Aliases for ARAP1 Gene
External Ids for ARAP1 Gene
Previous HGNC Symbols for ARAP1 Gene
Previous GeneCards Identifiers for ARAP1 Gene
The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
GeneCards Summary for ARAP1 Gene
ARAP1 (ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 1) is a Protein Coding gene. Diseases associated with ARAP1 include kidney hypertrophy. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include GTPase activator activity and type 1 angiotensin receptor binding. An important paralog of this gene is ARAP3.
UniProtKB/Swiss-Prot for ARAP1 Gene
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity).