Aliases for ARAP1 Gene
- ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 1 2 3
- CENTD2 3 4 6
- Centaurin, Delta 2 2 3
- Centaurin-Delta-2 3 4
- KIAA0782 4 6
- Cnt-D2 3 4
- ARF-GAP, RHO-GAP, Ankyrin Repeat, And Pleckstrin Homology Domains-Containing Protein 1 3
- Arf-GAP With Rho-GAP Domain, ANK Repeat And PH Domain-Containing Protein 1 3
External Ids for ARAP1 Gene
Previous Symbols for ARAP1 Gene
The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
GeneCards Summary for ARAP1 Gene
ARAP1 (ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 1) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Signaling by GPCR. GO annotations related to this gene include phosphatidylinositol-3,4,5-trisphosphate binding. An important paralog of this gene is ASAP3.
UniProtKB/Swiss-Prot for ARAP1 Gene
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity).