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Aliases for AREG Gene

Aliases for AREG Gene

  • Amphiregulin 2 3
  • Colorectum Cell-Derived Growth Factor 3 4
  • Schwannoma-Derived Growth Factor 2 3
  • Amphiregulin B 2 3
  • AREGB 3 4
  • CRDGF 3 4
  • SDGF 3 4
  • AR 3 4

External Ids for AREG Gene

Previous HGNC Symbols for AREG Gene

  • SDGF
  • AREGB

Previous GeneCards Identifiers for AREG Gene

  • GC04P075300
  • GC04P075550
  • GC04P075711
  • GC04P075777
  • GC04P075675
  • GC04P071121

Summaries for AREG Gene

Entrez Gene Summary for AREG Gene

  • The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions. [provided by RefSeq, Apr 2014]

GeneCards Summary for AREG Gene

AREG (Amphiregulin) is a Protein Coding gene. Diseases associated with AREG include breast cancer and colorectal cancer. Among its related pathways are Signaling by GPCR and Pathways in cancer. GO annotations related to this gene include cytokine activity and epidermal growth factor receptor binding. An important paralog of this gene is HBEGF.

UniProtKB/Swiss-Prot for AREG Gene

  • Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts

Gene Wiki entry for AREG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AREG Gene

Genomics for AREG Gene

Regulatory Elements for AREG Gene

Genomic Location for AREG Gene

Chromosome:
4
Start:
74,445,098 bp from pter
End:
74,455,009 bp from pter
Size:
9,912 bases
Orientation:
Plus strand

Genomic View for AREG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AREG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AREG Gene

Proteins for AREG Gene

  • Protein details for AREG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15514-AREG_HUMAN
    Recommended name:
    Amphiregulin
    Protein Accession:
    P15514
    Secondary Accessions:
    • Q5U026

    Protein attributes for AREG Gene

    Size:
    252 amino acids
    Molecular mass:
    27895 Da
    Quaternary structure:
    • The immature precursor interacts with CNIH.
    Miscellaneous:
    • AR is a protein containing cysteines in disulfide linkage(s) that are essential for its biological activity. AR may contain oligosaccharides and/or lipid moieties that are not obligatory for the biological activity

    Three dimensional structures from OCA and Proteopedia for AREG Gene

neXtProt entry for AREG Gene

Proteomics data for AREG Gene at MOPED

Post-translational modifications for AREG Gene

  • Glycosylation at Asn 30, Ser 41, Thr 52, Ser 53, Asn 113, Asn 119, and Thr 169
  • Modification sites at PhosphoSitePlus

Other Protein References for AREG Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for AREG Gene

Domains & Families for AREG Gene

Gene Families for AREG Gene

Protein Domains for AREG Gene

Suggested Antigen Peptide Sequences for AREG Gene

Graphical View of Domain Structure for InterPro Entry

P15514

UniProtKB/Swiss-Prot:

AREG_HUMAN :
  • Contains 1 EGF-like domain.
  • Belongs to the amphiregulin family.
Domain:
  • Contains 1 EGF-like domain.
Family:
  • Belongs to the amphiregulin family.
genes like me logo Genes that share domains with AREG: view

Function for AREG Gene

Molecular function for AREG Gene

GENATLAS Biochemistry:
amphiregulin,27.9kDa,bifunctional protein possessing an epithelial cell growth regulator (EGF family) and a tumor-inhibitory activity
UniProtKB/Swiss-Prot Function:
Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts
UniProtKB/Swiss-Prot Induction:
By phorbol 12-myristate 13-acetate (PMA)

Gene Ontology (GO) - Molecular Function for AREG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005154 epidermal growth factor receptor binding IBA --
GO:0005515 protein binding IPI 19740107
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with AREG: view
genes like me logo Genes that share phenotypes with AREG: view

Animal Models for AREG Gene

MGI Knock Outs for AREG:

miRNA for AREG Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AREG

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for AREG Gene

Localization for AREG Gene

Subcellular locations from UniProtKB/Swiss-Prot for AREG Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AREG Gene COMPARTMENTS Subcellular localization image for AREG gene
Compartment Confidence
extracellular 5
nucleus 2

Gene Ontology (GO) - Cellular Components for AREG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005615 extracellular space IDA 12743035
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with AREG: view

Pathways & Interactions for AREG Gene

genes like me logo Genes that share pathways with AREG: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for AREG Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for AREG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0007173 epidermal growth factor receptor signaling pathway IDA 12743035
GO:0007186 G-protein coupled receptor signaling pathway IDA 12743035
GO:0007267 cell-cell signaling TAS 2466334
GO:0008283 cell proliferation TAS 2466334
genes like me logo Genes that share ontologies with AREG: view

Drugs & Compounds for AREG Gene

(31) Drugs for AREG Gene - From: NovoSeek and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cetuximab Approved Pharma EGFR Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors 696
Capecitabine Approved, Investigational Pharma RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines 1179
Irinotecan Approved, Investigational Pharma Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1013
Panitumumab Approved, Investigational Pharma EGFR inhibitor, EGFR Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors 0
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437

