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Aliases for ARAF Gene

Aliases for ARAF Gene

  • A-Raf Proto-Oncogene, Serine/Threonine Kinase 2 3 5
  • V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog 1 2 3
  • Proto-Oncogene A-Raf-1 3 4
  • Proto-Oncogene Pks 3 4
  • EC 2.7.11.1 4 61
  • ARAF1 3 4
  • PKS2 3 4
  • V-Raf Murine Sarcoma 3611 Viral Oncogene-Like Protein 3
  • A-Raf Proto-Oncogene Serine/Threonine-Protein Kinase 3
  • Serine/Threonine-Protein Kinase A-Raf 3
  • Ras-Binding Protein DA-Raf 3
  • Proto-Oncogene A-Raf 4
  • Oncogene ARAF1 3
  • EC 2.7.11 61
  • A-RAF 3
  • RAFA1 3
  • PKS 4

External Ids for ARAF Gene

Previous HGNC Symbols for ARAF Gene

  • ARAF1

Previous GeneCards Identifiers for ARAF Gene

  • GC0XP047177
  • GC0XP047305
  • GC0XP047429
  • GC0XP045132

Summaries for ARAF Gene

Entrez Gene Summary for ARAF Gene

  • This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]

CIViC summary for ARAF Gene

  • ARAF has recently become increasingly considered for its oncogenic potential. Its potential as a target for informing clinical action was demonstrated by a single case of advanced lung adenocarcinoma harboring an S214C mutation that, when treated with sorafenib, acheived near-complete clinical remission. This finding has brought new focus on ARAF as a marker that should be assayed for in cancer treatment.

GeneCards Summary for ARAF Gene

ARAF (A-Raf Proto-Oncogene, Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with ARAF include Pallister-Killian Syndrome and Mycobacterium Marinum. Among its related pathways are mTOR Pathway and GPCR Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RAF1.

UniProtKB/Swiss-Prot for ARAF Gene

  • Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade.

  • Isoform 2: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation.

Tocris Summary for ARAF Gene

  • Raf kinases, a family of three serine/threonine kinases, are part of the Ras-MAPK signaling cascade and phosphorylate MEK. Upon growth factor stimulation, Raf-1 (c-Raf) is activated by GTP-bound Ras and recruited to the cell membrane. This activation process is tightly regulated.

Gene Wiki entry for ARAF Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARAF Gene

Genomics for ARAF Gene

Regulatory Elements for ARAF Gene

Enhancers for ARAF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG047128 1.3 Ensembl ENCODE 11 -431.5 -431500 2.0 PKNOX1 ATF1 ARID4B SIN3A FEZF1 DMAP1 BRCA1 ZNF2 YY1 TCF12 LOC100113397 NUS1P1 ARAF ZNF182 ZNF81 INE1 GC0XP047145 LOC105373193
GH0XG047559 1.4 FANTOM5 ENCODE 9.4 +1.3 1330 5.4 HDGF PKNOX1 CREB3L1 ARNT SIN3A DMAP1 ZNF2 YY1 ZNF766 FOS LINC01560 CFP ZNF182 ZNF630 ARAF CDK16 GC0XP047572 GC0XP047571
GH0XG047632 1.6 FANTOM5 Ensembl ENCODE 6.9 +72.8 72827 3.2 HDGF PKNOX1 ZSCAN4 FEZF1 YBX1 RELB IKZF2 EGR2 CEBPB ZEB2 CFP ARAF UXT-AS1 ELK1
GH0XG047555 1.5 FANTOM5 Ensembl ENCODE 5.6 -4.6 -4612 1.7 TBP PKNOX1 KLF17 SIN3A GLIS2 SCRT2 FOS SP3 NFYA SMAD5 ARAF NUS1P1
GH0XG047578 1.3 FANTOM5 Ensembl ENCODE 4.9 +18.4 18386 1.8 TBP ZNF792 MAX ZNF316 FOS MAFK NFE2L2 TCF7L2 ZNF740 CEBPB CFP ARAF TIMP1 GC0XP047573
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARAF on UCSC Golden Path with GeneCards custom track

