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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AREGB Gene

protein-coding   GIFtS: 44
GCID: GC04P075480          (predicted)

Amphiregulin B

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Amphiregulin B1 2
AR3
CRDGF3
SDGF3
Colorectum Cell-Derived Growth Factor3

External Ids:    HGNC: 345091   Entrez Gene: 7277382   Ensembl: ENSG000002055957   UniProtKB: P155143   

Export aliases for AREGB gene to outside databases

Previous GC identifer: GC04P075700


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for AREGB Gene: 
AREGB (amphiregulin B) is a protein-coding gene. Diseases associated with AREGB include breast adenocarcinoma, and androgen insensitivity syndrome, and among its related super-pathways are ErbB signaling pathway and Development EGFR signaling pathway. GO annotations related to this gene include growth factor activity and cytokine activity. An important paralog of this gene is AREG.

UniProtKB/Swiss-Prot: AREG_HUMAN, P15514
Function: Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of
target cells including astrocytes, Schwann cells and fibroblasts

summary for AREGB Gene:
Androgen receptors (ARs) (also known as dihydrotestosterone receptors) are nuclear hormone receptors of the
NR3C class, which also includes mineralocorticoid, progesterone and glucocorticoid receptors. They are
expressed in bone marrow, mammary gland, prostate, testicular and muscle tissues where they exist as dimers
coupled to Hsp90 and HMGB proteins, which are shed upon ligand binding. Activated androgen receptors bind to
nuclear response elements of the genome, with an inverted palindromic 15 nucleotide sequence, to regulate
gene transcription. Androgen receptors also effect gene expression through interaction with transcription
factors including AP-1, NF-kappaB and STAT. Target genes of androgen receptors include insulin-like growth
factor 1 (IGF-1) and genes involved in the development of primary and secondary male sexual characteristics,
maintenance of sexual function and possibly have a causative role in aggressive behavior. Furthermore,
androgen receptors have recently been shown to have actions that are independent of DNA interactions.
Congential mutations in androgen receptors are associated with androgen insensitivity syndromes, virility
and spinal and bulbar muscular atrophy. Perturbations in androgen receptor expression is also a common
feature of prostate cancer. The human gene encoding the androgen receptor has been localized to Xq11-12.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AREGB gene promoter:
         MAZR   FOXC1   POU2F1   AML1a   POU2F1a   FOXD1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): AREGB promoter sequence
   Search SABiosciences Chromatin IP Primers for AREGB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AREGB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

AREGB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AREGB gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P075480:  view genomic region     (about GC identifiers)

Start:
75,480,629 bp from pter      End:
75,490,486 bp from pter
Size:
9,858 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AREG_HUMAN, P15514 (See protein sequence)
Recommended Name: Amphiregulin precursor  
Size: 252 amino acids; 27895 Da
Subunit: The immature precursor interacts with CNIH
Subcellular location: Membrane; Single-pass membrane protein
Miscellaneous: AR is a protein containing cysteines in disulfide linkage(s) that are essential for its biological
activity. AR may contain oligosaccharides and/or lipid moieties that are not obligatory for the biological
activity
1 PDB 3D structure from and Proteopedia for AREGB:
2RNL (3D)    

Explore the universe of human proteins at neXtProt for AREGB: NX_P15514

Explore proteomics data for AREGB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P15514

  • AREGB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AREGB Protein Expression

    ENSEMBL proteins: 
     ENSP00000370227  

    Human Recombinant Protein Products for AREGB: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for AREGB
    GenScript Custom Purified and Recombinant Proteins Services for AREGB
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AREGB 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA12743035
    GO:0009986cell surface IDA12743035
    GO:0016021integral to membrane IEA--

    AREGB for ontologies           About GeneDecksing



    AREGB Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of AREGB
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for AREGB
    GenScript Custom Superior Antibodies Services for AREGB
    Abcam antibodies for AREGB
    Cloud-Clone Corp. Antibodies for AREGB 
    Search ThermoFisher Antibodies for AREGB
    Search LSBio for Antibodies for AREGB 

    Assay Products for AREGB: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AREGB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for AREGB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for AREGB 
    Cloud-Clone Corp. CLIAs for AREGB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR015497 EGF_rcpt_ligand
     IPR000742 EG-like_dom
     IPR013032 EGF-like_CS

    Graphical View of Domain Structure for InterPro Entry P15514

    ProtoNet protein and cluster: P15514

    1 Blocks protein domain: IPB006210 Type I EGF

    UniProtKB/Swiss-Prot: AREG_HUMAN, P15514
    Similarity: Belongs to the amphiregulin family
    Similarity: Contains 1 EGF-like domain


