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AQP8 Gene

protein-coding   GIFtS: 57
GCID: GC16P025227

Aquaporin 8

  See AQP8-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Aquaporin 81 2
AQP-82 3
aquaporin-82

External Ids:    HGNC: 6421   Entrez Gene: 3432   Ensembl: ENSG000001033757   OMIM: 6037505   UniProtKB: O947783   

Export aliases for AQP8 gene to outside databases

Previous GC identifers: GC16M024599 GC16P025327 GC16P025154 GC16P025193 GC16P025194 GC16P025135 GC16P023321


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AQP8 Gene:
Aquaporin 8 (AQP8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related
to the major intrinsic protein (MIP or AQP0). Aquaporin 8 mRNA is found in pancreas and colon but not other
tissues. (provided by RefSeq, Jul 2008)

GeneCards Summary for AQP8 Gene:
AQP8 (aquaporin 8) is a protein-coding gene. Diseases associated with AQP8 include oligohydramnios, and polyhydramnios. GO annotations related to this gene include water channel activity. An important paralog of this gene is ENSG00000250424.

UniProtKB/Swiss-Prot: AQP8_HUMAN, O94778
Function: Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea

Gene Wiki entry for AQP8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the AQP8 gene promoter:
         Max1   Bach1   AREB6   PPAR-gamma1   HNF-1   HOXA5   COMP1   PPAR-gamma2   Ik-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAQP8 promoter sequence
   Search Chromatin IP Primers for AQP8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AQP8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12   Ensembl cytogenetic band:  16p12.1   HGNC cytogenetic band: 16p12

AQP8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AQP8 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P025227:  view genomic region     (about GC identifiers)

Start:
25,227,052 bp from pter      End:
25,240,261 bp from pter
Size:
13,210 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AQP8_HUMAN, O94778 (See protein sequence)
Recommended Name: Aquaporin-8  
Size: 261 amino acids; 27381 Da
Secondary accessions: Q8IUU3 Q9UIA4

Explore the universe of human proteins at neXtProt for AQP8: NX_O94778

Explore proteomics data for AQP8 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn59, Asn139

  • See AQP8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001160.2  
    ENSEMBL proteins: 
     ENSP00000454457   ENSP00000219660  
    Reactome Protein details: O94778

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    antibodies-online peptides for AQP8

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    antibodies-online antibodies for AQP8 (48 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AQP: Ion channels / Aquaporins

    IUPHAR Guide to PHARMACOLOGY protein family classification: AQP8
    Aquaporins

    4 InterPro protein domains:
     IPR023271 Aquaporin-like
     IPR023277 Aquaporin_8
     IPR000425 MIP
     IPR022357 MIP_CS

    Graphical View of Domain Structure for InterPro Entry O94778

    ProtoNet protein and cluster: O94778

    1 Blocks protein domain: IPB000425 MIP family

    UniProtKB/Swiss-Prot: AQP8_HUMAN, O94778
    Domain: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming
    loop with the signature motif Asn-Pro-Ala (NPA)
    Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family


    Find genes that share domains with AQP8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AQP8_HUMAN, O94778
    Function: Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea

         Genatlas biochemistry entry for AQP8:
    aquaporin 8,water channel forming integral protein,MIP family,selectively expressed in the pancreas and colon

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0015250water channel activity TAS9806845
         
    Find genes that share ontologies with AQP8           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Aqp8):
     digestive/alimentary  endocrine/exocrine gland  homeostasis/metabolism  renal/urinary system  reproductive system 

    Find genes that share phenotypes with AQP8           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Aqp8tm1Ask for AQP8

       genOway: Develop your customized and physiologically relevant rodent model for AQP8

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidAQP8 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AQP8_HUMAN, O94778: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9806845
    GO:0016020membrane ----
    GO:0043231intracellular membrane-bounded organelle IEA--
    GO:0045177apical part of cell IDA12801959

    Find genes that share ontologies with AQP8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AQP8 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Regulation of Water Balance by Renal Aquaporins
    Aquaporin-mediated transport0.85
    Passive Transport by Aquaporins0.00
    2Cellular Senescence
    Cellular responses to stress0.81
    3Nanog in Mammalian ESC Pluripotency
    eNOS Signaling0.48
    4Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    5Detoxification of Reactive Oxygen Species
    Detoxification of Reactive Oxygen Species


