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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ARAP1 Gene

protein-coding GIFtS: 55
GCID: GC11M072396

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain...

(Previous names: centaurin, delta 2 )
(Previous symbol: CENTD2)

Explore 5 diseases affiliated with
ARAP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 1¹ ²		ARF-GAP, RHO-GAP, Ankyrin Repeat, And Pleckstrin Homology Domains-Containing Protein 1²
CENTD2¹ ² ³ ⁵		Centaurin-Delta-2¹
Centaurin, Delta 2¹ ²		Cnt-D2¹
KIAA0782³ ⁵		Centaurin-Delta-2¹
Arf-GAP With Rho-GAP Domain, ANK Repeat And PH Domain-Containing Protein 1²		Cnt-D2¹

External Ids:	HGNC: 16925¹	Entrez Gene: 116985²	Ensembl: ENSG00000186635⁷	OMIM: 606646⁵	UniProtKB: Q96P48³

Export aliases for ARAP1 gene to outside databases

Previous GC identifers: GC11M072073 GC11M068691

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARAP1:

The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin

homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate

(PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates

changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a

receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for

this gene. (provided by RefSeq, Sep 2008)

UniProtKB/Swiss-Prot: ARAP1_HUMAN, Q96P48

Function: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin

cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol

3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate

(PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity)

Gene Wiki entry for ARAP1 (CENTD2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ARAP1 gene promoter:
AREB6 AhR CREB PPAR-alpha SREBP-1a RREB-1 deltaCREB Chx10 AP-4 SREBP-1b
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ARAP1 promoter sequence

Search SABiosciences Chromatin IP Primers for ARAP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARAP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4 Ensembl cytogenetic band: 11q13.4 HGNC cytogenetic band: 11q13.3

ARAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARAP1 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M072396: view genomic region (about GC identifiers)

Start:	72,396,114 bp from pter	End:	72,504,644 bp from pter
Size:	108,531 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ARAP1_HUMAN, Q96P48 (See protein sequence)

Recommended Name: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

Size: 1450 amino acids; 162192 Da

Subunit: Interacts with TNFRSF10A

Subcellular location: Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane.

Note=Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion in cells that

are in the process of attaching to a surface and spreading

Sequence caution: Sequence=BAA34502.2; Type=Erroneous initiation; Sequence=BAD92710.1; Type=Erroneous initiation;

Secondary accessions: A3KLL7 B2RTS2 O94879 Q4LDD5 Q59FI7 Q6PHS3 Q8WU51 Q96HP6 Q96L71

Alternative splicing: 7 isoforms: Q96P48-6 Q96P48-1 Q96P48-2 Q96P48-3 Q96P48-4 Q96P48-5 Q96P48-7 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARAP1: NX_Q96P48

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96P48

ARAP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001035207.1 NP_001128662.1 NP_056057.2

ENSEMBL proteins:

ENSP00000352332 ENSP00000377230 ENSP00000335506 ENSP00000377233 ENSP00000392264

ENSP00000403127 ENSP00000441741 ENSP00000442746 ENSP00000411452 ENSP00000399118

ENSP00000390461

Reactome Protein details: Q96P48
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	Browse Proteins at Uscn

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005794	Golgi apparatus	IDA	11804590
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	IEA	--
GO:0032580	Golgi cisterna membrane	IEA	--

ARAP1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ARAP1 for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR013761 SAM/pointed

IPR001660 SAM

IPR021129 SAM_type1

IPR008936 Rho_GTPase_activation_prot

IPR001849 Pleckstrin_homology

Graphical View of Domain Structure for InterPro Entry Q96P48

ProtoNet protein and cluster: Q96P48

4 Blocks protein families:

IPB000159 RA domain

IPB000198 RhoGAP domain

IPB001164 HIV Rev interacting protein signature

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: ARAP1_HUMAN, Q96P48

Similarity: Contains 1 Arf-GAP domain

Similarity: Contains 4 PH domains

Similarity: Contains 1 Ras-associating domain

Similarity: Contains 1 Rho-GAP domain

Similarity: Contains 1 SAM (sterile alpha motif) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ARAP1_HUMAN, Q96P48

Function: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin

cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol

3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate

(PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity)

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARAP1

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005096	GTPase activator activity	--	--
GO:0005100	Rho GTPase activator activity	IDA	11804590
GO:0005515	protein binding	IPI	18165900
GO:0005543	phospholipid binding	--	--
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	IDA	11804589

ARAP1 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for ARAP1:

Decreased focal adhesion (FA)

Decreased viability

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell death signalling via NRAGE, NRIF and NADE

Signaling by Rho GTPases

0.25

Rho GTPase cycle

0.25

Regulation of RhoA activity

Regulation of RhoA activity

1.00

Endocytosis

Endocytosis

1.00

Signaling by GPCR

Signal Transduction

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for ARAP1

Regulation of RhoA activity

3 Reactome Pathways for ARAP1

	Signaling by Rho GTPases
	Signal Transduction
	Rho GTPase cycle

1 Kegg Pathway (Kegg details for ARAP1):

Endocytosis

ARAP1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ARAP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/577 Interacting proteins for ARAP1 (Q96P48^{1, 2, 3} ENSP00000377233⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 577)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
XRCC6	P12956¹^,²^,³	EBI-710003,EBI-2843064 MINT-7945693 MINT-65245 I2D: score=5
TNFRSF10A	O00220¹^,³, ENSP00000221132⁴	EBI-710003,EBI-518861 I2D: score=1 STRING: ENSP00000221132
ARIH2	O95376²^,³	MINT-63305 I2D: score=5
TAB1	Q15750²^,³	MINT-8259987 I2D: score=2
WAPAL	Q7Z5K2²^,³, ENSP00000298767⁴	MINT-7945693 I2D: score=1 STRING: ENSP00000298767

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	--	--
GO:0007264	small GTPase mediated signal transduction	TAS	--
GO:0008360	regulation of cell shape	IMP	11804590
GO:0030037	actin filament reorganization involved in cell cycle	TAS	11804590
GO:0032312	regulation of ARF GTPase activity	IEA	--

ARAP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ARAP1
Search CenterWatch for drugs/clinical trials and news about ARAP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ARAP1 gene (3 alternative transcripts):

NM_001040118.2 NM_001135190.1 NM_015242.4

Unigene Cluster for ARAP1:

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

Hs.503165 [show with all ESTs]

Unigene Representative Sequence: NM_001040118

18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):

ENST00000495878 ENST00000359373(uc001osv.3) ENST00000465814(uc001osr.3)

ENST00000393605 ENST00000334211(uc001oss.3 uc009yth.3 uc010rre.2)

ENST00000393609(uc001osu.3) ENST00000426523 ENST00000429686 ENST00000544721

ENST00000542596 ENST00000536885 ENST00000541623 ENST00000542612 ENST00000544958

ENST00000543868 ENST00000536993 ENST00000546293 ENST00000427971

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		hsa-miR-656 hsa-miR-4271 hsa-miR-1265 hsa-miR-3202 hsa-miR-296-5p hsa-let-7f-2* hsa-miR-4287
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Additional cDNA sequence:

AB018325.2 AF411983.1 AJ621557.1 AK125753.1 AY049732.1 AY553630.1 BC008315.1 BC021244.2

BC056401.1 BC127799.1 BC140792.1 BC144562.1 BC150585.1 XR_110891.2 XR_111206.2 XR_171905.1

23 DOTS entries:

DT.91804748 DT.100789413 DT.448474 DT.100789412 DT.86849233 DT.91767933 DT.100789415 DT.120679795

DT.204446 DT.91767934 DT.95145844 DT.91999113 DT.100738085 DT.100829590 DT.120679807 DT.91920651

DT.92020021 DT.92058022 DT.95145833 DT.95145834 DT.91767937 DT.91935729 DT.95145848

24/303 AceView cDNA sequences (see all 303):

BI752962 BC056401 BM998379 BC008315 CD626853 BI771300 BF928040 BQ052804

BU145918 BX459126 AW131240 BM982110 BC021244 BU738760 BM126138 BQ056545

CR612600 BQ921498 AY049732 BX396999 NM_015242 AW576474 BG910790 AA328099

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ARAP1 (see all 11) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22a	·	22b	·	22c	^
SP1:									-																						-		-						-		-
SP2:																															-		-						-		-
SP3:
SP4:																													-		-		-						-		-
SP5:																																	-						-		-

ExUns:	23	^	24	^	25a	·	25b	·	25c	^	26	^	27	^	28	^	29	^	30a	·	30b	^	31	^	32a	·	32b	^	33	^	34a	·	34b	^	35	^	36	^	37	^	38a	·	38b
SP1:																											-				-
SP2:																											-				-
SP3:																											-		-		-
SP4:
SP5:

ECgene alternative splicing isoforms for ARAP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ARAP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGTTCCCCG

About this image
See ARAP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARAP1

SOURCE GeneReport for Unigene cluster: Hs.503165

UniProtKB/Swiss-Prot: ARAP1_HUMAN, Q96P48

Tissue specificity: Detected in heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood

leukocytes, adrenal gland, bone marrow, brain, lymph node, mammary gland, prostate, spinal cord, stomach, thyroid and

trachea

SABiosciences Expression via Pathway-Focused PCR Array including ARAP1:

