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ARF3 Gene

protein-coding   GIFtS: 64
GCID: GC12M049329

ADP-Ribosylation Factor 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADP-Ribosylation Factor 31 2
Small GTP Binding Protein1 2

External Ids:    HGNC: 6541   Entrez Gene: 3772   Ensembl: ENSG000001342877   OMIM: 1031905   UniProtKB: P612043   

Export aliases for ARF3 gene to outside databases

Previous GC identifers: GC12M049256 GC12M049556 GC12M049046 GC12M047616 GC12M046361 GC12M049299


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARF3 Gene:
ADP-ribosylation factor 3 (ARF3) is a member of the human ARF gene family. These genes encode small guanine
nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role
in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11
ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I
(ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6) and members of each class share a common
gene organization. The ARF3 gene contains five exons and four introns. (provided by RefSeq, Jul 2008)

GeneCards Summary for ARF3 Gene:
ARF3 (ADP-ribosylation factor 3) is a protein-coding gene. Diseases associated with ARF3 include distal hereditary motor neuropathy, type ii, and cholera. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is ARL2.

UniProtKB/Swiss-Prot: ARF3_HUMAN, P61204
Function: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an
ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the
Golgi apparatus

Gene Wiki entry for ARF3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARF3 gene promoter:
         SREBP-1c   E2F-2   HNF-4alpha2   HNF-4alpha1   SREBP-1b   SREBP-1a   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARF3 promoter sequence
   Search Chromatin IP Primers for ARF3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13.12

ARF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARF3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M049329:  view genomic region     (about GC identifiers)

Start:
49,329,506 bp from pter      End:
49,351,334 bp from pter
Size:
21,829 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ARF3_HUMAN, P61204 (See protein sequence)
Recommended Name: ADP-ribosylation factor 3  
Size: 181 amino acids; 20601 Da
Subunit: Interacts with PRKCABP. Interacts with PI4KB and NCS1/FREQ at the Golgi complex
Secondary accessions: A8K6G8 P16587

Explore the universe of human proteins at neXtProt for ARF3: NX_P61204

Explore proteomics data for ARF3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys15, Lys73, Lys127, Lys142
  • Modification sites at PhosphoSitePlus

  • See ARF3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001650.1  
    ENSEMBL proteins: 
     ENSP00000256682   ENSP00000395370   ENSP00000438510   ENSP00000438063   ENSP00000437374  
     ENSP00000446353  
    Reactome Protein details: P61204

    ARF3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARF: ADP-ribosylation factors

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR027417 P-loop_NTPase
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF

    Graphical View of Domain Structure for InterPro Entry P61204

    ProtoNet protein and cluster: P61204

    UniProtKB/Swiss-Prot: ARF3_HUMAN, P61204
    Similarity: Belongs to the small GTPase superfamily. Arf family


    ARF3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARF3_HUMAN, P61204
    Function: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an
    ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the
    Golgi apparatus

         Genatlas biochemistry entry for ARF3:
    ADP ribosylation factor 3,class I,low molecular weight GTP binding protein,a guanine nucleotide dependent protein
    activator of cholera toxin,with two transcripts resulting from alternative use of polyadenylation
    transcripts,(20kDa),widely expressed,especially in brain,Ras superfamily member,involved in vesicular trafficking
    and activation of phospholipase D

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS1744102
    GO:0004871signal transducer activity ----
    GO:0005525GTP binding IEA--
    GO:0019001guanyl nucleotide binding ----
    GO:0031683G-protein beta/gamma-subunit complex binding ----
         
    ARF3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ARF3:
     Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARF3
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    miRNA
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    miRTarBase miRNAs that target ARF3:
    hsa-mir-10a-5p (MIRT047633), hsa-mir-125b-5p (MIRT045938), hsa-mir-1 (MIRT002742), hsa-mir-320a (MIRT044395), hsa-mir-30c-5p (MIRT047965)

