Aliases for ARAP2 Gene
External Ids for ARAP2 Gene
Previous HGNC Symbols for ARAP2 Gene
Previous GeneCards Identifiers for ARAP2 Gene
The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]
GeneCards Summary for ARAP2 Gene
ARAP2 (ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 2) is a Protein Coding gene. Diseases associated with ARAP2 include loiasis and urinary schistosomiasis. Among its related pathways are Ras signaling pathway and Signaling by GPCR. GO annotations related to this gene include phosphatidylinositol-3,4,5-trisphosphate binding. An important paralog of this gene is ASAP3.
UniProtKB/Swiss-Prot for ARAP2 Gene
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity).