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AREG Gene

protein-coding GIFtS: 63

GC04P075550

amphiregulin
(Previous name: schwannoma-derived growth factor )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SDGF)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AR ^², ³
CRDGF ^², ³
MGC13647 ^²
OTTHUMP00000160473 ^²
SDGF ^², ³
amphiregulin ^²

Descriptions
Colorectum cell-derived growth factor ^², ³
schwannoma-derived growth factor ^¹, ²

External Ids
HGNC: 651¹
Entrez Gene: 374²
UniProtKB: P15514³
Ensembl: ENSG00000109321⁷

Search outside databases for aliases for AREG gene

Previous GC identifers: GC04P075300 GC04P075711 GC04P075777 GC04P075675

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AREG:

The protein encoded by this gene is a member of the epidermal growth factor family. It is an

autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is

related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This

protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells

and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is

associated with a psoriasis-like skin phenotype. [provided by RefSeq]

UniProtKB/Swiss-Prot: AREG_HUMAN, P15514

Function: Bifunctional growth-modulating glycoprotein. Inhibits growth of several human carcinoma

cells in culture and stimulates proliferation of human fibroblasts and certain other tumor cells

Gene Wiki entry for AREG (Amphiregulin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AREG gene

Entrez Gene cytogenetic band: 4q13-q21 Ensembl cytogenetic band: 4q13.3 HGNC cytogenetic band: 4q13-q21

AREG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P075550: (about GC identifiers)

Start:	75,529,715 bp from pter
End:	75,539,590 bp from pter
Size:	9,876 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000004.10 NT_006216.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: AREG_HUMAN, P15514 (See protein sequence)

Recommended Name: Amphiregulin precursor

Size: 252 amino acids; 27895 Da

Subunit: The immature precursor interacts with CNIH

Subcellular location: Membrane; Single-pass membrane protein

Miscellaneous: AR is a protein containing cysteines in disulfide linkage(s) that are essential for

its biological activity. AR may contain oligosaccharides and/or lipid moieties that are not

obligatory for the biological activity

PDB structures from and Proteopedia :

2RNL (3D)

REFSEQ proteins: NP_001648.1

ENSEMBL proteins:

ENSP00000264487 ENSP00000379097

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for AREG
	R&D Systems Recombinant & Natural Proteins for AREG (Amphiregulin)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Amphiregulin)
	Human Recombinant Proteins from Abnova (AREG)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	TAS	3413110
GO:0009986	cell surface	IDA	12743035
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for AREG:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of AREG
	Sigma-Aldrich Antibodies for AREG
	R&D Systems Antibodies for AREG (Amphiregulin)
	Antibodies from Abcam (Amphiregulin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (AREG)
	Novus Biologicals Antibodies for AREG

Assays for AREG:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for AREG (Amphiregulin) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P15514

ProtoNet protein and cluster: P15514

1 Blocks protein family: IPB006210 Type I EGF

UniProtKB/Swiss-Prot: AREG_HUMAN, P15514

Similarity: Belongs to the amphiregulin family

Similarity: Contains 1 EGF-like domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AREG)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AREG)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001657

Applied Biosystems Silencer® siRNAs for AREG

Sigma-Aldrich siRNA and siRNA Panels for AREG

Sigma-Aldrich shRNA for AREG

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for AREG
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001657
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001657
untagged cDNA clone in CMV expression vector: NM_001657

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001657

UniProtKB/Swiss-Prot: AREG_HUMAN, P15514

Function: Bifunctional growth-modulating glycoprotein. Inhibits growth of several human carcinoma

cells in culture and stimulates proliferation of human fibroblasts and certain other tumor cells

Induction: By phorbol 12-myristate 13-acetate (PMA)

Genatlas biochemistry entry for AREG:

amphiregulin,27.9kDa,bifunctional protein possessing an epithelial cell growth regulator (EGF

family) and a tumor-inhibitory activity

9 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Areg):

	digestive/alimentary	endocrine/exocrine gland	growth/size	immune system
reproductive system	skin/coat/nails	touch/vibrissae	vision/eye