    AREGB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AREG_HUMAN, P15514
    Function: Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of
    target cells including astrocytes, Schwann cells and fibroblasts
    Induction: By phorbol 12-myristate 13-acetate (PMA)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity IEA--
    GO:0005515protein binding IPI19740107
    GO:0008083growth factor activity IEA--
         
    AREGB for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for AREGB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AREGB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AREGB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AREGB 

    miRNA
    Products:
        
    miRTarBase miRNAs that target AREGB:
    hsa-mir-488 (MIRT003789)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AREGB
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate AREGB
    SwitchGear 3'UTR luciferase reporter plasmidAREGB 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    Browse OriGene RNAi
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AREGB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AREGB
    Sirion Biotech Customized adenovirus for overexpression of AREGB

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    Browse OriGene untagged/tagged cDNA clones in CMV expression vector
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AREGB (XM_001125684)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AREGB
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat AREGB
    Sirion Biotech Customized lentivirus for stable overexpression of AREGB 
                         Customized lentivirus expression plasmids for stable overexpression of AREGB 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AREGB
    Search LifeMap BioReagents cell lines for AREGB
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AREGB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AREGB About                                                                                                See pathways by source

    SuperPathContained pathways About
    1ErbB signaling pathway
    ErbB signaling pathway0.52
    ErbB signaling pathway0.52
    2Development EGFR signaling pathway
    Development EGFR signaling pathway0.87
    Development ERBB-family signaling0.56
    3SHC1 events in ERBB2 signaling
    ErbB receptor signaling network0.34
    4Hippo signaling pathway
    Hippo signaling pathway
    5FSH signaling pathway
    FSH signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for AREGB
        Development ERBB-family signaling
    Development EGFR signaling pathway

    3 BioSystems Pathways for AREGB
        ErbB signaling pathway
    FSH signaling pathway
    ErbB receptor signaling network


    2         Kegg Pathways  (Kegg details for AREGB):
        ErbB signaling pathway
    Hippo signaling pathway


    AREGB for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AREGB

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/8 Interacting proteins for AREGB (P155142, 3 ENSP000003702274) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    S100A4P264472, 3, ENSP000003462944MINT-7256618 MINT-7256636 MINT-7256485 MINT-7256567 I2D: score=1 STRING: ENSP00000346294
    S100A2P290342, 3, ENSP000003576974MINT-7256654 I2D: score=1 STRING: ENSP00000357697
    S100A5P337632, 3, ENSP000003521484MINT-7256693 I2D: score=1 STRING: ENSP00000352148
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2856981 I2D: score=3 STRING: ENSP00000357292
    EGFRP005333I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007173epidermal growth factor receptor signaling pathway IDA12743035
    GO:0007186G-protein coupled receptor signaling pathway IDA12743035
    GO:0007267cell-cell signaling TAS2466334
    GO:0008283cell proliferation TAS2466334
    GO:0045740positive regulation of DNA replication IMP12743035

    AREGB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for AREGB available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TestosteroneEndogenous androgen receptor agonist[58-22-0]
    FlutamideNon-steroidal androgen receptor antagonist[13311-84-7]
    NilutamideAndrogen receptor antagonist. Orally active[63612-50-0]
    BicalutamideNon-steroidal androgen receptor antagonist[90357-06-5]
    Cl-4AS-1Steroidal androgen receptor agonist[188589-66-4]

    Search CenterWatch for drugs/clinical trials and news about AREGB / AREG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380846(uc021xpc.1) ENST00000511772
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AREGB
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate AREGB
    SwitchGear 3'UTR luciferase reporter plasmidAREGB 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    Browse OriGene RNAi
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AREGB
    Clone
    Products:
         
    Browse OriGene untagged/tagged cDNA clones in CMV expression vector
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AREGB (XM_001125684)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AREGB
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat AREGB
    Sirion Biotech Customized lentivirus for stable overexpression of AREGB 
                         Customized lentivirus expression plasmids for stable overexpression of AREGB 
    Primer
    Products:
        
    Browse OriGene qPCR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AREGB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AREGB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AREGB

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AREGB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    AREGB Expression
    About this image


