External Ids for ARF3 Gene
Previous GeneCards Identifiers for ARF3 Gene
ADP-ribosylation factor 3 (ARF3) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6) and members of each class share a common gene organization. The ARF3 gene contains five exons and four introns. [provided by RefSeq, Jul 2008]
GeneCards Summary for ARF3 Gene
ARF3 (ADP Ribosylation Factor 3) is a Protein Coding gene. Diseases associated with ARF3 include Cholera and Distal Hereditary Motor Neuropathy, Type Ii. Among its related pathways are Golgi-to-ER retrograde transport and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is ENSG00000272822.
UniProtKB/Swiss-Prot for ARF3 Gene
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.