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Aliases for ARF5 Gene

Aliases for ARF5 Gene

  • ADP-Ribosylation Factor 5 2 3

External Ids for ARF5 Gene

Previous GeneCards Identifiers for ARF5 Gene

  • GC07P125706
  • GC07P126771
  • GC07P126782
  • GC07P126822
  • GC07P127015
  • GC07P127228
  • GC07P121589

Summaries for ARF5 Gene

Entrez Gene Summary for ARF5 Gene

  • This gene is a member of the human ADP-ribosylation factor (ARF) gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization. [provided by RefSeq, Dec 2010]

GeneCards Summary for ARF5 Gene

ARF5 (ADP-Ribosylation Factor 5) is a Protein Coding gene. Diseases associated with ARF5 include cholera. Among its related pathways are GPCR Pathway and Class I PI3K signaling events. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is ENSG00000272822.

UniProtKB/Swiss-Prot for ARF5 Gene

  • GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus

Gene Wiki entry for ARF5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARF5 Gene

Genomics for ARF5 Gene

Regulatory Elements for ARF5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARF5 Gene

127,588,345 bp from pter
127,591,705 bp from pter
3,361 bases
Plus strand

Genomic View for ARF5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARF5 Gene

Proteins for ARF5 Gene

  • Protein details for ARF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP-ribosylation factor 5
    Protein Accession:
    Secondary Accessions:
    • P26437

    Protein attributes for ARF5 Gene

    180 amino acids
    Molecular mass:
    20530 Da
    Quaternary structure:
    • Binds ASAP2. Interacts with NCS1/FREQ at the Golgi complex. Interacts with RAB11FIP3 and RAB11FIP4.

    Three dimensional structures from OCA and Proteopedia for ARF5 Gene

neXtProt entry for ARF5 Gene

Proteomics data for ARF5 Gene at MOPED

Post-translational modifications for ARF5 Gene

  • Ubiquitination at Lys142
  • Modification sites at PhosphoSitePlus

Other Protein References for ARF5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARF5 Gene

Domains for ARF5 Gene

Gene Families for ARF5 Gene

  • ARF :ADP-ribosylation factors

Protein Domains for ARF5 Gene

Suggested Antigen Peptide Sequences for ARF5 Gene

Graphical View of Domain Structure for InterPro Entry



  • P84085
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARF5: view

Function for ARF5 Gene

Molecular function for ARF5 Gene

GENATLAS Biochemistry: ADP-ribosylation factor 5,class II,20kDa,low molecular weight GTP binding protein ,a guanine nucleotide dependent protein activator of cholera toxin,Ras superfamily member,involved in vesicular trafficking and activation of phospholipase D,ubiquitously expressed (highly in pancreas,pituitary gland and placenta)
UniProtKB/Swiss-Prot Function: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus

Gene Ontology (GO) - Molecular Function for ARF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 1993656
GO:0004871 signal transducer activity --
GO:0005515 protein binding IPI 17030804
GO:0005525 GTP binding IEA --
GO:0019001 guanyl nucleotide binding --
genes like me logo Genes that share ontologies with ARF5: view

Phenotypes for ARF5 Gene

GenomeRNAi human phenotypes for ARF5:
genes like me logo Genes that share phenotypes with ARF5: view

Animal Model Products

CRISPR Products

miRNA for ARF5 Gene

miRTarBase miRNAs that target ARF5

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARF5 Gene

Localization for ARF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARF5 Gene

Golgi apparatus. Cytoplasm, perinuclear region.

Subcellular locations from

Jensen Localization Image for ARF5 Gene COMPARTMENTS Subcellular localization image for ARF5 gene
Compartment Confidence
golgi apparatus 5
cytosol 3
endosome 2
mitochondrion 2
plasma membrane 2
cytoskeleton 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ARF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with ARF5: view

Pathways for ARF5 Gene

genes like me logo Genes that share pathways with ARF5: view

Pathways by source for ARF5 Gene

2 Qiagen pathways for ARF5 Gene
1 BioSystems pathway for ARF5 Gene

Gene Ontology (GO) - Biological Process for ARF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0008152 metabolic process TAS 1993656
genes like me logo Genes that share ontologies with ARF5: view

