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Aliases for ARAP2 Gene

Aliases for ARAP2 Gene

  • ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 2 2 3 5
  • Centaurin, Delta 1 2 3
  • Centaurin-Delta-1 3 4
  • Cnt-D1 3 4
  • CENTD1 3 4
  • Arf And Rho GAP Adapter Protein 2 3
  • Protein PARX 4
  • KIAA0580 4
  • PARX 3

External Ids for ARAP2 Gene

Previous HGNC Symbols for ARAP2 Gene

  • CENTD1

Previous GeneCards Identifiers for ARAP2 Gene

  • GC04M035744
  • GC04M036067
  • GC04M035394

Summaries for ARAP2 Gene

Entrez Gene Summary for ARAP2 Gene

  • The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]

GeneCards Summary for ARAP2 Gene

ARAP2 (ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 2) is a Protein Coding gene. Among its related pathways are Signaling by Rho GTPases and Arf6 signaling events. GO annotations related to this gene include GTPase activator activity and phosphatidylinositol-3,4,5-trisphosphate binding. An important paralog of this gene is ASAP3.

UniProtKB/Swiss-Prot for ARAP2 Gene

  • Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity).

Gene Wiki entry for ARAP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARAP2 Gene

Genomics for ARAP2 Gene

Regulatory Elements for ARAP2 Gene

Enhancers for ARAP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARAP2 on UCSC Golden Path with GeneCards custom track

Promoters for ARAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARAP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARAP2 Gene

Chromosome:
4
Start:
35,948,221 bp from pter
End:
36,244,509 bp from pter
Size:
296,289 bases
Orientation:
Minus strand

Genomic View for ARAP2 Gene

Genes around ARAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARAP2 Gene

Proteins for ARAP2 Gene

  • Protein details for ARAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WZ64-ARAP2_HUMAN
    Recommended name:
    Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
    Protein Accession:
    Q8WZ64
    Secondary Accessions:
    • Q4W5D2
    • Q7Z2L5
    • Q96L70
    • Q96P49
    • Q9Y4E4

    Protein attributes for ARAP2 Gene

    Size:
    1704 amino acids
    Molecular mass:
    193452 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL04166.1; Type=Frameshift; Positions=1579; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARAP2 Gene

neXtProt entry for ARAP2 Gene

Proteomics data for ARAP2 Gene at MOPED

Post-translational modifications for ARAP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARAP2 Gene

No data available for DME Specific Peptides for ARAP2 Gene

Domains & Families for ARAP2 Gene

Suggested Antigen Peptide Sequences for ARAP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WZ64

UniProtKB/Swiss-Prot:

ARAP2_HUMAN :
  • Contains 1 Arf-GAP domain.
Domain:
  • Contains 1 Arf-GAP domain.
  • Contains 5 PH domains.
  • Contains 1 Ras-associating domain.
  • Contains 1 Rho-GAP domain.
  • Contains 1 SAM (sterile alpha motif) domain.
genes like me logo Genes that share domains with ARAP2: view

Function for ARAP2 Gene

Molecular function for ARAP2 Gene

UniProtKB/Swiss-Prot Function:
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity).

Gene Ontology (GO) - Molecular Function for ARAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ARAP2: view
genes like me logo Genes that share phenotypes with ARAP2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARAP2 Gene

Localization for ARAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARAP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARAP2 Gene COMPARTMENTS Subcellular localization image for ARAP2 gene
Compartment Confidence
cytosol 5
nucleus 3
cytoskeleton 2

No data available for Gene Ontology (GO) - Cellular Components for ARAP2 Gene

Pathways & Interactions for ARAP2 Gene

genes like me logo Genes that share pathways with ARAP2: view

Pathways by source for ARAP2 Gene

1 GeneTex pathway for ARAP2 Gene
1 BioSystems pathway for ARAP2 Gene
1 KEGG pathway for ARAP2 Gene

Interacting Proteins for ARAP2 Gene

Gene Ontology (GO) - Biological Process for ARAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARAP2: view

