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Aliases for ARAP1 Gene

Aliases for ARAP1 Gene

  • ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 1 2 3
  • CENTD2 3 4 6
  • Centaurin, Delta 2 2 3
  • Centaurin-Delta-2 3 4
  • KIAA0782 4 6
  • Cnt-D2 3 4
  • ARF-GAP, RHO-GAP, Ankyrin Repeat, And Pleckstrin Homology Domains-Containing Protein 1 3
  • Arf-GAP With Rho-GAP Domain, ANK Repeat And PH Domain-Containing Protein 1 3

External Ids for ARAP1 Gene

Previous HGNC Symbols for ARAP1 Gene

  • CENTD2

Previous GeneCards Identifiers for ARAP1 Gene

  • GC11M072073
  • GC11M072396
  • GC11M068691

Summaries for ARAP1 Gene

Entrez Gene Summary for ARAP1 Gene

  • The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

GeneCards Summary for ARAP1 Gene

ARAP1 (ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 1) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Signaling by GPCR. GO annotations related to this gene include phosphatidylinositol-3,4,5-trisphosphate binding. An important paralog of this gene is ASAP3.

UniProtKB/Swiss-Prot for ARAP1 Gene

  • Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity).

Gene Wiki entry for ARAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARAP1 Gene

Genomics for ARAP1 Gene

Regulatory Elements for ARAP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARAP1 Gene

Start:
72,685,069 bp from pter
End:
72,793,599 bp from pter
Size:
108,531 bases
Orientation:
Minus strand

Genomic View for ARAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARAP1 Gene

Proteins for ARAP1 Gene

  • Protein details for ARAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P48-ARAP1_HUMAN
    Recommended name:
    Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
    Protein Accession:
    Q96P48
    Secondary Accessions:
    • A3KLL7
    • B2RTS2
    • O94879
    • Q4LDD5
    • Q59FI7
    • Q6PHS3
    • Q8WU51
    • Q96HP6
    • Q96L71

    Protein attributes for ARAP1 Gene

    Size:
    1450 amino acids
    Molecular mass:
    162192 Da
    Quaternary structure:
    • Interacts with TNFRSF10A.
    SequenceCaution:
    • Sequence=BAA34502.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92710.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ARAP1 Gene

neXtProt entry for ARAP1 Gene

Proteomics data for ARAP1 Gene at MOPED

Post-translational modifications for ARAP1 Gene

  • Ubiquitination at Lys631
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARAP1 Gene

Domains for ARAP1 Gene

Gene Families for ARAP1 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
  • ArfGAP :ADP-ribosylation factor GTPase activating proteins
  • PLEKH :Pleckstrin homology (PH) domain containing
  • SAMD :Sterile alpha motif (SAM) domain containing

Suggested Antigen Peptide Sequences for ARAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96P48

UniProtKB/Swiss-Prot:

ARAP1_HUMAN :
  • Q96P48
Domain:
  • Contains 1 Arf-GAP domain.
  • Contains 4 PH domains.
  • Contains 1 Ras-associating domain.
  • Contains 1 Rho-GAP domain.
  • Contains 1 SAM (sterile alpha motif) domain.
genes like me logo Genes that share domains with ARAP1: view

Function for ARAP1 Gene

Molecular function for ARAP1 Gene

UniProtKB/Swiss-Prot Function: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity).

Gene Ontology (GO) - Molecular Function for ARAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA 11804590
GO:0005515 protein binding IPI 15607035
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA 11804589
GO:0008270 zinc ion binding IEA --
GO:0031702 type 1 angiotensin receptor binding IEA --
genes like me logo Genes that share ontologies with ARAP1: view

Phenotypes for ARAP1 Gene

GenomeRNAi human phenotypes for ARAP1:
genes like me logo Genes that share phenotypes with ARAP1: view

Animal Model Products

CRISPR Products

miRNA for ARAP1 Gene

miRTarBase miRNAs that target ARAP1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARAP1 Gene

Localization for ARAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARAP1 Gene

Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane. Note=Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion in cells that are in the process of attaching to a surface and spreading.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARAP1 Gene COMPARTMENTS Subcellular localization image for ARAP1 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 5
cytosol 4
endosome 2
nucleus 2

Gene Ontology (GO) - Cellular Components for ARAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005794 Golgi apparatus IDA --
GO:0005802 trans-Golgi network IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with ARAP1: view

Pathways for ARAP1 Gene

genes like me logo Genes that share pathways with ARAP1: view

Pathways by source for ARAP1 Gene

1 BioSystems pathway for ARAP1 Gene
2 KEGG pathways for ARAP1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ARAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001921 positive regulation of receptor recycling IEA --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0008360 regulation of cell shape IMP 11804590
GO:0030037 actin filament reorganization involved in cell cycle TAS 11804590
genes like me logo Genes that share ontologies with ARAP1: view

Transcripts for ARAP1 Gene

Unigene Clusters for ARAP1 Gene

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARAP1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ARAP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARAP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c ^
SP1: - - - - -
SP2: - - - -
SP3:
SP4: - - - - -
SP5: - - -
SP6:
SP7:
SP8: - -
SP9:
SP10:
SP11:

ExUns: 23 ^ 24 ^ 25a · 25b · 25c ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b ^ 33 ^ 34a · 34b ^ 35 ^ 36 ^ 37 ^ 38a · 38b
SP1: - -
SP2: - -
SP3: - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for ARAP1 Gene

GeneLoc Exon Structure for
ARAP1
ECgene alternative splicing isoforms for
ARAP1

Expression for ARAP1 Gene

mRNA expression in normal human tissues for ARAP1 Gene

mRNA differential expression in normal tissues according to GTEx for ARAP1 Gene

This gene is overexpressed in Whole Blood (8.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARAP1 Gene

SOURCE GeneReport for Unigene cluster for ARAP1 Gene Hs.503165

mRNA Expression by UniProt/SwissProt for ARAP1 Gene

Q96P48-ARAP1_HUMAN
Tissue specificity: Detected in heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes, adrenal gland, bone marrow, brain, lymph node, mammary gland, prostate, spinal cord, stomach, thyroid and trachea.
genes like me logo Genes that share expressions with ARAP1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ARAP1 Gene

Orthologs for ARAP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARAP1 35
  • 99.36 (n)
  • 99.52 (a)
ARAP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARAP1 35
  • 88.37 (n)
  • 89.72 (a)
ARAP1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARAP1 35
  • 88.38 (n)
  • 89.8 (a)
ARAP1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arap1 35
  • 85.79 (n)
  • 90.04 (a)
Arap1 16
Arap1 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARAP1 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARAP1 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arap1 35
  • 85.6 (n)
  • 89.01 (a)
lizard
(Anolis carolinensis)
Reptilia ARAP1 36
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ARAP1 (1 of 4) 36
  • 43 (a)
OneToMany
ARAP1 (2 of 4) 36
  • 59 (a)
OneToMany
ARAP1 (3 of 4) 36
  • 60 (a)
OneToMany
ARAP1 (4 of 4) 36
  • 65 (a)
OneToMany
LOC100332526 35
  • 63.11 (n)
  • 60.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP15B 36
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F23H11.4 36
  • 19 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AGE1 36
  • 20 (a)
OneToMany
Species with no ortholog for ARAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARAP1 Gene

ENSEMBL:
Gene Tree for ARAP1 (if available)
TreeFam:
Gene Tree for ARAP1 (if available)

Paralogs for ARAP1 Gene

Selected SIMAP similar genes for ARAP1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ARAP1: view

Variants for ARAP1 Gene

Sequence variations from dbSNP and Humsavar for ARAP1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs624030 -- 72,748,483(+) CCACC(A/G)CACTT intron-variant
rs728847 -- 72,705,688(-) GAGAC(A/C)CTTTG intron-variant
rs729120 -- 72,723,073(+) GAGGT(C/T)GAGGC intron-variant, upstream-variant-2KB
rs730783 -- 72,704,923(+) CAGAA(A/C)AGTCC intron-variant
rs745995 -- 72,723,026(+) TAGGG(G/T)GCCGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARAP1 Gene

Variant ID Type Subtype PubMed ID
nsv832207 CNV Loss 17160897
nsv523601 CNV Loss 19592680
nsv468636 CNV Loss 19166990

Relevant External Links for ARAP1 Gene

HapMap Linkage Disequilibrium report
ARAP1
Human Gene Mutation Database (HGMD)
ARAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARAP1 Gene

Disorders for ARAP1 Gene

Relevant External Links for ARAP1

Genetic Association Database (GAD)
ARAP1
Human Genome Epidemiology (HuGE) Navigator
ARAP1
genes like me logo Genes that share disorders with ARAP1: view

No data available for UniProtKB/Swiss-Prot for ARAP1 Gene

Publications for ARAP1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  2. ARAP1: a point of convergence for Arf and Rho signaling. (PMID: 11804590) Miura K. … Randazzo P.A. (Mol. Cell 2002) 3 4
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane. (PMID: 18165900) Simova S. … Andera L. (Apoptosis 2008) 3 4

Products for ARAP1 Gene

Sources for ARAP1 Gene

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