Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARAP3 Gene

Aliases for ARAP3 Gene

  • ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 3 2 3
  • Centaurin, Delta 3 2 3
  • Centaurin-Delta-3 3 4
  • Cnt-D3 3 4
  • CENTD3 3 4
  • ARF-GAP, RHO-GAP, Ankyrin Repeat And Plekstrin Homology Domains-Containing Protein 3 3
  • Arf-GAP With Rho-GAP Domain, ANK Repeat And PH Domain-Containing Protein 3 3
  • Arf And Rho GAP Adapter Protein 3 3
  • Phosphoinositide Binding Protein 3
  • PtdIns(3,4,5)P3-Binding Protein 3
  • CENTD3, 6
  • DRAG1 3

External Ids for ARAP3 Gene

Previous HGNC Symbols for ARAP3 Gene

  • CENTD3

Previous GeneCards Identifiers for ARAP3 Gene

  • GC05M140849
  • GC05M141615
  • GC05M141016
  • GC05M141061
  • GC05M141013
  • GC05M136177
  • GC05M141032

Summaries for ARAP3 Gene

Entrez Gene Summary for ARAP3 Gene

  • This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Sep 2008]

GeneCards Summary for ARAP3 Gene

ARAP3 (ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 3) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Signaling by GPCR. GO annotations related to this gene include phosphatidylinositol-3,4,5-trisphosphate binding. An important paralog of this gene is ASAP3.

UniProtKB/Swiss-Prot for ARAP3 Gene

  • Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.

Gene Wiki entry for ARAP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARAP3 Gene

Genomics for ARAP3 Gene

Regulatory Elements for ARAP3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARAP3 Gene

Start:
141,653,401 bp from pter
End:
141,682,233 bp from pter
Size:
28,833 bases
Orientation:
Minus strand

Genomic View for ARAP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARAP3 Gene

Proteins for ARAP3 Gene

  • Protein details for ARAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWN8-ARAP3_HUMAN
    Recommended name:
    Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
    Protein Accession:
    Q8WWN8
    Secondary Accessions:
    • B4DIT1
    • D3DQE3

    Protein attributes for ARAP3 Gene

    Size:
    1544 amino acids
    Molecular mass:
    169844 Da
    Quaternary structure:
    • Interacts (via SAM domain) with INPPL1/SHIP2.

    Three dimensional structures from OCA and Proteopedia for ARAP3 Gene

    Alternative splice isoforms for ARAP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARAP3 Gene

Proteomics data for ARAP3 Gene at MOPED

Post-translational modifications for ARAP3 Gene

  • Tyrosine phosphorylated at a low basal level. PDGF treatment stimulates phosphorylation. Tyrosine phosphorylation is increased in cells that are in the process of becoming attached to a substrate and that start spreading and flattening (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARAP3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ARAP3 Gene

Domains for ARAP3 Gene

Gene Families for ARAP3 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
  • ArfGAP :ADP-ribosylation factor GTPase activating proteins
  • PLEKH :Pleckstrin homology (PH) domain containing
  • SAMD :Sterile alpha motif (SAM) domain containing

Graphical View of Domain Structure for InterPro Entry

Q8WWN8

UniProtKB/Swiss-Prot:

ARAP3_HUMAN :
  • Q8WWN8
Domain:
  • Contains 1 Arf-GAP domain.
  • Contains 3 PH domains.
  • Contains 1 Ras-associating domain.
  • Contains 1 Rho-GAP domain.
  • Contains 1 SAM (sterile alpha motif) domain.
genes like me logo Genes that share domains with ARAP3: view

Function for ARAP3 Gene

Molecular function for ARAP3 Gene

UniProtKB/Swiss-Prot Function: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.

Gene Ontology (GO) - Molecular Function for ARAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 NOT GTPase activator activity ISS --
GO:0005515 protein binding IPI 15090612
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA 11804589
GO:0008270 zinc ion binding IEA --
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding IDA 11804589
genes like me logo Genes that share ontologies with ARAP3: view
genes like me logo Genes that share phenotypes with ARAP3: view

Animal Models for ARAP3 Gene

MGI Knock Outs for ARAP3:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ARAP3 Gene

Localization for ARAP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARAP3 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Cell projection, lamellipodium. Cell projection, ruffle. Note=Cytoplasmic, and associated with F-actin-rich membrane ruffles and lamellipodia. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARAP3 Gene COMPARTMENTS Subcellular localization image for ARAP3 gene
Compartment Confidence
plasma membrane 5
cytosol 4
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for ARAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle ISS --
GO:0005622 intracellular --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ARAP3: view

