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ARAP1 Gene

protein-coding   GIFtS: 58
GCID: GC11M072396

ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain...

(Previous names: centaurin, delta 2)
(Previous symbol: CENTD2)
  Search for ARAP1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 11 2     ARF-GAP, RHO-GAP, Ankyrin Repeat, And Pleckstrin Homology
Domains-Containing Protein 12
CENTD21 2 3 5     centaurin-delta-22
Centaurin, Delta 21 2     cnt-d22
KIAA07823 5     Centaurin-delta-23
Arf-GAP With Rho-GAP Domain, ANK Repeat And PH Domain-Containing Protein 12     Cnt-d23

External Ids:    HGNC: 169251   Entrez Gene: 1169852   Ensembl: ENSG000001866357   OMIM: 6066465   UniProtKB: Q96P483   

Export aliases for ARAP1 gene to outside databases

Previous GC identifers: GC11M072073 GC11M068691


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARAP1 Gene:
The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin
homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate
(PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity
mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific
trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Sep 2008)

GeneCards Summary for ARAP1 Gene:
ARAP1 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1) is a protein-coding gene. GO annotations related to this gene include ARF GTPase activator activity and phosphatidylinositol-3,4,5-trisphosphate binding. An important paralog of this gene is AGAP5.

UniProtKB/Swiss-Prot: ARAP1_HUMAN, Q96P48
Function: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin
cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol
3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate
(PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity)

Gene Wiki entry for ARAP1 (CENTD2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARAP1 gene promoter:
         AREB6   AhR   CREB   PPAR-alpha   SREBP-1a   RREB-1   deltaCREB   Chx10   AP-4   SREBP-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARAP1 promoter sequence
   Search Chromatin IP Primers for ARAP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.3

ARAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARAP1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M072396:  view genomic region     (about GC identifiers)

Start:
72,396,114 bp from pter      End:
72,504,644 bp from pter
Size:
108,531 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARAP1_HUMAN, Q96P48 (See protein sequence)
Recommended Name: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1  
Size: 1450 amino acids; 162192 Da
Subunit: Interacts with TNFRSF10A
Sequence caution: Sequence=BAA34502.2; Type=Erroneous initiation; Sequence=BAD92710.1; Type=Erroneous initiation;
Secondary accessions: A3KLL7 B2RTS2 O94879 Q4LDD5 Q59FI7 Q6PHS3 Q8WU51 Q96HP6 Q96L71
Alternative splicing: 7 isoforms:  Q96P48-6   Q96P48-1   Q96P48-2   Q96P48-3   Q96P48-4   Q96P48-5   Q96P48-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARAP1: NX_Q96P48

Explore proteomics data for ARAP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys631
  • Modification sites at PhosphoSitePlus

  • See ARAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001035207.1  NP_001128662.1  NP_056057.2  

    ENSEMBL proteins: 
     ENSP00000352332   ENSP00000377230   ENSP00000335506   ENSP00000377233   ENSP00000392264  
     ENSP00000403127   ENSP00000441741   ENSP00000442746   ENSP00000411452   ENSP00000399118  
     ENSP00000390461  
    Reactome Protein details: Q96P48

    ARAP1 Human Recombinant Protein Products:

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    Novus Biologicals ARAP1 Lysate
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    Browse Sino Biological Cell Lysates
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    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ARAP1 

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    Search eBioscience for ELISAs for ARAP1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    ANKRD: Ankyrin repeat domain containing
    ArfGAP: ADP-ribosylation factor GTPase activating proteins
    SAMD: Sterile alpha motif (SAM) domain containing

    Selected InterPro protein domains (see all 9):
     IPR021129 SAM_type1
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR001164 ArfGAP
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q96P48

    ProtoNet protein and cluster: Q96P48

    4 Blocks protein domains:
    IPB000159 RA domain
    IPB000198 RhoGAP domain
    IPB001164 HIV Rev interacting protein signature
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: ARAP1_HUMAN, Q96P48
    Similarity: Contains 1 Arf-GAP domain
    Similarity: Contains 4 PH domains
    Similarity: Contains 1 Ras-associating domain
    Similarity: Contains 1 Rho-GAP domain
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Find genes that share domains with ARAP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARAP1_HUMAN, Q96P48
    Function: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin
    cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol
    3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate
    (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity ----
    GO:0005100Rho GTPase activator activity IDA11804590
    GO:0005515protein binding IPI15607035
    GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding IDA11804589
    GO:0008060ARF GTPase activator activity IDA11804590
         
    Find genes that share ontologies with ARAP1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARAP1:
     Decreased focal adhesion (FA)   Decreased viability 

         1 MGI phenotypic allele for Arap1 (no phenotypes)

    Find genes that share phenotypes with ARAP1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARAP1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARAP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARAP1

    miRNA
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    miRTarBase miRNAs that target ARAP1:
    hsa-mir-18a-3p (MIRT040872), hsa-mir-484 (MIRT042346)

