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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARAP2 Gene

protein-coding   GIFtS: 55
GCID: GC04M035950

ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain...

(Previous names: centaurin, delta 1)
(Previous symbol: CENTD1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 21 2     Arf-GAP With Rho-GAP Domain, ANK Repeat And PH Domain-Containing Protein 22
CENTD11 2 3 5     centaurin-delta-12
Centaurin, Delta 11 2     cnt-d12
KIAA05803 5     Centaurin-delta-13
PARX2     Cnt-d13
Arf And Rho GAP Adapter Protein 22     Protein PARX3

External Ids:    HGNC: 169241   Entrez Gene: 1169842   Ensembl: ENSG000000473657   OMIM: 6066455   UniProtKB: Q8WZ643   

Export aliases for ARAP2 gene to outside databases

Previous GC identifers: GC04M035744 GC04M036067 GC04M035394


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARAP2 Gene:
The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin
homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds
RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity.
The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics.
(provided by RefSeq, Sep 2008)

GeneCards Summary for ARAP2 Gene: 
ARAP2 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2) is a protein-coding gene. Diseases associated with ARAP2 include loiasis, and urinary schistosomiasis, and among its related super-pathways are Signaling by Rho GTPases and Signaling by GPCR. GO annotations related to this gene include ARF GTPase activator activity and phosphatidylinositol-3,4,5-trisphosphate binding. An important paralog of this gene is AGAP5.

UniProtKB/Swiss-Prot: ARAP2_HUMAN, Q8WZ64
Function: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin
cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol
3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate
(PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity)

Gene Wiki entry for ARAP2 (CENTD1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016297.16  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARAP2 gene promoter:
         AML1a   MEF-2   RORalpha2   Evi-1   MEF-2A   POU2F1   POU2F1a   aMEF-2   RSRFC4   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARAP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARAP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p14   Ensembl cytogenetic band:  4p14   HGNC cytogenetic band: 4p15.1

ARAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARAP2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M035950:  view genomic region     (about GC identifiers)

Start:
35,949,843 bp from pter      End:
36,246,131 bp from pter
Size:
296,289 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARAP2_HUMAN, Q8WZ64 (See protein sequence)
Recommended Name: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2  
Size: 1704 amino acids; 193452 Da
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AAL04166.1; Type=Frameshift; Positions=1579;
2 PDB 3D structures from and Proteopedia for ARAP2:
1X40 (3D)        2COD (3D)    
Secondary accessions: Q4W5D2 Q7Z2L5 Q96L70 Q96P49 Q9Y4E4

Explore the universe of human proteins at neXtProt for ARAP2: NX_Q8WZ64

Explore proteomics data for ARAP2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WZ64

  • ARAP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARAP2 Protein Expression
    REFSEQ proteins: NP_056045.2  
    ENSEMBL proteins: 
     ENSP00000302895   ENSP00000423886   ENSP00000422731  
    Reactome Protein details: Q8WZ64
    Human Recombinant Protein Products for ARAP2: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--

    ARAP2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing
    ANKRD: Ankyrin repeat domain containing
    ArfGAP: ADP-ribosylation factor GTPase activating proteins
    SAMD: Sterile alpha motif (SAM) domain containing

    5/9 InterPro protein domains (see all 9):
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR021129 SAM_type1
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology

    Graphical View of Domain Structure for InterPro Entry Q8WZ64

    ProtoNet protein and cluster: Q8WZ64

    5 Blocks protein domains:
    IPB000159 RA domain
    IPB000198 RhoGAP domain
    IPB001164 HIV Rev interacting protein signature
    IPB001660 Sterile alpha motif SAM
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: ARAP2_HUMAN, Q8WZ64
    Similarity: Contains 1 Arf-GAP domain
    Similarity: Contains 5 PH domains
    Similarity: Contains 1 Ras-associating domain
    Similarity: Contains 1 Rho-GAP domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    ARAP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARAP2_HUMAN, Q8WZ64
    Function: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin
    cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol
    3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate
    (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005543phospholipid binding ----
    GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding IDA11804589
    GO:0008060ARF GTPase activator activity IEA--
    GO:0008270zinc ion binding IEA--
         
    ARAP2 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidARAP2 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARAP2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.55
    3Endocytosis
    Endocytosis
    4Arf6 signaling events
    Arf6 signaling events

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ARAP2
        Arf6 signaling events

    3        Reactome Pathways for ARAP2
        Signaling by Rho GTPases
    Signal Transduction
    Rho GTPase cycle


    1         Kegg Pathway  (Kegg details for ARAP2):
        Endocytosis


    ARAP2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARAP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/36 Interacting proteins for ARAP2 (Q8WZ642 ENSP000003028954) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARF6ENSP000002983164STRING: ENSP00000298316
    GDI2ENSP000003695384STRING: ENSP00000369538
    ARHGAP4ENSP000002037864STRING: ENSP00000203786
    ARHGDIAENSP000002693214STRING: ENSP00000269321
    ARHGDIBENSP000002289454STRING: ENSP00000228945
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0032312regulation of ARF GTPase activity IEA--
    GO:0051056regulation of small GTPase mediated signal transduction TAS--

    ARAP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARAP2

    Search CenterWatch for drugs/clinical trials and news about ARAP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARAP2 gene (2 alternative transcripts): 
    NM_015230.3  NM_139182.1  

    Unigene Cluster for ARAP2:

    ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
    Hs.479451  [show with all ESTs]
    Unigene Representative Sequence: NM_015230
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000503225(uc003gso.3) ENST00000513032 ENST00000505837 ENST00000303965(uc003gsq.2)
    ENST00000512804 ENST00000503904 ENST00000508066(uc003gsr.1) ENST00000511416
    ENST00000506189
    miRNA
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    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate ARAP2 (see all 58):
    hsa-miR-142-5p hsa-miR-579 hsa-miR-4328 hsa-miR-300 hsa-miR-106a hsa-miR-938 hsa-miR-30d hsa-miR-624
    SwitchGear 3'UTR luciferase reporter plasmidARAP2 3' UTR sequence
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    Additional mRNA sequence: 

    AB011152.2 AF411982.1 AF439781.1 AK126864.1 AY049733.1 BC031283.1 BC105089.1 BC105091.1 
    BC150258.1 

    9 DOTS entries:

    DT.312377  DT.101975654  DT.99932656  DT.100019194  DT.91703831  DT.99971847  DT.121256429  DT.121256406 
    DT.95155198 

    24/127 AceView cDNA sequences (see all 127):

    AA743378 AU140056 BE464109 AW271348 BM127801 CB250545 AA743233 NM_015230 
    AF411982 AW183858 BX488924 CB157753 BF592992 NM_139182 AI470829 AF439781 
    AB011152 BM054835 AI880228 AY049733 AK126864 CK904685 CF457254 CF457162 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ARAP2    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
    SP1:                                                                                                                    -                                       
    SP2:                    -                                                                                                                                       
    SP3:                                                                                                                                                            
    SP4:        -     -     -                                                                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33
    SP1:                                                                                    
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for ARAP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARAP2 expression in normal human tissues (normalized intensities)      ARAP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ARAP2 Expression
    About this image


    ARAP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Liver (Hepatobiliary System)
             Mature Mesothelial Cells Hepatic Mesenchyme
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells II Spleen
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells II Spleen
     
     Stomach (Gastrointestinal Tract)

    See ARAP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARAP2

    SOURCE GeneReport for Unigene cluster: Hs.479451

    UniProtKB/Swiss-Prot: ARAP2_HUMAN, Q8WZ64
    Tissue specificity: Detected in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle,
    spleen, kidney, liver, placenta, lung and peripheral blood leukocytes

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARAP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARAP2 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arap21 , 5 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain more1, 5 84.24(n)1
    83.49(a)1
      5 (32.04 cM)5
    2122851  NM_178407.31  NP_848494.21 
     626024455 
    chicken
    (Gallus gallus)
    Aves ARAP21 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain more 68.27(n)
    63.96(a)
      428790  XM_426346.3  XP_426346.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    69(a)
    35(a)
    1 ↔ many
    1 ↔ many
    GL343823.1(80165-159045)
    GL343598.1(25459-83884)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5596901 arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing more 53.7(n)
    45.43(a)
      559690  XM_683053.5  XP_688145.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGAP15B6
    RhoGAP15B
    15(a)
    possible ortholog
    X(16837752-16850028)
    worm
    (Caenorhabditis elegans)
    Secernentea git-16
    F23H11.46
    Protein F23H11.4, isoform a
    13(a)
    13(a)
    1 ↔ 1
    possible ortholog
    X(10524898-10528437)
    III(902212-907541)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AGE16
    ADP-ribosylation factor (ARF) GTPase activating pr...
    18(a)
    1 → many
    IV(1487542-1488990)


