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Aliases for ARF4 Gene

Aliases for ARF4 Gene

  • ADP-Ribosylation Factor 4 2 3
  • ARF2 3 4 6
  • ADP-Ribosylation Factor 2 2 3

External Ids for ARF4 Gene

Previous HGNC Symbols for ARF4 Gene

  • ARF2

Previous GeneCards Identifiers for ARF4 Gene

  • GC03M056428
  • GC03M056911
  • GC03M057411
  • GC03M057514
  • GC03M057507
  • GC03M057532

Summaries for ARF4 Gene

Entrez Gene Summary for ARF4 Gene

  • This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class III; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARF4 Gene

ARF4 (ADP-Ribosylation Factor 4) is a Protein Coding gene. Diseases associated with ARF4 include cholera. Among its related pathways are GPCR Pathway and ErbB1 downstream signaling. GO annotations related to this gene include GTP binding. An important paralog of this gene is ENSG00000272822.

UniProtKB/Swiss-Prot for ARF4 Gene

  • GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus

Gene Wiki entry for ARF4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARF4 Gene

Genomics for ARF4 Gene

Regulatory Elements for ARF4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARF4 Gene

57,571,363 bp from pter
57,598,220 bp from pter
26,858 bases
Minus strand

Genomic View for ARF4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARF4 Gene

Proteins for ARF4 Gene

  • Protein details for ARF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP-ribosylation factor 4
    Protein Accession:
    Secondary Accessions:
    • B2R7J7
    • P21371

    Protein attributes for ARF4 Gene

    180 amino acids
    Molecular mass:
    20511 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ARF4 Gene

neXtProt entry for ARF4 Gene

Proteomics data for ARF4 Gene at MOPED

Post-translational modifications for ARF4 Gene

  • Ubiquitination at Lys142
  • Modification sites at PhosphoSitePlus

Other Protein References for ARF4 Gene

No data available for DME Specific Peptides for ARF4 Gene

Domains for ARF4 Gene

Gene Families for ARF4 Gene

  • ARF :ADP-ribosylation factors

Protein Domains for ARF4 Gene

Suggested Antigen Peptide Sequences for ARF4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P18085
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARF4: view

Function for ARF4 Gene

Molecular function for ARF4 Gene

GENATLAS Biochemistry: ADP ribosylation factor 4,class II,20kDa,low molecular weight GTP binding protein,a guanine nucleotide dependent protein activator of cholera toxin,widely expressed,except in brain,involved in vesicular trafficking and activation of phospholipase D
UniProtKB/Swiss-Prot Function: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus

Gene Ontology (GO) - Molecular Function for ARF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS --
GO:0004871 signal transducer activity --
GO:0005154 epidermal growth factor receptor binding IDA 12446727
GO:0005515 protein binding IPI 17956946
GO:0005525 GTP binding IDA 12446727
genes like me logo Genes that share ontologies with ARF4: view
genes like me logo Genes that share phenotypes with ARF4: view

Animal Model Products

CRISPR Products

miRNA for ARF4 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARF4 Gene

Localization for ARF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARF4 Gene

Golgi apparatus.

Subcellular locations from

Jensen Localization Image for ARF4 Gene COMPARTMENTS Subcellular localization image for ARF4 gene
Compartment Confidence
golgi apparatus 5
cytosol 3
plasma membrane 2
endoplasmic reticulum 1
endosome 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ARF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARF4: view

Pathways for ARF4 Gene

genes like me logo Genes that share pathways with ARF4: view

Pathways by source for ARF4 Gene

2 Qiagen pathways for ARF4 Gene
2 BioSystems pathways for ARF4 Gene

Gene Ontology (GO) - Biological Process for ARF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006471 protein ADP-ribosylation IDA 1899243
GO:0006886 intracellular protein transport --
GO:0006996 organelle organization TAS --
GO:0007173 epidermal growth factor receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway --
genes like me logo Genes that share ontologies with ARF4: view

Compounds for ARF4 Gene

(1) HMDB Compounds for ARF4 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP

(1) Drugbank Compounds for ARF4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
146-91-8 target

(1) Novoseek inferred chemical compound relationships for ARF4 Gene

Compound -log(P) Hits PubMed IDs
guanine 41.8 1
genes like me logo Genes that share compounds with ARF4: view

Transcripts for ARF4 Gene

Unigene Clusters for ARF4 Gene

ADP-ribosylation factor 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARF4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARF4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d
SP1: - - -
SP2: - - -
SP3: - -
SP4: - - - - -
SP5: - - - - - -
SP6: -

