Aliases for AQP9 Gene
Aliases for AQP9 Gene
External Ids for AQP9 Gene
- HGNC: 643
- Entrez Gene: 366
- Ensembl: ENSG00000103569
- OMIM: 602914
- UniProtKB: O43315
Previous GeneCards Identifiers for AQP9 Gene
- GC15P053987
- GC15P051477
- GC15P056009
- GC15P056146
- GC15P056217
- GC15P058430
- GC15P035253
Summaries for AQP9 Gene
-
The aquaporins are a family of water-selective membrane channels. This gene encodes a member of a subset of aquaporins called the aquaglyceroporins. This protein allows passage of a broad range of noncharged solutes and also stimulates urea transport and osmotic water permeability. This protein may also facilitate the uptake of glycerol in hepatic tissue . The encoded protein may also play a role in specialized leukocyte functions such as immunological response and bactericidal activity. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
GeneCards Summary for AQP9 Gene
AQP9 (Aquaporin 9) is a Protein Coding gene. Diseases associated with AQP9 include Endocarditis and Hydrarthrosis. Among its related pathways are Aquaporin-mediated transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity and glycerol channel activity. An important paralog of this gene is AQP10.
UniProtKB/Swiss-Prot for AQP9 Gene
-
Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol.
-
Aquaporins (AQPs) are integral membrane proteins that facilitate the transport of water across biological membranes along an osmotic gradient. There have been 13 AQP isoforms (AQP0-AQP12) identified in humans and rodents to date.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AQP9 Gene
Genomics for AQP9 Gene
Regulatory Elements for AQP9 Gene
- Transcription factor binding sites by QIAGEN in the AQP9 gene promoter:
Regulatory Element Products
Genomic Location for AQP9 Gene
- Chromosome:
- 15
- Start:
- 58,138,169 bp from pter
- End:
- 58,185,911 bp from pter
- Size:
- 47,743 bases
- Orientation:
- Plus strand
Genomic View for AQP9 Gene
- Cytogenetic band:
-
- 15q21.3 by Ensembl
- 15q21.3 by Entrez Gene
- 15q21.3 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AQP9 Gene
Proteins for AQP9 Gene
-
Protein details for AQP9 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O43315-AQP9_HUMAN
- Recommended name:
- Aquaporin-9
- Protein Accession:
- O43315
- Q9NP32
Protein attributes for AQP9 Gene
- Size:
- 295 amino acids
- Molecular mass:
- 31431 Da
- Quaternary structure:
- No Data Available
Protein Expression for AQP9 Gene
Post-translational modifications for AQP9 Gene
Other Protein References for AQP9 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for AQP9
-
Custom Antibody ServicesOriGene Antibodies for AQP9
- Novus Biologicals Antibodies for AQP9
- Invitrogen Antibodies for AQP9
- antibodies-online Antibodies for AQP9: See all 40
- GeneTex AQP9 antibody for AQP9
-
Santa Cruz Biotechnology (SCBT) Antibodies for AQP9
Protein Products
-
OriGene Purified Proteins for AQP9
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Assay Products
- antibodies-online Kits for AQP9: See all 32
No data available for DME Specific Peptides for AQP9 Gene
Domains & Families for AQP9 Gene
Gene Families for AQP9 Gene
- HGNC:
- IUPHAR :
Protein Domains for AQP9 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for AQP9 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O43315UniProtKB/Swiss-Prot:
AQP9_HUMAN :- Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
- Belongs to the MIP/aquaporin (TC 1.A.8) family.
- Domain:
-
- Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
- Family:
-
- Belongs to the MIP/aquaporin (TC 1.A.8) family.