    Block miRNA regulation of human, mouse, rat ARAP1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate ARAP1:
    hsa-miR-656 hsa-miR-4271 hsa-miR-1265 hsa-miR-3202 hsa-miR-296-5p hsa-let-7f-2* hsa-miR-4287
    SwitchGear 3'UTR luciferase reporter plasmidARAP1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ARAP1
    Predesigned siRNA for gene silencing in human, mouse, rat ARAP1

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): ARAP1 (NM_015242)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARAP1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARAP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARAP1_HUMAN, Q96P48: Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell
    membrane. Note=Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion
    in cells that are in the process of attaching to a surface and spreading
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    plasma membrane5
    cytosol4
    endosome2
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005794Golgi apparatus IDA--
    GO:0005802trans-Golgi network IEA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--

    Find genes that share ontologies with ARAP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARAP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.58
    3Ras signaling pathway
    Rap1 signaling pathway0.36
    4Regulation of RhoA activity
    Regulation of RhoA activity
    5Endocytosis
    Endocytosis


    Find genes that share SuperPaths with ARAP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ARAP1
        Regulation of RhoA activity

    1 Reactome Pathway for ARAP1
        Rho GTPase cycle


    2 Kegg Pathways  (Kegg details for ARAP1):
        Rap1 signaling pathway
    Endocytosis

        Pathway & Disease-focused RT2 Profiler PCR Array including ARAP1: 
              Cytoskeleton Regulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ARAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for ARAP1 (Q96P481, 2, 3 ENSP000003772334) via UniProtKB, MINT, STRING, and/or I2D (see all 607)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XRCC6P129561, 2, 3EBI-710003,EBI-353208 MINT-7945693 MINT-65245 I2D: score=5 
    TNFRSF10AO002201, 3, ENSP000002211324EBI-710003,EBI-518861 I2D: score=1 STRING: ENSP00000221132
    ARIH2O953762, 3MINT-63305 I2D: score=5 
    TAB1Q157502, 3MINT-8259987 I2D: score=2 
    WAPALQ7Z5K22, 3, ENSP000002987674MINT-7945693 I2D: score=1 STRING: ENSP00000298767
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001921positive regulation of receptor recycling IEA--
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0008360regulation of cell shape IMP11804590
    GO:0030037actin filament reorganization involved in cell cycle TAS11804590

    Find genes that share ontologies with ARAP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARAP1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARAP1 gene (3 alternative transcripts): 
    NM_001040118.2  NM_001135190.1  NM_015242.4  

    Unigene Cluster for ARAP1:

    ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
    Hs.503165  [show with all ESTs]
    Unigene Representative Sequence: NM_001040118
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000495878 ENST00000359373(uc001osv.3) ENST00000465814(uc001osr.3)
    ENST00000393605 ENST00000334211(uc001oss.3 uc009yth.3 uc010rre.2)
    ENST00000393609(uc001osu.3) ENST00000426523 ENST00000429686 ENST00000544721
    ENST00000542596 ENST00000536885 ENST00000541623 ENST00000542612 ENST00000544958
    ENST00000543868 ENST00000536993 ENST00000546293 ENST00000427971
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate ARAP1:
    hsa-miR-656 hsa-miR-4271 hsa-miR-1265 hsa-miR-3202 hsa-miR-296-5p hsa-let-7f-2* hsa-miR-4287
    SwitchGear 3'UTR luciferase reporter plasmidARAP1 3' UTR sequence
    Inhib. RNA
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ARAP1 (NM_015242)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARAP1
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ARAP1
      QuantiFast Probe-based Assays in human, mouse, rat ARAP1

    Additional mRNA sequence: 

    AB018325.2 AF411983.1 AJ621557.1 AK125753.1 AY049732.1 AY553630.1 BC008315.1 BC021244.2 
    BC056401.1 BC127799.1 BC140792.1 BC144562.1 BC150585.1 XR_110891.2 XR_111206.2 XR_171905.1 

    23 DOTS entries:

    DT.91804748  DT.100789413  DT.448474  DT.100789412  DT.86849233  DT.91767933  DT.100789415  DT.120679795 
    DT.204446  DT.91767934  DT.95145844  DT.91999113  DT.100738085  DT.100829590  DT.120679807  DT.91920651 
    DT.92020021  DT.92058022  DT.95145833  DT.95145834  DT.91767937  DT.91935729  DT.95145848 

    Selected AceView cDNA sequences (see all 303):

    BM713933 BI518631 BI752962 BU630120 BQ718561 BM554299 BE279687 BX431030 
    BI061077 AF411983 CK819022 AB018325 CK819021 BC008315 BM998379 CD626853 
    BC056401 BI771300 BQ052804 BF928040 BE819007 AA351870 BU145918 BX459126 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARAP1 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c ^
    SP1:                          -                                                                 -     -                 -     -                                 
    SP2:                                                                                            -     -                 -     -                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                      -     -     -                 -     -                                 
    SP5:                                                                                                  -                 -     -                                 

    ExUns: 23 ^ 24 ^ 25a · 25b · 25c ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b ^ 33 ^ 34a · 34b ^ 35 ^ 36 ^ 37 ^ 38a · 38b
    SP1:                                                                                -           -                                       
    SP2:                                                                                -           -                                       
    SP3:                                                                                -     -     -                                       
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for ARAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGTTCCCCG
    ARAP1 Expression
    About this image

