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ARF4 Gene

protein-coding   GIFtS: 64
GCID: GC03M057559

ADP-Ribosylation Factor 4

(Previous name: ADP-ribosylation factor 2)
(Previous symbol: ARF2)
  See ARF4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADP-Ribosylation Factor 41 2
ARF21 2 3 5
ADP-Ribosylation Factor 21 2

External Ids:    HGNC: 6551   Entrez Gene: 3782   Ensembl: ENSG000001683747   OMIM: 6011775   UniProtKB: P180853   

Export aliases for ARF4 gene to outside databases

Previous GC identifers: GC03M056428 GC03M056911 GC03M057411 GC03M057514 GC03M057507 GC03M057532


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARF4 Gene:
This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins
that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and
as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and
constitute one family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class
III; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene
spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the
human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene. (provided by RefSeq, Jul
2008)

GeneCards Summary for ARF4 Gene:
ARF4 (ADP-ribosylation factor 4) is a protein-coding gene. Diseases associated with ARF4 include cholera. GO annotations related to this gene include GTP binding. An important paralog of this gene is ARL2.

UniProtKB/Swiss-Prot: ARF4_HUMAN, P18085
Function: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an
ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the
Golgi apparatus

Gene Wiki entry for ARF4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARF4 gene promoter:
         MAZR   MIF-1   AP-2gamma   CREB   POU2F1   POU2F1b   POU2F1a   deltaCREB   Pax-4a   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARF4 promoter sequence
   Search Chromatin IP Primers for ARF4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.2-p21.1   Ensembl cytogenetic band:  3p14.3   HGNC cytogenetic band: 3p21.2-p21.1

ARF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARF4 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M057559:  view genomic region     (about GC identifiers)

Start:
57,557,090 bp from pter      End:
57,583,947 bp from pter
Size:
26,858 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ARF4_HUMAN, P18085 (See protein sequence)
Recommended Name: ADP-ribosylation factor 4  
Size: 180 amino acids; 20511 Da
Caution: Was originally thought to be ARF2
1 PDB 3D structure from and Proteopedia for ARF4:
1Z6X (3D)    
Secondary accessions: B2R7J7 P21371

Explore the universe of human proteins at neXtProt for ARF4: NX_P18085

Explore proteomics data for ARF4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys142
  • Modification sites at PhosphoSitePlus

  • See ARF4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001651.1  
    ENSEMBL proteins: 
     ENSP00000306010   ENSP00000417501   ENSP00000475828   ENSP00000420655   ENSP00000420254  
     ENSP00000418388  

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    antibodies-online proteins for ARF4 (18 products) 

     
    antibodies-online peptides for ARF4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARF: ADP-ribosylation factors

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR027417 P-loop_NTPase
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF

    Graphical View of Domain Structure for InterPro Entry P18085

    ProtoNet protein and cluster: P18085

    1 Blocks protein domain: IPB006688 ADP-ribosylation factor

    UniProtKB/Swiss-Prot: ARF4_HUMAN, P18085
    Similarity: Belongs to the small GTPase superfamily. Arf family


    Find genes that share domains with ARF4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARF4_HUMAN, P18085
    Function: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an
    ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the
    Golgi apparatus

         Genatlas biochemistry entry for ARF4:
    ADP ribosylation factor 4,class II,20kDa,low molecular weight GTP binding protein,a guanine nucleotide dependent
    protein activator of cholera toxin,widely expressed,except in brain,involved in vesicular trafficking and
    activation of phospholipase D

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0004871signal transducer activity ----
    GO:0005154epidermal growth factor receptor binding IDA12446727
    GO:0005515protein binding IPI--
    GO:0005525GTP binding IDA12446727
         
    Find genes that share ontologies with ARF4           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for ARF4:
     Decreased viability  G0/1 arrest  Increased G1 DNA content  Increased cilium length after  
     Proliferating cells  Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Arf4):
     behavior/neurological  mortality/aging  nervous system 

    Find genes that share phenotypes with ARF4           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ARF4

    miRNA
    Products:
        
    miRTarBase miRNAs that target ARF4:
    hsa-mir-361-5p (MIRT020084), hsa-mir-142-3p (MIRT021610), hsa-mir-7-5p (MIRT004061), hsa-mir-1 (MIRT002823)

    Block miRNA regulation of human, mouse, rat ARF4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARF4 (see all 16):
    hsa-miR-3673 hsa-miR-148b hsa-miR-196a* hsa-miR-4255 hsa-miR-1271 hsa-miR-3065-5p hsa-miR-222 hsa-miR-221
    SwitchGear 3'UTR luciferase reporter plasmidARF4 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for ARF4 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARF4_HUMAN, P18085: Golgi apparatus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol3
    plasma membrane2
    endoplasmic reticulum1
    endosome1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus IEA--
    GO:0005829cytosol IDA12446727

    Find genes that share ontologies with ARF4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARF4 About    
    See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Paxillin Interactions0.73
    2Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Cholera Infection0.40
    3ErbB1 downstream signaling
    ErbB1 downstream signaling
    4EGFR1 Signaling Pathway
    EGFR1 Signaling Pathway

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ARF4
        Cholera Infection
    Paxillin Interactions

    2 BioSystems Pathways for ARF4
        EGFR1 Signaling Pathway
    ErbB1 downstream signaling



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARF4
    Interactions:

        GeneGlobe Interaction Network for ARF4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARF4 (P180851, 2, 3 ENSP000003060104) via UniProtKB, MINT, STRING, and/or I2D (see all 677)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BABAM1Q9NWV82, 3, ENSP000003524084MINT-7945693 I2D: score=2 STRING: ENSP00000352408
    AGO4Q9HCK53, ENSP000003623064I2D: score=2 STRING: ENSP00000362306
    CADPS2Q86UW73, ENSP000004004014I2D: score=1 STRING: ENSP00000400401
    EGFRP005333, ENSP000002754934I2D: score=2 STRING: ENSP00000275493
    RAB11FIP3O751543, ENSP000002623054I2D: score=1 STRING: ENSP00000262305
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006471protein ADP-ribosylation IDA1899243
    GO:0006886intracellular protein transport ----
    GO:0007173epidermal growth factor receptor signaling pathway IEA--
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007264small GTPase mediated signal transduction IEA--

    Find genes that share ontologies with ARF4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARF4

    1 HMDB Compound for ARF4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 DrugBank Compound for ARF4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Guanosine-5'-Diphosphate-- 146-91-8target----

    1 Novoseek inferred chemical compound relationship for ARF4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    guanine 41.8 2 10524252 (1)



    Find genes that share compounds with ARF4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARF4 gene: 
    NM_001660.3  

    Unigene Cluster for ARF4:

    ADP-ribosylation factor 4
    Hs.652183  [show with all ESTs]
    Unigene Representative Sequence: NM_001660
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303436(uc003dix.4) ENST00000496292 ENST00000489843 ENST00000486310
    ENST00000483848 ENST00000463880 ENST00000493378 ENST00000495354 ENST00000488156

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ARF4 (see all 16):
    hsa-miR-3673 hsa-miR-148b hsa-miR-196a* hsa-miR-4255 hsa-miR-1271 hsa-miR-3065-5p hsa-miR-222 hsa-miR-221
    SwitchGear 3'UTR luciferase reporter plasmidARF4 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat ARF4

    Additional mRNA sequence: 

    AF493883.1 AK313008.1 BC003364.1 BC008753.2 BC016325.1 BC022866.1 M36341.1 

    Selected DOTS entries (see all 31):

    DT.120191  DT.92465044  DT.95278541  DT.92389272  DT.100883817  DT.92039146  DT.100883824  DT.100678387 
    DT.120912819  DT.120912848  DT.100883821  DT.120912851  DT.100032418  DT.92465093  DT.100883809  DT.100883810 
    DT.100883812  DT.92465055  DT.100039128  DT.120912903  DT.120912924  DT.121494332  DT.92377942  DT.100681297 

    Selected AceView cDNA sequences (see all 1234):

    CA447124 BE858119 AU119774 BQ000328 N44515 CA447386 CR596585 BM852016 
    CR591617 AL555133 BU155240 BU679960 AL535302 BM971647 BC008753 AA368974 
    W67723 AI754164 CR607207 BU521003 BQ437927 AA043350 BM763285 BF477390 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARF4 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d
    SP1:                                            -           -     -                                                         
    SP2:                                            -           -     -                                                         
    SP3:                                            -           -                                                               
    SP4:                                            -           -     -     -     -                                             
    SP5:                                            -     -     -     -     -     -                                             


    ECgene alternative splicing isoforms for ARF4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARF4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGCTTTTGT
    ARF4 Expression
    About this image


    ARF4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Floor Plate Cells Spinal Floor Plate
             Metencephalon
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Stylopod Long Bone
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Intervertebral Disc
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    ARF4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARF4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.652183
        Custom PCR Arrays for ARF4
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    QuantiFast Probe-based Assays in human, mouse, rat ARF4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARF4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARF4 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arf41 , 5 ADP-ribosylation factor 41, 5 92.59(n)1
    96.11(a)1
      14 (16.09 cM)5
    118431  NM_007479.31  NP_031505.11 
     266380745 
    chicken
    (Gallus gallus)
    Aves ARF41 ADP-ribosylation factor 4 83.84(n)
    93.33(a)
      769725  XM_001232783.3  XP_001232784.3 
    lizard
    (Anolis carolinensis)
    Reptilia ARF46
    ADP-ribosylation factor 4
    97(a)
    1 ↔ 1
    2(163347730-163366597)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985512 hypothetical protein LOC398551 82.62(n)    BC054189.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arf4a1 ADP-ribosylation factor 4a 76.85(n)
    90.56(a)
      445196  NM_001003590.1  NP_001003590.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Arf102F1 , 3 protein amino acid ADP-ribosylation GTP
    binding3
    ADP ribosylation factor 102F1
    84(a)
    (best of 2)3
    69.26(n)1
    84.44(a)1
      4 102D43
    438231  NM_079892.31  NP_524631.11 
    worm
    (Caenorhabditis elegans)
    Secernentea arf-33 GTP-binding protein 84(a)
    (best of 4)
      IV(7982620-7983731)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARF16
    ARF26
    ADP-ribosylation factor, GTPase of the Ras superfa...
    ADP-ribosylation factor, GTPase of the Ras superfa...
    72(a)
    71(a)
    many ↔ many
    many ↔ many
    IV(116321-116866) YDL192W
    IV(216529-217074) YDL137W


