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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AQP9 Gene

protein-coding   GIFtS: 56
GCID: GC15P058430

aquaporin 9
 Explore 30 diseases affiliated with
AQP9 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for AQP9    

Aliases
for AQP9 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Aquaporin 91 2     AQP-92 3
SSC11 2 3     Aquaglyceroporin-93
HsT172871 2     Aquaporin-91
Small Solute Channel 12 3     Aquaglyceroporin-93

External Ids:    HGNC: 6431   Entrez Gene: 3662   Ensembl: ENSG000001035697   OMIM: 6029145   UniProtKB: O433153   

Export aliases for AQP9 gene to outside databases

Previous GC identifers: GC15P053987 GC15P051477 GC15P056009 GC15P056146 GC15P056217 GC15P035253


Summaries
for AQP9 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for AQP9:
The aquaporins are a family of water-selective membrane channels. The protein encoded by this gene allows passage of a
wide variety of noncharged solutes. It stimulates urea transport and osmotic water permeability; there are
contradicting reports about its role in providing glycerol permeability. The encoded protein may also play a role in
specialized leukocyte functions such as immunological response and bactericidal activity. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: AQP9_HUMAN, O43315
Function: Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including
carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids,
cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol

Gene Wiki entry for AQP9


Genomic Views
for AQP9 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AQP9 gene promoter:
         SRF   Pbx1a   AML1a   RREB-1   SRF (504 AA)   FOXD1   Evi-1   GATA-1   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AQP9 promoter sequence
   Search SABiosciences Chromatin IP Primers for AQP9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AQP9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q   Ensembl cytogenetic band:  15q21.3   HGNC cytogenetic band: 15q

AQP9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AQP9 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P058430:  view genomic region     (about GC identifiers)

Start:
 58,430,368 bp from pter      End:
 58,478,110 bp from pter
Size:
 47,743 bases      Orientation:
 plus strand

Proteins
for AQP9 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AQP9_HUMAN, O43315 (See protein sequence)
Recommended Name: Aquaporin-9  
Size: 295 amino acids; 31431 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q9NP32

Explore the universe of human proteins at neXtProt for AQP9: NX_O43315

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43315

    • AQP9 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_066190.2  
    ENSEMBL proteins: 
     ENSP00000452673   ENSP00000219919   ENSP00000441390  
    Reactome Protein details: O43315
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate: AQP9
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    Novus Biologicals AQP9 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for AQP9

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005792microsome ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS9514918
    GO:0016021integral to membrane NAS9733774
    GO:0016323basolateral plasma membrane IEA--


    AQP9 for ontologies           About GeneDecksing



    AQP9 Antibody Products: 
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    Uscn ELISAs and CLIAs for AQP9

    Protein Domains /
    Families
    for AQP9 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    AQP9 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR022357 MIP_CS
     IPR015685 Aquaporin_9
     IPR023271 Aquaporin-like
     IPR000425 MIP

    Graphical View of Domain Structure for InterPro Entry O43315

    ProtoNet protein and cluster: O43315

    1 Blocks protein family: IPB000425 MIP family

    UniProtKB/Swiss-Prot: AQP9_HUMAN, O43315
    Domain: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop
    with the signature motif Asn-Pro-Ala (NPA)
    Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family


    Function
    for AQP9 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AQP9_HUMAN, O43315
    Function: Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including
    carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids,
    cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol

    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate AQP9 (see all 17):
    hsa-miR-607 hsa-miR-522 hsa-miR-485-3p hsa-miR-16-1* hsa-miR-885-5p hsa-miR-3171 hsa-miR-3119 hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmid: AQP9 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AQP9 (see all 7)
    OriGene shRNA RFP: AQP9
    OriGene siRNA: AQP9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AQP9

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for AQP9

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AQP9 (see all 4)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AQP9 

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    Search LifeMap BioReagents cell lines for AQP9

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AQP9

    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005275amine transmembrane transporter activity TAS9733774
    GO:0005345purine nucleobase transmembrane transporter activity IDA9733774
    GO:0005350pyrimidine nucleobase transmembrane transporter activity IDA9733774
    GO:0005372water transmembrane transporter activity TAS9733774
    GO:0015166polyol transmembrane transporter activity TAS9733774


    AQP9 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for AQP9:
     Increased S DNA content 

    Animal Models:
         Mouse knock-out Aqp9tm1Nlsn for AQP9
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Aqp9):
     hematopoietic system  homeostasis/metabolism  immune system 

    AQP9 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for AQP9 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Passive Transport by Aquaporins
    		Passive Transport by Aquaporins1.00
    2Transport of Glycerol from Adipocytes to the Liver by Aquaporins
    		Transport of Glycerol from Adipocytes to the Liver by Aquaporins1.00
    3Selected targets of GCR-alpha
    		Selected targets of GCR-alpha1.00
    4Bile secretion
    		Bile secretion1.00
    5Regulation of Water Balance by Renal Aquaporins
    		Aquaporin-mediated transport0.84

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for AQP9
        Selected targets of GCR-alpha

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for AQP9
        eNOS Signaling

    4        Reactome Pathways for AQP9
        Transmembrane transport of small molecules
    Aquaporin-mediated transport
    Transport of Glycerol from Adipocytes to the Liver by Aquaporins
    Passive Transport by Aquaporins


    1         Kegg Pathway  (Kegg details for AQP9):
        Bile secretion


    AQP9 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AQP9

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS9733774
    GO:0006833water transport TAS--
    GO:0006863purine nucleobase transport IDA9733774
    GO:0006955immune response TAS9514918
    GO:0006970response to osmotic stress TAS9733774


    AQP9 for ontologies           About GeneDecksing



    Drugs & Compounds
    for AQP9 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AQP9 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AQP9
    6 Novoseek chemical compound relationships for AQP9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycerol 66.9 21 18762715 (2), 18055461 (2), 9514918 (2), 17636116 (1) (see all 10)
    urea 37.7 8 16480766 (3), 9514918 (2), 11597198 (1), 19916714 (1)
    mercury 25.6 2 15561410 (1), 16480766 (1)
    mannitol 15.9 3 16480766 (2)
    lactate 13.1 8 15561412 (3), 16126913 (1), 19916714 (1), 17701333 (1)
    glucose 5.18 1 15561412 (1)

    Search CenterWatch for drugs/clinical trials and news about AQP9 

    Transcripts
    for AQP9 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for AQP9 gene: 
    NM_020980.3  

    Unigene Cluster for AQP9:

    Aquaporin 9
    Hs.104624  [show with all ESTs]
    Unigene Representative Sequence: NM_020980
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000558772 ENST00000219919(uc010ugx.1 uc002aez.2) ENST00000559443
    ENST00000536493

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AQP9
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate AQP9 (see all 17):
    hsa-miR-607 hsa-miR-522 hsa-miR-485-3p hsa-miR-16-1* hsa-miR-885-5p hsa-miR-3171 hsa-miR-3119 hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmid: AQP9 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AQP9 (see all 7)
    OriGene shRNA RFP: AQP9
    OriGene siRNA: AQP9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AQP9
    Clone
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    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AQP9
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AQP9
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AQP9
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AQP9

    Additional cDNA sequence: 

    AB008775.1 AF016495.1 AK300055.1 AK313214.1 BC026258.1 CR542027.1 

    3 DOTS entries:

    DT.410734  DT.100755062  DT.95189072 

    24/52 AceView cDNA sequences (see all 52):

    CB268474 AV658659 CB154156 AI693953 BU621112 AV656458 AA381471 AI360746 
    NM_020980 BG617142 AA381158 CB528930 BG236266 CB162263 AW613564 AW129914 
    CD638629 AW014829 BM993104 BG618439 AI719611 CB164058 CA309204 CR542027 

    GeneLoc Exon Structure


    Expression
    for AQP9 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AQP9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCTAGAAGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    AQP9 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobulePerivenous HepatocytesLiver
    Umbilical CordUmbilical VeinsUmbilical Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See AQP9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AQP9

    SOURCE GeneReport for Unigene cluster: Hs.104624

    UniProtKB/Swiss-Prot: AQP9_HUMAN, O43315
    Tissue specificity: Highly expressed in peripheral leukocytes. Also expressed in liver, lung, and spleen

        SABiosciences Expression via Pathway-Focused PCR Arrays including AQP9: 
              Drug Transporters in human mouse rat
              Osmotic Stress in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AQP9

    Orthologs
    for AQP9 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for AQP9 gene from 8/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Aqp91 , 5 aquaporin 91, 5 78.76(n)1
    75.59(a)1    		   9 (39.85 cM)5
    640081  NM_022026.21  NP_071309.11 
     711106595 
    chicken
    (Gallus gallus)    		 Aves AQP91 aquaporin 9 68.58(n)
    65.59(a)    		   415402  XM_001233181.2  XP_001233182.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii aqp9a1 aquaporin 9a 57.07(n)
    55.04(a)    		   606660  NM_001033096.1  NP_001028268.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea C01G6.1b3
    aqp-21    		 Major intrinsic protein3
    Protein AQP-21    		 42(a)
    (best of 4)3
    53.54(n)1
    43.18(a)1    		   II(9259518-9261883)3
    1744671  NM_063571.31  NP_495972.11 
    A. gossypii yeast
    (Ashbya gossypii)    		 Saccharomycetes AGOS_ACL068W1 ACL068Wp 44.4(n)
    34(a)    		   4619456  NM_208689.1  NP_983336.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons NIP7;11 putative aquaporin NIP7-1 47.69(n)
    38.89(a)    		   819783  NM_111485.2  NP_566271.1 
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 12)    		 aquaporin protein, putative, expressed
    (see all 12)    		 23(a)
    22(a)
    (see all 12)    		 possible ortholog
    possible ortholog
    (see all 12)    		 2(7515989-7519336)
    5(6539758-6544751)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria glpF6
    		 glycerol facilitator
    		 37(a)
    		 possible ortholog
    		 Chromosome(4115268-4116113)


    ENSEMBL Gene Tree for AQP9 (if available)
    TreeFam Gene Tree for AQP9 (if available) 

    Paralogs
    for AQP9 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AQP9 gene
    AQP102  AQP32  AQP72  
    5 SIMAP similar genes for AQP9 using alignment to 3 protein entries:     AQP9_HUMAN (see all proteins):
    AQP3    AQP10    AQP7    bA251O17.3    AQP7P3

    AQP9 for paralogs           About GeneDecksing



    Genomic Variants
    for AQP9 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1114 NCBI SNPs in AQP9 are shown (see all 1114)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs571392081,2
    		F,--35251709(+) GTCCCC/TTACCC 1 -- us2k13Minor allele frequency- T:0.05WA NA EA 358
    rs740189541,2
    		C,--35252088(+) GAGAAC/TGCTCT 1 -- us2k12Minor allele frequency- T:0.03WA 120
    rs116298011,2
    		C,H--35252397(+) CAAAGC/TTAGGG 1 -- us2k14Minor allele frequency- T:0.00NS EA 414
    rs99208531,2
    		C,F,H,--35253259(+) TTGACA/G/TGTTCC 1 -- us2k19NS EA NA WA 914
    rs37429551,2
    		C,--35253278(+) CCCCAA/GCCACC 1 -- us2k10--------
    rs124407841,2
    		C,F,H,--35253923(+) TGTTTG/TGTTTG 1 -- int15Minor allele frequency- T:0.09NA EA 246
    rs747184241,2
    		--35254127(+) AAAATA/GGCTTT 1 -- int10--------
    rs286547581,2
    		C,--35254311(+) TTGACA/TAGTAT 1 -- int12Minor allele frequency- T:0.03WA 120
    rs560194181,2
    		C,F,--35254494(+) ATAAAC/TGAGGG 1 -- int11Minor allele frequency- T:0.03NA 120
    rs285374681,2
    		C,--35254502(+) GGGACG/CACTTC 1 -- int11Minor allele frequency- C:0.50WA 2

    HapMap Linkage Disequilibrium report for AQP9 (58430368 - 58478110 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for AQP9: --
    Locus Specific Mutation Databases (LSDB): AQP9

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AQP9
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    Disorders / Diseases
    for AQP9 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    AQP9 for disorders           About GeneDecksing

    OMIM gene information: 602914    OMIM disorders: --

    20/30 diseases for AQP9 (see all 30):    About MalaCards
    glycerol release during exercise, defective    bullous keratopathy    hydrarthrosis    polycystic ovary syndrome
    keratopathy    infective endocarditis    brain edema    morbid obesity
    polyhydramnios    endocarditis    insulin resistance    chorioamnionitis
    cystic fibrosis    hyperandrogenism    constipation    epididymitis
    conjunctivitis    obesity    fibrosis    hepatocellular carcinoma

    2 diseases from the University of Copenhagen DISEASES database for AQP9:
    Hydrarthrosis     Polyhydramnios

    1 Novoseek disease relationship for AQP9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    edema 13.7 2 20126625 (1)

    Human Genome Epidemiology (HuGE) Navigator: AQP9 (4 documents)

    Export disorders for AQP9 gene to outside databases

    Publications
    for AQP9 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AQP9 gene, integrated from 9 sources (see all 76):
    (articles sorted by number of sources associating them with AQP9)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol. (PubMed id 9514918)1, 2, 9 Ishibashi K.... Sasaki S. (1998)
    2. Functional and molecular characterization of the human neutral solute channel aquaporin-9. (PubMed id 10564231)1, 2, 9 Tsukaguchi H.... Hediger M.A. (1999)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Expression of aquaporin 9 in human chorioamniotic membranes and placenta. (PubMed id 15592307)1, 9 Wang S....Ross M.G. (2004)
    5. High levels of human chorionic gonadotropin (hCG) cor relate with increased aquaporin-9 (AQP9) expression in explants from human pree clamptic placenta. (PubMed id 20220109)1, 9 Marino G.I....Damiano A.E. (2010)
    6. Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in g ranulosa cells through the phosphatidylinositol 3-kinase pathway. (PubMed id 20378617)1, 9 Qu F....Huang H.F. (2010)
    7. Fetal membranes as an interface between inflammation and metabolism: increased aquaporin 9 expression in the presence of spontaneous labor at term and chorioamnionitis. (PubMed id 19916714)1, 9 Mittal P....Hassan S.S. (2009)
    8. Aquaporin 9 expression and its localization in normal skeletal myofiber. (PubMed id 19629726)1, 9 Inoue M....Matsuzaki Y. (2009)
    9. Filopodia are induced by aquaporin-9 expression. (PubMed id 17346701)1, 9 Loitto V.M....Jacobson K. (2007)
    10. Functional and molecular expression of AQP9 channel and UT-A transporter in normal and preeclamptic human placentas. (PubMed id 16480766)1, 9 Damiano A.E....Ibarra C. (2006)

    External Searches for AQP9 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing AQP9 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 366 HGNC: 643 AceView: AQP9 Ensembl:ENSG00000103569 euGenes: HUgn366
    ECgene: AQP9 Kegg: 366 H-InvDB: AQP9

    Other Databases showing AQP9 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing AQP9 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AQP9 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for AQP9 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for AQP9 gene:
    Search GeneIP for patents involving AQP9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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