    ARAP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARAP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.503165

    UniProtKB/Swiss-Prot: ARAP1_HUMAN, Q96P48
    Tissue specificity: Detected in heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood
    leukocytes, adrenal gland, bone marrow, brain, lymph node, mammary gland, prostate, spinal cord, stomach, thyroid
    and trachea

        Pathway & Disease-focused RT2 Profiler PCR Array including ARAP1: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARAP1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arap11 , 5 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain more1, 5 85.79(n)1
    90.04(a)1
      7 (54.56 cM)5
    697101  NM_001040111.11  NP_001035200.11 
     1013480675 
    lizard
    (Anolis carolinensis)
    Reptilia ARAP16
    ArfGAP with RhoGAP domain, ankyrin repeat and PH d...
    69(a)
    1 ↔ 1
    GL343633.1(46026-125485)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003325261 arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing more 63.11(n)
    60.3(a)
      100332526  XM_002667212.3  XP_002667258.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGAP15B6
    RhoGAP15B
    16(a)
    1 → many
    X(16837752-16850028)
    worm
    (Caenorhabditis elegans)
    Secernentea F23H11.46
    Protein F23H11.4, isoform a
    19(a)
    1 → many
    III(902212-907539) WBGene00017760
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AGE16
    ADP-ribosylation factor (ARF) GTPase activating pr...
    20(a)
    1 → many
    IV(1487542-1488990) YDR524C


    ENSEMBL Gene Tree for ARAP1 (if available)
    TreeFam Gene Tree for ARAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARAP1 gene
    AGAP52  AGAP62  ASAP12  ARAP32  ACAP22  ACAP32  ASAP22  AGAP32  
    ARAP22  AGAP22  AGAP42  AGAP12  AGAP82  ACAP12  AGAP72  AGAP102  
    AGAP92  ASAP32  
    7 SIMAP similar genes for ARAP1 using alignment to 7 protein entries:     ARAP1_HUMAN (see all proteins):
    FLJ00357    ARAP2    ARFGAP3    FAM13A    ARAP3    ARFGAP1
    ARHGAP21

    Find genes that share paralogs with ARAP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARAP1 (see all 1346)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1492486851,2
    C,Funtested172421563(+) CGCTAG/AAGAGC 6 /S /F mis12Minor allele frequency- A:0.00NA EU 5835
    rs127928291,2
    C,F--72395615(+) GGCCAG/CGCAGT 3 -- ds50015Minor allele frequency- C:0.12NA WA 126
    rs1160683241,2
    C--72395824(+) ACTCAC/GACTCG 3 -- ds50010--------
    rs1499929091,2
    --72395915(+) GGATAA/GTACAA 3 -- ds50010--------
    rs1924168781,2
    --72396093(+) TTAGCC/TAATCA 3 -- ds50010--------
    rs1460533021,2
    --72396217(+) AGGAAA/GGCTGA 3 -- ut310--------
    rs1394572431,2
    --72396355(+) CCTTCC/TGGCAG 3 -- ut310--------
    rs1839752701,2
    --72396438(+) CCCACA/CAGGAC 3 -- ut310--------
    rs1877625181,2
    C--72396617(+) CCCCCC/TGCTGG 3 -- ut310--------
    rs360940951,2
    C,F--72396653(+) GGGTGT/ACTGAA 3 -- ut314Minor allele frequency- A:0.02NA EU 575

    HapMap Linkage Disequilibrium report for ARAP1 (72396114 - 72504644 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ARAP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832207CNV Loss17160897
    nsv468636CNV Loss19166990
    nsv523601CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for ARAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606646    OMIM disorders: --


    Find genes that share disorders with ARAP1           About GenesLikeMe

    Genetic Association Database (GAD): ARAP1
    Human Genome Epidemiology (HuGE) Navigator: ARAP1 (5 documents)

    Export disorders for ARAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARAP1 gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with ARAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. (PubMed id 21873549)1, 4 Strawbridge R.J....Florez J.C. (Diabetes 2011)
    2. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. (PubMed id 20581827)1, 4 Voight B.F.... . (Nat. Genet. 2010)
    3. Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane. (PubMed id 18165900)1, 2 Simova S.... Andera L. (Apoptosis 2008)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. ARAP1: a point of convergence for Arf and Rho signaling. (PubMed id 11804590)1, 2 Miura K.... Randazzo P.A. (Mol. Cell 2002)
    7. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    8. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    9. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. (PubMed id 22446963)1 Okada Y....Yamamoto K. (Nat. Genet. 2012)
    10. Angiotensin AT1 receptor-associated protein Arap1 in the kidney vasculature is suppressed by angiotensin II. (PubMed id 22357923)1 Doblinger E....Castrop H. (Am. J. Physiol. Renal Physiol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 116985 HGNC: 16925 AceView: CENTD2 Ensembl:ENSG00000186635 euGenes: HUgn116985
    ECgene: ARAP1 Kegg: 116985 H-InvDB: ARAP1

    (According to HUGE)
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    HUGE: KIAA0782

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARAP1 gene:
    Search GeneIP for patents involving ARAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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