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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AQPEP Gene

protein-coding   GIFtS: 45
GCID: GC05P115298

Laeverin


Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
LVRN2 3 5     EC 3.4.11.-3
AP-Q2 3     Laeverin3
CHL2 Antigen2 3     EC 3.4.118
APQ2     EC 3.4.11.28
Aminopeptidase Q2     EC 3.4.24.578
laeverin2     

External Ids:    Entrez Gene: 2063382   Ensembl: ENSG000001729017   OMIM: 6100465   UniProtKB: Q6Q4G33   

Export aliases for AQPEP gene to outside databases

Previous GC identifer: GC05P110478


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for AQPEP Gene: 
AQPEP is a protein-coding gene. Diseases associated with AQPEP include chronic laryngitis, and hypopharynx cancer. GO annotations related to this gene include metalloendopeptidase activity and zinc ion binding. An important paralog of this gene is LNPEP.

UniProtKB/Swiss-Prot: AMPQ_HUMAN, Q6Q4G3
Function: Metalloprotease which may be important for placentation by regulating biological activity of key
peptides at the embryo-maternal interface. On synthetic substrates it shows a marked preference for
Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met-MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of
several peptides such as angiotensin-3, kisspeptin-10 and endokinin C




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_034772.6  NC_018916.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for AQPEP
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAQPEP promoter sequence
   Search SABiosciences Chromatin IP Primers for AQPEP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AQPEP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.1   Ensembl cytogenetic band:  5q23.1   

AQPEP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AQPEP gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P115298:  view genomic region     (about GC identifiers)

Start:
115,298,151 bp from pter      End:
115,363,316 bp from pter
Size:
65,166 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AMPQ_HUMAN, Q6Q4G3 (See protein sequence)
Recommended Name: Aminopeptidase Q  
Size: 990 amino acids; 113283 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Homodimer
Subcellular location: Membrane; Single-pass type II membrane protein
Sequence caution: Sequence=BAC11422.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8K6J0 C9JGD2 Q32MR1 Q4G0I9 Q4G0V2 Q86XA3 Q8NBZ2
Alternative splicing: 4 isoforms:  Q6Q4G3-1   Q6Q4G3-2   Q6Q4G3-3   Q6Q4G3-4   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for AQPEP: NX_Q6Q4G3

Explore proteomics data for AQPEP at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6Q4G3

  • 4 DME Specific Peptides for AQPEP (Q6Q4G3)
     WLNEGFA  WFGNLVT  KATFNIT  LAVTTTP 

    AQPEP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AQPEP Protein Expression
    REFSEQ proteins: NP_776161.3  
    ENSEMBL proteins: 
     ENSP00000423604   ENSP00000350541   ENSP00000427574   ENSP00000427418   ENSP00000427500  
     ENSP00000378899  

    Human Recombinant Protein Products for AQPEP: 
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    OriGene Protein Over-expression Lysate for AQPEP
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    Novus Biologicals AQPEP Protein
    Novus Biologicals AQPEP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    AQPEP for ontologies           About GeneDecksing



    AQPEP Antibody Products: 
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR001930 Peptidase_M1
     IPR014782 Peptidase_M1_N
     IPR024571 DUF3358

    Graphical View of Domain Structure for InterPro Entry Q6Q4G3

    ProtoNet protein and cluster: Q6Q4G3

    1 Blocks protein domain: IPB001930 Membrane alanyl dipeptidase (M1) family signature

    UniProtKB/Swiss-Prot: AMPQ_HUMAN, Q6Q4G3
    Similarity: Belongs to the peptidase M1 family


    AQPEP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AMPQ_HUMAN, Q6Q4G3
    Function: Metalloprotease which may be important for placentation by regulating biological activity of key
    peptides at the embryo-maternal interface. On synthetic substrates it shows a marked preference for
    Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met-MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of
    several peptides such as angiotensin-3, kisspeptin-10 and endokinin C
    Enzyme regulation: Inhibited by bestatin
    Biophysicochemical properties: Kinetic parameters: KM=78.2 uM for Leu-4-methylcoumaryl-7-amide; pH dependence:
    Optimum pH is 7.0;

         Enzyme Numbers (IUBMB): EC 3.4.11.-1 EC 3.4.24.572 EC 3.4.11.22 EC 3.4.112

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008237metallopeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    AQPEP for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for AQPEP:
     Decreased POU5F1-GFP protein e  Increased gamma-H2AX phosphory  Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for AQPEP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AQPEP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AQPEP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AQPEP 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AQPEP
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate AQPEP (see all 10):
    hsa-miR-642a hsa-miR-137 hsa-miR-374b hsa-miR-548s hsa-miR-374a hsa-miR-3922-3p hsa-miR-9 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidAQPEP 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sino Biological Human cDNA Clone for AQPEP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AQPEP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AQPEP
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                         Customized lentivirus expression plasmids for stable overexpression of AQPEP 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AQPEP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AQPEP

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--

    AQPEP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AQPEP (AMPQ)

    Search CenterWatch for drugs/clinical trials and news about AQPEP / AMPQ

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AQPEP gene: 
    NM_173800.4  

    Unigene Cluster for AQPEP:

    Laeverin
    Hs.98288  [show with all ESTs]
    Unigene Representative Sequence: NM_173800
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504467 ENST00000357872(uc003kro.3 uc003krp.3) ENST00000514509
    ENST00000503329(uc003krq.3 uc003krr.3 uc003krs.3) ENST00000512314
    ENST00000503203 ENST00000515454 ENST00000512413 ENST00000506279 ENST00000395528

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AQPEP
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate AQPEP (see all 10):
    hsa-miR-642a hsa-miR-137 hsa-miR-374b hsa-miR-548s hsa-miR-374a hsa-miR-3922-3p hsa-miR-9 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidAQPEP 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    OriGene ORF clones in mouse, rat for AQPEP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: AQPEP (NM_173800)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for AQPEP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AQPEP
    Sirion Biotech Customized lentivirus for stable overexpression of AQPEP 
                         Customized lentivirus expression plasmids for stable overexpression of AQPEP 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for AQPEP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AQPEP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AQPEP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AQPEP

    Additional mRNA sequence: 

    AK027809.1 AK075131.1 AK092445.1 AK291655.1 AY560010.1 BC060869.1 BC068560.1 BC109022.1 
    BC109023.1 

    8 DOTS entries:

    DT.101956727  DT.99998366  DT.99930335  DT.106803  DT.100737642  DT.92017872  DT.75118046  DT.91995496 

    24/54 AceView cDNA sequences (see all 54):

    AI333894 AA453771 N58022 AK027809 NM_173800 BC070028 BX096521 AI222989 
    AA043040 CR608077 AA418273 BC060869 BG720834 AA042985 BQ717669 AL543134 
    AY560010 BC045809 AI246369 BF438793 AA203555 BG211371 AI146989 AI089453 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for AQPEP (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c
    SP1:                                                                                      -           -                           
    SP2:                                      -                                               -           -                           
    SP3:                                                  -     -                             -           -                           
    SP4:                                      -           -                                   -     -     -                           
    SP5:                                                                                                  -                           



    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AQPEP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    AQPEP Expression
    About this image


    See AQPEP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AQPEP

    SOURCE GeneReport for Unigene cluster: Hs.98288

    UniProtKB/Swiss-Prot: AMPQ_HUMAN, Q6Q4G3
    Tissue specificity: Specifically expressed in placenta and not in other tissues. Mainly found at the cell surface
    region of the extravillous trophoblasts. Detected on extravillous trophoblasts in the outer layer of the chorion
    laeve in the fetal membrane Not detected on either fetal amnionic epithelial cells or maternal decidual cells.
    Also detected in the migrating extravillous trophoblasts in the maternal decidual tissues (at protein level)

        SABiosciences Custom PCR Arrays for AQPEP
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AQPEP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AQPEP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for AQPEP gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 4833403I15Rik1 , 5 RIKEN cDNA 4833403I15 gene1, 5 76.47(n)1
    67.65(a)1
      18 (24.84 cM)5
    745741  NM_029008.11  NP_083284.11 
     468500395 
    chicken
    (Gallus gallus)
    Aves LOC4316491 aminopeptidase Q-like 63.22(n)
    53.18(a)
      431649  XM_429201.3  XP_429201.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    44(a)
    1 ↔ 1
    GL343193.1(8444200-8487754)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG404706
    CG44676
    --
    20(a)
    18(a)
    many ↔ many
    many ↔ many
    3L(23832960-23979510)
    3R(19053439-19074623)
    worm
    (Caenorhabditis elegans)
    Secernentea T12E12.66
    Y42A5A.16
    (see all 5)
    Protein Y42A5A.1
    (see all 5)
    22(a)
    20(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    IV(5567052-5574109)
    V(11088154-11097978)