Compounds for ARF5 Gene

(1) HMDB Compounds for ARF5 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with ARF5: view

Transcripts for ARF5 Gene

Unigene Clusters for ARF5 Gene

ADP-ribosylation factor 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARF5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARF5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for ARF5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARF5 Gene

mRNA expression in normal human tissues for ARF5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARF5 Gene

SOURCE GeneReport for Unigene cluster for ARF5 Gene Hs.653202

genes like me logo Genes that share expressions with ARF5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARF5 Gene

Orthologs for ARF5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARF5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARF5 35
  • 100 (n)
  • 100 (a)
ARF5 36
  • 100 (a)
(Bos Taurus)
Mammalia ARF5 35
  • 95.74 (n)
  • 100 (a)
ARF5 36
  • 100 (a)
(Canis familiaris)
Mammalia ARF5 35
  • 95 (n)
  • 100 (a)
ARF5 36
  • 100 (a)
(Mus musculus)
Mammalia Arf5 35
  • 94.26 (n)
  • 100 (a)
Arf5 16
Arf5 36
  • 100 (a)
(Monodelphis domestica)
Mammalia ARF5 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia ARF5 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Arf5 35
  • 94.26 (n)
  • 100 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1944 35
(Danio rerio)
Actinopterygii -- 35
arf5 36
  • 93 (a)
ARF5 (1 of 2) 36
  • 94 (a)
zgc:77650 35
  • 76.67 (n)
  • 93.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta Arf102F 36
  • 84 (a)
Arf102F 37
  • 83 (a)
Arf79F 37
  • 80 (a)
(Caenorhabditis elegans)
Secernentea arf-3 35
  • 71.69 (n)
  • 84.92 (a)
arf-3 36
  • 84 (a)
arl-6 37
  • 58 (a)
arf-1 37
  • 80 (a)
arf-3 37
  • 84 (a)
arl-query 37
  • 41 (a)
arl-5 37
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARF1 36
  • 69 (a)
ARF2 36
  • 69 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 74 (a)
Species with no ortholog for ARF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARF5 Gene

Gene Tree for ARF5 (if available)
Gene Tree for ARF5 (if available)

Paralogs for ARF5 Gene Pseudogenes for ARF5 Gene

genes like me logo Genes that share paralogs with ARF5: view

Variants for ARF5 Gene

Sequence variations from dbSNP and Humsavar for ARF5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1419428 -- 127,590,222(+) CCCCC(A/C)ACAGG intron-variant
rs1803150 -- 127,589,131(+) GAAGT(G/T)GGGGG missense, reference
rs2073561 -- 127,587,715(+) AAGCG(C/G)CCAGC upstream-variant-2KB
rs2301566 -- 127,591,334(+) AAGCT(C/G)CTGCG utr-variant-3-prime
rs3190668 -- 127,591,470(+) CTGGA(A/G)CCTTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ARF5 Gene

Variant ID Type Subtype PubMed ID
nsv831122 CNV Gain 17160897

Relevant External Links for ARF5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARF5 Gene

Disorders for ARF5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ARF5 Gene including...

Search for ARF5 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ARF5 Gene

(1) Novoseek inferred disease relationships for ARF5 Gene

Disease -log(P) Hits PubMed IDs
cholera 46.1 1
genes like me logo Genes that share disorders with ARF5: view

No data available for UniProtKB/Swiss-Prot for ARF5 Gene

Publications for ARF5 Gene

  1. Localization and characterization of the human ADP-ribosylation factor 5 (ARF5) gene. (PMID: 9169151) McGuire R.E. … Green E.D. (Genomics 1997) 3 4 23
  2. Identification of a new Pyk2 target protein with Arf-GAP activity. (PMID: 10022920) Andreev J. … Schlessinger J. (Mol. Cell. Biol. 1999) 3 4 23
  3. Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells. (PMID: 1993656) Tsuchiya M. … Vaughan M. (J. Biol. Chem. 1991) 2 3 4
  4. Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1. (PMID: 17030804) Shiba T. … Wakatsuki S. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4
  5. Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation. (PMID: 10589680) Honda A. … Kanaho Y. (Cell 1999) 3 23

Products for ARF5 Gene

  • Addgene plasmids for ARF5

Sources for ARF5 Gene

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