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ARF5 Gene

protein-coding   GIFtS: 61
GCID: GC07P127228

ADP-Ribosylation Factor 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADP-Ribosylation Factor 51 2

External Ids:    HGNC: 6581   Entrez Gene: 3812   Ensembl: ENSG000000040597   OMIM: 1031885   UniProtKB: P840853   

Export aliases for ARF5 gene to outside databases

Previous GC identifers: GC07P125706 GC07P126771 GC07P126782 GC07P126822 GC07P127015 GC07P121589


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARF5 Gene:
This gene is a member of the human ADP-ribosylation factor (ARF) gene family. These genes encode small guanine
nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role
in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11
ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I
(ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common
gene organization. (provided by RefSeq, Dec 2010)

GeneCards Summary for ARF5 Gene:
ARF5 (ADP-ribosylation factor 5) is a protein-coding gene. Diseases associated with ARF5 include cholera, and neuroblastoma. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is ARL2.

UniProtKB/Swiss-Prot: ARF5_HUMAN, P84085
Function: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an
ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the
Golgi apparatus

Gene Wiki entry for ARF5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARF5 gene promoter:
         GATA-3   AP-1   ATF-2   Nkx2-5   GATA-2   E47   Hand1   Chx10   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARF5 promoter sequence
   Search Chromatin IP Primers for ARF5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.3   Ensembl cytogenetic band:  7q32.1   HGNC cytogenetic band: 7q31.3

ARF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARF5 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P127228:  view genomic region     (about GC identifiers)

Start:
127,228,399 bp from pter      End:
127,231,759 bp from pter
Size:
3,361 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 126,611,851-126,615,204     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ARF5_HUMAN, P84085 (See protein sequence)
Recommended Name: ADP-ribosylation factor 5  
Size: 180 amino acids; 20530 Da
Subunit: Binds ASAP2. Interacts with NCS1/FREQ at the Golgi complex. Interacts with RAB11FIP3 and RAB11FIP4
1 PDB 3D structure from and Proteopedia for ARF5:
2B6H (3D)    
Secondary accessions: P26437

Explore the universe of human proteins at neXtProt for ARF5: NX_P84085

Explore proteomics data for ARF5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys142
  • Modification sites at PhosphoSitePlus

  • See ARF5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001653.1  
    ENSEMBL proteins: 
     ENSP00000000233   ENSP00000412701  

    ARF5 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARF: ADP-ribosylation factors

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR027417 P-loop_NTPase
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF

    Graphical View of Domain Structure for InterPro Entry P84085

    ProtoNet protein and cluster: P84085

    UniProtKB/Swiss-Prot: ARF5_HUMAN, P84085
    Similarity: Belongs to the small GTPase superfamily. Arf family


    ARF5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARF5_HUMAN, P84085
    Function: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an
    ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the
    Golgi apparatus

         Genatlas biochemistry entry for ARF5:
    ADP-ribosylation factor 5,class II,20kDa,low molecular weight GTP binding protein ,a guanine nucleotide dependent
    protein activator of cholera toxin,Ras superfamily member,involved in vesicular trafficking and activation of
    phospholipase D,ubiquitously expressed (highly in pancreas,pituitary gland and placenta)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS1993656
    GO:0004871signal transducer activity ----
    GO:0005515protein binding IPI17030804
    GO:0005525GTP binding IEA--
    GO:0019001guanyl nucleotide binding ----
         
    ARF5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ARF5:
     Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARF5
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARF5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARF5

    miRNA
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    miRTarBase miRNAs that target ARF5:
    hsa-mir-99a-3p (MIRT038717), hsa-mir-18a-3p (MIRT040754)

    Block miRNA regulation of human, mouse, rat ARF5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARF5 (see all 15):
    hsa-miR-140-3p hsa-miR-4268 hsa-miR-3120-3p hsa-miR-29c hsa-miR-29a hsa-miR-331-3p hsa-miR-545 hsa-miR-1227
    SwitchGear 3'UTR luciferase reporter plasmidARF5 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ARF5
    Predesigned siRNA for gene silencing in human, mouse, rat ARF5

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: ARF5 (NM_001662)
    Sino Biological Human cDNA Clone for ARF5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARF5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARF5

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    Browse ESI BIO Cell Lines and PureStem Progenitors for ARF5 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARF5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARF5_HUMAN, P84085: Golgi apparatus. Cytoplasm, perinuclear region
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol3
    endosome2
    mitochondrion2
    plasma membrane2
    cytoskeleton1
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus IEA--
    GO:0005886plasma membrane IEA--

