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Aliases for ARF3 Gene

Aliases for ARF3 Gene

  • ADP-Ribosylation Factor 3 2 3
  • Small GTP Binding Protein 2

External Ids for ARF3 Gene

Previous GeneCards Identifiers for ARF3 Gene

  • GC12M049256
  • GC12M049556
  • GC12M049046
  • GC12M047616
  • GC12M049329
  • GC12M046361
  • GC12M049299

Summaries for ARF3 Gene

Entrez Gene Summary for ARF3 Gene

  • ADP-ribosylation factor 3 (ARF3) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6) and members of each class share a common gene organization. The ARF3 gene contains five exons and four introns. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARF3 Gene

ARF3 (ADP-Ribosylation Factor 3) is a Protein Coding gene. Diseases associated with ARF3 include distal hereditary motor neuropathy, type ii and cholera. Among its related pathways are GPCR Pathway and Metabolism. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is ENSG00000272822.

UniProtKB/Swiss-Prot for ARF3 Gene

  • GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus

Gene Wiki entry for ARF3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARF3 Gene

Genomics for ARF3 Gene

Regulatory Elements for ARF3 Gene

Genomic Location for ARF3 Gene

48,931,264 bp from pter
48,957,551 bp from pter
26,288 bases
Minus strand

Genomic View for ARF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARF3 Gene

Proteins for ARF3 Gene

  • Protein details for ARF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP-ribosylation factor 3
    Protein Accession:
    Secondary Accessions:
    • A8K6G8
    • B7ZB63
    • P16587

    Protein attributes for ARF3 Gene

    181 amino acids
    Molecular mass:
    20601 Da
    Quaternary structure:
    • Interacts with PRKCABP. Interacts with PI4KB and NCS1/FREQ at the Golgi complex.

    Alternative splice isoforms for ARF3 Gene


neXtProt entry for ARF3 Gene

Proteomics data for ARF3 Gene at MOPED

Post-translational modifications for ARF3 Gene

  • Ubiquitination at Lys15, Lys73, Lys127, and Lys142
  • Modification sites at PhosphoSitePlus

Other Protein References for ARF3 Gene

No data available for DME Specific Peptides for ARF3 Gene

Domains for ARF3 Gene

Gene Families for ARF3 Gene

  • ARF :ADP-ribosylation factors

Protein Domains for ARF3 Gene

Suggested Antigen Peptide Sequences for ARF3 Gene

Graphical View of Domain Structure for InterPro Entry



  • P61204
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARF3: view

Function for ARF3 Gene

Molecular function for ARF3 Gene

GENATLAS Biochemistry: ADP ribosylation factor 3,class I,low molecular weight GTP binding protein,a guanine nucleotide dependent protein activator of cholera toxin,with two transcripts resulting from alternative use of polyadenylation transcripts,(20kDa),widely expressed,especially in brain,Ras superfamily member,involved in vesicular trafficking and activation of phospholipase D
UniProtKB/Swiss-Prot Function: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus

Gene Ontology (GO) - Molecular Function for ARF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 1744102
GO:0004871 signal transducer activity --
GO:0005525 GTP binding IEA --
GO:0019001 guanyl nucleotide binding --
GO:0031683 G-protein beta/gamma-subunit complex binding --
genes like me logo Genes that share ontologies with ARF3: view

Phenotypes for ARF3 Gene

genes like me logo Genes that share phenotypes with ARF3: view

miRNA for ARF3 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARF3 Gene

Localization for ARF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARF3 Gene

Golgi apparatus. Cytoplasm, perinuclear region.

Subcellular locations from

Jensen Localization Image for ARF3 Gene COMPARTMENTS Subcellular localization image for ARF3 gene
Compartment Confidence
golgi apparatus 5
cytosol 3
cytoskeleton 2
endosome 2
mitochondrion 2
plasma membrane 2
endoplasmic reticulum 1
extracellular 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ARF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0005794 Golgi apparatus --
genes like me logo Genes that share ontologies with ARF3: view

Pathways for ARF3 Gene

genes like me logo Genes that share pathways with ARF3: view

Pathways by source for ARF3 Gene

Gene Ontology (GO) - Biological Process for ARF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006644 phospholipid metabolic process TAS --
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0006886 intracellular protein transport --
GO:0007186 G-protein coupled receptor signaling pathway --
genes like me logo Genes that share ontologies with ARF3: view

Compounds for ARF3 Gene

(1) HMDB Compounds for ARF3 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP

(4) Novoseek inferred chemical compound relationships for ARF3 Gene

Compound -log(P) Hits PubMed IDs
gdp 62.4 4
gtp 58.3 2
lipoteichoic acid 56.1 1
lipid 0 1
genes like me logo Genes that share compounds with ARF3: view

Transcripts for ARF3 Gene

mRNA/cDNA for ARF3 Gene

Unigene Clusters for ARF3 Gene

ADP-ribosylation factor 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARF3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - - - - - - - - - - - - - - -
SP7: -
SP8: - - - - - - - - - - - - - - - - - -
SP10: - -