    Find genes that share SuperPaths with AQP8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for AQP8
        eNOS Signaling

    2 Reactome Pathways for AQP8
        Detoxification of Reactive Oxygen Species
    Passive transport by Aquaporins


    1 Kegg Pathway  (Kegg details for AQP8):
        Bile secretion

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AQP8
    Interactions:

        Search GeneGlobe Interaction Network for AQP8

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for AQP8 (ENSP000002196604) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DPYDENSP000003592114STRING: ENSP00000359211
    FDXRENSP000002931954STRING: ENSP00000293195
    SLC36A1ENSP000002433894STRING: ENSP00000243389
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS9806845
    GO:0006833water transport TAS--
    GO:0015722canalicular bile acid transport IEA--
    GO:0055085transmembrane transport TAS--
    GO:0071320cellular response to cAMP IEP17636236

    Find genes that share ontologies with AQP8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AQP8

    1 IUPHAR Ligand for AQP8 (AQP8)    About this table
    LigandTypeActionAffinityPubmed IDs
    Hg2+
    InhibitorNone--

    3 Novoseek inferred chemical compound relationships for AQP8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycerol 44.5 4 9806845 (1), 15948717 (1), 17044001 (1), 20149227 (1)
    ammonium 23.8 2 15948717 (2)
    forskolin 20.4 2 17636236 (1), 12712100 (1)



    Find genes that share compounds with AQP8           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AQP8 gene: 
    NM_001169.2  

    Unigene Cluster for AQP8:

    Aquaporin 8
    Hs.176658  [show with all ESTs]
    Unigene Representative Sequence: BM923471
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000566125 ENST00000219660(uc002doc.3)
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AB013456.1 AF067797.1 AK222964.1 AK222975.1 BC040630.1 

    2 DOTS entries:

    DT.40122395  DT.97807192 

    Selected AceView cDNA sequences (see all 47):

    BG982517 NM_001169 BC040630 AA577625 AI732659 AB013456 CA865552 BG204865 
    BG185785 BG200858 AF067797 BG984960 BM923471 BI517570 AW138645 AW083143 
    BG221055 BG188929 BG217572 BG191532 AI791955 BG982630 BG218608 BG221545 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AQP8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATCCCGCCC
    AQP8 Expression
    About this image


    AQP8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule
     
     Colon (Gastrointestinal Tract)
     
     Pancreas (Endocrine System)
    AQP8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AQP8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.176658

    UniProtKB/Swiss-Prot: AQP8_HUMAN, O94778
    Tissue specificity: Expressed only in pancreas and colon

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AQP8 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aqp81 , 5 aquaporin 81, 5 78.21(n)1
    76.54(a)1
      7 (67.42 cM)5
    118331  NM_007474.21  NP_031500.11 
     1234622945 
    chicken
    (Gallus gallus)
    Aves AQP81 aquaporin 8 63.19(n)
    56.67(a)
      416566  XM_414866.3  XP_414866.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    29(a)
    many ↔ many
    2(93186011-93195185)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia aqp81 aquaporin 8 66.13(n)
    69.35(a)
      100135726  NM_001114256.1  NP_001107728.1 
    zebrafish
    (Danio rerio)
    Actinopterygii aqp8a.11 aquaporin 8a, tandem duplicate 1 58.95(n)
    52.48(a)
      447923  NM_001004661.1  NP_001004661.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG176626
    CG176646
    (see all 5)
    --
    27(a)
    26(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    2R(19493281-19494177)
    2R(19491249-19492676)
    worm
    (Caenorhabditis elegans)
    Secernentea aqp-51 aqp-5 44.22(n)
    38.27(a)
      183221  NM_073290.2  NP_505691.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes --
    AQY16
    (see all 3)
    Putative protein; in the Sigma 1278B strain backgr...
    Spore-specific water channel that mediates the tra...
    (see all 3)
    26(a)
    21(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    XII(35503-35961) YLL053C
    XVI(921860-922777) YPR192W
    soybean
    (Glycine max)
    eudicotyledons 467510212   -- 79.35(n)  


    ENSEMBL Gene Tree for AQP8 (if available)
    TreeFam Gene Tree for AQP8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AQP8 gene
    ENSG000002504242  AQP22  MIP2  AQP52  AQP12  AQP42  AQP62  
    5 SIMAP similar genes for AQP8 using alignment to 2 protein entries:     AQP8_HUMAN (see all proteins):
    AQP5    AQP6    AQP1    MIP    AQP2