    Block miRNA regulation of human, mouse, rat ARF3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARF3 (see all 55):
    hsa-miR-21* hsa-miR-3130-5p hsa-miR-513a-5p hsa-miR-128 hsa-miR-4330 hsa-miR-509-3-5p hsa-miR-324-5p hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidARF3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARF3

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    GenScript: all cDNA clones in your preferred vector: ARF3 (NM_001659)
    Sino Biological Human cDNA Clone for ARF3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARF3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARF3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARF3_HUMAN, P61204: Golgi apparatus. Cytoplasm, perinuclear region
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol3
    cytoskeleton2
    endosome2
    mitochondrion2
    plasma membrane2
    endoplasmic reticulum1
    extracellular1
    nucleus1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus ----

    ARF3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARF3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1PI Metabolism
    PI Metabolism0.65
    Synthesis of PIPs at the Golgi membrane0.00
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3GPCR Pathway
    Paxillin Interactions0.73
    4Glycerophospholipid biosynthesis
    Phospholipid metabolism0.64
    5Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Cholera Infection0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ARF3
        Cholera Infection
    Paxillin Interactions


    1 Reactome Pathway for ARF3
        Synthesis of PIPs at the Golgi membrane



    ARF3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARF3
    Interactions:

        GeneGlobe Interaction Network for ARF3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARF3 (P612043 ENSP000002566824) via UniProtKB, MINT, STRING, and/or I2D (see all 114)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARFIP2P533653, ENSP000002545844I2D: score=3 STRING: ENSP00000254584
    ARFIP1P533673, ENSP000002965574I2D: score=2 STRING: ENSP00000296557
    ATN1P542593, ENSP000003490764I2D: score=2 STRING: ENSP00000349076
    KIF23Q022413, ENSP000002603634I2D: score=2 STRING: ENSP00000260363
    GGA1Q9UJY53, ENSP000003413444I2D: score=1 STRING: ENSP00000341344
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS1744102
    GO:0006644phospholipid metabolic process TAS--
    GO:0006661phosphatidylinositol biosynthetic process TAS--
    GO:0006886intracellular protein transport ----
    GO:0007186G-protein coupled receptor signaling pathway ----

    ARF3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARF3

    1 HMDB Compound for ARF3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    4 Novoseek inferred chemical compound relationships for ARF3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 62.4 5 11150519 (2), 9050849 (1), 17227842 (1)
    gtp 58.3 2 8290961 (1), 17227842 (1)
    lipoteichoic acid 56.1 1 15064466 (1)
    lipid 0 1 7575443 (1)



    ARF3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARF3 gene: 
    NM_001659.2  

    Unigene Cluster for ARF3:

    ADP-ribosylation factor 3
    Hs.119177  [show with all ESTs]
    Unigene Representative Sequence: M74491
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256682(uc001rsr.2 uc010smc.1) ENST00000485410 ENST00000447318
    ENST00000541959 ENST00000541236 ENST00000539611 ENST00000545855 ENST00000541967
    ENST00000472621 ENST00000536283
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    hsa-miR-21* hsa-miR-3130-5p hsa-miR-513a-5p hsa-miR-128 hsa-miR-4330 hsa-miR-509-3-5p hsa-miR-324-5p hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidARF3 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat ARF3
      QuantiFast Probe-based Assays in human, mouse, rat ARF3

    Additional mRNA sequence: 

    AF493882.1 AK291633.1 AK300080.1 AK303726.1 AK309899.1 AK315970.1 AK316528.1 BC007647.1 
    BC007762.2 BC017565.2 BC028402.2 BT006670.1 M74491.1 

    Selected DOTS entries (see all 32):

