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Aliases for ARF1 Gene

Aliases for ARF1 Gene

  • ADP Ribosylation Factor 1 2 3 5

External Ids for ARF1 Gene

Previous GeneCards Identifiers for ARF1 Gene

  • GC01P226767
  • GC01P224008
  • GC01P224655
  • GC01P225244
  • GC01P224577
  • GC01P226336
  • GC01P228270
  • GC01P198785

Summaries for ARF1 Gene

Entrez Gene Summary for ARF1 Gene

  • ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARF1 Gene

ARF1 (ADP Ribosylation Factor 1) is a Protein Coding gene. Diseases associated with ARF1 include Cholera and Rheumatic Myocarditis. Among its related pathways are Clathrin derived vesicle budding and PI Metabolism. GO annotations related to this gene include poly(A) RNA binding and GTPase activity. An important paralog of this gene is ARF3.

UniProtKB/Swiss-Prot for ARF1 Gene

  • GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).

Gene Wiki entry for ARF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARF1 Gene

Genomics for ARF1 Gene

Regulatory Elements for ARF1 Gene

Enhancers for ARF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ARF1 on UCSC Golden Path with GeneCards custom track

Promoters for ARF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARF1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ARF1 gene promoter:

Genomic Location for ARF1 Gene

Chromosome:
1
Start:
228,082,660 bp from pter
End:
228,099,212 bp from pter
Size:
16,553 bases
Orientation:
Plus strand

Genomic View for ARF1 Gene

Genes around ARF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARF1 Gene

Proteins for ARF1 Gene

  • Protein details for ARF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P84077-ARF1_HUMAN
    Recommended name:
    ADP-ribosylation factor 1
    Protein Accession:
    P84077
    Secondary Accessions:
    • P10947
    • P32889

    Protein attributes for ARF1 Gene

    Size:
    181 amino acids
    Molecular mass:
    20697 Da
    Quaternary structure:
    • Interacts with ARHGAP21, ASAP2, GGA1, HERC1, PRKCABP, PIP5K1B, TMED2, PSCD2, TMED10 and GRIA2. Interacts with ARFGAP1, which hydrolyzes GTP and thus, regulates its function. Interacts with PI4KB in the Golgi complex. Interacts with NCS1/FREQ in the Golgi and at the plasma membrane. Interacts with PLEKHA3. Interacts with PLEKHA8; the interaction, together with phosphatidylinositol 4-phosphate binding, is required for FAPP2-mediated glucosylceramide transfer activity. Interacts (activated) with PICK1 (via PDZ domain); the interaction blocks Arp2/3 complex inhibition. Interacts with IQSEC1 (PubMed:24058294).
    • Interacts with ARHGAP21, ASAP2, GGA1, HERC1, PRKCABP, PIP5K1B, TMED2, PSCD2, TMED10 and GRIA2. Interacts with ARFGAP1, which hydrolyzes GTP and thus, regulates its function. Interacts with PI4KB in the Golgi complex. Interacts with NCS1/FREQ in the Golgi and at the plasma membrane. Interacts with PLEKHA3. Interacts with PLEKHA8; the interaction, together with phosphatidylinositol 4-phosphate binding, is required for FAPP2-mediated glucosylceramide transfer activity. Interacts (activated) with PICK1 (via PDZ domain); the interaction blocks Arp2/3 complex inhibition. Interacts with IQSEC1 (PubMed:24058294).

    Three dimensional structures from OCA and Proteopedia for ARF1 Gene

neXtProt entry for ARF1 Gene

Post-translational modifications for ARF1 Gene

  • Demyristoylated by S.flexneri cysteine protease IpaJ which cleaves the peptide bond between N-myristoylated Gly-2 and Asn-3.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARF1 Gene

No data available for DME Specific Peptides for ARF1 Gene

Domains & Families for ARF1 Gene

Gene Families for ARF1 Gene

Protein Domains for ARF1 Gene

Suggested Antigen Peptide Sequences for ARF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P84077

UniProtKB/Swiss-Prot:

ARF1_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARF1: view

Function for ARF1 Gene

Molecular function for ARF1 Gene

GENATLAS Biochemistry:
ADP ribosylation factor 1,class I,low molecular weight GTP binding protein (20kDa),widely expressed,a guanine nucleotide dependent protein activator of cholera toxin,Ras superfamily member,involved in the coating of vesicles that bud from Golgi compartments and vesicular trafficking,through interaction with ARF exchange factor such as cytohesin- 1 (PSCD1),ARNO (PSCD2),PSCD2L
UniProtKB/Swiss-Prot Function:
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).

