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Aliases for ARAF Gene

Aliases for ARAF Gene

  • A-Raf Proto-Oncogene, Serine/Threonine Kinase 2 3 5
  • V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog 1 2 3
  • Proto-Oncogene A-Raf-1 3 4
  • Proto-Oncogene Pks 3 4
  • EC 2.7.11.1 4 61
  • ARAF1 3 4
  • PKS2 3 4
  • V-Raf Murine Sarcoma 3611 Viral Oncogene-Like Protein 3
  • A-Raf Proto-Oncogene Serine/Threonine-Protein Kinase 3
  • Serine/Threonine-Protein Kinase A-Raf 3
  • Ras-Binding Protein DA-Raf 3
  • Proto-Oncogene A-Raf 4
  • Oncogene ARAF1 3
  • EC 2.7.11 61
  • A-RAF 3
  • RAFA1 3
  • PKS 4

External Ids for ARAF Gene

Previous HGNC Symbols for ARAF Gene

  • ARAF1

Previous GeneCards Identifiers for ARAF Gene

  • GC0XP047177
  • GC0XP047305
  • GC0XP047429
  • GC0XP045132

Summaries for ARAF Gene

Entrez Gene Summary for ARAF Gene

  • This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]

GeneCards Summary for ARAF Gene

ARAF (A-Raf Proto-Oncogene, Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with ARAF include Pallister-Killian Syndrome and Mycobacterium Marinum. Among its related pathways are MAPK Signaling: Oxidative Stress Pathway and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RAF1.

UniProtKB/Swiss-Prot for ARAF Gene

  • Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade.

  • Isoform 2: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation.

Tocris Summary for ARAF Gene

  • Raf kinases, a family of three serine/threonine kinases, are part of the Ras-MAPK signaling cascade and phosphorylate MEK. Upon growth factor stimulation, Raf-1 (c-Raf) is activated by GTP-bound Ras and recruited to the cell membrane. This activation process is tightly regulated.

Gene Wiki entry for ARAF Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARAF Gene

Genomics for ARAF Gene

Regulatory Elements for ARAF Gene

Enhancers for ARAF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ARAF on UCSC Golden Path with GeneCards custom track

Promoters for ARAF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ARAF Gene

Chromosome:
X
Start:
47,561,100 bp from pter
End:
47,571,921 bp from pter
Size:
10,822 bases
Orientation:
Plus strand

Genomic View for ARAF Gene

Genes around ARAF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARAF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARAF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARAF Gene

Proteins for ARAF Gene

  • Protein details for ARAF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10398-ARAF_HUMAN
    Recommended name:
    Serine/threonine-protein kinase A-Raf
    Protein Accession:
    P10398
    Secondary Accessions:
    • P07557
    • Q5H9B2
    • Q5H9B3

    Protein attributes for ARAF Gene

    Size:
    606 amino acids
    Molecular mass:
    67585 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with TH1L/NELFD.

    Three dimensional structures from OCA and Proteopedia for ARAF Gene

    Alternative splice isoforms for ARAF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARAF Gene

Post-translational modifications for ARAF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARAF Gene

Domains & Families for ARAF Gene

Graphical View of Domain Structure for InterPro Entry

P10398

UniProtKB/Swiss-Prot:

ARAF_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
Domain:
  • Contains 1 protein kinase domain.
  • Contains 1 RBD (Ras-binding) domain.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with ARAF: view

Function for ARAF Gene

Molecular function for ARAF Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade.
UniProtKB/Swiss-Prot Function:
Isoform 2: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation.

Enzyme Numbers (IUBMB) for ARAF Gene

Gene Ontology (GO) - Molecular Function for ARAF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 3029685
GO:0004674 protein serine/threonine kinase activity IDA 19667065
GO:0004709 MAP kinase kinase kinase activity IEA --
GO:0005057 receptor signaling protein activity IEA --
GO:0005515 protein binding IEA,IPI 11909642
genes like me logo Genes that share ontologies with ARAF: view
genes like me logo Genes that share phenotypes with ARAF: view

Human Phenotype Ontology for ARAF Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ARAF Gene

MGI Knock Outs for ARAF:

Animal Model Products

CRISPR Products

miRNA for ARAF Gene

miRTarBase miRNAs that target ARAF

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARAF

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for ARAF Gene

Localization for ARAF Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARAF Gene COMPARTMENTS Subcellular localization image for ARAF gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ARAF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol IEA,TAS --
genes like me logo Genes that share ontologies with ARAF: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARAF Gene

Pathways & Interactions for ARAF Gene

SuperPathways for ARAF Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 IL-7 Signaling Pathways
3 IL-2 Pathway
4 Glioma
.51
.43
5 GPCR Pathway
genes like me logo Genes that share pathways with ARAF: view

SIGNOR curated interactions for ARAF Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for ARAF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0006464 cellular protein modification process TAS 3029685
GO:0006468 protein phosphorylation IEA --
GO:0032006 regulation of TOR signaling IMP 22609986
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process IMP 22609986
genes like me logo Genes that share ontologies with ARAF: view

Drugs & Compounds for ARAF Gene

(28) Drugs for ARAF Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra Target 0
regorafenib Approved Pharma inhibitor Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Sorafenib Approved, Investigational Pharma inhibitors, inhibitor Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 681
XL281 Investigational Pharma inhibitor Kinase Inhibitors 0
LGX818 Pharma Inhibition, inhibitor RAF inhibitor,potent and selective, RAF inhibitor, Kinase Inhibitors, Pan-RAF Inhibitor 0

(27) Additional Compounds for ARAF Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(5) Tocris Compounds for ARAF Gene

Compound Action Cas Number
AZ 628 Potent Raf kinase inhibitor 878739-06-1
GDC 0879 Potent B-Raf inhibitor 905281-76-7
GW 5074 Potent, selective c-Raf1 kinase inhibitor 220904-83-6
SB 590885 Potent B-Raf inhibitor 405554-55-4
ZM 336372 Potent, selective c-Raf inhibitor 208260-29-1

(5) ApexBio Compounds for ARAF Gene

Compound Action Cas Number
AZ 628 Raf kinases,potent and ATP-competitive 878739-06-1
CEP-32496 BRAF(V600E)inhibitor,highly potent 1188910-76-0
GDC-0879 B-Raf inhibitor,potent and selective 905281-76-7
LGX818 RAF inhibitor,potent and selective 1269440-17-6
TAK-632 Pan-RAF inhibitor,potent and selective 1228591-30-7
genes like me logo Genes that share compounds with ARAF: view

Transcripts for ARAF Gene

Unigene Clusters for ARAF Gene

V-raf murine sarcoma 3611 viral oncogene homolog:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARAF

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARAF Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - -
SP9: -

ExUns: 15 ^ 16 ^ 17 ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ARAF Gene

GeneLoc Exon Structure for
ARAF
ECgene alternative splicing isoforms for
ARAF

Expression for ARAF Gene

mRNA expression in normal human tissues for ARAF Gene

Protein differential expression in normal tissues from HIPED for ARAF Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARAF Gene



Protein tissue co-expression partners for ARAF Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARAF Gene:

ARAF

SOURCE GeneReport for Unigene cluster for ARAF Gene:

Hs.446641

mRNA Expression by UniProt/SwissProt for ARAF Gene:

P10398-ARAF_HUMAN
Tissue specificity: Predominantly in urogenital tissues.
genes like me logo Genes that share expression patterns with ARAF: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ARAF Gene

Orthologs for ARAF Gene

This gene was present in the common ancestor of animals.

Orthologs for ARAF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARAF 34
  • 92.9 (n)
  • 96.53 (a)
ARAF 35
  • 96 (a)
OneToOne