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Aliases for AQP7 Gene

Aliases for AQP7 Gene

  • Aquaporin 7 2 3
  • Aquaglyceroporin-7 3 4
  • Aquaporin Adipose 3 4
  • GLYCQTL 3 6
  • AQP7L 3 4
  • AQP-7 3 4
  • AQPap 3 4
  • AQP9 3 4
  • Aquaporin-7-Like 4
  • Aquaporin-7 3

External Ids for AQP7 Gene

Previous HGNC Symbols for AQP7 Gene

  • AQP7L

Previous GeneCards Identifiers for AQP7 Gene

  • GC09M033697
  • GC09M033554
  • GC09M033374
  • GC09M033341

Summaries for AQP7 Gene

Entrez Gene Summary for AQP7 Gene

  • Aquaporins/major intrinsic protein (MIP) are a family of water-selective membrane channels. Aquaporin 7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. Aquaporin 7 and AQP3 are at the same chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. Aquaporin 7 facilitates water, glycerol and urea transport. It may play an important role in sperm function. [provided by RefSeq, Jul 2008]

GeneCards Summary for AQP7 Gene

AQP7 (Aquaporin 7) is a Protein Coding gene. Diseases associated with AQP7 include endolymphatic hydrops and morbid obesity. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Integrated Breast Cancer Pathway. GO annotations related to this gene include water channel activity and urea channel activity. An important paralog of this gene is AQP10.

UniProtKB/Swiss-Prot for AQP7 Gene

  • Forms a channel for water and glycerol

Tocris Summary for AQP7 Gene

  • Aquaporins (AQPs)are integral membrane proteins that facilitate the transport of water across biological membranes along an osmotic gradient. There have been 13 AQP isoforms (AQP0-AQP12) identified in humans and rodents to date.

Gene Wiki entry for AQP7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AQP7 Gene

Genomics for AQP7 Gene

Regulatory Elements for AQP7 Gene

Genomic Location for AQP7 Gene

33,383,179 bp from pter
33,402,682 bp from pter
19,504 bases
Minus strand

Genomic View for AQP7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AQP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AQP7 Gene

Proteins for AQP7 Gene

  • Protein details for AQP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q08E94
    • Q5T5L9
    • Q8NHM3

    Protein attributes for AQP7 Gene

    342 amino acids
    Molecular mass:
    37232 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for AQP7 Gene


neXtProt entry for AQP7 Gene

Proteomics data for AQP7 Gene at MOPED

Post-translational modifications for AQP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for AQP7 Gene

Domains for AQP7 Gene

Gene Families for AQP7 Gene

  • AQP :Ion channels / Aquaporins

Protein Domains for AQP7 Gene


Graphical View of Domain Structure for InterPro Entry



  • O14520
  • Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro/Ala-Ala/Ser (NPA)
  • Belongs to the MIP/aquaporin (TC 1.A.8) family.
genes like me logo Genes that share domains with AQP7: view

Function for AQP7 Gene

Molecular function for AQP7 Gene

GENATLAS Biochemistry:
aquaporin 7,water channel forming integral protein,MIP family,expressed in the testis,putatively involved in the formation of late spermatids,also expressed in kidney
UniProtKB/Swiss-Prot Function:
Forms a channel for water and glycerol

Gene Ontology (GO) - Molecular Function for AQP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0015204 urea transmembrane transporter activity IBA --
GO:0015250 water channel activity TAS 9405233
GO:0015254 glycerol channel activity EXP --
genes like me logo Genes that share ontologies with AQP7: view
genes like me logo Genes that share phenotypes with AQP7: view

Animal Models for AQP7 Gene

MGI Knock Outs for AQP7:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AQP7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for AQP7 Gene

Localization for AQP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AQP7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for AQP7 Gene COMPARTMENTS Subcellular localization image for AQP7 gene
Compartment Confidence
plasma membrane 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for AQP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 18718702
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9405233
GO:0005911 cell-cell junction IDA 18718702
GO:0016020 membrane --
genes like me logo Genes that share ontologies with AQP7: view

Pathways for AQP7 Gene

genes like me logo Genes that share pathways with AQP7: view

Pathways by source for AQP7 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for AQP7 Gene

Gene Ontology (GO) - Biological Process for AQP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006091 generation of precursor metabolites and energy TAS 9405233
GO:0006810 transport --
GO:0006833 water transport TAS --
GO:0007588 excretion TAS 9405233
GO:0009992 cellular water homeostasis IBA --
genes like me logo Genes that share ontologies with AQP7: view

Compounds for AQP7 Gene

(1) IUPHAR Ligand for AQP7 Gene

Ligand Type Action Affinity Pubmed IDs
Hg2+ Inhibitor None

(2) Novoseek inferred chemical compound relationships for AQP7 Gene

Compound -log(P) Hits PubMed IDs
glycerol 69.9 25
forskolin 19.6 1
genes like me logo Genes that share compounds with AQP7: view

Transcripts for AQP7 Gene

Unigene Clusters for AQP7 Gene

Aquaporin 7:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AQP7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AQP7 Gene

No ASD Table

Relevant External Links for AQP7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AQP7 Gene

mRNA expression in normal human tissues for AQP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AQP7 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (12.2), Adipose - Subcutaneous (9.0), Heart - Left Ventricle (7.5), and Breast - Mammary Tissue (6.1).