    DT.92403904  DT.75113000  DT.100826563  DT.219676  DT.95087025  DT.100826559  DT.75135167  DT.100045064 
    DT.100045065  DT.121151631  DT.92455636  DT.100826557  DT.121151576  DT.95342211  DT.97799479  DT.100826560 
    DT.121151541  DT.121151581  DT.121151584  DT.121151612  DT.121151617  DT.121151629  DT.121151640  DT.92455631 

    10 AceView cDNA sequences:

    CR607986 BC017565 BC007762 BC028402 BC007647 NM_001659 AF493882 BT006670 
    M74491 M33384 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARF3 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c
    SP1:                                -     -     -     -     -     -     -     -     -                                                                     
    SP2:                                -     -     -     -     -     -     -     -     -                 -     -                                             
    SP3:                                -     -     -     -     -     -     -     -     -                       -     -                                       
    SP4:                                -     -     -     -     -                 -                                                                           
    SP5:                                      -     -     -                       -     -                                                                     


    ECgene alternative splicing isoforms for ARF3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARF3 expression in normal human tissues (normalized intensities)      ARF3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGACTTTGC
    ARF3 Expression
    About this image


    ARF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Kidney (Urinary System)
             Metanephros
    ARF3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARF3 Protein Expression

    Genevestigator expression for ARF3

    SOURCE GeneReport for Unigene cluster: Hs.119177
        Custom PCR Arrays for ARF3
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARF3 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arf31 , 5 ADP-ribosylation factor 31, 5 92.82(n)1
    100(a)1
      15 (54.65 cM)5
    118421  NM_007478.31  NP_031504.11 
     987376215 
    lizard
    (Anolis carolinensis)
    Reptilia ARF36
    ADP-ribosylation factor 3
    100(a)
    1 ↔ 1
    2(94127673-94145297)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.65392 Xenopus laevis transcribed sequence with strong similarity more 83.57(n)    BU914466.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC050487.12   -- 83.07(n)    BC050487.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Arf79F3 protein amino acid ADP-ribosylation GTP
    binding
    94(a)
    (best of 2)
      80B2   --
    worm
    (Caenorhabditis elegans)
    Secernentea arf-13 ARF 92(a)
    (best of 5)
      III(5787540-5788738)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARF16
    ARF26
    ADP-ribosylation factor, GTPase of the Ras superfa...
    ADP-ribosylation factor, GTPase of the Ras superfa...
    76(a)
    75(a)
    many ↔ many
    many ↔ many
    IV(116321-116866) YDL192W
    IV(216529-217074) YDL137W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ARFA1E1 ARFA1E 75.37(n)
    88.33(a)
      825402  NM_001203232.1  NP_001190161.1 
    rice
    (Oryza sativa)
    Liliopsida AK105508.12   -- 81.43(n)    AK105508.1 


    ENSEMBL Gene Tree for ARF3 (if available)
    TreeFam Gene Tree for ARF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARF3 gene
    ARL22  ARL5B2  ENSG000002730032  ARL5C2  ARF42  ENSG000002728222  ARF52  ARF12  
    ARL32  ARL5A2  ARF62  TRIM232  
    Selected SIMAP similar genes for ARF3 using alignment to 5 protein entries:     ARF3_HUMAN (see all proteins) (see all similar genes):
    ARF1    ARL17B    ARL17A    ARF4    ARL1    ARF5
    TRIM23    ARF6    ARL14    ARL4D    ARL11    ARL2
    ARL4A    ARL8B    ARL5A    RAB15    RAB8B    ARL5B

    ARF3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ARF3
    PGOHUM00000248484 PGOHUM00000259233


