Aliases for ARF1 Gene
External Ids for ARF1 Gene
- HGNC: 652
- Entrez Gene: 375
- Ensembl: ENSG00000143761
- OMIM: 103180
- UniProtKB: P84077
Previous GeneCards Identifiers for ARF1 Gene
- GC01P226767
- GC01P224008
- GC01P224655
- GC01P225244
- GC01P224577
- GC01P226336
- GC01P228270
- GC01P198785
Summaries for ARF1 Gene
-
ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ARF1 Gene
ARF1 (ADP Ribosylation Factor 1) is a Protein Coding gene. Diseases associated with ARF1 include Cholera and Rheumatic Myocarditis. Among its related pathways are Clathrin derived vesicle budding and Arf1 pathway. GO annotations related to this gene include poly(A) RNA binding and GTPase activity. An important paralog of this gene is ARF3.
UniProtKB/Swiss-Prot for ARF1 Gene
-
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARF1 Gene
Genomics for ARF1 Gene
Regulatory Elements for ARF1 Gene
Enhancers for ARF1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH01G228059 | 1.1 | Ensembl ENCODE | 12.8 | -22.5 | -22472 | 2.2 | ARNT GLIS2 EGR1 KLF13 EGR2 SP3 ELF1 SP1 ZNF341 IKZF1 | OBSCN ARF1 WNT3A OBSCN-AS1 GC01P228076 |
| GH01G228455 | 1.4 | ENCODE dbSUPER | 9.7 | +375.2 | 375230 | 4.1 | CREB3L1 AGO1 DMAP1 FEZF1 YBX1 ZNF143 ZNF263 MCM3 SP3 ZFP41 | CICP26 C1orf35 HIST3H3 ENSG00000231563 OBSCN ARF1 HIST3H2A HIST3H2BB |
| GH01G228081 | 1.7 | FANTOM5 ENCODE dbSUPER | 3.3 | +3.9 | 3896 | 10.7 | CREB3L1 AGO1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 ZNF610 ZNF585B | CICP26 OBSCN ENSG00000269890 C1orf35 WNT3A ENSG00000231563 ENSG00000269934 OBSCN-AS1 ARF1 MIR3620 |
| GH01G227937 | 0.5 | FANTOM5 | 1.7 | -145.5 | -145482 | 0.1 | GATA3 TARDBP DPF2 | ARF1 MIR5008 PRSS38 |
| GH01G228096 | 0.6 | ENCODE | 0.4 | +13.4 | 13448 | 0.1 | ZFHX2 POLR2A ZNF837 GLIS1 ZIC2 ZNF18 EGR2 | MIR3620 ARF1 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ARF1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ARF1 gene promoter:
Regulatory Element Products
Genomic Location for ARF1 Gene
- Chromosome:
- 1
- Start:
- 228,082,660 bp from pter
- End:
- 228,099,212 bp from pter
- Size:
- 16,553 bases
- Orientation:
- Plus strand
Genomic View for ARF1 Gene
Genes around ARF1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q42.13 by Ensembl
- 1q42.13 by Entrez Gene
- 1q42.13 by HGNC
ARF1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ARF1 Gene
Proteins for ARF1 Gene
-
Protein details for ARF1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P84077-ARF1_HUMAN
- Recommended name:
- ADP-ribosylation factor 1
- Protein Accession:
- P84077
- P10947
- P32889
Protein attributes for ARF1 Gene
- Size:
- 181 amino acids
- Molecular mass:
- 20697 Da
- Quaternary structure:
-
- Interacts with ARHGAP21, ASAP2, GGA1, HERC1, PRKCABP, PIP5K1B, TMED2, PSCD2, TMED10 and GRIA2. Interacts with ARFGAP1, which hydrolyzes GTP and thus, regulates its function. Interacts with PI4KB in the Golgi complex. Interacts with NCS1/FREQ in the Golgi and at the plasma membrane. Interacts with PLEKHA3. Interacts with PLEKHA8; the interaction, together with phosphatidylinositol 4-phosphate binding, is required for FAPP2-mediated glucosylceramide transfer activity. Interacts (activated) with PICK1 (via PDZ domain); the interaction blocks Arp2/3 complex inhibition. Interacts with IQSEC1 (PubMed:24058294).
Protein Expression for ARF1 Gene
Post-translational modifications for ARF1 Gene
- Demyristoylated by S.flexneri cysteine protease IpaJ which cleaves the peptide bond between N-myristoylated Gly-2 and Asn-3.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for ARF1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for ARF1
-
Custom Antibody ServicesOriGene Antibodies for ARF1
- Novus Biologicals Antibodies for ARF1
- Invitrogen Antibodies for ARF1
- antibodies-online Antibodies for ARF1: See all 88
- GeneTex ARF1 antibody for ARF1
-
Santa Cruz Biotechnology (SCBT) Antibodies for ARF1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for ARF1
- Origene Custom Protein Services for ARF1
- Sino Biological Recombinant Proteins for ARF1
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for ARF1
- antibodies-online Proteins for ARF1: See all 34
- Search antibodies-online for peptides
- Search GeneTex for Proteins for ARF1
Assay Products
- antibodies-online Kits for ARF1: See all 4
No data available for DME Specific Peptides for ARF1 Gene
Domains & Families for ARF1 Gene
Gene Families for ARF1 Gene
Protein Domains for ARF1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ARF1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P84077- Family:
-
- Belongs to the small GTPase superfamily. Arf family.
Function for ARF1 Gene
Molecular function for ARF1 Gene
- GENATLAS Biochemistry:
- ADP ribosylation factor 1,class I,low molecular weight GTP binding protein (20kDa),widely expressed,a guanine nucleotide dependent protein activator of cholera toxin,Ras superfamily member,involved in the coating of vesicles that bud from Golgi compartments and vesicular trafficking,through interaction with ARF exchange factor such as cytohesin- 1 (PSCD1),ARNO (PSCD2),PSCD2L
- UniProtKB/Swiss-Prot Function:
- GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0000287 | magnesium ion binding | IEA | -- |
| GO:0003723 | RNA binding | IDA | 22681889 |
| GO:0003924 | GTPase activity | TAS | -- |
| GO:0005057 | signal transducer activity, downstream of receptor | TAS | 8529647 |
Phenotypes for ARF1 Gene
- MGI mutant phenotypes for ARF1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ARF1:
-
- Increased viability
- Increased gamma-H2AX phosphorylation
- Decreased viability in esophageal squamous lineage
- Decreased p24 protein expression
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased Salmonella enterica Typhimurium binding
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased lymphocytic choriomeningitis virus (LCMV) infection
Animal Models for ARF1 Gene
- MGI Knock Outs for ARF1:
-
- Arf1 tm1.1Towa
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ARF1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ARF1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ARF1 gene
- Search ViGene Biosciences for ARF1
CRISPR Products
-
OriGene CRISPR knockouts for ARF1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARF1
- GenScript: Design CRISPR guide RNA sequences for ARF1
miRNA for ARF1 Gene
- miRTarBase miRNAs that target ARF1
-
- hsa-mir-320b (MIRT036212)
- hsa-mir-296-3p (MIRT038364)
- hsa-mir-615-3p (MIRT040063)
- hsa-mir-324-5p (MIRT043175)
- hsa-mir-30b-5p (MIRT046160)
- hsa-mir-30c-5p (MIRT047891)
- hsa-mir-92a-3p (MIRT049435)
- hsa-mir-4738-3p (MIRT247785)
- hsa-mir-548av-3p (MIRT247786)
- hsa-mir-1282 (MIRT271959)
- hsa-mir-4712-3p (MIRT271960)
- hsa-mir-3064-3p (MIRT271961)
- hsa-mir-25-3p (MIRT271962)
- hsa-mir-32-5p (MIRT271963)
- hsa-mir-95-5p (MIRT271964)
- hsa-mir-153-3p (MIRT271965)
- hsa-mir-320a (MIRT271966)
- hsa-mir-363-3p (MIRT271967)
- hsa-mir-367-3p (MIRT271968)
- hsa-mir-92b-3p (MIRT271969)
- hsa-mir-624-5p (MIRT271970)
- hsa-mir-320c (MIRT271971)
- hsa-mir-320d (MIRT271974)
- hsa-mir-1911-5p (MIRT271975)
- hsa-mir-4429 (MIRT271977)
- hsa-mir-8077 (MIRT271982)
- hsa-mir-548d-3p (MIRT271988)
- hsa-mir-548h-3p (MIRT271989)
- hsa-mir-548t-3p (MIRT271990)
- hsa-mir-548z (MIRT271991)
- hsa-mir-548aa (MIRT271992)
- hsa-mir-548ac (MIRT271993)
- hsa-mir-4682 (MIRT271994)
- hsa-mir-548ap-3p (MIRT271995)
- hsa-mir-6740-5p (MIRT271996)
- hsa-mir-548bb-3p (MIRT271997)
- hsa-mir-548j-3p (MIRT336798)
- hsa-mir-548x-3p (MIRT336799)
- hsa-mir-4261 (MIRT336800)
- hsa-mir-548ae-3p (MIRT336801)
- hsa-mir-548ah-3p (MIRT336802)
- hsa-mir-548aj-3p (MIRT336803)
- hsa-mir-548am-3p (MIRT336804)
- hsa-mir-548aq-3p (MIRT336805)
- hsa-mir-124-5p (MIRT405284)
- hsa-mir-890 (MIRT405287)
- hsa-mir-4255 (MIRT405288)
- hsa-mir-4273 (MIRT405289)
- hsa-mir-5004-3p (MIRT405290)
- hsa-mir-6513-3p (MIRT405291)
- hsa-mir-7156-5p (MIRT405292)
- hsa-mir-4776-3p (MIRT481629)
- hsa-mir-4715-3p (MIRT481630)
- hsa-mir-31-5p (MIRT481631)
- hsa-mir-2467-3p (MIRT481632)
- hsa-mir-3616-3p (MIRT481633)
- hsa-mir-4693-3p (MIRT481634)
- hsa-mir-4433b-3p (MIRT481635)
- hsa-mir-4422 (MIRT481636)
- hsa-mir-6835-3p (MIRT481637)
- hsa-mir-6839-3p (MIRT559562)
- hsa-mir-4507 (MIRT559563)
- hsa-mir-3940-5p (MIRT559564)
- hsa-mir-6776-3p (MIRT559565)
- hsa-mir-2681-5p (MIRT559566)
- hsa-mir-3978 (MIRT559567)
- hsa-mir-448 (MIRT559568)
- hsa-mir-338-5p (MIRT559569)
- hsa-mir-516a-5p (MIRT568502)
- hsa-mir-4465 (MIRT568503)
- hsa-mir-26b-5p (MIRT568504)
- hsa-mir-26a-5p (MIRT568505)
- hsa-mir-1297 (MIRT568506)
- hsa-mir-2117 (MIRT568507)
- hsa-mir-6867-5p (MIRT568508)
- hsa-mir-3182 (MIRT568509)
- hsa-mir-4320 (MIRT568510)
- hsa-mir-1237-3p (MIRT568511)
- hsa-mir-5088-3p (MIRT568512)
- hsa-mir-642b-5p (MIRT660556)
miRNA Products
- Search ViGene Biosciences for ARF1
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for ARF1
- Browse OriGene Inhibitory RNA Products For ARF1
-
ViGene Biosciences ready-to-package AAV shRNAs for ARF1 gene
Clone Products
- Sino Biological Human cDNA Clone for ARF1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for ARF1
- VectorBuilder custom plasmid, inducible vectors for ARF1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ARF1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ARF1
-
ViGene Biosciences adenoviral particle packaged cDNA for ARF1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ARF1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ARF1 gene
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-12293) for ARF1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARF1 Gene
Localization for ARF1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ARF1 Gene
- Golgi apparatus. Cytoplasm, perinuclear region. Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Membrane; Lipid-anchor.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytosol | 5 |
| golgi apparatus | 5 |
| endosome | 4 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005622 | intracellular | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005770 | late endosome | IEA | -- |
| GO:0005778 | peroxisomal membrane | IEA | -- |
Pathways & Interactions for ARF1 Gene
Pathways by source for ARF1 Gene
5 BioSystems pathways for ARF1 Gene
32 Reactome pathways for ARF1 Gene
4 KEGG pathways for ARF1 Gene
3 GeneGo (Thomson Reuters) pathways for ARF1 Gene
2 Qiagen pathways for ARF1 Gene
Interacting Proteins for ARF1 Gene
Selected Interacting proteins:
ENSP00000272102
P84077-ARF1_HUMAN
for ARF1 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002090 | regulation of receptor internalization | ISS | -- |
| GO:0006661 | phosphatidylinositol biosynthetic process | TAS | -- |
| GO:0006810 | transport | IEA | -- |
| GO:0006878 | cellular copper ion homeostasis | IMP | 21034850 |
| GO:0006892 | post-Golgi vesicle-mediated transport | TAS | -- |
No data available for SIGNOR curated interactions for ARF1 Gene
Drugs & Compounds for ARF1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Glycerol | Approved, Experimental | Pharma | Target | 238 | ||
| Guanosine triphosphate | Experimental | Pharma | Target | 0 | ||
| 1,3-Propandiol | Experimental | Pharma | Target | 0 | ||
| 1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE | Experimental | Pharma | Target | 0 | ||
| Guanosine diphosphate | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- Enzo Life Sciences drugs & compounds for ARF1
Transcripts for ARF1 Gene
mRNA/cDNA for ARF1 Gene
- (5) REFSEQ mRNAs :
- (18) Additional mRNA sequences :
- (1523) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ARF1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ARF1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ARF1
- GenScript: Design CRISPR guide RNA sequences for ARF1
miRNA Products
- Search ViGene Biosciences for ARF1
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for ARF1
- Browse OriGene Inhibitory RNA Products For ARF1
-
ViGene Biosciences ready-to-package AAV shRNAs for ARF1 gene
Clone Products
- Sino Biological Human cDNA Clone for ARF1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for ARF1
- VectorBuilder custom plasmid, inducible vectors for ARF1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ARF1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-12293) for ARF1
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | · | 9c | · | 9d | · | 9e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - |
Expression for ARF1 Gene
This gene is overexpressed in Blymphocyte (11.7), Tlymphocyte (10.9), Nasal epithelium (6.4), and Cervix (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARF1 Gene
NURSA nuclear receptor signaling pathways regulating expression of ARF1 Gene:
ARF1SOURCE GeneReport for Unigene cluster for ARF1 Gene:
Hs.286221Evidence on tissue expression from TISSUES for ARF1 Gene
- Nervous system(5)
- Eye(4.9)
- Kidney(4.8)
- Liver(4.8)
- Lung(4.7)
- Intestine(4.5)
- Pancreas(4.3)
- Skin(4.2)
- Heart(3.5)
- Blood(3.3)
- Muscle(3.2)
- Stomach(2.8)
- Adrenal gland(2.5)
- Thyroid gland(2.3)
- Bone(2.2)
- Bone marrow(2.2)
- Gall bladder(2.1)
- Lymph node(2.1)
- Spleen(2.1)
Primer Products
-
OriGene qPCR primer pairs for ARF1
-
OriGene qPCR primer pairs and template standards for ARF1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARF1 Gene
Orthologs for ARF1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ARF1 35 |
|
OneToOne | |
| LOC457177 34 |
|
||||
| dog (Canis familiaris) |
Mammalia | ARF1 35 |
|
OneToOne | |
| LOC607365 34 |
|
||||
| oppossum (Monodelphis domestica) |
Mammalia | ARF1 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Arf1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Arf1 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ARF1 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | ARF1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ARF1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | arf5 34 |
|
||
| MGC76046 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | arf2 35 |
|
ManyToMany | |
| arf1 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Arf102F 36 |
|
|
|
| Arf79F 36 34 35 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012014 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | arf-1 36 |
|
|
|
| arf-3 36 |
|
|
|||
| arf-1.2 34 35 |
|
||||
| arl-6 36 |
|
|
|||
| arl-1 36 |
|
|
|||
| arl-5 36 |
|
|
|||
| arl-query 36 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ARF1 35 |
|
ManyToMany | |
| ARF2 35 37 |
|
ManyToMany | |||
| corn (Zea mays) |
Liliopsida | Zm.6331 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.11304 35 |
|
ManyToMany | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.15067 34 |
|
- Species where no ortholog for ARF1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ARF1 Gene
Paralogs for ARF1 Gene
(30) SIMAP similar genes for ARF1 Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for ARF1 Gene
Variants for ARF1 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000058274 | -- | 228,095,281(+) | CTTGG(G/T)GGGGG | intron-variant, upstream-variant-2KB | |
| rs1000405693 | -- | 228,087,207(+) | TTTGT(A/G)TCATA | intron-variant | |
| rs1000671194 | -- | 228,097,498(+) | TAGAG(A/G)GGGGG | intron-variant, downstream-variant-500B | |
| rs1000928049 | -- | 228,083,818(+) | ACTCC(C/T)TTTCA | intron-variant | |
| rs1001000239 | -- | 228,084,113(+) | CGGCC(A/C)CTGTG | intron-variant |
Residual Variation Intolerance Score:
38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.04;
0.91% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ARF1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARF1 Gene
Disorders for ARF1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cholera |
|
|
| rheumatic myocarditis |
|
|
| robinow syndrome, autosomal dominant 2 |
|
|
Search ARF1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for ARF1
No data available for UniProtKB/Swiss-Prot and Genatlas for ARF1 Gene
Publications for ARF1 Gene
- Characterization of the human gene encoding ADP-ribosylation factor 1, a guanine nucleotide-binding activator of cholera toxin. (PMID: 1577740) Lee C.M. … Vaughan M. (J. Biol. Chem. 1992) 2 3 4 22 64
- Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes. (PMID: 17347647) Menetrey J. … Houdusse A. (EMBO J. 2007) 3 4 22 64
- Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism. (PMID: 14690595) Mossessova E. … Goldberg J. (Mol. Cell 2003) 3 4 22 64
- Structural and functional analysis of the ARF1-ARFGAP complex reveals a role for coatomer in GTP hydrolysis. (PMID: 10102276) Goldberg J. (Cell 1999) 3 4 22 64
- p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins. (PMID: 8861955) Rosa J.L. … Barbacid M. (EMBO J. 1996) 3 4 22 64
Products for ARF1 Gene
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- Custom Antibody ServicesOriGene Antibodies for ARF1
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- Search Origene for MassSpec and Protein Over-expression Lysates for ARF1
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- OriGene qPCR primer pairs and template standards for ARF1
- OriGene qPCR primer pairs for ARF1
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- GenScript: Next-day shipping cDNA ORF clone for ARF1 in any vector
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- Novus Biologicals Antibodies for ARF1
- Novus Biologicals proteins and lysates for ARF1
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- ProSpec Recombinant Proteins for ARF1
- Addgene plasmids for ARF1
- antibodies-online Antibodies for ARF1: See all 88
- antibodies-online Kits for ARF1: See all 4
- antibodies-online Proteins for ARF1: See all 34
- Search antibodies-online for peptides
- GeneTex ARF1 antibody for ARF1
- Search GeneTex for Proteins for ARF1
- ViGene Biosciences adenoviral particle packaged cDNA for ARF1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for ARF1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ARF1 gene
- Search ViGene Biosciences for ARF1
- Santa Cruz Biotechnology (SCBT) Antibodies for ARF1
- Search Santa Cruz Biotechnology (SCBT) for ARF1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ARF1
- Horizon Cell Lines for ARF1
- Cyagen custom Knockout/knockin (KOKI) mouse models for ARF1
- VectorBuilder custom plasmid, inducible vectors for ARF1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ARF1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ARF1 Gene
- (1) GeneCards
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- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
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- (8) Gene Wiki
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- (44) GeneTests
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- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
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- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
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- (88) miRTarBase
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