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ARC Gene(Protein Coding)

Activity Regulated Cytoskeleton Associated Protein

GCID:
GC08M142611
GIFtS:
54
Genes Participants
UDN Logo

Aliases for ARC Gene

Aliases for ARC Gene

  • Activity Regulated Cytoskeleton Associated Protein 2 3 5
  • Activity-Regulated Gene 3.1 Protein Homolog 3 4
  • ARC/ARG3.1 3 4
  • Arg3.1 3 4
  • Activity-Regulated Cytoskeleton-Associated Protein 3
  • KIAA0278 4

External Ids for ARC Gene

Previous GeneCards Identifiers for ARC Gene

  • GC08U990084
  • GC08M143591
  • GC08M143690
  • GC08M138948

Summaries for ARC Gene

GeneCards Summary for ARC Gene

ARC (Activity Regulated Cytoskeleton Associated Protein) is a Protein Coding gene. Diseases associated with ARC include Amphetamine Abuse and Anterograde Amnesia. Among its related pathways are PEDF Induced Signaling and Neuroscience.

UniProtKB/Swiss-Prot for ARC Gene

  • Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARC Gene

Genomics for ARC Gene

Products:

  1. Regulatory Element

Regulatory Elements for ARC Gene

Enhancers for ARC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G142608 1.1 Ensembl ENCODE 7.5 +5.5 5528 1.7 ELF3 HDAC1 PKNOX1 NFIB SIN3A RAD21 GLIS2 ELK1 EGR1 SCRT2 ARC JRK LOC101928087 MROH4P
GH08G142614 1 ENCODE 6.3 -0.4 -363 1.6 HDGF AGO1 SIN3A GLIS2 ELK1 FOS ZNF263 SP3 YY2 REST JRK ZNF696 ARC LOC101928087 ENSG00000261044
GH08G142599 0.6 ENCODE 0.4 +15.0 14958 0.2 RING1 ZGPAT RFX1 DMAP1 BMI1 EP300 JRK ZNF696 ARC MROH4P
GH08G142597 0.4 ENCODE 0.4 +16.9 16878 0.2 GATA3 JRK MROH4P ARC
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARC on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ARC gene promoter:

Genomic Location for ARC Gene

Chromosome:
8
Start:
142,611,044 bp from pter
End:
142,614,472 bp from pter
Size:
3,429 bases
Orientation:
Minus strand

Genomic View for ARC Gene

Genes around ARC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARC Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ARC Gene

Proteins for ARC Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ARC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7LC44-ARC_HUMAN
    Recommended name:
    Activity-regulated cytoskeleton-associated protein
    Protein Accession:
    Q7LC44
    Secondary Accessions:
    • Q9UJW6
    • Q9Y469

    Protein attributes for ARC Gene

    Size:
    396 amino acids
    Molecular mass:
    45316 Da
    Quaternary structure:
    • Interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 and DNM2/DYN2.
    SequenceCaution:
    • Sequence=BAA19667.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ARC Gene

Protein Expression for ARC Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ARC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARC Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ARC (ARG3.1)

No data available for DME Specific Peptides for ARC Gene

Domains & Families for ARC Gene

Gene Families for ARC Gene

HGNC:

Protein Domains for ARC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ARC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7LC44

UniProtKB/Swiss-Prot:

ARC_HUMAN :
  • Belongs to the ARC/ARG3.1 family.
Family:
  • Belongs to the ARC/ARG3.1 family.
genes like me logo Genes that share domains with ARC: view

Function for ARC Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for ARC Gene

UniProtKB/Swiss-Prot Function:
Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration.
genes like me logo Genes that share phenotypes with ARC: view

Animal Models for ARC Gene

MGI Knock Outs for ARC:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARC Gene

Localization for ARC Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARC Gene

Cytoplasm, cytoskeleton. Endosome. Cytoplasmic vesicle, secretory vesicle, acrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse. Note=Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail (By similarity). Enriched on the plasma membrane. {ECO:0000250, ECO:0000269 PubMed:21834987}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARC gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3
nucleus 3
endosome 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ARC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005737 cytoplasm IEA,IDA 21834987
GO:0005768 endosome IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA,IDA 21834987
genes like me logo Genes that share ontologies with ARC: view

Pathways & Interactions for ARC Gene

genes like me logo Genes that share pathways with ARC: view

Pathways by source for ARC Gene

2 Cell Signaling Technology pathways for ARC Gene
1 BioSystems pathway for ARC Gene
1 KEGG pathway for ARC Gene
1 Qiagen pathway for ARC Gene

Gene Ontology (GO) - Biological Process for ARC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0007010 cytoskeleton organization IMP 21834987
GO:0007275 multicellular organism development IEA --
GO:0007492 endoderm development IEA --
GO:0007612 learning IEA --
genes like me logo Genes that share ontologies with ARC: view

