Aliases for ARF3 Gene
External Ids for ARF3 Gene
- HGNC: 654
- Entrez Gene: 377
- Ensembl: ENSG00000134287
- OMIM: 103190
- UniProtKB: P61204
Previous GeneCards Identifiers for ARF3 Gene
- GC12M049256
- GC12M049556
- GC12M049046
- GC12M047616
- GC12M049329
- GC12M046361
- GC12M049299
Summaries for ARF3 Gene
-
ADP-ribosylation factor 3 (ARF3) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6) and members of each class share a common gene organization. The ARF3 gene contains five exons and four introns. [provided by RefSeq, Jul 2008]
GeneCards Summary for ARF3 Gene
ARF3 (ADP Ribosylation Factor 3) is a Protein Coding gene. Diseases associated with ARF3 include Cholera and Distal Hereditary Motor Neuropathy, Type Ii. Among its related pathways are Vesicle-mediated transport and Transport to the Golgi and subsequent modification. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is ARF1.
UniProtKB/Swiss-Prot for ARF3 Gene
-
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARF3 Gene
Genomics for ARF3 Gene
Regulatory Elements for ARF3 Gene
- Transcription factor binding sites by QIAGEN in the ARF3 gene promoter:
Regulatory Element Products
Genomic Location for ARF3 Gene
- Chromosome:
- 12
- Start:
- 48,931,156 bp from pter
- End:
- 48,957,551 bp from pter
- Size:
- 26,396 bases
- Orientation:
- Minus strand
Genomic View for ARF3 Gene
- Cytogenetic band:
-
- 12q13.12 by Ensembl
- 12q13.12 by Entrez Gene
- 12q13.12 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ARF3 Gene
Proteins for ARF3 Gene
-
Protein details for ARF3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P61204-ARF3_HUMAN
- Recommended name:
- ADP-ribosylation factor 3
- Protein Accession:
- P61204
- A8K6G8
- B7ZB63
- P16587
Protein attributes for ARF3 Gene
- Size:
- 181 amino acids
- Molecular mass:
- 20601 Da
- Quaternary structure:
-
- Interacts with PRKCABP. Interacts with PI4KB and NCS1/FREQ at the Golgi complex.
Protein Expression for ARF3 Gene
Post-translational modifications for ARF3 Gene
Other Protein References for ARF3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
Abcam antibodies for ARF3
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- antibodies-online Antibodies for ARF3: See all 27
- GeneTex ARF3 antibody for ARF3
-
Santa Cruz Biotechnology (SCBT) Antibodies for ARF3
Protein Products
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- ProSpec Recombinant Proteins for ARF3
- antibodies-online Proteins for ARF3: See all 16
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- Search GeneTex for Proteins for ARF3
-
Abcam proteins for ARF3
Assay Products
- antibodies-online Kits for ARF3: See all 4
No data available for DME Specific Peptides for ARF3 Gene
Domains & Families for ARF3 Gene
Gene Families for ARF3 Gene
- HGNC:
Protein Domains for ARF3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ARF3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P61204- Family:
-
- Belongs to the small GTPase superfamily. Arf family.
Function for ARF3 Gene
Molecular function for ARF3 Gene
- GENATLAS Biochemistry:
- ADP ribosylation factor 3,class I,low molecular weight GTP binding protein,a guanine nucleotide dependent protein activator of cholera toxin,with two transcripts resulting from alternative use of polyadenylation transcripts,(20kDa),widely expressed,especially in brain,Ras superfamily member,involved in vesicular trafficking and activation of phospholipase D
- UniProtKB/Swiss-Prot Function:
- GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003924 | GTPase activity | TAS | 1744102 |
| GO:0005525 | GTP binding | IEA | -- |
Phenotypes for ARF3 Gene
- MGI mutant phenotypes for ARF3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ARF3:
Animal Models for ARF3 Gene
- MGI Knock Outs for ARF3:
-
- Arf3 tm1b(EUCOMM)Hmgu
Animal Model Products
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-
-
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CRISPR Products
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miRNA for ARF3 Gene
- miRTarBase miRNAs that target ARF3
-
- hsa-mir-1-3p (MIRT002742)
- hsa-mir-320a (MIRT044395)
- hsa-mir-125b-5p (MIRT045938)
- hsa-mir-10a-5p (MIRT047633)
- hsa-mir-30c-5p (MIRT047965)
- hsa-mir-6834-5p (MIRT485833)
- hsa-mir-6133 (MIRT485834)
- hsa-mir-6130 (MIRT485835)
- hsa-mir-6129 (MIRT485836)
- hsa-mir-6127 (MIRT485837)
- hsa-mir-4510 (MIRT485838)
- hsa-mir-4419a (MIRT485839)
- hsa-mir-6875-5p (MIRT485840)
- hsa-mir-3126-5p (MIRT485841)
- hsa-mir-34c-3p (MIRT485842)
- hsa-mir-6760-5p (MIRT485843)
- hsa-mir-5195-5p (MIRT485844)
- hsa-mir-582-3p (MIRT485845)
- hsa-mir-183-5p (MIRT485846)
- hsa-mir-377-3p (MIRT541477)
- hsa-mir-3941 (MIRT541478)
- hsa-mir-342-3p (MIRT541479)
- hsa-mir-4650-5p (MIRT541480)
- hsa-mir-6768-5p (MIRT541481)
- hsa-mir-603 (MIRT541482)
- hsa-mir-362-3p (MIRT541483)
- hsa-mir-329-3p (MIRT541484)
- hsa-mir-8485 (MIRT541485)
- hsa-mir-4789-5p (MIRT542403)
- hsa-mir-4477a (MIRT545532)
- hsa-mir-4424 (MIRT545533)
- hsa-mir-6770-5p (MIRT545534)
- hsa-mir-3976 (MIRT545535)
- hsa-mir-3123 (MIRT545536)
- hsa-mir-3925-5p (MIRT545537)
miRNA Products
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-
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- Mammalian expression: PiggyBac
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- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
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Horizon Cell Lines for ARF3
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARF3 Gene
Localization for ARF3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ARF3 Gene
- Golgi apparatus. Cytoplasm, perinuclear region.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005622 | intracellular | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0048471 | perinuclear region of cytoplasm | IEA | -- |
Pathways & Interactions for ARF3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transport to the Golgi and subsequent modification | ||
| 2 | Golgi-to-ER retrograde transport | ||
| 3 | Vesicle-mediated transport | ||
| 4 | Metabolism |
.37
|
|
| 5 | Metabolism of proteins | ||
Pathways by source for ARF3 Gene
16 Reactome pathways for ARF3 Gene
1 KEGG pathway for ARF3 Gene
2 Qiagen pathways for ARF3 Gene
Interacting Proteins for ARF3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006661 | phosphatidylinositol biosynthetic process | TAS | -- |
| GO:0006810 | transport | IEA | -- |
| GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER | IGI | 24768165 |
| GO:0007264 | small GTPase mediated signal transduction | IEA | -- |
| GO:0015031 | protein transport | IEA | -- |
No data available for SIGNOR curated interactions for ARF3 Gene
Drugs & Compounds for ARF3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Guanosine triphosphate | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for ARF3 Gene
mRNA/cDNA for ARF3 Gene
- (10) Selected AceView cDNA sequences:
- (13) Additional mRNA sequences :
- (3) REFSEQ mRNAs :
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ARF3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ARF3
-
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miRNA Products
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Inhibitory RNA Products
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-
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | · | 4f | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - |
Expression for ARF3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Lung (Respiratory System)
- Kidney (Urinary System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARF3 Gene
NURSA nuclear receptor signaling pathways regulating expression of ARF3 Gene:
ARF3SOURCE GeneReport for Unigene cluster for ARF3 Gene:
Hs.119177Evidence on tissue expression from TISSUES for ARF3 Gene
- Nervous system(5)
- Skin(4.8)
- Lung(4.7)
- Kidney(3.5)
- Intestine(3.1)
- Pancreas(3)
- Eye(2.8)
- Heart(2.8)
- Stomach(2.8)
- Liver(2.7)
- Muscle(2.7)
- Adrenal gland(2.3)
- Blood(2.3)
Primer Products
-
OriGene qPCR primer pairs for ARF3
-
OriGene qPCR primer pairs and template standards for ARF3
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARF3 Gene
Orthologs for ARF3 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | ARF1 35 |
|
OneToOne | |
| ARF3 34 |
|
||||
| chimpanzee (Pan troglodytes) |
Mammalia | ARF3 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ARF3 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Arf3 16 35 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Arf3 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ARF3 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | arf3 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.6539 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | arf3b 35 |
|
OneToOne | |
| arf3a 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Arf79F 36 35 |
|
||
| Arf102F 36 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | arf-1 36 |
|
|
|
| arf-1.2 35 |
|
OneToMany | |||
| arf-3 36 |
|
|
|||
| arl-6 36 |
|
|
|||
| arl-5 36 |
|
|
|||
| arl-query 36 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ARF1 35 |
|
ManyToMany | |
| ARF2 35 |
|
ManyToMany | |||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | ARFA1E 34 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.11398 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os07g0223400 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
ManyToMany |
- Species where no ortholog for ARF3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ARF3 Gene
Paralogs for ARF3 Gene
(33) SIMAP similar genes for ARF3 Gene using alignment to 5 proteins:
Pseudogenes.org Pseudogenes for ARF3 Gene
Variants for ARF3 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000314829 | -- | 48,940,062(+) | CCCAC(A/G)CTGTA | reference, missense | |
| rs1000418782 | -- | 48,931,799(+) | ATTTA(C/T)AACAG | intron-variant | |
| rs1000455117 | -- | 48,953,427(+) | TTAAA(A/G)AAAGG | intron-variant | |
| rs1000524980 | -- | 48,933,598(+) | TCGGA(A/G)GCTGA | intron-variant | |
| rs1000536951 | -- | 48,945,667(+) | GCAGT(A/G)AGCCG | intron-variant |
Relevant External Links for ARF3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ARF3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARF3 Gene
Disorders for ARF3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cholera |
|
|
| distal hereditary motor neuropathy, type ii |
|
|
| hypotrichosis 3 |
|
|
| cardiomyopathy, dilated, 1p |
|
|
Relevant External Links for ARF3
No data available for UniProtKB/Swiss-Prot and Genatlas for ARF3 Gene
Publications for ARF3 Gene
- Interaction of the PDZ domain of human PICK1 with class I ADP- ribosylation factors. (PMID: 10623590) Takeya R. … Sumimoto H. (Biochem. Biophys. Res. Commun. 2000) 3 4 22 64
- Assignment of human ADP ribosylation factor (ARF) genes ARF1 and ARF3 to chromosomes 1q42 and 12q13, respectively. (PMID: 8661066) Hirai M. … Hashimoto K. (Genomics 1996) 2 3 22 64
- Isolation and characterization of the human gene for ADP-ribosylation factor 3, a 20-kDa guanine nucleotide-binding protein activator of cholera toxin. (PMID: 1744102) Tsai S.C. … Vaughan M. (J. Biol. Chem. 1991) 3 4 22 64
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
Products for ARF3 Gene
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- antibodies-online Antibodies for ARF3: See all 27
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- Cyagen custom Knockout/knockin (KOKI) mouse models for ARF3
- VectorBuilder custom plasmid, inducible vectors for ARF3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ARF3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ARF3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
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- (28) RNAdb
- (29) ASD
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- (31) GeneAnnot
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- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
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- (37) SGD
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- (40) Pseudogene
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- (50) eBioscience
- (51) Atlas
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- (53) GenBank
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- (62) NCBI
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- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
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- (78) MOPED
- (79) SPIRE
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- (92) Vector BioLabs
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- (141) ENCODE
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- (143) Horizon
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- (145) IID
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- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




