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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AQP7 Gene

protein-coding   GIFtS: 59
GCID: GC09M033384

aquaporin 7


(Previous symbol: AQP7L)
 Explore 20 diseases affiliated with
AQP7 via our new
 Human Malady Compendium 
Biological research products
for AQP7
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Aquaporin 71 2     GLYCQTL2
AQP7L1 2 3     Aquaglyceroporin-73
AQP91 2 3     Aquaporin-71
AQPap1 2 3     Aquaglyceroporin-73
Aquaporin Adipose2 3     Aquaporin-7-Like1
AQP-72 3     

External Ids:    HGNC: 6401   Entrez Gene: 3642   Ensembl: ENSG000001652697   OMIM: 6029745   UniProtKB: O145203   

Export aliases for AQP7 gene to outside databases

Previous GC identifers: GC09M033697 GC09M033554 GC09M033374 GC09M033341


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AQP7:
Aquaporins/major intrinsic protein (MIP) are a family of water-selective membrane channels. Aquaporin 7 has greater
sequence similarity with AQP3 and AQP9 and they may be a subfamily. Aquaporin 7 and AQP3 are at the same chromosomal
location suggesting that 9p13 may be a site of an aquaporin cluster. Aquaporin 7 facilitates water, glycerol and urea
transport. It may play an important role in sperm function. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: AQP7_HUMAN, O14520
Function: Forms a channel for water and glycerol

Gene Wiki entry for AQP7


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AQP7 gene promoter:
         COUP-TF1   NF-1   COUP   HNF-4alpha2   Tal-1beta   E47   HNF-4alpha1   COUP-TF   ZID   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAQP7 promoter sequence
   Search SABiosciences Chromatin IP Primers for AQP7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AQP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13

AQP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AQP7 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M033384:  view genomic region     (about GC identifiers)

Start:
33,384,765 bp from pter      End:
33,402,643 bp from pter
Size:
17,879 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AQP7_HUMAN, O14520 (See protein sequence)
Recommended Name: Aquaporin-7  
Size: 342 amino acids; 37232 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q5T5L9 Q8NHM3

Explore the universe of human proteins at neXtProt for AQP7: NX_O14520

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O14520

  • AQP7 Protein expression data from MOPED and PaxDb:    About this image 
    AQP7 Protein Expression
    REFSEQ proteins: NP_001161.1  
    ENSEMBL proteins: 
     ENSP00000368821   ENSP00000412868   ENSP00000297988   ENSP00000410138   ENSP00000368820  
     ENSP00000368817   ENSP00000396111   ENSP00000438860   ENSP00000439534   ENSP00000441619  
    Reactome Protein details: O14520
    Human Recombinant Protein Products for AQP7: 
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    Novus Biologicals AQP7 Protein
    Novus Biologicals AQP7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for AQP7

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA18718702
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS9405233
    GO:0005911cell-cell junction IDA18718702
    GO:0016020membrane ----

    AQP7 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    AQP7 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR023271 Aquaporin-like
     IPR015686 Aquaporin_7
     IPR000425 MIP

    Graphical View of Domain Structure for InterPro Entry O14520

    ProtoNet protein and cluster: O14520

    1 Blocks protein family: IPB000425 MIP family

    UniProtKB/Swiss-Prot: AQP7_HUMAN, O14520
    Domain: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop
    with the signature motif Asn-Pro/Ala-Ala/Ser (NPA)
    Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AQP7_HUMAN, O14520
    Function: Forms a channel for water and glycerol

         Genatlas biochemistry entry for AQP7:
    aquaporin 7,water channel forming integral protein,MIP family,expressed in the testis,putatively involved in the
    formation of late spermatids,also expressed in kidney

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0015250water channel activity TAS9405233
    GO:0015254glycerol channel activity EXP--
    GO:0015265urea channel activity IEA--
         
    AQP7 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for AQP7:
     Increased G2M DNA content  Increased number of mitotic ce 

         7 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Aqp7):
     adipose tissue  cellular  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     renal/urinary system  reproductive system 

    AQP7 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for AQP7: Aqp7tm1.1Suc Aqp7tm1Ask Aqp7tm1Nlsn Aqp7tm1Tfun
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for AQP7 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AQP7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Passive Transport by Aquaporins
    Passive Transport by Aquaporins1.00
    2Transport of Glycerol from Adipocytes to the Liver by Aquaporins
    Transport of Glycerol from Adipocytes to the Liver by Aquaporins1.00
    3PPAR signaling pathway
    PPAR signaling pathway1.00
    4Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway1.00
    5Regulation of Water Balance by Renal Aquaporins
    Aquaporin-mediated transport0.84

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for AQP7
        eNOS Signaling

