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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ARF4 Gene

protein-coding GIFtS: 61
GCID: GC03M057532

ADP-ribosylation factor 4

(Previous name: ADP-ribosylation factor 2 )
(Previous symbol: ARF2)

Explore 6 diseases affiliated with
ARF4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
ADP-Ribosylation Factor 4¹ ²
ARF2¹ ² ³ ⁵
ADP-Ribosylation Factor 2¹ ²

External Ids:	HGNC: 655¹	Entrez Gene: 378²	Ensembl: ENSG00000168374⁷	OMIM: 601177⁵	UniProtKB: P18085³

Export aliases for ARF4 gene to outside databases

Previous GC identifers: GC03M056428 GC03M056911 GC03M057411 GC03M057514 GC03M057507

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARF4:

This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that

stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as

activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one

family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class III; this gene is a

class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb

and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map

positions at 3p14 or 3p21 have been reported for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ARF4_HUMAN, P18085

Function: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an

ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi

apparatus

Gene Wiki entry for ARF4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ARF4 gene promoter:
MAZR MIF-1 AP-2gamma CREB POU2F1 POU2F1b POU2F1a deltaCREB Pax-4a ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ARF4 promoter sequence

Search SABiosciences Chromatin IP Primers for ARF4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARF4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.2-p21.1 Ensembl cytogenetic band: 3p14.3 HGNC cytogenetic band: 3p21.2-p21.1

ARF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARF4 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M057532: view genomic region (about GC identifiers)

Start:	57,557,090 bp from pter	End:	57,583,947 bp from pter
Size:	26,858 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ARF4_HUMAN, P18085 (See protein sequence)

Recommended Name: ADP-ribosylation factor 4

Size: 180 amino acids; 20511 Da

Subcellular location: Golgi apparatus

Caution: Was originally thought to be ARF2

1 PDB 3D structure from and Proteopedia for ARF4:

1Z6X (3D)

Secondary accessions: B2R7J7 P21371

Explore the universe of human proteins at neXtProt for ARF4: NX_P18085

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P18085

ARF4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001651.1

ENSEMBL proteins:

ENSP00000306010 ENSP00000417501 ENSP00000420655 ENSP00000418360 ENSP00000420254

ENSP00000418388

Human Recombinant Protein Products:

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	Novus Biologicals ARF4 Proteins Novus Biologicals ARF4 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ARF4

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005737	cytoplasm	--	--
GO:0005794	Golgi apparatus	IEA	--
GO:0005886	plasma membrane	IEA	--

ARF4 for ontologies About GeneDecksing

ARF4 Antibody Products:

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	Novus Biologicals ARF4 Antibodies
	Search for Antibodies for ARF4 at Abcam
	Uscn Antibodies for ARF4
	Search ThermoFisher Antibodies for ARF4

Assay Products for ARF4:

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	Uscn ELISAs and CLIAs for ARF4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ARF4 for domains About GeneDecksing

3 InterPro domains/families:

IPR006689 Small_GTPase_ARF/SAR

IPR024156 Small_GTPase_ARF

IPR005225 Small_GTP-bd_dom

Graphical View of Domain Structure for InterPro Entry P18085

ProtoNet protein and cluster: P18085

1 Blocks protein family: IPB006688 ADP-ribosylation factor

UniProtKB/Swiss-Prot: ARF4_HUMAN, P18085

Similarity: Belongs to the small GTPase superfamily. Arf family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ARF4_HUMAN, P18085

Function: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an

ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi

apparatus

Genatlas biochemistry entry for ARF4:

ADP ribosylation factor 4,class II,20kDa,low molecular weight GTP binding protein,a guanine nucleotide dependent

protein activator of cholera toxin,widely expressed,except in brain,involved in vesicular trafficking and activation

of phospholipase D

miRNA Products:		miRTarBase miRNAs that target ARF4: hsa-mir-7 (MIRT004061), hsa-mir-1 (MIRT002823)

