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ARF6 Gene

protein-coding GIFtS: 57

GC14P049429

ADP-ribosylation factor 6
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
DKFZp564M0264 ^²

Descriptions
ADP-ribosylation factor 6 ^²

External Ids
HGNC: 659¹
Entrez Gene: 382²
UniProtKB: P62330³
Ensembl: ENSG00000165527⁷

Search outside databases for aliases for ARF6 gene

Previous GC identifers: GC14P047681 GC14P044155 GC14P048349

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ARF6:

This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The

ARF genes encode small guanine nucleotide-binding proteins that stimulate the

ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as

activators of phospholipase D. The product of this gene is localized to the plasma membrane, and

regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead

to actin remodeling. A pseudogene of this gene is located on chromosome 7. [provided by RefSeq]

UniProtKB/Swiss-Prot: ARF6_HUMAN, P62330

Function: GTP-binding protein that functions as an allosteric activator of the cholera toxin

catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate

vesicle budding and uncoating within the Golgi apparatus

Gene Wiki entry for ARF6 (Arf6)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ARF6 gene

Entrez Gene cytogenetic band: 14q21.3 Ensembl cytogenetic band: 14q22.1 HGNC cytogenetic band: 14q21.3

ARF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P049429: (about GC identifiers)

Start:	49,429,486 bp from pter
End:	49,433,522 bp from pter
Size:	4,037 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000014.7 NT_026437.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ARF6_HUMAN, P62330 (See protein sequence)

Recommended Name: ADP-ribosylation factor 6

Size: 175 amino acids; 20082 Da

Subunit: Interacts with ARHGAP21, ASAP2, HERC1, PIP5K1C and UACA

Subcellular location: Golgi apparatus

PDB structures from and Proteopedia :

1E0S (3D)

2A5D (3D)

2A5F (3D)

2A5G (3D)

2BAO (3D)

2BAU (3D)

2J5X (3D)

Secondary accessions: P26438

REFSEQ proteins: NP_001654.1

ENSEMBL proteins:

ENSP00000298316

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ARF6, ADP Ribosylation Factor)
	Human Recombinant Proteins from Abnova (ARF6)

OriGene Purified Recombinant Human Protein: ARF6

5/8 Gene Ontology (GO) cellular component terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001726	ruffle	IDA	9312003
GO:0005622	intracellular	IEA	--
GO:0005624	membrane fraction	TAS	8702973
GO:0005737	cytoplasm	IEA	--
GO:0005768	endosome	TAS	10913182

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Antibodies for ARF6:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of ARF6
	Sigma-Aldrich Antibodies for ARF6
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for ARF6
	Antibodies from Abcam (ARF6, ADP Ribosylation Factor), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ARF6)
	Novus Biologicals Antibodies for ARF6

Assays for ARF6:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P62330

ProtoNet protein and cluster: P62330

UniProtKB/Swiss-Prot: ARF6_HUMAN, P62330

Similarity: Belongs to the small GTPase superfamily. Arf family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ARF6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ARF6)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001663

Applied Biosystems Silencer® siRNAs for ARF6

Sigma-Aldrich siRNA for ARF6

Sigma-Aldrich shRNA Panels and shRNA for ARF6

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001663
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001663
untagged cDNA clone in CMV expression vector: NM_001663

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001663

UniProtKB/Swiss-Prot: ARF6_HUMAN, P62330

Function: GTP-binding protein that functions as an allosteric activator of the cholera toxin

catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate

vesicle budding and uncoating within the Golgi apparatus

Genatlas biochemistry entry for ARF6:

ADP ribosylation factor 6,class III,low molecular weight,widely expressed,involved in vesicular

trafficking,activator of PIP5K1A

5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Arf6):

hematopoietic system

homeostasis/metabolism

lethality-prenatal/perinatal

liver/biliary system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003924	GTPase activity	TAS	1993656
GO:0005515	protein binding	IPI	9312003
GO:0005525	GTP binding	TAS	10913182

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Sigma-Aldrich "Your Favorite Gene" Pathways for ARF6 (Your Favorite Gene powered by Ingenuity)

