Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AREG Gene

protein-coding   GIFtS: 68
GCID: GC04P075300

Amphiregulin

(Previous name: schwannoma-derived growth factor)
(Previous symbol: SDGF)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
amphiregulin1 2
SDGF1 2 3
Schwannoma-Derived Growth Factor1 2
Colorectum Cell-Derived Growth Factor2 3
AR2 3
CRDGF2 3

External Ids:    HGNC: 6511   Entrez Gene: 3742   Ensembl: ENSG000001093217   OMIM: 1046405   UniProtKB: P155143   

Export aliases for AREG gene to outside databases

Previous GC identifers: GC04P075550 GC04P075711 GC04P075777 GC04P075675 GC04P071121


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AREG Gene:
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth
factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth
factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha
receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma
cell lines. This encoded protein is associated with a psoriasis-like skin phenotype. (provided by RefSeq, Jul
2008)

GeneCards Summary for AREG Gene: 
AREG (amphiregulin) is a protein-coding gene. Diseases associated with AREG include anemia of prematurity, and ovarian cystadenoma, and among its related super-pathways are ErbB signaling pathway and Rac1 Pathway. An important paralog of this gene is AREGB.

UniProtKB/Swiss-Prot: AREG_HUMAN, P15514
Function: Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of
target cells including astrocytes, Schwann cells and fibroblasts

summary for AREG Gene:
Androgen receptors (ARs) (also known as dihydrotestosterone receptors) are nuclear hormone receptors of the
NR3C class, which also includes mineralocorticoid, progesterone and glucocorticoid receptors. They are
expressed in bone marrow, mammary gland, prostate, testicular and muscle tissues where they exist as dimers
coupled to Hsp90 and HMGB proteins, which are shed upon ligand binding. Activated androgen receptors bind to
nuclear response elements of the genome, with an inverted palindromic 15 nucleotide sequence, to regulate
gene transcription. Androgen receptors also effect gene expression through interaction with transcription
factors including AP-1, NF-kappaB and STAT. Target genes of androgen receptors include insulin-like growth
factor 1 (IGF-1) and genes involved in the development of primary and secondary male sexual characteristics,
maintenance of sexual function and possibly have a causative role in aggressive behavior. Furthermore,
androgen receptors have recently been shown to have actions that are independent of DNA interactions.
Congential mutations in androgen receptors are associated with androgen insensitivity syndromes, virility
and spinal and bulbar muscular atrophy. Perturbations in androgen receptor expression is also a common
feature of prostate cancer. The human gene encoding the androgen receptor has been localized to Xq11-12.

Gene Wiki entry for AREG (Amphiregulin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AREG gene promoter:
         AML1a   AP-1   POU2F1a   ATF-2   STAT3   c-Jun   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAREG promoter sequence
   Search SABiosciences Chromatin IP Primers for AREG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AREG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

AREG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AREG gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P075300:  view genomic region     (about GC identifiers)

Start:
75,310,851 bp from pter      End:
75,320,726 bp from pter
Size:
9,876 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AREG_HUMAN, P15514 (See protein sequence)
Recommended Name: Amphiregulin precursor  
Size: 252 amino acids; 27895 Da
Subunit: The immature precursor interacts with CNIH
Subcellular location: Membrane; Single-pass membrane protein
Miscellaneous: AR is a protein containing cysteines in disulfide linkage(s) that are essential for its biological
activity. AR may contain oligosaccharides and/or lipid moieties that are not obligatory for the biological
activity
1 PDB 3D structure from and Proteopedia for AREG:
2RNL (3D)    

Explore the universe of human proteins at neXtProt for AREG: NX_P15514

Explore proteomics data for AREG at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P15514

  • AREG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AREG Protein Expression
    REFSEQ proteins: NP_001648.1  
    ENSEMBL proteins: 
     ENSP00000379097   ENSP00000421414   ENSP00000264487  

    Human Recombinant Protein Products for AREG: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for AREG (Amphiregulin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for AREG
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for AREG
    GenScript Custom Purified and Recombinant Proteins Services for AREG
    Novus Biologicals AREG Proteins
    Novus Biologicals AREG Lysates
    Sino Biological Recombinant Protein for AREG
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for AREG
    Cloud-Clone Corp. Proteins for AREG 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space ----
    GO:0009986cell surface ----
    GO:0016021integral to membrane ----