    1 BioSystems Pathway for AQP7 
        Integrated Breast Cancer Pathway

    4        Reactome Pathways for AQP7
        Transmembrane transport of small molecules
    Aquaporin-mediated transport
    Transport of Glycerol from Adipocytes to the Liver by Aquaporins
    Passive Transport by Aquaporins


    1         Kegg Pathway  (Kegg details for AQP7):
        PPAR signaling pathway


    AQP7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AQP7

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006091generation of precursor metabolites and energy TAS9405233
    GO:0006833water transport TAS--
    GO:0007283spermatogenesis IEA--
    GO:0007588excretion TAS9405233
    GO:0015793glycerol transport TAS--

    AQP7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AQP7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AQP7
    2 Novoseek chemical compound relationships for AQP7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycerol 69.9 34 17543220 (4), 16764946 (3), 16154425 (2), 11952783 (2) (see all 14)
    forskolin 19.6 1 12778365 (1)

    Search CenterWatch for drugs/clinical trials and news about AQP7 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AQP7 gene: 
    NM_001170.1  

    Unigene Cluster for AQP7:

    Aquaporin 7
    Hs.455323  [show with all ESTs]
    Unigene Representative Sequence: BC119673
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379507 ENST00000447660 ENST00000297988(uc003zst.3 uc003zsu.1)
    ENST00000481906 ENST00000439678 ENST00000379506(uc010mjs.2 uc010mjt.2)
    ENST00000379503 ENST00000377425 ENST00000541274 ENST00000539936(uc011lnx.1 uc011lny.1 uc003zss.3 uc011lnz.1 uc011loa.1)
    ENST00000537089

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    Additional cDNA sequence: 

    AB006190.1 AK294028.1 AK297860.1 AK297885.1 AK300716.1 AK301949.1 AK310456.1 AK315879.1 
    BC062701.1 BC119672.1 BC119673.1 DQ786216.1 

    6 DOTS entries:

    DT.91690399  DT.121161469  DT.100754411  DT.100744066  DT.121161454  DT.121161461 

    24/64 AceView cDNA sequences (see all 64):

    AW016640 F25129 CD610869 AA431575 R73044 AI565345 AI733526 CA427631 
    F27435 AI668576 AI732264 BX114491 CD610866 CD610870 R47862 CD514760 
    T60397 BE856499 AI820685 AB006190 AU133523 CB270263 BV205810 AI263210 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AQP7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCCTAGAGC
    AQP7 Expression
    About this image
    See AQP7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AQP7

    SOURCE GeneReport for Unigene cluster: Hs.455323
        SABiosciences Expression via Pathway-Focused PCR Arrays including AQP7: 

              Drug Transporters in human mouse rat
              PPAR Targets in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for AQP7 gene from 7/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves AQP71 aquaporin 7 63.54(n)
    59.37(a)
      426892  XM_424498.3  XP_424498.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    53(a)
    39(a)
    1 ↔ many
    1 ↔ many
    GL343372.1(420125-434137)
    GL343859.1(47209-60748)
    zebrafish
    (Danio rerio)
    Actinopterygii aqp71 aquaporin 7 59.81(n)
    55.24(a)
      334529  NM_199910.2  NP_956204.2 
    worm
    (Caenorhabditis elegans)
    Secernentea Y69E1A.73 Major intrinsic protein 38(a)
    (best of 2)
      IV(10961471-10962477)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NIP1;26
    NLM16
    (see all 9)
    aquaporin NIP1-1
    (see all 9)
    21(a)
    21(a)
    (see all 9)
    possible ortholog
    possible ortholog
    (see all 9)
    4(10366059-10368381)
    4(10421525-10423487)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 12)
    aquaporin protein, putative
    (see all 12)
    22(a)
    20(a)
    (see all 12)
    possible ortholog
    possible ortholog
    (see all 12)
    2(7515989-7519336)
    6(20959709-20960822)
    E. coli
    (Escherichia coli)
    Gamma proteobacteria glpF6
    glycerol facilitator
    30(a)
    possible ortholog
    Chromosome(4115268-4116113)


    ENSEMBL Gene Tree for AQP7 (if available)
    TreeFam Gene Tree for AQP7 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AQP7 gene
    AQP92  AQP102  AQP32  
    5 SIMAP similar genes for AQP7 using alignment to 10 protein entries:     AQP7_HUMAN (see all proteins):
    AQP7P3    bA251O17.3    AQP3    AQP9    AQP10

    AQP7 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for AQP7
    PGOHUM00000260507 PGOHUM00000260508 PGOHUM00000260514 PGOHUM00000260515


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: AQP7_HUMAN, O14520
    Polymorphism: Genetic variations in AQP7 are responsible for changes in glycerol release during exercise and define the
    glycerol quantitative trait locus (GLYCQTL) [MIM:614411]


    10/736 NCBI SNPs in AQP7 are shown (see all 736    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs625427431,2
    C,Fprobable-pathogenic33385241(+) AGGCAA/C/G/
            
    CCAGA
    4 D A G V mis14NA EU 5957
    rs48796911,2
    C,F,A,H--33384458(+) ATCTGT/CGGTAT 1 -- ds50018Minor allele frequency- C:0.08NS EA NA WA 778
    rs40086701,2
    H--33384497(+) aatctA/Ggaaga 1 -- ds50014Minor allele frequency- G:0.00NS EA 380
    rs1812687771,2
    --33384505(+) AGAATA/GCTAGG 1 -- ds50010--------
    rs1121033261,2
    C--33384524(+) TAATG-/AAAAAA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs39549791,2
    H--33384552(+) TCTACA/CTTCTT 1 -- ds50014Minor allele frequency- C:0.00NS EA 408
    rs22476541,2
    C,F,H--33384569(+) TGCCTT/GGTCTG 1 -- ds500111Minor allele frequency- G:0.13NS EA NA CSA WA 768
    rs727074231,2
    C,F--33384585(+) AGAACC/TGGCCA 1 -- ds50011Minor allele frequency- T:0.03NA 120
    rs23809721,2
    H--33384597(+) AACTCA/GGGGAA 1 -- ds50014Minor allele frequency- G:0.00NS EA 398
    rs734789551,2
    C,F--33384652(+) TCAAAG/TTATTT 1 -- ds50012Minor allele frequency- T:0.50WA CSA 4

    HapMap Linkage Disequilibrium report for AQP7 (33384765 - 33402643 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for AQP7
         7 CNVs: 82921 33088 82922 95936 95935 95937 82923
    Human Gene Mutation Database (HGMD): AQP7

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    AQP7 for disorders           About GeneDecksing

    OMIM gene information: 602974    OMIM disorders: --

    20 diseases for AQP7:    About MalaCards
    nephrogenic diabetes insipidus    endolymphatic hydrops    traumatic brain injury    diabetes insipidus
    brain injury    insulin resistance    meniere's disease    menieres disease
    morbid obesity    ulcerative colitis    constipation    obesity
    crohn's disease    conjunctivitis    atherosclerosis    pneumonia
    hypoxia    thyroiditis    malaria    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for AQP7:
    Nephrogenic diabetes insipidus     Endolymphatic hydrops

    2 Novoseek disease relationships for AQP7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 29.9 13 18401671 (2), 16764946 (2), 17566090 (2), 16046537 (1) (see all 6)
    insulin resistance 25.4 6 16154425 (1), 18401671 (1), 12778365 (1)

    Human Genome Epidemiology (HuGE) Navigator: AQP7 (1 document)

    Export disorders for AQP7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AQP7 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with AQP7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Adipose tissue expression of the glycerol channel aquaporin-7 gene is altered in severe obesity but not in type 2 diabetes. (PubMed id 17566090)1, 2, 9 Ceperuelo-Mallafre V....Vendrell J. (2007)
    2. Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation. (PubMed id 11952783)1, 2, 9 Kondo H....Matsuzawa Y. (2002)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    4. Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability. (PubMed id 9405233)1, 2 Kuriyama H.... Okubo K. (1997)
    5. Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea. (PubMed id 9252401)1, 3 Ishibashi K....Sasaki S. (1997)
    6. Gene expression of paired abdominal adipose AQP7 and liver AQP9 in patients with morbid obesity: relationship with glucose abnormali ties. (PubMed id 19615702)1, 9 Miranda M....Vendrell J. (2009)
    7. Influence of morbid obesity and insulin resistance on gene expression levels of AQP7 in visceral adipose tissue and AQP9 in liver. (PubMed id 18401671)1, 9 Catalan V....Fruhbeck G. (2008)
    8. Molecular characterization of human Aquaporin-7 gene and its chromosomal mapping. (PubMed id 9714739)1, 9 Ishibashi K....Sasaki S. (1998)
    9. Differential expression of aquaporin 7 in adipose tissue of lean and obese high fat consumers. (PubMed id 16325777)1, 9 Marrades M.P....Moreno-Aliaga M.J. (2006)
    10. Aquaporins (water channels): role in vasopressin-activated water transport. (PubMed id 9824541)1, 9 Dibas A.I....Yorio T. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 364 HGNC: 640 AceView: AQP7 Ensembl:ENSG00000165269 euGenes: HUgn364
    ECgene: AQP7 Kegg: 364 H-InvDB: AQP7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AQP7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AQP7 gene:
    Search GeneIP for patents involving AQP7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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