Clathrin-mediated Endocytosis
Lipid Antigen Presentation by CD1
Integrin Signaling
Fc&gamma
Macropinocytosis

GeneDecks ARF6 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ARF6

5/123 Interacting proteins for ARF6 (P62330¹ ENSP00000298316³) via UniProtKB, MINT, and/or STRING (see all 123 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARFIP2	P53365¹, ENSP00000254584³	EBI-638181, EBI-638194 STRING (score=.995)
PABPC4	Q13310¹, ENSP00000361949³	EBI-638181, EBI-372844 STRING (score=.704)
ATP6V1C1	P21283¹	EBI-638181, EBI-988663
DHPS	P49366¹	EBI-638181, EBI-741925
DYNC1H1	Q14204¹	EBI-638181, EBI-356015

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5/12 Gene Ontology (GO) biological process terms (links to tree view) (see all 12 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001889	liver development	IEA	--
GO:0006915	apoptosis	IEA	--
GO:0006928	cell motion	TAS	10036235
GO:0007155	cell adhesion	TAS	10036235
GO:0007264	small GTPase mediated signal transduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ARF6

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ARF6
10/24 Novoseek chemical compound relationships for ARF6 gene (see all 24 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
grp-1	87.93	18	10480924 (6), 9832437 (1), 17409355 (1), 18042453 (1)
gtp	77.33	65	10480924 (3), 9314528 (3), 10391955 (3), 16737952 (3) (see all 29)
ac-ap	74.59	1	16280360 (1)
gdp	68.27	21	16527809 (3), 15126638 (2), 11266366 (2), 10480924 (1) (see all 12)
adp	57.74	22	12810696 (2), 11463641 (2), 15778454 (1), 18764822 (1) (see all 15)
phosphatidylinositol-3,4,5-trisphosphate	55.14	2	10848997 (1), 10917667 (1)
pip2	53.12	7	11535619 (3), 16413288 (2), 15817676 (1)
phosphatidylinositol	50.15	13	10788515 (2), 17284522 (2), 11950936 (1), 16737952 (1) (see all 8)
butanol	44.62	2	11516649 (1), 16280360 (1)
phosphatidylinositol 3-phosphate	44.18	1	14617802 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ARF6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ARF6)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001663

Sigma-Aldrich siRNA for ARF6

Sigma-Aldrich shRNA Panels and shRNA for ARF6

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001663

REFSEQ mRNAs for ARF6 gene:

NM_001663.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001663

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001663
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001663
                                 untagged cDNA clone in CMV expression vector: NM_001663

Additional cDNA sequence:

AF047432.1 AF493885.1 AK313790.1 AL117621.1 BC002952.1 BC008918.2 BC030291.1 BT019868.1

CR541939.1 CR541964.1 CR619019.1 M57763.1

11 DOTS entries:

DT.455400 DT.86609000 DT.100036242 DT.91769001 DT.100796741 DT.100776347 DT.120773507 DT.91768995

DT.95190179 DT.102824727 DT.97855842

24/422 AceView cDNA sequences (see all 422 ):

CA432745 AW021268 N34085 AW500468 BU661396 AA098905 CF457008 BE888369

CF135624 BU194727 CA446051 BX339473 AW571594 BU685067 AA806565 AI337720

BM836058 AI332406 AA505121 BM714048 AW014842 AW371856 BM683479 BQ315714

highest scoring ESTs for ARF6:

AF047432 AA150988 AA252864 AA252925 AA327525 AA360753 AA382214 AA436985 AA437257 AA604056

Unigene Cluster for ARF6:

ADP-ribosylation factor 6

Hs.525330 [show with all ESTs]

Unigene Representative Sequence: NM_001663

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000298316

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ARF6 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ARF6

