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ARF1 Gene

protein-coding   GIFtS: 70
GCID: GC01P228270

ADP-Ribosylation Factor 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADP-Ribosylation Factor 11 2

External Ids:    HGNC: 6521   Entrez Gene: 3752   Ensembl: ENSG000001437617   OMIM: 1031805   UniProtKB: P840773   

Export aliases for ARF1 gene to outside databases

Previous GC identifers: GC01P226767 GC01P224008 GC01P224655 GC01P225244 GC01P224577 GC01P226336 GC01P198785


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARF1 Gene:
ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine
nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role
in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11
ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1,
ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene
organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi
transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this
gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for ARF1 Gene:
ARF1 (ADP-ribosylation factor 1) is a protein-coding gene. Diseases associated with ARF1 include rheumatic myocarditis, and cholera. GO annotations related to this gene include receptor signaling protein activity and GTP binding. An important paralog of this gene is ARL2.

UniProtKB/Swiss-Prot: ARF1_HUMAN, P84077
Function: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an
ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding
and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to
the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers
the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated
by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The
GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function
is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine
shrinkage during long-term depression (LTD)

Gene Wiki entry for ARF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARF1 gene promoter:
         FOXF2   ATF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARF1 promoter sequence
   Search Chromatin IP Primers for ARF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42   Ensembl cytogenetic band:  1q42.13   HGNC cytogenetic band: 1q42.13

ARF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARF1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P228270:  view genomic region     (about GC identifiers)

Start:
228,270,361 bp from pter      End:
228,286,913 bp from pter
Size:
16,553 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARF1_HUMAN, P84077 (See protein sequence)
Recommended Name: ADP-ribosylation factor 1  
Size: 181 amino acids; 20697 Da
Subunit: Interacts with ARHGAP21, ASAP2, GGA1, HERC1, PRKCABP, PIP5K1B, TMED2, PSCD2, TMED10 and GRIA2. Interacts
with ARFGAP1, which hydrolyzes GTP and thus, regulates its function. Interacts with PI4KB in the Golgi complex.
Interacts with NCS1/FREQ in the Golgi and at the plasma membrane. Interacts with PLEKHA3. Interacts with PLEKHA8;
the interaction, together with phosphatidylinositol 4-phosphate binding, is required for FAPP2-mediated
glucosylceramide transfer activity. Interacts (activated) with PICK1 (via PDZ domain); the interaction blocks
Arp2/3 complex inhibition
5 PDB 3D structures from and Proteopedia for ARF1:
1HUR (3D)        1RE0 (3D)        1U81 (3D)        3O47 (3D)        4HMY (3D)    
Secondary accessions: P10947 P32889

Explore the universe of human proteins at neXtProt for ARF1: NX_P84077

Explore proteomics data for ARF1 at MOPED

Post-translational modifications: 

  • Demyristoylated by S.flexneri cysteine protease IpaJ which cleaves the peptide bond between N-myristoylated Gly-2
    and Asn-31
  • Ubiquitination2 at Lys73, Lys127, Lys142
  • Modification sites at PhosphoSitePlus

  • See ARF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001019397.1  NP_001019398.1  NP_001019399.1  NP_001649.1  

    ENSEMBL proteins: 
     ENSP00000272102   ENSP00000442980   ENSP00000440005  
    Reactome Protein details: P84077

    ARF1 Human Recombinant Protein Products:

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    ARF1 Antibody Products:

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    Abcam antibodies for ARF1 (P61204, P32889, P84077)
    Cloud-Clone Corp. Antibodies for ARF1
    ThermoFisher Antibody for ARF1
    LSBio Antibodies in human, mouse, rat for ARF1

    ARF1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ARF1
    Cloud-Clone Corp. CLIAs for ARF1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    ARF: ADP-ribosylation factors

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR027417 P-loop_NTPase
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF

    Graphical View of Domain Structure for InterPro Entry P84077

    ProtoNet protein and cluster: P84077

    UniProtKB/Swiss-Prot: ARF1_HUMAN, P84077
    Similarity: Belongs to the small GTPase superfamily. Arf family


    ARF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARF1_HUMAN, P84077
    Function: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an
    ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding
    and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to
    the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers
    the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated
    by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The
    GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function
    is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine
    shrinkage during long-term depression (LTD)

         Genatlas biochemistry entry for ARF1:
    ADP ribosylation factor 1,class I,low molecular weight GTP binding protein (20kDa),widely expressed,a guanine
    nucleotide dependent protein activator of cholera toxin,Ras superfamily member,involved in the coating of
    vesicles that bud from Golgi compartments and vesicular trafficking,through interaction with ARF exchange factor
    such as cytohesin- 1 (PSCD1),ARNO (PSCD2),PSCD2L

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS1577740
    GO:0004871signal transducer activity ----
    GO:0005057receptor signaling protein activity TAS8529647
    GO:0005515protein binding IPI10198630
    GO:0005525GTP binding IEA--
         
    ARF1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ARF1:
     Decreased Salmonella enterica   Decreased p24 protein expressi  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARF1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARF1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARF1

    miRNA
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    miRTarBase miRNAs that target ARF1:
    hsa-mir-92a-3p (MIRT049435), hsa-mir-324-5p (MIRT043175), hsa-mir-615-3p (MIRT040063), hsa-mir-320b (MIRT036212), hsa-mir-30b-5p (MIRT046160), hsa-mir-30c-5p (MIRT047891), hsa-mir-296-3p (MIRT038364)

    Block miRNA regulation of human, mouse, rat ARF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARF1 (see all 34):
    hsa-miR-124* hsa-miR-219-1-3p hsa-miR-323-3p hsa-miR-520f hsa-miR-25 hsa-miR-624* hsa-miR-766 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidARF1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARF1

    Gene Editing
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    Clone
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    Sino Biological Human cDNA Clone for ARF1
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARF1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARF1_HUMAN, P84077: Golgi apparatus. Cytoplasm, perinuclear region. Cell junction, synapse, synaptosome (By
    similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol4
    plasma membrane4
    cytoskeleton2
    endoplasmic reticulum2
    endosome2
    mitochondrion2
    extracellular1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus ----

    ARF1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARF1 About   (see all 22)  
    See pathways by source

    SuperPathContained pathways About
    1COPI Mediated Transport
    COPI Mediated Transport0.31
    Golgi to ER Retrograde Transport0.00
    Cholesterol and Sphingolipids transport Transport from Golgi and ER to the apical membrane normal and CF 0.31
    2Clathrin dependent protein traffic
    Clathrin dependent protein traffic0.66
    Transport Clathrin coated vesicle cycle0.66
    3Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    Lysosome Vesicle Biogenesis0.41
    Golgi Associated Vesicle Biogenesis0.89
    Membrane Trafficking0.32
    trans-Golgi Network Vesicle Budding0.89
    4Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
    Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters0.76
    Nef Mediated CD4 Down-regulation0.00
    The role of Nef in HIV-1 replication and disease pathogenesis0.76
    5PI Metabolism
    PI Metabolism0.65
    Synthesis of PIPs at the Golgi membrane0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ARF1
        Cholera Infection
    Paxillin Interactions

    3 GeneGo (Thomson Reuters) Pathways for ARF1
        Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)
    Transport Clathrin-coated vesicle cycle
    Cytoskeleton remodeling RalA regulation pathway

    Selected BioSystems Pathways for ARF1 (see all 6)
        Cell cycle
    Insulin Signaling
    Integrated Pancreatic Cancer Pathway
    Arf1 pathway
    Arf6 downstream pathway


    Selected Reactome Pathways for ARF1 (see all 7)
        Clathrin derived vesicle budding
    Golgi Associated Vesicle Biogenesis
    COPI Mediated Transport
    Lysosome Vesicle Biogenesis
    MHC class II antigen presentation


    2 Kegg Pathways  (Kegg details for ARF1):
        Vibrio cholerae infection
    Legionellosis


    ARF1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARF1
    Interactions:

        GeneGlobe Interaction Network for ARF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARF1 (P840771, 2, 3 ENSP000002721024) via UniProtKB, MINT, STRING, and/or I2D (see all 181)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPAG9O602711, 2, 3, ENSP000002620134EBI-447171,EBI-1023301 MINT-7922576 MINT-7922541 MINT-7922558 I2D: score=1 STRING: ENSP00000262013
    ASAP1Q9ULH12, 3, ENSP000003502974MINT-68737 MINT-68738 I2D: score=2 STRING: ENSP00000350297
    WBP11Q9Y2W22, 3, ENSP000002611674MINT-64019 I2D: score=4 STRING: ENSP00000261167
    CYTH2Q994181, 3, ENSP000004082364EBI-447171,EBI-448974 I2D: score=3 STRING: ENSP00000408236
    MYCP011062, 3, ENSP000003672074MINT-4648256 I2D: score=1 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002090regulation of receptor internalization ISS--
    GO:0006184GTP catabolic process TAS1577740
    GO:0006644phospholipid metabolic process TAS--
    GO:0006661phosphatidylinositol biosynthetic process TAS--
    GO:0006878cellular copper ion homeostasis IMP--

    ARF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARF1

    1 HMDB Compound for ARF1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    7 DrugBank Compounds for ARF1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1,3-Propandiol-- --target--17139284 17016423 10592235
    Glycerol-- --target--17139284 17016423 10592235
    Guanosine-3'-Monophosphate-5'-Diphosphate-- --target--17139284 17016423 10592235
    Guanosine-5'-Diphosphate-- 146-91-8target--17139284 17016423 10592235
    Guanosine-5'-Triphosphate-- 86-01-1target--17139284 17016423 10592235
    1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE-- --target--10592235
    MYRISTIC ACID-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for ARF1 gene (see all 25)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 83.5 97 9614177 (6), 8106346 (4), 14654841 (4), 19015319 (3) (see all 45)
    gdp 77.5 29 14690595 (2), 7990966 (2), 9649435 (2), 10954741 (2) (see all 16)
    grp-1 75.9 1 10480924 (1)
    adp 69.5 56 10377261 (2), 11726511 (2), 12885418 (2), 15814706 (2) (see all 36)
    guanosine 5'-o-(3-thiotriphosphate) 67.7 7 9346296 (2), 9539714 (1), 10212218 (1), 9614177 (1) (see all 5)
    ptdins(3)p 58.5 4 10657240 (1), 20231409 (1)
    pip2 50.4 8 9065426 (3), 9268368 (2), 8793299 (1)
    c2ceramide 49.9 2 8995404 (1), 14615385 (1)
    phosphatidate 48 1 8793299 (1)
    phosphatidylinositol 46.9 10 11927660 (2), 18990689 (2), 16246097 (1), 11931656 (1) (see all 6)



    ARF1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARF1 gene (4 alternative transcripts): 
    NM_001024226.1  NM_001024227.1  NM_001024228.1  NM_001658.3  

    Unigene Cluster for ARF1:

    ADP-ribosylation factor 1
    Hs.286221  [show with all ESTs]
    Unigene Representative Sequence: AK023803
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000272102 ENST00000477821 ENST00000470670 ENST00000478424 ENST00000470558
    ENST00000473949 ENST00000477451 ENST00000478336 ENST00000469235 ENST00000473546
    ENST00000482962 ENST00000497165 ENST00000490705 ENST00000540651(uc001hrs.3 uc001hrr.3)
    ENST00000541182(uc001hru.3 uc001hrv.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ARF1 (see all 34):
    hsa-miR-124* hsa-miR-219-1-3p hsa-miR-323-3p hsa-miR-520f hsa-miR-25 hsa-miR-624* hsa-miR-766 hsa-miR-570
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    GenScript: all cDNA clones in your preferred vector (see all 4): ARF1 (NM_001024226)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARF1
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      QuantiTect SYBR Green Assays in human, mouse, rat ARF1
      QuantiFast Probe-based Assays in human, mouse, rat ARF1

    Additional mRNA sequence: 

    AF052179.1 AF055002.1 AF493881.1 AK000620.1 AK023803.1 AK057838.1 AK057875.1 AK130737.1 
    AK293553.1 AK296020.1 AK297792.1 BC009247.2 BC010415.2 BC010429.1 BC011358.1 BT007393.1 
    M36340.1 M84326.1 

    Selected DOTS entries (see all 70):

    DT.97848008  DT.100691142  DT.100857717  DT.91782057  DT.100691127  DT.100691167  DT.95367313  DT.100865197 
    DT.95367331  DT.91685401  DT.99995308  DT.95367302  DT.100691120  DT.100691121  DT.97848018  DT.100691131 
    DT.121447550  DT.121447651  DT.92340564  DT.91943007  DT.65288701  DT.100691141  DT.100691153  DT.121447816 

    Selected AceView cDNA sequences (see all 1523):

    BU730537 AL531901 BM461397 AA922506 BQ669352 BM046985 BM450182 AW245282 
    CA868532 BF794014 BM662351 BM744803 BQ953611 BQ430212 AL517415 AA627488 
    AL547872 M84326 BM748395 CR611972 CR609483 BM927920 CR618870 BE277751 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARF1 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d · 9e
    SP1:                          -     -     -     -     -     -                                                     -                                 
    SP2:                                -     -     -     -     -                                                     -                                 
    SP3:                          -     -     -     -     -     -           -     -     -                             -                                 
    SP4:                          -     -     -     -     -     -                                                                                       
    SP5:                          -     -     -     -     -     -                                                     -                                 


    ECgene alternative splicing isoforms for ARF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTTGTCCC
    ARF1 Expression
    About this image


    ARF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    ARF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.286221
        Custom PCR Arrays for ARF1
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARF1 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arf11 , 5 ADP-ribosylation factor 11, 5 91.9(n)1
    100(a)1
      11 (37.05 cM)5
    118401  NM_007476.31  NP_031502.11 
     592114145 
    chicken
    (Gallus gallus)
    Aves ARF11 ADP-ribosylation factor 1 83.43(n)
    98.9(a)
      420398  NM_001006352.1  NP_001006352.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARF16
    ADP-ribosylation factor 1
    100(a)
    1 ↔ 1
    6(3287210-3306634)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044960.12   -- 84.64(n)    BC044960.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC044531.12   -- 81.62(n)    BC044531.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Arf79F1 , 3 protein amino acid ADP-ribosylation GTP
    binding3
    ADP ribosylation factor 79F1
    96(a)
    (best of 2)3
    77.84(n)1
    96.65(a)1
      80B23
    405061  NM_168973.31  NP_730760.11 
    worm
    (Caenorhabditis elegans)
    Secernentea arf-13
    arf-1.21
    ARF3
    arf-1.21
    93(a)
    (best of 6)3
    74.63(n)1
    93.89(a)1
      III(5787540-5788738)3
    1758011  NM_065834.31  NP_498235.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARF2(YDL137W)4 ADP-ribosylation factor, GTPase of the Ras superfamily more   --   4(216529-217074) 851418  NP_010144.1 
    rice
    (Oryza sativa)
    Liliopsida AK065370.12   -- 79.55(n)    AK065370.1 


    ENSEMBL Gene Tree for ARF1 (if available)
    TreeFam Gene Tree for ARF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARF1 gene
    ARL22  ARL5B2  ENSG000002730032  ARL5C2  ARF42  ENSG000002728222  ARF52  ARL32  
    ARL5A2  ARF32  ARF62  TRIM232  
    Selected SIMAP similar genes for ARF1 using alignment to 1 protein entry:     ARF1_HUMAN(see all similar genes):
    ARF3    ARL17A    ARL17B    ARF5    ARF4    ARF6
    ARL1    TRIM23    ARL14    ARL2    ARL5B    ARL5A
    ARL3    ARL6    ARL5C    ARL4D    ARL11    ARL4C

    ARF1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for ARF1
    PGOHUM00000239593 PGOHUM00000233475 PGOHUM00000249793


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARF1 (see all 335)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38206241,2
    C--228268492(+) ATTTTA/GTTACT 2 -- us2k15Minor allele frequency- G:0.06NA WA EA 362
    rs1811370481,2
    C--228268655(+) GAGTTC/TGAGAC 2 -- us2k10--------
    rs1862741351,2
    --228268812(+) CAAGAC/TTGTGT 2 -- us2k10--------
    rs1912261041,2
    --228268838(+) TGGGCA/GACAGA 2 -- us2k10--------
    rs37543551,2
    C,F--228268884(+) AAAGTA/GTTTTA 4 -- us2k11Minor allele frequency- G:0.01EA 120
    rs1419228421,2
    C--228268890(+) TTTTAA/GAGGAA 4 -- us2k10--------
    rs741409141,2
    C,F--228269040(+) TGTCCG/ACACAT 4 -- us2k11Minor allele frequency- A:0.50WA 2
    rs8227341,2
    C,F,H--228269089(-) TGGAAC/ACTTCT 4 -- us2k111Minor allele frequency- A:0.00NA EA NS 938
    rs1163105291,2
    C,F--228269101(+) AGGCAT/CCCACA 4 -- us2k11Minor allele frequency- C:0.05WA 118
    rs1863065501,2
    --228269381(+) TGATGA/GGGGCA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARF1 (228270361 - 228286913 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ARF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv523935CNV Loss19592680
    nsv516409CNV Loss19592680
    nsv832803CNV Loss17160897
    dgv537n71CNV Loss21882294
    nsv873252CNV Loss21882294
    nsv873255CNV Loss21882294
    esv32853CNV Gain17666407
    nsv826908CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 103180    OMIM disorders: --

    Selected diseases for ARF1 (see all 23):    
    About MalaCards
    rheumatic myocarditis    cholera    tangier disease    vesiculitis
    legionellosis    myocarditis    gout    malaria
    hepatitis c virus    retinoblastoma    hepatitis c    pancreatic cancer
    hiv-1    pancreatitis    tonsillitis    hepatitis
    endotheliitis    alzheimer's disease    breast cancer    thyroiditis

    2 diseases from the University of Copenhagen DISEASES database for ARF1:
    Cholera     Rheumatic myocarditis

    ARF1 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for ARF1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholera 50.2 13 7814376 (3), 8144566 (2), 7961931 (2), 1577740 (1) (see all 5)
    tumors 0.824 3 17367606 (1), 15946480 (1)
    cancer 0.628 1 18990689 (1)

    Genetic Association Database (GAD): ARF1
    Human Genome Epidemiology (HuGE) Navigator: ARF1 (3 documents)

    Export disorders for ARF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARF1 gene, integrated from 10 sources (see all 369):
    (articles sorted by number of sources associating them with ARF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human gene encoding ADP-ribosylation factor 1, a guanine nucleotide-binding activator of cholera toxin. (PubMed id 1577740)1, 2, 3, 9 Lee C.M.... Vaughan M. (J. Biol. Chem. 1992)
    2. p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins. (PubMed id 8861955)1, 2, 9 Rosa J.L.... Barbacid M. (EMBO J. 1996)
    3. Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes. (PubMed id 17347647)1, 2, 9 Menetrey J.... Houdusse A. (EMBO J. 2007)
    4. Structure of the human ADP-ribosylation factor 1 complexed with GDP. (PubMed id 7990966)1, 2, 9 Amor J.C.... Ringe D. (Nature 1994)
    5. Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III beta. (PubMed id 17555535)1, 2, 9 Haynes L.P.... Burgoyne R.D. (Traffic 2007)
    6. Structural and functional analysis of the ARF1-ARFGAP complex reveals a role for coatomer in GTP hydrolysis. (PubMed id 10102276)1, 2, 9 Goldberg J. (Cell 1999)
    7. Human ADP-ribosylation factors. A functionally conserved family of GTP-binding proteins. (PubMed id 1899243)1, 2, 9 Kahn R.A.... Rulka C. (J. Biol. Chem. 1991)
    8. Molecular basis of phosphatidylinositol 4-phosphate and ARF1 GTPase recognition by the FAPP1 pleckstrin homology (PH) domain. (PubMed id 21454700)1, 2 He J.... Kutateladze T.G. (J. Biol. Chem. 2011)
    9. Association of genetic polymorphisms in GADD45A, MDM2, and p14 ARF with the risk of chronic benzene poisoning in a Chinese occupational population. (PubMed id 19596022)1, 4 Sun P....Xia Z. (Toxicol. Appl. Pharmacol. 2009)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 375 HGNC: 652 AceView: ARF1 Ensembl:ENSG00000143761 euGenes: HUgn375
    ECgene: ARF1 Kegg: 375 H-InvDB: ARF1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ARF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ARF1 gene:
    Search GeneIP for patents involving ARF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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