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ARAP3 Gene

protein-coding   GIFtS: 55
GCID: GC05M141032

ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain...

(Previous names: centaurin, delta 3)
(Previous symbol: CENTD3)
  Search for ARAP3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 31 2     centaurin-delta-32
CENTD31 2 3 5     cnt-d32
Centaurin, Delta 31 2     Phosphoinositide Binding Protein2
DRAG12     PtdIns(3,4,5)P3-Binding Protein2
Arf And Rho GAP Adapter Protein 32     Centaurin-delta-33
Arf-GAP With Rho-GAP Domain, ANK Repeat And PH Domain-Containing Protein 32     Cnt-d33
ARF-GAP, RHO-GAP, Ankyrin Repeat And Plekstrin Homology Domains-Containing
Protein 32
     

External Ids:    HGNC: 240971   Entrez Gene: 644112   Ensembl: ENSG000001203187   OMIM: 6066475   UniProtKB: Q8WWN83   

Export aliases for ARAP3 gene to outside databases

Previous GC identifers: GC05M140849 GC05M141615 GC05M141016 GC05M141061 GC05M141013 GC05M136177


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARAP3 Gene:
This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin
homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton
and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively
spliced transcript has been found for this gene, but its biological validity has not been determined. (provided
by RefSeq, Sep 2008)

GeneCards Summary for ARAP3 Gene:
ARAP3 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3) is a protein-coding gene. GO annotations related to this gene include ARF GTPase activator activity and phosphatidylinositol-3,4,5-trisphosphate binding. An important paralog of this gene is AGAP5.

UniProtKB/Swiss-Prot: ARAP3_HUMAN, Q8WWN8
Function: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin
cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol
3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate
(PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the
internalization of anthrax toxin

Gene Wiki entry for ARAP3 (CENTD3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ARAP3 gene promoter:
         AhR   LHX3b/Lhx3b   SREBP-1c   MyoD   CUTL1   C/EBPalpha   Arnt   SREBP-1b   SREBP-1a   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARAP3 promoter sequence
   Search Chromatin IP Primers for ARAP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARAP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.3   Ensembl cytogenetic band:  5q31.3   HGNC cytogenetic band: 5q31.3

ARAP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARAP3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M141032:  view genomic region     (about GC identifiers)

Start:
141,032,968 bp from pter      End:
141,061,800 bp from pter
Size:
28,833 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARAP3_HUMAN, Q8WWN8 (See protein sequence)
Recommended Name: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3  
Size: 1544 amino acids; 169844 Da
Subunit: Interacts (via SAM domain) with INPPL1/SHIP2
2 PDB 3D structures from and Proteopedia for ARAP3:
2KG5 (3D)        2LNW (3D)    
Secondary accessions: D3DQE3

Explore the universe of human proteins at neXtProt for ARAP3: NX_Q8WWN8

Explore proteomics data for ARAP3 at MOPED

Post-translational modifications: 

  • Tyrosine phosphorylated at a low basal level. PDGF treatment stimulates phosphorylation. Tyrosine phosphorylation
    is increased in cells that are in the process of becoming attached to a substrate and that start spreading and
    flattening (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARAP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071926.4  
    ENSEMBL proteins: 
     ENSP00000421826   ENSP00000239440   ENSP00000421468   ENSP00000421148  
    Reactome Protein details: Q8WWN8

    ARAP3 Human Recombinant Protein Products:

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    Novus Biologicals ARAP3 Protein
    Novus Biologicals ARAP3 Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ARAP3 

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for ARAP3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    ANKRD: Ankyrin repeat domain containing
    ArfGAP: ADP-ribosylation factor GTPase activating proteins
    SAMD: Sterile alpha motif (SAM) domain containing

    Selected InterPro protein domains (see all 9):
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR001164 ArfGAP
     IPR011993 PH_like_dom
     IPR000159 Ras-assoc

    Graphical View of Domain Structure for InterPro Entry Q8WWN8

    ProtoNet protein and cluster: Q8WWN8

    5 Blocks protein domains:
    IPB000159 RA domain
    IPB000198 RhoGAP domain
    IPB001164 HIV Rev interacting protein signature
    IPB001660 Sterile alpha motif SAM
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: ARAP3_HUMAN, Q8WWN8
    Similarity: Contains 1 Arf-GAP domain
    Similarity: Contains 3 PH domains
    Similarity: Contains 1 Ras-associating domain
    Similarity: Contains 1 Rho-GAP domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Find genes that share domains with ARAP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARAP3_HUMAN, Q8WWN8
    Function: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin
    cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol
    3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate
    (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the
    internalization of anthrax toxin

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005100Rho GTPase activator activity ISS--
    GO:0005515protein binding IPI15090612
    GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding IDA11804589
    GO:0008060ARF GTPase activator activity ISS--
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with ARAP3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ARAP3:
     Decreased focal adhesion (FA)  

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Arap3):
     cardiovascular system  embryogenesis  growth/size/body  integument  mortality/aging 
     nervous system 

    Find genes that share phenotypes with ARAP3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Arap3tm1.2Sve for ARAP3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARAP3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARAP3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARAP3

    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate ARAP3:
    hsa-miR-3671 hsa-miR-218-1* hsa-miR-938 hsa-miR-548aa hsa-miR-935 hsa-miR-659 hsa-miR-193a-5p hsa-miR-299-3p
    SwitchGear 3'UTR luciferase reporter plasmidARAP3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARAP3

    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARAP3
    Addgene plasmids for ARAP3 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARAP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARAP3_HUMAN, Q8WWN8: Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Cell membrane;
    Peripheral membrane protein (By similarity). Cell projection, lamellipodium (By similarity). Cell projection,
    ruffle (By similarity). Note=Cytoplasmic, and associated with F-actin-rich membrane ruffles and lamellipodia (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    cytoskeleton2
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle ISS--
    GO:0005622intracellular ----
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IEA--

    Find genes that share ontologies with ARAP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARAP3 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.58
    3Ras signaling pathway
    Rap1 signaling pathway0.36
    4Regulation of RhoA activity
    Regulation of RhoA activity
    5Endocytosis
    Endocytosis


    Find genes that share SuperPaths with ARAP3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for ARAP3
        Class I PI3K signaling events
    Regulation of RhoA activity

    1 Reactome Pathway for ARAP3
        Rho GTPase cycle


    2 Kegg Pathways  (Kegg details for ARAP3):
        Rap1 signaling pathway
    Endocytosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARAP3
    Interactions:

        Search GeneGlobe Interaction Network for ARAP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARAP3 (Q8WWN81, 2, 3 ENSP000002394404) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3KBP1Q96B971, 2, 3, ENSP000003809214EBI-4402732,EBI-346595 MINT-8109745 MINT-8109758 I2D: score=1 STRING: ENSP00000380921
    ARF6ENSP000002983164STRING: ENSP00000298316
    ARHGAP4ENSP000002037864STRING: ENSP00000203786
    ARHGDIAENSP000002693214STRING: ENSP00000269321
    RAC2ENSP000002490714STRING: ENSP00000249071
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007010cytoskeleton organization TAS15569923
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0008360regulation of cell shape ISS--
    GO:0016192vesicle-mediated transport TAS15569923

    Find genes that share ontologies with ARAP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARAP3

    1 Novoseek inferred chemical compound relationship for ARAP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphoinositide 74.7 20 16139503 (3), 15155809 (2), 12769675 (1), 9891784 (1) (see all 9)



    Find genes that share compounds with ARAP3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARAP3 gene: 
    NM_022481.5  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508305 ENST00000239440(uc011dbe.2 uc003llm.3 uc003lln.3)
    ENST00000512390(uc003lll.3) ENST00000513878 ENST00000504448(uc003llo.1)
    ENST00000524066
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate ARAP3:
    hsa-miR-3671 hsa-miR-218-1* hsa-miR-938 hsa-miR-548aa hsa-miR-935 hsa-miR-659 hsa-miR-193a-5p hsa-miR-299-3p
    SwitchGear 3'UTR luciferase reporter plasmidARAP3 3' UTR sequence
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    Addgene plasmids for ARAP3 
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      QuantiTect SYBR Green Assays in human, mouse, rat ARAP3
      QuantiFast Probe-based Assays in human, mouse, rat ARAP3

    Selected AceView cDNA sequences (see all 120):

    AI656932 AI393655 AI986480 AA705932 BM704884 AI377637 BM982312 BU528556 
    AI755108 BQ189682 AA301591 BC009968 BQ045113 AJ310567 AA344045 BC025757 
    AI358006 AI571572 NM_022481 AI670116 CB241805 AW963098 AU130577 BU931741 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARAP3 (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b · 19c ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                            -               
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33 ^ 34
    SP1:                                                              -                                   -                                 
    SP2:                                                                                                                                    
    SP3:                                                                                                                                    
    SP4:                          -     -                             -                                                                     
    SP5:                                -                             -                                                                     


    ECgene alternative splicing isoforms for ARAP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ARAP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGATTTTG
    ARAP3 Expression
    About this image


    ARAP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 7 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Dermis (Integumentary System)
             Dermal Fibroblasts Dorsal Dermis
     