		OriGene 3'-UTR Clone: ARF4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARF4
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate ARF4 (see all 16):
		hsa-miR-3673 hsa-miR-148b hsa-miR-196a* hsa-miR-4255 hsa-miR-1271 hsa-miR-3065-5p hsa-miR-222 hsa-miR-221

		SwitchGear 3'UTR luciferase reporter plasmid: ARF4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARF4 (see all 7) OriGene shRNA RFP: ARF4 OriGene siRNA: ARF4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARF4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ARF4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARF4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARF4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ARF4 (NM_001660)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARF4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARF4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ARF4
		Search LifeMap BioReagents cell lines for ARF4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARF4

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	TAS	2107548
GO:0005515	protein binding	IPI	--
GO:0005525	GTP binding	IEA	--

ARF4 for ontologies About GeneDecksing

6 GenomeRNAi human phenotypes for ARF4:

Decreased viability	G0/1 arrest	Increased G1 DNA content	Increased cilium length after
Proliferating cells	Synthetic lethal with Ras

Animal Models:
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Arf4):

behavior/neurological

mortality/aging

nervous system

ARF4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

EGFR1 Signaling Pathway

EGFR1 Signaling Pathway

1.00

ErbB1 downstream signaling

ErbB1 downstream signaling

1.00

GPCR Pathway

Paxillin Interactions

0.53

Neuropathic Pain-Signaling in Dorsal Horn Neurons

Cholera Infection

0.40

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ARF4

	Cholera Infection
	Paxillin Interactions

2 BioSystems Pathways for ARF4

	EGFR1 Signaling Pathway
	ErbB1 downstream signaling

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ARF4

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/567 Interacting proteins for ARF4 (P18085^{1, 2, 3} ENSP00000306010⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 567)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BABAM1	Q9NWV8²^,³, ENSP00000352408⁴	MINT-7945693 I2D: score=2 STRING: ENSP00000352408
MYC	P01106³, ENSP00000367207⁴	I2D: score=3 STRING: ENSP00000367207
EGFR	P00533³, ENSP00000275493⁴	I2D: score=2 STRING: ENSP00000275493
RAB11FIP3	O75154³, ENSP00000262305⁴	I2D: score=1 STRING: ENSP00000262305
AGO4	Q9HCK5³, ENSP00000362306⁴	I2D: score=2 STRING: ENSP00000362306

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006184	GTP catabolic process	TAS	2107548
GO:0007173	epidermal growth factor receptor signaling pathway	IEA	--
GO:0007264	small GTPase mediated signal transduction	IEA	--
GO:0007420	brain development	IEA	--
GO:0015031	protein transport	IEA	--

ARF4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ARF4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ARF4

1 HMDB Compound for ARF4 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

1 DrugBank Compound for ARF4 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Guanosine-5'-Diphosphate	--	146-91-8	target	--	--

1 Novoseek chemical compound relationship for ARF4 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
guanine	41.8	2	10524252 (1)

Search CenterWatch for drugs/clinical trials and news about ARF4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ARF4 gene:

NM_001660.3

Unigene Cluster for ARF4:

ADP-ribosylation factor 4

Hs.652183 [show with all ESTs]

Unigene Representative Sequence: NM_001660

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000303436(uc003dix.4) ENST00000496292 ENST00000489843 ENST00000486310

ENST00000483848 ENST00000463880 ENST00000493378 ENST00000495354 ENST00000488156

miRNA Products:		OriGene 3'-UTR Clone: ARF4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARF4
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate ARF4 (see all 16):
		hsa-miR-3673 hsa-miR-148b hsa-miR-196a* hsa-miR-4255 hsa-miR-1271 hsa-miR-3065-5p hsa-miR-222 hsa-miR-221

		SwitchGear 3'UTR luciferase reporter plasmid: ARF4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARF4 (see all 7) OriGene shRNA RFP: ARF4 OriGene siRNA: ARF4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARF4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARF4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARF4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ARF4 (NM_001660)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARF4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARF4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARF4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ARF4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARF4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARF4

