Free for academic non-profit institutions. Other users need a Commercial license

ARAF Gene(Protein Coding)

A-Raf Proto-Oncogene, Serine/Threonine Kinase

GCID:
GC0XP047562
GIFtS:
64
Genes Participants
UDN Logo

Aliases for ARAF Gene

Aliases for ARAF Gene

  • A-Raf Proto-Oncogene, Serine/Threonine Kinase 2 3 5
  • V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog 1 2 3
  • Proto-Oncogene A-Raf-1 3 4
  • Proto-Oncogene Pks 3 4
  • EC 2.7.11.1 4 61
  • ARAF1 3 4
  • PKS2 3 4
  • V-Raf Murine Sarcoma 3611 Viral Oncogene-Like Protein 3
  • A-Raf Proto-Oncogene Serine/Threonine-Protein Kinase 3
  • Serine/Threonine-Protein Kinase A-Raf 3
  • Ras-Binding Protein DA-Raf 3
  • Proto-Oncogene A-Raf 4
  • Oncogene ARAF1 3
  • EC 2.7.11 61
  • A-RAF 3
  • RAFA1 3
  • PKS 4

External Ids for ARAF Gene

Previous HGNC Symbols for ARAF Gene

  • ARAF1

Previous GeneCards Identifiers for ARAF Gene

  • GC0XP047177
  • GC0XP047305
  • GC0XP047429
  • GC0XP045132

Summaries for ARAF Gene

Entrez Gene Summary for ARAF Gene

  • This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]

CIViC summary for ARAF Gene

  • ARAF has recently become increasingly considered for its oncogenic potential. Its potential as a target for informing clinical action was demonstrated by a single case of advanced lung adenocarcinoma harboring an S214C mutation that, when treated with sorafenib, acheived near-complete clinical remission. This finding has brought new focus on ARAF as a marker that should be assayed for in cancer treatment.

GeneCards Summary for ARAF Gene

ARAF (A-Raf Proto-Oncogene, Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with ARAF include Pallister-Killian Syndrome and Mycobacterium Marinum. Among its related pathways are mTOR Pathway and GPCR Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RAF1.

UniProtKB/Swiss-Prot for ARAF Gene

  • Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade.

  • Isoform 2: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation.

Tocris Summary for ARAF Gene

  • Raf kinases, a family of three serine/threonine kinases, are part of the Ras-MAPK signaling cascade and phosphorylate MEK. Upon growth factor stimulation, Raf-1 (c-Raf) is activated by GTP-bound Ras and recruited to the cell membrane. This activation process is tightly regulated.

Gene Wiki entry for ARAF Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARAF Gene

Genomics for ARAF Gene

Products:

  1. Regulatory Element

Regulatory Elements for ARAF Gene

Enhancers for ARAF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG047128 1.3 Ensembl ENCODE 11 -431.5 -431500 2.0 PKNOX1 ATF1 ARID4B SIN3A FEZF1 DMAP1 BRCA1 ZNF2 YY1 TCF12 LOC100113397 NUS1P1 ARAF ZNF182 ZNF81 INE1 GC0XP047145 LOC105373193
GH0XG047559 1.4 FANTOM5 ENCODE 9.4 +1.3 1330 5.4 HDGF PKNOX1 CREB3L1 ARNT SIN3A DMAP1 ZNF2 YY1 ZNF766 FOS LINC01560 CFP ZNF182 ZNF630 ARAF CDK16 GC0XP047572 GC0XP047571
GH0XG047632 1.6 FANTOM5 Ensembl ENCODE 6.9 +72.8 72827 3.2 HDGF PKNOX1 ZSCAN4 FEZF1 YBX1 RELB IKZF2 EGR2 CEBPB ZEB2 CFP ARAF UXT-AS1 ELK1
GH0XG047555 1.5 FANTOM5 Ensembl ENCODE 5.6 -4.6 -4612 1.7 TBP PKNOX1 KLF17 SIN3A GLIS2 SCRT2 FOS SP3 NFYA SMAD5 ARAF NUS1P1
GH0XG047578 1.3 FANTOM5 Ensembl ENCODE 4.9 +18.4 18386 1.8 TBP ZNF792 MAX ZNF316 FOS MAFK NFE2L2 TCF7L2 ZNF740 CEBPB CFP ARAF TIMP1 GC0XP047573
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARAF on UCSC Golden Path with GeneCards custom track

