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Aliases for ARCN1 Gene

Aliases for ARCN1 Gene

  • Archain 1 2 3 5
  • Coatomer Protein Complex, Subunit Delta 2 3
  • Delta-Coat Protein 3 4
  • Delta-COP 3 4
  • COPD 3 4
  • Archain Vesicle Transport Protein 1 3
  • Coatomer Protein Delta-COP 3
  • Coatomer Delta Subunit 3
  • Archain 4

External Ids for ARCN1 Gene

Previous HGNC Symbols for ARCN1 Gene

  • COPD

Previous GeneCards Identifiers for ARCN1 Gene

  • GC11P120799
  • GC11P119954
  • GC11P118477
  • GC11P117980
  • GC11P117948
  • GC11P118444
  • GC11P114380

Summaries for ARCN1 Gene

Entrez Gene Summary for ARCN1 Gene

  • This gene maps in a region, which include the mixed lineage leukemia and Friend leukemia virus integration 1 genes, where multiple disease-associated chromosome translocations occur. It is an intracellular protein. Archain sequences are well conserved among eukaryotes and this protein may play a fundamental role in eukaryotic cell biology. It has similarities to heat shock proteins and clathrin-associated proteins, and may be involved in vesicle structure or trafficking. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARCN1 Gene

ARCN1 (Archain 1) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF). GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for ARCN1 Gene

  • The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARCN1 Gene

Genomics for ARCN1 Gene

Regulatory Elements for ARCN1 Gene

Enhancers for ARCN1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARCN1 on UCSC Golden Path with GeneCards custom track

Promoters for ARCN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARCN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARCN1 Gene

Chromosome:
11
Start:
118,572,387 bp from pter
End:
118,603,033 bp from pter
Size:
30,647 bases
Orientation:
Plus strand

Genomic View for ARCN1 Gene

Genes around ARCN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARCN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARCN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARCN1 Gene

Proteins for ARCN1 Gene

  • Protein details for ARCN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48444-COPD_HUMAN
    Recommended name:
    Coatomer subunit delta
    Protein Accession:
    P48444
    Secondary Accessions:
    • B4E1X2
    • E9PEU4
    • Q52M80

    Protein attributes for ARCN1 Gene

    Size:
    511 amino acids
    Molecular mass:
    57210 Da
    Quaternary structure:
    • Oligomeric complex that consists of at least the alpha, beta, beta, gamma, delta, epsilon and zeta subunits.
    SequenceCaution:
    • Sequence=CAA57072.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ARCN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARCN1 Gene

Proteomics data for ARCN1 Gene at MOPED

Post-translational modifications for ARCN1 Gene

  • Ubiquitination at Lys 38, Lys 142, Lys 233, Lys 256, Lys 263, Lys 336, Lys 363, and Lys 485
  • Modification sites at PhosphoSitePlus

Other Protein References for ARCN1 Gene

No data available for DME Specific Peptides for ARCN1 Gene

Domains & Families for ARCN1 Gene

Protein Domains for ARCN1 Gene

Suggested Antigen Peptide Sequences for ARCN1 Gene

Graphical View of Domain Structure for InterPro Entry

P48444

UniProtKB/Swiss-Prot:

COPD_HUMAN :
  • Contains 1 MHD (mu homology) domain.
  • Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
Domain:
  • Contains 1 MHD (mu homology) domain.
Family:
  • Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
genes like me logo Genes that share domains with ARCN1: view

No data available for Gene Families for ARCN1 Gene

Function for ARCN1 Gene

Molecular function for ARCN1 Gene

GENATLAS Biochemistry:
archain,homologous to DNA sequences from Drosophila and mice
UniProtKB/Swiss-Prot Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
genes like me logo Genes that share phenotypes with ARCN1: view

Animal Models for ARCN1 Gene

MGI Knock Outs for ARCN1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARCN1 Gene

Localization for ARCN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARCN1 Gene

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARCN1 Gene COMPARTMENTS Subcellular localization image for ARCN1 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
endoplasmic reticulum 3
mitochondrion 2
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ARCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0030133 transport vesicle TAS --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with ARCN1: view

Pathways & Interactions for ARCN1 Gene

genes like me logo Genes that share pathways with ARCN1: view

Gene Ontology (GO) - Biological Process for ARCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008344 adult locomotory behavior IEA --
GO:0015031 protein transport IEA --
GO:0021691 cerebellar Purkinje cell layer maturation IEA --
GO:0061024 membrane organization TAS --
genes like me logo Genes that share ontologies with ARCN1: view

No data available for SIGNOR curated interactions for ARCN1 Gene

Drugs & Compounds for ARCN1 Gene

(1) Drugs for ARCN1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARCN1: view