Additional cDNA sequence:

AF493883.1 AK313008.1 BC003364.1 BC008753.2 BC016325.1 BC022866.1 M36341.1

24/32 DOTS entries (see all 32):

DT.120191 DT.92465044 DT.95278541 DT.92389272 DT.100883817 DT.92039146 DT.100678387 DT.100883824

DT.120912848 DT.100883821 DT.120912819 DT.120912851 DT.100032418 DT.100039128 DT.92465093 DT.100883809

DT.100883810 DT.100883812 DT.121494332 DT.92465055 DT.95278540 DT.120912903 DT.120912924 DT.75180471

24/1234 AceView cDNA sequences (see all 1234):

BF796219 BQ000520 CF264737 CA843151 BM798623 F07586 BM452931 AA133313

BU677927 AL702754 AL535829 AL540831 CA449203 BM852063 BM478031 BQ723666

BE858114 BU154854 W24929 N44515 AA652372 BM831771 CB106053 AA983614

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ARF4 (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	^	3	^	4	^	5a	·	5b	·	5c	·	5d	^	6	^	7a	·	7b	^	8a	·	8b	·	8c	·	8d
SP1:															-				-		-
SP2:															-				-		-
SP3:															-				-
SP4:															-				-		-		-		-
SP5:															-		-		-		-		-		-

ECgene alternative splicing isoforms for ARF4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ARF4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGCTTTTGT

About this image

ARF4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/16 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 16)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Foregut

Foregut Endoderm Cells

Endoderm

Neural Tube

Spinal Neural Tube Cells

Neural Ectoderm

Neural Ectoderm

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Bone

Mandibular Process

Bone

Rostral Skull Membranous Bones

Bone

Bone

Brain

Cartilage

Thoracic Intervertebral Disc

Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ARF4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARF4

SOURCE GeneReport for Unigene cluster: Hs.652183

SABiosciences Custom PCR Arrays for ARF4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARF4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ARF4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARF4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARF4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARF4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ARF4 gene from 6/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ARF4¹	ADP-ribosylation factor 4	85.95(n) 96.23(a)		769725 XM_001232783.2 XP_001232784.2
lizard (Anolis carolinensis)	Reptilia	ARF4⁶	--	97(a)	1 ↔ 1	2(163350120-163366597)
African clawed frog (Xenopus laevis)	Amphibia	LOC398551²	hypothetical protein LOC398551	82.62(n)		BC054189.1
zebrafish (Danio rerio)	Actinopterygii	arf4a¹	ADP-ribosylation factor 4a	76.85(n) 90.56(a)		445196 NM_001003590.1 NP_001003590.1
fruit fly (Drosophila melanogaster)	Insecta	Arf102F³	protein amino acid ADP-ribosylation GTP binding	84(a) (best of 2)		4 102D4 --
worm (Caenorhabditis elegans)	Secernentea	arf-3³	GTP-binding protein	84(a) (best of 4)		IV(7982620-7983731) --

ENSEMBL Gene Tree for ARF4 (if available)
TreeFam Gene Tree for ARF4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ARF4 gene

ARL4A² ARL11² ARF5² ARF1² ARL4D² ARF3² ARL14² ARL9²

ARF6² ARL17B² ARL4C² TRIM23² ARL10²

18/32 SIMAP similar genes for ARF4 using alignment to 6 protein entries: ARF4_HUMAN (see all proteins) (see all similar genes):

