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ARAF Gene

protein-coding GIFtS: 62

GC0XP047305

v-raf murine sarcoma 3611 viral oncogene homolog
(Previous name: v-raf murine sarcoma 3611 viral oncogene homolog 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ARAF1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
A-RAF ^²
A-raf-1 ^³
ARAF1 ^², ³
EC 2.7.11.1 ^³
OTTHUMP00000023212 ^²
PKS ^³
PKS2 ^², ³
RAFA1 ^²

Descriptions
Oncogene ARAF1 ^²
Proto-oncogene Pks ^³
Ras-binding protein DA-Raf ^²
v-raf murine sarcoma 3611 viral oncogene homolog ^²
v-raf murine sarcoma 3611 viral oncogene homolog 1 ^¹, ²

External Ids
HGNC: 646¹
Entrez Gene: 369²
UniProtKB: P10398³
Ensembl: ENSG00000078061⁷

Search outside databases for aliases for ARAF gene

Previous GC identifer: GC0XP047177

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ARAF_HUMAN, P10398

Function: Involved in the transduction of mitogenic signals from the cell membrane to the nucleus

Gene Wiki entry for ARAF

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ARAF gene

Entrez Gene cytogenetic band: Xp11.4-p11.2 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.3-p11.23

ARAF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP047305: (about GC identifiers)

Start:	47,305,522 bp from pter
End:	47,316,264 bp from pter
Size:	10,743 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000023.9 NT_079573.3

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ARAF_HUMAN, P10398 (See protein sequence)

Recommended Name: A-Raf proto-oncogene serine/threonine-protein kinase

Size: 606 amino acids; 67585 Da

Cofactor: Binds 2 zinc ions per subunit (By similarity)

Subunit: Interacts with TH1L/NELFD

PDB structures from and Proteopedia :

1WXM (3D)

Secondary accessions: P07557 Q5H9B3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001645.1

ENSEMBL proteins:

ENSP00000366238 ENSP00000366244 ENSP00000290277

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (A RAF)
	Human Recombinant Proteins from Abnova (ARAF)

OriGene Purified Recombinant Human Protein: ARAF

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--

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Antibodies for ARAF:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ARAF
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for ARAF
	Antibodies from Abcam (A RAF), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ARAF)
	Novus Biologicals Antibodies for ARAF

Assays for ARAF:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P10398

ProtoNet protein and cluster: P10398

2 Blocks protein families:

IPB002219 Protein kinase C

IPB003116 Raf-like Ras-binding

UniProtKB/Swiss-Prot: ARAF_HUMAN, P10398

Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF

subfamily

Similarity: Contains 1 phorbol-ester/DAG-type zinc finger

Similarity: Contains 1 protein kinase domain

Similarity: Contains 1 RBD (Ras-binding) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ARAF)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ARAF)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001654

Applied Biosystems Silencer® siRNAs for ARAF

Sigma-Aldrich siRNA and siRNA Panels for ARAF

Sigma-Aldrich shRNA Panels and shRNA for ARAF

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ARAF
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001654
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001654
untagged cDNA clones in CMV expression vector (see all 3): BC009028

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001654

UniProtKB/Swiss-Prot: ARAF_HUMAN, P10398

Function: Involved in the transduction of mitogenic signals from the cell membrane to the nucleus

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme Number (IUBMB): EC 2.7.11.1

7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Araf):

behavior/neurological	digestive/alimentary	growth/size	hematopoietic system	immune system
lethality-postnatal	muscle

5/9 Gene Ontology (GO) molecular function terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004674	protein serine/threonine kinase activity	NAS	--
GO:0005057	receptor signaling protein activity	IEA	--
GO:0005515	protein binding	IPI	11909642 12620389 17353931
GO:0005524	ATP binding	NAS	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for ARAF (Your Favorite Gene powered by Ingenuity) (see all 7 )

ERK/MAPK Signaling
Acute Myeloid Leukemia Signaling
IL-8 Signaling
Endothelin-1 Signaling
Nicotinate and Nicotinamide Metabolism

GeneDecks ARAF for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ARAF

5/45 Interacting proteins for ARAF (ENSP00000290277³ P10398^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 45 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAP2K2	P36507¹	STRING (score=.988) EBI-365961, EBI-1056930
RRAS2	P62070¹	STRING (score=.974) EBI-365961, EBI-491037
TIMM44	O43615¹	STRING (score=.867) EBI-365961, EBI-861737
PIK3R1	P27986²	STRING (score=.915) MINT-16107 MINT-16108 MINT-16109
PRPF6	O94906¹^,²	STRING (score=.867) EBI-365961, EBI-536755 MINT-19319 EBI-365961, EBI-536755 MINT-19319

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006464	protein modification process	TAS	3029685
GO:0006468	protein amino acid phosphorylation	NAS	--
GO:0007242	intracellular signaling cascade	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for ARAF available from Tocris Bioscience

Compound	Action	CAS number
ZM 336372	Potent, selective c-Raf inhibitor	[208260-29-1]
GW 5074	Potent, selective c-Raf1 kinase inhibitor	[220904-83-6]
L-779,450	Potent Raf kinase inhibitor	[303727-31-3]

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10/23 Novoseek chemical compound relationships for ARAF gene (see all 23 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
6-deoxyerythronolide b	91.96	16	15885088 (1), 17328673 (1), 8652546 (1), 11939803 (1) (see all 12)
10-deoxymethynolide	89.62	1	11223265 (1)
pikromycin	88.24	7	10713461 (1), 17565713 (1), 18245260 (1), 18512859 (1)
methymycin	87.45	1	17565713 (1)
narbonolide	84.67	1	11223265 (1)
n-acetylcysteamine	83.31	1	11439032 (1)
tetracenomycin	77.99	5	15260498 (4)
mycolactone	77.60	7	18840298 (2), 17031885 (2), 15758215 (1)
vibriobactin	73.26	1	15366944 (1)
chalcone	64.77	5	11006298 (1), 11774005 (1), 11732902 (1), 11959984 (1) (see all 5)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ARAF)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ARAF)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001654

Sigma-Aldrich siRNA and siRNA Panels for ARAF

Sigma-Aldrich shRNA Panels and shRNA for ARAF

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001654

REFSEQ mRNAs for ARAF gene:

NM_001654.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001654

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001654
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001654
                                 untagged cDNA clones in CMV expression vector (see all 3): BC009028

Additional cDNA sequence:

AB158254.1 AF052136.1 AK130043.1 AK297453.1 AK300975.1 AK307747.1 BC002466.2 BC007514.2

BT019864.1 CR605071.1 M13829.1 X04790.1

23 DOTS entries:

DT.102836980 DT.100812399 DT.100658177 DT.100812408 DT.448494 DT.121285030 DT.121285068 DT.100812404

DT.100812402 DT.92058039 DT.121285038 DT.97862004 DT.100812395 DT.95108590 DT.121285071 DT.95245717

DT.100812400 DT.121285049 DT.121285078 DT.91640785 DT.91684943 DT.100835282 DT.99996839

24/323 AceView cDNA sequences (see all 323 ):

X04790 AI700898 N76413 AW674355 CD724043 BM713862 BE383829 BF931458

BQ955304 BF435683 AI422711 BP346188 BM461996 F13363 AI760277 BM906467

BE378713 BU733087 AK130043 AA332774 BQ929597 BC007514 CD359377 CA424869

highest scoring ESTs for ARAF:

AA015618 AA114161 AA182638 AA182732 AA236603 AA332774 AA454735 AA477696 AA570700 AA573455

Unigene Cluster for ARAF:

V-raf murine sarcoma 3611 viral oncogene homolog

Hs.446641 [show with all ESTs]

Unigene Representative Sequence: X04790

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ARAF (see all 9 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b	^	9a	·	9b	·	9c	·	9d	^	10	^	11	^	12	^	13	^	14	^
SP1:									-		-						-		-		-								-				-		-
SP2:																	-		-		-								-				-		-
SP3:									-		-						-		-		-								-				-
SP4:									-		-						-		-		-								-
SP5:									-		-						-				-

ExUns:	15	^	16	^	17	^	18
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ARAF

3 Ensembl transcripts including schematic representations:

ENST00000377039 ENST00000377045 ENST00000290277

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ARAF expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ARAF

¹ / ² / ³

8 probe-sets matching ARAF gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
58393_at²^{, 3}	U95-C	1	1.00	1.00	-0.25	0.64	AI760277	0.60	1.00	0.82	1
1706_at²^{, 3}	U95-A	1	1.00	1.00	0.79	1.27	U01337	0.20	1.00	0.72	1
1707_g_at²^{, 3}	U95-A	2	1.00	0.97	0.64	1.17	U01337	0.20	1.00	0.72	1
73633_at*²^{, 3}	U95-D	1	--	--	0.81	0.95	AI939528	0.40	1.00	0.76	1
201895_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001654	0.60	1.00	0.82	1
230652_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI760277	0.60	1.00	0.82	1
201895_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
230652_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ARAF for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGGATTTTGG

SOURCE GeneReport for Unigene cluster: Hs.446641
Expression variation in blood from EXPOLDB for ARAF
UniProtKB/Swiss-Prot: ARAF_HUMAN, P10398
Tissue specificity: Predominantly in urogenital tissues (By similarity)

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ARAF gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ARAF¹	--	v-raf murine sarcoma 3611 viral oncogene homolog	91.79(n) 93.97(a)	491857 XM_548976.2 XP_548976.2
cow (Bos taurus)	ARAF¹	--	v-raf murine sarcoma 3611 viral oncogene homolog	92.9(n) 96.53(a)	540421 NM_001014964.1 NP_001014964.1
rat (Rattus norvegicus)	Araf¹	--	v-raf murine sarcoma 3611 viral oncogene homolog	90.62(n) 95.86(a)	64363 NM_022532.2 NP_071977.1
mouse (Mus musculus)	Araf^{1, 5}	X (6.20 cM)⁵	v-raf murine sarcoma 3611 viral oncogene homolog^{1, 5}	90.29(n)¹ 95.53(a)¹	11836¹ NM_009703.1¹ NP_033833.1¹ AA960102⁵ AB158252⁵ (see all 23)
zebrafish (Danio rerio)	zgc:92074¹	--	zgc:92074	65.62(n) 71.01(a)	403063 NM_205743.1 NP_991306.1

About this table Species with no ortholog for ARAF

ENSEMBL Gene Tree for ARAF

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ARAF gene

RAF1² BRAF²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/137 NCBI SNPs in ARAF are shown (see all 137 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 41)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs12556182^1,2	A,C	47305373(+)	`GCGCTA/TGCCCC`	1	--	ng5¹		0	--	--	--	--
	rs1050133^1,2	H	47314281(+)	`GCTTCC/TAGTCA`	1	Q/X	non¹ ese³		4		EU EA WA	398
--	rs11551157^1,2	H	47307603(+)	`CGACTC/TTCTAG`	1	S/F	mis¹ ese³		4		EU EA WA	378
	rs1130962^1,2	C	47314347(+)	`ACAGCC/TACATT`	1	H/Y	mis¹		0	--	--	--	--
	rs2071777^1,2	A,C,F,H	47308743(-)	`AGGAAA/CCCCAC`	1	--	int¹		8		EU EA WA	626
	rs2854412^1,2	A,C,F,H	47315401(+)	`CTGGGA/TTAGAG`	1	--	int¹		4		EU EA WA	412
	rs2071776^1,2	A,C,F,H	47309559(-)	`GACACG/AGGTCA`	1	--	int¹		8		EU EA WA	628
	rs2854426^1,2	A,C,F,H	47312538(+)	`acctgC/Gtgagg`	1	--	int¹		7		EA WA NA	494
	rs2858769^1,2	A,C,F,H	47315109(-)	`GTACTG/ATCAGT`	1	--	int¹		12		EU EA WA	939
	rs2283736^1,2	C,F,H	47306345(-)	`CCAAGC/ACTCTA`	1	--	int¹		8		EU EA WA	728