¹ / ² / ³

10 probe-sets matching ARF6 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
54829_s_at²^{, 3}	U95-B	1	1.00	1.00	0.98	1.13	AA147881	0.60	1.00	0.82	1
43480_at²^{, 3}	U95-B	1	1.00	1.00	0.98	1.04	AI491714	0.40	1.00	0.76	1
54831_r_at²^{, 3}	U95-B	1	1.00	1.00	0.93	0.83	AA147881	0.60	1.00	0.82	1
33152_at²^{, 3}	U95-A	1	0.81	1.00	0.74	0.25	AF047432	1.00	1.00	1.00	1
224788_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AV700721	0.40	1.00	0.76	1
203311_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M57763	0.80	1.00	0.91	1
203312_x_at²^{, 3}	U133-A	1	0.73	1.00	--	--	NM_001663	0.60	1.00	0.82	1
224788_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203311_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203312_x_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--

GeneDecks ARF6 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.525330
Expression variation in blood from EXPOLDB for ARF6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ARF6 gene from 5/19 species (see all 19 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ARF6¹	--	ADP-ribosylation factor 6	97.52(n) 100(a)	490679 XM_547801.2 XP_547801.1
chimpanzee (Pan troglodytes)	ARF6¹	--	ADP-ribosylation factor 6	100(n) 100(a)	452892 XM_509935.2 XP_509935.2
cow (Bos taurus)	ARF6¹	--	ADP-ribosylation factor 6	97.52(n) 100(a)	614161 XM_865538.2 XP_870631.2
rat (Rattus norvegicus)	Arf6¹	--	ADP-ribosylation factor 6	96.57(n) 100(a)	79121 NM_024152.2 NP_077066.1
mouse (Mus musculus)	Arf6^{1, 5}	12⁵	ADP-ribosylation factor 6^{1, 5}	96(n)¹ 100(a)¹	11845¹ NM_007481.2¹ NP_031507.1¹ AA958965⁵ AI788669⁵ (see all 14)

About this table Species with no ortholog for ARF6

ENSEMBL Gene Tree for ARF6

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ARF6 gene

ARF3² ARF1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/50 NCBI SNPs in ARF6 are shown (see all 50 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 11)

AB	SNP ID	Valid	Chr 14 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3100908^1,2	A,C,F,H	49429239(-)	`GGGGGA/GCCCTA`	1	--	ng5¹		4		EU EA WA	412
	rs3126180^1,2	C,F,H	49433876(+)	`CTTAAG/ATTCAG`	1	--	ng3¹		7		EU EA WA NA	560
--	rs3100909^1,2	A,C	49427662(-)	`aagtgA/Ttctgc`	1	--	ng5¹ tfbs³		0	--	--	--	--
--	rs15382^1,2	C,F	49431088(+)	`TTTTTA/TTTTCG`	1	--	ut3¹		1		MN	184
--	rs3100898^1,2	H	49430511(-)	`GTGCAG/TCTCCT`	1	L/M	mis¹		4		EU EA WA	412
--	rs73273802^1,2	--	49429163(+)	`GGCACA/CGAGGT`	1	--	ng5¹		0	--	--	--	--
--	rs3217662^1,2	--	49431995(+)	`CATGC-/AAATAATA`	1	--	ut3¹		0	--	--	--	--
--	rs11408879^1,2	--	49429064(+)	`AAAAA-/ACAAAA`	1	--	ng5¹		0	--	--	--	--
--	rs73275406^1,2	--	49432584(+)	`CTCTTA/GACAAA`	1	--	ut3¹		0	--	--	--	--
--	rs61755564^1,2	--	49430385(+)	`TCAACA/GTATGG`	1	V/I	mis¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for ARF6 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 600464

6 Novoseek disease relationships for ARF6 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
glioblastoma	25.77	1	11226253 (1)
cholera	21.75	3	11106366 (1), 1447192 (1), 16552056 (1)
invasive cancer	10.41	5	15087504 (2), 16636290 (1)
tumors	3.77	10	16413265 (5), 15210957 (2), 18094045 (1)
cancer	0.00	2	14607973 (2)
breast cancer	0.00	19	15087504 (4), 18084281 (4), 16636290 (1), 19262097 (1) (see all 5)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/229 PubMed articles for ARF6 gene (see all 229 ):

Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells. (PubMed id 1993656)^{2, 3, 4} Tsuchiya M.... Vaughan M. (1991)
Myristoylation is required for the intracellular localization and endocytic function of ARF6. (PubMed id 7589240)^{1, 3, 4} D'Souza-Schorey C. and Stahl P.D. (1995)
The structural GDP/GTP cycle of human Arf6. (PubMed id 11266366)^{1, 3, 4} Pasqualato S.... Cherfils J. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma. (PubMed id 12847086)^{3, 4} Krauss M.... Haucke V. (2003)
Assignment of the human ADP-ribosylation factor 6 (ARF6) gene to chromosome 7q22.1 by radiation hybrid mapping. (PubMed id 10343114)^{2, 3} Kim H.S. (1999)
Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. (PubMed id 9653160)^{3, 4} Mao M....Chen Z. (1998)
Separation of membrane trafficking and actin remodeling functions of ARF6 with an effector domain mutant. (PubMed id 10913182)^{1, 3} Al-Awar O....Donaldson J.G. (2000)
Arf6 recruits the Rac GEF Kalirin to the plasma membrane facilitating Rac activation. (PubMed id 17640372)^{1, 3} Koo T.H....Donaldson J.G. (2007)
ARF6 regulates angiotensin II type 1 receptor endocytosis by controlling the recruitment of AP-2 and clathrin. (PubMed id 17719203)^{1, 3} Poupart M.E....Claing A. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 382	HGNC: 659	AceView: ARF6	Ensembl:ENSG00000165527	euGenes: HUgn382
ECgene: ARF6	H-InvDB: ARF6

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ARF6
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ARF6:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ARF6-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ARF6		Antibodies for ARF6
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ARF6		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ARF6)
	Antibodies (ARF6)
	Chimera RNAi (ARF6)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for ARF6

	Recombinant Proteins (ARF6, ADP Ribosylation Factor)
	Antibodies (ARF6, ADP Ribosylation Factor)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for ARF6

	Drugs for ARF6
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ARF6

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ARF6 Gene at Home site.
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ARF6 Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for ARF6

Summaries
for ARF6

Genomic Location
for ARF6

Proteins
for ARF6

Protein Domains/
Families
for ARF6

Gene Function
for ARF6

Pathways & Interactions
for ARF6

Drugs & Compounds
for ARF6

Transcripts
for ARF6

Expression
for ARF6

Orthologs
for ARF6

Paralogs
for ARF6

SNPs/Variants
for ARF6

Disorders & Mutations
for ARF6

Medical News
for ARF6

Publications
for ARF6

Search for ARF6

Genome Databases showing ARF6

Other Databases showing ARF6

Specialized Databases showing ARF6

Licensable Technologies
for ARF6

Services
for ARF6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ARF6 Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor ARF6

Summariesfor ARF6

Genomic Locationfor ARF6

Proteinsfor ARF6

Protein Domains/Familiesfor ARF6

Gene Functionfor ARF6

Pathways & Interactionsfor ARF6

Drugs & Compoundsfor ARF6

Transcriptsfor ARF6

Expression for ARF6

Orthologsfor ARF6

Paralogsfor ARF6

SNPs/Variantsfor ARF6

Disorders & Mutationsfor ARF6

Medical Newsfor ARF6

Publicationsfor ARF6

Search for ARF6

Genome Databases showing ARF6

Other Databases showing ARF6

Specialized Databases showing ARF6

Licensable Technologiesfor ARF6

Servicesfor ARF6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ARF6

Summaries
for ARF6

Genomic Location
for ARF6

Proteins
for ARF6

Protein Domains/
Families
for ARF6

Gene Function
for ARF6

Pathways & Interactions
for ARF6

Drugs & Compounds
for ARF6

Transcripts
for ARF6

Expression
for ARF6

Orthologs
for ARF6

Paralogs
for ARF6

SNPs/Variants
for ARF6

Disorders & Mutations
for ARF6

Medical News
for ARF6

Publications
for ARF6

Licensable Technologies
for ARF6

Services
for ARF6