External Ids for ARF5 Gene
Previous GeneCards Identifiers for ARF5 Gene
This gene is a member of the human ADP-ribosylation factor (ARF) gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization. [provided by RefSeq, Dec 2010]
GeneCards Summary for ARF5 Gene
ARF5 (ADP Ribosylation Factor 5) is a Protein Coding gene. Diseases associated with ARF5 include Cholera. Among its related pathways are Golgi-to-ER retrograde transport and Transport to the Golgi and subsequent modification. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is ARF4.
UniProtKB/Swiss-Prot for ARF5 Gene
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.