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Aliases for ARAP2 Gene

Aliases for ARAP2 Gene

  • ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 2 2 3 5
  • Centaurin-Delta-1 3 4
  • CENTD1 3 4
  • Arf-GAP With Rho-GAP Domain, ANK Repeat And PH Domain-Containing Protein 2 3
  • Arf And Rho GAP Adapter Protein 2 3
  • Centaurin, Delta 1 2
  • Protein PARX 4
  • KIAA0580 4
  • Cnt-D1 4
  • PARX 3

External Ids for ARAP2 Gene

Previous HGNC Symbols for ARAP2 Gene

  • CENTD1

Previous GeneCards Identifiers for ARAP2 Gene

  • GC04M035744
  • GC04M036067
  • GC04M035394

Summaries for ARAP2 Gene

Entrez Gene Summary for ARAP2 Gene

  • The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]

GeneCards Summary for ARAP2 Gene

ARAP2 (ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 2) is a Protein Coding gene. Among its related pathways are Arf6 signaling events and p75 NTR receptor-mediated signalling. GO annotations related to this gene include GTPase activator activity and phosphatidylinositol-3,4,5-trisphosphate binding. An important paralog of this gene is ARAP3.

UniProtKB/Swiss-Prot for ARAP2 Gene

  • Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity).

Gene Wiki entry for ARAP2 Gene

Additional gene information for ARAP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARAP2 Gene

Genomics for ARAP2 Gene

Regulatory Elements for ARAP2 Gene

Enhancers for ARAP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H036280 1.6 FANTOM5 Ensembl ENCODE dbSUPER 17.4 -39.5 -39480 6 PKNOX1 TBL1XR1 BACH1 BMI1 BATF RELA EED FOS ATF7 ETV6 DTHD1 LOC439933 ARAP2 LOC105374399
GH04H036310 0.9 Ensembl ENCODE 26.2 -66.5 -66457 1 MAX REST GABPA POLR2A EED ETV6 MYC RUNX3 ARAP2 LOC439933 DTHD1 LOC105374399
GH04H036325 1.3 FANTOM5 Ensembl ENCODE 17.5 -81.5 -81529 1 PKNOX1 CBFB EBF1 DPF2 RELA POLR2A TARDBP IKZF1 SCRT2 NBN ARAP2 DTHD1 LOC439933 LOC105374399
GH04H036267 1.2 FANTOM5 ENCODE dbSUPER 17.9 -24.3 -24343 2 GATA3 SCRT2 CEBPB CREB1 PRDM10 ATF7 ATF2 DTHD1 LOC439933 ARAP2
GH04H036348 1.1 FANTOM5 ENCODE 19.4 -104.3 -104340 1 PKNOX1 BATF RELA EED HNF4G ATF7 RUNX3 IKZF2 CREM NR2F1 ARAP2 ENSG00000251438 LOC439933 LOC105374399 DTHD1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARAP2 on UCSC Golden Path with GeneCards custom track

Promoters for ARAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000167315 1009 3001 PKNOX1 FOXA2 ZFP64 FEZF1 YY1 GLIS2 FOS KLF7 RUNX3 JUNB

Genomic Location for ARAP2 Gene

Chromosome:
4
Start:
35,948,221 bp from pter
End:
36,244,509 bp from pter
Size:
296,289 bases
Orientation:
Minus strand

Genomic View for ARAP2 Gene

Genes around ARAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARAP2 Gene

Proteins for ARAP2 Gene

  • Protein details for ARAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WZ64-ARAP2_HUMAN
    Recommended name:
    Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
    Protein Accession:
    Q8WZ64
    Secondary Accessions:
    • Q4W5D2
    • Q7Z2L5
    • Q96L70
    • Q96P49
    • Q9Y4E4

    Protein attributes for ARAP2 Gene

    Size:
    1704 amino acids
    Molecular mass:
    193452 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL04166.1; Type=Frameshift; Positions=1579; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARAP2 Gene

neXtProt entry for ARAP2 Gene

Post-translational modifications for ARAP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARAP2 Gene

Domains & Families for ARAP2 Gene

Suggested Antigen Peptide Sequences for ARAP2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARAP2: view

No data available for UniProtKB/Swiss-Prot for ARAP2 Gene

Function for ARAP2 Gene

Molecular function for ARAP2 Gene

UniProtKB/Swiss-Prot Function:
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity).

Phenotypes From GWAS Catalog for ARAP2 Gene

Gene Ontology (GO) - Molecular Function for ARAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA 11804589
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ARAP2: view
genes like me logo Genes that share phenotypes with ARAP2: view

Animal Models for ARAP2 Gene

MGI Knock Outs for ARAP2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ARAP2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARAP2 Gene

Localization for ARAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARAP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARAP2 gene
Compartment Confidence
cytosol 5
nucleus 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
  • Focal adhesion sites (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARAP2: view

Pathways & Interactions for ARAP2 Gene

genes like me logo Genes that share pathways with ARAP2: view

Pathways by source for ARAP2 Gene

1 GeneTex pathway for ARAP2 Gene
1 BioSystems pathway for ARAP2 Gene
1 KEGG pathway for ARAP2 Gene

Gene Ontology (GO) - Biological Process for ARAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARAP2: view

No data available for SIGNOR curated interactions for ARAP2 Gene

Drugs & Compounds for ARAP2 Gene

(1) Drugs for ARAP2 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
genes like me logo Genes that share compounds with ARAP2: view

Transcripts for ARAP2 Gene

mRNA/cDNA for ARAP2 Gene

(7) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARAP2 Gene

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ARAP2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ARAP2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
SP1: -
SP2: -
SP3:
SP4: - - -
SP5:

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for ARAP2 Gene

GeneLoc Exon Structure for
ARAP2
ECgene alternative splicing isoforms for
ARAP2

Expression for ARAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARAP2 Gene

This gene is overexpressed in Prostate (41.5), Bone marrow mesenchymal stem cell (17.3), and Cervix (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARAP2 Gene



NURSA nuclear receptor signaling pathways regulating expression of ARAP2 Gene:

ARAP2

SOURCE GeneReport for Unigene cluster for ARAP2 Gene:

Hs.479451

mRNA Expression by UniProt/SwissProt for ARAP2 Gene:

Q8WZ64-ARAP2_HUMAN
Tissue specificity: Detected in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for ARAP2 Gene

  • Nervous system(4.3)
  • Stomach(3.7)
  • Blood(2)
genes like me logo Genes that share expression patterns with ARAP2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARAP2 Gene

Orthologs for ARAP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARAP2 33 34
  • 99.47 (n)
dog
(Canis familiaris)
Mammalia ARAP2 33 34
  • 89.52 (n)
cow
(Bos Taurus)
Mammalia ARAP2 33 34
  • 89.16 (n)
rat
(Rattus norvegicus)
Mammalia Arap2 33
  • 84.46 (n)
mouse
(Mus musculus)
Mammalia Arap2 33 16 34
  • 84.24 (n)
oppossum
(Monodelphis domestica)
Mammalia ARAP2 34
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARAP2 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARAP2 33 34
  • 68.67 (n)
lizard
(Anolis carolinensis)
Reptilia ARAP2 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arap2 33
  • 61.18 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC559690 33
  • 56.2 (n)
ARAP2 34
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP15B 34
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F23H11.4 34
  • 19 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AGE1 34
  • 22 (a)
OneToMany
Species where no ortholog for ARAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARAP2 Gene

ENSEMBL:
Gene Tree for ARAP2 (if available)
TreeFam:
Gene Tree for ARAP2 (if available)

Paralogs for ARAP2 Gene

(3) SIMAP similar genes for ARAP2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ARAP2: view

Variants for ARAP2 Gene

Sequence variations from dbSNP and Humsavar for ARAP2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000010698 -- 36,184,294(+) TATAT(-/ATAC)ACGTA intron-variant
rs1000013071 -- 36,231,729(+) GATCT(A/G)TCCCT intron-variant
rs1000016546 -- 36,013,927(+) AACCT(A/G)TTGAA intron-variant
rs10000381 -- 36,092,481(+) gcaca(C/T)gcctg intron-variant
rs1000065299 -- 36,216,554(+) GCTAT(G/T)AACAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARAP2 Gene

Variant ID Type Subtype PubMed ID
esv3569373 CNV loss 25503493
esv3600217 CNV loss 21293372
esv3600218 CNV loss 21293372
esv3600219 CNV loss 21293372
esv3600220 CNV gain 21293372
nsv4300 CNV deletion 18451855
nsv461332 CNV loss 19166990
nsv509889 OTHER sequence alteration 20534489
nsv593982 CNV loss 21841781
nsv829905 CNV gain 17160897
nsv829906 CNV gain 17160897
nsv829907 CNV gain 17160897

Variation tolerance for ARAP2 Gene

Residual Variation Intolerance Score: 53.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.88; 67.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARAP2 Gene

Disorders for ARAP2 Gene

Relevant External Links for ARAP2

Genetic Association Database (GAD)
ARAP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARAP2

No disorders were found for ARAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARAP2 Gene

Publications for ARAP2 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 60
  2. ARAP1: a point of convergence for Arf and Rho signaling. (PMID: 11804590) Miura K … Randazzo PA (Molecular cell 2002) 3 4 60
  3. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 60
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 60
  5. The Arf6 GTPase-activating proteins ARAP2 and ACAP1 define distinct endosomal compartments that regulate integrin α5β1 traffic. (PMID: 25225293) Chen PW … Randazzo PA (The Journal of biological chemistry 2014) 3 60

Products for ARAP2 Gene

Sources for ARAP2 Gene

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