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Aliases for ARF1 Gene

Aliases for ARF1 Gene

  • ADP Ribosylation Factor 1 2 3 5

External Ids for ARF1 Gene

Previous GeneCards Identifiers for ARF1 Gene

  • GC01P226767
  • GC01P224008
  • GC01P224655
  • GC01P225244
  • GC01P224577
  • GC01P226336
  • GC01P228270
  • GC01P198785

Summaries for ARF1 Gene

Entrez Gene Summary for ARF1 Gene

  • ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARF1 Gene

ARF1 (ADP Ribosylation Factor 1) is a Protein Coding gene. Diseases associated with ARF1 include cholera and rheumatic myocarditis. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and GTPase activity. An important paralog of this gene is ENSG00000272822.

UniProtKB/Swiss-Prot for ARF1 Gene

  • GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).

Gene Wiki entry for ARF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARF1 Gene

Genomics for ARF1 Gene

Regulatory Elements for ARF1 Gene

Promoters for ARF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARF1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ARF1 gene promoter:

Genomic Location for ARF1 Gene

Chromosome:
1
Start:
228,082,660 bp from pter
End:
228,099,212 bp from pter
Size:
16,553 bases
Orientation:
Plus strand

Genomic View for ARF1 Gene

Genes around ARF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARF1 Gene

Proteins for ARF1 Gene

  • Protein details for ARF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P84077-ARF1_HUMAN
    Recommended name:
    ADP-ribosylation factor 1
    Protein Accession:
    P84077
    Secondary Accessions:
    • P10947
    • P32889

    Protein attributes for ARF1 Gene

    Size:
    181 amino acids
    Molecular mass:
    20697 Da
    Quaternary structure:
    • Interacts with ARHGAP21, ASAP2, GGA1, HERC1, PRKCABP, PIP5K1B, TMED2, PSCD2, TMED10 and GRIA2. Interacts with ARFGAP1, which hydrolyzes GTP and thus, regulates its function. Interacts with PI4KB in the Golgi complex. Interacts with NCS1/FREQ in the Golgi and at the plasma membrane. Interacts with PLEKHA3. Interacts with PLEKHA8; the interaction, together with phosphatidylinositol 4-phosphate binding, is required for FAPP2-mediated glucosylceramide transfer activity. Interacts (activated) with PICK1 (via PDZ domain); the interaction blocks Arp2/3 complex inhibition. Interacts with IQSEC1 (PubMed:24058294).

    Three dimensional structures from OCA and Proteopedia for ARF1 Gene

neXtProt entry for ARF1 Gene

Proteomics data for ARF1 Gene at MOPED

Post-translational modifications for ARF1 Gene

  • Demyristoylated by S.flexneri cysteine protease IpaJ which cleaves the peptide bond between N-myristoylated Gly-2 and Asn-3.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARF1 Gene

Antibody Products

No data available for DME Specific Peptides for ARF1 Gene

Domains & Families for ARF1 Gene

Gene Families for ARF1 Gene

Protein Domains for ARF1 Gene

Suggested Antigen Peptide Sequences for ARF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P84077

UniProtKB/Swiss-Prot:

ARF1_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARF1: view

Function for ARF1 Gene

Molecular function for ARF1 Gene

GENATLAS Biochemistry:
ADP ribosylation factor 1,class I,low molecular weight GTP binding protein (20kDa),widely expressed,a guanine nucleotide dependent protein activator of cholera toxin,Ras superfamily member,involved in the coating of vesicles that bud from Golgi compartments and vesicular trafficking,through interaction with ARF exchange factor such as cytohesin- 1 (PSCD1),ARNO (PSCD2),PSCD2L
UniProtKB/Swiss-Prot Function:
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).

Gene Ontology (GO) - Molecular Function for ARF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1990583 phospholipase D activator activity IEA --
genes like me logo Genes that share ontologies with ARF1: view
genes like me logo Genes that share phenotypes with ARF1: view

Animal Models for ARF1 Gene

MGI Knock Outs for ARF1:

Animal Model Products

miRNA for ARF1 Gene

miRTarBase miRNAs that target ARF1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARF1 Gene

Localization for ARF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARF1 Gene

Golgi apparatus. Cytoplasm, perinuclear region. Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARF1 Gene COMPARTMENTS Subcellular localization image for ARF1 gene
Compartment Confidence
cytosol 5
endosome 5
extracellular 5
golgi apparatus 5
plasma membrane 5
cytoskeleton 2
endoplasmic reticulum 2
mitochondrion 2
peroxisome 2
vacuole 2
lysosome 1

Gene Ontology (GO) - Cellular Components for ARF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005622 intracellular IEA --
GO:0005778 peroxisomal membrane IEA --
GO:0005829 cytosol IEA,TAS --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with ARF1: view

Pathways & Interactions for ARF1 Gene

genes like me logo Genes that share pathways with ARF1: view

Gene Ontology (GO) - Biological Process for ARF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0006878 cellular copper ion homeostasis IMP 21034850
GO:0006892 post-Golgi vesicle-mediated transport TAS --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with ARF1: view

No data available for SIGNOR curated interactions for ARF1 Gene

Drugs & Compounds for ARF1 Gene

(12) Drugs for ARF1 Gene - From: Novoseek, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycerol Experimental Pharma Target 191
Guanosine triphosphate Experimental Pharma Target 0
1,3-Propandiol Experimental Pharma Target 0
1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE Experimental Pharma Target 0
Guanosine diphosphate Experimental Pharma Target 0

(20) Additional Compounds for ARF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ARF1: view

Transcripts for ARF1 Gene

Unigene Clusters for ARF1 Gene

ADP-ribosylation factor 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARF1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: -
SP7: - - - - - - - - - - -
SP8:
SP9: - - - - - -
SP10: - -
SP11: - - -

Relevant External Links for ARF1 Gene

GeneLoc Exon Structure for
ARF1
ECgene alternative splicing isoforms for
ARF1

Expression for ARF1 Gene

mRNA expression in normal human tissues for ARF1 Gene

Protein differential expression in normal tissues from HIPED for ARF1 Gene

This gene is overexpressed in Blymphocyte (11.7), Tlymphocyte (10.9), Nasal epithelium (6.4), and Cervix (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARF1 Gene



SOURCE GeneReport for Unigene cluster for ARF1 Gene Hs.286221

genes like me logo Genes that share expression patterns with ARF1: view

Protein tissue co-expression partners for ARF1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARF1 Gene

Orthologs for ARF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARF1 36
  • 100 (a)
OneToOne
LOC457177 35
  • 99.63 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia ARF1 36
  • 100 (a)
OneToOne
ARF1 35
  • 90.79 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia LOC607365 35
  • 93 (n)
  • 100 (a)
ARF1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arf1 36
  • 100 (a)
OneToOne
Arf1 16
Arf1 35
  • 91.9 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia ARF1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Arf1 35
  • 91.34 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves ARF1 36
  • 100 (a)
OneToOne
ARF1 35
  • 83.43 (n)
  • 98.9 (a)
lizard
(Anolis carolinensis)
Reptilia ARF1 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arf5 35
  • 81.03 (n)
  • 98.9 (a)
MGC76046 35
zebrafish
(Danio rerio)
Actinopterygii arf1 35
  • 81.67 (n)
  • 98.33 (a)
arf2 36
  • 97 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012014 35
  • 79.89 (n)
  • 96.65 (a)
fruit fly
(Drosophila melanogaster)
Insecta Arf102F 37
  • 82 (a)
Arf79F 37
  • 96 (a)
Arf79F 36
  • 95 (a)
OneToMany
Arf79F 35
  • 77.84 (n)
  • 96.65 (a)
worm
(Caenorhabditis elegans)
Secernentea arf-1.2 36
  • 93 (a)
OneToMany
arf-1.2 35
  • 74.63 (n)
  • 93.89 (a)
arf-1 37
  • 93 (a)
arf-3 37
  • 85 (a)
arl-1 37
  • 58 (a)
arl-5 37
  • 48 (a)
arl-6 37
  • 61 (a)
arl-query 37
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARF1 36
  • 77 (a)
ManyToMany
ARF2 36
  • 77 (a)
ManyToMany
ARF2 38
corn
(Zea mays)
Liliopsida Zm.6331 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15067 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11304 36
  • 82 (a)
ManyToMany
Species with no ortholog for ARF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARF1 Gene

ENSEMBL:
Gene Tree for ARF1 (if available)
TreeFam:
Gene Tree for ARF1 (if available)

Paralogs for ARF1 Gene

Pseudogenes.org Pseudogenes for ARF1 Gene

genes like me logo Genes that share paralogs with ARF1: view

Variants for ARF1 Gene

Sequence variations from dbSNP and Humsavar for ARF1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs822732 -- 228,084,042(-) CACCA(A/G)CCTTG intron-variant
rs822733 -- 228,082,567(-) CACCC(C/T)GCCCC upstream-variant-2KB
rs822734 -- 228,081,388(-) TGGAA(A/C/T)CTTCT upstream-variant-2KB
rs822741 -- 228,099,527(-) CAGCA(A/G)CAGGC downstream-variant-500B
rs1063427 -- 228,098,759(+) GCAGG(C/G)CCCCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ARF1 Gene

Variant ID Type Subtype PubMed ID
esv32853 CNV Gain 17666407
nsv826908 CNV Gain 20364138
nsv516409 CNV Loss 19592680
nsv523935 CNV Loss 19592680
nsv832803 CNV Loss 17160897
nsv873252 CNV Loss 21882294
dgv537n71 CNV Loss 21882294
nsv873255 CNV Loss 21882294

Variation tolerance for ARF1 Gene

Residual Variation Intolerance Score: 38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARF1 Gene

HapMap Linkage Disequilibrium report
ARF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARF1 Gene

Disorders for ARF1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ARF1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cholera
  • cholera - vibrio cholerae
rheumatic myocarditis
  • active rheumatic fever with myocarditis
- elite association - COSMIC cancer census association via MalaCards
Search ARF1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ARF1

Genetic Association Database (GAD)
ARF1
Human Genome Epidemiology (HuGE) Navigator
ARF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARF1
genes like me logo Genes that share disorders with ARF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARF1 Gene

Publications for ARF1 Gene

  1. Characterization of the human gene encoding ADP-ribosylation factor 1, a guanine nucleotide-binding activator of cholera toxin. (PMID: 1577740) Lee C.M. … Vaughan M. (J. Biol. Chem. 1992) 2 3 4 23 67
  2. Role of the second cysteine-rich domain and Pro275 in protein kinase D2 interaction with ADP-ribosylation factor 1, trans-Golgi network recruitment, and protein transport. (PMID: 20089835) Pusapati G.V. … Seufferlein T. (Mol. Biol. Cell 2010) 3 23
  3. Role of the GTPase Rab1b in ebolavirus particle formation. (PMID: 20164217) Yamayoshi S. … Kawaoka Y. (J. Virol. 2010) 3 23
  4. Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN. (PMID: 20228810) Anitei M. … Hoflack B. (Nat. Cell Biol. 2010) 3 23
  5. Arf family GTP loading is activated by, and generates, positive membrane curvature. (PMID: 18597672) Lundmark R. … McMahon H.T. (Biochem. J. 2008) 3 23

Products for ARF1 Gene

Sources for ARF1 Gene

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