    ENSEMBL Gene Tree for AQPEP (if available)
    TreeFam Gene Tree for AQPEP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AQPEP gene
    LNPEP2  ENPEP2  ANPEP2  TRHDE2  ERAP12  NPEPPS2  ERAP22  
    8 SIMAP similar genes for AQPEP using alignment to 1 protein entry:     AMPQ_HUMAN:
    FLJ90650    CD13    TRHDE    ANPEP    ERAP1    NPEPPSL1
    ENPEP    LNPEP

    AQPEP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1976 SNPs in AQPEP are shown (see all 1976)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2003163161,2
    --115296201(+) ATCAG-/AAATAT 1 -- us2k10--------
    rs1870718111,2
    --115296328(+) AAATGC/TTAGTG 1 -- us2k10--------
    rs773099031,2
    --115296336(+) GTGTCC/TATATA 1 -- us2k10--------
    rs1498071131,2
    --115296442(+) TCCTTC/TGAAAT 1 -- us2k10--------
    rs1456966241,2
    --115296443(+) CCTTCA/GAAATC 1 -- us2k10--------
    rs1928517701,2
    --115296467(+) CCCACA/GGGTTG 1 -- us2k10--------
    rs77041281,2
    C,F,H--115296567(+) AGCTCA/CAATTC 1 -- us2k111Minor allele frequency- C:0.04NS EA NA CSA WA 1290
    rs1851731271,2
    --115296583(+) GCACAA/GCTTGT 1 -- us2k10--------
    rs1399172931,2
    --115296590(+) TTGTGC/GTAGGT 1 -- us2k10--------
    rs1456492641,2
    --115296597(+) AGGTAC/TATGGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for AQPEP (115298151 - 115363316 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for AQPEP:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2730630CNV Deletion23290073
    esv34146CNV Loss18971310
    nsv882738CNV Loss21882294
    nsv882735CNV Gain21882294
    dgv6297n71CNV Gain21882294
    nsv515611CNV Gain+Loss19592680
    esv7796OTHER Inversion19470904

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610046    OMIM disorders: --

    10 diseases for AQPEP:    About MalaCards
    chronic laryngitis    hypopharynx cancer    hemiplegia    chronic fatigue syndrome
    cerebral palsy    laryngitis    cerebritis    pneumonia
    rheumatoid arthritis    arthritis

    2 diseases from the University of Copenhagen DISEASES database for AQPEP:
    Chronic fatigue syndrome     Laryngitis

    AQPEP for disorders           About GeneDecksing

    Genetic Association Database (GAD): AQPEP
    Human Genome Epidemiology (HuGE) Navigator: AQPEP (0 documents)

    Export disorders for AQPEP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AQPEP gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with AQPEP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human extravillous trophoblasts express laeverin, a novel protein that belongs to membrane-bound gluzincin metallopeptidases. (PubMed id 14706636)1, 2, 9 Fujiwara H.... Fujii S. (2004)
    2. The ERAP2 gene is associated with preeclampsia in Aus tralian and Norwegian populations. (PubMed id 19578876)1, 4 Johnson M.P....Moses E.K. (2009)
    3. Laeverin/aminopeptidase Q, a novel bestatin-sensitive leucine aminopeptidase belonging to the M1 family of aminopeptidases. (PubMed id 17525158)1, 2 Maruyama M....Tsujimoto M. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Histidine 379 of human laeverin/aminopeptidase Q, a n onconserved residue within the exopeptidase motif, defines its distinctive enzy matic properties. (PubMed id 19819873)1, 9 Maruyama M....Tsujimoto M. (2009)
    7. Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twins. (PubMed id 16804865)1, 9 Haas C.S....Holoshitz J. (2006)
    8. Regulation of human extravillous trophoblast function by membrane-bound peptidases. (PubMed id 15897020)1, 9 Fujiwara H....Maeda M. (2005)
    9. Laeverin/aminopeptidase Q induces trophoblast invasion during human early placentation. (PubMed id 22402206)1 Horie A....Hattori A. (2012)
    10. Involvement of glutamine-238 in the substrate specifi city of human laeverin/aminopeptidase Q. (PubMed id 21212512)1 Goto Y....Tsujimoto M. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 206338 AceView: FLJ90650 Ensembl:ENSG00000172901 euGenes: HUgn206338

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AQPEP gene:
    Search GeneIP for patents involving AQPEP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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