Cytoskeleton Regulators in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ARAP1 gene from 3/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	ARAP1⁶	--	71(a)	1 ↔ 1	GL343633.1(46026-124693)
zebrafish (Danio rerio)	Actinopterygii	LOC100332526¹	arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing more	62.22(n) 59.35(a)		100332526 XM_002667212.2 XP_002667258.2
worm (Caenorhabditis elegans)	Secernentea	cnt-1⁶ cnt-2⁶	CeNTaurin family member (cnt-2)	9(a) 8(a)	possible ortholog 1 ↔ many	II(12072006-12088797) III(10655671-10677423)

ENSEMBL Gene Tree for ARAP1 (if available)
TreeFam Gene Tree for ARAP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ARAP1 gene

AGAP5² AGAP6² ASAP1² ACAP2² ARAP3² GIT2² ACAP3² ASAP2²

AGAP3² GIT1² ARAP2² AGAP2² AGAP4² AGAP1² AGAP8² ACAP1²

AGAP7² AGAP10² AGAP9² ASAP3²

7 SIMAP similar genes for ARAP1 using alignment to 7 protein entries: ARAP1_HUMAN (see all proteins):

FLJ00357 ARAP2 ARFGAP3 FAM13A ARAP3 ARFGAP1

ARHGAP21

ARAP1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs149248685^1,2	C,F,	other	72421563(+)	`CGCTAG/AAGAGC`	6	/S /F	mis¹		2		NA EU	5835
rs77642908^1,2		--	68705222(+)	`GGGAGC/TTGGGA`	1	--	us2k¹		0	--	--	--	--
rs80123537^1,2	C,	--	68705362(+)	`CAGGTA/CCAGCC`	1	--	us2k¹		0	--	--	--	--
rs59363870^1,2	C,F,	--	68706470(+)	`TGTACC/TGTTCA`	1	--	us2k¹		1		WA	118
rs78415614^1,2	C,F,	--	68706744(+)	`TCTGTG/AAGGGC`	1	--	us2k¹		1		WA	118
rs71477741^1,2	C,F	--	68706970(+)	`AGTACG/ATTAAT`	1	--	int¹		2		NA	4
rs60461936^1,2	C,	--	68707478(+)	`GACGAC/TGTGTC`	1	--	int¹		2		WA	120
rs114879235^1,2	C,F,	--	68709072(+)	`CCAAGC/TACACC`	1	--	int¹		1		WA	118
rs11827386^1,2	C,H	--	68709713(+)	`GGGGGC/GGGGTG`	1	--	int¹ trp³		1		CSA	1
rs78057584^1,2	C,F,	--	68709838(+)	`CAGGAC/TGCCTG`	1	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for ARAP1 (72396114 - 72504644 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ARAP1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ARAP1 for disorders           About GeneDecksing

OMIM gene information: 606646    OMIM disorders: --

5 diseases for ARAP1:    About MalaCards

kidney hypertrophy hepatitis c hepatitis thyroiditis

prostatitis

Human Genome Epidemiology (HuGE) Navigator: ARAP1 (5 documents)

Export disorders for ARAP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ARAP1 gene, integrated from 9 sources (see all 39):
(articles sorted by number of sources associating them with ARAP1)

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world of online information

Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane. (PubMed id 18165900)^{1, 2} Simova S.... Andera L. (2008)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
ARAP1: a point of convergence for Arf and Rho signaling. (PubMed id 11804590)^{1, 2} Miura K.... Randazzo P.A. (2002)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (2002)
Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)^{1, 2} Nagase T.... Ohara O. (1998)
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. (PubMed id 22446963)¹ Okada Y....Yamamoto K. (2012)
Angiotensin AT1 receptor-associated protein Arap1 in t he kidney vasculature is suppressed by angiotensin II. (PubMed id 22357923)¹ Doblinger E....Castrop H. (2012)
ARAP1 regulates the ring size of circular dorsal ruffl es through Arf1 and Arf5. (PubMed id 22573888)¹ Hasegawa J....Itoh T. (2012)
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resi stance. (PubMed id 22581228)¹ Manning A.K....Langenberg C. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 116985	HGNC: 16925	AceView: CENTD2	Ensembl:ENSG00000186635	euGenes: HUgn116985
ECgene: ARAP1	Kegg: 116985	H-InvDB: ARAP1

(According to HUGE)
About This Section

HUGE: KIAA0782

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ARAP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ARAP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ARAP1 gene:
Search GeneIP for patents involving ARAP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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