No data available for SIGNOR curated interactions for ARAP2 Gene

Drugs & Compounds for ARAP2 Gene

No Compound Related Data Available

Transcripts for ARAP2 Gene

Unigene Clusters for ARAP2 Gene

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARAP2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
SP1: -
SP2: -
SP3:
SP4: - - -
SP5:

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for ARAP2 Gene

GeneLoc Exon Structure for
ARAP2
ECgene alternative splicing isoforms for
ARAP2

Expression for ARAP2 Gene

mRNA expression in normal human tissues for ARAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARAP2 Gene

This gene is overexpressed in Prostate (41.5), Bone marrow mesenchymal stem cell (17.3), and Cervix (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARAP2 Gene



SOURCE GeneReport for Unigene cluster for ARAP2 Gene Hs.479451

mRNA Expression by UniProt/SwissProt for ARAP2 Gene

Q8WZ64-ARAP2_HUMAN
Tissue specificity: Detected in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with ARAP2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for ARAP2 Gene

Orthologs for ARAP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARAP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARAP2 35
  • 89.16 (n)
  • 85.92 (a)
ARAP2 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARAP2 35
  • 89.52 (n)
  • 88.12 (a)
ARAP2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arap2 35
  • 84.24 (n)
  • 83.49 (a)
Arap2 16
Arap2 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARAP2 35
  • 99.47 (n)
  • 99.06 (a)
ARAP2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arap2 35
  • 84.46 (n)
  • 82.47 (a)
oppossum
(Monodelphis domestica)
Mammalia ARAP2 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARAP2 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARAP2 35
  • 68.67 (n)
  • 64.4 (a)
ARAP2 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARAP2 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arap2 35
  • 61.18 (n)
  • 53.81 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC559690 35
  • 56.2 (n)
  • 50.81 (a)
ARAP2 36
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP15B 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F23H11.4 36
  • 19 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AGE1 36
  • 22 (a)
OneToMany
Species with no ortholog for ARAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARAP2 Gene

ENSEMBL:
Gene Tree for ARAP2 (if available)
TreeFam:
Gene Tree for ARAP2 (if available)

Paralogs for ARAP2 Gene

(3) SIMAP similar genes for ARAP2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ARAP2: view

Variants for ARAP2 Gene

Sequence variations from dbSNP and Humsavar for ARAP2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs4833069 - 36,080,256(+) GAGTT(C/T)GTGAA reference, missense
rs35468501 - 36,210,725(+) TTCTC(A/C)TTTCT reference, missense
rs35218548 - 36,147,731(+) AGCAA(A/G)TAAGG intron-variant, reference, missense
rs984431 -- 36,087,369(-) AGTTA(A/T)ATTTG intron-variant
rs998293 -- 36,141,236(+) ATATT(A/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARAP2 Gene

Variant ID Type Subtype PubMed ID
nsv829905 CNV Gain 17160897
nsv829906 CNV Gain 17160897
nsv461332 CNV Loss 19166990
nsv4300 CNV Loss 18451855
nsv829907 CNV Gain 17160897
nsv509889 CNV Loss 20534489

Variation tolerance for ARAP2 Gene

Residual Variation Intolerance Score: 53.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.88; 67.49% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ARAP2 Gene

Disorders for ARAP2 Gene

Relevant External Links for ARAP2

Genetic Association Database (GAD)
ARAP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARAP2

No disorders were found for ARAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARAP2 Gene

Publications for ARAP2 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus. (PMID: 25130324) Cai D.C. … Hagoort P. (Genes Brain Behav. 2014) 3
  4. The Arf6 GTPase-activating proteins ARAP2 and ACAP1 define distinct endosomal compartments that regulate integrin I+5I^1 traffic. (PMID: 25225293) Chen P.W. … Randazzo P.A. (J. Biol. Chem. 2014) 3
  5. Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1. (PMID: 22959728) . … Zheng J.G. (Neurobiol. Aging 2013) 3

Products for ARAP2 Gene

Sources for ARAP2 Gene

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