    AREG for ontologies           About GeneDecksing



    AREG Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of AREG
    R&D Systems Antibodies for AREG (Amphiregulin)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for AREG
    GenScript Custom Superior Antibodies Services for AREG
    Novus Biologicals AREG Antibodies
    Abcam antibodies for AREG
    Cloud-Clone Corp. Antibodies for AREG 
    ThermoFisher Antibody for AREG
    LSBio Antibodies in human, mouse, rat for AREG 

    Assay Products for AREG: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for AREG
    R&D Systems ELISAs for AREG (Amphiregulin)         (see all)
    GenScript Custom Assay Services for AREG
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for AREG 
    Cloud-Clone Corp. CLIAs for AREG


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR015497 EGF_rcpt_ligand
     IPR000742 EG-like_dom
     IPR013032 EGF-like_CS

    Graphical View of Domain Structure for InterPro Entry P15514

    ProtoNet protein and cluster: P15514

    1 Blocks protein domain: IPB006210 Type I EGF

    UniProtKB/Swiss-Prot: AREG_HUMAN, P15514
    Similarity: Belongs to the amphiregulin family
    Similarity: Contains 1 EGF-like domain


    AREG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AREG_HUMAN, P15514
    Function: Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of
    target cells including astrocytes, Schwann cells and fibroblasts
    Induction: By phorbol 12-myristate 13-acetate (PMA)

         Genatlas biochemistry entry for AREG:
    amphiregulin,27.9kDa,bifunctional protein possessing an epithelial cell growth regulator (EGF family) and a
    tumor-inhibitory activity

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity ----
    GO:0005515protein binding ----
    GO:0008083growth factor activity ----
         
    AREG for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for AREG:
     Increased cell death in HCC-19 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Areg):
     cardiovascular system  digestive/alimentary  endocrine/exocrine gland  growth/size  immune system 
     integument  reproductive system  vision/eye 

    AREG for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Aregtm1Dle for AREG

       inGenious Targeting Laboratory - Custom generated mouse model solutions for AREG 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AREG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AREG 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AREG 

    miRNA
    Products:
        
    miRTarBase miRNAs that target AREG:
    hsa-mir-488 (MIRT003789)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AREG
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate AREG:
    hsa-miR-548t hsa-miR-34c-5p hsa-miR-34a hsa-miR-449b hsa-miR-561 hsa-miR-944 hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmidAREG 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AREG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AREG

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for AREG
    Sirion Biotech Customized adenovirus for overexpression of AREG

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for AREG (see all 6)
    OriGene ORF clones in mouse, rat for AREG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AREG (NM_001657)
    Sino Biological Human cDNA Clone for AREG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AREG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AREG
    Sirion Biotech Customized lentivirus for stable overexpression of AREG 
                         Customized lentivirus expression plasmids for stable overexpression of AREG 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for AREG
    Search LifeMap BioReagents cell lines for AREG
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AREG


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AREG About   (see all 19)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    ErbB signaling pathway0.52
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    4Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for AREG
        Development ERBB-family signaling
    Development EGFR signaling pathway

    5/55 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for AREG (see all 55)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 GeneGo (Thomson Reuters) Pathways for AREG
        Development ERBB-family signaling
    Development EGFR signaling pathway

    3 BioSystems Pathways for AREG
        ErbB signaling pathway
    FSH signaling pathway
    ErbB receptor signaling network

    1 Sino Biological Pathway for AREG 
        EGFR Signaling Pathway

    1 PharmGKB Pathway for AREG
        EGFR Inhibitor Pathway, Pharmacodynamics

    2         Kegg Pathways  (Kegg details for AREG):
        ErbB signaling pathway
    Hippo signaling pathway


    AREG for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for AREG

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/8 Interacting proteins for AREG (P155142, 3 ENSP000002644874) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    S100A4P264472, 3MINT-7256618 MINT-7256636 MINT-7256485 MINT-7256567 I2D: score=1 
    S100A2P290342, 3MINT-7256654 I2D: score=1 
    S100A5P337632, 3MINT-7256693 I2D: score=1 
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2856981 I2D: score=3 STRING: ENSP00000357292
    CCND3P302813, ENSP000003620824I2D: score=1 STRING: ENSP00000362082
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007173epidermal growth factor receptor signaling pathway ----
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007267cell-cell signaling ----
    GO:0008283cell proliferation ----
    GO:0045740positive regulation of DNA replication ----

