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ARAP2 Gene

protein-coding   GIFtS: 54
GCID: GC04M035950

ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain...

(Previous names: centaurin, delta 1)
(Previous symbol: CENTD1)
  See ARAP2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 21 2     Arf-GAP With Rho-GAP Domain, ANK Repeat And PH Domain-Containing Protein 22
CENTD11 2 3 5     centaurin-delta-12
Centaurin, Delta 11 2     cnt-d12
KIAA05803 5     Centaurin-delta-13
PARX2     Cnt-d13
Arf And Rho GAP Adapter Protein 22     Protein PARX3

External Ids:    HGNC: 169241   Entrez Gene: 1169842   Ensembl: ENSG000000473657   OMIM: 6066455   UniProtKB: Q8WZ643   

Export aliases for ARAP2 gene to outside databases

Previous GC identifers: GC04M035744 GC04M036067 GC04M035394


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARAP2 Gene:
The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin
homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds
RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity.
The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics.
(provided by RefSeq, Sep 2008)

GeneCards Summary for ARAP2 Gene:
ARAP2 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2) is a protein-coding gene. Diseases associated with ARAP2 include loiasis, and urinary schistosomiasis. GO annotations related to this gene include ARF GTPase activator activity and phosphatidylinositol-3,4,5-trisphosphate binding. An important paralog of this gene is AGAP5.

UniProtKB/Swiss-Prot: ARAP2_HUMAN, Q8WZ64
Function: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin
cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol
3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate
(PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity)

Gene Wiki entry for ARAP2 (CENTD1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006238.12  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARAP2 gene promoter:
         AML1a   MEF-2   RORalpha2   Evi-1   MEF-2A   POU2F1   POU2F1a   aMEF-2   RSRFC4   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARAP2 promoter sequence
   Search Chromatin IP Primers for ARAP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p14   Ensembl cytogenetic band:  4p14   HGNC cytogenetic band: 4p15.1

ARAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARAP2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M035950:  view genomic region     (about GC identifiers)

Start:
35,949,843 bp from pter      End:
36,246,131 bp from pter
Size:
296,289 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ARAP2_HUMAN, Q8WZ64 (See protein sequence)
Recommended Name: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2  
Size: 1704 amino acids; 193452 Da
Sequence caution: Sequence=AAL04166.1; Type=Frameshift; Positions=1579;
2 PDB 3D structures from and Proteopedia for ARAP2:
1X40 (3D)        2COD (3D)    
Secondary accessions: Q4W5D2 Q7Z2L5 Q96L70 Q96P49 Q9Y4E4

Explore the universe of human proteins at neXtProt for ARAP2: NX_Q8WZ64

Explore proteomics data for ARAP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARAP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056045.2  
    ENSEMBL proteins: 
     ENSP00000302895   ENSP00000423886   ENSP00000422731  
    Reactome Protein details: Q8WZ64

    ARAP2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    ANKRD: Ankyrin repeat domain containing
    ArfGAP: ADP-ribosylation factor GTPase activating proteins
    SAMD: Sterile alpha motif (SAM) domain containing

    Selected InterPro protein domains (see all 9):
     IPR021129 SAM_type1
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR001164 ArfGAP
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q8WZ64

    ProtoNet protein and cluster: Q8WZ64

    5 Blocks protein domains:
    IPB000159 RA domain
    IPB000198 RhoGAP domain
    IPB001164 HIV Rev interacting protein signature
    IPB001660 Sterile alpha motif SAM
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: ARAP2_HUMAN, Q8WZ64
    Similarity: Contains 1 Arf-GAP domain
    Similarity: Contains 5 PH domains
    Similarity: Contains 1 Ras-associating domain
    Similarity: Contains 1 Rho-GAP domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Find genes that share domains with ARAP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARAP2_HUMAN, Q8WZ64
    Function: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin
    cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol
    3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate
    (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding IDA11804589
    GO:0008060ARF GTPase activator activity IEA--
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with ARAP2           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Arap2):
     no phenotypic analysis 

    Find genes that share phenotypes with ARAP2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ARAP2

    miRNA
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    miRTarBase miRNAs that target ARAP2:
    hsa-mir-101-3p (MIRT027376), hsa-mir-26b-5p (MIRT030346)

