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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARCN1 Gene

protein-coding   GIFtS: 64
GCID: GC11P118444

Archain 1

(Previous names: coatomer protein complex, subunit delta)
(Previous symbol: COPD)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Archain 11 2     Coatomer Protein Delta-COP2
COPD1 2 3     Coatomer Subunit Delta2
Coatomer Protein Complex, Subunit Delta1 2     delta-COP2
Delta-Coat Protein2 3     Archain3
Archain Vesicle Transport Protein 12     Delta-COP3
Coatomer Delta Subunit2     

External Ids:    HGNC: 6491   Entrez Gene: 3722   Ensembl: ENSG000000951397   OMIM: 6008205   UniProtKB: P484443   

Export aliases for ARCN1 gene to outside databases

Previous GC identifers: GC11P120799 GC11P119954 GC11P118477 GC11P117980 GC11P117948 GC11P114380


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARCN1 Gene:
This gene maps in a region, which include the mixed lineage leukemia and Friend leukemia virus integration 1
genes, where multiple disease-associated chromosome translocations occur. It is an intracellular protein. Archain
sequences are well conserved among eukaryotes and this protein may play a fundamental role in eukaryotic cell
biology. It has similarities to heat shock proteins and clathrin-associated proteins, and may be involved in
vesicle structure or trafficking. (provided by RefSeq, Jul 2008)

GeneCards Summary for ARCN1 Gene: 
ARCN1 (archain 1) is a protein-coding gene. Diseases associated with ARCN1 include leukemia, and thyroiditis, and among its related super-pathways are Clathrin-dependent protein traffic and Golgi to ER Retrograde Transport.

UniProtKB/Swiss-Prot: COPD_HUMAN, P48444
Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with
Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the
Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is
essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only
be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins;
the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic
recycling of LDL receptors (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARCN1 gene promoter:
         Elk-1   AML1a   AP-4   Evi-1   AREB6   NRF-2   POU2F1   POU2F1a   Msx-1   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARCN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARCN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARCN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

ARCN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARCN1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P118444:  view genomic region     (about GC identifiers)

Start:
118,443,102 bp from pter      End:
118,473,748 bp from pter
Size:
30,647 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: COPD_HUMAN, P48444 (See protein sequence)
Recommended Name: Coatomer subunit delta  
Size: 511 amino acids; 57210 Da
Subunit: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta
subunits
Subcellular location: Cytoplasm (By similarity). Golgi apparatus membrane; Peripheral membrane protein;
Cytoplasmic side (By similarity). Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein;
Cytoplasmic side (By similarity). Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the
Golgi, as well as on the vesicles/buds originating from it (By similarity)
Sequence caution: Sequence=CAA57072.1; Type=Erroneous initiation;
Secondary accessions: B4E1X2 E9PEU4 Q52M80
Alternative splicing: 2 isoforms:  P48444-1   P48444-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARCN1: NX_P48444

Explore proteomics data for ARCN1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P48444

  • ARCN1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARCN1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001135753.1  NP_001646.2  

    ENSEMBL proteins: 
     ENSP00000376599   ENSP00000352385   ENSP00000431676   ENSP00000264028  
    Reactome Protein details: P48444
    Human Recombinant Protein Products for ARCN1: 
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    Cloud-Clone Corp. Proteins for ARCN1 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus ----
    GO:0005829cytosol TAS--
    GO:0030126COPI vesicle coat ISS--
    GO:0030131clathrin adaptor complex IEA--

    ARCN1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR008968 Clathrin_mu_C
     IPR022775 AP_mu_sigma_su
     IPR011012 Longin-like_dom
     IPR027059 Coatomer_dsu

    Graphical View of Domain Structure for InterPro Entry P48444

    ProtoNet protein and cluster: P48444

    1 Blocks protein domain: IPB001392 Clathrin adaptor complex

    UniProtKB/Swiss-Prot: COPD_HUMAN, P48444
    Similarity: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily
    Similarity: Contains 1 MHD (mu homology) domain


    ARCN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COPD_HUMAN, P48444
    Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with
    Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the
    Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is
    essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only
    be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins;
    the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic
    recycling of LDL receptors (By similarity)

         Genatlas biochemistry entry for ARCN1:
    archain,homologous to DNA sequences from Drosophila and mice

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    ARCN1 for ontologies           About GeneDecksing


    Phenotypes:
         12 GenomeRNAi human phenotypes for ARCN1:
     Decreased Hepatitis C virus re  Decreased Salmonella enterica   Decreased Salmonella-containin  Decreased Wnt reporter activit 
     Decreased cell number, increas  Decreased homologous recombina  Decreased influenza A virus in  Decreased influenza A/WSN/33 r 
     Decreased viability  G0/1 arrest  Increased Salmonella enterica   Increased gamma-H2AX phosphory 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Arcn1):
     behavior/neurological  cellular  growth/size  hematopoietic system  integument 
     limbs/digits/tail  nervous system  pigmentation 

    ARCN1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ARCN1 
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    miRNA
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    miRTarBase miRNAs that target ARCN1:
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    hsa-miR-548j hsa-miR-3938 hsa-miR-361-5p hsa-miR-517a hsa-miR-374a hsa-miR-578 hsa-miR-877* hsa-miR-1243
    SwitchGear 3'UTR luciferase reporter plasmidARCN1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARCN1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Clathrin-dependent protein traffic
    Clathrin-dependent protein traffic0.66
    wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)0.37
    Transport Clathrin-coated vesicle cycle0.66
    2Golgi to ER Retrograde Transport
    Golgi to ER Retrograde Transport0.31
    COPI Mediated Transport0.31
    Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)0.31
    3COPII (Coat Protein 2) Mediated Vesicle Transport
    Delta508-CFTR traffic / ER-to-Golgi in CF0.36
    Normal wtCFTR traffic / ER-to-Golgi 0.36
    4Membrane Trafficking
    Membrane Trafficking0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ARCN1
        Clathrin-dependent protein traffic


    5 GeneGo (Thomson Reuters) Pathways for ARCN1
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Delta508-CFTR traffic / ER-to-Golgi in CF
    Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)
    Normal wtCFTR traffic / ER-to-Golgi
    Transport Clathrin-coated vesicle cycle

    3        Reactome Pathways for ARCN1
        Membrane Trafficking
    COPI Mediated Transport
    Golgi to ER Retrograde Transport



    ARCN1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARCN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/925 Interacting proteins for ARCN1 (P484442, 3 ENSP000002640284) via UniProtKB, MINT, STRING, and/or I2D (see all 925)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPAP536212, 3, ENSP000003570484MINT-7945693 MINT-8217717 MINT-7947479 I2D: score=7 STRING: ENSP00000357048
    COPB1P536182, 3, ENSP000002499234MINT-7945693 MINT-8217717 MINT-7947479 I2D: score=12 STRING: ENSP00000249923
    COPG1Q9Y6782, 3, ENSP000003250024MINT-7945693 MINT-8217717 MINT-7947479 I2D: score=1 STRING: ENSP00000325002
    COPB2P356062, 3, ENSP000003294194MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000329419
    ACTBP607092, 3MINT-7945693 MINT-7947479 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006886intracellular protein transport IEA--
    GO:0006890retrograde vesicle-mediated transport, Golgi to ER TAS--
    GO:0008344adult locomotory behavior IEA--
    GO:0016192vesicle-mediated transport ----

    ARCN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARCN1 (COPD)

    1 HMDB Compound for ARCN1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about ARCN1 / COPD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARCN1 gene (2 alternative transcripts): 
    NM_001142281.1  NM_001655.4  

    Unigene Cluster for ARCN1:

    Archain 1
    Hs.33642  [show with all ESTs]
    Unigene Representative Sequence: BX640860
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392859 ENST00000359415(uc001ptq.3 uc010ryg.2 uc009zag.3)
    ENST00000534182 ENST00000264028
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    hsa-miR-548j hsa-miR-3938 hsa-miR-361-5p hsa-miR-517a hsa-miR-374a hsa-miR-578 hsa-miR-877* hsa-miR-1243
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    Additional mRNA sequence: 

    AK304019.1 AK312298.1 BC064936.1 BC080638.1 BC093636.1 BC093638.1 BX640860.1 X81197.1 

    18 DOTS entries:

    DT.100797134  DT.100735790  DT.95118968  DT.101981263  DT.100797132  DT.100865355  DT.455908  DT.91811393 
    DT.120717195  DT.100797137  DT.86844962  DT.91759191  DT.100836269  DT.120717246  DT.100027800  DT.100797135 
    DT.120717272  DT.120717209 

    24/755 AceView cDNA sequences (see all 755):

    AI091869 CA389397 CD612399 BQ722854 AA491237 AA490750 AI288707 BM665728 
    BE326512 CA392278 CR592091 BU622476 NM_001655 AA301931 BQ431517 AI950897 
    F04702 CB136714 AI002397 BX095123 BU786850 AI769314 CB853669 BE670529 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARCN1 expression in normal human tissues (normalized intensities)      ARCN1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAGTTAAGC
    ARCN1 Expression
    About this image


    ARCN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)
             HSF-1 (UC01)