    Find genes that share paralogs with AQP8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AQP8 (see all 402)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364844
    A breast cancer sample4--see VAR_0364842 I M mis40--------
    rs74995781,2
    C,F,A,H--25226313(+) cagcaA/Tttgga 1 -- us2k111Minor allele frequency- T:0.47NA WA EA 378
    rs1410655071,2
    --25226410(+) ACAGGA/TAATCT 1 -- us2k10--------
    rs1856344511,2
    --25226416(+) AATCTA/GTACCC 1 -- us2k10--------
    rs1450261051,2
    --25226455(+) CCCCTC/TGGGCC 1 -- us2k10--------
    rs1387142161,2
    --25226460(+) CGGGCC/GGTGGA 1 -- us2k10--------
    rs1489641331,2
    --25226505(+) CTAGTC/TTAGGT 1 -- us2k10--------
    rs1436990201,2
    --25226508(+) GTCTAA/GGTACT 1 -- us2k10--------
    rs1481064111,2
    --25226518(+) TTCATA/GCAAGT 1 -- us2k10--------
    rs1901042491,2
    --25226533(+) TCAGAC/TACAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for AQP8 (25227052 - 25240261 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for AQP8:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668763CNV Deletion23128226
    nsv820298CNV Gain19587683

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AQP8
    DNA2.0 Custom Variant and Variant Library Synthesis for AQP8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603750    OMIM disorders: --

    2 diseases for AQP8:    
    About MalaCards
    oligohydramnios    polyhydramnios

    1 disease from the University of Copenhagen DISEASES database for AQP8:
    Oligohydramnios

    Find genes that share disorders with AQP8           About GenesLikeMe

    2 Novoseek inferred disease relationships for AQP8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colitis ulcerative 29.7 2 18467915 (1), 17461471 (1)
    inflammatory bowel diseases 27.6 2 18467915 (1), 15338270 (1)

    Genetic Association Database (GAD): AQP8
    Human Genome Epidemiology (HuGE) Navigator: AQP8 (1 document)

    Export disorders for AQP8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AQP8 gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with AQP8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional expression of human aquaporin8 cDNA and analysis of its gene. (PubMed id 9806845)1, 2, 3, 9 Koyama N....Marumo F. (Genomics 1998)
    2. Assignment of the aquaporin-8 water channel gene (AQP8) to human chromosome 16p12. (PubMed id 10393433)1, 3, 9 Viggiano L....Calamita G. (Cytogenet. Cell Genet. 1999)
    3. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. [Relationship between cyclic adenosine monophosphate and aquaporin 8 expression and distribution in human amnion-derived cells]. (PubMed id 19087520)1, 9 Li L. and Qi H.B. (Zhonghua Fu Chan Ke Za Zhi 2008)
    6. [Expression of aquaporin-8 and bcl-2 protein in human cervical carcinoma and their correlations]. (PubMed id 18788571)1, 9 Yao J.F....Shi Y.F. (Zhonghua Fu Chan Ke Za Zhi 2008)
    7. Knockdown of hepatocyte aquaporin-8 by RNA interference induces defective bile canalicular water transport. (PubMed id 18948439)1, 9 Larocca M.C....Marinelli R.A. (Am. J. Physiol. Gastrointest. Liver Physiol. 2009)
    8. [Expression of aquaporin 8 in human fetal membrane and placenta of idiopathic polyhydramnios]. (PubMed id 19563057)1, 9 Huang J. and Qi H.B. (Zhonghua Fu Chan Ke Za Zhi 2009)
    9. Expression of aquaporin 8 is diversely regulated by osmotic stress in amnion epithelial cells. (PubMed id 20144166)1, 9 Qi H....Huang J. (J. Obstet. Gynaecol. Res. 2009)
    10. Expression of aquaporin 8 and its up-regulation by cyclic adenosine monophosphate in human WISH cells. (PubMed id 12712100)1, 9 Wang S....Ross M.G. (Am. J. Obstet. Gynecol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 343 HGNC: 642 AceView: AQP8 Ensembl:ENSG00000103375 euGenes: HUgn343
    ECgene: AQP8 Kegg: 343 H-InvDB: AQP8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AQP8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for AQP8 gene:
    Search GeneIP for patents involving AQP8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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