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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARF6 Gene

protein-coding   GIFtS: 65
GCID: GC14P050359

ADP-ribosylation factor 6
 Explore 11 diseases affiliated with
ARF6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ARF6    

Aliases
for ARF6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ADP-Ribosylation Factor 61 2

External Ids:    HGNC: 6591   Entrez Gene: 3822   Ensembl: ENSG000001655277   OMIM: 6004645   UniProtKB: P623303   

Export aliases for ARF6 gene to outside databases

Previous GC identifers: GC14P047681 GC14P044155 GC14P048349 GC14P049429 GC14P030484


Summaries
for ARF6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ARF6:
This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode
small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play
a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the
plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead
to actin remodeling. A pseudogene of this gene is located on chromosome 7. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ARF6_HUMAN, P62330
Function: GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton
remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric
activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic
spine development (By similarity). Contributes to the regulation of dendritic branching and filopodia extension

Gene Wiki entry for ARF6


Genomic Views
for ARF6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARF6 gene promoter:
         HOXA9   AP-1   ATF-2   USF-1:USF-2   Nkx2-5   AREB6   USF-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ARF6 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARF6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARF6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q21.3   Ensembl cytogenetic band:  14q21.3   HGNC cytogenetic band: 14q21.3

ARF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARF6 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P050359:  view genomic region     (about GC identifiers)

Start:
 50,359,736 bp from pter      End:
 50,363,772 bp from pter
Size:
 4,037 bases      Orientation:
 plus strand

Proteins
for ARF6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ARF6_HUMAN, P62330 (See protein sequence)
Recommended Name: ADP-ribosylation factor 6  
Size: 175 amino acids; 20082 Da
Subunit: Interacts with ARHGAP21, ASAP2, HERC1, PIP5K1C and UACA. Interacts with NCS1/FREQ at the plasma membrane.
Interacts with RAB11FIP3 and RAB11FIP4. Interacts with USP6 (via Rab-GAP TBC domain). Interacts with ECM29. Interacts
with TBC1D24
Subcellular location: Golgi apparatus. Cell membrane; Lipid-anchor. Endosome membrane; Lipid-anchor. Cell membrane.
Cell projection, filopodium membrane; Lipid-anchor. Note=Recruited to the cell membrane in association with CYTH2 and
ARL4C
6/13 PDB 3D structures from and Proteopedia for ARF6 (see all 13):
1E0S (3D)        2A5D (3D)        2A5F (3D)        2A5G (3D)        2BAO (3D)        2BAU (3D)    
Secondary accessions: P26438 Q6FGZ2

Explore the universe of human proteins at neXtProt for ARF6: NX_P62330

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P62330

    • ARF6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001654.1  
    ENSEMBL proteins: 
     ENSP00000298316  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein: ARF6
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    Novus Biologicals ARF6 Proteins
    Novus Biologicals ARF6 Lysate
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    ProSpec Recombinant Protein for ARF6
    Uscn Proteins for ARF6

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IDA9312003
    GO:0005624membrane fraction ----
    GO:0005737cytoplasm ----
    GO:0005768endosome TAS10913182
    GO:0005769early endosome IEA--


    ARF6 for ontologies           About GeneDecksing



    ARF6 Antibody Products: 
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    ThermoFisher Antibody for ARF6

    Assay Products for ARF6: 
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    Uscn ELISAs and CLIAs for ARF6

    Protein Domains /
    Families
    for ARF6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ARF6 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF
     IPR005225 Small_GTP-bd_dom

    Graphical View of Domain Structure for InterPro Entry P62330

    ProtoNet protein and cluster: P62330

    UniProtKB/Swiss-Prot: ARF6_HUMAN, P62330
    Similarity: Belongs to the small GTPase superfamily. Arf family


    Function
    for ARF6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ARF6_HUMAN, P62330
    Function: GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton
    remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric
    activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic
    spine development (By similarity). Contributes to the regulation of dendritic branching and filopodia extension

         Genatlas biochemistry entry for ARF6:
    ADP ribosylation factor 6,class III,low molecular weight,widely expressed,involved in vesicular trafficking,activator
    of PIP5K1A

    miRNA
    Products:            		 OriGene 3'-UTR Clone: ARF6
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARF6
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate ARF6 (see all 33):
    hsa-miR-124* hsa-miR-323-3p hsa-miR-520f hsa-miR-139-5p hsa-miR-218 hsa-miR-500a hsa-miR-3161 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmid: ARF6 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARF6 (see all 7)
    OriGene shRNA RFP: ARF6
    OriGene siRNA: ARF6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARF6

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ARF6

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARF6 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARF6
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ARF6 (NM_001663)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARF6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARF6 

    Cell Line
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    Search LifeMap BioReagents cell lines for ARF6

