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Aliases for AQP8 Gene

Aliases for AQP8 Gene

  • Aquaporin 8 2 3
  • AQP-8 3 4
  • Aquaporin-8 3

External Ids for AQP8 Gene

Previous GeneCards Identifiers for AQP8 Gene

  • GC16M024599
  • GC16P025327
  • GC16P025154
  • GC16P025193
  • GC16P025194
  • GC16P025135
  • GC16P023321
  • GC16P025227

Summaries for AQP8 Gene

Entrez Gene Summary for AQP8 Gene

  • Aquaporin 8 (AQP8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 8 mRNA is found in pancreas and colon but not other tissues. [provided by RefSeq, Jul 2008]

GeneCards Summary for AQP8 Gene

AQP8 (Aquaporin 8) is a Protein Coding gene. Diseases associated with AQP8 include polyhydramnios and oligohydramnios. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Cellular Senescence. GO annotations related to this gene include water channel activity. An important paralog of this gene is AQP1.

UniProtKB/Swiss-Prot for AQP8 Gene

  • Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea

Tocris Summary for AQP8 Gene

  • Aquaporins (AQPs)�are integral membrane proteins that facilitate the transport of water across biological membranes along an osmotic gradient. There have been 13 AQP isoforms (AQP0-AQP12) identified in humans and rodents to date.

Gene Wiki entry for AQP8 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AQP8 Gene

Genomics for AQP8 Gene

Regulatory Elements for AQP8 Gene

Genomic Location for AQP8 Gene

Start:
25,215,731 bp from pter
End:
25,228,940 bp from pter
Size:
13,210 bases
Orientation:
Plus strand

Genomic View for AQP8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AQP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AQP8 Gene

Proteins for AQP8 Gene

  • Protein details for AQP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94778-AQP8_HUMAN
    Recommended name:
    Aquaporin-8
    Protein Accession:
    O94778
    Secondary Accessions:
    • Q8IUU3
    • Q9UIA4

    Protein attributes for AQP8 Gene

    Size:
    261 amino acids
    Molecular mass:
    27381 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AQP8 Gene

Proteomics data for AQP8 Gene at MOPED

Post-translational modifications for AQP8 Gene

  • Glycosylation at Asn59 and Asn139

Other Protein References for AQP8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for AQP8 Gene

Domains for AQP8 Gene

Gene Families for AQP8 Gene

HGNC:
  • AQP :Ion channels / Aquaporins
IUPHAR :

Protein Domains for AQP8 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for AQP8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94778

UniProtKB/Swiss-Prot:

AQP8_HUMAN :
  • O94778
Domain:
  • Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)
Family:
  • Belongs to the MIP/aquaporin (TC 1.A.8) family.
genes like me logo Genes that share domains with AQP8: view

Function for AQP8 Gene

Molecular function for AQP8 Gene

GENATLAS Biochemistry: aquaporin 8,water channel forming integral protein,MIP family,selectively expressed in the pancreas and colon
UniProtKB/Swiss-Prot Function: Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea

Gene Ontology (GO) - Molecular Function for AQP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0015250 water channel activity TAS 9806845
GO:0015254 glycerol channel activity IBA --
genes like me logo Genes that share ontologies with AQP8: view
genes like me logo Genes that share phenotypes with AQP8: view

Animal Models for AQP8 Gene

MGI Knock Outs for AQP8:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AQP8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for AQP8 Gene

Localization for AQP8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AQP8 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AQP8 Gene COMPARTMENTS Subcellular localization image for AQP8 gene
Compartment Confidence
plasma membrane 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for AQP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9806845
GO:0016020 membrane --
GO:0043231 intracellular membrane-bounded organelle IEA --
GO:0045177 apical part of cell IDA 12801959
genes like me logo Genes that share ontologies with AQP8: view

Pathways for AQP8 Gene

genes like me logo Genes that share pathways with AQP8: view

Pathways by source for AQP8 Gene

Interacting Proteins for AQP8 Gene

Gene Ontology (GO) - Biological Process for AQP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000302 response to reactive oxygen species TAS --
GO:0006810 transport TAS 9806845
GO:0006833 water transport TAS --
GO:0009992 cellular water homeostasis IBA --
GO:0015722 canalicular bile acid transport IEA --
genes like me logo Genes that share ontologies with AQP8: view

Compounds for AQP8 Gene

(1) IUPHAR Ligand for AQP8 Gene

Ligand Type Action Affinity Pubmed IDs
Hg2+ Inhibitor None

(3) Novoseek inferred chemical compound relationships for AQP8 Gene

Compound -log(P) Hits PubMed IDs
glycerol 44.5 4
ammonium 23.8 2
forskolin 20.4 2
genes like me logo Genes that share compounds with AQP8: view

Transcripts for AQP8 Gene

mRNA/cDNA for AQP8 Gene

Unigene Clusters for AQP8 Gene

Aquaporin 8:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AQP8

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for AQP8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AQP8 Gene

No ASD Table

Relevant External Links for AQP8 Gene

GeneLoc Exon Structure for
AQP8
ECgene alternative splicing isoforms for
AQP8

Expression for AQP8 Gene

mRNA expression in normal human tissues for AQP8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AQP8 Gene

This gene is overexpressed in Pancreas (36.5) and Colon - Transverse (14.9).

SOURCE GeneReport for Unigene cluster for AQP8 Gene Hs.176658

mRNA Expression by UniProt/SwissProt for AQP8 Gene

O94778-AQP8_HUMAN
Tissue specificity: Expressed only in pancreas and colon
genes like me logo Genes that share expressions with AQP8: view

In Situ Assay Products

No data available for Protein expression for AQP8 Gene

Orthologs for AQP8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AQP8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AQP8 35
  • 99.11 (n)
  • 99.23 (a)
AQP8 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AQP8 35
  • 83.4 (n)
  • 80.93 (a)
AQP8 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AQP8 35
  • 86.85 (n)
  • 87.74 (a)
AQP8 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aqp8 35
  • 78.21 (n)
  • 76.54 (a)
Aqp8 16
Aqp8 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AQP8 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AQP8 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aqp8 35
  • 78.42 (n)
  • 75.48 (a)
chicken
(Gallus gallus)
Aves AQP8 35
  • 63.19 (n)
  • 56.67 (a)
AQP8 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 29 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia aqp8 35
  • 66.13 (n)
  • 69.35 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14059 35
zebrafish
(Danio rerio)
Actinopterygii aqp8a.1 35
  • 58.95 (n)
  • 52.48 (a)
aqp8a.1 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta bib 36
  • 10 (a)
ManyToMany
CG17662 36
  • 27 (a)
ManyToMany
CG17664 36
  • 26 (a)
ManyToMany
CG4019 36
  • 24 (a)
ManyToMany
CG5398 36
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea aqp-4 36
  • 30 (a)
OneToMany
aqp-5 35
  • 44.22 (n)
  • 38.27 (a)
aqp-5 36
  • 24 (a)
OneToMany
aqp-6 36
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 26 (a)
ManyToMany
AQY1 36
  • 21 (a)
ManyToMany
AQY2 36
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
CSA.5890 36
  • 24 (a)
OneToMany
CSA.6166 36
  • 32 (a)
OneToMany
Species with no ortholog for AQP8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AQP8 Gene

ENSEMBL:
Gene Tree for AQP8 (if available)
TreeFam:
Gene Tree for AQP8 (if available)

Paralogs for AQP8 Gene

Paralogs for AQP8 Gene

Selected SIMAP similar genes for AQP8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with AQP8: view

Variants for AQP8 Gene

Sequence variations from dbSNP and Humsavar for AQP8 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs875445 -- 25,222,678(-) CCCCC(A/C)CACAC intron-variant
rs889118 -- 25,223,857(-) agagc(A/G)agact intron-variant
rs1076973 -- 25,223,123(+) GTATC(A/G)TCCCT intron-variant
rs1076974 -- 25,223,350(+) GTCCT(A/G)TGGGG intron-variant
rs2002522 -- 25,222,404(-) cacag(C/T)gagag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AQP8 Gene

Variant ID Type Subtype PubMed ID
esv2668763 CNV Deletion 23128226
nsv820298 CNV Gain 19587683

Relevant External Links for AQP8 Gene

HapMap Linkage Disequilibrium report
AQP8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AQP8 Gene

Disorders for AQP8 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for AQP8 Gene including...

Search for AQP8 Gene in MalaCards »

(1) University of Copenhagen DISEASES for AQP8 Gene

(2) Novoseek inferred disease relationships for AQP8 Gene

Disease -log(P) Hits PubMed IDs
colitis ulcerative 29.7 2
inflammatory bowel diseases 27.6 2

Relevant External Links for AQP8

Genetic Association Database (GAD)
AQP8
Human Genome Epidemiology (HuGE) Navigator
AQP8
genes like me logo Genes that share disorders with AQP8: view

No data available for UniProtKB/Swiss-Prot for AQP8 Gene

Publications for AQP8 Gene

  1. Cloning and functional expression of human aquaporin8 cDNA and analysis of its gene. (PMID: 9806845) Koyama N. … Marumo F. (Genomics 1998) 2 3 4 23
  2. Assignment of the aquaporin-8 water channel gene (AQP8) to human chromosome 16p12. (PMID: 10393433) Viggiano L. … Calamita G. (Cytogenet. Cell Genet. 1999) 2 3 23
  3. Aquaporin-8 expression is reduced in ileum and induced in colon of patients with ulcerative colitis. (PMID: 17461471) Zahn A. … Schmitz G. (World J. Gastroenterol. 2007) 3 23
  4. Cyclic adenosine monophosphate regulation of aquaporin gene expression in human amnion epithelia. (PMID: 17636236) Shengbiao Wang . … Ross M.G. (Reprod Sci 2007) 3 23
  5. [Relationship between cyclic adenosine monophosphate and aquaporin 8 expression and distribution in human amnion-derived cells]. (PMID: 19087520) Li L. … Qi H.B. (Zhonghua Fu Chan Ke Za Zhi 2008) 3 23

Products for AQP8 Gene

Sources for AQP8 Gene

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