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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AQPEP Gene

protein-coding   GIFtS: 41
GCID: GC05P115298

AQPEP
 Explore 10 diseases affiliated with
AQPEP via
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 Human Malady Compendium 
Biological research products
for AQPEP    

Aliases
for AQPEP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
LVRN2 3 5     EC 3.4.11.-3
AP-Q2 3     Laeverin3
CHL2 Antigen2 3     EC 3.4.118
APQ2     EC 3.4.11.28
Aminopeptidase Q2     EC 3.4.24.578
Laeverin3     

External Ids:    Entrez Gene: 2063382   Ensembl: ENSG000001729017   OMIM: 6100465   UniProtKB: Q6Q4G33   

Export aliases for AQPEP gene to outside databases

Previous GC identifer: GC05P110478


Summaries
for AQPEP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: AMPQ_HUMAN, Q6Q4G3
Function: Metalloprotease which may be important for placentation by regulating biological activity of key peptides at
the embryo-maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide
(Leu-MCA) over Met-MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of several peptides such as
angiotensin-3, kisspeptin-10 and endokinin C




Genomic Views
for AQPEP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_034772.6  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for AQPEP
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AQPEP promoter sequence
   Search SABiosciences Chromatin IP Primers for AQPEP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AQPEP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.1   Ensembl cytogenetic band:  5q23.1   

AQPEP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AQPEP gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P115298:  view genomic region     (about GC identifiers)

Start:
 115,298,151 bp from pter      End:
 115,394,680 bp from pter
Size:
 96,530 bases      Orientation:
 plus strand

Proteins
for AQPEP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AMPQ_HUMAN, Q6Q4G3 (See protein sequence)
Recommended Name: Aminopeptidase Q  
Size: 990 amino acids; 113283 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Homodimer
Subcellular location: Membrane; Single-pass type II membrane protein
Sequence caution: Sequence=BAC11422.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8K6J0 C9JGD2 Q32MR1 Q4G0I9 Q4G0V2 Q86XA3 Q8NBZ2
Alternative splicing: 4 isoforms:  Q6Q4G3-1   Q6Q4G3-2   Q6Q4G3-3   Q6Q4G3-4   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for AQPEP: NX_Q6Q4G3

Post-translational modifications:

  • N-glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6Q4G3

    • 4 DME Specific Peptides for AQPEP (Q6Q4G3)
     WLNEGFA  WFGNLVT  KATFNIT  LAVTTTP 

    AQPEP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_776161.3  
    ENSEMBL proteins: 
     ENSP00000423604   ENSP00000350541   ENSP00000427574   ENSP00000427418   ENSP00000427500  
     ENSP00000424374   ENSP00000456703   ENSP00000378899  

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    OriGene Protein Over-expression Lysate: AQPEP
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    Novus Biologicals AQPEP Protein
    Novus Biologicals AQPEP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    AQPEP for ontologies           About GeneDecksing



    AQPEP Antibody Products: 
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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for AQPEP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    AQPEP for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001930 Peptidase_M1
     IPR014782 Peptidase_M1_N
     IPR024571 DUF3358

    Graphical View of Domain Structure for InterPro Entry Q6Q4G3

    ProtoNet protein and cluster: Q6Q4G3

    1 Blocks protein family: IPB001930 Membrane alanyl dipeptidase (M1) family signature

    UniProtKB/Swiss-Prot: AMPQ_HUMAN, Q6Q4G3
    Similarity: Belongs to the peptidase M1 family


    Function
    for AQPEP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AMPQ_HUMAN, Q6Q4G3
    Function: Metalloprotease which may be important for placentation by regulating biological activity of key peptides at
    the embryo-maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide
    (Leu-MCA) over Met-MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of several peptides such as
    angiotensin-3, kisspeptin-10 and endokinin C
    Enzyme regulation: Inhibited by bestatin
    Biophysicochemical properties: Kinetic parameters: KM=78.2 uM for Leu-4-methylcoumaryl-7-amide; pH dependence: Optimum
    pH is 7.0;

    Enzyme Numbers (IUBMB): EC 3.4.11.-1 EC 3.4.24.572 EC 3.4.11.22 EC 3.4.112

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AQPEP
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate AQPEP (see all 10):
    hsa-miR-642a hsa-miR-137 hsa-miR-374b hsa-miR-548s hsa-miR-374a hsa-miR-3922-3p hsa-miR-9 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmid: AQPEP 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AQPEP
    OriGene shRNA RFP: AQPEP
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AQPEP