Promoters for ARAF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000246421 100 2001 HDGF PKNOX1 CREB3L1 ARNT SIN3A DMAP1 ZNF2 YY1 FOS SP3

Transcription factor binding sites by QIAGEN in the ARAF gene promoter:

Genomic Location for ARAF Gene

Chromosome:
X
Start:
47,561,100 bp from pter
End:
47,571,921 bp from pter
Size:
10,822 bases
Orientation:
Plus strand

Genomic View for ARAF Gene

Genes around ARAF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARAF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARAF Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ARAF Gene

Proteins for ARAF Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ARAF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10398-ARAF_HUMAN
    Recommended name:
    Serine/threonine-protein kinase A-Raf
    Protein Accession:
    P10398
    Secondary Accessions:
    • P07557
    • Q5H9B2
    • Q5H9B3

    Protein attributes for ARAF Gene

    Size:
    606 amino acids
    Molecular mass:
    67585 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with TH1L/NELFD.

    Three dimensional structures from OCA and Proteopedia for ARAF Gene

    Alternative splice isoforms for ARAF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARAF Gene

Protein Expression for ARAF Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for ARAF Gene

P10398:
  • GSVLWMA
  • NILLFMG
  • FHQHCSS
  • RDQIIFMVGRGYLSPDLSK
  • NPYSFQSDVYA
  • TVKIGDFGLATVK
  • TQWCEGSSLY
  • RSASEPSL
  • RKTFFSL
  • HNFVRKTF
  • ARQTAQGMDYLHAK
  • ERPLFPQIL
  • LPNKQRTVV
  • WHGDVAVK
  • GFRCQTCGYKFH
  • KSNNIFLH

Post-translational modifications for ARAF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARAF Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ARAF (ARAF)
  • Abcam antibodies for ARAF

Domains & Families for ARAF Gene

Gene Families for ARAF Gene

HGNC:
IUPHAR :

Protein Domains for ARAF Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ARAF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10398

UniProtKB/Swiss-Prot:

ARAF_HUMAN :
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
genes like me logo Genes that share domains with ARAF: view

Function for ARAF Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for ARAF Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade.
UniProtKB/Swiss-Prot Function:
Isoform 2: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation.

Enzyme Numbers (IUBMB) for ARAF Gene

Gene Ontology (GO) - Molecular Function for ARAF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA,TAS 3029685
GO:0004674 protein serine/threonine kinase activity IEA,IDA 19667065
GO:0004709 MAP kinase kinase kinase activity IBA,IEA --
GO:0005057 signal transducer activity, downstream of receptor IEA --
genes like me logo Genes that share ontologies with ARAF: view
genes like me logo Genes that share phenotypes with ARAF: view

Animal Models for ARAF Gene

MGI Knock Outs for ARAF:

Animal Model Products

miRNA for ARAF Gene

miRTarBase miRNAs that target ARAF

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARAF

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARAF Gene

Localization for ARAF Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARAF gene
Compartment Confidence
cytosol 5
mitochondrion 3
nucleus 3
plasma membrane 1
extracellular 1

Gene Ontology (GO) - Cellular Components for ARAF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IBA,IEA --
GO:0005829 cytosol IEA,TAS --
genes like me logo Genes that share ontologies with ARAF: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARAF Gene