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARF6

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS1993656
    GO:0005515protein binding IPI16415858
    GO:0005525GTP binding TAS10913182
    GO:0031996thioesterase binding IPI15509780


    ARF6 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ARF6:
     Increased Salmonella enterica   Increased Salmonella enterica  

    Animal Models:
         Mouse knock-out Arf6tm1Yaka for ARF6
         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Arf6):
     cardiovascular system  hematopoietic system  homeostasis/metabolism  liver/biliary system  mortality/aging 

    ARF6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ARF6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune response CD16 signaling in NK cells
    		Immune response CD16 signaling in NK cells1.00
    		Immune response_CD16 signaling in NK cells0.99
    2Paxillin-independent events mediated by a4b1 and a4b7
    		Paxillin-independent events mediated by a4b1 and a4b71.00
    		Paxillin-dependent events mediated by a4b10.58
    3Protein Stability
    		Protein Stability1.00
    4Cytoskeletal Signaling
    		Cytoskeletal Signaling1.00
    5Remodeling of Adherens Junctions
    		Remodeling of Adherens Junctions1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ARF6
        Immune response CD16 signaling in NK cells

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ARF6
        Cholera Infection
    Paxillin Interactions
    Remodeling of Adherens Junctions
    Fc-GammaR-Mediated Phagocytosis in Macrophages

    2 Cell Signaling Technology (CST) Pathways for ARF6
        Cytoskeletal Signaling
    Protein Stability

    1 GeneGo (Thomson Reuters) Pathway for ARF6
        Immune response CD16 signaling in NK cells

    5/10 BioSystems Pathways for ARF6 (see all 10) 
        Insulin Signaling
    Arf6 trafficking events
    Stabilization and expansion of the E-cadherin adherens junction
    Paxillin-independent events mediated by a4b1 and a4b7
    E-cadherin signaling in the nascent adherens junction


    2         Kegg Pathways  (Kegg details for ARF6):
        Endocytosis
    Fc gamma R-mediated phagocytosis


    ARF6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARF6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/209 Interacting proteins for ARF6 (P623301, 2, 3 ENSP000002983164) via UniProtKB, MINT, STRING, and/or I2D (see all 209)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPAG9O602712, 3, ENSP000002620134MINT-7922407 MINT-7922423 MINT-7922498 MINT-7922449 MINT-7922462 MINT-7922481 MINT-7922515 MINT-7915283 I2D: score=3 STRING: ENSP00000262013
    KIF23Q022412MINT-8397642 MINT-8398021 MINT-8397725 MINT-8397742 MINT-8397810 MINT-8397759 MINT-8397988 MINT-8397913 MINT-8397949 MINT-8395820 MINT-8397844 MINT-8397776 MINT-8398039 MINT-8397691 MINT-8397969 MINT-8397669 MINT-8397793 MINT-8397827 MINT-8398059 MINT-8397708 MINT-8398005 MINT-8397899 MINT-8400598
    ARFIP2P533651, 3, ENSP000002545844EBI-2802827,EBI-638194 I2D: score=4 STRING: ENSP00000254584
    ATP6V1C1P212831, 3, ENSP000003792034EBI-2802827,EBI-988663 I2D: score=3 STRING: ENSP00000379203
    ZNF709Q8N9723, ENSP000003808404I2D: score=1 STRING: ENSP00000380840
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001889liver development IEA--
    GO:0006184GTP catabolic process TAS1993656
    GO:0006915apoptotic process IEA--
    GO:0006928cellular component movement TAS10036235
    GO:0007155cell adhesion TAS10036235


    ARF6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ARF6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ARF6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARF6

    1 HMDB Compound for ARF6    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    3 DrugBank Compounds for ARF6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    5'-Guanosine-Diphosphate-Monothiophosphate-- --target--17139284 17016423 10592235
    Guanosine-5'-Diphosphate-- 146-91-8target--17139284 17016423 10592235
    MYRISTIC ACID-- --target--10592235

    10/28 Novoseek chemical compound relationships for ARF6 gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    grp-1 86.7 18 10480924 (6), 9832437 (1), 17409355 (1), 18042453 (1)
    gtp 77.1 68 10480924 (3), 9314528 (3), 10391955 (3), 16737952 (3) (see all 31)
    ac-ap 71.5 1 16280360 (1)
    gdp 68.6 22 16527809 (3), 15126638 (2), 11266366 (2), 10480924 (1) (see all 13)
    phosphatidylinositol-3,4,5-trisphosphate 58.5 2 10848997 (1), 10917667 (1)
    adp 56.9 23 12810696 (2), 11463641 (2), 15778454 (1), 18764822 (1) (see all 16)
    pip2 51.5 7 11535619 (3), 16413288 (2), 15817676 (1)
    phosphatidylinositol 51 13 10788515 (2), 17284522 (2), 11950936 (1), 16737952 (1) (see all 8)
    butanol 42 2 11516649 (1), 16280360 (1)
    ptdins(3)p 41.8 1 16413288 (1)