    ARF5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARF5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Paxillin Interactions0.73
    2Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Cholera Infection0.40
    3Class I PI3K signaling events
    Class I PI3K signaling events

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ARF5
        Cholera Infection
    Paxillin Interactions

    1 BioSystems Pathway for ARF5
        Class I PI3K signaling events



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARF5
    Interactions:

        GeneGlobe Interaction Network for ARF5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARF5 (P840852, 3 ENSP000000002334) via UniProtKB, MINT, STRING, and/or I2D (see all 675)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AP1B1Q105672, 3, ENSP000003501994MINT-7945693 I2D: score=2 STRING: ENSP00000350199
    AP3B1O002032, 3, ENSP000002551944MINT-7945693 I2D: score=1 STRING: ENSP00000255194
    CADPS2Q86UW73, ENSP000004004014I2D: score=1 STRING: ENSP00000400401
    STX6O437523, ENSP000002583014I2D: score=1 STRING: ENSP00000258301
    ARFIP2P533653, ENSP000002545844I2D: score=3 STRING: ENSP00000254584
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS1993656
    GO:0006886intracellular protein transport ----
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport IEA--

    ARF5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARF5

    1 HMDB Compound for ARF5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARF5 gene: 
    NM_001662.3  

    Unigene Cluster for ARF5:

    ADP-ribosylation factor 5
    Hs.653202  [show with all ESTs]
    Unigene Representative Sequence: BM906964
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000000233(uc003vmb.2) ENST00000463733(uc010llb.2) ENST00000415666
    ENST00000467281 ENST00000489673 ENST00000459680
    miRNA
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    Block miRNA regulation of human, mouse, rat ARF5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARF5 (see all 15):
    hsa-miR-140-3p hsa-miR-4268 hsa-miR-3120-3p hsa-miR-29c hsa-miR-29a hsa-miR-331-3p hsa-miR-545 hsa-miR-1227
    SwitchGear 3'UTR luciferase reporter plasmidARF5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARF5
    Clone
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    GenScript: all cDNA clones in your preferred vector: ARF5 (NM_001662)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARF5
    Primer
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    OriGene qPCR primer pairs and template standards for ARF5
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ARF5
      QuantiTect SYBR Green Assays in human, mouse, rat ARF5
      QuantiFast Probe-based Assays in human, mouse, rat ARF5

    Additional mRNA sequence: 

    AF493884.1 AK297026.1 AK307297.1 AK308548.1 AK312107.1 BC003043.1 BC033104.1 BT007087.1 
    M57567.1 

    11 DOTS entries:

    DT.100706330  DT.92447201  DT.100827829  DT.100827826  DT.121066998  DT.92447197  DT.454053  DT.40107473 
    DT.100827828  DT.100827833  DT.95351204 

    Selected AceView cDNA sequences (see all 446):

    CB141277 W58498 AL560575 CA454689 CB216822 AA341503 BQ687628 BG739913 
    CR614865 AI359961 BF525932 BE613454 BQ083803 BM873852 CR624513 BG751396 
    CN482940 W04254 H58464 CA488301 CB051137 BG107017 AA352555 AA337451 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARF5 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:                          -     -                       -     -     -                                       
    SP2:                          -     -           -     -     -     -     -                                       
    SP3:                                                        -     -     -                                       
    SP4:                          -     -                                                                           
    SP5:                                -                                                                           


    ECgene alternative splicing isoforms for ARF5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARF5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTCTCTGT
    ARF5 Expression
    About this image

    ARF5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARF5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.653202
        Custom PCR Arrays for ARF5
    Primer
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    QuantiTect SYBR Green Assays in human, mouse, rat ARF5
    QuantiFast Probe-based Assays in human, mouse, rat ARF5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARF5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARF5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arf51 , 5 ADP-ribosylation factor 51, 5 94.26(n)1
    100(a)1
      6 (11.99 cM)5
    118441  NM_007480.11  NP_031506.11 
     284235605 
    zebrafish
    (Danio rerio)
    Actinopterygii BC047804.12   -- 78.08(n)   321259  BC047804.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Arf102F3 protein amino acid ADP-ribosylation GTP
    binding
    83(a)
    (best of 2)
      4 102D4   --
    worm
    (Caenorhabditis elegans)
    Secernentea arf-31 , 3 GTP-binding protein3
    arf-31
    84(a)
    (best of 5)3
    71.69(n)1
    84.92(a)1
      IV(7982620-7983731)3
    1775951  NM_068935.51  NP_501336.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARF16
    ARF26
    ADP-ribosylation factor, GTPase of the Ras superfa...
    ADP-ribosylation factor, GTPase of the Ras superfa...
    69(a)
    69(a)
    many ↔ many
    many ↔ many
    IV(116321-116866) YDL192W
    IV(216529-217074) YDL137W


    ENSEMBL Gene Tree for ARF5 (if available)
    TreeFam Gene Tree for ARF5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARF5 gene
    ARL22  ARL5B2  ENSG000002730032  ARL5C2  ARF42  ENSG000002728222  ARF12  ARL32  
    ARL5A2  ARF32  ARF62  TRIM232  
    Selected SIMAP similar genes for ARF5 using alignment to 3 protein entries:     ARF5_HUMAN (see all proteins) (see all similar genes):
    ARF4    ARF1    ARF6    ARF3    ARL17A    ARL17B
    ARL1    ARL14    ARL2    ARL3    ARL4A    ARL11
    ARL4C    ARL7    ARL4D    ARL5B    ARL5A    ARL6

    ARF5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ARF5
    PGOHUM00000248647


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARF5 (see all 105)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs20735611,2
    C,F,H--127227769(+) AAGCGC/GCCAGC 1 -- us2k115Minor allele frequency- G:0.44EA NS NA WA 2626
    rs1917896651,2
    --127227937(+) GAAGCC/TAGCTA 1 -- us2k10--------
    rs132479761,2
    C,F--127227938(+) AAGCTA/TGCTAG 1 -- us2k14Minor allele frequency- T:0.08NA EA 244
    rs1840639791,2
    --127228012(+) CCTCGA/GTGGAA 1 -- us2k10--------
    rs737208571,2
    C,F--127228049(+) ACCCCT/CAATCG 1 -- us2k16Minor allele frequency- C:0.14WA NA CSA EA 364
    rs1151503371,2
    C,F--127228116(+) GGGCTA/GAAACC 1 -- us2k11Minor allele frequency- G:0.16WA 118
    rs1884059671,2
    --127228138(+) GGGCCC/TGGACG 1 -- us2k10--------
    rs1808724311,2
    --127228469(+) CCTGCA/TGCTGC 1 -- ut510--------
    rs1440862181,2
    --127228470(+) CTGCTA/GCTGCT 1 -- ut510--------
    rs125363821,2
    C,F,A,H--127228728(+) AGTCAC/TCCACC 1 -- int118Minor allele frequency- T:0.41NS EA NA CSA WA 2341

    HapMap Linkage Disequilibrium report for ARF5 (127228399 - 127231759 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ARF5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831122CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARF5
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 103188    OMIM disorders: --

    3 diseases for ARF5:    About MalaCards
    cholera    neuroblastoma    malaria

    1 disease from the University of Copenhagen DISEASES database for ARF5:
    Cholera

    ARF5 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ARF5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholera 46.1 1 1447192 (1)


    Export disorders for ARF5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARF5 gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with ARF5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells. (PubMed id 1993656)1, 2, 3 Tsuchiya M.... Vaughan M. (J. Biol. Chem. 1991)
    2. Localization and characterization of the human ADP-ribosylation factor 5 (ARF5) gene. (PubMed id 9169151)1, 2, 9 McGuire R.E.... Green E.D. (Genomics 1997)
    3. Identification of a new Pyk2 target protein with Arf-GAP activity. (PubMed id 10022920)1, 2, 9 Andreev J.... Schlessinger J. (Mol. Cell. Biol. 1999)
    4. Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1. (PubMed id 17030804)1, 2 Shiba T....Wakatsuki S. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Identification of arfophilin, a target protein for GTP-bound class II ADP-ribosylation factors. (PubMed id 10593962)1, 9 Shin O.H....Exton J.H. (J. Biol. Chem. 1999)
    7. Human and Giardia ADP-ribosylation factors (ARFs) complement ARF function in Saccharomyces cerevisiae. (PubMed id 1447192)1, 9 Lee F.J....Vaughan M. (J. Biol. Chem. 1992)
    8. Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3. (PubMed id 11926829)1, 9 Austin C....Tooze S.A. (Biochemistry 2002)
    9. Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation. (PubMed id 10589680)1, 9 Honda A....Kanaho Y. (Cell 1999)
    10. Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. (PubMed id 23464991)1 Scifo E....Lalowski M. (J. Proteome Res. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 381 HGNC: 658 AceView: ARF5andFSCN3 Ensembl:ENSG00000004059 euGenes: HUgn381
    ECgene: ARF5 H-InvDB: ARF5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ARF5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ARF5 gene:
    Search GeneIP for patents involving ARF5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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