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--
GO:0008083	growth factor activity	TAS	2466334

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for AREG (Your Favorite Gene powered by Ingenuity)

Neuregulin Signaling

GeneDecks AREG for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for AREG

2 Interacting proteins for AREG (P15514² ENSP00000264487³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBQLN4	Q9NRR5²	MINT-2856981
EGFR	ENSP00000275493³	STRING (score=.742)

About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007173	epidermal growth factor receptor signaling pathway	IDA	12743035
GO:0007186	G-protein coupled receptor protein signaling pathway	IDA	12743035
GO:0007267	cell-cell signaling	TAS	2466334
GO:0008283	cell proliferation	TAS	2466334
GO:0045740	positive regulation of DNA replication	IMP	12743035

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AREG
10/23 Novoseek chemical compound relationships for AREG gene (see all 23 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	58.71	49	7679104 (3), 8360173 (2), 9110152 (1), 10579352 (1) (see all 32)
sodium chlorate	51.33	2	9542658 (1), 8138579 (1)
chlorate	40.55	2	7929459 (1), 8138579 (1)
phorbol-12-myristate	40.36	1	17595323 (1)
wortmannin	39.97	1	17274952 (1)
heparan sulfate	31.06	15	2017164 (2), 14660620 (1), 1582998 (1), 16982797 (1) (see all 5)
thymidine	25.69	2	8077234 (1), 16202921 (1)
bryostatin 1	25.58	2	7649107 (1), 8952699 (1)
pd 98,059	24.92	4	9564849 (1), 14701705 (1), 16543407 (1)
forskolin	23.99	7	17520403 (2), 15967414 (1), 15284208 (1), 17595323 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AREG)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AREG)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001657

Sigma-Aldrich siRNA and siRNA Panels for AREG

Sigma-Aldrich shRNA for AREG

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001657

REFSEQ mRNAs for AREG gene:

NM_001657.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001657

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001657
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001657
                                 untagged cDNA clone in CMV expression vector: NM_001657

Additional cDNA sequence:

BC009799.1 BC146953.1 BC146967.1 BT019866.1 CR606995.1 CR608053.1 CR617114.1 M30704.1

10 DOTS entries:

DT.209869 DT.121246074 DT.100826743 DT.100826741 DT.121235551 DT.92414460 DT.121235545 DT.121235549

DT.95267368 DT.97829472

24/90 AceView cDNA sequences (see all 90 ):

M30704 CR608053 CB160040 BM839778 CA455033 CR606995 BC009799 BM846005

CB134173 AI340146 BF175199 BX282107 CB242548 BM762744 BM839991 CB127573

T29526 AW028834 AL546917 BE122791 NM_001657 CB131869 BM764135 CR617114

highest scoring ESTs for AREG:

M30704 AA641709 AI269804 AI340146 AI346365 AL547132 BC009799 BE122791 BX373668 BX398871

Unigene Cluster for AREG:

Amphiregulin

Hs.270833 [show with all ESTs]

Unigene Representative Sequence: BC009799

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000264487 ENST00000395748

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

AREG expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AREG

¹ / ² / ³

4 probe-sets matching AREG gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34898_at²^{, 3}	U95-A	2	1.00	0.50	1.00	1.00	M30704	1.00	0.80	0.91	1
205239_at²^{, 3}	U133-A	2	1.00	0.50	--	--	NM_001657	0.60	1.00	0.82	1
205239_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--
1557285_at*²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTATAGCATA

SOURCE GeneReport for Unigene cluster: Hs.270833
Expression variation in blood from EXPOLDB for AREG

