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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

AQP8 Gene

protein-coding GIFtS: 55
GCID: GC16P025227

aquaporin 8

Explore 18 diseases affiliated with
AQP8 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Aquaporin 8¹ ²
AQP-8² ³
Aquaporin-8¹

External Ids:	HGNC: 642¹	Entrez Gene: 343²	Ensembl: ENSG00000103375⁷	OMIM: 603750⁵	UniProtKB: O94778³

Export aliases for AQP8 gene to outside databases

Previous GC identifers: GC16M024599 GC16P025327 GC16P025154 GC16P025193 GC16P025194 GC16P025135 GC16P023321

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AQP8:

Aquaporin 8 (AQP8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to

the major intrinsic protein (MIP or AQP0). Aquaporin 8 mRNA is found in pancreas and colon but not other tissues.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: AQP8_HUMAN, O94778

Function: Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea

Gene Wiki entry for AQP8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the AQP8 gene promoter:
Max1 Bach1 AREB6 PPAR-gamma1 HNF-1 HOXA5 COMP1 PPAR-gamma2 Ik-1 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: AQP8 promoter sequence

Search SABiosciences Chromatin IP Primers for AQP8

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AQP8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12 Ensembl cytogenetic band: 16p12.1 HGNC cytogenetic band: 16p12

AQP8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AQP8 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P025227: view genomic region (about GC identifiers)

Start:	25,227,052 bp from pter	End:	25,240,261 bp from pter
Size:	13,210 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AQP8_HUMAN, O94778 (See protein sequence)

Recommended Name: Aquaporin-8

Size: 261 amino acids; 27381 Da

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: Q8IUU3 Q9UIA4

Explore the universe of human proteins at neXtProt for AQP8: NX_O94778

AQP8 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001160.2

ENSEMBL proteins:

ENSP00000454457 ENSP00000219660

Reactome Protein details: O94778
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for AQP8

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005792	microsome	--	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	9806845
GO:0043231	intracellular membrane-bounded organelle	IEA	--
GO:0045177	apical part of cell	IDA	12801959

AQP8 for ontologies About GeneDecksing

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Assay Products for AQP8:

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	GenScript Custom Assay Services for AQP8
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for AQP8

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

AQP8 for domains About GeneDecksing

4 InterPro domains/families:

IPR022357 MIP_CS

IPR023271 Aquaporin-like

IPR023277 Aquaporin_8

IPR000425 MIP

Graphical View of Domain Structure for InterPro Entry O94778

ProtoNet protein and cluster: O94778

1 Blocks protein family: IPB000425 MIP family

UniProtKB/Swiss-Prot: AQP8_HUMAN, O94778

Domain: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop

with the signature motif Asn-Pro-Ala (NPA)

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: AQP8_HUMAN, O94778

Function: Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea

Genatlas biochemistry entry for AQP8:

aquaporin 8,water channel forming integral protein,MIP family,selectively expressed in the pancreas and colon

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AQP8
		1 QIAGEN miScript miRNA Assays for microRNA that regulate AQP8:
		hsa-miR-518a-5p
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AQP8 (see all 7) OriGene shRNA RFP: AQP8 OriGene siRNA: AQP8
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AQP8

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0015250	water channel activity	TAS	9806845

AQP8 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Aqp8^tm1Ask for AQP8
     5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Aqp8):

digestive/alimentary

endocrine/exocrine gland

homeostasis/metabolism

renal/urinary system

reproductive system

AQP8 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Passive Transport by Aquaporins

Passive Transport by Aquaporins

1.00

Bile secretion

Bile secretion

1.00

Regulation of Water Balance by Renal Aquaporins

Aquaporin-mediated transport

0.84

SLC-mediated transmembrane transport

Transmembrane transport of small molecules

0.50

Nanog in Mammalian ESC Pluripotency

eNOS Signaling

0.48

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for AQP8

eNOS Signaling

3 Reactome Pathways for AQP8

	Transmembrane transport of small molecules
	Aquaporin-mediated transport
	Passive Transport by Aquaporins

1 Kegg Pathway (Kegg details for AQP8):

Bile secretion

AQP8 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for AQP8

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	TAS	9806845
GO:0006833	water transport	TAS	--
GO:0015722	canalicular bile acid transport	IEA	--
GO:0055085	transmembrane transport	TAS	--
GO:0071320	cellular response to cAMP	IEP	17636236