Transcripts for ARCN1 Gene

Unigene Clusters for ARCN1 Gene

Archain 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARCN1 Gene

No ASD Table

Relevant External Links for ARCN1 Gene

GeneLoc Exon Structure for
ARCN1
ECgene alternative splicing isoforms for
ARCN1

Expression for ARCN1 Gene

mRNA expression in normal human tissues for ARCN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARCN1 Gene

This gene is overexpressed in Salivary gland (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARCN1 Gene



SOURCE GeneReport for Unigene cluster for ARCN1 Gene Hs.33642

mRNA Expression by UniProt/SwissProt for ARCN1 Gene

P48444-COPD_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with ARCN1: view

Protein tissue co-expression partners for ARCN1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for ARCN1 Gene

Orthologs for ARCN1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARCN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARCN1 35
  • 93.35 (n)
  • 98.24 (a)
ARCN1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARCN1 35
  • 94.13 (n)
  • 98.83 (a)
ARCN1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arcn1 35
  • 92.5 (n)
  • 99.02 (a)
Arcn1 16
Arcn1 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARCN1 35
  • 99.93 (n)
  • 100 (a)
ARCN1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arcn1 35
  • 92.43 (n)
  • 98.83 (a)
oppossum
(Monodelphis domestica)
Mammalia ARCN1 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARCN1 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARCN1 35
  • 81.44 (n)
  • 94.9 (a)
ARCN1 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARCN1 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arcn1 35
  • 76.13 (n)
  • 88.06 (a)
Str.824 35
African clawed frog
(Xenopus laevis)
Amphibia arcn1-prov 35
zebrafish
(Danio rerio)
Actinopterygii arcn1a 35
  • 73.54 (n)
  • 82.91 (a)
arcn1a 36
  • 83 (a)
OneToMany
arcn1b 36
  • 81 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2657 35
fruit fly
(Drosophila melanogaster)
Insecta dgrCOP 37
  • 56 (a)
deltaCOP 35
  • 58.3 (n)
  • 60.59 (a)
deltaCOP 36
  • 58 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010719 35
  • 59.96 (n)
  • 63.12 (a)
worm
(Caenorhabditis elegans)
Secernentea C13B9.3 37
  • 47 (a)
C13B9.3 35
  • 54.48 (n)
  • 52.81 (a)
copd-1 36
  • 50 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RET2 36
  • 31 (a)
OneToOne
RET2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G05010 35
  • 54.43 (n)
  • 43.41 (a)
soybean
(Glycine max)
eudicotyledons Gma.2422 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.561 35
rice
(Oryza sativa)
Liliopsida Os05g0311000 35
  • 53.99 (n)
  • 45.88 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.23804 35
corn
(Zea mays)
Liliopsida Zm.17239 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7899 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9714 36
  • 65 (a)
OneToOne
Species with no ortholog for ARCN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ARCN1 Gene

ENSEMBL:
Gene Tree for ARCN1 (if available)
TreeFam:
Gene Tree for ARCN1 (if available)

Paralogs for ARCN1 Gene

(1) SIMAP similar genes for ARCN1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ARCN1: view

No data available for Paralogs for ARCN1 Gene

Variants for ARCN1 Gene

Sequence variations from dbSNP and Humsavar for ARCN1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs682327 - 118,583,919(-) CTGCC(A/C)AATCC reference, missense
rs1063124 - 118,590,449(+) GACAA(C/G)TATGG reference, missense
rs534237 -- 118,575,251(+) gggat(A/T)atagg intron-variant
rs535774 -- 118,597,322(+) TCCTA(C/T)AAAGA intron-variant
rs584325 -- 118,598,123(+) CAGAC(A/C)AAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARCN1 Gene

Variant ID Type Subtype PubMed ID
dgv1319n71 CNV Loss 21882294
nsv832283 CNV Loss 17160897

Variation tolerance for ARCN1 Gene

Residual Variation Intolerance Score: 22.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.15% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ARCN1 Gene

Disorders for ARCN1 Gene

Relevant External Links for ARCN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARCN1

No disorders were found for ARCN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARCN1 Gene

Publications for ARCN1 Gene

  1. The human archain gene, ARCN1, has highly conserved homologs in rice and Drosophila. (PMID: 7782067) Radice P. … Tunnacliffe A. (Genomics 1995) 2 3 4 23 67
  2. The coatomer protein delta-COP, encoded by the archain gene, is conserved across diverse eukaryotes. (PMID: 8854871) Tunnacliffe A. … Radice P. (Mamm. Genome 1996) 2 3 23
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for ARCN1 Gene

Sources for ARCN1 Gene

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