Relevant External Links for ARF3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARF3 Gene

mRNA expression in normal human tissues for ARF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARF3 Gene

SOURCE GeneReport for Unigene cluster for ARF3 Gene Hs.119177

genes like me logo Genes that share expressions with ARF3: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARF3 Gene

Orthologs for ARF3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARF3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARF3 35
  • 100 (n)
  • 100 (a)
(Bos Taurus)
Mammalia ARF3 35
  • 95.76 (n)
  • 100 (a)
(Canis familiaris)
Mammalia ARF1 36
  • 100 (a)
ARF3 35
  • 95.58 (n)
  • 100 (a)
(Mus musculus)
Mammalia Arf3 35
  • 92.82 (n)
  • 100 (a)
Arf3 16
Arf3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Arf3 35
  • 91.71 (n)
  • 100 (a)
(Anolis carolinensis)
Reptilia ARF3 36
  • 100 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6539 35
tropical clawed frog
(Silurana tropicalis)
Amphibia arf3 35
  • 83.79 (n)
  • 100 (a)
(Danio rerio)
Actinopterygii arf3a 35
  • 81.77 (n)
  • 99.45 (a)
arf3b 36
  • 100 (a)
fruit fly
(Drosophila melanogaster)
Insecta Arf79F 36
  • 93 (a)
Arf102F 37
  • 81 (a)
Arf79F 37
  • 94 (a)
(Caenorhabditis elegans)
Secernentea arf-1.2 36
  • 92 (a)
arl-6 37
  • 61 (a)
arf-1 37
  • 92 (a)
arf-3 37
  • 84 (a)
arl-query 37
  • 41 (a)
arl-5 37
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARF1 36
  • 76 (a)
ARF2 36
  • 75 (a)
(Glycine max)
eudicotyledons Gma.11398 35
thale cress
(Arabidopsis thaliana)
eudicotyledons ARFA1E 35
  • 75.37 (n)
  • 88.33 (a)
(Oryza sativa)
Liliopsida Os07g0223400 35
  • 76.85 (n)
  • 86.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 74 (a)
Species with no ortholog for ARF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARF3 Gene

Gene Tree for ARF3 (if available)
Gene Tree for ARF3 (if available)

Paralogs for ARF3 Gene Pseudogenes for ARF3 Gene

genes like me logo Genes that share paralogs with ARF3: view

Variants for ARF3 Gene

Sequence variations from dbSNP and Humsavar for ARF3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs12122 -- 48,940,979(-) AAACT(C/G)GGGGA reference, synonymous-codon
rs708242 -- 48,940,261(+) GTTAA(C/G)CTAGC intron-variant
rs833820 -- 48,954,036(+) ACCTA(A/C)AATAA intron-variant
rs833821 -- 48,955,153(+) GTAAA(A/C)GAGTA intron-variant
rs833822 -- 48,955,222(+) TCTTT(C/G)CAGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARF3 Gene

Variant ID Type Subtype PubMed ID
nsv832404 CNV Gain 17160897
nsv899067 CNV Loss 21882294

Relevant External Links for ARF3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARF3 Gene

Disorders for ARF3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for ARF3 Gene including...

Search for ARF3 Gene in MalaCards »

(2) University of Copenhagen DISEASES for ARF3 Gene

(1) Novoseek inferred disease relationships for ARF3 Gene

Disease -log(P) Hits PubMed IDs
cholera 53.9 1

Relevant External Links for ARF3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ARF3: view

No data available for UniProtKB/Swiss-Prot for ARF3 Gene

Publications for ARF3 Gene

  1. Assignment of human ADP ribosylation factor (ARF) genes ARF1 and ARF3 to chromosomes 1q42 and 12q13, respectively. (PMID: 8661066) Hirai M. … Hashimoto K. (Genomics 1996) 2 3 23
  2. Isolation and characterization of the human gene for ADP-ribosylation factor 3, a 20-kDa guanine nucleotide-binding protein activator of cholera toxin. (PMID: 1744102) Tsai S.C. … Vaughan M. (J. Biol. Chem. 1991) 3 4 23
  3. Interaction of the PDZ domain of human PICK1 with class I ADP- ribosylation factors. (PMID: 10623590) Takeya R. … Sumimoto H. (Biochem. Biophys. Res. Commun. 2000) 3 4 23
  4. Characterization of the human ADP-ribosylation factor 3 promoter. Transcriptional regulation of a TATA-less promoter. (PMID: 8473323) Haun R.S. … Vaughan M. (J. Biol. Chem. 1993) 3 23
  5. Arfaptin 1 forms a complex with ADP-ribosylation factor and inhibits phospholipase D. (PMID: 10413101) Williger B.-T. … Exton J.H. (FEBS Lett. 1999) 3 23

Products for ARF3 Gene

  • Addgene plasmids for ARF3

Sources for ARF3 Gene

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