Gene Ontology (GO) - Molecular Function for ARF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0003924 GTPase activity TAS --
GO:0005057 receptor signaling protein activity TAS 8529647
GO:0005515 protein binding IEA,IPI 10198630
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with ARF1: view
genes like me logo Genes that share phenotypes with ARF1: view

Animal Models for ARF1 Gene

MGI Knock Outs for ARF1:

Animal Model Products

CRISPR Products

miRNA for ARF1 Gene

miRTarBase miRNAs that target ARF1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARF1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARF1 Gene

Localization for ARF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARF1 Gene

Golgi apparatus. Cytoplasm, perinuclear region. Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARF1 Gene COMPARTMENTS Subcellular localization image for ARF1 gene
Compartment Confidence
cytosol 5
endosome 5
extracellular 5
golgi apparatus 5
plasma membrane 5
cytoskeleton 2
endoplasmic reticulum 2
mitochondrion 2
peroxisome 2
vacuole 2
lysosome 1

Gene Ontology (GO) - Cellular Components for ARF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005770 late endosome IEA --
GO:0005778 peroxisomal membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005802 trans-Golgi network IEA --
genes like me logo Genes that share ontologies with ARF1: view

Pathways & Interactions for ARF1 Gene

genes like me logo Genes that share pathways with ARF1: view

Gene Ontology (GO) - Biological Process for ARF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002090 regulation of receptor internalization IEA,ISS --
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0006878 cellular copper ion homeostasis IMP 21034850
GO:0006892 post-Golgi vesicle-mediated transport TAS --
GO:0007015 actin filament organization IEA --
genes like me logo Genes that share ontologies with ARF1: view

No data available for SIGNOR curated interactions for ARF1 Gene

Drugs & Compounds for ARF1 Gene

(13) Drugs for ARF1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycerol Approved, Experimental Pharma Target 210
Guanosine triphosphate Experimental Pharma Target 0
1,3-Propandiol Experimental Pharma Target 0
1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE Experimental Pharma Target 0
Guanosine diphosphate Experimental Pharma Target 0

(19) Additional Compounds for ARF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ARF1: view

Transcripts for ARF1 Gene

Unigene Clusters for ARF1 Gene

ADP-ribosylation factor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARF1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARF1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: -
SP7: - - - - - - - - - - -
SP8:
SP9: - - - - - -
SP10: - -
SP11: - - -

Relevant External Links for ARF1 Gene

GeneLoc Exon Structure for
ARF1
ECgene alternative splicing isoforms for
ARF1

Expression for ARF1 Gene

mRNA expression in normal human tissues for ARF1 Gene

Protein differential expression in normal tissues from HIPED for ARF1 Gene

This gene is overexpressed in Blymphocyte (11.7), Tlymphocyte (10.9), Nasal epithelium (6.4), and Cervix (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARF1 Gene



Protein tissue co-expression partners for ARF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARF1 Gene:

ARF1

SOURCE GeneReport for Unigene cluster for ARF1 Gene:

Hs.286221
genes like me logo Genes that share expression patterns with ARF1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARF1 Gene