    ENSEMBL Gene Tree for ARAP2 (if available)
    TreeFam Gene Tree for ARAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARAP2 gene
    AGAP52  AGAP62  ASAP12  ARAP32  ACAP22  ACAP32  ASAP22  ARAP12  
    AGAP32  AGAP22  AGAP42  AGAP12  AGAP82  ACAP12  AGAP72  AGAP102  
    AGAP92  ASAP32  
    3 SIMAP similar genes for ARAP2 using alignment to 5 protein entries:     ARAP2_HUMAN (see all proteins):
    ARAP1    ARAP3    ARFGAP1

    ARAP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3593 SNPs in ARAP2 are shown (see all 3593)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs731234501,2
    C,F--36067141(+) GCAGGG/ACAGGC 1 -- int12Minor allele frequency- A:0.07WA 120
    rs783585641,2
    F--36067173(+) CATGGG/CCCTCA 1 -- int11Minor allele frequency- C:0.03NA 120
    rs1128793531,2
    C,F--36067244(+) CTGAAC/TATGAG 1 -- int12Minor allele frequency- T:0.10CSA WA 120
    rs1896551401,2
    --36067502(+) AAAACA/GATACA 1 -- int10--------
    rs1163859331,2
    C,F--36067509(+) TACAGC/ACAGTT 1 -- int11Minor allele frequency- A:0.03NA 120
    rs1434120501,2
    --36067573(+) TTGATC/TTATTT 1 -- int10--------
    rs738064341,2
    C--36067607(+) GAAAAT/CAATAA 1 -- int12Minor allele frequency- C:0.05WA 120
    rs1483455671,2
    --36067800(+) TCTAGA/GTACTT 1 -- ut310--------
    rs1822714491,2
    --36068081(+) GATCCA/GTATTT 1 -- ut310--------
    rs22718101,2
    C,F,A,H--36068286(+) CTAACA/GTGAAC 1 -- ut31 ese328Minor allele frequency- G:0.33EA NS NA WA CSA 4201

    HapMap Linkage Disequilibrium report for ARAP2 (35949843 - 36199843 bp, first 250kb of ARAP2)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ARAP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv461332CNV Loss19166990
    nsv4300CNV Loss18451855
    nsv509889CNV Loss20534489
    nsv829906CNV Gain17160897
    nsv829905CNV Gain17160897
    nsv829907CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606645    OMIM disorders: --

    7 diseases for ARAP2:    About MalaCards
    loiasis    urinary schistosomiasis    strongyloidiasis    schistosomiasis
    rheumatoid arthritis    arthritis    thyroiditis

    2 diseases from the University of Copenhagen DISEASES database for ARAP2:
    Loiasis     Urinary schistosomiasis

    ARAP2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARAP2

    Export disorders for ARAP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARAP2 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with ARAP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    2. ARAP1: a point of convergence for Arf and Rho signaling. (PubMed id 11804590)1, 2 Miura K.... Randazzo P.A. (2002)
    3. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (1998)
    4. Age of onset of amyotrophic lateral sclerosis is modul ated by a locus on 1p34.1. (PubMed id 22959728)1  ....Zheng J.G. (2013)
    5. ARAP2 signals through Arf6 and Rac1 to control focal a dhesion morphology. (PubMed id 23295182)1 Chen P.W....Randazzo P.A. (2013)
    6. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    7. A genome-wide association study identifies a novel ma jor locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PubMed id 19875614)4 Paterson A.D....Bull S.B. (2010)
    8. Critical role for the host GTPase-activating protein ARAP2 in InlB-mediated entry of Listeria monocytogenes. (PubMed id 20823205)1 Gavicherla B....Ireton K. (2010)
    9. The SH3 domain of postsynaptic density 95 mediates inf lammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (2010)
    10. Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in Rheumatoid Arthritis. (PubMed id 18615156)1 Liu C....Gregersen P.K. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 116984 HGNC: 16924 AceView: CENTD1 Ensembl:ENSG00000047365 euGenes: HUgn116984
    ECgene: ARAP2 Kegg: 116984 H-InvDB: ARAP2

    (According to HUGE)
    About This Section
    HUGE: KIAA0580

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARAP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARAP2 gene:
    Search GeneIP for patents involving ARAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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