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Aliases for ARF5 Gene

Aliases for ARF5 Gene

  • ADP Ribosylation Factor 5 2 3 5

External Ids for ARF5 Gene

Previous GeneCards Identifiers for ARF5 Gene

  • GC07P125706
  • GC07P126771
  • GC07P126782
  • GC07P126822
  • GC07P127015
  • GC07P127228
  • GC07P121589

Summaries for ARF5 Gene

Entrez Gene Summary for ARF5 Gene

  • This gene is a member of the human ADP-ribosylation factor (ARF) gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization. [provided by RefSeq, Dec 2010]

GeneCards Summary for ARF5 Gene

ARF5 (ADP Ribosylation Factor 5) is a Protein Coding gene. Diseases associated with ARF5 include cholera. Among its related pathways are Transport to the Golgi and subsequent modification and Endocytosis. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is ENSG00000272822.

UniProtKB/Swiss-Prot for ARF5 Gene

  • GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

Gene Wiki entry for ARF5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARF5 Gene

Genomics for ARF5 Gene

Regulatory Elements for ARF5 Gene

Promoters for ARF5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARF5 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARF5 Gene

Chromosome:
7
Start:
127,588,345 bp from pter
End:
127,591,705 bp from pter
Size:
3,361 bases
Orientation:
Plus strand

Genomic View for ARF5 Gene

Genes around ARF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARF5 Gene

Proteins for ARF5 Gene

  • Protein details for ARF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P84085-ARF5_HUMAN
    Recommended name:
    ADP-ribosylation factor 5
    Protein Accession:
    P84085
    Secondary Accessions:
    • P26437

    Protein attributes for ARF5 Gene

    Size:
    180 amino acids
    Molecular mass:
    20530 Da
    Quaternary structure:
    • Binds ASAP2. Interacts with NCS1/FREQ at the Golgi complex. Interacts with RAB11FIP3 and RAB11FIP4.

    Three dimensional structures from OCA and Proteopedia for ARF5 Gene

neXtProt entry for ARF5 Gene

Proteomics data for ARF5 Gene at MOPED

Post-translational modifications for ARF5 Gene

  • Ubiquitination at Lys 142
  • Modification sites at PhosphoSitePlus

Other Protein References for ARF5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ARF5 Gene

Domains & Families for ARF5 Gene

Gene Families for ARF5 Gene

Protein Domains for ARF5 Gene

Suggested Antigen Peptide Sequences for ARF5 Gene

Graphical View of Domain Structure for InterPro Entry

P84085

UniProtKB/Swiss-Prot:

ARF5_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARF5: view

Function for ARF5 Gene

Molecular function for ARF5 Gene

GENATLAS Biochemistry:
ADP-ribosylation factor 5,class II,20kDa,low molecular weight GTP binding protein ,a guanine nucleotide dependent protein activator of cholera toxin,Ras superfamily member,involved in vesicular trafficking and activation of phospholipase D,ubiquitously expressed (highly in pancreas,pituitary gland and placenta)
UniProtKB/Swiss-Prot Function:
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

Gene Ontology (GO) - Molecular Function for ARF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 17030804
genes like me logo Genes that share ontologies with ARF5: view
genes like me logo Genes that share phenotypes with ARF5: view

Animal Model Products

miRNA for ARF5 Gene

miRTarBase miRNAs that target ARF5

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARF5 Gene

Localization for ARF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARF5 Gene

Golgi apparatus. Cytoplasm, perinuclear region. Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARF5 Gene COMPARTMENTS Subcellular localization image for ARF5 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
cytosol 3
plasma membrane 3
mitochondrion 2
endosome 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ARF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with ARF5: view

Pathways & Interactions for ARF5 Gene

genes like me logo Genes that share pathways with ARF5: view

Pathways by source for ARF5 Gene

Gene Ontology (GO) - Biological Process for ARF5 Gene

None

No data available for SIGNOR curated interactions for ARF5 Gene

Drugs & Compounds for ARF5 Gene

(1) Drugs for ARF5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARF5: view