    See AREGB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AREGB
        SABiosciences Custom PCR Arrays for AREGB
    Primer
    Products:
    Browse OriGene qPCR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AREGB
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AREGB
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AREGB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AREGB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for AREGB gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Areg1 amphiregulin 78.1(n)
    72.24(a)
      11839  NM_009704.3  NP_033834.1 
    chicken
    (Gallus gallus)
    Aves AREGB1 amphiregulin B 58.72(n)
    51.16(a)
      428752  NM_001031537.1  NP_001026708.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    39(a)
    1 → many
    6(60320563-60341068)
    zebrafish
    (Danio rerio)
    Actinopterygii AREGB6
    amphiregulin B
    17(a)
    1 → many
    5(6751965-6761733)


    ENSEMBL Gene Tree for AREGB (if available)
    TreeFam Gene Tree for AREGB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AREGB gene
    AREG1 2  HBEGF2  
    1 SIMAP similar gene for AREGB using alignment to 1 protein entry:     AREG_HUMAN:
    AREG

    AREGB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/34 SNPs in AREGB are shown (see all 34)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs26092001,2
    C,F,O,H--75479060(+) ACAAAA/GTACAC 1 -- us2k115Minor allele frequency- G:0.41NS EA NA 2146
    rs1893230741,2
    --75479219(+) ACTCAC/TGTTAT 1 -- us2k10--------
    rs16912611,2
    C,F--75479231(-) ATAATA/GATAAT 1 -- us2k11Minor allele frequency- G:0.00NA 2
    rs758390081,2
    --75479237(+) ATTATT/CATCAT 1 -- us2k11Minor allele frequency- C:0.00NA 2
    rs753173521,2
    --75479240(+) ATCATT/CATTAT 1 -- us2k11Minor allele frequency- C:0.00NA 2
    rs1867781641,2
    --75479243(+) ATCATC/TATTAT 1 -- us2k10--------
    rs759908591,2
    C--75480180(+) TTGAGT/ATAGAA 1 -- us2k12Minor allele frequency- A:0.25NA 4
    rs2001128711,2
    C--75482042(+) CACCTA/GCTCTG 2 Y C mis11Minor allele frequency- G:0.00EU 543
    rs2012299581,2
    C--75482263(+) AGTAGG/AGGATA 1 -- int11Minor allele frequency- A:0.00EU 138
    rs1144964921,2
    F--75482365(+) GTATGT/GCTATC 1 -- int11Minor allele frequency- G:0.04WA 118

    HapMap Linkage Disequilibrium report for AREGB (75480629 - 75490486 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for AREGB: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing AREGB
    DNA2.0 Custom Variant and Variant Library Synthesis for AREGB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    9 diseases for AREGB:    About MalaCards
    breast adenocarcinoma    androgen insensitivity syndrome    spinal-bulbar muscular atrophy    muscular atrophy
    prostate cancer    prostatitis    adenocarcinoma    colorectal cancer
    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for AREGB:
    Breast cancer     Colorectal cancer

    AREGB for disorders           About GeneDecksing

    Genetic Association Database (GAD): AREGB

    Export disorders for AREGB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AREGB gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with AREGB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and function of human amphiregulin: a member of the epidermal growth factor family. (PubMed id 2466334)1, 2 Shoyab M.... Todaro G.J. (1989)
    2. Genetic variants associated with breast size also infl uence breast cancer risk. (PubMed id 22747683)1 Eriksson N....Tung J.Y. (2012)
    3. Epidermal growth factor receptor ligands as new extra cellular targets for the metastasis-promoting S100A4 protein. (PubMed id 19740107)1 KlingelhAPfer J....Lukanidin E.M. (2009)
    4. Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells. (PubMed id 17607000)2 Perez Castro C.... Derynck R. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells. (PubMed id 12743035)1 Gschwind A....Ullrich A. (2003)
    7. Amphiregulin induces tyrosine phosphorylation of the epidermal growth factor receptor and p185erbB2. Evidence that amphiregulin acts exclusively through the epidermal growth factor receptor at the surface of human epithelial cells. (PubMed id 7679104)2 Johnson G.R....Stromberg K. (1993)
    8. Colorectum cell-derived growth factor (CRDGF) is homologous to amphiregulin, a member of the epidermal growth factor family. (PubMed id 1333777)2 Culouscou J.-M....Shoyab M. (1992)
    9. A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin. (PubMed id 2017164)2 Cook P.W.... Shipley G.D. (1991)
    10. The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity. (PubMed id 2325643)2 Plowman G.D.... Shoyab M. (1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 727738 HGNC: 34509 Ensembl:ENSG00000205595 euGenes: HUgn727738 ECgene: AREGB Kegg: 727738
    H-InvDB: AREGB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AREGB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AREGB Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/areg/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AREGB gene:
    Search GeneIP for patents involving AREGB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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