AQP8 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

AQP8 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for AQP8
3 Novoseek chemical compound relationships for AQP8 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glycerol	44.5	4	9806845 (1), 15948717 (1), 17044001 (1), 20149227 (1)
ammonium	23.8	2	15948717 (2)
forskolin	20.4	2	17636236 (1), 12712100 (1)

Search CenterWatch for drugs/clinical trials and news about AQP8

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for AQP8 gene:

NM_001169.2

Unigene Cluster for AQP8:

Aquaporin 8

Hs.176658 [show with all ESTs]

Unigene Representative Sequence: BM923471

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000566125 ENST00000219660(uc002doc.3)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat AQP8
		1 QIAGEN miScript miRNA Assays for microRNA that regulate AQP8:
		hsa-miR-518a-5p
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AQP8 (see all 7) OriGene shRNA RFP: AQP8 OriGene siRNA: AQP8
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AQP8

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AQP8 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AQP8 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AQP8 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AQP8
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AQP8

Additional cDNA sequence:

AB013456.1 AF067797.1 AK222964.1 AK222975.1 BC040630.1

2 DOTS entries:

DT.40122395 DT.97807192

24/47 AceView cDNA sequences (see all 47):

BG982517 NM_001169 AA577625 BC040630 BG185785 BG200858 BG188929 BI517570

AB013456 AF067797 BG204865 BG221055 CA865552 BG217572 BM923471 BG984960

AW083143 AW138645 AI732659 AI791955 BG205480 BG221545 BG191532 BQ326472

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

AQP8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATCCCGCCC

About this image

AQP8 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See AQP8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AQP8

SOURCE GeneReport for Unigene cluster: Hs.176658

UniProtKB/Swiss-Prot: AQP8_HUMAN, O94778

Tissue specificity: Expressed only in pancreas and colon

SABiosciences Custom PCR Arrays for AQP8

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AQP8

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AQP8

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for AQP8 gene from 6/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	AQP8¹	aquaporin 8	64.36(n) 57.58(a)		416566 XM_414866.2 XP_414866.2
zebrafish (Danio rerio)	Actinopterygii	aqp8a.1¹	aquaporin 8a, tandem duplicate 1	59.37(n) 53.65(a)		447923 NM_001004661.1 NP_001004661.1
fruit fly (Drosophila melanogaster)	Insecta	CG17662¹	CG17662	48.94(n) 34.89(a)		37738 NM_137968.2 NP_611812.2
worm (Caenorhabditis elegans)	Secernentea	aqp-5¹	Protein AQP-5	43.74(n) 37.56(a)		183221 NM_073290.2 NP_505691.2
thale cress (Arabidopsis thaliana)	eudicotyledons	DELTA-TIP1⁶ ATTIP2;3⁶ (see all 10)	aquaporin TIP2-3 (see all 10)	33(a) 33(a) (see all 10)	1 ↔ many 1 ↔ many (see all 10)	3(5505404-5507050) 5(19248249-19249504)
rice (Oryza sativa)	Liliopsida	-- -- (see all 10)	aquaporin protein, putative, expressed (see all 10)	33(a) 32(a) (see all 10)	1 ↔ many 1 ↔ many (see all 10)	2(26602492-26603789) 6(13406320-13407860)

ENSEMBL Gene Tree for AQP8 (if available)
TreeFam Gene Tree for AQP8 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for AQP8 gene

ENSG00000250424² AQP2² MIP² AQP5² AQP1² AQP4² AQP6²

5 SIMAP similar genes for AQP8 using alignment to 2 protein entries: AQP8_HUMAN (see all proteins):

AQP5 AQP6 AQP1 MIP AQP2

AQP8 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7499578^1,2	C,F,A,H,	--	25226313(+)	`CAGCAA/TTTGGA`	1	--	us2k¹		11		NA WA EA	378
rs141065507^1,2		--	25226410(+)	`ACAGGA/TAATCT`	1	--	us2k¹		0	--	--	--	--
rs185634451^1,2		--	25226416(+)	`AATCTA/GTACCC`	1	--	us2k¹		0	--	--	--	--
rs145026105^1,2		--	25226455(+)	`CCCCTC/TGGGCC`	1	--	us2k¹		0	--	--	--	--
rs138714216^1,2		--	25226460(+)	`CGGGCC/GGTGGA`	1	--	us2k¹		0	--	--	--	--
rs148964133^1,2		--	25226505(+)	`CTAGTC/TTAGGT`	1	--	us2k¹		0	--	--	--	--
rs143699020^1,2		--	25226508(+)	`GTCTAA/GGTACT`	1	--	us2k¹		0	--	--	--	--
rs148106411^1,2		--	25226518(+)	`TTCATA/GCAAGT`	1	--	us2k¹		0	--	--	--	--
rs190104249^1,2		--	25226533(+)	`TCAGAC/TACAGT`	1	--	us2k¹		0	--	--	--	--
rs73551005^1,2	C,	--	25226628(+)	`TTCCTC/AGNNNN`	1	--	us2k¹		3		WA NA	240

HapMap Linkage Disequilibrium report for AQP8 (25227052 - 25240261 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for AQP8
4 CNVs: 88019 88018 58758 77233

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AQP8

DNA2.0 Custom Variant and Variant Library Synthesis for AQP8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

AQP8 for disorders           About GeneDecksing

OMIM gene information: 603750    OMIM disorders: --

18 diseases for AQP8:    About MalaCards

nephrogenic diabetes insipidus diabetes insipidus inflammatory bowel disease irritable bowel syndrome

oligohydramnios polyhydramnios ulcerative colitis cholestasis

crohn's disease diarrhea liver disease cervical carcinoma

hepatocellular carcinoma cervicitis peritonitis pneumonia

carcinoma sepsis

1 disease from the University of Copenhagen DISEASES database for AQP8:

Oligohydramnios

2 Novoseek disease relationships for AQP8 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
colitis ulcerative	29.7	2	18467915 (1), 17461471 (1)
inflammatory bowel diseases	27.6	2	18467915 (1), 15338270 (1)

Human Genome Epidemiology (HuGE) Navigator: AQP8 (1 document)

Export disorders for AQP8 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for AQP8 gene, integrated from 9 sources (see all 48):
(articles sorted by number of sources associating them with AQP8)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and functional expression of human aquaporin8 cDNA and analysis of its gene. (PubMed id 9806845)^{1, 2, 3, 9} Koyama N....Marumo F. (1998)
Assignment of the aquaporin-8 water channel gene (AQP 8) to human chromosome 16p12. (PubMed id 10393433)^{1, 3, 9} Viggiano L....Calamita G. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
[Relationship between cyclic adenosine monophosphate and auqaporin 8 expression and distribution in human amnion-derived cells] (PubMed id 19087520)^{1, 9} Li L. and Qi H.B. (2008)
[Expression of aquaporin-8 and bcl-2 protein in human cervical carcinoma and their correlations] (PubMed id 18788571)^{1, 9} Yao J.F....Shi Y.F. (2008)
Knockdown of hepatocyte aquaporin-8 by RNA interference induces defective bile canalicular water transport. (PubMed id 18948439)^{1, 9} Larocca M.C....Marinelli R.A. (2009)
[Expression of aquaporin 8 in human fetal membrane an d placenta of idiopathic polyhydramnios] (PubMed id 19563057)^{1, 9} Huang J. and Qi H.B. (2009)
Expression of aquaporin 8 is diversely regulated by o smotic stress in amnion epithelial cells. (PubMed id 20144166)^{1, 9} Qi H....Huang J. (2009)
Expression of aquaporin 8 and its up-regulation by cyclic adenosine monophosphate in human WISH cells. (PubMed id 12712100)^{1, 9} Wang S....Ross M.G. (2003)
Expression of aquaporin-8 in human placenta and chorioamniotic membranes: evidence of molecular mechanism for intramembranous amniotic fluid resorption. (PubMed id 11717661)^{1, 9} Wang S....Ross M.G. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 343	HGNC: 642	AceView: AQP8	Ensembl:ENSG00000103375	euGenes: HUgn343
ECgene: AQP8	Kegg: 343	H-InvDB: AQP8

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for AQP8	Pharmacogenomics, SNPs, Pathways

Intellectual Property for AQP8 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for AQP8 gene:
Search GeneIP for patents involving AQP8

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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