    Search CenterWatch for drugs/clinical trials and news about ARF6 

    Transcripts
    for ARF6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ARF6 gene: 
    NM_001663.3  

    Unigene Cluster for ARF6:

    ADP-ribosylation factor 6
    Hs.525330  [show with all ESTs]
    Unigene Representative Sequence: NM_001663
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000298316(uc001wxg.4)

    miRNA
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    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate ARF6 (see all 33):
    hsa-miR-124* hsa-miR-323-3p hsa-miR-520f hsa-miR-139-5p hsa-miR-218 hsa-miR-500a hsa-miR-3161 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmid: ARF6 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARF6 (see all 7)
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARF6
    Clone
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    GenScript: all cDNA clones in your preferred vector: ARF6 (NM_001663)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARF6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARF6

    Additional cDNA sequence: 

    AF047432.1 AF493885.1 AK313790.1 AL117621.1 BC002952.1 BC008918.2 BC030291.1 BT019868.1 
    CR541939.1 CR541964.1 M57763.1 

    10 DOTS entries:

    DT.455400  DT.86609000  DT.100036242  DT.91769001  DT.100796741  DT.120773507  DT.91768995  DT.95190179 
    DT.100776347  DT.102824727 

    24/422 AceView cDNA sequences (see all 422):

    AA237077 BM836058 M57763 BE049391 AW371856 CF132705 BU661396 BU675947 
    T32075 BM840608 AA098905 BE614131 AW021268 CA432745 AW571594 AI332406 
    BC008918 BM751825 AA291260 BI962741 BM541735 BU543730 CB111758 CR619019 

    GeneLoc Exon Structure


    Expression
    for ARF6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARF6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGACTATGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ARF6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/21 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 21) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbForelimb Dorsal MusclesMononuclear MyocytesSkeletal Muscle
    LimbForelimb Ventral MusclesMononuclear MyocytesSkeletal Muscle
    LimbHindlimb Dorsal MuscleMononuclear MyocytesSkeletal Muscle
    LimbHindlimb Ventral MuscleMononuclear MyocytesSkeletal Muscle
    LiverLiver BudHepatoblastsLiver
    Skeletal MuscleThoracic Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Hypaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Primary Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Primary Hypaxial MyotomeMononuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ARF6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARF6

    SOURCE GeneReport for Unigene cluster: Hs.525330

    UniProtKB/Swiss-Prot: ARF6_HUMAN, P62330
    Tissue specificity: Ubiquitous, with higher levels in heart, substantia nigra, and kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including ARF6: 
              Adherens Junctions in human mouse rat
              Cell Motility in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARF6
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARF6

    Orthologs
    for ARF6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARF6 gene from 7/32 species (see all 32)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia ARF66
    		 --
    		 99(a)
    		 1 ↔ 1
    		 GL343627.1(322866-323393)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.9632 Xenopus laevis Arf6 mRNA, complete cds 83.55(n)    U31469.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufj46d092 wufj46d09 81.23(n)   336063  BC064293.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Arf51F1 , 3 protein amino acid ADP-ribosylation GTP
    binding3
    ADP ribosylation factor 51F1    		 96(a)3
    76.63(n)1
    97.13(a)1    		   2 51F63
    366991  NM_166091.11  NP_725455.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea arf-61 , 3 Protein ARF-61 88(a)
    (best of 2)3
    73.95(n)1
    88.51(a)1    		   IV(16947228-16949812)3
    1916081  NM_070610.31  NP_503011.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes ARF3(YOR094W)4
    ARF31    		 Glucose-repressible ADP-ribosylation factor, GTPase more4
    Arf3p1    		 56.98(n)1
    60.47(a)1    		   15(502795-503346)4
    8542611, 4  NP_014737.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATARFB1A6
    ATARFD1B6
    (see all 3)    		 ADP-ribosylation factor D1B
    (see all 3)    		 47(a)
    44(a)
    (see all 3)    		 possible ortholog
    many ↔ many
    (see all 3)    		 2(6653791-6655501)
    1(495050-496062)


    ENSEMBL Gene Tree for ARF6 (if available)
    TreeFam Gene Tree for ARF6 (if available) 

    Paralogs
    for ARF6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARF6 gene
    ARL4A2  ARL112  ARF42  ARF52  ARF12  ARL4D2  ARF32  ARL142  
    ARL92  ARL17B2  ARL4C2  TRIM232  ARL102  
    18/33 SIMAP similar genes for ARF6 using alignment to 2 protein entries:     ARF6_HUMAN (see all proteins) (see all similar genes):
    ARF5    ARF1    ARF3    ARF4    ARL17A    ARL17B
    TRIM23    ARL1    ARL14    DKFZp434B2017    ARL5A    ARL4C
    ARL7    ARL3    ARL5B    ARL5C    SAR1B    ARL4A

