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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARF1 Gene

protein-coding   GIFtS: 69
GCID: GC01P228270

ADP-Ribosylation Factor 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ADP-Ribosylation Factor 11 2

External Ids:    HGNC: 6521   Entrez Gene: 3752   Ensembl: ENSG000001437617   OMIM: 1031805   UniProtKB: P840773   

Export aliases for ARF1 gene to outside databases

Previous GC identifers: GC01P226767 GC01P224008 GC01P224655 GC01P225244 GC01P224577 GC01P226336 GC01P198785


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARF1 Gene:
ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine
nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role
in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11
ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1,
ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene
organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi
transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this
gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for ARF1 Gene: 
ARF1 (ADP-ribosylation factor 1) is a protein-coding gene. Diseases associated with ARF1 include rheumatic myocarditis, and cholera, and among its related super-pathways are Golgi to ER Retrograde Transport and Clathrin-dependent protein traffic. GO annotations related to this gene include receptor signaling protein activity and GTP binding. An important paralog of this gene is ARL4A.

UniProtKB/Swiss-Prot: ARF1_HUMAN, P84077
Function: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an
ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding
and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to
the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers
the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated
by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles

Gene Wiki entry for ARF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARF1 gene promoter:
         FOXF2   ATF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42   Ensembl cytogenetic band:  1q42.13   HGNC cytogenetic band: 1q42.13

ARF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARF1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P228270:  view genomic region     (about GC identifiers)

Start:
228,270,361 bp from pter      End:
228,286,913 bp from pter
Size:
16,553 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARF1_HUMAN, P84077 (See protein sequence)
Recommended Name: ADP-ribosylation factor 1  
Size: 181 amino acids; 20697 Da
Subunit: Interacts with PRKCABP, GGA1 and PIP5K1B (By similarity). Interacts with ARFGAP1, which hydrolyzes GTP
and thus, regulates its function. Interacts with ASAP2, HERC1 and ARHGAP21. Interacts with PI4KB in the Golgi
complex. Interacts with NCS1/FREQ in the Golgi and at the plasma membrane. This interaction at the plasma
membrane requires a myristoylated NCS1/FREQ. Interacts with TMED2 and TMED10. Interacts with PLEKHA3. Interacts
with PLEKHA8; the interaction, together with phosphatidylinositol 4-phosphate binding, is required for the
FAPP2-mediated glucosylceramide transfer activity
Subcellular location: Golgi apparatus. Cytoplasm, perinuclear region
5 PDB 3D structures from and Proteopedia for ARF1:
1HUR (3D)        1RE0 (3D)        1U81 (3D)        3O47 (3D)        4HMY (3D)    
Secondary accessions: P10947 P32889

Explore the universe of human proteins at neXtProt for ARF1: NX_P84077

Explore proteomics data for ARF1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P84077

  • ARF1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARF1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001019397.1  NP_001019398.1  NP_001019399.1  NP_001649.1  

    ENSEMBL proteins: 
     ENSP00000272102   ENSP00000442980   ENSP00000440005  
    Reactome Protein details: P84077
    Human Recombinant Protein Products for ARF1: 
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    Browse Sino Biological Recombinant Proteins
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    ProSpec Recombinant Protein for ARF1
    Cloud-Clone Corp. Proteins for ARF1 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus ----

    ARF1 for ontologies           About GeneDecksing



    ARF1 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARF: ADP-ribosylation factors

    4 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF
     IPR005225 Small_GTP-bd_dom

    Graphical View of Domain Structure for InterPro Entry P84077

    ProtoNet protein and cluster: P84077

    UniProtKB/Swiss-Prot: ARF1_HUMAN, P84077
    Similarity: Belongs to the small GTPase superfamily. Arf family


    ARF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARF1_HUMAN, P84077
    Function: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an
    ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding
    and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to
    the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers
    the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated
    by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles

         Genatlas biochemistry entry for ARF1:
    ADP ribosylation factor 1,class I,low molecular weight GTP binding protein (20kDa),widely expressed,a guanine
    nucleotide dependent protein activator of cholera toxin,Ras superfamily member,involved in the coating of
    vesicles that bud from Golgi compartments and vesicular trafficking,through interaction with ARF exchange factor
    such as cytohesin- 1 (PSCD1),ARNO (PSCD2),PSCD2L

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS1577740
    GO:0004871signal transducer activity ----
    GO:0005057receptor signaling protein activity TAS8529647
    GO:0005515protein binding IPI10198630
    GO:0005525GTP binding IEA--
         