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AREG gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AREGB¹	--	amphiregulin B	85.22(n) 81.17(a)	475176 XM_532410.2 XP_532410.2
chimpanzee (Pan troglodytes)	AREGB¹	--	amphiregulin B	99.07(n) 98.02(a)	461251 XM_517224.2 XP_517224.2
cow (Bos taurus)	AREGB¹	--	amphiregulin B	85.77(n) 80.08(a)	538751 XM_582419.3 XP_582419.2
rat (Rattus norvegicus)	Areg¹	--	amphiregulin	77.32(n) 73.44(a)	29183 NM_017123.1 NP_058819.1
mouse (Mus musculus)	Areg^{1, 5}	5 (51.00 cM)⁵	amphiregulin^{1, 5}	78.1(n)¹ 72.24(a)¹	11839¹ NM_009704.3¹ NP_033834.1¹ AK018590⁵ BC009138⁵ (see all 9)

About this table Species with no ortholog for AREG

ENSEMBL Gene Tree for AREG

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for AREG gene

AREGB¹ ² HBEGF²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

7 NCBI SNPs in AREG are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs28364976^1,2	F	75530634(+)	`AAAATATGAA CAC/-ATCTT`	1	--	int¹		1		NS	120
--	rs56293680^1,2	--	75528333(+)	`ATTATC/TATTAT`	1	--	ng5¹		0	--	--	--	--
--	rs56378975^1,2	--	75534979(-)	`TCACCA/GAAATA`	1	F/F	syn¹		0	--	--	--	--
--	rs28364977^1,2	--	75530784(+)	`GGAATG/CTGAAG`	1	--	int¹		1		NS	160
--	rs56179913^1,2	--	75534899(+)	`GGAGAA/GTAAGC`	1	--	int¹		0	--	--	--	--
--	rs35643945^1,2	--	75530753(+)	`TGGCA-/TTTCTA`	1	--	int¹		0	--	--	--	--
--	rs55838452^1,2	--	75532838(-)	`TATGCA/GATTTT`	1	--	int¹		0	--	--	--	--

About this table
The following additional 22 SNP(s) have been found in Applied Biosystems data source:

(Click for Applied Biosystems TaqMan ® Genotyping Assay)

rs1353295	rs2132065	rs4350980	rs1874202	rs1691274	rs1797569	rs6830356
rs1691276	rs1691275	rs2367711	rs10518122	rs6820341	rs1797591	rs8180348
rs1353296	rs1691273	rs1691277	rs28583397	rs28755927	rs11725706	rs11723281
rs1622064

HapMap Linkage Disequilibrium images for AREG (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 104640

10/71 Novoseek disease relationships for AREG gene (see all 71 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ovarian cystadenoma	50.95	2	7814196 (1)
breast cancer	50.38	59	8101763 (3), 17670913 (3), 18437539 (3), 17942395 (3) (see all 32)
tumors	47.37	118	8407551 (4), 8621257 (3), 1596904 (3), 10597254 (3) (see all 57)
colon carcinoma	45.86	14	1639855 (2), 9260917 (2), 1591731 (2), 9466051 (2) (see all 7)
nsclc	44.87	40	16230376 (4), 15033751 (3), 18980991 (2), 15767261 (2) (see all 10)
breast carcinoma	40.43	17	9935161 (2), 7749138 (2), 9285119 (2), 7579500 (2) (see all 9)
carcinoma	35.48	45	8523820 (4), 1306686 (3), 11523048 (3), 1953719 (3) (see all 19)
colon cancer	35.42	14	14742435 (3), 7558427 (1), 8523820 (1), 10024674 (1) (see all 9)
cancer	33.02	22	18023415 (2), 8033121 (1), 9563874 (1), 15474502 (1) (see all 15)
hyperplasia	29.41	14	16470170 (3), 8959346 (2), 15793282 (2), 9256328 (1) (see all 8)

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Tumor Gene Database: AREG

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/410 PubMed articles for AREG gene (see all 410 ):