Pathways & Interactions for ARAF Gene

SuperPathways for ARAF Gene

PathCards logo More details on SuperPathways for ARAF
SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
NCAM signaling for neurite out-growth
.89
DAP12 interactions
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.56
2 Glioma
Glioma
.47
Non-small cell lung cancer
.47
EGFR tyrosine kinase inhibitor resistance
.42
Melanoma
.41
Prostate cancer
.37
Breast cancer
.36
Signaling Pathways in Glioblastoma
.35
Endocrine resistance
.33
Vemurafenib Pathway, Pharmacodynamics
.31
3 Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
IL-21 Signaling Pathways
.90
IL-7 Signaling Pathways
.90
IL-9 Signaling Pathways
.90
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
.90
IL-15 Signaling Pathways
.88
IL-2 Signaling Pathways
.88
IL-4 Signaling Pathways
.84
Adipokines and Insulin Signaling Pathways
.34
4 IL-2 Pathway
ErbB Family Pathway
.59
ErbB4 Pathway
.59
Prolactin Signaling
.54
ErbB2-ErbB3 Heterodimers
.49
UVC-Induced MAPK Signaling
.44
TREM1 Pathway
.43
IL-4 Pathway
.34
5 GPCR Pathway
Ras Pathway
.73
Pancreatic Adenocarcinoma
.59
Breast Cancer Regulation by Stathmin1
.58
Estrogen Pathway
.55
P2Y Receptor Signaling
.38
genes like me logo Genes that share pathways with ARAF: view

SIGNOR curated interactions for ARAF Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for ARAF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity IEA --
GO:0006464 cellular protein modification process TAS 3029685
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with ARAF: view

Drugs & Compounds for ARAF Gene

Products:

  1. Drug

(29) Drugs for ARAF Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra Target 0
regorafenib Approved Pharma inhibitor Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Sorafenib Approved, Investigational Pharma inhibitors, inhibitor Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 700
XL281 Investigational Pharma inhibitor Kinase Inhibitors 0
LGX818 Pharma Inhibition, inhibitor RAF inhibitor,potent and selective, RAF inhibitor, Kinase Inhibitors, Pan-RAF Inhibitor 0

(26) Additional Compounds for ARAF Gene - From: Novoseek, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
 Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Hexadecanoyl-3-(11-eicosenoyl)-sn-glycerol
  • 1-Palmitoyl-3-eicosenoyl-sn-glycerol
  • DAG(16:0/0:0/20:1)
  • DAG(16:0/0:0/20:1n9)
  • DAG(16:0/0:0/20:1w9)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(5) Tocris Compounds for ARAF Gene

Compound Action Cas Number
AZ 628 Potent Raf kinase inhibitor 878739-06-1
GDC 0879 Potent B-Raf inhibitor 905281-76-7
GW 5074 Potent, selective c-Raf1 kinase inhibitor 220904-83-6
SB 590885 Potent B-Raf inhibitor 405554-55-4
ZM 336372 Potent, selective c-Raf inhibitor 208260-29-1

(5) ApexBio Compounds for ARAF Gene

Compound Action Cas Number
AZ 628 Raf kinases,potent and ATP-competitive 878739-06-1
CEP-32496 BRAF(V600E)inhibitor,highly potent 1188910-76-0
GDC-0879 B-Raf inhibitor,potent and selective 905281-76-7
LGX818 RAF inhibitor,potent and selective 1269440-17-6
TAK-632 Pan-RAF inhibitor,potent and selective 1228591-30-7
genes like me logo Genes that share compounds with ARAF: view

Transcripts for ARAF Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for ARAF Gene

(7) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(323) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARAF Gene

V-raf murine sarcoma 3611 viral oncogene homolog:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARAF

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARAF Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - -
SP9: -

ExUns: 15 ^ 16 ^ 17 ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ARAF Gene

GeneLoc Exon Structure for
ARAF
ECgene alternative splicing isoforms for
ARAF

Expression for ARAF Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARAF Gene

mRNA expression in normal human tissues for ARAF Gene
mRNA expression by BioGPS for ARAF GenemRNA expression by GTEx for ARAF Gene

Protein differential expression in normal tissues from HIPED for ARAF Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARAF Gene



Protein tissue co-expression partners for ARAF Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARAF Gene:

ARAF

SOURCE GeneReport for Unigene cluster for ARAF Gene:

Hs.446641

mRNA Expression by UniProt/SwissProt for ARAF Gene:

P10398-ARAF_HUMAN
Tissue specificity: Predominantly in urogenital tissues.

Evidence on tissue expression from TISSUES for ARAF Gene

  • Kidney(4.5)
  • Liver(4.5)
  • Nervous system(4.2)
  • Muscle(3.1)
  • Intestine(2.8)
  • Lung(2.8)
  • Blood(2.3)
genes like me logo Genes that share expression patterns with ARAF: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARAF Gene

Orthologs for ARAF Gene

This gene was present in the common ancestor of animals.

Orthologs for ARAF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ARAF 35
  • 100 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia ARAF 35 34
  • 93.95 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia ARAF 35 34
  • 92.9 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Araf 34
  • 90.62 (n)
mouse
(Mus musculus)
 Mammalia Araf 35 16 34
  • 90.29 (n)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia ARAF 35
  • 69 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia ARAF 35
  • 68 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia ARAF 35
  • 63 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii araf 35 34
  • 65.62 (n)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta phl 35
  • 35 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea lin-45 35
  • 30 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.10630 35
  • 36 (a)
 OneToMany
Species where no ortholog for ARAF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARAF Gene

ENSEMBL:
Gene Tree for ARAF (if available)
TreeFam:
Gene Tree for ARAF (if available)

Paralogs for ARAF Gene

Paralogs for ARAF Gene

(4) SIMAP similar genes for ARAF Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ARAF Gene

genes like me logo Genes that share paralogs with ARAF: view

Variants for ARAF Gene

Sequence variations from dbSNP and Humsavar for ARAF Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_040376 A colorectal adenocarcinoma sample
rs1000473726 -- 47,563,174(+) ACATC(A/T)GCTGC intron-variant
rs1000930549 -- 47,572,048(+) ACAGG(C/T)GGCAC downstream-variant-500B, utr-variant-3-prime
rs1001882020 -- 47,565,192(+) AGCCA(C/T)GAGGC intron-variant, upstream-variant-2KB
rs1002603457 -- 47,570,626(+) CTCCT(A/G)GAAAC intron-variant

Variation tolerance for ARAF Gene

Residual Variation Intolerance Score: 31.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARAF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARAF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARAF Gene

Disorders for ARAF Gene

MalaCards: The human disease database

(4) MalaCards diseases for ARAF Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pallister-killian syndrome
  • tetrasomy 12p
mycobacterium marinum
  • fish tank granuloma
adenosquamous cell lung carcinoma
  • adenosquamous lung carcinoma
aland island eye disease
  • forsius-eriksson syndrome
- elite association - COSMIC cancer census association via MalaCards
Search ARAF in MalaCards View complete list of genes associated with diseases

Relevant External Links for ARAF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARAF
genes like me logo Genes that share disorders with ARAF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARAF Gene

Publications for ARAF Gene

  1. Identification of TH1 as an interaction partner of A-Raf kinase. (PMID: 11952167) Yin X.L. … Gu J.X. (Mol. Cell. Biochem. 2002) 3 4 22 64
  2. The complete sequence and promoter activity of the human A-raf-1 gene (ARAF1). (PMID: 8020955) Lee J.-E. … Rapp U.R. (Genomics 1994) 3 4 22 64
  3. PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12. (PMID: 22609986) Gan X. … Wu D. (Nat. Cell Biol. 2012) 3 4 64
  4. Heterogeneous nuclear ribonucleoprotein H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription. (PMID: 20145135) Rauch J. … Gires O. (Cancer Res. 2010) 3 22 64
  5. DA-Raf1, a competent intrinsic dominant-negative antagonist of the Ras-ERK pathway, is required for myogenic differentiation. (PMID: 17535970) Yokoyama T. … Endo T. (J. Cell Biol. 2007) 3 4 64

Products for ARAF Gene

  • Addgene plasmids for ARAF

Sources for ARAF Gene

Content
Loading form....