Pathways for ARAP3 Gene

genes like me logo Genes that share pathways with ARAP3: view

Pathways by source for ARAP3 Gene

2 BioSystems pathways for ARAP3 Gene
2 KEGG pathways for ARAP3 Gene

Gene Ontology (GO) - Biological Process for ARAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization TAS 15569923
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0008360 regulation of cell shape ISS --
GO:0016192 vesicle-mediated transport TAS 15569923
genes like me logo Genes that share ontologies with ARAP3: view

Compounds for ARAP3 Gene

(1) Novoseek inferred chemical compound relationships for ARAP3 Gene

Compound -log(P) Hits PubMed IDs
phosphoinositide 74.7 12
genes like me logo Genes that share compounds with ARAP3: view

Transcripts for ARAP3 Gene

Unigene Clusters for ARAP3 Gene

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARAP3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ARAP3
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARAP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b · 19c ^
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33 ^ 34
SP1: - -
SP2:
SP3:
SP4: - - -
SP5: - -
SP6:
SP7: -
SP8: -
SP9: - -
SP10:
SP11:
SP12:
SP13:

Relevant External Links for ARAP3 Gene

GeneLoc Exon Structure for
ARAP3
ECgene alternative splicing isoforms for
ARAP3

Expression for ARAP3 Gene

mRNA expression in normal human tissues for ARAP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARAP3 Gene

This gene is overexpressed in Whole Blood (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARAP3 Gene

SOURCE GeneReport for Unigene cluster for ARAP3 Gene Hs.726187

genes like me logo Genes that share expressions with ARAP3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ARAP3 Gene

Orthologs for ARAP3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARAP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARAP3 35
  • 99.43 (n)
  • 99.54 (a)
ARAP3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARAP3 35
  • 89.51 (n)
  • 91.05 (a)
ARAP3 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARAP3 35
  • 90.18 (n)
  • 92.02 (a)
ARAP3 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arap3 35
  • 86.81 (n)
  • 88.76 (a)
Arap3 16
Arap3 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARAP3 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARAP3 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arap3 35
  • 85.92 (n)
  • 88.54 (a)
chicken
(Gallus gallus)
Aves ARAP3 35
  • 65.95 (n)
  • 61.66 (a)
ARAP3 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARAP3 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arap3 35
  • 59.65 (n)
  • 56.83 (a)
Str.16223 35
zebrafish
(Danio rerio)
Actinopterygii arap3 35
  • 58.15 (n)
  • 54.41 (a)
arap3 36
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP15B 36
  • 16 (a)
OneToMany
RhoGAP15B 37
  • 28 (a)
worm
(Caenorhabditis elegans)
Secernentea F23H11.4 36
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AGE1 36
  • 20 (a)
OneToMany
Species with no ortholog for ARAP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARAP3 Gene

ENSEMBL:
Gene Tree for ARAP3 (if available)
TreeFam:
Gene Tree for ARAP3 (if available)

Paralogs for ARAP3 Gene

Selected SIMAP similar genes for ARAP3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ARAP3: view

Variants for ARAP3 Gene

Sequence variations from dbSNP and Humsavar for ARAP3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs364305 -- 141,679,152(+) ggcat(A/G)gtggc intron-variant
rs417503 -- 141,680,082(+) GGAGG(A/G)GGCCT synonymous-codon, reference, intron-variant
rs440279 -- 141,673,303(+) GCCCC(C/G)CCCAC intron-variant
rs445123 -- 141,674,518(+) CTCCC(A/G)AATTG intron-variant
rs622766 -- 141,675,021(+) AAGAA(C/T)TTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARAP3 Gene

Variant ID Type Subtype PubMed ID
nsv5034 CNV Insertion 18451855
esv2730848 CNV Deletion 23290073

Relevant External Links for ARAP3 Gene

HapMap Linkage Disequilibrium report
ARAP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARAP3 Gene

Disorders for ARAP3 Gene

Relevant External Links for ARAP3

Genetic Association Database (GAD)
ARAP3
genes like me logo Genes that share disorders with ARAP3: view

No data available for UniProtKB/Swiss-Prot for ARAP3 Gene

Publications for ARAP3 Gene

  1. Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. (PMID: 11804589) Krugmann S. … Hawkins P.T. (Mol. Cell 2002) 2 3 4 23
  2. GTPase signaling: bridging the GAP between ARF and Rho. (PMID: 12015138) Santy L.C. … Casanova J.E. (Curr. Biol. 2002) 2 3 4
  3. EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin. (PMID: 15569923) Lu Q. … Cohen S.N. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 23
  4. The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner. (PMID: 17314030) Raaijmakers J.H. … Bos J.L. (Cell. Signal. 2007) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for ARAP3 Gene

  • Addgene plasmids for ARAP3

Sources for ARAP3 Gene

Back to Top

Content