    See ARCN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARCN1

    SOURCE GeneReport for Unigene cluster: Hs.33642

    UniProtKB/Swiss-Prot: COPD_HUMAN, P48444
    Tissue specificity: Ubiquitously expressed

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARCN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARCN1 gene from 10/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arcn11 , 5 archain 11, 5 92.5(n)1
    99.02(a)1
      9 (24.84 cM)5
    2138271  NM_145985.41  NP_666097.31 
     447415645 
    chicken
    (Gallus gallus)
    Aves ARCN11 archain 1 81.44(n)
    94.9(a)
      770561  NM_001079499.1  NP_001072967.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARCN16
    archain 1
    85(a)
    1 ↔ 1
    GL343767.1(16056-78765)
    African clawed frog
    (Xenopus laevis)
    Amphibia arcn1-prov2 archain 1 77.93(n)    BC056030.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC050499.12   -- 75.84(n)    BC050499.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta &dgr;COP3
    deltaCOP1
    retrograde (Golgi to ER) transport3
    delta-coatomer protein1
    56(a)3
    58.22(n)1
    61.1(a)1
      452501  NM_001169171.11  NP_001162642.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C13B9.31 , 3 Protein C13B9.31 47(a)3
    54.48(n)1
    52.81(a)1
      III(6694709-6696721)3
    1759401  NM_066062.31  NP_498463.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RET2(YFR051C)4 Delta subunit of the coatomer complex (COPI), which more   --   6(251803-250163) 850612  NP_116709.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G050101 coatomer subunit delta 53.17(n)
    41.47(a)
      830383  NM_001036759.2  NP_001031836.1 
    rice
    (Oryza sativa)
    Liliopsida NM_190465.12   -- 73.94(n)    NM_190465.1 


    ENSEMBL Gene Tree for ARCN1 (if available)
    TreeFam Gene Tree for ARCN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARCN1 gene
    1 SIMAP similar gene for ARCN1 using alignment to 5 protein entries:     COPD_HUMAN (see all proteins):
    DKFZp686M09245

    ARCN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/717 SNPs in ARCN1 are shown (see all 717)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1476828521,2
    --118441228(+) GCACTC/GAATTA 2 -- us2k10--------
    rs1161594781,2
    F--118441262(+) TGGACA/CTACAG 2 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1424365591,2
    C--118441470(+) TTTTCA/GCCATT 2 -- us2k10--------
    rs1866007121,2
    --118441538(+) TTAAAC/GATATA 2 -- us2k10--------
    rs1920206081,2
    --118441554(+) CAAATA/CATAAA 2 -- us2k10--------
    rs5041931,2
    C,H--118441582(-) taaatT/Ggtata 2 -- us2k15Minor allele frequency- G:0.00EA NS NA 270
    rs1837835571,2
    --118441620(+) TAGTTC/TCAGAA 2 -- us2k10--------
    rs1876641911,2
    --118441695(+) AAGCCA/GTCCTC 2 -- us2k10--------
    rs758003971,2
    C,F--118441783(+) TTCCAG/TAAATA 2 -- us2k12Minor allele frequency- T:0.07CSA WA 120
    rs108922431,2
    C,F,A,H--118441846(+) GGAAAT/CCACTA 2 -- us2k1 tfbs320Minor allele frequency- C:0.25NS EA NA CSA WA 2377

    HapMap Linkage Disequilibrium report for ARCN1 (118443102 - 118473748 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ARCN1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832283CNV Loss17160897
    dgv1319n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600820    OMIM disorders: --

    2 diseases for ARCN1:    About MalaCards
    leukemia    thyroiditis


    ARCN1 for disorders           About GeneDecksing


    Export disorders for ARCN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARCN1 gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with ARCN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human archain gene, ARCN1, has highly conserved homologs in rice and Drosophila. (PubMed id 7782067)1, 2, 3, 9 Radice P....Tunnacliffe A. (1995)
    2. The coatomer protein delta-COP, encoded by the archain gene, is conserved across diverse eukaryotes. (PubMed id 8854871)1, 3, 9 Tunnacliffe A....Radice P. (1996)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. Crystallization and preliminary X-ray analysis of the C-terminal domain of d-COP, a medium-sized subunit of the COPI complex involved in membrane trafficking. (PubMed id 22750876)1 Deng K....Sun Z. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. Proteomic analysis of a4b1 integrin adhesion complexes reveals a-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (2012)
    8. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    9. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 372 HGNC: 649 AceView: ARCN1andPHLDB1 Ensembl:ENSG00000095139 euGenes: HUgn372
    ECgene: ARCN1 H-InvDB: ARCN1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARCN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ARCN1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARCN1 gene:
    Search GeneIP for patents involving ARCN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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