ARF5 ARF1 ARF3 ARF6 ARL4A ARL17A

ARL17B ARL1 ARL14 ARL3 ARL5B ARL2

ARL6 ARL5A RAB8B ARL11 ARL4C ARL7

ARF4 for paralogs About GeneDecksing

4 Pseudogenes.org Pseudogenes for ARF4
PGOHUM00000239815 PGOHUM00000248487 PGOHUM00000247573 PGOHUM00000236786

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186765927^1,2		--	57556709(+)	`ATTTTG/TTTGTT`	1	--	ds500¹		0	--	--	--	--
rs9311654^1,2	C,H,	--	57556829(+)	`CCTCCC/TAAAGT`	1	--	ds500¹		11		NA WA CSA EA	371
rs145040262^1,2		--	57556961(+)	`TCCACC/TTTATA`	1	--	ds500¹		0	--	--	--	--
rs192350436^1,2		--	57556983(+)	`CTACCA/CGTGGG`	1	--	ds500¹		0	--	--	--	--
rs138880502^1,2		--	57557079(+)	`AAAAGA/CACACA`	1	--	ds500¹		0	--	--	--	--
rs141406289^1,2		--	57557085(+)	`ACACAC/TACAAT`	1	--	ds500¹		0	--	--	--	--
rs6908^1,2	C,F,	--	57557124(-)	`CCATTT/CGGAAT`	1	--	ut3¹		3		NA WA	6
rs6907^1,2	C,F,	--	57557134(-)	`TCTTCA/TTAACC`	1	--	ut3¹ ese³		4		NA WA	8
rs6906^1,2	C,F,	--	57557160(-)	`ACTCAT/CCAAAT`	1	--	ut3¹		7		MN NA WA	430
rs183962464^1,2		--	57557230(+)	`TCATAC/TACTGA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ARF4 (57557090 - 57583947 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ARF4: --
Human Gene Mutation Database (HGMD): ARF4

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ARF4 for disorders           About GeneDecksing

OMIM gene information: 601177    OMIM disorders: --

6 diseases for ARF4:    About MalaCards

cholera retinal disease retinitis gastric cancer

breast cancer malaria

1 disease from the University of Copenhagen DISEASES database for ARF4:

Cholera

1 Novoseek disease relationship for ARF4 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cholera	38.6	2	10524252 (1)

Export disorders for ARF4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ARF4 gene, integrated from 9 sources (see all 48):
(articles sorted by number of sources associating them with ARF4)

Utopia: connect your pdf to the dynamic
world of online information

Selective amplification of an mRNA and related pseudogene for a human ADP-ribosylation factor, a guanine nucleotide-dependent protein activator of cholera toxin. (PubMed id 2107548)^{1, 2, 3} Monaco L....Vaughan M. (1990)
Cloning and characterization of the human ADP-ribosylation factor 4 gene. (PubMed id 10524252)^{1, 2, 9} Lebeda R.A. and Haun R.S. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Human ADP-ribosylation factors. A functionally conserved family of GTP-binding proteins. (PubMed id 1899243)^{1, 2} Kahn R.A.... Rulka C. (1991)
Identification of ADP-ribosylation factor 4 as a suppressor of N-(4-hydroxyphenyl)retinamide-induced cell death. (PubMed id 19041174)^{1, 9} Woo I.S....Seo H.G. (2009)
Human ADP-ribosylation factor 4 (ARF4) gene. Map position 3p14.1. (PubMed id 10099884)^{1, 9} Kim H.S. (1998)
Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)¹ Wu Z....Ma L. (2012)
Shotgun proteomics and network analysis of ubiquitin-r elated proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)¹ Zhou J....Liang S. (2012)
Class II ADP-ribosylation factors are required for eff icient secretion of dengue viruses. (PubMed id 22105072)¹ Kudelko M....Wang P.G. (2012)
Regulation of ADP-ribosylation factor 4 expression by small leucine zipper protein and involvement in breast cancer cell migration. (PubMed id 22004728)¹ Jang S.Y....Ko J. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 378	HGNC: 655	AceView: ARF4	Ensembl:ENSG00000168374	euGenes: HUgn378
ECgene: ARF4	H-InvDB: ARF4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ARF4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ARF4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ARF4 gene:
Search GeneIP for patents involving ARF4

GeneCards and IP:
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