    ENSEMBL Gene Tree for ARF4 (if available)
    TreeFam Gene Tree for ARF4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARF4 gene
    ARL22  ARL5B2  ENSG000002730032  ARL5C2  ENSG000002728222  ARF52  ARF12  ARL32  
    ARL5A2  ARF32  ARF62  TRIM232  
    Selected SIMAP similar genes for ARF4 using alignment to 6 protein entries:     ARF4_HUMAN (see all proteins) (see all similar genes):
    ARF5    ARF1    ARF3    ARF6    ARL4A    ARL17B
    ARL1    ARL2    ARL17A    ARL14    ARL3    ARL5B
    ARL6    ARL5A    RAB8B    ARL11    ARL4C    ARL7

    Find genes that share paralogs with ARF4           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for ARF4
    PGOHUM00000239815 PGOHUM00000248487 PGOHUM00000247573 PGOHUM00000236786


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARF4 (see all 537)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1867659271,2
    C--57556709(+) ATTTTG/TTTGTT 1 -- ds50010--------
    rs93116541,2
    C,H--57556829(+) CCTCCC/TAAAGT 1 -- ds500111Minor allele frequency- T:0.23NA WA CSA EA 371
    rs1450402621,2
    --57556961(+) TCCACC/TTTATA 1 -- ds50010--------
    rs1923504361,2
    --57556983(+) CTACCA/CGTGGG 1 -- ds50010--------
    rs1388805021,2
    --57557079(+) AAAAGA/CACACA 1 -- ds50010--------
    rs1414062891,2
    C--57557085(+) ACACAC/TACAAT 1 -- ds50010--------
    rs69081,2
    C,F--57557124(-) CCATTT/CGGAAT 1 -- ut313Minor allele frequency- C:0.33NA WA 6
    rs69071,2
    C,F--57557134(-) TCTTCA/TTAACC 1 -- ut31 ese34Minor allele frequency- T:0.38NA WA 8
    rs69061,2
    C,F--57557160(-) ACTCAT/CCAAAT 1 -- ut317Minor allele frequency- C:0.27MN NA WA 430
    rs1839624641,2
    --57557230(+) TCATAC/TACTGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ARF4 (57557090 - 57583947 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ARF4: --
    Human Gene Mutation Database (HGMD): ARF4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARF4
    DNA2.0 Custom Variant and Variant Library Synthesis for ARF4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601177    OMIM disorders: --

    1 disease for ARF4:    
    About MalaCards
    cholera

    1 disease from the University of Copenhagen DISEASES database for ARF4:
    Cholera

    Find genes that share disorders with ARF4           About GenesLikeMe

    1 Novoseek inferred disease relationship for ARF4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholera 38.6 2 10524252 (1)


    Export disorders for ARF4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARF4 gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with ARF4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Selective amplification of an mRNA and related pseudogene for a human ADP-ribosylation factor, a guanine nucleotide-dependent protein activator of cholera toxin. (PubMed id 2107548)1, 2, 3 Monaco L....Vaughan M. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    2. Cloning and characterization of the human ADP-ribosylation factor 4 gene. (PubMed id 10524252)1, 2, 9 Lebeda R.A. and Haun R.S. (Gene 1999)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Human ADP-ribosylation factors. A functionally conserved family of GTP-binding proteins. (PubMed id 1899243)1, 2 Kahn R.A.... Rulka C. (J. Biol. Chem. 1991)
    5. Identification of ADP-ribosylation factor 4 as a suppressor of N-(4-hydroxyphenyl)retinamide-induced cell death. (PubMed id 19041174)1, 9 Woo I.S....Seo H.G. (Cancer Lett. 2009)
    6. Human ADP-ribosylation factor 4 (ARF4) gene. Map position 3p14.1. (PubMed id 10099884)1, 9 Kim H.S. (Chromosome Res. 1998)
    7. Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. (PubMed id 23464991)1 Scifo E....Lalowski M. (J. Proteome Res. 2013)
    8. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens. (PubMed id 24185178)1 Reiling J.H....Sabatini D.M. (Nat. Cell Biol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 378 HGNC: 655 AceView: ARF4 Ensembl:ENSG00000168374 euGenes: HUgn378
    ECgene: ARF4 H-InvDB: ARF4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ARF4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARF4 gene:
    Search GeneIP for patents involving ARF4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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