Relevant External Links for ARF4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARF4 Gene

mRNA expression in normal human tissues for ARF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARF4 Gene

SOURCE GeneReport for Unigene cluster for ARF4 Gene Hs.652183

genes like me logo Genes that share expressions with ARF4: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARF4 Gene

Orthologs for ARF4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARF4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARF4 35
  • 99.63 (n)
  • 100 (a)
ARF4 36
  • 100 (a)
(Bos Taurus)
Mammalia ARF4 36
  • 97 (a)
(Canis familiaris)
Mammalia ARF4 35
  • 95.37 (n)
  • 96.67 (a)
ARF4 36
  • 97 (a)
(Mus musculus)
Mammalia Arf4 35
  • 92.59 (n)
  • 96.11 (a)
Arf4 16
Arf4 36
  • 96 (a)
(Monodelphis domestica)
Mammalia ARF4 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia ARF4 36
  • 48 (a)
(Rattus norvegicus)
Mammalia Arf4 35
  • 91.48 (n)
  • 96.11 (a)
(Gallus gallus)
Aves ARF4 35
  • 83.84 (n)
  • 93.33 (a)
ARF4 36
  • 96 (a)
(Anolis carolinensis)
Reptilia ARF4 36
  • 97 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398551 35
tropical clawed frog
(Silurana tropicalis)
Amphibia arf4 35
  • 79.26 (n)
  • 95.56 (a)
(Danio rerio)
Actinopterygii ARF4 (2 of 3) 36
  • 69 (a)
ARF4 (3 of 3) 36
  • 70 (a)
arf4a 35
  • 76.85 (n)
  • 90.56 (a)
arf4a 36
  • 76 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002931 35
  • 71.3 (n)
  • 85 (a)
fruit fly
(Drosophila melanogaster)
Insecta Arf102F 35
  • 69.26 (n)
  • 84.44 (a)
Arf102F 36
  • 84 (a)
Arf102F 37
  • 84 (a)
Arf79F 37
  • 82 (a)
(Caenorhabditis elegans)
Secernentea arf-3 36
  • 84 (a)
arl-6 37
  • 58 (a)
arf-1 37
  • 81 (a)
arf-3 37
  • 84 (a)
arl-5 37
  • 46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARF1 36
  • 72 (a)
ARF2 36
  • 71 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 74 (a)
Species with no ortholog for ARF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARF4 Gene

Gene Tree for ARF4 (if available)
Gene Tree for ARF4 (if available)

Paralogs for ARF4 Gene Pseudogenes for ARF4 Gene

genes like me logo Genes that share paralogs with ARF4: view

Variants for ARF4 Gene

Sequence variations from dbSNP and Humsavar for ARF4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
VAR_048317 -

Relevant External Links for ARF4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARF4 Gene

Disorders for ARF4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ARF4 Gene including...

Search for ARF4 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ARF4 Gene

(1) Novoseek inferred disease relationships for ARF4 Gene

Disease -log(P) Hits PubMed IDs
cholera 38.6 1
genes like me logo Genes that share disorders with ARF4: view

No data available for UniProtKB/Swiss-Prot for ARF4 Gene

Publications for ARF4 Gene

  1. Cloning and characterization of the human ADP-ribosylation factor 4 gene. (PMID: 10524252) Lebeda R.A. … Haun R.S. (Gene 1999) 3 4 23
  2. Selective amplification of an mRNA and related pseudogene for a human ADP-ribosylation factor, a guanine nucleotide-dependent protein activator of cholera toxin. (PMID: 2107548) Monaco L. … Vaughan M. (Proc. Natl. Acad. Sci. U.S.A. 1990) 2 3 4
  3. Identification of ADP-ribosylation factor 4 as a suppressor of N-(4-hydroxyphenyl)retinamide-induced cell death. (PMID: 19041174) Woo I.S. … Seo H.G. (Cancer Lett. 2009) 3 23
  4. Human ADP-ribosylation factors. A functionally conserved family of GTP-binding proteins. (PMID: 1899243) Kahn R.A. … Rulka C. (J. Biol. Chem. 1991) 3 4
  5. Human ADP-ribosylation factor 4 (ARF4) gene. Map position 3p14.1. (PMID: 10099884) Kim H.S. (Chromosome Res. 1998) 3 23

Products for ARF4 Gene

  • Addgene plasmids for ARF4

Sources for ARF4 Gene

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