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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AQP7 Gene

protein-coding   GIFtS: 62
GCID: GC09M033384

Aquaporin 7


(Previous symbol: AQP7L)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Aquaporin 71 2     GLYCQTL2
AQP7L1 2 3     aquaglyceroporin-72
Aquaporin Adipose2 3     aquaporin-72
AQP-72 3     Aquaglyceroporin-73
AQP92 3     Aquaporin-7-like3
AQPap2 3     

External Ids:    HGNC: 6401   Entrez Gene: 3642   Ensembl: ENSG000001652697   OMIM: 6029745   UniProtKB: O145203   

Export aliases for AQP7 gene to outside databases

Previous GC identifers: GC09M033697 GC09M033554 GC09M033374 GC09M033341


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AQP7 Gene:
Aquaporins/major intrinsic protein (MIP) are a family of water-selective membrane channels. Aquaporin 7 has
greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. Aquaporin 7 and AQP3 are at the same
chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. Aquaporin 7 facilitates water,
glycerol and urea transport. It may play an important role in sperm function. (provided by RefSeq, Jul 2008)

GeneCards Summary for AQP7 Gene: 
AQP7 (aquaporin 7) is a protein-coding gene. Diseases associated with AQP7 include meniere's disease, and menieres disease, and among its related super-pathways are Regulation of Water Balance by Renal Aquaporins and SLC-mediated transmembrane transport. GO annotations related to this gene include water channel activity and urea channel activity. An important paralog of this gene is AQP9.

UniProtKB/Swiss-Prot: AQP7_HUMAN, O14520
Function: Forms a channel for water and glycerol

Gene Wiki entry for AQP7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008413.18  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AQP7 gene promoter:
         COUP-TF1   NF-1   COUP   HNF-4alpha2   Tal-1beta   E47   HNF-4alpha1   COUP-TF   ZID   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAQP7 promoter sequence
   Search SABiosciences Chromatin IP Primers for AQP7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AQP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13

AQP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AQP7 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M033384:  view genomic region     (about GC identifiers)

Start:
33,384,765 bp from pter      End:
33,402,643 bp from pter
Size:
17,879 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AQP7_HUMAN, O14520 (See protein sequence)
Recommended Name: Aquaporin-7  
Size: 342 amino acids; 37232 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q5T5L9 Q8NHM3

Explore the universe of human proteins at neXtProt for AQP7: NX_O14520

Explore proteomics data for AQP7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O14520

  • AQP7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AQP7 Protein Expression
    REFSEQ proteins: NP_001161.1  
    ENSEMBL proteins: 
     ENSP00000412868   ENSP00000368821   ENSP00000297988   ENSP00000410138   ENSP00000368820  
     ENSP00000368817   ENSP00000396111   ENSP00000438860   ENSP00000439534   ENSP00000441619  
    Reactome Protein details: O14520
    Human Recombinant Protein Products for AQP7: 
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    Novus Biologicals AQP7 Protein
    Novus Biologicals AQP7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AQP7 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA18718702
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS9405233
    GO:0005911cell-cell junction IDA18718702
    GO:0016020membrane ----

    AQP7 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for AQP7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    AQP: Ion channels / Aquaporins

    IUPHAR Guide to PHARMACOLOGY protein family classification: AQP7 
    Aquaporins

    3 InterPro protein domains:
     IPR023271 Aquaporin-like
     IPR015686 Aquaporin_7
     IPR000425 MIP

    Graphical View of Domain Structure for InterPro Entry O14520

    ProtoNet protein and cluster: O14520

    1 Blocks protein domain: IPB000425 MIP family

    UniProtKB/Swiss-Prot: AQP7_HUMAN, O14520
    Domain: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming
    loop with the signature motif Asn-Pro/Ala-Ala/Ser (NPA)
    Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family


    AQP7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AQP7_HUMAN, O14520
    Function: Forms a channel for water and glycerol

         Genatlas biochemistry entry for AQP7:
    aquaporin 7,water channel forming integral protein,MIP family,expressed in the testis,putatively involved in the
    formation of late spermatids,also expressed in kidney

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0015250water channel activity TAS9405233
    GO:0015254glycerol channel activity EXP--
    GO:0015265urea channel activity IEA--
         
    AQP7 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for AQP7:
     Increased G2M DNA content  Increased number of mitotic ce 

         7 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Aqp7):
     adipose tissue  cellular  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     renal/urinary system  reproductive system 

    AQP7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for AQP7: Aqp7tm1.1Suc Aqp7tm1Ask Aqp7tm1Nlsn Aqp7tm1Tfun

       inGenious Targeting Laboratory - Custom generated mouse model solutions for AQP7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AQP7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AQP7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AQP7 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AQP7 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Regulation of Water Balance by Renal Aquaporins
    Aquaporin-mediated transport0.84
    2SLC-mediated transmembrane transport
    Transmembrane transport of small molecules0.50
    3Nanog in Mammalian ESC Pluripotency
    eNOS Signaling0.48
    4Transport of Glycerol from Adipocytes to the Liver by Aquaporins
    Transport of Glycerol from Adipocytes to the Liver by Aquaporins
    5Passive Transport by Aquaporins
    Passive Transport by Aquaporins

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for AQP7
        eNOS Signaling

    1 BioSystems Pathway for AQP7
        Integrated Breast Cancer Pathway

    4        Reactome Pathways for AQP7
        Transmembrane transport of small molecules
    Aquaporin-mediated transport
    Transport of Glycerol from Adipocytes to the Liver by Aquaporins
    Passive Transport by Aquaporins


    1         Kegg Pathway  (Kegg details for AQP7):
        PPAR signaling pathway


    AQP7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AQP7

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006091generation of precursor metabolites and energy TAS9405233
    GO:0006810transport ----
    GO:0006833water transport TAS--
    GO:0007283spermatogenesis IEA--
    GO:0007588excretion TAS9405233

    AQP7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AQP7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AQP7

    1 IUPHAR Ligand for AQP7 (AQP7)    About this table 
    LigandTypeActionAffinityPubmed IDs
    Hg2+
    InhibitorNone--

    2 Novoseek inferred chemical compound relationships for AQP7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycerol 69.9 34 17543220 (4), 16764946 (3), 16154425 (2), 11952783 (2) (see all 14)
    forskolin 19.6 1 12778365 (1)

    Search CenterWatch for drugs/clinical trials and news about AQP7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AQP7 gene: 
    NM_001170.1  

    Unigene Cluster for AQP7:

    Aquaporin 7
    Hs.455323  [show with all ESTs]
    Unigene Representative Sequence: BC119673
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447660 ENST00000379507 ENST00000297988(uc003zst.3 uc003zsu.1)
    ENST00000439678 ENST00000379506(uc010mjs.2 uc010mjt.2) ENST00000379503
    ENST00000377425 ENST00000541274 ENST00000539936(uc011lnx.1 uc011lny.1 uc003zss.3 uc011lnz.1 uc011loa.1)
    ENST00000537089
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AQP7

    Additional mRNA sequence: 

    AB006190.1 AK294028.1 AK297860.1 AK297885.1 AK300716.1 AK301949.1 AK310456.1 AK315879.1 
    BC062701.1 BC119672.1 BC119673.1 DQ786216.1 

    6 DOTS entries:

    DT.91690399  DT.121161469  DT.100754411  DT.100744066  DT.121161454  DT.121161461 

    24/64 AceView cDNA sequences (see all 64):

    AI565345 AA431575 CD610869 AI733526 F27435 R73044 F25129 CA427631 
    AW016640 NM_001170 BI763267 R47862 BG400737 CB270263 CD514760 T60397 
    CD610870 AI478534 BV205810 CD610865 AW779701 CD610863 AI247532 CD610866 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AQP7 expression in normal human tissues (normalized intensities)      AQP7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCTAGAGC
    AQP7 Expression
    About this image


    AQP7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 3 entries
             Visceral White Adipose
             epididymal fat pads   
     
     Breast (Uncategorized)
             MAMMARY GLAND   
     
     Testis (Reproductive System)
     
     Epidermis (Integumentary System)
     
     Dermis (Integumentary System)

    See AQP7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AQP7

    SOURCE GeneReport for Unigene cluster: Hs.455323
        SABiosciences Expression via Pathway-Focused PCR Arrays including AQP7: 
              Drug Transporters in human mouse rat
              PPAR Targets in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AQP7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for AQP7 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aqp71 , 5 aquaporin 71, 5 78.82(n)1
    77.26(a)1
      4 (20.83 cM)5
    118321  NM_007473.41  NP_031499.11 
     410330745 
    chicken
    (Gallus gallus)
    Aves AQP71 aquaporin 7 63.54(n)
    59.37(a)
      426892  XM_424498.3  XP_424498.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    53(a)
    37(a)
    1 ↔ many
    1 ↔ many
    GL343372.1(412706-434498)
    GL343859.1(47209-62391)
    zebrafish
    (Danio rerio)
    Actinopterygii aqp71 aquaporin 7 59.81(n)
    55.24(a)
      334529  NM_199910.2  NP_956204.2 
    worm
    (Caenorhabditis elegans)
    Secernentea Y69E1A.73 Major intrinsic protein 38(a)
    (best of 2)
      IV(10961471-10962477)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YFL054C6
    Putative channel-like protein; similar to Fps1p; m...
    15(a)
    1 → many
    VI(20847-22787)


    ENSEMBL Gene Tree for AQP7 (if available)
    TreeFam Gene Tree for AQP7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AQP7 gene
    AQP92  AQP102  AQP32  
    5 SIMAP similar genes for AQP7 using alignment to 10 protein entries:     AQP7_HUMAN (see all proteins):
    AQP7P3    bA251O17.3    AQP3    AQP9    AQP10

    AQP7 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for AQP7
    PGOHUM00000260507 PGOHUM00000260508 PGOHUM00000260514 PGOHUM00000260515


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: AQP7_HUMAN, O14520
    Polymorphism: Genetic variations in AQP7 are responsible for changes in glycerol release during exercise and
    define the glycerol quantitative trait locus (GLYCQTL) [MIM:614411]


    10/864 SNPs in AQP7 are shown (see all 864)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs625427431,2,4
    C,Funtested133354466(+) AGGCAC/ACCAGA 2 /G /V mis14Minor allele frequency- A:0.04NA EU 5957
    rs40086691,2
    C--33353677(+) TAGTAC/TATCTG 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs48796911,2
    C,F,A,H--33353683(+) ATCTGT/CGGTAT 1 -- ds50018Minor allele frequency- C:0.08NS EA NA WA 778
    rs40086701,2
    H--33353722(+) aatctA/Ggaaga 1 -- ds50014Minor allele frequency- G:0.00NS EA 380
    rs1812687771,2
    --33353730(+) AGAATA/GCTAGG 1 -- ds50010--------
    rs1121033261,2
    C--33353749(+) TAATG-/AAAAAA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs39549791,2
    C,H--33353777(+) TCTACA/CTTCTT 1 -- ds50014Minor allele frequency- C:0.00NS EA 408
    rs22476541,2
    C,F,H--33353794(+) TGCCTT/GGTCTG 1 -- ds500111Minor allele frequency- G:0.13NS EA NA CSA WA 768
    rs727074231,2
    C,F--33353810(+) AGAACC/TGGCCA 1 -- ds50011Minor allele frequency- T:0.03NA 120
    rs23809721,2
    H--33353822(+) AACTCA/GGGGAA 1 -- ds50014Minor allele frequency- G:0.00NS EA 398

    HapMap Linkage Disequilibrium report for AQP7 (33384765 - 33402643 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for AQP7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv8439CNV Loss18304495
    nsv482129CNV Gain20164927


    Human Gene Mutation Database (HGMD): AQP7
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing AQP7
    DNA2.0 Custom Variant and Variant Library Synthesis for AQP7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602974    OMIM disorders: --

    18 diseases for AQP7:    About MalaCards
    meniere's disease    menieres disease    endolymphatic hydrops    morbid obesity
    nephrogenic diabetes insipidus    constipation    diabetes insipidus    traumatic brain injury
    brain injury    obesity    insulin resistance    ulcerative colitis
    crohn's disease    pneumonia    atherosclerosis    hypoxia
    thyroiditis    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for AQP7:
    Nephrogenic diabetes insipidus     Endolymphatic hydrops

    AQP7 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    2 Novoseek inferred disease relationships for AQP7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 29.9 13 18401671 (2), 16764946 (2), 17566090 (2), 16046537 (1) (see all 6)
    insulin resistance 25.4 6 16154425 (1), 18401671 (1), 12778365 (1)

    Genetic Association Database (GAD): AQP7
    Human Genome Epidemiology (HuGE) Navigator: AQP7 (1 document)

    Export disorders for AQP7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AQP7 gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with AQP7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Adipose tissue expression of the glycerol channel aquaporin-7 gene is altered in severe obesity but not in type 2 diabetes. (PubMed id 17566090)1, 2, 9 Ceperuelo-Mallafre V....Vendrell J. (2007)
    2. Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation. (PubMed id 11952783)1, 2, 9 Kondo H....Matsuzawa Y. (2002)
    3. A functional variant of the adipocyte glycerol channel aquaporin 7 gene is associated with obesity and related metabolic abnormalities. (PubMed id 17351148)1, 4 Prudente S....Trischitta V. (2007)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    5. Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability. (PubMed id 9405233)1, 2 Kuriyama H.... Okubo K. (1997)
    6. Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea. (PubMed id 9252401)1, 3 Ishibashi K....Sasaki S. (1997)
    7. Gene expression of paired abdominal adipose AQP7 and liver AQP9 in patients with morbid obesity: relationship with glucose abnormali ties. (PubMed id 19615702)1, 9 Miranda M....Vendrell J. (2009)
    8. Influence of morbid obesity and insulin resistance on gene expression levels of AQP7 in visceral adipose tissue and AQP9 in liver. (PubMed id 18401671)1, 9 Catalan V....Fruhbeck G. (2008)
    9. Molecular characterization of human Aquaporin-7 gene and its chromosomal mapping. (PubMed id 9714739)1, 9 Ishibashi K....Sasaki S. (1998)
    10. Differential expression of aquaporin 7 in adipose tissue of lean and obese high fat consumers. (PubMed id 16325777)1, 9 Marrades M.P....Moreno-Aliaga M.J. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 364 HGNC: 640 AceView: AQP7 Ensembl:ENSG00000165269 euGenes: HUgn364
    ECgene: AQP7 Kegg: 364 H-InvDB: AQP7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AQP7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AQP7 gene:
    Search GeneIP for patents involving AQP7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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