    AREG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AREG for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for AREG available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TestosteroneEndogenous androgen receptor agonist[58-22-0]
    FlutamideNon-steroidal androgen receptor antagonist[13311-84-7]
    NilutamideAndrogen receptor antagonist. Orally active[63612-50-0]
    BicalutamideNon-steroidal androgen receptor antagonist[90357-06-5]
    Cl-4AS-1Steroidal androgen receptor agonist[188589-66-4]

    10/51 Novoseek inferred chemical compound relationships for AREG gene (see all 51)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ag 1478 75.1 8 16543407 (2), 16737974 (1), 14701705 (1), 15705969 (1)
    gefitinib 72.8 40 19826406 (8), 18980991 (4), 19826407 (4), 16230376 (4) (see all 15)
    pd153035 72.7 1 17533397 (1)
    8-chloro-camp 63.3 1 9815703 (1)
    cetuximab 61.1 11 17664471 (3), 18980991 (2), 19738126 (2), 19663767 (1) (see all 5)
    tyrosine 59.3 49 7679104 (3), 8360173 (2), 9110152 (1), 10579352 (1) (see all 32)
    heparin 51.8 74 12236483 (5), 8138579 (5), 1522124 (4), 11218236 (3) (see all 33)
    sodium chlorate 49.8 2 9542658 (1), 8138579 (1)
    erlotinib 43 2 18980991 (2)
    phorbol-12-myristate 39.3 1 17595323 (1)

    Search CenterWatch for drugs/clinical trials and news about AREG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AREG gene: 
    NM_001657.2  

    Unigene Cluster for AREG:

    Amphiregulin
    Hs.270833  [show with all ESTs]
    Unigene Representative Sequence: BC009799
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395748 ENST00000502307 ENST00000511560 ENST00000264487
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AREG
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate AREG:
    hsa-miR-548t hsa-miR-34c-5p hsa-miR-34a hsa-miR-449b hsa-miR-561 hsa-miR-944 hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmidAREG 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for AREG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AREG
    Clone
    Products:
         
    OriGene clones in human, mouse for AREG (see all 6)
    OriGene ORF clones in mouse, rat for AREG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AREG (NM_001657)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AREG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AREG
    Sirion Biotech Customized lentivirus for stable overexpression of AREG 
                         Customized lentivirus expression plasmids for stable overexpression of AREG 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for AREG
    OriGene qSTAR qPCR primer pairs in human, mouse for AREG
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AREG
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AREG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AREG

    Additional mRNA sequence: 

    BC009799.1 BC146953.1 BC146967.1 BT019866.1 M30704.1 

    11 DOTS entries:

    DT.209869  DT.121246074  DT.100826743  DT.100826741  DT.97829472  DT.121235551  DT.92414460  DT.70103291 
    DT.121235545  DT.121235549  DT.95267368 

    24/90 AceView cDNA sequences (see all 90):

    CB242548 CR608053 CR606995 BE122791 AI340146 T29526 NM_001657 BF175199 
    CB160040 BC009799 BM839778 CB127573 AL546917 CB131869 BM762744 BX282107 
    AW028834 BM839991 M30704 CA455033 BM764135 CB134173 BM846005 CR617114 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AREG expression in normal human tissues (normalized intensities)      AREG embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTATAGCATA
    AREG Expression
    About this image


    AREG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Epidermis (Integumentary System)    fully expand to see all 3 entries
             Intermediate Keratinocytes Embryonic Epidermis
     
     Mesoderm (Gastrulation Derivatives)
             Intermediate Mesoderm Cells Intermediate Mesoderm
     
     Lung (Respiratory System)
             Basal Cells Respiratory Bronchioles
     
     Hair
             Basal Keratinocytes Embryonic Epidermis
     
     Ovary (Reproductive System)
             Mural Granulosa Cells Antral Follicle

    See AREG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AREG

    SOURCE GeneReport for Unigene cluster: Hs.270833
        SABiosciences Expression via Pathway-Focused PCR Arrays including AREG: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Common Cytokines in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Allergy & Asthma in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for AREG
    OriGene qSTAR qPCR primer pairs in human, mouse for AREG
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AREG
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AREG
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AREG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AREG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for AREG gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Areg1 , 5 amphiregulin1, 5 78.1(n)1
    72.24(a)1
      5 (44.78 cM)5
    118391  NM_009704.31  NP_033834.11 
     911396155 
    chicken
    (Gallus gallus)
    Aves AREGB1 amphiregulin B 58.72(n)
    51.16(a)
      428752  NM_001031537.1  NP_001026708.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    39(a)
    1 → many
    6(60320563-60341068)
    zebrafish
    (Danio rerio)
    Actinopterygii AREGB6
    amphiregulin B
    17(a)
    1 → many
    5(6751965-6761733)


    ENSEMBL Gene Tree for AREG (if available)
    TreeFam Gene Tree for AREG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AREG gene
    AREGB1 2  HBEGF2  
    2 SIMAP similar genes for AREG using alignment to 3 protein entries:     AREG_HUMAN (see all proteins):
    AREGB    EGF

    AREG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/39 SNPs in AREG are shown (see all 39)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0189194
    ----see VAR_0189192 Y C mis40--------
    VAR_0189184
    ----see VAR_0189182 D V mis40--------
    rs562936801,2
    C--75309469(+) ATTATC/TATTAT 1 -- us2k10--------
    rs283649761,2
    F--75311770(+) AAAATATGAA   
       CAC
    /-
    ATCTT
    1 -- int11Minor allele frequency- -:0.35NS 120
    rs283649771,2
    C--75311920(+) GGAATG/CTGAAG 1 -- int13Minor allele frequency- C:0.01NS NA 164
    rs1443073861,2
    C--75312232(+) CTTCCC/TTTATT 1 -- int10--------
    rs1472269851,2
    C,F--75312431(+) CGACTA/GTGACT 2 Y C mis11Minor allele frequency- G:0.00NA 3078
    rs1845828921,2
    --75312593(+) TTTCTA/GGTGGC 1 -- int10--------
    rs2021539981,2
    C--75312686(+) TGATCA/GTAAAT 1 -- int10--------
    rs2000752681,2
    C--75312780(+) AAGCCA/GAAAAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for AREG (75310851 - 75320726 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for AREG:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2664200CNV Deletion23128226
    dgv94n16CNV Insertion17901297
    nsv525980CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing AREG
    DNA2.0 Custom Variant and Variant Library Synthesis for AREG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 104640    OMIM disorders: --

    20/71 diseases for AREG (see all 71):    About MalaCards
    anemia of prematurity    ovarian cystadenoma    psoriasis    cystadenoma
    lung squamous cell carcinoma    androgen insensitivity syndrome    spinal-bulbar muscular atrophy    keratoacanthoma
    fibrous dysplasia    muscular atrophy    gastritis    colon adenocarcinoma
    mucoepidermoid carcinoma    breast adenocarcinoma    atrophic gastritis    bladder carcinoma
    malignant mesothelioma    neurofibroma    cystadenocarcinoma    bronchitis

    2 diseases from the University of Copenhagen DISEASES database for AREG:
    Breast cancer     Colorectal cancer

    AREG for disorders           About GeneDecksing

    10/72 Novoseek inferred disease relationships for AREG gene (see all 72)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 50 60 8101763 (3), 17670913 (3), 18437539 (3), 17942395 (3) (see all 33)
    ovarian cystadenoma 49.6 2 7814196 (1)
    nsclc 49.3 52 16230376 (4), 19826406 (4), 15033751 (3), 18980991 (2) (see all 14)
    tumors 48.6 121 8407551 (4), 8621257 (3), 10597254 (3), 1596904 (3) (see all 59)
    colon carcinoma 44.4 14 1639855 (2), 9260917 (2), 1591731 (2), 9466051 (2) (see all 7)
    breast carcinoma 40.4 17 9935161 (2), 7749138 (2), 9285119 (2), 7579500 (2) (see all 9)
    cancer 34.4 22 18023415 (2), 8033121 (1), 9563874 (1), 15474502 (1) (see all 15)
    carcinoma 33.8 45 8523820 (4), 1306686 (3), 11523048 (3), 1953719 (3) (see all 19)
    colon cancer 33.2 14 14742435 (3), 7558427 (1), 8523820 (1), 10024674 (1) (see all 9)
    colorectal cancer 30 14 18413824 (6), 19738126 (2), 9563874 (1), 16685431 (1) (see all 6)

