Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARC Gene

protein-coding   GIFtS: 55
GCID: GC08M143690

Activity-Regulated Cytoskeleton-Associated Protein

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Activity-Regulated Cytoskeleton-Associated Protein1 2
Activity-Regulated Gene 3.1 Protein Homolog2 3
ARC/ARG3.12 3
Arg3.12 3
KIAA02783 5

External Ids:    HGNC: 6481   Entrez Gene: 232372   Ensembl: ENSG000001985767   OMIM: 6124615   UniProtKB: Q7LC443   

Export aliases for ARC gene to outside databases

Previous GC identifers: GC08U990084 GC08M143591 GC08M138948


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ARC Gene: 
ARC (activity-regulated cytoskeleton-associated protein) is a protein-coding gene. Diseases associated with ARC include idiopathic generalized epilepsy, and myopathy, and among its related super-pathways are Cocaine addiction and PGC1Alpha Pathway.

UniProtKB/Swiss-Prot: ARC_HUMAN, Q7LC44
Function: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates
endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA
receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization.
Required in the stress fiber dynamics and cell migration




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARC gene promoter:
         Sp1   NRSF form 1   STAT5A   NRSF form 2   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARC promoter sequence
   Search SABiosciences Chromatin IP Primers for ARC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

ARC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARC gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M143690:  view genomic region     (about GC identifiers)

Start:
143,692,405 bp from pter      End:
143,696,833 bp from pter
Size:
4,429 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARC_HUMAN, Q7LC44 (See protein sequence)
Recommended Name: Activity-regulated cytoskeleton-associated protein  
Size: 396 amino acids; 45316 Da
Subunit: Interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 and DNM2/DYN2 (By similarity)
Subcellular location: Cytoplasm, cytoskeleton (By similarity). Endosome (By similarity). Cytoplasmic vesicle,
secretory vesicle, acrosome (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic
density (By similarity). Cell projection, dendrite (By similarity). Cell projection, dendritic spine (By
similarity). Cell junction, synapse (By similarity). Note=Associated with the cell cortex of neuronal soma and
dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail (By similarity).
Enriched on the plasma membrane
Sequence caution: Sequence=BAA19667.1; Type=Erroneous initiation;
Secondary accessions: Q9UJW6 Q9Y469

Explore the universe of human proteins at neXtProt for ARC: NX_Q7LC44

Explore proteomics data for ARC at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7LC44

  • ARC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARC Protein Expression
    REFSEQ proteins: NP_056008.1  
    ENSEMBL proteins: 
     ENSP00000349022  

    Human Recombinant Protein Products for ARC: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ARC
    OriGene Protein Over-expression Lysate for ARC
    OriGene MassSpec for ARC 
    OriGene Custom Protein Services for ARC
    GenScript Custom Purified and Recombinant Proteins Services for ARC
    Novus Biologicals ARC Proteins
    Novus Biologicals ARC Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ARC 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005737cytoplasm IDA--
    GO:0005768endosome IEA--
    GO:0005886plasma membrane IDA--
    GO:0014069postsynaptic density IEA--

    ARC for ontologies           About GeneDecksing



    ARC Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ARC
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ARC
    GenScript Superior Antibodies for ARC
    Novus Biologicals ARC Antibodies
    Abcam antibodies for ARC
    Cloud-Clone Corp. Antibodies for ARC 
    ThermoFisher Antibodies for ARC
    LSBio Antibodies in human, mouse, rat for ARC 

    Assay Products for ARC: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ARC
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARC
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ARC 
    Cloud-Clone Corp. CLIAs for ARC


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR023263 Activity-reg_cytoskelet-assoc

    Graphical View of Domain Structure for InterPro Entry Q7LC44

    ProtoNet protein and cluster: Q7LC44

    UniProtKB/Swiss-Prot: ARC_HUMAN, Q7LC44
    Similarity: Belongs to the ARC/ARG3.1 family


    ARC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARC_HUMAN, Q7LC44
    Function: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates
    endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA
    receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization.
    Required in the stress fiber dynamics and cell migration

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    ARC for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Arc):
     behavior/neurological  embryogenesis  growth/size  mortality/aging  nervous system 
     no phenotypic analysis 

    ARC for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ARC: Arctm1.1Kuhl Arctm1Amt

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ARC 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ARC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARC 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARC 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARC
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate ARC (see all 17):
    hsa-miR-495 hsa-miR-600 hsa-miR-3194-5p hsa-miR-1321 hsa-miR-520d-5p hsa-miR-769-5p hsa-miR-7-2* hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidARC 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ARC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARC

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ARC
    Sirion Biotech Customized adenovirus for overexpression of ARC

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ARC (see all 6)
    OriGene ORF clones in mouse, rat for ARC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ARC (NM_001142281)
    Sino Biological Human cDNA Clone for ARC
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARC
    Sirion Biotech Customized lentivirus for stable overexpression of ARC 
                         Customized lentivirus expression plasmids for stable overexpression of ARC 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ARC
    Search LifeMap BioReagents cell lines for ARC
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARC


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARC About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Amphetamine addiction
    Amphetamine addiction0.44
    2PEDF Induced Signaling
    Glucocorticoid Receptor Signaling0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ARC
        Glucocorticoid Receptor Signaling



    1         Kegg Pathway  (Kegg details for ARC):
        Amphetamine addiction


    ARC for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/20 Interacting proteins for ARC (Q7LC442, 3 ENSP000003490224) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRT15P190122, 3, ENSP000002540434MINT-67831 I2D: score=5 STRING: ENSP00000254043
    GRIN1Q055863, ENSP000003606164I2D: score=1 STRING: ENSP00000360616
    GRIN2BQ132243, ENSP000002795934I2D: score=1 STRING: ENSP00000279593
    CYFIP1Q7L5763, ENSP000003245494I2D: score=1 STRING: ENSP00000324549
    DLG4P783523I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--
    GO:0007010cytoskeleton organization IMP--
    GO:0007492endoderm development IEA--
    GO:0007612learning IEA--
    GO:0009952anterior/posterior pattern specification IEA--

    ARC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ARC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARC

    3 Novoseek inferred chemical compound relationships for ARC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nmda 27.5 3 12559831 (1), 18614031 (1)
    tyrosine 1.45 3 11880195 (2), 14969744 (1)
    dopamine 0 1 16908598 (1)

    Search CenterWatch for drugs/clinical trials and news about ARC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARC gene: 
    NM_015193.4  

    Unigene Cluster for ARC:

    Activity-regulated cytoskeleton-associated protein
    Hs.40888  [show with all ESTs]
    Unigene Representative Sequence: BC075802
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356613(uc003ywn.1) ENST00000581404

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARC
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate ARC (see all 17):
    hsa-miR-495 hsa-miR-600 hsa-miR-3194-5p hsa-miR-1321 hsa-miR-520d-5p hsa-miR-769-5p hsa-miR-7-2* hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidARC 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ARC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARC
    Clone
    Products:
         
    OriGene clones in human, mouse for ARC (see all 6)
    OriGene ORF clones in mouse, rat for ARC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ARC (NM_001142281)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARC
    Sirion Biotech Customized lentivirus for stable overexpression of ARC 
                         Customized lentivirus expression plasmids for stable overexpression of ARC 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ARC
    OriGene qSTAR qPCR primer pairs in human, mouse for ARC
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARC
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARC

    Additional mRNA sequence: 

    AF193421.1 BC012321.1 BC075802.1 D87468.1 

    2 DOTS entries:

    DT.105171  DT.95264726 

    24/40 AceView cDNA sequences (see all 40):

    AI972927 CB154449 BC012321 BG054976 AI498494 BG339449 BG056647 BE795019 
    BE797482 BF312181 AI399718 BQ013642 CB156410 BG058542 BE855583 BI116320 
    AF193421 BC075802 BF525603 BI197943 D87468 AW015459 BG056710 BF338615 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARC expression in normal human tissues (normalized intensities)      ARC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGCTGTGGC
    ARC Expression
    About this image


    ARC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 18 entries
             Thalamus
             Septum   
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             S-shaped Body
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Breast (Uncategorized)
             breast stroma   

    See ARC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARC

    SOURCE GeneReport for Unigene cluster: Hs.40888
        SABiosciences Expression via Pathway-Focused PCR Array including ARC: 
              Synaptic Plasticity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ARC
    OriGene qSTAR qPCR primer pairs in human, mouse for ARC
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARC
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARC
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ARC gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arc1 , 5 activity regulated cytoskeletal-associated protein1, 5 85.77(n)1
    92.93(a)1
      15 (34.25 cM)5
    118381  NM_018790.21  NP_061260.11 
     746690835 
    chicken
    (Gallus gallus)
    Aves ARC1 activity-regulated cytoskeleton-associated protein 70.78(n)
    73.01(a)
      395075  NM_204432.1  NP_989763.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARC6
    Uncharacterized protein
    67(a)
    1 ↔ 1
    GL343222.1(1950930-1952159)


    ENSEMBL Gene Tree for ARC (if available)
    TreeFam Gene Tree for ARC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/134 SNPs in ARC are shown (see all 134)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1916872121,2
    --143691916(+) GTTCAA/TGATCT 1 -- ds50010--------
    rs780652081,2
    C,F--143691987(+) GGCTCC/TGGAGC 1 -- ds50011Minor allele frequency- T:0.14WA 118
    rs1835253651,2
    --143692073(+) GACTTA/GCAGAG 1 -- ds50010--------
    rs132529811,2
    C,F--143692087(+) CAGGCC/ATGAGC 1 -- ds500110Minor allele frequency- A:0.14WA NA CSA EA 371
    rs1452581831,2
    --143692146(+) CACCTC/TGGGCC 1 -- ds50010--------
    rs1449841801,2
    --143692249(+) CAGGAA/CCCTGA 1 -- ds50010--------
    rs360444741,2
    C,F--143692326(+) AGGGTC/GACCCT 1 -- ds500110Minor allele frequency- G:0.49NA WA CSA EA 370
    rs1487521341,2
    --143692338(+) TGGGCC/TGGGGG 1 -- ds50010--------
    rs132608131,2
    C,F,H--143692395(+) AAACAA/CCATGA 1 -- ds500120Minor allele frequency- C:0.25NS EA NA WA 2344
    rs1882138191,2
    --143692419(+) TTTCAA/GTGTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ARC (143692405 - 143696833 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ARC:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2661137CNV Deletion23128226
    dgv7913n71CNV Loss21882294
    dgv904n27CNV Loss19166990
    nsv470245CNV Loss18288195
    dgv7910n71CNV Loss21882294
    dgv7915n71CNV Loss21882294
    dgv7916n71CNV Loss21882294
    dgv7914n71CNV Loss21882294
    nsv891626CNV Gain21882294


    Human Gene Mutation Database (HGMD): ARC
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ARC
    DNA2.0 Custom Variant and Variant Library Synthesis for ARC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612461    OMIM disorders: --

    8 diseases for ARC:    About MalaCards
    idiopathic generalized epilepsy    myopathy    neuroblastoma    mental retardation
    cerebritis    neuronitis    alzheimer's disease    leukemia


    ARC for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for ARC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARC gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with ARC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutation screening of the chromosome 8q24.3-human activity-regulated cytoskeleton-associated gene (ARC) in idiopathic generalized epilepsy. (PubMed id 10970730)1, 2, 3, 9 Haug K.... Heils A. (2000)
    2. Activity-regulated cytoskeleton-associated protein Arc/Arg3.1 binds to spectrin and associates with nuclear promyelocytic leukemia (PML) bodies. (PubMed id 17466953)1, 3, 9 Bloomer W.A....VanDongen A.M. (2007)
    3. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PubMed id 21834987)1, 2 Bai S.W.... Ridley A.J. (2011)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T....Nomura N. (1996)
    6. Human activity-regulated cytoskeleton-associated gene (ARC) maps to chromosome 8q24. (PubMed id 11117363)1, 9 Kremerskothen J. and Barnekow A. (2000)
    7. Role of the ubiquitin ligase E6AP/UBE3A in controlling levels of the synaptic protein Arc. (PubMed id 23671107)1 Kuhnle S....Scheffner M. (2013)
    8. Balancing Arc synthesis, mRNA decay, and proteasomal degradation: maximal protein expression triggered by rapid eye movement sleep-lik e bursts of muscarinic cholinergic receptor stimulation. (PubMed id 22584581)1 Soule J....Bramham C.R. (2012)
    9. Contrast-enhanced magnetic resonance microangiography reveals remodeling of the cerebral microvasculature in transgenic ArcAb mice. (PubMed id 22302811)1 Klohs J....Rudin M. (2012)
    10. A novel ARC gene polymorphism is associated with reduc ed risk of Alzheimer's disease. (PubMed id 22622366)1 Landgren S....Kettunen P. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23237 HGNC: 648 AceView: ARC Ensembl:ENSG00000198576 euGenes: HUgn23237
    ECgene: ARC Kegg: 23237 H-InvDB: ARC

    (According to HUGE)
    About This Section
    HUGE: KIAA0278

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARC gene:
    Search GeneIP for patents involving ARC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ARC
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ARC  
     OriGene qPCR primer pairs and template standards for ARC   OriGene Protein Over-expression Lysate for ARC  
     OriGene MassSpec something-or-other for ARC   OriGene clones in human, mouse for ARC  
     OriGene qSTAR qPCR primer pairs in human, mouse for ARC   OriGene Purified Protein for ARC  
     OriGene ORF clones in mouse, rat for ARC   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ARC   OriGene Custom Protein Services for ARC  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARC
     QIAGEN SeqTarget long-range PCR primers for resequencing ARC
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARC
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARC
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARC
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARC
     GenScript Custom Purified and Recombinant Proteins Services for ARC GenScript cDNA clones with any tag delivered in your preferred vector for ARC
     GenScript Custom Assay Services for ARC GenScript Superior Antibodies for ARC
     GenScript Custom overexpressing Cell Line Services for ARC CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ARC promoter
     Search Chromatin IP Primers for ARC
     RT2 qPCR Primer Assay in human, mouse, rat ARC
     GNC Network for ARC
     SABiosciences PCR Arrays including human, mouse, rat ARC
     Search Tocris compounds for ARC
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for ARC
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ARC antibodies
     ARC proteins
     ARC lysates
     Antibodies for ARC
     See all of Abcam's Antibodies, Kits and Proteins for ARC
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ARC
     Antibodies for ARC
     ELISAs for ARC
     CLIAs for ARC
     Search LifeMap BioReagents cell lines for ARC
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARC
     SwitchGear 3'UTR luciferase reporter plasmids for ARC
     SwitchGear Promoter luciferase reporter plasmids for ARC
     ThermoFisher Antibodies for ARC
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARC
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ARC
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ARC
    Customized:
     lentivirus for stable overexpression of ARC
     lentivirus expression plasmids for stable overexpression of ARC
     adenovirus for overexpression of ARC
     LSBio Antibodies in human, mouse, rat for ARC
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ARC gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4