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Aliases for ARCN1 Gene

Aliases for ARCN1 Gene

  • Archain 1 2 3
  • Coatomer Protein Complex, Subunit Delta 2 3
  • Delta-Coat Protein 3 4
  • Delta-COP 3 4
  • COPD 3 4
  • Archain Vesicle Transport Protein 1 3
  • Coatomer Protein Delta-COP 3
  • Coatomer Delta Subunit 3
  • Coatomer Subunit Delta 3
  • Archain 4

External Ids for ARCN1 Gene

Previous HGNC Symbols for ARCN1 Gene

  • COPD

Previous GeneCards Identifiers for ARCN1 Gene

  • GC11P120799
  • GC11P119954
  • GC11P118477
  • GC11P117980
  • GC11P117948
  • GC11P118444
  • GC11P114380

Summaries for ARCN1 Gene

Entrez Gene Summary for ARCN1 Gene

  • This gene maps in a region, which include the mixed lineage leukemia and Friend leukemia virus integration 1 genes, where multiple disease-associated chromosome translocations occur. It is an intracellular protein. Archain sequences are well conserved among eukaryotes and this protein may play a fundamental role in eukaryotic cell biology. It has similarities to heat shock proteins and clathrin-associated proteins, and may be involved in vesicle structure or trafficking. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARCN1 Gene

ARCN1 (Archain 1) is a Protein Coding gene. Among its related pathways are COPI Mediated Transport and COPI Mediated Transport.

UniProtKB/Swiss-Prot for ARCN1 Gene

  • The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARCN1 Gene

Genomics for ARCN1 Gene

Regulatory Elements for ARCN1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARCN1 Gene

Start:
118,572,363 bp from pter
End:
118,603,033 bp from pter
Size:
30,671 bases
Orientation:
Plus strand

Genomic View for ARCN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARCN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARCN1 Gene

Proteins for ARCN1 Gene

  • Protein details for ARCN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48444-COPD_HUMAN
    Recommended name:
    Coatomer subunit delta
    Protein Accession:
    P48444
    Secondary Accessions:
    • B4E1X2
    • E9PEU4
    • Q52M80

    Protein attributes for ARCN1 Gene

    Size:
    511 amino acids
    Molecular mass:
    57210 Da
    Quaternary structure:
    • Oligomeric complex that consists of at least the alpha, beta, beta, gamma, delta, epsilon and zeta subunits
    SequenceCaution:
    • Sequence=CAA57072.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ARCN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARCN1 Gene

Proteomics data for ARCN1 Gene at MOPED

Post-translational modifications for ARCN1 Gene

  • Ubiquitination at Lys38, Lys142, Lys233, Lys241, Lys256, Lys263, Lys336, Lys351, Lys363, and Lys485
  • Modification sites at PhosphoSitePlus

Other Protein References for ARCN1 Gene

No data available for DME Specific Peptides for ARCN1 Gene

Domains for ARCN1 Gene

Suggested Antigen Peptide Sequences for ARCN1 Gene

Graphical View of Domain Structure for InterPro Entry

P48444

UniProtKB/Swiss-Prot:

COPD_HUMAN :
  • P48444
Domain:
  • Contains 1 MHD (mu homology) domain.
Family:
  • Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
genes like me logo Genes that share domains with ARCN1: view

No data available for Gene Families for ARCN1 Gene

Function for ARCN1 Gene

Molecular function for ARCN1 Gene

GENATLAS Biochemistry: archain,homologous to DNA sequences from Drosophila and mice
UniProtKB/Swiss-Prot Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).

Gene Ontology (GO) - Molecular Function for ARCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ARCN1: view
genes like me logo Genes that share phenotypes with ARCN1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARCN1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARCN1 Gene

Localization for ARCN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARCN1 Gene

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARCN1 Gene COMPARTMENTS Subcellular localization image for ARCN1 gene
Compartment Confidence
golgi apparatus 5
cytosol 4
mitochondrion 2
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ARCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ARCN1: view

Pathways for ARCN1 Gene

genes like me logo Genes that share pathways with ARCN1: view

Gene Ontology (GO) - Biological Process for ARCN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006886 intracellular protein transport IEA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0008344 adult locomotory behavior IEA --
GO:0016192 vesicle-mediated transport --
genes like me logo Genes that share ontologies with ARCN1: view

Compounds for ARCN1 Gene

(1) HMDB Compounds for ARCN1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with ARCN1: view

Transcripts for ARCN1 Gene

Unigene Clusters for ARCN1 Gene

Archain 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARCN1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARCN1 Gene

No ASD Table

Relevant External Links for ARCN1 Gene

GeneLoc Exon Structure for
ARCN1
ECgene alternative splicing isoforms for
ARCN1

Expression for ARCN1 Gene

mRNA expression in normal human tissues for ARCN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARCN1 Gene

SOURCE GeneReport for Unigene cluster for ARCN1 Gene Hs.33642

mRNA Expression by UniProt/SwissProt for ARCN1 Gene

P48444-COPD_HUMAN
Tissue specificity: Ubiquitously expressed
genes like me logo Genes that share expressions with ARCN1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ARCN1 Gene

Orthologs for ARCN1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARCN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARCN1 35
  • 99.93 (n)
  • 100 (a)
ARCN1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARCN1 35
  • 93.35 (n)
  • 98.24 (a)
ARCN1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARCN1 35
  • 94.13 (n)
  • 98.83 (a)
ARCN1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arcn1 35
  • 92.5 (n)
  • 99.02 (a)
Arcn1 16
Arcn1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARCN1 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARCN1 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arcn1 35
  • 92.43 (n)
  • 98.83 (a)
chicken
(Gallus gallus)
Aves ARCN1 35
  • 81.44 (n)
  • 94.9 (a)
ARCN1 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARCN1 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia arcn1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia arcn1 35
  • 76.13 (n)
  • 88.06 (a)
Str.824 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2657 35
zebrafish
(Danio rerio)
Actinopterygii arcn1a 35
  • 73.54 (n)
  • 82.91 (a)
arcn1a 36
  • 83 (a)
OneToMany
arcn1b 36
  • 81 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010719 35
  • 59.96 (n)
  • 63.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta deltaCOP 35
  • 58.3 (n)
  • 60.59 (a)
deltaCOP 36
  • 58 (a)
OneToOne
dgrCOP 37
  • 56 (a)
worm
(Caenorhabditis elegans)
Secernentea C13B9.3 35
  • 54.48 (n)
  • 52.81 (a)
copd-1 36
  • 50 (a)
OneToOne
C13B9.3 37
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RET2 36
  • 31 (a)
OneToOne
RET2 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.561 35
soybean
(Glycine max)
eudicotyledons Gma.2422 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G05010 35
  • 54.43 (n)
  • 43.41 (a)
corn
(Zea mays)
Liliopsida Zm.17239 35
rice
(Oryza sativa)
Liliopsida Os05g0311000 35
  • 53.99 (n)
  • 45.88 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.23804 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7899 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9714 36
  • 65 (a)
OneToOne
Species with no ortholog for ARCN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ARCN1 Gene

ENSEMBL:
Gene Tree for ARCN1 (if available)
TreeFam:
Gene Tree for ARCN1 (if available)

Paralogs for ARCN1 Gene

Selected SIMAP similar genes for ARCN1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ARCN1: view

No data available for Paralogs for ARCN1 Gene

Variants for ARCN1 Gene

Sequence variations from dbSNP and Humsavar for ARCN1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs15130 -- 118,602,788(+) AAACC(C/T)TTTTT utr-variant-3-prime
rs17742 -- 118,602,670(-) TCCCA(A/G)GCCCT utr-variant-3-prime
rs504193 -- 118,570,867(-) taaat(G/T)gtata upstream-variant-2KB
rs517943 -- 118,581,802(+) GTAAT(A/G)TTTTT intron-variant
rs534237 -- 118,575,251(+) gggat(A/T)atagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARCN1 Gene

Variant ID Type Subtype PubMed ID
dgv1319n71 CNV Loss 21882294
nsv832283 CNV Loss 17160897

Relevant External Links for ARCN1 Gene

HapMap Linkage Disequilibrium report
ARCN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARCN1 Gene

Disorders for ARCN1 Gene

No disorders were found for ARCN1 Gene.

No data available for UniProtKB/Swiss-Prot for ARCN1 Gene

Publications for ARCN1 Gene

  1. The human archain gene, ARCN1, has highly conserved homologs in rice and Drosophila. (PMID: 7782067) Radice P. … Tunnacliffe A. (Genomics 1995) 2 3 4 23
  2. The coatomer protein delta-COP, encoded by the archain gene, is conserved across diverse eukaryotes. (PMID: 8854871) Tunnacliffe A. … Radice P. (Mamm. Genome 1996) 2 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Large-scale analysis of the human ubiquitin-related proteome. (PMID: 16196087) Matsumoto M. … Nakayama K.I. (Proteomics 2005) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ARCN1 Gene

Sources for ARCN1 Gene

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