Promoters for ARAF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000246421 100 2001 HDGF PKNOX1 CREB3L1 ARNT SIN3A DMAP1 ZNF2 YY1 FOS SP3

Genomic Location for ARAF Gene

Chromosome:
X
Start:
47,561,100 bp from pter
End:
47,571,921 bp from pter
Size:
10,822 bases
Orientation:
Plus strand

Genomic View for ARAF Gene

Genes around ARAF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARAF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARAF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARAF Gene

Proteins for ARAF Gene

  • Protein details for ARAF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10398-ARAF_HUMAN
    Recommended name:
    Serine/threonine-protein kinase A-Raf
    Protein Accession:
    P10398
    Secondary Accessions:
    • P07557
    • Q5H9B2
    • Q5H9B3

    Protein attributes for ARAF Gene

    Size:
    606 amino acids
    Molecular mass:
    67585 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with TH1L/NELFD.

    Three dimensional structures from OCA and Proteopedia for ARAF Gene

    Alternative splice isoforms for ARAF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARAF Gene

Selected DME Specific Peptides for ARAF Gene

P10398:
  • GSVLWMA
  • NILLFMG
  • FHQHCSS
  • RDQIIFMVGRGYLSPDLSK
  • NPYSFQSDVYA
  • TVKIGDFGLATVK
  • TQWCEGSSLY
  • RSASEPSL
  • RKTFFSL
  • HNFVRKTF
  • ARQTAQGMDYLHAK
  • ERPLFPQIL
  • LPNKQRTVV
  • WHGDVAVK
  • GFRCQTCGYKFH
  • KSNNIFLH

Post-translational modifications for ARAF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ARAF (ARAF)
  • Abcam antibodies for ARAF

Domains & Families for ARAF Gene

Graphical View of Domain Structure for InterPro Entry

P10398

UniProtKB/Swiss-Prot:

ARAF_HUMAN :
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
genes like me logo Genes that share domains with ARAF: view

Function for ARAF Gene

Molecular function for ARAF Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade.
UniProtKB/Swiss-Prot Function:
Isoform 2: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation.

Enzyme Numbers (IUBMB) for ARAF Gene

Gene Ontology (GO) - Molecular Function for ARAF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA,TAS 3029685
GO:0004674 protein serine/threonine kinase activity IEA,IDA 19667065
GO:0004709 MAP kinase kinase kinase activity IBA,IEA --
GO:0005057 signal transducer activity, downstream of receptor IEA --
genes like me logo Genes that share ontologies with ARAF: view
genes like me logo Genes that share phenotypes with ARAF: view

Animal Models for ARAF Gene

MGI Knock Outs for ARAF:

Animal Model Products

miRNA for ARAF Gene

miRTarBase miRNAs that target ARAF

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARAF

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARAF Gene

Localization for ARAF Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARAF gene
Compartment Confidence
cytosol 5
mitochondrion 3
nucleus 3
plasma membrane 1
extracellular 1

Gene Ontology (GO) - Cellular Components for ARAF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IBA,IEA --
GO:0005829 cytosol IEA,TAS --
genes like me logo Genes that share ontologies with ARAF: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARAF Gene

Pathways & Interactions for ARAF Gene

SuperPathway Contained pathways
1 RET signaling
2 Glioma
.47
.41
3 Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
4 IL-2 Pathway
5 GPCR Pathway
genes like me logo Genes that share pathways with ARAF: view

SIGNOR curated interactions for ARAF Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for ARAF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity IEA --
GO:0006464 cellular protein modification process TAS 3029685
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with ARAF: view

Drugs & Compounds for ARAF Gene

(29) Drugs for ARAF Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra Target 0
regorafenib Approved Pharma inhibitor Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Sorafenib Approved, Investigational Pharma inhibitors, inhibitor Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 700
XL281 Investigational Pharma inhibitor Kinase Inhibitors 0
LGX818 Pharma Inhibition, inhibitor RAF inhibitor,potent and selective, RAF inhibitor, Kinase Inhibitors, Pan-RAF Inhibitor 0

(26) Additional Compounds for ARAF Gene - From: Novoseek, Tocris, and HMDB