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Aliases for ARAF Gene

Aliases for ARAF Gene

  • A-Raf Proto-Oncogene, Serine/Threonine Kinase 2 3 5
  • V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog 1 2 3
  • Proto-Oncogene A-Raf-1 3 4
  • Proto-Oncogene Pks 3 4
  • EC 2.7.11.1 4 63
  • ARAF1 3 4
  • PKS2 3 4
  • V-Raf Murine Sarcoma 3611 Viral Oncogene-Like Protein 3
  • A-Raf Proto-Oncogene Serine/Threonine-Protein Kinase 3
  • Ras-Binding Protein DA-Raf 3
  • Proto-Oncogene A-Raf 4
  • Oncogene ARAF1 3
  • EC 2.7.11 63
  • A-RAF 3
  • RAFA1 3
  • PKS 4

External Ids for ARAF Gene

Previous HGNC Symbols for ARAF Gene

  • ARAF1

Previous GeneCards Identifiers for ARAF Gene

  • GC0XP047177
  • GC0XP047305
  • GC0XP047429
  • GC0XP045132

Summaries for ARAF Gene

Entrez Gene Summary for ARAF Gene

  • This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]

GeneCards Summary for ARAF Gene

ARAF (A-Raf Proto-Oncogene, Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with ARAF include pallister-killian syndrome and mycobacterium marinum. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Signaling by GPCR. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is KSR1.

UniProtKB/Swiss-Prot for ARAF Gene

  • Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade.

  • Isoform 2: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation.

Tocris Summary for ARAF Gene

  • Raf kinases, a family of three serine/threonine kinases, are part of the Ras-MAPK signaling cascade and phosphorylate MEK. Upon growth factor stimulation, Raf-1 (c-Raf) is activated by GTP-bound Ras and recruited to the cell membrane. This activation process is tightly regulated.

Gene Wiki entry for ARAF Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARAF Gene

Genomics for ARAF Gene

Regulatory Elements for ARAF Gene

Promoters for ARAF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARAF on UCSC Golden Path with GeneCards custom track

Genomic Location for ARAF Gene

Chromosome:
X
Start:
47,561,100 bp from pter
End:
47,571,921 bp from pter
Size:
10,822 bases
Orientation:
Plus strand

Genomic View for ARAF Gene

Genes around ARAF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARAF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARAF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARAF Gene

Proteins for ARAF Gene

  • Protein details for ARAF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10398-ARAF_HUMAN
    Recommended name:
    Serine/threonine-protein kinase A-Raf
    Protein Accession:
    P10398
    Secondary Accessions:
    • P07557
    • Q5H9B2
    • Q5H9B3

    Protein attributes for ARAF Gene

    Size:
    606 amino acids
    Molecular mass:
    67585 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with TH1L/NELFD.

    Three dimensional structures from OCA and Proteopedia for ARAF Gene

    Alternative splice isoforms for ARAF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARAF Gene

Proteomics data for ARAF Gene at MOPED

Post-translational modifications for ARAF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARAF Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ARAF (ARAF)

Domains & Families for ARAF Gene

Graphical View of Domain Structure for InterPro Entry

P10398

UniProtKB/Swiss-Prot:

ARAF_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
Domain:
  • Contains 1 protein kinase domain.
  • Contains 1 RBD (Ras-binding) domain.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with ARAF: view

Function for ARAF Gene

Molecular function for ARAF Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade.
UniProtKB/Swiss-Prot Function:
Isoform 2: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation.

Enzyme Numbers (IUBMB) for ARAF Gene

genes like me logo Genes that share phenotypes with ARAF: view

Human Phenotype Ontology for ARAF Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ARAF Gene

MGI Knock Outs for ARAF:

Animal Model Products

miRNA for ARAF Gene

miRTarBase miRNAs that target ARAF

No data available for Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for ARAF Gene

Localization for ARAF Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARAF Gene COMPARTMENTS Subcellular localization image for ARAF gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARAF Gene

Pathways & Interactions for ARAF Gene

SuperPathways for ARAF Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 IL-7 Signaling Pathways
3 IL-2 Pathway
4 GPCR Pathway
5 Glioma
.51
.43
genes like me logo Genes that share pathways with ARAF: view

SIGNOR curated interactions for ARAF Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for ARAF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007411 axon guidance TAS --
GO:0008286 insulin receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with ARAF: view

Drugs & Compounds for ARAF Gene

(27) Drugs for ARAF Gene - From: Novoseek, DrugBank, HMDB, ApexBio, Tocris, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra Target 0
regorafenib Approved Pharma inhibitor Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Sorafenib Approved, Investigational Pharma inhibitors, inhibitor Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 671
XL281 Investigational Pharma inhibitor Kinase Inhibitors 0
LGX818 Pharma Inhibition, inhibitor RAF inhibitor,potent and selective, RAF inhibitor, Kinase Inhibitors, Pan-RAF Inhibitor 0

(28) Additional Compounds for ARAF Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with ARAF: view

Transcripts for ARAF Gene

Unigene Clusters for ARAF Gene

V-raf murine sarcoma 3611 viral oncogene homolog:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARAF Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - -
SP9: -

ExUns: 15 ^ 16 ^ 17 ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ARAF Gene

GeneLoc Exon Structure for
ARAF
ECgene alternative splicing isoforms for
ARAF

Expression for ARAF Gene

mRNA expression in normal human tissues for ARAF Gene

Protein differential expression in normal tissues from HIPED for ARAF Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARAF Gene



SOURCE GeneReport for Unigene cluster for ARAF Gene Hs.446641

mRNA Expression by UniProt/SwissProt for ARAF Gene

P10398-ARAF_HUMAN
Tissue specificity: Predominantly in urogenital tissues.
genes like me logo Genes that share expression patterns with ARAF: view

Protein tissue co-expression partners for ARAF Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ARAF Gene

Orthologs for ARAF Gene

This gene was present in the common ancestor of animals.

Orthologs for ARAF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARAF 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARAF 36
  • 96 (a)
OneToOne
ARAF 35
  • 92.9 (n)
  • 96.53 (a)
dog
(Canis familiaris)
Mammalia ARAF 35
  • 93.95 (n)
  • 97.19 (a)
ARAF 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Araf 16
Araf 36
  • 95 (a)
OneToOne
Araf 35
  • 90.29 (n)
  • 95.53 (a)
oppossum
(Monodelphis domestica)
Mammalia ARAF 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARAF 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Araf 35
  • 90.62 (n)
  • 95.86 (a)
lizard
(Anolis carolinensis)
Reptilia ARAF 36
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii araf 36
  • 67 (a)
OneToOne
araf 35
  • 65.62 (n)
  • 71.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta phl 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lin-45 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10630 36
  • 36 (a)
OneToMany
Species with no ortholog for ARAF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARAF Gene

ENSEMBL:
Gene Tree for ARAF (if available)
TreeFam:
Gene Tree for ARAF (if available)

Paralogs for ARAF Gene

(4) SIMAP similar genes for ARAF Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ARAF Gene

genes like me logo Genes that share paralogs with ARAF: view

Variants for ARAF Gene

Sequence variations from dbSNP and Humsavar for ARAF Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs56197559 - 47,564,889(+) GACCA(C/T)GCACA upstream-variant-2KB, reference, missense
VAR_040376 A colorectal adenocarcinoma sample
rs55852926 - 47,571,370(+) ATTGA(C/G)CGGAG reference, missense
rs1130962 -- 47,570,004(+) ACAGC(C/T)ACATT reference, missense
rs1050133 -- 47,569,938(+) GCTTC(C/T)AGTCA reference, stop-gained

Variation tolerance for ARAF Gene

Residual Variation Intolerance Score: 31.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARAF Gene

HapMap Linkage Disequilibrium report
ARAF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARAF Gene

Disorders for ARAF Gene

MalaCards: The human disease database

(4) MalaCards diseases for ARAF Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pallister-killian syndrome
  • pallister killian syndrome
mycobacterium marinum
  • fish tank granuloma
aland island eye disease
  • forsius-eriksson syndrome
adenosquamous cell lung carcinoma
  • adenosquamous lung carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search ARAF in MalaCards View complete list of genes associated with diseases

Relevant External Links for ARAF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARAF
genes like me logo Genes that share disorders with ARAF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARAF Gene

Publications for ARAF Gene

  1. The complete sequence and promoter activity of the human A-raf-1 gene (ARAF1). (PMID: 8020955) Lee J.-E. … Rapp U.R. (Genomics 1994) 3 4 23 67
  2. Heterogeneous nuclear ribonucleoprotein H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription. (PMID: 20145135) Rauch J. … Gires O. (Cancer Res. 2010) 3 23
  3. Identification of key residues in the A-Raf kinase important for phosphoinositide lipid binding specificity. (PMID: 15736953) Johnson L.M. … Anderson D.H. (Biochemistry 2005) 3 23
  4. A-Raf associates with and regulates platelet-derived growth factor receptor signalling. (PMID: 15763428) Mahon E.S. … Anderson D.H. (Cell. Signal. 2005) 3 23
  5. Trihydrophobin 1 is a new negative regulator of A-Raf kinase. (PMID: 14684750) Liu W. … Gu J. (J. Biol. Chem. 2004) 3 23

Products for ARAF Gene