Transcripts for ARF5 Gene

Unigene Clusters for ARF5 Gene

ADP-ribosylation factor 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARF5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - -
SP5: -
SP6:
SP7:

Relevant External Links for ARF5 Gene

GeneLoc Exon Structure for
ARF5
ECgene alternative splicing isoforms for
ARF5

Expression for ARF5 Gene

mRNA expression in normal human tissues for ARF5 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARF5 Gene



SOURCE GeneReport for Unigene cluster for ARF5 Gene Hs.653202

genes like me logo Genes that share expression patterns with ARF5: view

Protein tissue co-expression partners for ARF5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARF5 Gene

Orthologs for ARF5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARF5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARF5 35
  • 95.74 (n)
  • 100 (a)
ARF5 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARF5 35
  • 95 (n)
  • 100 (a)
ARF5 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arf5 35
  • 94.26 (n)
  • 100 (a)
Arf5 16
Arf5 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARF5 35
  • 100 (n)
  • 100 (a)
ARF5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arf5 35
  • 94.26 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia ARF5 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARF5 36
  • 92 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii -- 35
zgc:77650 35
  • 76.67 (n)
  • 93.89 (a)
arf5 36
  • 93 (a)
OneToMany
ARF5 (1 of 2) 36
  • 94 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1944 35
fruit fly
(Drosophila melanogaster)
Insecta Arf102F 37
  • 83 (a)
Arf79F 37
  • 80 (a)
Arf102F 36
  • 84 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea arf-1 37
  • 80 (a)
arf-3 37
  • 84 (a)
arl-5 37
  • 44 (a)
arl-6 37
  • 58 (a)
arl-query 37
  • 41 (a)
arf-3 35
  • 71.69 (n)
  • 84.92 (a)
arf-3 36
  • 84 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARF1 36
  • 69 (a)
ManyToMany
ARF2 36
  • 69 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 74 (a)
OneToMany
Species with no ortholog for ARF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARF5 Gene

ENSEMBL:
Gene Tree for ARF5 (if available)
TreeFam:
Gene Tree for ARF5 (if available)

Paralogs for ARF5 Gene

Pseudogenes.org Pseudogenes for ARF5 Gene

genes like me logo Genes that share paralogs with ARF5: view

Variants for ARF5 Gene

Structural Variations from Database of Genomic Variants (DGV) for ARF5 Gene

Variant ID Type Subtype PubMed ID
nsv831122 CNV Gain 17160897

Variation tolerance for ARF5 Gene

Residual Variation Intolerance Score: 37.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARF5 Gene

HapMap Linkage Disequilibrium report
ARF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for ARF5 Gene

Disorders for ARF5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARF5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cholera
  • cholera - vibrio cholerae
- elite association - COSMIC cancer census association via MalaCards
Search ARF5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ARF5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARF5
genes like me logo Genes that share disorders with ARF5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARF5 Gene

Publications for ARF5 Gene

  1. Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells. (PMID: 1993656) Tsuchiya M. … Vaughan M. (J. Biol. Chem. 1991) 2 3 4 67
  2. Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3. (PMID: 11926829) Austin C. … Tooze S.A. (Biochemistry 2002) 3 23
  3. Identification of a new Pyk2 target protein with Arf-GAP activity. (PMID: 10022920) Andreev J. … Schlessinger J. (Mol. Cell. Biol. 1999) 3 23
  4. Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation. (PMID: 10589680) Honda A. … Kanaho Y. (Cell 1999) 3 23
  5. Identification of arfophilin, a target protein for GTP-bound class II ADP-ribosylation factors. (PMID: 10593962) Shin O.H. … Exton J.H. (J. Biol. Chem. 1999) 3 23

Products for ARF5 Gene

Sources for ARF5 Gene

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