Protein differential expression in normal tissues for AQP7 Gene

This gene is overexpressed in Testis (23.3), Fetal ovary (10.8), Urine (9.6), Heart (8.6), Fetal gut (6.9), and Ovary (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for AQP7 Gene

SOURCE GeneReport for Unigene cluster for AQP7 Gene Hs.455323

genes like me logo Genes that share expressions with AQP7: view

Expression partners for AQP7 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for AQP7 Gene

Orthologs for AQP7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AQP7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia AQP7 35
  • 78.05 (n)
  • 71.34 (a)
AQP7 36
  • 71 (a)
(Canis familiaris)
Mammalia AQP7 35
  • 80.65 (n)
  • 73.61 (a)
AQP7 36
  • 77 (a)
(Mus musculus)
Mammalia Aqp7 35
  • 78.45 (n)
  • 76.33 (a)
Aqp7 16
Aqp7 36
  • 73 (a)
(Rattus norvegicus)
Mammalia Aqp7 35
  • 79.29 (n)
  • 76.89 (a)
(Monodelphis domestica)
Mammalia AQP7 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia AQP7 36
  • 40 (a)
(Pan troglodytes)
Mammalia AQP7 36
  • 91 (a)
(Gallus gallus)
Aves AQP7 35
  • 63.29 (n)
  • 59.14 (a)
AQP7 36
  • 52 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
-- 36
  • 38 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia aqp7 35
  • 57.76 (n)
  • 54.15 (a)
(Danio rerio)
Actinopterygii aqp7 35
  • 59.81 (n)
  • 55.24 (a)
aqp7 36
  • 43 (a)
(Caenorhabditis elegans)
Secernentea M02F4.8 37
  • 36 (a)
Y69E1A.7 37
  • 38 (a)
aqp-1 36
  • 30 (a)
aqp-2 36
  • 36 (a)
aqp-3 36
  • 25 (a)
aqp-7 36
  • 31 (a)
aqp-8 36
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 17 (a)
Species with no ortholog for AQP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AQP7 Gene

Gene Tree for AQP7 (if available)
Gene Tree for AQP7 (if available)

Paralogs for AQP7 Gene

Paralogs for AQP7 Gene Pseudogenes for AQP7 Gene

genes like me logo Genes that share paralogs with AQP7: view

Variants for AQP7 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for AQP7 Gene

Genetic variations in AQP7 are responsible for changes in glycerol release during exercise and define the glycerol quantitative trait locus (GLYCQTL) [MIM:614411]

Sequence variations from dbSNP and Humsavar for AQP7 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs3569 -- 33,385,167(+) ACAGA(A/G)TCCTC synonymous-codon, reference, missense
rs13434 -- 33,384,979(-) CATCC(A/C)TTCCC utr-variant-3-prime
rs500278 -- 33,389,432(-) tctgg(A/G)aggct intron-variant
rs504770 -- 33,388,954(-) acttg(A/G)gccca intron-variant
rs556390 -- 33,397,292(-) CAAGG(A/G)AATCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AQP7 Gene

Variant ID Type Subtype PubMed ID
nsv8439 CNV Loss 18304495
nsv482129 CNV Gain 20164927

Relevant External Links for AQP7 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for AQP7 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for AQP7 Gene in MalaCards »

(5) Diseases for AQP7 Gene including...

(1) OMIM Diseases for AQP7 Gene (602974)

(2) University of Copenhagen DISEASES for AQP7 Gene

(2) Novoseek inferred disease relationships for AQP7 Gene

Disease -log(P) Hits PubMed IDs
obesity 29.9 9
insulin resistance 25.4 3

Relevant External Links for AQP7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with AQP7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AQP7 Gene

Publications for AQP7 Gene

  1. Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation. (PMID: 11952783) Kondo H. … Matsuzawa Y. (Eur. J. Biochem. 2002) 3 4 23
  2. Adipose tissue expression of the glycerol channel aquaporin-7 gene is altered in severe obesity but not in type 2 diabetes. (PMID: 17566090) Ceperuelo-Mallafre V. … Vendrell J. (J. Clin. Endocrinol. Metab. 2007) 3 4 23
  3. Gene expression of paired abdominal adipose AQP7 and liver AQP9 in patients with morbid obesity: relationship with glucose abnormalities. (PMID: 19615702) Miranda M. … Vendrell J. (Metab. Clin. Exp. 2009) 3 23
  4. Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea. (PMID: 9252401) Ishibashi K. … Sasaki S. (J. Biol. Chem. 1997) 2 3
  5. Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability. (PMID: 9405233) Kuriyama H. … Okubo K. (Biochem. Biophys. Res. Commun. 1997) 3 4

Products for AQP7 Gene

Sources for AQP7 Gene

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