    ARF6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ARF6
    PGOHUM00000232934


    Genomic Variants
    for ARF6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/128 NCBI SNPs in ARF6 are shown (see all 128)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1408199001,2
    		--50357762(+) CCTGGA/GCAACA 1 -- us2k10--------
    rs31009091,2
    		C,F,A,--50357912(-) AAGTGT/ATCTGC 1 -- us2k1 tfbs37Minor allele frequency- A:0.13NA WA CSA 131
    rs1928569741,2
    		--50357941(+) CCAGTC/GTGGCC 1 -- us2k10--------
    rs1501309701,2
    		--50357992(+) GTCAGA/GCGTGG 1 -- us2k10--------
    rs1158923181,2
    		F,--50358101(+) GCACTG/CCAGCC 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1834946011,2
    		--50358408(+) AAAGAC/TACCCA 1 -- us2k10--------
    rs1887852571,2
    		--50358411(+) GATACC/TCATTT 1 -- us2k10--------
    rs1928550081,2
    		--50358528(+) ACGCCC/TGTAAT 1 -- us2k10--------
    rs1128589961,2
    		C,--50358544(+) CATTTC/TGGGGG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1493108501,2
    		--50358700(+) ACTGCC/TTGAAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARF6 (50359736 - 50363772 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ARF6
         1 CNV: 66642

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    Disorders / Diseases
    for ARF6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ARF6 for disorders           About GeneDecksing

    OMIM gene information: 600464    OMIM disorders: --

    11 diseases for ARF6:    About MalaCards
    cholera    hemophagocytic lymphohistiocytosis    herpes simplex    breast cancer
    glioblastoma    lung cancer    prostate cancer    cholesterol
    prostatitis    malaria    neuronitis

    1 disease from the University of Copenhagen DISEASES database for ARF6:
    Cholera

    6 Novoseek disease relationships for ARF6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioblastoma 28 5 19642173 (2), 11226253 (1)
    cholera 19.5 3 11106366 (1), 1447192 (1), 16552056 (1)
    invasive cancer 7.62 5 15087504 (2), 16636290 (1)
    tumors 5.14 14 16413265 (5), 19896381 (4), 15210957 (2), 18094045 (1)
    breast cancer 0 20 15087504 (4), 18084281 (4), 16636290 (1), 19416474 (1) (see all 6)
    cancer 0 2 14607973 (2)


    Export disorders for ARF6 gene to outside databases

    Publications
    for ARF6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARF6 gene, integrated from 9 sources (see all 305):
    (articles sorted by number of sources associating them with ARF6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells. (PubMed id 1993656)1, 2, 3 Tsuchiya M.... Vaughan M. (1991)
    2. Sequence, genomic organization, and expression of the human ADP- ribosylation factor 6 (ARF6) gene: a class III ARF. (PubMed id 14659046)1, 2, 9 Lebeda R.A.... Haun R.S. (2003)
    3. Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis. (PubMed id 16148947)1, 2, 9 Fielding A.B.... Gould G.W. (2005)
    4. The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6. (PubMed id 15509780)1, 2, 9 Martinu L....Chou M.M. (2004)
    5. Myristoylation is required for the intracellular localization and endocytic function of ARF6. (PubMed id 7589240)1, 2, 9 D'Souza-Schorey C. and Stahl P.D. (1995)
    6. Molecular characterization of Rab11-FIP3 binding to ARF GTPases. (PubMed id 17628206)1, 2, 9 Schonteich E.... Prekeris R. (2007)
    7. The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane. (PubMed id 17398095)1, 2, 9 Hofmann I....Munro S. (2007)
    8. The structural GDP/GTP cycle of human Arf6. (PubMed id 11266366)1, 2, 9 Pasqualato S.... Cherfils J. (2001)
    9. TBC1D24, an ARF6-interacting protein, is mutated in f amilial infantile myoclonic epilepsy. (PubMed id 20727515)1, 2 Falace A....Zara F. (2010)
    10. Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1. (PubMed id 17030804)1, 2 Shiba T....Wakatsuki S. (2006)

    External Searches for ARF6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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    Genome Databases showing ARF6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 382 HGNC: 659 AceView: ARF6 Ensembl:ENSG00000165527 euGenes: HUgn382
    ECgene: ARF6 Kegg: 382 H-InvDB: ARF6

    Other Databases showing ARF6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ARF6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARF6 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ARF6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ARF6 gene:
    Search GeneIP for patents involving ARF6

    GeneCards and IP:
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