Colorectum cell-derived growth factor (CRDGF) is homologous to amphiregulin, a member of the epidermal growth factor family. (PubMed id 1333777)^{1, 3, 4} Culouscou J.-M....Shoyab M. (1992)
A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin. (PubMed id 2017164)^{1, 3, 4} Cook P.W.... Shipley G.D. (1991)
The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity. (PubMed id 2325643)^{1, 3, 4} Plowman G.D.... Shoyab M. (1990)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Structure and function of human amphiregulin: a member of the epidermal growth factor family. (PubMed id 2466334)^{3, 4} Shoyab M.... Todaro G.J. (1989)
Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7. (PubMed id 3413110)^{3, 4} Shoyab M.... Todaro G.J. (1988)
Autocrine and juxtacrine effects of amphiregulin on the proliferative, invasive, and migratory properties of normal and neoplastic human mammary epithelial cells. (PubMed id 17035230)^{1, 3} Willmarth N.E. and Ethier S.P. (2006)
Human airway trypsin-like protease induces amphiregulin release through a mechanism involving protease-activated receptor-2-mediated ERK activation and TNF alpha-converting enzyme activity in airway epithelial cells. (PubMed id 16336275)^{1, 3} Chokki M....Kamimura T. (2005)
The epidermal growth factor-like growth factor amphiregulin is strongly induced by the adenosine 3',5'-monophosphate pathway in various cell types. (PubMed id 15284208)^{1, 3} Johansson C.C....Tasken K. (2004)
Amphiregulin is much more abundantly expressed than transforming growth factor-alpha and epidermal growth factor in human follicular fluid obtained from patients undergoing in vitro fertilization-embryo transfer. (PubMed id 18325497)^{1, 3} Inoue Y....Kawarabayashi T. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 374	HGNC: 651	AceView: AREG	Ensembl:ENSG00000109321	euGenes: HUgn374
ECgene: AREG	H-InvDB: AREG

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for AREG	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/areg/

Licensable Technologies for AREG
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for AREG:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AREG-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for AREG		Antibodies for AREG
	Explore super-pooled esiRNAs		Proteins for AREG
	Lentivirus-delivered shRNAs for AREG		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (AREG)
	Antibodies (AREG)
	Chimera RNAi (AREG)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Amphiregulin)
	Antibodies (Amphiregulin)

Search OriGene for AREG

Search Tocris compounds for AREG

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for AREG

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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AREG Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for AREG

Summaries
for AREG

Genomic Location
for AREG

Proteins
for AREG

Protein Domains/
Families
for AREG

Gene Function
for AREG

Pathways & Interactions
for AREG

Drugs & Compounds
for AREG

Transcripts
for AREG

Expression
for AREG

Orthologs
for AREG

Paralogs
for AREG

SNPs/Variants
for AREG

Disorders & Mutations
for AREG

Medical News
for AREG

Publications
for AREG

Search for AREG

Genome Databases showing AREG

Other Databases showing AREG

Specialized Databases showing AREG

Licensable Technologies
for AREG

Services
for AREG

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AREG Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor AREG

Summariesfor AREG

Genomic Locationfor AREG

Proteinsfor AREG

Protein Domains/Familiesfor AREG

Gene Functionfor AREG

Pathways & Interactionsfor AREG

Drugs & Compoundsfor AREG

Transcriptsfor AREG

Expression for AREG

Orthologsfor AREG

Paralogsfor AREG

SNPs/Variantsfor AREG

Disorders & Mutationsfor AREG

Medical Newsfor AREG

Publicationsfor AREG

Search for AREG

Genome Databases showing AREG

Other Databases showing AREG

Specialized Databases showing AREG

Licensable Technologiesfor AREG

Servicesfor AREG

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AREG

Summaries
for AREG

Genomic Location
for AREG

Proteins
for AREG

Protein Domains/
Families
for AREG

Gene Function
for AREG

Pathways & Interactions
for AREG

Drugs & Compounds
for AREG

Transcripts
for AREG

Expression
for AREG

Orthologs
for AREG

Paralogs
for AREG

SNPs/Variants
for AREG

Disorders & Mutations
for AREG

Medical News
for AREG

Publications
for AREG

Licensable Technologies
for AREG

Services
for AREG