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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARAF Gene

protein-coding   GIFtS: 68
GCID: GC0XP047429

V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog

(Previous name: v-raf murine sarcoma 3611 viral oncogene homolog 1)
(Previous symbol: ARAF1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog1 2     A-RAF2
ARAF11 2 3 5     A-Raf Proto-Oncogene Serine/Threonine-Protein Kinase2
PKS22 3 5     Oncogene ARAF12
V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog 11 2     Ras-Binding Protein DA-Raf2
Proto-Oncogene A-Raf-12 3     Serine/Threonine-Protein Kinase A-Raf2
Proto-Oncogene Pks2 3     PKS3
EC 2.7.11.13 8     Proto-Oncogene A-Raf3
RAFA12 5     EC 2.7.118

External Ids:    HGNC: 6461   Entrez Gene: 3692   Ensembl: ENSG000000780617   OMIM: 3110105   UniProtKB: P103983   

Export aliases for ARAF gene to outside databases

Previous GC identifers: GC0XP047177 GC0XP047305 GC0XP045132


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARAF Gene:
This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell
growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for
this gene.(provided by RefSeq, Jan 2012)

GeneCards Summary for ARAF Gene: 
ARAF (v-raf murine sarcoma 3611 viral oncogene homolog) is a protein-coding gene. Diseases associated with ARAF include noonan syndrome, and chronic myeloid leukemia, and among its related super-pathways are Glioma and ErbB signaling pathway. GO annotations related to this gene include protein serine/threonine kinase activity and receptor signaling protein activity. An important paralog of this gene is FPGT-TNNI3K.

UniProtKB/Swiss-Prot: ARAF_HUMAN, P10398
Function: Involved in the transduction of mitogenic signals from the cell membrane to the nucleus
Function: Isoform 2: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the
expression of myogenin and other muscle-specific proteins, and myotube formation

summary for ARAF Gene:
Raf kinases, a family of three serine/threonine kinases, are part of the ras-MAPK signaling cascade and
phosphorylate MEK. Upon growth factor stimulation, Raf-1 (or c-Raf) is activated by GTP-bound Ras and
recruited to the cell membrane. This activation process is tightly regulated by a number of factors
including phosphatases (e.g. PP1, PP2A, PP5), kinases (e.g. Src, ERK, Akt, PKC) and proteins that bind
directly to Raf-1 (e.g. RKIP, 14-3-3zeta, KSR, Hsp90). Raf-1 is also thought to be able to dimerize with
wild type B-Raf in a Ras-dependent process. B-raf is commonly mutated and thereby activated in many human
cancers, the most frequent mutation being the V600E mutation of the kinase domain. Whilst wt b-Raf and Raf-1
are strongly activated by growth factor signals via Ras and Src, a-Raf is only modestly activated and has
low basal activity. All three isoforms of Raf are considered to be oncogenic.

Gene Wiki entry for ARAF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_079573.4  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARAF gene promoter:
         Elk-1   C/EBPbeta   AP-1   ATF-2   CREB   deltaCREB   Sox9   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARAF promoter sequence
   Search SABiosciences Chromatin IP Primers for ARAF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARAF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.4-p11.2   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.3-p11.23

ARAF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARAF gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP047429:  view genomic region     (about GC identifiers)

Start:
47,420,516 bp from pter      End:
47,431,320 bp from pter
Size:
10,805 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARAF_HUMAN, P10398 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase A-Raf  
Size: 606 amino acids; 67585 Da
Cofactor: Binds 2 zinc ions per subunit (By similarity)
Subunit: Interacts with TH1L/NELFD
1 PDB 3D structure from and Proteopedia for ARAF:
1WXM (3D)    
Secondary accessions: P07557 Q5H9B2 Q5H9B3
Alternative splicing: 2 isoforms:  P10398-1   P10398-2   (Has a wider tissue distribution than isoform 1, and acts as dominant-negative antagonist)

Explore the universe of human proteins at neXtProt for ARAF: NX_P10398

Explore proteomics data for ARAF at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P10398

  • 4/16 DME Specific Peptides for ARAF (P10398) (see all 16)
     NILLFMG  GSVLWMA  FHQHCSS  RKTFFSL 

    ARAF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARAF Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001243125.1  NP_001243126.1  NP_001645.1  

    ENSEMBL proteins: 
     ENSP00000366244   ENSP00000366238   ENSP00000290277  

    Human Recombinant Protein Products for ARAF: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ARAF
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for ARAF 
    OriGene Custom Protein Services for ARAF
    GenScript Custom Purified and Recombinant Proteins Services for ARAF
    Novus Biologicals ARAF Proteins
    Novus Biologicals ARAF Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ARAF 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol IEA--

    ARAF for ontologies           About GeneDecksing



    ARAF Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    GenScript Custom Superior Antibodies Services for ARAF
    Novus Biologicals ARAF Antibodies
    Abcam antibodies for ARAF
    Cloud-Clone Corp. Antibodies for ARAF 
    ThermoFisher Antibody for ARAF
    LSBio Antibodies in human, mouse, rat for ARAF 

    Assay Products for ARAF: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ARAF 
    Cloud-Clone Corp. CLIAs for ARAF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: v-raf murine sarcoma 3611 viral oncogene homolog 
    RAF family

    5/8 InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR020454 DAG/PE-bd
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry P10398

    ProtoNet protein and cluster: P10398

    2 Blocks protein domains:
    IPB002219 Protein kinase C
    IPB003116 Raf-like Ras-binding


    UniProtKB/Swiss-Prot: ARAF_HUMAN, P10398
    Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 RBD (Ras-binding) domain


    ARAF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARAF_HUMAN, P10398
    Function: Involved in the transduction of mitogenic signals from the cell membrane to the nucleus
    Function: Isoform 2: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the
    expression of myogenin and other muscle-specific proteins, and myotube formation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS3029685
    GO:0004674protein serine/threonine kinase activity NAS--
    GO:0004709MAP kinase kinase kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005057receptor signaling protein activity ----
         
    ARAF for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for ARAF:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  G0/1 arrest  Increased G1 DNA content 
     Increased cell death HMECs cel  Increased viability with 4OH t  Synthetic lethal with Ras 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Araf):
     behavior/neurological  digestive/alimentary  growth/size  hematopoietic system  immune system 
     mortality/aging  muscle 

    ARAF for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Araftm1Mmc for ARAF

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ARAF 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ARAF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARAF 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARAF 

    miRNA
    Products:
        
    miRTarBase miRNAs that target ARAF:
    hsa-mir-124 (MIRT004929)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARAF
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate ARAF (see all 20):
    hsa-miR-218 hsa-miR-3190 hsa-miR-520a-5p hsa-miR-124 hsa-miR-342-5p hsa-miR-199b-5p hsa-miR-506 hsa-miR-28-5p
    SwitchGear 3'UTR luciferase reporter plasmidARAF 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ARAF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARAF

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ARAF
    Sirion Biotech Customized adenovirus for overexpression of ARAF

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ARAF (see all 9)
    OriGene ORF clones in mouse, rat for ARAF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARAF (NM_001654)
    Sino Biological Human cDNA Clone for ARAF
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARAF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARAF
    Sirion Biotech Customized lentivirus for stable overexpression of ARAF 
                         Customized lentivirus expression plasmids for stable overexpression of ARAF 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ARAF
    Search LifeMap BioReagents cell lines for ARAF
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARAF


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARAF About   (see all 31)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glioma
    Glioma0.51
    Prostate cancer0.39
    Non-small cell lung cancer0.51
    Signaling Pathways in Glioblastoma0.36
    Melanoma0.43
    Bladder cancer0.31
    2ErbB signaling pathway
    ErbB signaling pathway0.52
    ErbB signaling pathway0.52
    3Sorafenib Pharmacodynamics
    Vemurafenib Pathway, Pharmacodynamics0.37
    VEGF Pathway0.36
    4Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
    IL-9 Signaling Pathways0.90
    IL-15 Signaling Pathways0.88
    IL-7 Signaling Pathways0.90
    IL-2 Signaling Pathways0.88
    IL-21 Signaling Pathways0.90
    IL-4 Signaling Pathways0.84
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    Adipocytokines & Insulin Signaling0.34
    5Endometrial cancer
    Endometrial cancer0.45
    Acute myeloid leukemia0.40
    Colorectal cancer0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for ARAF
        G-protein signaling K-RAS regulation pathway
    G-protein signaling N-RAS regulation pathway
    G-protein signaling M-RAS regulation pathway