No data available for SIGNOR curated interactions for ARC Gene

Drugs & Compounds for ARC Gene

Products:

  1. Drug

(11) Drugs for ARC Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Captopril Approved Pharma Inhibition, Inhibitor ACE inhibitor, ACE inhibitor; also inhibits LTA4 hydrolase 34
rituximab Approved Pharma Therapeutic Antibodies 1692
Angiotensin-Converting Enzyme Inhibitors Pharma 724
Antibodies Pharma 6394
Antihypertensive Agents Pharma 4207
genes like me logo Genes that share compounds with ARC: view

Transcripts for ARC Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for ARC Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(40) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARC Gene

Activity-regulated cytoskeleton-associated protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARC Gene

No ASD Table

Relevant External Links for ARC Gene

GeneLoc Exon Structure for
ARC
ECgene alternative splicing isoforms for
ARC

Expression for ARC Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARC Gene

mRNA expression in normal human tissues for ARC Gene
mRNA expression by BioGPS for ARC GenemRNA expression by GTEx for ARC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARC Gene

This gene is overexpressed in Pituitary (x5.7) and Brain - Cortex (x5.1).

Protein differential expression in normal tissues from HIPED for ARC Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARC Gene



Protein tissue co-expression partners for ARC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARC Gene:

ARC

SOURCE GeneReport for Unigene cluster for ARC Gene:

Hs.40888

Evidence on tissue expression from TISSUES for ARC Gene

  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with ARC: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARC Gene

Orthologs for ARC Gene

This gene was present in the common ancestor of chordates.

Orthologs for ARC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ARC 34 35
  • 99.43 (n)
cow
(Bos Taurus)
 Mammalia ARC 34 35
  • 89.98 (n)
rat
(Rattus norvegicus)
 Mammalia Arc 34
  • 86.2 (n)
mouse
(Mus musculus)
 Mammalia Arc 34 16 35
  • 85.77 (n)
oppossum
(Monodelphis domestica)
 Mammalia ARC 35
  • 77 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia ARC 35
  • 77 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves ARC 34 35
  • 70.78 (n)
lizard
(Anolis carolinensis)
 Reptilia ARC 35
  • 68 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia arc 34
  • 54.06 (n)
Species where no ortholog for ARC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ARC Gene

ENSEMBL:
Gene Tree for ARC (if available)
TreeFam:
Gene Tree for ARC (if available)

Paralogs for ARC Gene

No data available for Paralogs for ARC Gene

Variants for ARC Gene

Sequence variations from dbSNP and Humsavar for ARC Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000029399 -- 142,614,156(+) GCTCC(A/C)GCATC reference, missense
rs1000233723 -- 142,612,799(+) GCTGG(C/G)GTGTT utr-variant-3-prime
rs1003170115 -- 142,615,044(+) GCTTT(C/G)AGCTC upstream-variant-2KB
rs1003242235 -- 142,615,412(+) GAGAG(A/G)GAGAC upstream-variant-2KB
rs1003309256 -- 142,614,821(+) TGCTG(C/T)CTCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARC Gene

Variant ID Type Subtype PubMed ID
dgv12397n54 CNV loss 21841781
dgv7335n100 CNV gain 25217958
dgv904n27 CNV loss 19166990
esv2661137 CNV deletion 23128226
nsv470245 CNV loss 18288195
nsv612709 CNV loss 21841781
nsv950002 CNV deletion 24416366

Variation tolerance for ARC Gene

Residual Variation Intolerance Score: 34.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARC Gene

Human Gene Mutation Database (HGMD)
ARC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARC Gene

Disorders for ARC Gene

MalaCards: The human disease database

(2) MalaCards diseases for ARC Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
amphetamine abuse
anterograde amnesia
  • amnesia, anterograde
- elite association - COSMIC cancer census association via MalaCards
Search ARC in MalaCards View complete list of genes associated with diseases

Relevant External Links for ARC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARC
genes like me logo Genes that share disorders with ARC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARC Gene

Publications for ARC Gene

  1. Mutation screening of the chromosome 8q24.3-human activity-regulated cytoskeleton-associated gene (ARC) in idiopathic generalized epilepsy. (PMID: 10970730) Haug K. … Heils A. (Mol. Cell. Probes 2000) 2 3 4 22 64
  2. Activity-regulated cytoskeleton-associated protein Arc/Arg3.1 binds to spectrin and associates with nuclear promyelocytic leukemia (PML) bodies. (PMID: 17466953) Bloomer W.A. … VanDongen A.M. (Brain Res. 2007) 2 3 22 64
  3. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PMID: 21834987) Bai S.W. … Ridley A.J. (BMC Biol. 2011) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Human activity-regulated cytoskeleton-associated gene (ARC) maps to chromosome 8q24. (PMID: 11117363) Kremerskothen J. … Barnekow A. (Chromosome Res. 2000) 3 22 64

Products for ARC Gene

Sources for ARC Gene

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