Function for AQP9 Gene
Molecular function for AQP9 Gene
- UniProtKB/Swiss-Prot Function:
- Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005275 | amine transmembrane transporter activity | TAS | 9733774 |
| GO:0005345 | purine nucleobase transmembrane transporter activity | IDA | 9733774 |
| GO:0005350 | pyrimidine nucleobase transmembrane transporter activity | IDA | 9733774 |
| GO:0005372 | water transmembrane transporter activity | TAS | 9733774 |
| GO:0015166 | polyol transmembrane transporter activity | TAS | 9733774 |
Phenotypes for AQP9 Gene
- MGI mutant phenotypes for AQP9:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for AQP9:
Animal Models for AQP9 Gene
- MGI Knock Outs for AQP9:
-
- Aqp9 tm1Nlsn
Animal Model Products
-
Taconic Biosciences Mouse Models for AQP9
- Cyagen custom Knockout/knockin (KOKI) mouse models for AQP9
-
-
ViGene Biosciences lentiviral particle packaged cDNA for AQP9 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AQP9 gene
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CRISPR Products
-
OriGene CRISPR knockouts for AQP9
-
Santa Cruz Biotechnology (SCBT) CRISPR for AQP9
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miRNA Products
- Search ViGene Biosciences for AQP9
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for AQP9 gene
Clone Products
- Sino Biological Human cDNA Clone for AQP9
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- VectorBuilder custom plasmid, inducible vectors for AQP9
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AQP9
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for AQP9
-
ViGene Biosciences adenoviral particle packaged cDNA for AQP9 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for AQP9 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AQP9 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for AQP9 Gene
Localization for AQP9 Gene
Subcellular locations from UniProtKB/Swiss-Prot for AQP9 Gene
- Membrane; Multi-pass membrane protein.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 9514918 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | NAS | 9733774 |
| GO:0016323 | basolateral plasma membrane | IEA | -- |
Pathways & Interactions for AQP9 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Aquaporin-mediated transport | ||
| 2 | Bile secretion | ||
| 3 | Nanog in Mammalian ESC Pluripotency |
.48
|
|
| 4 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||
| 5 | Preimplantation Embryo | ||
Pathways by source for AQP9 Gene
1 BioSystems pathway for AQP9 Gene
1 KEGG pathway for AQP9 Gene
1 Qiagen pathway for AQP9 Gene
Interacting Proteins for AQP9 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | TAS | 9733774 |
| GO:0006833 | water transport | IDA,TAS | -- |
| GO:0006863 | purine nucleobase transport | IDA | 9733774 |
| GO:0006955 | immune response | TAS | 9514918 |
| GO:0006970 | response to osmotic stress | TAS | 9733774 |
Transcripts for AQP9 Gene
mRNA/cDNA for AQP9 Gene
- (3) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (52) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for AQP9
-
Santa Cruz Biotechnology (SCBT) CRISPR for AQP9
- GenScript: Design CRISPR guide RNA sequences for AQP9
miRNA Products
- Search ViGene Biosciences for AQP9
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for AQP9
- Browse OriGene Inhibitory RNA Products For AQP9
-
ViGene Biosciences ready-to-package AAV shRNAs for AQP9 gene
Clone Products
- Sino Biological Human cDNA Clone for AQP9
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for AQP9
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AQP9
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for AQP9 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
-
Liver (Hepatobiliary System)
- Perivenous Hepatocytes Liver Lobule
- Umbilical Cord (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for AQP9 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AQP9 Gene
NURSA nuclear receptor signaling pathways regulating expression of AQP9 Gene:
AQP9SOURCE GeneReport for Unigene cluster for AQP9 Gene:
Hs.104624mRNA Expression by UniProt/SwissProt for AQP9 Gene:
O43315-AQP9_HUMANEvidence on tissue expression from TISSUES for AQP9 Gene
- Liver(4.7)
- Blood(2.8)
Primer Products
-
OriGene qPCR primer pairs for AQP9
-
OriGene qPCR primer pairs and template standards for AQP9
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AQP9 Gene
Orthologs for AQP9 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | AQP9 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | AQP9 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | AQP9 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Aqp9 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Aqp9 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | AQP9 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | AQP9 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | AQP9 34 35 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | aqp9 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | aqp9a 34 |
|
||
| aqp9b 35 |
|
OneToOne | |||
| worm (Caenorhabditis elegans) |
Secernentea | C01G6.1a 36 |
|
|
|
| C01G6.1b 36 |
|
|
|||
| Y69E1A.7 36 |
|
|
|||
| M02F4.8 36 |
|
|
|||
| aqp-2 35 |
|
ManyToMany | |||
| aqp-7 35 |
|
ManyToMany | |||
| aqp-1 35 |
|
ManyToMany | |||
| aqp-8 35 |
|
ManyToMany | |||
| aqp-3 35 |
|
ManyToMany | |||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ACL068W 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 35 |
|
OneToMany | |
| FPS1 37 |
|
|
|||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | NIP7;1 34 |
|
- Species where no ortholog for AQP9 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for AQP9 Gene
(5) SIMAP similar genes for AQP9 Gene using alignment to 3 proteins:
Variants for AQP9 Gene
| SNP ID | Clin | Chr 15 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000086486 | -- | 58,141,675(+) | TGCTC(C/G/T)TACCT | intron-variant | |
| rs1000143137 | -- | 58,155,482(+) | GCCAC(C/G)CTTAC | intron-variant | |
| rs1000196460 | -- | 58,138,303(+) | CAGGC(A/G)CAAAA | intron-variant, utr-variant-5-prime | |
| rs1000284371 | -- | 58,184,645(+) | CTACT(A/G)GATTT | intron-variant, utr-variant-3-prime | |
| rs1000358730 | -- | 58,179,436(+) | AGTTC(A/C)GATGA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2665821 | CNV | deletion | 23128226 |
| esv3636625 | CNV | loss | 21293372 |
| nsv1047246 | CNV | gain | 25217958 |
| nsv1134452 | CNV | deletion | 24896259 |
| nsv1549 | CNV | insertion | 18451855 |
| nsv1550 | CNV | insertion | 18451855 |
| nsv457172 | CNV | loss | 19166990 |
| nsv569597 | CNV | loss | 21841781 |
| nsv7266 | OTHER | inversion | 18451855 |
| nsv833024 | CNV | loss | 17160897 |
| nsv974582 | CNV | duplication | 23825009 |
Relevant External Links for AQP9 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- AQP9
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AQP9 Gene
Disorders for AQP9 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| endocarditis |
|
|
| hydrarthrosis |
|
|
Relevant External Links for AQP9
No data available for UniProtKB/Swiss-Prot and Genatlas for AQP9 Gene
Publications for AQP9 Gene
- Functional and molecular characterization of the human neutral solute channel aquaporin-9. (PMID: 10564231) Tsukaguchi H. … Hediger M.A. (Am. J. Physiol. 1999) 3 4 22 64
- Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol. (PMID: 9514918) Ishibashi K. … Sasaki S. (Biochem. Biophys. Res. Commun. 1998) 3 4 22 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K. … Hosoya T. (Nephron Clin Pract 2010) 3 46 64
- High levels of human chorionic gonadotropin (hCG) correlate with increased aquaporin-9 (AQP9) expression in explants from human preeclamptic placenta. (PMID: 20220109) Marino G.I. … Damiano A.E. (Reprod Sci 2010) 3 22 64
Products for AQP9 Gene
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- antibodies-online Antibodies for AQP9: See all 40
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- Santa Cruz Biotechnology (SCBT) Antibodies for AQP9
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- Horizon Cell Lines for AQP9
- Cyagen custom Knockout/knockin (KOKI) mouse models for AQP9
- VectorBuilder custom plasmid, inducible vectors for AQP9
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AQP9
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for AQP9 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
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- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
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- (115) ProteomicsDB
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- (141) ENCODE
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- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