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARF3 (see all 464)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1121425601,2
    C--46384700(+) CTTGCT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.00CSA 2
    rs2018390341,2
    C--46384715(+) TTTTTC/TTGTTT 1 -- us2k10--------
    rs619422071,2
    C,F--46384774(+) GCACTC/TTGGGA 1 -- us2k12Minor allele frequency- T:0.50NA CSA 4
    rs590872361,2
    C,F--46384793(+) CAGGCA/GGATCA 1 -- us2k19Minor allele frequency- G:0.44WA NA CSA EA 252
    rs1910289631,2
    C--46384821(+) AGATCA/GAGAAC 1 -- us2k10--------
    rs1824547071,2
    --46385078(+) GTTGCA/TGAGGC 1 -- us2k10--------
    rs797446991,2
    C,F--49329509(+) CAGACG/ATTTAT 1 -- ds50012Minor allele frequency- A:0.08NA 122
    rs171233981,2
    C,F,H--49329527(+) GTTTAT/CTCACT 1 -- ds50018Minor allele frequency- C:0.05NA NS EA WA 668
    rs1497393861,2
    C--49329558(+) AGTGA-/GGGGGG 1 -- ds50010--------
    rs1810970401,2
    --49329563(+) AGGGGA/GTCTCT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ARF3 (49329506 - 49351334 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ARF3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899067CNV Loss21882294
    nsv832404CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARF3
    DNA2.0 Custom Variant and Variant Library Synthesis for ARF3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 103190    OMIM disorders: --

    12 diseases for ARF3:    About MalaCards
    distal hereditary motor neuropathy, type ii    cholera    distal hereditary motor neuropathy    platelet storage pool deficiency
    gout    neuropathy    chronic lymphocytic leukemia    ataxia
    neuroblastoma    leukemia    endotheliitis    cerebritis

    2 diseases from the University of Copenhagen DISEASES database for ARF3:
    Platelet storage pool deficiency     Cholera

    ARF3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ARF3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholera 53.9 1 1744102 (1)

    Genetic Association Database (GAD): ARF3
    Human Genome Epidemiology (HuGE) Navigator: ARF3 (3 documents)

    Export disorders for ARF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARF3 gene, integrated from 10 sources (see all 78):
    (articles sorted by number of sources associating them with ARF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of human ADP ribosylation factor (ARF) genes ARF1 and ARF3 to chromosomes 1q42 and 12q13, respectively. (PubMed id 8661066)1, 3, 9 Hirai M....Hashimoto K. (Genomics 1996)
    2. Isolation and characterization of the human gene for ADP-ribosylation factor 3, a 20-kDa guanine nucleotide-binding protein activator of cholera toxin. (PubMed id 1744102)1, 2, 9 Tsai S.C.... Vaughan M. (J. Biol. Chem. 1991)
    3. Interaction of the PDZ domain of human PICK1 with class I ADP- ribosylation factors. (PubMed id 10623590)1, 2, 9 Takeya R.... Sumimoto H. (Biochem. Biophys. Res. Commun. 2000)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Molecular cloning, characterization, and expression of human ADP- ribosylation factors: two guanine nucleotide-dependent activators of cholera toxin. (PubMed id 2474826)1, 2 Bobak D.A....Vaughan M. (Proc. Natl. Acad. Sci. U.S.A. 1989)
    7. Characterization of the human ADP-ribosylation factor 3 promoter. Transcriptional regulation of a TATA-less promoter. (PubMed id 8473323)1, 9 Haun R.S....Vaughan M. (J. Biol. Chem. 1993)
    8. A family of ADP-ribosylation factor effectors that can alter transport through the trans-Golgi. (PubMed id 10749927)1, 9 Boman A.L.... Kahn R.A. (Mol. Biol. Cell 2000)
    9. Arfaptin 1 forms a complex with ADP-ribosylation factor and inhibits phospholipase D. (PubMed id 10413101)1, 9 Williger B.-T.... Exton J.H. (FEBS Lett. 1999)
    10. Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. (PubMed id 23464991)1 Scifo E....Lalowski M. (J. Proteome Res. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 377 HGNC: 654 AceView: ARF3 Ensembl:ENSG00000134287 euGenes: HUgn377
    ECgene: ARF3 H-InvDB: ARF3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ARF3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARF3 gene:
    Search GeneIP for patents involving ARF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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