Aliases for AREL1 Gene
External Ids for AREL1 Gene
Previous Symbols for AREL1 Gene
GeneCards Summary for AREL1 Gene
AREL1 (Apoptosis Resistant E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is NEDD4.
UniProtKB/Swiss-Prot for AREL1 Gene
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation.