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ARC Gene

protein-coding   GIFtS: 56
GCID: GC08M143690

Activity-Regulated Cytoskeleton-Associated Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Activity-Regulated Cytoskeleton-Associated Protein1 2
Activity-Regulated Gene 3.1 Protein Homolog2 3
ARC/ARG3.12 3
Arg3.12 3
KIAA02783 5

External Ids:    HGNC: 6481   Entrez Gene: 232372   Ensembl: ENSG000001985767   OMIM: 6124615   UniProtKB: Q7LC443   

Export aliases for ARC gene to outside databases

Previous GC identifers: GC08U990084 GC08M143591 GC08M138948


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ARC Gene:
ARC (activity-regulated cytoskeleton-associated protein) is a protein-coding gene. Diseases associated with ARC include myoclonus, familial cortical, and idiopathic generalized epilepsy.

UniProtKB/Swiss-Prot: ARC_HUMAN, Q7LC44
Function: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates
endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA
receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization.
Required in the stress fiber dynamics and cell migration




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARC gene promoter:
         Sp1   NRSF form 1   STAT5A   NRSF form 2   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARC promoter sequence
   Search Chromatin IP Primers for ARC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

ARC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARC gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M143690:  view genomic region     (about GC identifiers)

Start:
143,692,405 bp from pter      End:
143,696,833 bp from pter
Size:
4,429 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARC_HUMAN, Q7LC44 (See protein sequence)
Recommended Name: Activity-regulated cytoskeleton-associated protein  
Size: 396 amino acids; 45316 Da
Subunit: Interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 and DNM2/DYN2 (By similarity)
Sequence caution: Sequence=BAA19667.1; Type=Erroneous initiation;
Secondary accessions: Q9UJW6 Q9Y469

Explore the universe of human proteins at neXtProt for ARC: NX_Q7LC44

Explore proteomics data for ARC at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056008.1  
    ENSEMBL proteins: 
     ENSP00000349022  

    ARC Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for ARC
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    Novus Biologicals ARC Proteins
    Novus Biologicals ARC Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ARC
    Cloud-Clone Corp. Proteins for ARC

    ARC Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ARC
    Browse R&D Systems for Antibodies
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    OriGene Custom Antibody Services for ARC
    Novus Biologicals ARC Antibodies
    Abcam antibodies for ARC
    Cloud-Clone Corp. Antibodies for ARC
    ThermoFisher Antibodies for ARC
    LSBio Antibodies in human, mouse, rat for ARC

    ARC Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ARC
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARC
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ARC
    Cloud-Clone Corp. CLIAs for ARC


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR023263 Activity-reg_cytoskelet-assoc

    Graphical View of Domain Structure for InterPro Entry Q7LC44

    ProtoNet protein and cluster: Q7LC44

    UniProtKB/Swiss-Prot: ARC_HUMAN, Q7LC44
    Similarity: Belongs to the ARC/ARG3.1 family


    ARC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARC_HUMAN, Q7LC44
    Function: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates
    endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA
    receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization.
    Required in the stress fiber dynamics and cell migration

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    ARC for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Arc):
     behavior/neurological  embryogenesis  growth/size/body  mortality/aging  nervous system 
     no phenotypic analysis 

    ARC for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ARC: Arctm1.1Kuhl Arctm1Amt

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARC
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARC
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARC

    miRNA
    Products:
        
    miRTarBase miRNAs that target ARC:
    hsa-mir-378a-5p (MIRT043974)

    Block miRNA regulation of human, mouse, rat ARC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARC (see all 17):
    hsa-miR-495 hsa-miR-600 hsa-miR-3194-5p hsa-miR-1321 hsa-miR-520d-5p hsa-miR-769-5p hsa-miR-7-2* hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidARC 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ARC
    Predesigned siRNA for gene silencing in human, mouse, rat ARC

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ARC

    Clone
    Products:
         
    OriGene clones in human, mouse for ARC (see all 7)
    OriGene ORF clones in mouse, rat for ARC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ARC (NM_001142281)
    Sino Biological Human cDNA Clone for ARC
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARC

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ARC
    Browse ESI BIO Cell Lines and PureStem Progenitors for ARC 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARC_HUMAN, Q7LC44: Cytoplasm, cytoskeleton (By similarity). Endosome (By similarity). Cytoplasmic vesicle,
    secretory vesicle, acrosome (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic
    density (By similarity). Cell projection, dendrite (By similarity). Cell projection, dendritic spine (By
    similarity). Cell junction, synapse (By similarity). Note=Associated with the cell cortex of neuronal soma and
    dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail (By similarity).
    Enriched on the plasma membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    cytosol2
    endosome2
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005737cytoplasm IDA--
    GO:0005768endosome IEA--
    GO:0005886plasma membrane IDA--
    GO:0014069postsynaptic density IEA--

    ARC for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARC About    
    See pathways by source

    SuperPathContained pathways About
    1Amphetamine addiction
    Amphetamine addiction0.44
    2PEDF Induced Signaling
    Glucocorticoid Receptor Signaling0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ARC
        Glucocorticoid Receptor Signaling



    1 Kegg Pathway  (Kegg details for ARC):
        Amphetamine addiction


    ARC for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including ARC: 
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ARC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARC (Q7LC442, 3 ENSP000003490224) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRT15P190122, 3, ENSP000002540434MINT-67831 I2D: score=5 STRING: ENSP00000254043
    GRIN1Q055863, ENSP000003606164I2D: score=1 STRING: ENSP00000360616
    CYFIP1Q7L5763, ENSP000003245494I2D: score=1 STRING: ENSP00000324549
    DLG4P783523I2D: score=1 
    GRIN2BQ132243I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--
    GO:0007010cytoskeleton organization IMP--
    GO:0007492endoderm development IEA--
    GO:0007612learning IEA--
    GO:0009952anterior/posterior pattern specification IEA--

    ARC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARC

    3 Novoseek inferred chemical compound relationships for ARC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nmda 27.5 3 12559831 (1), 18614031 (1)
    tyrosine 1.45 3 11880195 (2), 14969744 (1)
    dopamine 0 1 16908598 (1)



    ARC for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARC gene: 
    NM_015193.4  

    Unigene Cluster for ARC:

    Activity-regulated cytoskeleton-associated protein
    Hs.40888  [show with all ESTs]
    Unigene Representative Sequence: BC075802
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356613(uc003ywn.1) ENST00000581404
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ARC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARC (see all 17):
    hsa-miR-495 hsa-miR-600 hsa-miR-3194-5p hsa-miR-1321 hsa-miR-520d-5p hsa-miR-769-5p hsa-miR-7-2* hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidARC 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ARC
    Predesigned siRNA for gene silencing in human, mouse, rat ARC
    Clone
    Products:
         
    OriGene clones in human, mouse for ARC (see all 7)
    OriGene ORF clones in mouse, rat for ARC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ARC (NM_001142281)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARC
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ARC
    OriGene qSTAR qPCR primer pairs in human, mouse for ARC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARC
      QuantiTect SYBR Green Assays in human, mouse, rat ARC
      QuantiFast Probe-based Assays in human, mouse, rat ARC

    Additional mRNA sequence: 

    AF193421.1 BC012321.1 BC075802.1 D87468.1 

    2 DOTS entries:

    DT.105171  DT.95264726 

    Selected AceView cDNA sequences (see all 40):

    BC012321 AI972927 BG054976 CB154449 NM_015193 BI752734 BG056710 BF338615 
    CB156410 BE855583 BE795019 BG058542 BI116320 D87468 BF525603 AF193421 
    AW015459 BC075802 BE797482 BG339449 AI498494 AI399718 BF312181 BG056647 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGCTGTGGC
    ARC Expression
    About this image


    ARC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             S-shaped Body
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
    ARC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.40888
        Pathway & Disease-focused RT2 Profiler PCR Array including ARC: 
              Synaptic Plasticity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ARC
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    QuantiFast Probe-based Assays in human, mouse, rat ARC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ARC gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arc1 , 5 activity regulated cytoskeletal-associated protein1, 5 85.77(n)1
    92.93(a)1
      15 (34.25 cM)5
    118381  NM_018790.31  NP_061260.11 
     746690835 
    chicken
    (Gallus gallus)
    Aves ARC1 activity-regulated cytoskeleton-associated protein 70.78(n)
    73.01(a)
      395075  NM_204432.1  NP_989763.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARC6
    activity-regulated cytoskeleton-associated protein...
    68(a)
    1 ↔ 1
    GL343222.1(1950930-1952159)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia arc1 activity-regulated cytoskeleton-associated protein 54.06(n)
    46.33(a)
      100271754  XM_004918927.1  XP_004918984.1 


    ENSEMBL Gene Tree for ARC (if available)
    TreeFam Gene Tree for ARC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARC (see all 134)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1916872121,2
    --143691916(+) GTTCAA/TGATCT 1 -- ds50010--------
    rs780652081,2
    C,F--143691987(+) GGCTCC/TGGAGC 1 -- ds50011Minor allele frequency- T:0.14WA 118
    rs1835253651,2
    --143692073(+) GACTTA/GCAGAG 1 -- ds50010--------
    rs132529811,2
    C,F--143692087(+) CAGGCC/ATGAGC 1 -- ds500110Minor allele frequency- A:0.14WA NA CSA EA 371
    rs1452581831,2
    --143692146(+) CACCTC/TGGGCC 1 -- ds50010--------
    rs1449841801,2
    --143692249(+) CAGGAA/CCCTGA 1 -- ds50010--------
    rs360444741,2
    C,F--143692326(+) AGGGTC/GACCCT 1 -- ds500110Minor allele frequency- G:0.49NA WA CSA EA 370
    rs1487521341,2
    --143692338(+) TGGGCC/TGGGGG 1 -- ds50010--------
    rs132608131,2
    C,F,H--143692395(+) AAACAA/CCATGA 1 -- ds500120Minor allele frequency- C:0.25NS EA NA WA 2344
    rs1882138191,2
    --143692419(+) TTTCAA/GTGTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ARC (143692405 - 143696833 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ARC:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2661137CNV Deletion23128226
    dgv7913n71CNV Loss21882294
    dgv904n27CNV Loss19166990
    nsv470245CNV Loss18288195
    dgv7910n71CNV Loss21882294
    dgv7915n71CNV Loss21882294
    dgv7916n71CNV Loss21882294
    dgv7914n71CNV Loss21882294
    nsv891626CNV Gain21882294

    Human Gene Mutation Database (HGMD): ARC
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARC
    DNA2.0 Custom Variant and Variant Library Synthesis for ARC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612461    OMIM disorders: --

    10 diseases for ARC:    
    About MalaCards
    myoclonus, familial cortical    idiopathic generalized epilepsy    neuroblastoma    myopathy
    mental retardation    hiv-1    cerebritis    alzheimer's disease
    neuronitis    leukemia


    ARC for disorders           About GeneDecksing


    Export disorders for ARC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARC gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with ARC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutation screening of the chromosome 8q24.3-human activity-regulated cytoskeleton-associated gene (ARC) in idiopathic generalized epilepsy. (PubMed id 10970730)1, 2, 3, 9 Haug K.... Heils A. (Mol. Cell. Probes 2000)
    2. Activity-regulated cytoskeleton-associated protein Arc/Arg3.1 binds to spectrin and associates with nuclear promyelocytic leukemia (PML) bodies. (PubMed id 17466953)1, 3, 9 Bloomer W.A....VanDongen A.M. (Brain Res. 2007)
    3. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PubMed id 21834987)1, 2 Bai S.W.... Ridley A.J. (BMC Biol. 2011)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T.... Nomura N. (DNA Res. 1996)
    6. Human activity-regulated cytoskeleton-associated gene (ARC) maps to chromosome 8q24. (PubMed id 11117363)1, 9 Kremerskothen J. and Barnekow A. (Chromosome Res. 2000)
    7. Role of the ubiquitin ligase E6AP/UBE3A in controlling levels of the synaptic protein Arc. (PubMed id 23671107)1 KA1hnle S....Scheffner M. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    8. Balancing Arc synthesis, mRNA decay, and proteasomal degradation: maximal protein expression triggered by rapid eye movement sleep-like bursts of muscarinic cholinergic receptor stimulation. (PubMed id 22584581)1 SoulAc J....Bramham C.R. (J. Biol. Chem. 2012)
    9. Contrast-enhanced magnetic resonance microangiography reveals remodeling of the cerebral microvasculature in transgenic ArcAI^ mice. (PubMed id 22302811)1 Klohs J....Rudin M. (J. Neurosci. 2012)
    10. A novel ARC gene polymorphism is associated with reduced risk of Alzheimer's disease. (PubMed id 22622366)1 Landgren S....Kettunen P. (J Neural Transm 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23237 HGNC: 648 AceView: ARC Ensembl:ENSG00000198576 euGenes: HUgn23237
    ECgene: ARC Kegg: 23237 H-InvDB: ARC

    (According to HUGE)
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    HUGE: KIAA0278

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for ARC gene:
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    GeneCards and IP:
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