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Aliases for AQP9 Gene

Aliases for AQP9 Gene

  • Aquaporin 9 2 3 5
  • Small Solute Channel 1 3 4
  • Aquaglyceroporin-9 3 4
  • AQP-9 3 4
  • SSC1 3 4
  • HsT17287 3
  • T17287 3

External Ids for AQP9 Gene

Previous GeneCards Identifiers for AQP9 Gene

  • GC15P053987
  • GC15P051477
  • GC15P056009
  • GC15P056146
  • GC15P056217
  • GC15P058430
  • GC15P035253

Summaries for AQP9 Gene

Entrez Gene Summary for AQP9 Gene

  • The aquaporins are a family of water-selective membrane channels. This gene encodes a member of a subset of aquaporins called the aquaglyceroporins. This protein allows passage of a broad range of noncharged solutes and also stimulates urea transport and osmotic water permeability. This protein may also facilitate the uptake of glycerol in hepatic tissue . The encoded protein may also play a role in specialized leukocyte functions such as immunological response and bactericidal activity. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

GeneCards Summary for AQP9 Gene

AQP9 (Aquaporin 9) is a Protein Coding gene. Diseases associated with AQP9 include Infective Endocarditis and Endocarditis. Among its related pathways are Bile secretion and Aquaporin-mediated transport. GO annotations related to this gene include transporter activity and glycerol channel activity. An important paralog of this gene is LOC102724922.

UniProtKB/Swiss-Prot for AQP9 Gene

  • Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol.

Tocris Summary for AQP9 Gene

  • Aquaporins (AQPs) are integral membrane proteins that facilitate the transport of water across biological membranes along an osmotic gradient. There have been 13 AQP isoforms (AQP0-AQP12) identified in humans and rodents to date.

Gene Wiki entry for AQP9 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AQP9 Gene

Genomics for AQP9 Gene

Regulatory Elements for AQP9 Gene

Enhancers for AQP9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AQP9 on UCSC Golden Path with GeneCards custom track

Genomic Location for AQP9 Gene

Chromosome:
15
Start:
58,138,169 bp from pter
End:
58,185,911 bp from pter
Size:
47,743 bases
Orientation:
Plus strand

Genomic View for AQP9 Gene

Genes around AQP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AQP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AQP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AQP9 Gene

Proteins for AQP9 Gene

  • Protein details for AQP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43315-AQP9_HUMAN
    Recommended name:
    Aquaporin-9
    Protein Accession:
    O43315
    Secondary Accessions:
    • Q9NP32

    Protein attributes for AQP9 Gene

    Size:
    295 amino acids
    Molecular mass:
    31431 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AQP9 Gene

Proteomics data for AQP9 Gene at MOPED

Post-translational modifications for AQP9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AQP9 Gene

Antibody Products

No data available for DME Specific Peptides for AQP9 Gene

Domains & Families for AQP9 Gene

Gene Families for AQP9 Gene

HGNC:
IUPHAR :

Protein Domains for AQP9 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for AQP9 Gene

Graphical View of Domain Structure for InterPro Entry

O43315

UniProtKB/Swiss-Prot:

AQP9_HUMAN :
  • Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
  • Belongs to the MIP/aquaporin (TC 1.A.8) family.
Domain:
  • Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Family:
  • Belongs to the MIP/aquaporin (TC 1.A.8) family.
genes like me logo Genes that share domains with AQP9: view

Function for AQP9 Gene

Molecular function for AQP9 Gene

UniProtKB/Swiss-Prot Function:
Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol.

Gene Ontology (GO) - Molecular Function for AQP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005350 pyrimidine nucleobase transmembrane transporter activity IDA 9733774
genes like me logo Genes that share ontologies with AQP9: view

Phenotypes for AQP9 Gene

genes like me logo Genes that share phenotypes with AQP9: view

Animal Models for AQP9 Gene

MGI Knock Outs for AQP9:

Animal Model Products

  • Taconic Biosciences Mouse Models for AQP9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for AQP9 Gene

Localization for AQP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AQP9 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AQP9 Gene COMPARTMENTS Subcellular localization image for AQP9 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for AQP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with AQP9: view

Pathways & Interactions for AQP9 Gene

genes like me logo Genes that share pathways with AQP9: view

Pathways by source for AQP9 Gene

Interacting Proteins for AQP9 Gene

SIGNOR curated interactions for AQP9 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for AQP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA,TAS 9733774
GO:0006833 water transport TAS --
GO:0007588 excretion TAS 9733774
GO:0015791 polyol transport IDA 9733774
GO:0015793 glycerol transport TAS --
genes like me logo Genes that share ontologies with AQP9: view

Drugs & Compounds for AQP9 Gene

(5) Drugs for AQP9 Gene - From: DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hg<sup>2+</sup> Pharma Inhibitor 0
Phloretin Pharma Inhibitor A dihydrochalcone found in apple 0

(3) Additional Compounds for AQP9 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with AQP9: view

Transcripts for AQP9 Gene

Unigene Clusters for AQP9 Gene

Aquaporin 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AQP9 Gene

No ASD Table

Relevant External Links for AQP9 Gene

GeneLoc Exon Structure for
AQP9
ECgene alternative splicing isoforms for
AQP9

Expression for AQP9 Gene

mRNA expression in normal human tissues for AQP9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AQP9 Gene

This gene is overexpressed in Whole Blood (x43.2) and Liver (x5.0).

Protein differential expression in normal tissues from HIPED for AQP9 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (59.1) and Liver (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AQP9 Gene



SOURCE GeneReport for Unigene cluster for AQP9 Gene Hs.104624

mRNA Expression by UniProt/SwissProt for AQP9 Gene

O43315-AQP9_HUMAN
Tissue specificity: Highly expressed in peripheral leukocytes. Also expressed in liver, lung, and spleen.
genes like me logo Genes that share expression patterns with AQP9: view

Protein tissue co-expression partners for AQP9 Gene

Primer Products

Orthologs for AQP9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AQP9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AQP9 35
  • 87.34 (n)
  • 82.71 (a)
AQP9 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AQP9 35
  • 90.4 (n)
  • 90.85 (a)
AQP9 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aqp9 35
  • 78.76 (n)
  • 75.59 (a)
Aqp9 16
Aqp9 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AQP9 35
  • 98.87 (n)
  • 98.64 (a)
AQP9 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aqp9 35
  • 80.56 (n)
  • 75.59 (a)
oppossum
(Monodelphis domestica)
Mammalia AQP9 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AQP9 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves AQP9 35
  • 68.44 (n)
  • 64.89 (a)
AQP9 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia aqp9 35
  • 63.71 (n)
  • 62.41 (a)
zebrafish
(Danio rerio)
Actinopterygii aqp9a 35
  • 57.07 (n)
  • 55.04 (a)
aqp9b 36
  • 52 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C01G6.1a 37
  • 42 (a)
C01G6.1b 37
  • 42 (a)
M02F4.8 37
  • 39 (a)
Y69E1A.7 37
  • 40 (a)
aqp-1 36
  • 32 (a)
ManyToMany
aqp-2 36
  • 38 (a)
ManyToMany
aqp-3 36
  • 25 (a)
ManyToMany
aqp-7 36
  • 36 (a)
ManyToMany
aqp-8 36
  • 32 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL068W 35
  • 44.62 (n)
  • 33.86 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 14 (a)
OneToMany
FPS1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons NIP7;1 35
  • 48.71 (n)
  • 39.27 (a)
Species with no ortholog for AQP9:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AQP9 Gene

ENSEMBL:
Gene Tree for AQP9 (if available)
TreeFam:
Gene Tree for AQP9 (if available)

Paralogs for AQP9 Gene

Paralogs for AQP9 Gene

(5) SIMAP similar genes for AQP9 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with AQP9: view

Variants for AQP9 Gene

Sequence variations from dbSNP and Humsavar for AQP9 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1867380 - 58,184,082(+) TTAAG(A/G)CAGAA reference, missense
rs11857438 -- 58,182,707(+) TACAG(C/T)ATCCT intron-variant
rs11858796 -- 58,171,927(+) TCTCA(A/G)TGTGG intron-variant
rs12437895 -- 58,138,916(+) GTGAG(C/T)GAAGT intron-variant
rs935208 -- 58,171,897(+) ACGAC(C/T)AAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AQP9 Gene

Variant ID Type Subtype PubMed ID
nsv7266 OTHER Inversion 18451855
nsv904254 CNV Gain 21882294
nsv904263 CNV Loss 21882294
nsv1549 CNV Insertion 18451855
nsv457172 CNV Loss 19166990
nsv833024 CNV Loss 17160897
esv2665821 CNV Deletion 23128226
nsv1550 CNV Insertion 18451855

Variation tolerance for AQP9 Gene

Residual Variation Intolerance Score: 46.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.11% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for AQP9 Gene

Disorders for AQP9 Gene

MalaCards: The human disease database

(3) MalaCards diseases for AQP9 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
infective endocarditis
  • endocarditis, infective
endocarditis
hydrarthrosis
- elite association - COSMIC cancer census association via MalaCards
Search AQP9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for AQP9

Genetic Association Database (GAD)
AQP9
Human Genome Epidemiology (HuGE) Navigator
AQP9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AQP9
genes like me logo Genes that share disorders with AQP9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AQP9 Gene

Publications for AQP9 Gene

  1. Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol. (PMID: 9514918) Ishibashi K. … Sasaki S. (Biochem. Biophys. Res. Commun. 1998) 3 4 23 67
  2. High levels of human chorionic gonadotropin (hCG) correlate with increased aquaporin-9 (AQP9) expression in explants from human preeclamptic placenta. (PMID: 20220109) Marino G.I. … Damiano A.E. (Reprod Sci 2010) 3 23
  3. Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in granulosa cells through the phosphatidylinositol 3-kinase pathway. (PMID: 20378617) Qu F. … Huang H.F. (Hum. Reprod. 2010) 3 23
  4. Increased aquaglyceroporin 9 expression disrupts arsenic resistance in human lung cancer cells. (PMID: 19100828) Miao Z.F. … Tsou T.C. (Toxicol In Vitro 2009) 3 23
  5. Aquaporin 9 expression and its localization in normal skeletal myofiber. (PMID: 19629726) Inoue M. … Matsuzaki Y. (J. Mol. Histol. 2009) 3 23

Products for AQP9 Gene

Sources for AQP9 Gene

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