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AQPEP (see all 2)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AQPEP 

    Cell Line
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    Search LifeMap BioReagents cell lines for AQPEP

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0008237metallopeptidase activity ----
    GO:0008270zinc ion binding IEA--


    AQPEP for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for AQPEP:
     Decreased POU5F1-GFP protein e  Increased gamma-H2AX phosphory  Increased homologous recombina 


    Pathways & Interactions
    for AQPEP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AQPEP

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--


    AQPEP for ontologies           About GeneDecksing



    Drugs & Compounds
    for AQPEP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AQPEP
    Search CenterWatch for drugs/clinical trials and news about AQPEP / AMPQ 

    Transcripts
    for AQPEP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for AQPEP gene: 
    NM_173800.4  

    Unigene Cluster for AQPEP:

    Laeverin
    Hs.98288  [show with all ESTs]
    Unigene Representative Sequence: NM_173800
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504467 ENST00000357872(uc003kro.3 uc003krp.3) ENST00000514509
    ENST00000503329(uc003krq.3 uc003krr.3 uc003krs.3) ENST00000512314
    ENST00000503203 ENST00000515454 ENST00000512413 ENST00000506279 ENST00000504222(uc021yct.1)
    ENST00000395528

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AQPEP
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate AQPEP (see all 10):
    hsa-miR-642a hsa-miR-137 hsa-miR-374b hsa-miR-548s hsa-miR-374a hsa-miR-3922-3p hsa-miR-9 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmid: AQPEP 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AQPEP
    OriGene shRNA RFP: AQPEP
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AQPEP
    Clone
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    GenScript: all cDNA clones in your preferred vector: AQPEP (NM_173800)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AQPEP 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AQPEP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AQPEP

    Additional cDNA sequence: 

    AK027809.1 AK075131.1 AK092445.1 AK291655.1 AY560010.1 BC060869.1 BC068560.1 BC109022.1 
    BC109023.1 

    8 DOTS entries:

    DT.101956727  DT.99998366  DT.99930335  DT.106803  DT.100737642  DT.92017872  DT.75118046  DT.91995496 

    24/54 AceView cDNA sequences (see all 54):

    BC070028 AK027809 AA453771 NM_173800 AA418273 BX096521 AI333894 N58022 
    CR608077 AI222989 AA043040 BC060869 AA042985 BF438793 BG720834 AA883856 
    AI246369 AY560010 AA453854 BG211371 AI089327 BI829157 BQ717669 AL543134 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for AQPEP (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b · 15c
    SP1:                                                                                      -           -                           
    SP2:                                      -                                               -           -                           
    SP3:                                                  -     -                             -           -                           
    SP4:                                      -           -                                   -     -     -                           
    SP5:                                                                                                  -                           



    Expression
    for AQPEP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AQPEP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See AQPEP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AQPEP

    SOURCE GeneReport for Unigene cluster: Hs.98288

    UniProtKB/Swiss-Prot: AMPQ_HUMAN, Q6Q4G3
    Tissue specificity: Specifically expressed in placenta and not in other tissues. Mainly found at the cell surface
    region of the extravillous trophoblasts. Detected on extravillous trophoblasts in the outer layer of the chorion laeve
    in the fetal membrane Not detected on either fetal amnionic epithelial cells or maternal decidual cells. Also detected
    in the migrating extravillous trophoblasts in the maternal decidual tissues (at protein level)

        SABiosciences Custom PCR Arrays for AQPEP
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    In Situ
    Assay Products:     
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    Orthologs
    for AQPEP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for AQPEP gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia 4833403I15Rik1 , 5 RIKEN cDNA 4833403I15 gene1, 5 76.47(n)1
    67.65(a)1    		   18 (24.84 cM)5
    745741  NM_029008.11  NP_083284.11 
     468500395 
    chicken
    (Gallus gallus)    		 Aves LOC4316491 aminopeptidase Q-like 63.22(n)
    53.18(a)    		   431649  XM_429201.3  XP_429201.3 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 44(a)
    		 1 ↔ 1
    		 GL343193.1(8444200-8487754)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG312336
    CG313436
    (see all 7)    		 --
    		 23(a)
    23(a)
    (see all 7)    		 many → 1
    many → 1
    (see all 7)    		 3R(17575575-17578959)
    3R(17570991-17574725)
    worm
    (Caenorhabditis elegans)    		 Secernentea T07F10.16
    AC3.56
    		 Aminopeptidase-like protein AC3.5
    		 21(a)
    17(a)
    		 possible ortholog
    1 ↔ 1
    		 V(12859364-12863816)
    V(10388447-10393480)


    ENSEMBL Gene Tree for AQPEP (if available)
    TreeFam Gene Tree for AQPEP (if available) 

    Paralogs
    for AQPEP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AQPEP gene
    LNPEP2  ENPEP2  ANPEP2  TRHDE2  ERAP12  NPEPPS2  ENSG000001740932  ERAP22  
    11 SIMAP similar genes for AQPEP using alignment to 2 protein entries:     AMPQ_HUMAN (see all proteins):
    ARL14EPL    FLJ90650    CD13    ARL14EP    TRHDE    ANPEP
    ERAP1    NPEPPSL1    ENPEP    LNPEP    ERAP2

    AQPEP for paralogs           About GeneDecksing



    Genomic Variants
    for AQPEP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1682 NCBI SNPs in AQPEP are shown (see all 1682)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs718358181,2
    		C--110511069(+) CATATTTAA/-  
                TTAAT     		1 -- int11Minor allele frequency- -:0.50CSA 2
    rs2003163161,2
    		--115296201(+) ATCAG-/AAATAT 1 -- us2k10--------
    rs1870718111,2
    		--115296328(+) AAATGC/TTAGTG 1 -- us2k10--------
    rs773099031,2
    		--115296336(+) GTGTCC/TATATA 1 -- us2k10--------
    rs1498071131,2
    		--115296442(+) TCCTTC/TGAAAT 1 -- us2k10--------
    rs1456966241,2
    		--115296443(+) CCTTCA/GAAATC 1 -- us2k10--------
    rs1928517701,2
    		--115296467(+) CCCACA/GGGTTG 1 -- us2k10--------
    rs77041281,2
    		C,F,H,--115296567(+) AGCTCA/CAATTC 1 -- us2k111Minor allele frequency- C:0.04NS EA NA CSA WA 1290
    rs1851731271,2
    		--115296583(+) GCACAA/GCTTGT 1 -- us2k10--------
    rs1399172931,2
    		--115296590(+) TTGTGC/GTAGGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for AQPEP (115298151 - 115394680 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for AQPEP: --

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    Disorders / Diseases
    for AQPEP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    AQPEP for disorders           About GeneDecksing

    OMIM gene information: 610046    OMIM disorders: --

    10 diseases for AQPEP:    About MalaCards
    hypopharynx cancer    chronic fatigue syndrome    hemiplegia    cerebral palsy
    chronic laryngitis    laryngitis    rheumatoid arthritis    twinning
    cerebritis    arthritis

    2 diseases from the University of Copenhagen DISEASES database for AQPEP:
    Chronic fatigue syndrome     Laryngitis
    Human Genome Epidemiology (HuGE) Navigator: AQPEP (0 documents)

    Export disorders for AQPEP gene to outside databases

    Publications
    for AQPEP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AQPEP gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with AQPEP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human extravillous trophoblasts express laeverin, a novel protein that belongs to membrane-bound gluzincin metallopeptidases. (PubMed id 14706636)1, 2, 9 Fujiwara H.... Fujii S. (2004)
    2. Laeverin/aminopeptidase Q, a novel bestatin-sensitive leucine aminopeptidase belonging to the M1 family of aminopeptidases. (PubMed id 17525158)1, 2 Maruyama M....Tsujimoto M. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Histidine 379 of human laeverin/aminopeptidase Q, a n onconserved residue within the exopeptidase motif, defines its distinctive enzy matic properties. (PubMed id 19819873)1, 9 Maruyama M....Tsujimoto M. (2009)
    6. Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twins. (PubMed id 16804865)1, 9 Haas C.S....Holoshitz J. (2006)
    7. Regulation of human extravillous trophoblast function by membrane-bound peptidases. (PubMed id 15897020)1, 9 Fujiwara H....Maeda M. (2005)
    8. Laeverin/aminopeptidase Q induces trophoblast invasion during human early placentation. (PubMed id 22402206)1 Horie A....Hattori A. (2012)
    9. Involvement of glutamine-238 in the substrate specifi city of human laeverin/aminopeptidase Q. (PubMed id 21212512)1 Goto Y....Tsujimoto M. (2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    External Searches for AQPEP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing AQPEP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 206338 AceView: FLJ90650 Ensembl:ENSG00000172901 euGenes: HUgn206338

    Other Databases showing AQPEP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing AQPEP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    		   --

    Intellectual Property
    for AQPEP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for AQPEP gene:
    Search GeneIP for patents involving AQPEP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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