    ARF1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ARF1:
     Decreased Salmonella enterica   Decreased p24 protein expressi  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ARF1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARF1 
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    SwitchGear 3'UTR luciferase reporter plasmidARF1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARF1 About   (see all 25)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Golgi to ER Retrograde Transport
    Golgi to ER Retrograde Transport0.31
    Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)0.31
    COPI Mediated Transport0.31
    2Clathrin-dependent protein traffic
    Clathrin-dependent protein traffic0.66
    Transport Clathrin-coated vesicle cycle0.66
    3Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    trans-Golgi Network Vesicle Budding0.89
    Golgi Associated Vesicle Biogenesis0.89
    Lysosome Vesicle Biogenesis0.39
    4Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
    Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters0.75
    The role of Nef in HIV-1 replication and disease pathogenesis0.75
    5HIV Life Cycle
    HIV Infection0.61
    Host Interactions of HIV factors0.60

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for ARF1
        Clathrin-dependent protein traffic
    Cytoskeleton remodeling RalA regulation pathway

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ARF1
        Cholera Infection
    Paxillin Interactions

    3 GeneGo (Thomson Reuters) Pathways for ARF1
        Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)
    Transport Clathrin-coated vesicle cycle
    Cytoskeleton remodeling RalA regulation pathway

    5/6 BioSystems Pathways for ARF1 (see all 6)
        Cell cycle
    Insulin Signaling
    Integrated Pancreatic Cancer Pathway
    Class I PI3K signaling events
    Arf6 downstream pathway


    5/21        Reactome Pathways for ARF1 (see all 21)
        Membrane Trafficking
    COPI Mediated Transport
    Clathrin derived vesicle budding
    Metabolism
    The role of Nef in HIV-1 replication and disease pathogenesis


    2         Kegg Pathways  (Kegg details for ARF1):
        Vibrio cholerae infection
    Legionellosis


    ARF1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/97 Interacting proteins for ARF1 (P840771, 2, 3 ENSP000002721024) via UniProtKB, MINT, STRING, and/or I2D (see all 97)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPAG9O602712, 3, ENSP000002620134MINT-7922576 MINT-7922541 MINT-7922558 I2D: score=1 STRING: ENSP00000262013
    ASAP1Q9ULH12, 3, ENSP000003502974MINT-68737 MINT-68738 I2D: score=2 STRING: ENSP00000350297
    WBP11Q9Y2W22, 3, ENSP000002611674MINT-64019 I2D: score=4 STRING: ENSP00000261167
    CYTH2Q994181, 3, ENSP000004082364EBI-447171,EBI-448974 I2D: score=3 STRING: ENSP00000408236
    MYCP011062, 3, ENSP000003672074MINT-4648256 I2D: score=1 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS1577740
    GO:0006644phospholipid metabolic process TAS--
    GO:0006661phosphatidylinositol biosynthetic process TAS--
    GO:0006878cellular copper ion homeostasis IMP--
    GO:0006886intracellular protein transport ----

    ARF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ARF1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARF1

    1 HMDB Compound for ARF1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    7 DrugBank Compounds for ARF1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1,3-Propandiol-- --target--17139284 17016423 10592235
    Glycerol-- --target--17139284 17016423 10592235
    Guanosine-3'-Monophosphate-5'-Diphosphate-- --target--17139284 17016423 10592235
    Guanosine-5'-Diphosphate-- 146-91-8target--17139284 17016423 10592235
    Guanosine-5'-Triphosphate-- 86-01-1target--17139284 17016423 10592235
    1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE-- --target--10592235
    MYRISTIC ACID-- --target--10592235

    10/25 Novoseek inferred chemical compound relationships for ARF1 gene (see all 25)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 83.5 97 9614177 (6), 8106346 (4), 14654841 (4), 19015319 (3) (see all 45)
    gdp 77.5 29 14690595 (2), 7990966 (2), 9649435 (2), 10954741 (2) (see all 16)
    grp-1 75.9 1 10480924 (1)
    adp 69.5 56 10377261 (2), 11726511 (2), 12885418 (2), 15814706 (2) (see all 36)
    guanosine 5'-o-(3-thiotriphosphate) 67.7 7 9346296 (2), 9539714 (1), 10212218 (1), 9614177 (1) (see all 5)
    ptdins(3)p 58.5 4 10657240 (1), 20231409 (1)
    pip2 50.4 8 9065426 (3), 9268368 (2), 8793299 (1)
    c2ceramide 49.9 2 8995404 (1), 14615385 (1)
    phosphatidate 48 1 8793299 (1)
    phosphatidylinositol 46.9 10 11927660 (2), 18990689 (2), 16246097 (1), 11931656 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about ARF1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARF1 gene (4 alternative transcripts): 
    NM_001024226.1  NM_001024227.1  NM_001024228.1  NM_001658.3  

    Unigene Cluster for ARF1:

    ADP-ribosylation factor 1
    Hs.286221  [show with all ESTs]
    Unigene Representative Sequence: AK023803
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000272102 ENST00000477821 ENST00000470670 ENST00000478424 ENST00000470558
    ENST00000473949 ENST00000477451 ENST00000478336 ENST00000469235 ENST00000473546
    ENST00000482962 ENST00000497165 ENST00000490705 ENST00000540651(uc001hrs.3 uc001hrr.3)
    ENST00000541182(uc001hru.3 uc001hrv.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF052179.1 AF055002.1 AF493881.1 AK000620.1 AK023803.1 AK057838.1 AK057875.1 AK130737.1 
    AK293553.1 AK296020.1 AK297792.1 BC009247.2 BC010415.2 BC010429.1 BC011358.1 BT007393.1 
    M36340.1 M84326.1 

    24/70 DOTS entries (see all 70):

    DT.97848008  DT.100691142  DT.100857717  DT.91782057  DT.100691127  DT.100691167  DT.95367313  DT.100865197 
    DT.95367331  DT.91685401  DT.99995308  DT.95367302  DT.100691120  DT.100691121  DT.97848018  DT.100691131 
    DT.121447550  DT.121447651  DT.92340564  DT.91943007  DT.65288701  DT.100691141  DT.100691153  DT.121447816 

    24/1523 AceView cDNA sequences (see all 1523):

    BM754685 BQ942866 W95813 AA604040 BQ959195 AL554738 CA397024 BQ049869 
    BM821894 F12362 CR596382 BM662494 CR592538 CD675606 CR613039 BM744803 
    BI335255 BE254159 CR622881 BQ007162 BG474081 BX439028 BM854263 BM763366 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ARF1 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d · 9e
    SP1:                          -     -     -     -     -     -                                                     -                                 
    SP2:                                -     -     -     -     -                                                     -                                 
    SP3:                          -     -     -     -     -     -           -     -     -                             -                                 
    SP4:                          -     -     -     -     -     -                                                                                       
    SP5:                          -     -     -     -     -     -                                                     -                                 


    ECgene alternative splicing isoforms for ARF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARF1 expression in normal human tissues (normalized intensities)      ARF1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTTGTCCC
    ARF1 Expression
    About this image


    ARF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/24 selected tissues (see all 24) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 2 entries
             salivary gland ; glandular cells   
             TONGUE   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   

    See ARF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARF1

    SOURCE GeneReport for Unigene cluster: Hs.286221
        SABiosciences Custom PCR Arrays for ARF1
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARF1 gene from 10/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arf15
    Arf21
    ADP-ribosylation factor 15
    ADP-ribosylation factor 21
    79.56(n)1
    95.58(a)1
      11 (37.05 cM)5
    118411  NM_007477.41  NP_031503.11 
     592114145 
    chicken
    (Gallus gallus)
    Aves ARF11 ADP-ribosylation factor 1 83.43(n)
    98.9(a)
      420398  NM_001006352.1  NP_001006352.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARF16
    Uncharacterized protein
    100(a)
    1 ↔ 1
    6(3287210-3306634)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044960.12   -- 84.64(n)    BC044960.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC044531.12   -- 81.62(n)    BC044531.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Arf79F1 , 3 protein amino acid ADP-ribosylation GTP
    binding3
    ADP ribosylation factor 79F1
    96(a)
    (best of 2)3
    77.84(n)1
    96.65(a)1
      80B23
    405061  NM_168973.31  NP_730760.11 
    worm
    (Caenorhabditis elegans)
    Secernentea arf-13
    arf-1.21
    ARF3
    Protein ARF-1.21
    93(a)
    (best of 6)3
    74.63(n)1
    93.89(a)1
      III(5787540-5788738)3
    1758011  NM_065834.21  NP_498235.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARF2(YDL137W)4
    ARF11
    ADP-ribosylation factor, GTPase of the Ras superfamily more4
    Arf1p1
    64.25(n)1
    77.65(a)1
      4(216529-217074)4
    8513351  NP_010089.11  8514184 
     NP_010144.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ARFA1B1 ADP-ribosylation factor A1B 74.95(n)
    89.83(a)
      831319  NM_121471.1  NP_196971.1 
    rice
    (Oryza sativa)
    Liliopsida AK065370.12   -- 79.55(n)    AK065370.1 


    ENSEMBL Gene Tree for ARF1 (if available)
    TreeFam Gene Tree for ARF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARF1 gene
    ARL4A2  ARF42  ARL112  ARF52  ARL142  ARL4D2  ARF32  ARF62  
    ARL4C2  ARL8A2  TRIM232  ARL8B2  
    18/30 SIMAP similar genes for ARF1 using alignment to 1 protein entry:     ARF1_HUMAN(see all similar genes):
    ARF3    ARL17A    ARL17B    ARF5    ARF4    ARF6
    ARL1    TRIM23    ARL14    ARL2    ARL5B    ARL5A
    ARL3    ARL6    ARL5C    ARL4D    ARL11    ARL4C