(24) Additional Compounds for AREG Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
12-O-Tetradecanoylphorbol 13-acetate
8-Chloro-cAMP
Actinomycin D
AG 1478
chlorate
  • Chlorate
  • Chlorate ion
  • Chloric acid
  • Chlorine oxide
14866-68-3
genes like me logo Genes that share compounds with AREG: view

Transcripts for AREG Gene

mRNA/cDNA for AREG Gene

Unigene Clusters for AREG Gene

Amphiregulin:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AREG

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AREG Gene

No ASD Table

Relevant External Links for AREG Gene

GeneLoc Exon Structure for
AREG
ECgene alternative splicing isoforms for
AREG

Expression for AREG Gene

mRNA expression in normal human tissues for AREG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AREG Gene

This gene is overexpressed in Whole Blood (x7.0).

Protein differential expression in normal tissues from HIPED for AREG Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AREG Gene



SOURCE GeneReport for Unigene cluster for AREG Gene Hs.270833

genes like me logo Genes that share expression patterns with AREG: view

Protein tissue co-expression partners for AREG Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for AREG Gene

Orthologs for AREG Gene

This gene was present in the common ancestor of chordates.

Orthologs for AREG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC538751 35
  • 85.77 (n)
  • 79.67 (a)
-- 36
  • 78 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC475176 35
  • 86.75 (n)
  • 83.33 (a)
-- 36
  • 83 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Areg 35
  • 78.1 (n)
  • 72.38 (a)
Areg 16
Areg 36
  • 71 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia AREG 35
  • 99.07 (n)
  • 98.02 (a)
AREG 36
  • 80 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Areg 35
  • 76.19 (n)
  • 71.85 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
OneToMany
chicken
(Gallus gallus)
Aves AREGB 35
  • 59.15 (n)
  • 51.22 (a)
AREG 36
  • 45 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 39 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145251 35
  • 54.9 (n)
  • 42.65 (a)
zebrafish
(Danio rerio)
Actinopterygii AREG 36
  • 22 (a)
OneToMany
Species with no ortholog for AREG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AREG Gene

ENSEMBL:
Gene Tree for AREG (if available)
TreeFam:
Gene Tree for AREG (if available)

Paralogs for AREG Gene

Paralogs for AREG Gene

(2) SIMAP similar genes for AREG Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with AREG: view

Variants for AREG Gene

Sequence variations from dbSNP and Humsavar for AREG Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_018918 -
VAR_018919 -

Structural Variations from Database of Genomic Variants (DGV) for AREG Gene

Variant ID Type Subtype PubMed ID
nsv525980 CNV Gain 19592680
esv2664200 CNV Deletion 23128226
dgv94n16 CNV Insertion 17901297

Variation tolerance for AREG Gene

Gene Damage Index Score: 2.15; 38.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AREG Gene

HapMap Linkage Disequilibrium report
AREG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AREG Gene

Disorders for AREG Gene

MalaCards: The human disease database

(4) MalaCards diseases for AREG Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
colorectal cancer
  • colorectal cancer, somatic
lung cancer
  • lung cancer, protection against
prostate cancer
  • prostate cancer, hereditary, 5
- elite association
Search AREG in MalaCards View complete list of genes associated with diseases

Relevant External Links for AREG

Genetic Association Database (GAD)
AREG
Human Genome Epidemiology (HuGE) Navigator
AREG
Tumor Gene Database (TGDB):
AREG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AREG
genes like me logo Genes that share disorders with AREG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AREG Gene

Publications for AREG Gene

  1. Amphiregulin promotes resistance to gefitinib in nonsmall cell lung cancer cells by regulating Ku70 acetylation. (PMID: 19826407) Busser B. … Hurbin A. (Mol. Ther. 2010) 23 67
  2. Amphiregulin attenuates bleomycin-induced pneumopathy in mice. (PMID: 19915156) Fukumoto J. … Nakanishi Y. (Am. J. Physiol. Lung Cell Mol. Physiol. 2010) 23 67
  3. BRCA1 represses amphiregulin gene expression. (PMID: 20103632) Lamber E.P. … Parvin J.D. (Cancer Res. 2010) 23 67
  4. Insulin-like growth factor I gene transfer to cirrhotic liver induces fibrolysis and reduces fibrogenesis leading to cirrhosis reversion in rats. (PMID: 20198635) Sobrevals L. … Fortes P. (Hepatology 2010) 23 67
  5. The nuclear receptor cofactor receptor-interacting protein 140 is a positive regulator of amphiregulin expression and cumulus cell-oocyte complex expansion in the mouse ovary. (PMID: 20308529) Nautiyal J. … Parker M.G. (Endocrinology 2010) 23 67

Products for AREG Gene

Sources for AREG Gene

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