,785 bp from pter
End:
63,289,793 bp from pter
Size:
17,009 bases
Orientation:
Plus strand

Genomic View for ARFGAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARFGAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARFGAP1 Gene

Proteins for ARFGAP1 Gene

  • Protein details for ARFGAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6T3-ARFG1_HUMAN
    Recommended name:
    ADP-ribosylation factor GTPase-activating protein 1
    Protein Accession:
    Q8N6T3
    Secondary Accessions:
    • B7Z3U0
    • B7Z8H8
    • B7ZBI3
    • E1P5I9
    • E7EV62
    • Q6PK71
    • Q96KC4
    • Q96T02
    • Q9NSU3
    • Q9NVF6
    • Q9UIL0

    Protein attributes for ARFGAP1 Gene

    Size:
    406 amino acids
    Molecular mass:
    44668 Da
    Quaternary structure:
    • Interacts with ARF1. Interacts with the COPI coat proteins, KDELR1 and TMED2. The interaction with TMED2 inhibits the GAP activity (By similarity).
    SequenceCaution:
    • Sequence=BAB55009.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55113.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB70901.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARFGAP1 Gene

    Alternative splice isoforms for ARFGAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARFGAP1 Gene

Proteomics data for ARFGAP1 Gene at MOPED

Post-translational modifications for ARFGAP1 Gene

  • Ubiquitination at Lys102 and Lys278
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARFGAP1 Gene

Domains for ARFGAP1 Gene

Gene Families for ARFGAP1 Gene

HGNC:
  • ArfGAP :ADP-ribosylation factor GTPase activating proteins

Protein Domains for ARFGAP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N6T3

UniProtKB/Swiss-Prot:

ARFG1_HUMAN :
  • Q8N6T3
Domain:
  • The region downstream of Arf-GAP domain is essential to GAP activity in vivo. This region may be required for its targeting to Golgi membranes (By similarity).
  • Contains 1 Arf-GAP domain.
genes like me logo Genes that share domains with ARFGAP1: view

Function for ARFGAP1 Gene

Molecular function for ARFGAP1 Gene

UniProtKB/Swiss-Prot Function: GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicles fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity).

Gene Ontology (GO) - Molecular Function for ARFGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA 22423108
GO:0005515 protein binding IPI 22363216
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ARFGAP1: view

Phenotypes for ARFGAP1 Gene

GenomeRNAi human phenotypes for ARFGAP1:
genes like me logo Genes that share phenotypes with ARFGAP1: view

miRNA for ARFGAP1 Gene

miRTarBase miRNAs that target ARFGAP1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARFGAP1 Gene

Localization for ARFGAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARFGAP1 Gene

Cytoplasm. Golgi apparatus. Note=Associates with the Golgi complex. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARFGAP1 Gene COMPARTMENTS Subcellular localization image for ARFGAP1 gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 4
golgi apparatus 4
nucleus 4
plasma membrane 4

Gene Ontology (GO) - Cellular Components for ARFGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane --
GO:0005829 cytosol TAS --
GO:0030660 Golgi-associated vesicle membrane TAS --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with ARFGAP1: view

Pathways for ARFGAP1 Gene

genes like me logo Genes that share pathways with ARFGAP1: view

Pathways by source for ARFGAP1 Gene

2 Qiagen pathways for ARFGAP1 Gene
1 BioSystems pathway for ARFGAP1 Gene

Gene Ontology (GO) - Biological Process for ARFGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0006987 activation of signaling protein activity involved in unfolded protein response --
GO:0015031 protein transport IEA --
GO:0030968 endoplasmic reticulum unfolded protein response TAS --
GO:0036498 IRE1-mediated unfolded protein response TAS --
genes like me logo Genes that share ontologies with ARFGAP1: view

Compounds for ARFGAP1 Gene

(1076) HMDB Compounds for ARFGAP1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
PC(14:0/14:0)
  • Phosphatidylcholine(14:0/14:0)
Not Available
PC(14:0/14:1(9Z))
  • Phosphatidylcholine(14:0/14:1)
Not Available
PC(14:0/15:0)
  • GPCho(14:0/15:0)
Not Available
PC(14:0/16:0)
  • GPCho(30:0)
Not Available

(2) Novoseek inferred chemical compound relationships for ARFGAP1 Gene

Compound -log(P) Hits PubMed IDs
gtp 48 3
lipid 0 2
genes like me logo Genes that share compounds with ARFGAP1: view

Transcripts for ARFGAP1 Gene

Unigene Clusters for ARFGAP1 Gene

ADP-ribosylation factor GTPase activating protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARFGAP1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - -
SP8: - -
SP9: -
SP10:
SP11: - - - - - - - - - - - - - - - - - - -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

ExUns: 15c · 15d ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - - -
SP11: - - - - - -
SP12:
SP13: - - -
SP14:
SP15:
SP16:
SP17:

Relevant External Links for ARFGAP1 Gene

GeneLoc Exon Structure for
ARFGAP1
ECgene alternative splicing isoforms for
ARFGAP1

Expression for ARFGAP1 Gene

mRNA expression in normal human tissues for ARFGAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARFGAP1 Gene

SOURCE GeneReport for Unigene cluster for ARFGAP1 Gene Hs.25584

genes like me logo Genes that share expressions with ARFGAP1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARFGAP1 Gene

Orthologs for ARFGAP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARFGAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARFGAP1 35
  • 99.01 (n)
  • 98.28 (a)
ARFGAP1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARFGAP1 35
  • 83.77 (n)
  • 84.55 (a)
ARFGAP3 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARFGAP1 35
  • 85.14 (n)
  • 83.74 (a)
ARFGAP1 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arfgap1 35
  • 85.77 (n)
  • 87.34 (a)
Arfgap1 16
Arfgap1 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARFGAP1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARFGAP1 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arfgap1 35
  • 84.57 (n)
  • 86.14 (a)
chicken
(Gallus gallus)
Aves ARFGAP1 35
  • 74.36 (n)
  • 78.41 (a)
ARFGAP1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARFGAP1 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25766 35
tropical clawed frog
(Silurana tropicalis)
Amphibia arfgap1 35
  • 71.7 (n)
  • 71.87 (a)
zebrafish
(Danio rerio)
Actinopterygii arfgap1 35
  • 64.82 (n)
  • 64.91 (a)
ARFGAP1 36
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Gap69C 36
  • 33 (a)
OneToOne
CG6838 37
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea K02B12.7 36
  • 39 (a)
OneToOne
F07F6.4 37
  • 37 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL164C 35
  • 50 (n)
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GCS1 35
  • 48.15 (n)
  • 36.2 (a)
GCS1 36
  • 27 (a)
OneToMany
GCS1 38
SPS18 36
  • 18 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18942g 35
  • 47.73 (n)
  • 36.74 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07734 35
  • 46.12 (n)
  • 34.75 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC622.14 35
  • 43.56 (n)
  • 33.71 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11804 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6254 36
  • 43 (a)
OneToOne
Species with no ortholog for ARFGAP1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARFGAP1 Gene

ENSEMBL:
Gene Tree for ARFGAP1 (if available)
TreeFam:
Gene Tree for ARFGAP1 (if available)

Paralogs for ARFGAP1 Gene

genes like me logo Genes that share paralogs with ARFGAP1: view

No data available for Paralogs for ARFGAP1 Gene

Variants for ARFGAP1 Gene

Sequence variations from dbSNP and Humsavar for ARFGAP1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs13865 -- 63,288,129(+) GGACT(C/T)AAGGC utr-variant-3-prime, nc-transcript-variant
rs911065 -- 63,283,113(+) ACTGC(A/G)GCCGG intron-variant, upstream-variant-2KB
rs927132 -- 63,276,267(+) ACACC(A/G)GAGGT intron-variant
rs1543449 -- 63,290,180(+) CCCCC(C/T)ATGCT downstream-variant-500B
rs2236195 -- 63,281,363(+) GCCCC(C/T)GCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARFGAP1 Gene

Variant ID Type Subtype PubMed ID
nsv913073 CNV Loss 21882294
nsv9825 CNV Gain 18304495
dgv4618n71 CNV Loss 21882294
nsv913161 CNV Loss 21882294
nsv913165 CNV Loss 21882294
nsv913166 CNV Loss 21882294
dgv4626n71 CNV Loss 21882294
dgv4627n71 CNV Loss 21882294
dgv4628n71 CNV Loss 21882294
dgv4629n71 CNV Loss 21882294
nsv834032 CNV Loss 17160897
nsv470560 CNV Loss 18288195
nsv525279 CNV Loss 19592680
nsv913177 CNV Loss 21882294
dgv4630n71 CNV Loss 21882294
nsv3446 CNV Loss 18451855
nsv913181 CNV Loss 21882294
dgv4631n71 CNV Loss 21882294
nsv913183 CNV Loss 21882294
dgv4632n71 CNV Loss 21882294
esv2722903 CNV Deletion 23290073

Relevant External Links for ARFGAP1 Gene

HapMap Linkage Disequilibrium report
ARFGAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARFGAP1 Gene

Disorders for ARFGAP1 Gene

No disorders were found for ARFGAP1 Gene.

No data available for UniProtKB/Swiss-Prot for ARFGAP1 Gene

Publications for ARFGAP1 Gene

  1. The KDEL receptor, ERD2, regulates intracellular traffic by recruiting a GTPase-activating protein for ARF1. (PMID: 9405360) Aoe T. … Hsu V.W. (EMBO J. 1997) 3 23
  2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4
  3. Expression, purification, and properties of ADP-ribosylation factor (ARF) GTPase activating protein-1. (PMID: 11210549) Huber I. … Cassel D. (Meth. Enzymol. 2001) 2 3
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ARFGAP1 Gene

Sources for ARFGAP1 Gene

Back to Top

Content