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HapMap Linkage Disequilibrium images for ARAF (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 311010

3 Novoseek disease relationships for ARAF gene

Disease	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tuberculosis	1	15042094 (1)
aids	1	11251290 (1)
ovarian cancer	2	16332724 (2)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/171 PubMed articles for ARAF gene (see all 171 ):

The complete sequence and promoter activity of the human A-raf-1 gene (ARAF1). (PubMed id 8020955)^{1, 3, 4} Lee J.-E.... Rapp U.R. (1994)
Identification of TH1 as an interaction partner of A-Raf kinase. (PubMed id 11952167)^{1, 3, 4} Yin X.L.... Gu J.X. (2002)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{3, 4} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirus. (PubMed id 3029685)^{3, 4} Beck T.W.... Rapp U.R. (1987)
Pks, a raf-related sequence in humans. (PubMed id 3529082)^{3, 4} Mark G.E.... Mountz J.D. (1986)
Identification of key residues in the A-Raf kinase important for phosphoinositide lipid binding specificity. (PubMed id 15736953)^{1, 3} Johnson L.M....Anderson D.H. (2005)
A-Raf associates with and regulates platelet-derived growth factor receptor signalling. (PubMed id 15763428)^{1, 3} Mahon E.S....Anderson D.H. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 369	HGNC: 646	AceView: ARAF1	Ensembl:ENSG00000078061	euGenes: HUgn369
ECgene: ARAF	H-InvDB: ARAF

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ARAF	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ARAF
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ARAF:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ARAF-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ARAF		Antibodies for ARAF
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ARAF		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ARAF)
	Antibodies (ARAF)
	Chimera RNAi (ARAF)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for ARAF

	Recombinant Proteins (A RAF)
	Antibodies (A RAF)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for ARAF

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Antibodies for ARAF

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ARAF Gene at Home site.
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ARAF Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for ARAF

Summaries
for ARAF

Genomic Location
for ARAF

Proteins
for ARAF

Protein Domains/
Families
for ARAF

Gene Function
for ARAF

Pathways & Interactions
for ARAF

Drugs & Compounds
for ARAF

Transcripts
for ARAF

Expression
for ARAF

Orthologs
for ARAF

Paralogs
for ARAF

SNPs/Variants
for ARAF

Disorders & Mutations
for ARAF

Medical News
for ARAF

Publications
for ARAF

Search for ARAF

Genome Databases showing ARAF

Other Databases showing ARAF

Specialized Databases showing ARAF

Licensable Technologies
for ARAF

Services
for ARAF

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ARAF Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor ARAF

Summariesfor ARAF

Genomic Locationfor ARAF

Proteinsfor ARAF

Protein Domains/Familiesfor ARAF

Gene Functionfor ARAF

Pathways & Interactionsfor ARAF

Drugs & Compoundsfor ARAF

Transcriptsfor ARAF

Expression for ARAF

Orthologsfor ARAF

Paralogsfor ARAF

SNPs/Variantsfor ARAF

Disorders & Mutationsfor ARAF

Medical Newsfor ARAF

Publicationsfor ARAF

Search for ARAF

Genome Databases showing ARAF

Other Databases showing ARAF

Specialized Databases showing ARAF

Licensable Technologiesfor ARAF

Servicesfor ARAF

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ARAF

Summaries
for ARAF

Genomic Location
for ARAF

Proteins
for ARAF

Protein Domains/
Families
for ARAF

Gene Function
for ARAF

Pathways & Interactions
for ARAF

Drugs & Compounds
for ARAF

Transcripts
for ARAF

Expression
for ARAF

Orthologs
for ARAF

Paralogs
for ARAF

SNPs/Variants
for ARAF

Disorders & Mutations
for ARAF

Medical News
for ARAF

Publications
for ARAF

Licensable Technologies
for ARAF

Services
for ARAF