    ARF1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for ARF1
    PGOHUM00000239593 PGOHUM00000233475 PGOHUM00000249793


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/335 SNPs in ARF1 are shown (see all 335)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38206241,2
    C--228268492(+) ATTTTA/GTTACT 2 -- us2k15Minor allele frequency- G:0.06NA WA EA 362
    rs1811370481,2
    C--228268655(+) GAGTTC/TGAGAC 2 -- us2k10--------
    rs1862741351,2
    --228268812(+) CAAGAC/TTGTGT 2 -- us2k10--------
    rs1912261041,2
    --228268838(+) TGGGCA/GACAGA 2 -- us2k10--------
    rs37543551,2
    C,F--228268884(+) AAAGTA/GTTTTA 4 -- us2k11Minor allele frequency- G:0.01EA 120
    rs1419228421,2
    C--228268890(+) TTTTAA/GAGGAA 4 -- us2k10--------
    rs741409141,2
    C,F--228269040(+) TGTCCG/ACACAT 4 -- us2k11Minor allele frequency- A:0.50WA 2
    rs8227341,2
    C,F,H--228269089(-) TGGAAC/ACTTCT 4 -- us2k111Minor allele frequency- A:0.00NA EA NS 938
    rs1163105291,2
    C,F--228269101(+) AGGCAT/CCCACA 4 -- us2k11Minor allele frequency- C:0.05WA 118
    rs1863065501,2
    --228269381(+) TGATGA/GGGGCA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARF1 (228270361 - 228286913 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ARF1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv523935CNV Loss19592680
    nsv516409CNV Loss19592680
    nsv832803CNV Loss17160897
    dgv537n71CNV Loss21882294
    nsv873252CNV Loss21882294
    nsv873255CNV Loss21882294
    esv32853CNV Gain17666407
    nsv826908CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 103180    OMIM disorders: --

    16 diseases for ARF1:    About MalaCards
    rheumatic myocarditis    cholera    tangier disease    vesiculitis
    myocarditis    gout    malaria    retinoblastoma
    hepatitis c    pancreatic cancer    endotheliitis    hepatitis
    gastric cancer    pancreatitis    breast cancer    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for ARF1:
    Cholera     Rheumatic myocarditis

    ARF1 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for ARF1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholera 50.2 13 7814376 (3), 8144566 (2), 7961931 (2), 1577740 (1) (see all 5)
    tumors 0.824 3 17367606 (1), 15946480 (1)
    cancer 0.628 1 18990689 (1)

    Genetic Association Database (GAD): ARF1
    Human Genome Epidemiology (HuGE) Navigator: ARF1 (3 documents)

    Export disorders for ARF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARF1 gene, integrated from 9 sources (see all 360):
    (articles sorted by number of sources associating them with ARF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human gene encoding ADP-ribosylation factor 1, a guanine nucleotide-binding activator of cholera toxin. (PubMed id 1577740)1, 2, 3, 9 Lee C.M.... Vaughan M. (1992)
    2. p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins. (PubMed id 8861955)1, 2, 9 Rosa J.L.... Barbacid M. (1996)
    3. Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes. (PubMed id 17347647)1, 2, 9 Menetrey J.... Houdusse A. (2007)
    4. Structure of the human ADP-ribosylation factor 1 complexed with GDP. (PubMed id 7990966)1, 2, 9 Amor J.C.... Ringe D. (1994)
    5. Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III beta. (PubMed id 17555535)1, 2, 9 Haynes L.P.... Burgoyne R.D. (2007)
    6. Structural and functional analysis of the ARF1-ARFGAP complex reveals a role for coatomer in GTP hydrolysis. (PubMed id 10102276)1, 2, 9 Goldberg J. (1999)
    7. Human ADP-ribosylation factors. A functionally conserved family of GTP-binding proteins. (PubMed id 1899243)1, 2, 9 Kahn R.A.... Rulka C. (1991)
    8. Molecular basis of phosphatidylinositol 4-phosphate a nd ARF1 GTPase recognition by the FAPP1 pleckstrin homology (PH) domain. (PubMed id 21454700)1, 2 He J....Kutateladze T.G. (2011)
    9. Association of genetic polymorphisms in GADD45A, MDM2 , and p14 ARF with the risk of chronic benzene poisoning in a Chinese occupatio nal population. (PubMed id 19596022)1, 4 Sun P....Xia Z. (2009)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 375 HGNC: 652 AceView: ARF1 Ensembl:ENSG00000143761 euGenes: HUgn375
    ECgene: ARF1 Kegg: 375 H-InvDB: ARF1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARF1 gene:
    Search GeneIP for patents involving ARF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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