    Block miRNA regulation of human, mouse, rat ARAP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARAP2 (see all 58):
    hsa-miR-142-5p hsa-miR-579 hsa-miR-4328 hsa-miR-300 hsa-miR-106a hsa-miR-938 hsa-miR-30d hsa-miR-624
    SwitchGear 3'UTR luciferase reporter plasmidARAP2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARAP2_HUMAN, Q8WZ64: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with ARAP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARAP2 About    
    See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.58
    3Ras signaling pathway
    Rap1 signaling pathway0.36
    4Endocytosis
    Endocytosis
    5Arf6 signaling events
    Arf6 signaling events


    Find genes that share SuperPaths with ARAP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ARAP2
        Arf6 signaling events

    1 Reactome Pathway for ARAP2
        Rho GTPase cycle


    2 Kegg Pathways  (Kegg details for ARAP2):
        Rap1 signaling pathway
    Endocytosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARAP2
    Interactions:

        Search GeneGlobe Interaction Network for ARAP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARAP2 (Q8WZ642 ENSP000003028954) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARF6ENSP000002983164STRING: ENSP00000298316
    ARHGAP4ENSP000002037864STRING: ENSP00000203786
    GDI2ENSP000003695384STRING: ENSP00000369538
    RHOGENSP000003394674STRING: ENSP00000339467
    ARHGDIAENSP000002693214STRING: ENSP00000269321
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0032312regulation of ARF GTPase activity IEA--
    GO:0051056regulation of small GTPase mediated signal transduction TAS--

    Find genes that share ontologies with ARAP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for ARAP2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARAP2 gene (2 alternative transcripts): 
    NM_015230.3  NM_139182.1  

    Unigene Cluster for ARAP2:

    ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
    Hs.479451  [show with all ESTs]
    Unigene Representative Sequence: NM_015230
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000503225(uc003gso.3) ENST00000513032 ENST00000505837 ENST00000303965(uc003gsq.2)
    ENST00000512804 ENST00000503904 ENST00000508066(uc003gsr.1) ENST00000511416
    ENST00000506189
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ARAP2 (see all 58):
    hsa-miR-142-5p hsa-miR-579 hsa-miR-4328 hsa-miR-300 hsa-miR-106a hsa-miR-938 hsa-miR-30d hsa-miR-624
    SwitchGear 3'UTR luciferase reporter plasmidARAP2 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat ARAP2

    Additional mRNA sequence: 

    AB011152.2 AF411982.1 AF439781.1 AK126864.1 AY049733.1 BC031283.1 BC105089.1 BC105091.1 
    BC150258.1 

    9 DOTS entries:

    DT.312377  DT.101975654  DT.99932656  DT.100019194  DT.91703831  DT.99971847  DT.121256429  DT.121256406 
    DT.95155198 

    Selected AceView cDNA sequences (see all 127):

    AF411982 BF592992 AF439781 AU140056 AK126864 NM_139182 AW271348 BX488924 
    CB157753 CB250545 NM_015230 AA743378 CK904685 AY049733 AI880228 AA743233 
    BM127801 AB011152 AI470829 AW183858 BM054835 BE464109 BM469680 BX457503 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ARAP2    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
    SP1:                                                                                                                    -                                       
    SP2:                    -                                                                                                                                       
    SP3:                                                                                                                                                            
    SP4:        -     -     -                                                                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33
    SP1:                                                                                    
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for ARAP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARAP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ARAP2 Expression
    About this image


    ARAP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Hair (Integumentary System)
             Bulge Stem Cells Bulge
     
     Liver (Hepatobiliary System)
             Mature Mesothelial Cells Hepatic Mesenchyme
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells II Spleen
    ARAP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARAP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.479451

    UniProtKB/Swiss-Prot: ARAP2_HUMAN, Q8WZ64
    Tissue specificity: Detected in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle,
    spleen, kidney, liver, placenta, lung and peripheral blood leukocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARAP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARAP2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arap21 , 5 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain more1, 5 84.24(n)1
    83.49(a)1
      5 (32.04 cM)5
    2122851  NM_178407.31  NP_848494.21 
     626024455 
    chicken
    (Gallus gallus)
    Aves ARAP21 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain more 68.67(n)
    64.4(a)
      428790  XM_426346.4  XP_426346.4 
    lizard
    (Anolis carolinensis)
    Reptilia ARAP26
    ArfGAP with RhoGAP domain, ankyrin repeat and PH d...
    69(a)
    1 ↔ 1
    GL343823.1(80165-159045)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia arap21 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain more 61.18(n)
    53.81(a)
      100494395  XM_002938651.2  XP_002938697.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5596901 arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing more 56.2(n)
    50.81(a)
      559690  XM_683053.6  XP_688145.6 
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGAP15B6
    RhoGAP15B
    18(a)
    1 → many
    X(16837752-16850028)
    worm
    (Caenorhabditis elegans)
    Secernentea F23H11.46
    Protein F23H11.4, isoform a
    19(a)
    1 → many
    III(902212-907539) WBGene00017760
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AGE16
    ADP-ribosylation factor (ARF) GTPase activating pr...
    22(a)
    1 → many
    IV(1487542-1488990) YDR524C