Orthologs for ARF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARF1 34
  • 90.79 (n)
  • 100 (a)
ARF1 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC607365 34
  • 93 (n)
  • 100 (a)
ARF1 35
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arf1 34
  • 91.9 (n)
  • 100 (a)
Arf1 16
Arf1 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC457177 34
  • 99.63 (n)
  • 100 (a)
ARF1 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arf1 34
  • 91.34 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia ARF1 35
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 67 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ARF1 34
  • 83.43 (n)
  • 98.9 (a)
ARF1 35
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARF1 35
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arf5 34
  • 81.03 (n)
  • 98.9 (a)
MGC76046 34
zebrafish
(Danio rerio)
Actinopterygii arf1 34
  • 81.67 (n)
  • 98.33 (a)
arf2 35
  • 97 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Arf102F 36
  • 82 (a)
Arf79F 36
  • 96 (a)
Arf79F 34
  • 77.84 (n)
  • 96.65 (a)
Arf79F 35
  • 95 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012014 34
  • 79.89 (n)
  • 96.65 (a)
worm
(Caenorhabditis elegans)
Secernentea arf-1 36
  • 93 (a)
arf-3 36
  • 85 (a)
arl-1 36
  • 58 (a)
arl-5 36
  • 48 (a)
arl-6 36
  • 61 (a)
arl-query 36
  • 41 (a)
arf-1.2 34
  • 74.63 (n)
  • 93.89 (a)
arf-1.2 35
  • 93 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARF1 35
  • 77 (a)
ManyToMany
ARF2 35
  • 77 (a)
ManyToMany
ARF2 37
corn
(Zea mays)
Liliopsida Zm.6331 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15067 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11304 35
  • 82 (a)
ManyToMany
Species where no ortholog for ARF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARF1 Gene

ENSEMBL:
Gene Tree for ARF1 (if available)
TreeFam:
Gene Tree for ARF1 (if available)

Paralogs for ARF1 Gene

Pseudogenes.org Pseudogenes for ARF1 Gene

genes like me logo Genes that share paralogs with ARF1: view

Variants for ARF1 Gene

Sequence variations from dbSNP and Humsavar for ARF1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs6920 -- 228,098,619(+) CTTGT(C/T)CTTGG utr-variant-3-prime
rs13338 -- 228,098,981(+) CCATC(A/G/T)AAAAA utr-variant-3-prime
rs14892 -- 228,098,947(+) CTTTC(C/T)CTCCC utr-variant-3-prime
rs708125 -- 228,091,219(-) AGGTG(A/G)TATCT intron-variant
rs822725 -- 228,095,176(-) CAGAA(G/T)ACTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARF1 Gene

Variant ID Type Subtype PubMed ID
esv32853 CNV gain 17666407
nsv1160102 CNV deletion 26073780
nsv516409 CNV loss 19592680
nsv523935 CNV loss 19592680
nsv826908 CNV gain 20364138
nsv832803 CNV loss 17160897
nsv952136 CNV deletion 24416366

Variation tolerance for ARF1 Gene

Residual Variation Intolerance Score: 38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARF1 Gene

Disorders for ARF1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ARF1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cholera
  • cholera - vibrio cholerae
rheumatic myocarditis
  • active rheumatic fever with myocarditis
- elite association - COSMIC cancer census association via MalaCards
Search ARF1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ARF1

Genetic Association Database (GAD)
ARF1
Human Genome Epidemiology (HuGE) Navigator
ARF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARF1
genes like me logo Genes that share disorders with ARF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARF1 Gene

Publications for ARF1 Gene

  1. Characterization of the human gene encoding ADP-ribosylation factor 1, a guanine nucleotide-binding activator of cholera toxin. (PMID: 1577740) Lee C.M. … Vaughan M. (J. Biol. Chem. 1992) 2 3 4 22 65
  2. Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes. (PMID: 17347647) Menetrey J. … Houdusse A. (EMBO J. 2007) 3 4 22 65
  3. Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism. (PMID: 14690595) Mossessova E. … Goldberg J. (Mol. Cell 2003) 3 4 22 65
  4. Structural and functional analysis of the ARF1-ARFGAP complex reveals a role for coatomer in GTP hydrolysis. (PMID: 10102276) Goldberg J. (Cell 1999) 3 4 22 65
  5. p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins. (PMID: 8861955) Rosa J.L. … Barbacid M. (EMBO J. 1996) 3 4 22 65

Products for ARF1 Gene

  • Addgene plasmids for ARF1

Sources for ARF1 Gene

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