     Fibroblasts
             Dermal Fibroblasts Dorsal Dermis
     
     Bone (Muscoskeletal System)
             Paraxial Mesoderm Cells Branchial Arch 1
    ARAP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARAP3 Protein Expression
        Custom PCR Arrays for ARAP3
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARAP3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arap31 , 5 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain more1, 5 86.81(n)1
    88.76(a)1
      18 (19.85 cM)5
    1069521  NM_139206.21  NP_631945.21 
     379726245 
    chicken
    (Gallus gallus)
    Aves ARAP31 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain more 65.95(n)
    61.66(a)
      416196  XM_004944759.1  XP_004944816.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARAP36
    ArfGAP with RhoGAP domain, ankyrin repeat and PH d...
    51(a)
    1 ↔ 1
    4(76168332-76223707)
    African clawed frog
    (Xenopus laevis)
    Amphibia BI477541.12   -- 79.15(n)    BI477541.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arap31 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain more 58.15(n)
    54.41(a)
      558931  XM_005173181.1  XP_005173238.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGAP15B3 small GTPase regulatory/interacting
    protein
    28(a)   15C4   --
    worm
    (Caenorhabditis elegans)
    Secernentea F23H11.46
    Protein F23H11.4, isoform a
    20(a)
    1 → many
    III(902212-907539) WBGene00017760
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AGE16
    ADP-ribosylation factor (ARF) GTPase activating pr...
    20(a)
    1 → many
    IV(1487542-1488990) YDR524C


    ENSEMBL Gene Tree for ARAP3 (if available)
    TreeFam Gene Tree for ARAP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARAP3 gene
    AGAP52  AGAP62  ASAP12  ACAP22  ACAP32  ASAP22  ARAP12  AGAP32  
    ARAP22  AGAP22  AGAP42  AGAP12  AGAP82  ACAP12  AGAP72  AGAP102  
    AGAP92  ASAP32  
    6 SIMAP similar genes for ARAP3 using alignment to 6 protein entries:     ARAP3_HUMAN (see all proteins):
    ARFGAP3    ARHGAP9    ARAP2    ARFGAP1    FLJ00357    ARAP1

    Find genes that share paralogs with ARAP3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARAP3 (see all 831)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361824
    A breast cancer sample4--see VAR_0361822 T P mis40--------
    VAR_0361804
    A colorectal cancer sample4--see VAR_0361802 R W mis40--------
    VAR_0361814
    A breast cancer sample4--see VAR_0361812 I M mis40--------
    rs1457520531,2
    Cuntested1141041817(+) CAGCCG/AGAGCC 2 /R /W mis11Minor allele frequency- A:0.00NA 4486
    rs737949611,2
    C,F--141033198(+) CCTACG/ATATCA 1 -- ut312Minor allele frequency- A:0.08WA 120
    rs1842247561,2
    --141033246(+) TATGTG/TGGGCT 1 -- ut310--------
    rs1462510611,2
    C--141033307(+) TACCTA/CATGGT 1 -- ut310--------
    rs1484610161,2
    C--141033324(+) AAATGC/GGCTGG 1 -- ut310--------
    rs2013706201,2
    --141033476(+) TTCTGA/GGTCTT 1 -- ut310--------
    rs100794861,2
    C,H--141033498(+) CCTCTC/GAGACT 1 -- ut31 ese35Minor allele frequency- G:0.00NS EA WA 500

    HapMap Linkage Disequilibrium report for ARAP3 (141032968 - 141061800 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ARAP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730848CNV Deletion23290073
    nsv5034CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARAP3
    DNA2.0 Custom Variant and Variant Library Synthesis for ARAP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606647    OMIM disorders: --


    Find genes that share disorders with ARAP3           About GenesLikeMe

    Genetic Association Database (GAD): ARAP3

    Export disorders for ARAP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARAP3 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with ARAP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. (PubMed id 11804589)1, 2, 3, 9 Krugmann S....Hawkins P.T. (Mol. Cell 2002)
    2. GTPase signaling: bridging the GAP between ARF and Rho. (PubMed id 12015138)1, 2, 3 Santy L.C. and Casanova J.E. (Curr. Biol. 2002)
    3. EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin. (PubMed id 15569923)1, 2, 9 Lu Q.... Cohen S.N. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    4. The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner. (PubMed id 17314030)1, 2 Raaijmakers J.H.... Bos J.L. (Cell. Signal. 2007)
    5. Phosphoinositide 3-OH kinase regulates integrin-dependent processes in neutrophils by signaling through its effector ARAP3. (PubMed id 23180820)1 Gambardella L....Vermeren S. (J. Immunol. 2013)
    6. Heterotypic Sam-Sam association between Odin-Sam1 and Arap3-Sam: binding affinity and structural insights. (PubMed id 23239578)1 Mercurio F.A....Leone M. (Chembiochem 2013)
    7. Identification and structural basis for a novel interaction between Vav2 and Arap3. (PubMed id 22750419)1 Wu B....Shi Y. (J. Struct. Biol. 2012)
    8. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    9. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64411 HGNC: 24097 AceView: ARAP3 Ensembl:ENSG00000120318 euGenes: HUgn64411
    ECgene: ARAP3 Kegg: 64411 H-InvDB: ARAP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARAP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARAP3 gene:
    Search GeneIP for patents involving ARAP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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