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AQP9 Gene

protein-coding   GIFtS: 60
GCID: GC15P058430

Aquaporin 9

  See AQP9-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Aquaporin 91 2     HsT172872
Small Solute Channel 12 3     aquaglyceroporin-92
AQP-92 3     aquaporin-92
SSC12 3     Aquaglyceroporin-93

External Ids:    HGNC: 6431   Entrez Gene: 3662   Ensembl: ENSG000001035697   OMIM: 6029145   UniProtKB: O433153   

Export aliases for AQP9 gene to outside databases

Previous GC identifers: GC15P053987 GC15P051477 GC15P056009 GC15P056146 GC15P056217 GC15P035253


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AQP9 Gene:
The aquaporins are a family of water-selective membrane channels. The protein encoded by this gene allows passage
of a wide variety of noncharged solutes. It stimulates urea transport and osmotic water permeability; there are
contradicting reports about its role in providing glycerol permeability. The encoded protein may also play a role
in specialized leukocyte functions such as immunological response and bactericidal activity. (provided by RefSeq,
Jul 2008)

GeneCards Summary for AQP9 Gene:
AQP9 (aquaporin 9) is a protein-coding gene. Diseases associated with AQP9 include hydrarthrosis, and polyhydramnios. GO annotations related to this gene include water channel activity and water transmembrane transporter activity. An important paralog of this gene is AQP10.

UniProtKB/Swiss-Prot: AQP9_HUMAN, O43315
Function: Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes
including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas
amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to
urea and glycerol

Gene Wiki entry for AQP9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the AQP9 gene promoter:
         SRF   Pbx1a   AML1a   RREB-1   SRF (504 AA)   FOXD1   Evi-1   GATA-1   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAQP9 promoter sequence
   Search Chromatin IP Primers for AQP9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AQP9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q   Ensembl cytogenetic band:  15q21.3   HGNC cytogenetic band: 15q

AQP9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AQP9 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P058430:  view genomic region     (about GC identifiers)

Start:
58,430,368 bp from pter      End:
58,478,110 bp from pter
Size:
47,743 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AQP9_HUMAN, O43315 (See protein sequence)
Recommended Name: Aquaporin-9  
Size: 295 amino acids; 31431 Da
Secondary accessions: Q9NP32

Explore the universe of human proteins at neXtProt for AQP9: NX_O43315

Explore proteomics data for AQP9 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AQP9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066190.2  
    ENSEMBL proteins: 
     ENSP00000452673   ENSP00000219919   ENSP00000441390  
    Reactome Protein details: O43315

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    antibodies-online antibodies for AQP9 (36 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AQP: Ion channels / Aquaporins

    IUPHAR Guide to PHARMACOLOGY protein family classification: AQP9
    Aquaporins

    4 InterPro protein domains:
     IPR023271 Aquaporin-like
     IPR000425 MIP
     IPR022357 MIP_CS
     IPR015685 Aquaporin_9

    Graphical View of Domain Structure for InterPro Entry O43315

    ProtoNet protein and cluster: O43315

    1 Blocks protein domain: IPB000425 MIP family

    UniProtKB/Swiss-Prot: AQP9_HUMAN, O43315
    Domain: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming
    loop with the signature motif Asn-Pro-Ala (NPA)
    Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family


    Find genes that share domains with AQP9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AQP9_HUMAN, O43315
    Function: Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes
    including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas
    amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to
    urea and glycerol

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005275amine transmembrane transporter activity TAS9733774
    GO:0005345purine nucleobase transmembrane transporter activity IDA9733774
    GO:0005350pyrimidine nucleobase transmembrane transporter activity IDA9733774
    GO:0005372water transmembrane transporter activity TAS9733774
         
    Find genes that share ontologies with AQP9           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for AQP9:
     Increased S DNA content 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Aqp9):
     hematopoietic system  homeostasis/metabolism  immune system 

    Find genes that share phenotypes with AQP9           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Aqp9tm1Nlsn for AQP9

       genOway: Develop your customized and physiologically relevant rodent model for AQP9

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    hsa-miR-607 hsa-miR-522 hsa-miR-485-3p hsa-miR-16-1* hsa-miR-885-5p hsa-miR-3171 hsa-miR-3119 hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidAQP9 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AQP9_HUMAN, O43315: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9514918
    GO:0016020membrane ----
    GO:0016021integral component of membrane NAS9733774
    GO:0016323basolateral plasma membrane IEA--

    Find genes that share ontologies with AQP9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AQP9 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of Water Balance by Renal Aquaporins
    Aquaporin-mediated transport0.85
    Transport of Glycerol from Adipocytes to the Liver by Aquaporins0.00
    Passive Transport by Aquaporins0.00
    2Nanog in Mammalian ESC Pluripotency
    eNOS Signaling0.48
    3Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    4Selected targets of GCR alpha
    Selected targets of GCR alpha
    5Bile secretion
    Bile secretion


    Find genes that share SuperPaths with AQP9           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for AQP9
        eNOS Signaling


    2 Reactome Pathways for AQP9
        Transport of glycerol from adipocytes to the liver by Aquaporins
    Passive transport by Aquaporins


    1 Kegg Pathway  (Kegg details for AQP9):
        Bile secretion

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AQP9: 
              Drug Transporters in human mouse rat
              Osmotic Stress in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for AQP9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for AQP9 (ENSP000002199194) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTL6AENSP000003975524STRING: ENSP00000397552
    MAPK11ENSP000003336854STRING: ENSP00000333685
    MAPK13ENSP000002112874STRING: ENSP00000211287
    MAPK14ENSP000002297944STRING: ENSP00000229794
    ACTL6BENSP000001603824STRING: ENSP00000160382
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS9733774
    GO:0006833water transport TAS--
    GO:0006863purine nucleobase transport IDA9733774
    GO:0006955immune response TAS9514918
    GO:0006970response to osmotic stress TAS9733774

    Find genes that share ontologies with AQP9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AQP9

    2 IUPHAR Ligands for AQP9 (AQP9)    About this table
    LigandTypeActionAffinityPubmed IDs
    Hg2+
    InhibitorNone--
    phloretin
    InhibitorNone--

    6 Novoseek inferred chemical compound relationships for AQP9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycerol 66.9 21 18762715 (2), 18055461 (2), 9514918 (2), 17636116 (1) (see all 10)
    urea 37.7 8 16480766 (3), 9514918 (2), 11597198 (1), 19916714 (1)
    mercury 25.6 2 15561410 (1), 16480766 (1)
    mannitol 15.9 3 16480766 (2)
    lactate 13.1 8 15561412 (3), 16126913 (1), 19916714 (1), 17701333 (1)
    glucose 5.18 1 15561412 (1)



    Find genes that share compounds with AQP9           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AQP9 gene: 
    NM_020980.3  

    Unigene Cluster for AQP9:

    Aquaporin 9
    Hs.104624  [show with all ESTs]
    Unigene Representative Sequence: NM_020980
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000558772 ENST00000219919(uc010ugx.1 uc002aez.2) ENST00000559443
    ENST00000536493
    miRNA
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    hsa-miR-607 hsa-miR-522 hsa-miR-485-3p hsa-miR-16-1* hsa-miR-885-5p hsa-miR-3171 hsa-miR-3119 hsa-miR-3662
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    Additional mRNA sequence: 

    AB008775.1 AF016495.1 AK300055.1 AK313214.1 BC026258.1 CR542027.1 

    3 DOTS entries:

    DT.410734  DT.100755062  DT.95189072 

    Selected AceView cDNA sequences (see all 52):

    AV658659 CB268474 CB154156 AA381471 BU621112 AV656458 AI693953 AI360746 
    CD638629 CA309204 BC026258 AW014829 BX105407 CB164058 BG617142 AB008775 
    CB528930 CB162263 AL601999 AW613564 BM993104 AI719611 CR542027 AA381158 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AQP9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTAGAAGC
    AQP9 Expression
    About this image


    AQP9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Liver (Hepatobiliary System)
             Perivenous Hepatocytes Liver Lobule
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical Veins
    AQP9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AQP9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.104624

    UniProtKB/Swiss-Prot: AQP9_HUMAN, O43315
    Tissue specificity: Highly expressed in peripheral leukocytes. Also expressed in liver, lung, and spleen

        Pathway & Disease-focused RT2 Profiler PCR Arrays including AQP9: 
              Drug Transporters in human mouse rat
              Osmotic Stress in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AQP9 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aqp91 , 5 aquaporin 91, 5 78.76(n)1
    75.59(a)1
      9 (39.85 cM)5
    640081  NM_022026.31  NP_071309.11 
     711106595 
    chicken
    (Gallus gallus)
    Aves AQP91 aquaporin 9 68.44(n)
    64.89(a)
      415402  XM_004943776.1  XP_004943833.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia aqp91 aquaporin 9 63.71(n)
    62.41(a)
      100493943  XM_002937673.2  XP_002937719.1 
    zebrafish
    (Danio rerio)
    Actinopterygii aqp9a1 aquaporin 9a 57.07(n)
    55.04(a)
      606660  NM_001033096.1  NP_001028268.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C01G6.1b3 Major intrinsic protein 42(a)
    (best of 4)
      II(9259518-9261883)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FPS1(YLL043W)4 Plasma membrane channel, member of major intrinsic more   --   12(49938-51947) 850683  NP_013057.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NIP7;11 NIP7;1 48.71(n)
    39.27(a)
      819783  NM_111485.2  NP_566271.1 


    ENSEMBL Gene Tree for AQP9 (if available)
    TreeFam Gene Tree for AQP9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AQP9 gene
    AQP102  AQP32  AQP72  
    5 SIMAP similar genes for AQP9 using alignment to 3 protein entries:     AQP9_HUMAN (see all proteins):
    AQP3    AQP10    AQP7    bA251O17.3    AQP7P3

    Find genes that share paralogs with AQP9           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AQP9 (see all 1275)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs734261541,2
    C,F--35268164(+) CTCACG/AATAAT 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1127389731,2
    F--35268172(+) AATATC/TAATTC 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1137629201,2
    C,F--35268235(+) AATTGC/TGTCTT 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs600242421,2
    C--35269789(+) ACTCAGTCA/-  
            
    TTCAC
    1 -- int11Minor allele frequency- -:0.00NA 2
    rs342917011,2
    C--35287027(+) GCAGG-/ATC/
            
    ATCAT
    2 -- int1 cds10--------
    rs1895134361,2
    C--38490647(+) CATTTC/TTCCAC 1 -- us2k10--------
    rs1808290781,2
    --38490754(+) AGCTCA/GGAGGA 1 -- us2k10--------
    rs1473126781,2
    --38490788(+) CATGTC/TGTATT 1 -- us2k10--------
    rs775294201,2
    C,F--38490850(+) CAAGGC/ACTAGT 1 -- us2k12Minor allele frequency- A:0.05WA EA 238
    rs601791961,2
    C,F--38490962(+) GCATCA/TTGCTG 1 -- us2k13Minor allele frequency- T:0.10WA NA EA 358

    HapMap Linkage Disequilibrium report for AQP9 (58430368 - 58478110 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for AQP9:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665821CNV Deletion23128226
    nsv1550CNV Insertion18451855
    nsv1549CNV Insertion18451855
    nsv833024CNV Loss17160897
    nsv457172CNV Loss19166990
    nsv904263CNV Loss21882294
    nsv904254CNV Gain21882294
    nsv7266OTHER Inversion18451855

    Locus Specific Mutation Databases (LSDB): AQP9

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AQP9
    DNA2.0 Custom Variant and Variant Library Synthesis for AQP9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 602914    OMIM disorders: --

    2 diseases for AQP9:    
    About MalaCards
    hydrarthrosis    polyhydramnios

    2 diseases from the University of Copenhagen DISEASES database for AQP9:
    Hydrarthrosis     Polyhydramnios

    Find genes that share disorders with AQP9           About GenesLikeMe

    1 Novoseek inferred disease relationship for AQP9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    edema 13.7 2 20126625 (1)

    Genetic Association Database (GAD): AQP9
    Human Genome Epidemiology (HuGE) Navigator: AQP9 (4 documents)

    Export disorders for AQP9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for AQP9 gene, integrated from 10 sources (see all 83):
    (articles sorted by number of sources associating them with AQP9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol. (PubMed id 9514918)1, 2, 9 Ishibashi K.... Sasaki S. (Biochem. Biophys. Res. Commun. 1998)
    2. Functional and molecular characterization of the human neutral solute channel aquaporin-9. (PubMed id 10564231)1, 2, 9 Tsukaguchi H.... Hediger M.A. (Am. J. Physiol. 1999)
    3. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    4. Genetic variant in the aquaporin 9 gene is associated with bone mineral density in postmenopausal women. (PubMed id 20960106)1, 4 Chanprasertyothin S....Ongphiphadhanakul B. (Endocrine 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Expression of aquaporin 9 in human chorioamniotic membranes and placenta. (PubMed id 15592307)1, 9 Wang S....Ross M.G. (Am. J. Obstet. Gynecol. 2004)
    8. High levels of human chorionic gonadotropin (hCG) correlate with increased aquaporin-9 (AQP9) expression in explants from human preeclamptic placenta. (PubMed id 20220109)1, 9 Marino G.I....Damiano A.E. (Reprod Sci 2010)
    9. Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in granulosa cells through the phosphatidylinositol 3-kinase pathway. (PubMed id 20378617)1, 9 Qu F....Huang H.F. (Hum. Reprod. 2010)
    10. Fetal membranes as an interface between inflammation and metabolism: increased aquaporin 9 expression in the presence of spontaneous labor at term and chorioamnionitis. (PubMed id 19916714)1, 9 Mittal P....Hassan S.S. (amp 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 366 HGNC: 643 AceView: AQP9 Ensembl:ENSG00000103569 euGenes: HUgn366
    ECgene: AQP9 Kegg: 366 H-InvDB: AQP9

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AQP9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for AQP9 gene:
    Search GeneIP for patents involving AQP9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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