    Genetic Association Database (GAD): AREG
    Human Genome Epidemiology (HuGE) Navigator: AREG (4 documents)
    Tumor Gene Database (TGDB): AREG

    Export disorders for AREG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AREG gene, integrated from 9 sources (see all 493):
    (articles sorted by number of sources associating them with AREG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Colorectum cell-derived growth factor (CRDGF) is homologous to amphiregulin, a member of the epidermal growth factor family. (PubMed id 1333777)1, 2, 9 Culouscou J.-M....Shoyab M. (1992)
    2. A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin. (PubMed id 2017164)1, 2, 9 Cook P.W.... Shipley G.D. (1991)
    3. The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity. (PubMed id 2325643)1, 2, 9 Plowman G.D.... Shoyab M. (1990)
    4. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Structure and function of human amphiregulin: a member of the epidermal growth factor family. (PubMed id 2466334)1, 2 Shoyab M.... Todaro G.J. (1989)
    7. Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7. (PubMed id 3413110)1, 2 Shoyab M.... Todaro G.J. (1988)
    8. Autocrine and juxtacrine effects of amphiregulin on the proliferative, invasive, and migratory properties of normal and neoplastic human mammary epithelial cells. (PubMed id 17035230)1, 9 Willmarth N.E. and Ethier S.P. (2006)
    9. Human airway trypsin-like protease induces amphiregulin release through a mechanism involving protease-activated receptor-2-mediated ERK activation and TNF alpha-converting enzyme activity in airway epithelial cells. (PubMed id 16336275)1, 9 Chokki M....Kamimura T. (2005)
    10. The epidermal growth factor-like growth factor amphiregulin is strongly induced by the adenosine 3',5'-monophosphate pathway in various cell types. (PubMed id 15284208)1, 9 Johansson C.C....Tasken K. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 374 HGNC: 651 AceView: AREG Ensembl:ENSG00000109321 euGenes: HUgn374
    ECgene: AREG Kegg: 374 H-InvDB: AREG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AREG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for AREG Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/areg/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AREG gene:
    Search GeneIP for patents involving AREG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of AREG
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for AREG (Amphiregulin)   Browse Cell Culture Products  
     ELISAs for AREG (Amphiregulin)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for AREG (Amphiregulin)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for AREG (Amphiregulin)  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for AREG  
     OriGene qPCR primer pairs and template standards for AREG   OriGene Protein Over-expression Lysate for AREG  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for AREG  
     OriGene qSTAR qPCR primer pairs in human, mouse for AREG   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for AREG   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for AREG   OriGene Custom Protein Services for AREG  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AREG
     QIAGEN SeqTarget long-range PCR primers for resequencing AREG
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AREG
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AREG
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AREG
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AREG
     GenScript Custom Purified and Recombinant Proteins Services for AREG GenScript cDNA clones with any tag delivered in your preferred vector for AREG
     GenScript Custom Assay Services for AREG GenScript Custom Superior Antibodies Services for AREG
     GenScript Custom overexpressing Cell Line Services for AREG CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in AREG promoter
     Search Chromatin IP Primers for AREG
     RT2 qPCR Primer Assay in human, mouse, rat AREG
     GNC Network for AREG
     SABiosciences PCR Arrays including human, mouse, rat AREG
     Tocris compounds for AREG
     Proteins and Antibodies for AREG
     Browse Sino Biological Cell Lysates
     cDNA Clones for AREG
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     AREG antibodies
     AREG proteins
     AREG lysates
     Antibodies for AREG
     See all of Abcam's Antibodies, Kits and Proteins for AREG
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for AREG




     Proteins for AREG
     Antibodies for AREG
     ELISAs for AREG
     CLIAs for AREG
     Search LifeMap BioReagents cell lines for AREG
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AREG
     SwitchGear 3'UTR luciferase reporter plasmids for AREG
     SwitchGear Promoter luciferase reporter plasmids for AREG
     ThermoFisher Antibody for AREG
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AREG
     inGenious Targeting Laboratory - Custom generated mouse model solutions for AREG
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AREG
    Customized:
     lentivirus for stable overexpression of AREG
     lentivirus expression plasmids for stable overexpression of AREG
     adenovirus for overexpression of AREG
     LSBio Antibodies in human, mouse, rat for AREG
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      AREG gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4