    ENSEMBL Gene Tree for ARAP2 (if available)
    TreeFam Gene Tree for ARAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARAP2 gene
    AGAP52  AGAP62  ASAP12  ARAP32  ACAP22  ACAP32  ASAP22  ARAP12  
    AGAP32  AGAP22  AGAP42  AGAP12  AGAP82  ACAP12  AGAP72  AGAP102  
    AGAP92  ASAP32  
    3 SIMAP similar genes for ARAP2 using alignment to 5 protein entries:     ARAP2_HUMAN (see all proteins):
    ARAP1    ARAP3    ARFGAP1

    Find genes that share paralogs with ARAP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARAP2 (see all 3593)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs731234501,2
    C,F--36067141(+) GCAGGG/ACAGGC 1 -- int12Minor allele frequency- A:0.07WA 120
    rs783585641,2
    F--36067173(+) CATGGG/CCCTCA 1 -- int11Minor allele frequency- C:0.03NA 120
    rs1128793531,2
    C,F--36067244(+) CTGAAC/TATGAG 1 -- int12Minor allele frequency- T:0.10CSA WA 120
    rs1896551401,2
    --36067502(+) AAAACA/GATACA 1 -- int10--------
    rs1163859331,2
    C,F--36067509(+) TACAGC/ACAGTT 1 -- int11Minor allele frequency- A:0.03NA 120
    rs1434120501,2
    --36067573(+) TTGATC/TTATTT 1 -- int10--------
    rs738064341,2
    C--36067607(+) GAAAAT/CAATAA 1 -- int12Minor allele frequency- C:0.05WA 120
    rs1483455671,2
    --36067800(+) TCTAGA/GTACTT 1 -- ut310--------
    rs1822714491,2
    --36068081(+) GATCCA/GTATTT 1 -- ut310--------
    rs22718101,2
    C,F,A,H--36068286(+) CTAACA/GTGAAC 1 -- ut31 ese328Minor allele frequency- G:0.33EA NS NA WA CSA 4201

    HapMap Linkage Disequilibrium report for ARAP2 (35949843 - 36199843 bp, first 250kb of ARAP2)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ARAP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv461332CNV Loss19166990
    nsv4300CNV Loss18451855
    nsv509889CNV Loss20534489
    nsv829906CNV Gain17160897
    nsv829905CNV Gain17160897
    nsv829907CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARAP2
    DNA2.0 Custom Variant and Variant Library Synthesis for ARAP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606645    OMIM disorders: --

    2 diseases for ARAP2:    
    About MalaCards
    loiasis    urinary schistosomiasis

    2 diseases from the University of Copenhagen DISEASES database for ARAP2:
    Loiasis     Urinary schistosomiasis

    Find genes that share disorders with ARAP2           About GenesLikeMe

    Genetic Association Database (GAD): ARAP2

    Export disorders for ARAP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARAP2 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with ARAP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    2. ARAP1: a point of convergence for Arf and Rho signaling. (PubMed id 11804590)1, 2 Miura K.... Randazzo P.A. (Mol. Cell 2002)
    3. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (DNA Res. 1998)
    4. Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1. (PubMed id 22959728)1  ....Zheng J.G. (Neurobiol. Aging 2013)
    5. ARAP2 signals through Arf6 and Rac1 to control focal adhesion morphology. (PubMed id 23295182)1 Chen P.W....Randazzo P.A. (J. Biol. Chem. 2013)
    6. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    7. Critical role for the host GTPase-activating protein ARAP2 in InlB-mediated entry of Listeria monocytogenes. (PubMed id 20823205)1 Gavicherla B....Ireton K. (Infect. Immun. 2010)
    8. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
    9. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PubMed id 19875614)4 Paterson A.D....Bull S.B. (Diabetes 2010)
    10. Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis. (PubMed id 18615156)1 Liu C....Gregersen P.K. (Mol. Med. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 116984 HGNC: 16924 AceView: CENTD1 Ensembl:ENSG00000047365 euGenes: HUgn116984
    ECgene: ARAP2 Kegg: 116984 H-InvDB: ARAP2

    (According to HUGE)
    About This Section

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    HUGE: KIAA0580

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ARAP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARAP2 gene:
    Search GeneIP for patents involving ARAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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