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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARC Gene

protein-coding   GIFtS: 53
GCID: GC08M143690

activity-regulated cytoskeleton-associated protein
 Explore 8 diseases affiliated with
ARC via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ARC    

Aliases
for ARC gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Activity-Regulated Cytoskeleton-Associated Protein1 2
Arg3.11 2 3
KIAA02781 3 5
Activity-Regulated Gene 3.1 Protein Homolog2 3
ARC/ARG3.12 3

External Ids:    HGNC: 6481   Entrez Gene: 232372   Ensembl: ENSG000001985767   OMIM: 6124615   UniProtKB: Q7LC443   

Export aliases for ARC gene to outside databases

Previous GC identifers: GC08U990084 GC08M143591 GC08M138948


Summaries
for ARC gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ARC_HUMAN, Q7LC44
Function: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates
endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA
receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required
in the stress fiber dynamics and cell migration




Genomic Views
for ARC gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARC gene promoter:
         Sp1   NRSF form 1   STAT5A   NRSF form 2   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ARC promoter sequence
   Search SABiosciences Chromatin IP Primers for ARC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

ARC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARC gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M143690:  view genomic region     (about GC identifiers)

Start:
 143,692,405 bp from pter      End:
 143,696,833 bp from pter
Size:
 4,429 bases      Orientation:
 minus strand

Proteins
for ARC gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ARC_HUMAN, Q7LC44 (See protein sequence)
Recommended Name: Activity-regulated cytoskeleton-associated protein  
Size: 396 amino acids; 45316 Da
Subunit: Interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 and DNM2/DYN2 (By similarity)
Subcellular location: Cytoplasm, cytoskeleton (By similarity). Endosome (By similarity). Cytoplasmic vesicle, secretory
vesicle, acrosome (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By
similarity). Cell projection, dendrite (By similarity). Cell projection, dendritic spine (By similarity). Cell
junction, synapse (By similarity). Note=Associated with the cell cortex of neuronal soma and dendrites. Enriched in
postsynaptic density of dendritic spines. Associated with the sperm tail (By similarity). Enriched on the plasma
membrane
Sequence caution: Sequence=BAA19667.1; Type=Erroneous initiation;
Secondary accessions: Q9UJW6 Q9Y469

Explore the universe of human proteins at neXtProt for ARC: NX_Q7LC44

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7LC44

    • ARC Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_056008.1  
    ENSEMBL proteins: 
     ENSP00000349022  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: ARC
    OriGene Protein Over-expression Lysate: ARC
    OriGene Custom Protein Services for ARC 
    GenScript Custom Purified and Recombinant Proteins Services for ARC
    Novus Biologicals ARC Proteins
    Novus Biologicals ARC Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ARC

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005737cytoplasm IDA--
    GO:0005768endosome IEA--
    GO:0005886plasma membrane IDA--
    GO:0014069postsynaptic density IEA--


    ARC for ontologies           About GeneDecksing



    ARC Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ARC
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    Search for Antibodies for ARC at Abcam  
    Uscn Antibodies for ARC
    ThermoFisher Antibodies for ARC

    Assay Products for ARC: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARC
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ARC

    Protein Domains /
    Families
    for ARC gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ARC for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR023263 Activity-reg_cytoskelet-assoc

    Graphical View of Domain Structure for InterPro Entry Q7LC44

    ProtoNet protein and cluster: Q7LC44

    UniProtKB/Swiss-Prot: ARC_HUMAN, Q7LC44
    Similarity: Belongs to the ARC/ARG3.1 family


    Function
    for ARC gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ARC_HUMAN, Q7LC44
    Function: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates
    endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA
    receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required
    in the stress fiber dynamics and cell migration

    miRNA
    Products:            		 OriGene 3'-UTR Clone: ARC
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARC
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate ARC (see all 17):
    hsa-miR-495 hsa-miR-600 hsa-miR-3194-5p hsa-miR-1321 hsa-miR-520d-5p hsa-miR-769-5p hsa-miR-7-2* hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmid: ARC 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARC (see all 7)
    OriGene shRNA RFP: ARC
    OriGene siRNA: ARC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARC

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ARC

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARC (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARC (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): ARC (NM_001142281)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARC 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ARC
    Search LifeMap BioReagents cell lines for ARC

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARC

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----


    ARC for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for ARC: Arctm1.1Kuhl Arctm1Amt
         5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Arc):
     behavior/neurological  embryogenesis  growth/size  mortality/aging  nervous system 

    ARC for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ARC gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    		Glucocorticoid Receptor Signaling0.27

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ARC
        Glucocorticoid Receptor Signaling


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/20 Interacting proteins for ARC (Q7LC442, 3 ENSP000003490224) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRT15P190122, 3, ENSP000002540434MINT-67831 I2D: score=5 STRING: ENSP00000254043
    GRIN1Q055863, ENSP000003606164I2D: score=1 STRING: ENSP00000360616
    GRIN2BQ132243, ENSP000002795934I2D: score=1 STRING: ENSP00000279593
    CYFIP1Q7L5763, ENSP000003245494I2D: score=1 STRING: ENSP00000324549
    DLG4P783523I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--
    GO:0007010cytoskeleton organization IMP--
    GO:0007492endoderm development IEA--
    GO:0007612learning IEA--
    GO:0009952anterior/posterior pattern specification IEA--


    ARC for ontologies           About GeneDecksing



    Drugs & Compounds
    for ARC gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ARC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARC
    3 Novoseek chemical compound relationships for ARC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nmda 27.5 3 12559831 (1), 18614031 (1)
    tyrosine 1.45 3 11880195 (2), 14969744 (1)
    dopamine 0 1 16908598 (1)

    Search CenterWatch for drugs/clinical trials and news about ARC 

    Transcripts
    for ARC gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ARC gene: 
    NM_015193.4  

    Unigene Cluster for ARC:

    Activity-regulated cytoskeleton-associated protein
    Hs.40888  [show with all ESTs]
    Unigene Representative Sequence: BC075802
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356613(uc003ywn.1) ENST00000581404

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ARC
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARC
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate ARC (see all 17):
    hsa-miR-495 hsa-miR-600 hsa-miR-3194-5p hsa-miR-1321 hsa-miR-520d-5p hsa-miR-769-5p hsa-miR-7-2* hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmid: ARC 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARC (see all 7)
    OriGene shRNA RFP: ARC
    OriGene siRNA: ARC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARC
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARC (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARC (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): ARC (NM_001142281)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARC 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARC
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARC
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARC

    Additional cDNA sequence: 

    AF193421.1 BC012321.1 BC075802.1 D87468.1 

    2 DOTS entries:

    DT.105171  DT.95264726 

    24/40 AceView cDNA sequences (see all 40):

    BC012321 CB154449 BG054976 AI972927 BG056710 D87468 AI399718 BI197943 
    BG339449 BF338615 NM_015193 BG056647 AF193421 BF525603 BF312181 BQ013642 
    BG058542 BC075802 CB156410 BE795019 BE855583 AI498494 AW015459 BI752734 

    GeneLoc Exon Structure


    Expression
    for ARC gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGCTGTGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ARC expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerGABAergic Amacrine CellsAmacrine, Retina
    PancreasDorsal Pancreatic BudImmature Beta Progenitor CellsPancreas
    PancreasVentral Pancreatic BudImmature Beta Progenitor CellsPancreas
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ARC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARC

    SOURCE GeneReport for Unigene cluster: Hs.40888
        SABiosciences Expression via Pathway-Focused PCR Array including ARC: 
              Synaptic Plasticity in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARC

    Orthologs
    for ARC gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ARC gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Arc1 , 5 activity regulated cytoskeletal-associated protein1, 5 85.77(n)1
    92.93(a)1    		   15 (34.25 cM)5
    118381  NM_018790.21  NP_061260.11 
     746690835 
    chicken
    (Gallus gallus)    		 Aves ARC1 activity-regulated cytoskeleton-associated protein 70.78(n)
    73.01(a)    		   395075  NM_204432.1  NP_989763.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ARC6
    		 --
    		 69(a)
    		 1 ↔ 1
    		 GL343222.1(1950960-1952159)


    ENSEMBL Gene Tree for ARC (if available)
    TreeFam Gene Tree for ARC (if available) 

    Paralogs
    for ARC gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for ARC gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/96 NCBI SNPs in ARC are shown (see all 96)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1916872121,2
    		--143691916(+) GTTCAA/TGATCT 1 -- ds50010--------
    rs780652081,2
    		C,F,--143691987(+) GGCTCC/TGGAGC 1 -- ds50011Minor allele frequency- T:0.14WA 118
    rs1835253651,2
    		--143692073(+) GACTTA/GCAGAG 1 -- ds50010--------
    rs132529811,2
    		C,F,--143692087(+) CAGGCC/ATGAGC 1 -- ds500110Minor allele frequency- A:0.14WA NA CSA EA 371
    rs1452581831,2
    		--143692146(+) CACCTC/TGGGCC 1 -- ds50010--------
    rs1449841801,2
    		--143692249(+) CAGGAA/CCCTGA 1 -- ds50010--------
    rs360444741,2
    		C,F,--143692326(+) AGGGTC/GACCCT 1 -- ds500110Minor allele frequency- G:0.49NA WA CSA EA 370
    rs1487521341,2
    		--143692338(+) TGGGCC/TGGGGG 1 -- ds50010--------
    rs132608131,2
    		C,F,H,--143692395(+) AAACAA/CCATGA 1 -- ds500120Minor allele frequency- C:0.25NS EA NA WA 2344
    rs1882138191,2
    		--143692419(+) TTTCAA/GTGTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ARC (143692405 - 143696833 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ARC
         2 CNVs: 53348 30296
    Human Gene Mutation Database (HGMD): ARC

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARC
    DNA2.0 Custom Variant and Variant Library Synthesis for ARC

    Disorders / Diseases
    for ARC gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ARC for disorders           About GeneDecksing

    OMIM gene information: 612461    OMIM disorders: --

    8 diseases for ARC:    About MalaCards
    idiopathic generalized epilepsy    generalized epilepsy    mental retardation syndrome    neurodegenerative disease
    myopathy    neuroblastoma    leukemia    neuronitis


    Export disorders for ARC gene to outside databases

    Publications
    for ARC gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARC gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with ARC)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutation screening of the chromosome 8q24.3-human activity-regulated cytoskeleton-associated gene (ARC) in idiopathic generalized epilepsy. (PubMed id 10970730)1, 2, 3, 9 Haug K.... Heils A. (2000)
    2. Activity-regulated cytoskeleton-associated protein Arc/Arg3.1 binds to spectrin and associates with nuclear promyelocytic leukemia (PML) bodies. (PubMed id 17466953)1, 3, 9 Bloomer W.A....VanDongen A.M. (2007)
    3. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PubMed id 21834987)1, 2 Bai S.W.... Ridley A.J. (2011)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T....Nomura N. (1996)
    6. Human activity-regulated cytoskeleton-associated gene (ARC) maps to chromosome 8q24. (PubMed id 11117363)1, 9 Kremerskothen J. and Barnekow A. (2000)
    7. Balancing Arc synthesis, mRNA decay, and proteasomal degradation: maximal protein expression triggered by rapid eye movement sleep-lik e bursts of muscarinic cholinergic receptor stimulation. (PubMed id 22584581)1 Soule J....Bramham C.R. (2012)
    8. Contrast-enhanced magnetic resonance microangiography reveals remodeling of the cerebral microvasculature in transgenic ArcAb mice. (PubMed id 22302811)1 Klohs J....Rudin M. (2012)
    9. A novel ARC gene polymorphism is associated with reduc ed risk of Alzheimer's disease. (PubMed id 22622366)1 Landgren S....Kettunen P. (2012)
    10. Arc/Arg3.1 regulates an endosomal pathway essential f or activity-dependent I^-amyloid generation. (PubMed id 22036569)1 Wu J....Worley P.F. (2011)

    External Searches for ARC gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    Genome Databases showing ARC gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23237 HGNC: 648 AceView: ARC Ensembl:ENSG00000198576 euGenes: HUgn23237
    ECgene: ARC H-InvDB: ARC

    Other Databases showing ARC gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0278

    Specialized Databases showing ARC gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARC Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ARC gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ARC gene:
    Search GeneIP for patents involving ARC

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