    5/10 R&D Systems Pathways for ARAF (see all 10)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling
    IL-7 Signaling Pathways


    1 Cell Signaling Technology (CST) Pathway for ARAF
        MAP Kinase Signaling

    3 Tocris Bioscience Pathways for ARAF
        Insulin Pathway
    VEGF Pathway
    MAPK Pathway

    3 GeneGo (Thomson Reuters) Pathways for ARAF
        G-protein signaling M-RAS regulation pathway
    G-protein signaling K-RAS regulation pathway
    G-protein signaling N-RAS regulation pathway

    5/7 BioSystems Pathways for ARAF (see all 7)
        Focal Adhesion
    EGFR1 Signaling Pathway
    Integrin-mediated cell adhesion
    ErbB signaling pathway
    Integrated Breast Cancer Pathway


    1 PharmGKB Pathway for ARAF
        Vemurafenib Pathway, Pharmacodynamics

    5/24         Kegg Pathways  (Kegg details for ARAF) (see all 24):
        ErbB signaling pathway
    Vascular smooth muscle contraction
    Natural killer cell mediated cytotoxicity
    Long-term potentiation
    Serotonergic synapse


    ARAF for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARAF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/91 Interacting proteins for ARAF (P103981, 2, 3 ENSP000003662444) via UniProtKB, MINT, STRING, and/or I2D (see all 91)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASS1P009661, 2, 3, ENSP000002530044EBI-365961,EBI-536842 MINT-19320 I2D: score=6 STRING: ENSP00000253004
    COPS3Q9UNS21, 2, 3, ENSP000002687174EBI-365961,EBI-350590 MINT-19322 I2D: score=6 STRING: ENSP00000268717
    RABGGTBP536111, 2, 3, ENSP000003174734EBI-365961,EBI-536715 MINT-19316 I2D: score=6 STRING: ENSP00000317473
    NELFCDQ8IXH71, 2, 3, ENSP000003423004EBI-365961,EBI-536725 MINT-19318 I2D: score=5 STRING: ENSP00000342300
    PRPF6O949061, 2, 3, ENSP000002660794EBI-365961,EBI-536755 MINT-19319 I2D: score=5 STRING: ENSP00000266079
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade ----
    GO:0000186activation of MAPKK activity ----
    GO:0006464cellular protein modification process TAS3029685
    GO:0006468protein phosphorylation NAS--
    GO:0007165signal transduction ----

    ARAF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ARAF for compounds           About GeneDecksing

    EMD Millipore small molecules for ARAF:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for ARAF available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GDC 0879Potent B-Raf inhibitor[905281-76-7]
    ZM 336372 Potent, selective c-Raf inhibitor [208260-29-1]
    GW 5074 Potent, selective c-Raf1 kinase inhibitor [220904-83-6]
    SB 590885Potent B-Raf inhibitor[405554-55-4]
    L-779,450 Potent Raf kinase inhibitor[303727-31-3]

    10/845 HMDB Compounds for ARAF (see all 845)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----

    1 DrugBank Compound for ARAF    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine triphosphate5'-ATP (see all 8)56-65-5target--17139284 17016423

    10/38 Novoseek inferred chemical compound relationships for ARAF gene (see all 38)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    6-deoxyerythronolide b 91.8 17 15885088 (1), 17328673 (1), 8652546 (1), 11939803 (1) (see all 13)
    pikromycin 90.1 10 10713461 (1), 17565713 (1), 18245260 (1), 18512859 (1) (see all 5)
    10-deoxymethynolide 89.2 1 11223265 (1)
    methymycin 86.6 1 17565713 (1)
    mycolactone 85.6 8 18840298 (2), 17031885 (2), 15758215 (1), 19383681 (1)
    narbonolide 84.1 1 11223265 (1)
    n-acetylcysteamine 82.4 1 11439032 (1)
    tetracenomycin 77.1 5 15260498 (4)
    candicidin 75.5 6 12664141 (3), 11782498 (1)
    vibriobactin 72.2 1 15366944 (1)

    Search CenterWatch for drugs/clinical trials and news about ARAF

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARAF gene (3 alternative transcripts): 
    NM_001256196.1  NM_001256197.1  NM_001654.4  

    Unigene Cluster for ARAF:

    V-raf murine sarcoma 3611 viral oncogene homolog
    Hs.446641  [show with all ESTs]
    Unigene Representative Sequence: NM_001256196
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377045(uc011mln.2 uc011mlo.2 uc004dic.1 uc011mlp.2)
    ENST00000377039 ENST00000489496 ENST00000469505 ENST00000470206 ENST00000290277

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARAF
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate ARAF (see all 20):
    hsa-miR-218 hsa-miR-3190 hsa-miR-520a-5p hsa-miR-124 hsa-miR-342-5p hsa-miR-199b-5p hsa-miR-506 hsa-miR-28-5p
    SwitchGear 3'UTR luciferase reporter plasmidARAF 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ARAF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARAF
    Clone
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    OriGene clones in human, mouse for ARAF (see all 9)
    OriGene ORF clones in mouse, rat for ARAF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARAF (NM_001654)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARAF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARAF
    Sirion Biotech Customized lentivirus for stable overexpression of ARAF 
                         Customized lentivirus expression plasmids for stable overexpression of ARAF 
    Primer
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    OriGene qPCR primer pairs and template standards for ARAF
    OriGene qSTAR qPCR primer pairs in human, mouse for ARAF
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARAF
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARAF
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARAF

    Additional mRNA sequence: 

    AB158254.1 AF052136.1 AK130043.1 AK297453.1 AK300975.1 AK307747.1 BC002466.2 BC007514.2 
    BT019864.1 M13829.1 X04790.1 

    23 DOTS entries:

    DT.102836980  DT.100812399  DT.100658177  DT.100812408  DT.448494  DT.121285030  DT.100812402  DT.121285068 
    DT.100812404  DT.92058039  DT.121285038  DT.97862004  DT.100812395  DT.95108590  DT.95245717  DT.121285071 
    DT.100812400  DT.121285049  DT.121285078  DT.91640785  DT.91684943  DT.100835282  DT.99996839 

    24/323 AceView cDNA sequences (see all 323):

    CB133046 BQ186143 CB215508 AI760277 BU180722 CD724043 BG392456 AI700898 
    BM906467 BM759611 BC002466 CB250426 N76413 CA307758 AI097075 BM921828 
    BE383829 BU727606 BM461996 BM923943 CD612373 CR605071 F10957 AI066393 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ARAF (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^
    SP1:                          -     -                 -     -     -                       -           -     -                                                   
    SP2:                                                  -     -     -                       -           -     -                                                   
    SP3:                          -     -                 -     -     -                       -           -                                                         
    SP4:                          -     -                 -     -     -                       -                                                                     
    SP5:                          -     -                 -           -                                                                                             

    ExUns: 15 ^ 16 ^ 17 ^ 18
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for ARAF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARAF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGATTTTGG
    ARAF Expression
    About this image


    See ARAF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARAF

    SOURCE GeneReport for Unigene cluster: Hs.446641

    UniProtKB/Swiss-Prot: ARAF_HUMAN, P10398
    Tissue specificity: Predominantly in urogenital tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including ARAF: 
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              EGF / PDGF Signaling Pathway in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ARAF gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Araf1 , 5 v-raf murine sarcoma 3611 viral oncogene homolog1, 5 90.29(n)1
    95.53(a)1
      X (16.30 cM)5
    118361  NM_009703.21  NP_033833.11 
     207978145 
    chicken
    (Gallus gallus)
    Aves RAF16
    RAF proto-oncogene serine/threonine-protein kinase...
    56(a)
    possible ortholog
    12(4943218-4971156)
    lizard
    (Anolis carolinensis)
    Reptilia ARAF6
    RAF16
    Uncharacterized protein
    61(a)
    55(a)
    1 ↔ 1
    possible ortholog
    2(68096241-68132063)
    2(158964683-159074372)
    zebrafish
    (Danio rerio)
    Actinopterygii araf1 v-raf murine sarcoma 3611 viral oncogene homolog 65.62(n)
    71.01(a)
      403063  NM_205743.1  NP_991306.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mlk-16
    lin-456
    (see all 4)
    Raf homolog serine/threonine-protein kinase
    (see all 4)
    8(a)
    30(a)
    (see all 4)
    possible ortholog
    possible ortholog
    (see all 4)
    V(5056379-5064803)
    IV(6742538-6748424)


    ENSEMBL Gene Tree for ARAF (if available)
    TreeFam Gene Tree for ARAF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARAF gene
    FPGT-TNNI3K2  MAP3K122  MAP3K112  KIAA18042  RAF12  KSR22  KSR12  MOS2  
    BRAF2  MAP3K92  MAP3K102  MAP3K72  TNNI3K2  ZAK2  MAP3K132  ILK2  
    4 SIMAP similar genes for ARAF using alignment to 3 protein entries:     ARAF_HUMAN (see all proteins):
    BRAF    RAF1    CDK4    SRGAP3

    ARAF for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for ARAF
    PGOHUM00000232787 PGOHUM00000232806 PGOHUM00000233315


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/329 SNPs in ARAF are shown (see all 329)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0403764
    A colorectal adenocarcinoma sample4--see VAR_0403762 G C mis40--------
    rs1999783541,2
    --47338368(+) GTTGA-/GGCCCC 3 -- us2k10--------
    rs616652401,2
    C--47338369(+) TTGAGC/GCCCCC 3 -- us2k14Minor allele frequency- G:0.17WA NA CSA 6
    rs2010035111,2
    --47338369(+) TGAGG-/CCCCCC 3 -- us2k10--------
    rs732061251,2
    C,F--47338525(+) AATGAG/ATCCTC 3 -- us2k11Minor allele frequency- A:0.00NA 1
    rs1833748291,2
    --47338819(+) GATCCA/GCCCGC 3 -- us2k10--------
    rs1879090301,2
    --47339124(+) AATTGC/TCTTTA 3 -- us2k10--------
    rs1912964081,2
    --47339125(+) ATTGCC/TTTTAT 3 -- us2k10--------
    rs734943991,2
    C--47339151(+) AACTCG/ATATCT 3 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1826629161,2
    --47339163(+) TATGAA/CAAGCA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARAF (47420516 - 47431320 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ARAF: --

    Locus Specific Mutation Databases (LSDB): ARAF
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ARAF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 311010    OMIM disorders: --

    20 diseases for ARAF:    About MalaCards
    noonan syndrome    chronic myeloid leukemia    sarcoma    myeloid leukemia
    acute myeloid leukemia    renal cell carcinoma    hepatitis c    ovarian cancer
    pancreatic cancer    colorectal cancer    glioblastoma    pancreatitis
    lung cancer    leukemia    hepatitis    melanoma
    prostate cancer    adenocarcinoma    prostatitis    breast cancer


    ARAF for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for ARAF gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 2.69 2 20145135 (2)
    aids 0 1 11251290 (1)
    ovarian cancer 0 2 16332724 (2)
    tuberculosis 0 1 15042094 (1)


    Export disorders for ARAF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARAF gene, integrated from 9 sources (see all 197):
    (articles sorted by number of sources associating them with ARAF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The complete sequence and promoter activity of the human A-raf-1 gene (ARAF1). (PubMed id 8020955)1, 2, 9 Lee J.-E.... Rapp U.R. (1994)
    2. Identification of TH1 as an interaction partner of A-Raf kinase. (PubMed id 11952167)1, 2, 9 Yin X.L.... Gu J.X. (2002)
    3. DA-Raf1, a competent intrinsic dominant-negative antagonist of the Ras-ERK pathway, is required for myogenic differentiation. (PubMed id 17535970)1, 2 Yokoyama T.... Endo T. (2007)
    4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirus. (PubMed id 3029685)1, 2 Beck T.W.... Rapp U.R. (1987)
    9. Pks, a raf-related sequence in humans. (PubMed id 3529082)1, 2 Mark G.E.... Mountz J.D. (1986)
    10. Heterogeneous nuclear ribonucleoprotein H blocks MST2 -mediated apoptosis in cancer cells by regulating A-Raf transcription. (PubMed id 20145135)1, 9 Rauch J....Gires O. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 369 HGNC: 646 AceView: ARAF1 Ensembl:ENSG00000078061 euGenes: HUgn369
    ECgene: ARAF Kegg: 369 H-InvDB: ARAF

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARAF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ARAF Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARAF gene:
    Search GeneIP for patents involving ARAF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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