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AQP6 Gene

protein-coding   GIFtS: 53
GCID: GC12P050417

Aquaporin 6, Kidney Specific


(Previous symbol: AQP2L)
  See AQP6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Aquaporin 6, Kidney Specific1 2     KID2
AQP2L1 2 3 5     Aquaporin 2-Like, Kidney Specific2
Kidney-Specific Aquaporin2 3     aquaporin-62
AQP-62 3     Aquaporin-6, Kidney Specific2
hKID2 3     Aquaporin-2-like3

External Ids:    HGNC: 6391   Entrez Gene: 3632   Ensembl: ENSG000000861597   OMIM: 6013835   UniProtKB: Q135203   

Export aliases for AQP6 gene to outside databases

Previous GC identifers: GC12P050655 GC12P050077 GC12P048647 GC12P047398


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AQP6 Gene:
The protein encoded by this gene is an aquaporin protein, which functions as a water channel in cells. Aquaporins
are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This
protein is specific for the kidney. This gene and related family members AQP0, AQP2, and AQP5 reside in a cluster
on chromosome 12q13. (provided by RefSeq, Jul 2008)

GeneCards Summary for AQP6 Gene:
AQP6 (aquaporin 6, kidney specific) is a protein-coding gene. Diseases associated with AQP6 include menieres disease, and meniere's disease. GO annotations related to this gene include water channel activity and nitrate transmembrane transporter activity. An important paralog of this gene is ENSG00000250424.

UniProtKB/Swiss-Prot: AQP6_HUMAN, Q13520
Function: Forms a water-specific channel that participates in distinct physiological functions such as glomerular
filtration, tubular endocytosis and acid-base metabolism (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AQP6 gene promoter:
         AML1a   p53   SREBP-1c   MyoD   LCR-F1   SREBP-1b   FOXL1   CP2   SREBP-1a   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAQP6 promoter sequence
   Search Chromatin IP Primers for AQP6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AQP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13

AQP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AQP6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P050417:  view genomic region     (about GC identifiers)

Start:
50,360,977 bp from pter      End:
50,370,922 bp from pter
Size:
9,946 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AQP6_HUMAN, Q13520 (See protein sequence)
Recommended Name: Aquaporin-6  
Size: 282 amino acids; 29370 Da
1 PDB 3D structure from and Proteopedia for AQP6:
1S6E (3D)    

Explore the universe of human proteins at neXtProt for AQP6: NX_Q13520

Explore proteomics data for AQP6 at MOPED


See AQP6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001643.2  
ENSEMBL proteins: 
 ENSP00000449830   ENSP00000320247  
Reactome Protein details: Q13520

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
AQP: Ion channels / Aquaporins

IUPHAR Guide to PHARMACOLOGY protein family classification: AQP6
Aquaporins

4 InterPro protein domains:
 IPR023271 Aquaporin-like
 IPR000425 MIP
 IPR022357 MIP_CS
 IPR023254 Aquaporin_6

Graphical View of Domain Structure for InterPro Entry Q13520

ProtoNet protein and cluster: Q13520

1 Blocks protein domain: IPB000425 MIP family

UniProtKB/Swiss-Prot: AQP6_HUMAN, Q13520
Domain: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming
loop with the signature motif Asn-Pro-Ala (NPA)
Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family


Find genes that share domains with AQP6           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: AQP6_HUMAN, Q13520
Function: Forms a water-specific channel that participates in distinct physiological functions such as glomerular
filtration, tubular endocytosis and acid-base metabolism (By similarity)

     Genatlas biochemistry entry for AQP6:
aquaporin 2-like,water channel forming integral protein,exclusively localized in intracellular membranes in renal
epithelial,located in intracellular membrane vesicles in glomeruli,in subapical compartment of segments 2 and 3
cells and in collecting ducts,potentially involved in glomerular filtration,tubular endocytosis and acid-base
metabolism

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005215transporter activity ----
GO:0005253anion channel activity EXP--
GO:0015112nitrate transmembrane transporter activity IEA--
GO:0015250water channel activity TAS8812490
     
Find genes that share ontologies with AQP6           About GenesLikeMe


Phenotypes:
     1 MGI mutant phenotype (inferred from 1 allele(MGI details for Aqp6):
 no phenotypic analysis 

Find genes that share phenotypes with AQP6           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Aqp6tm1Mysi for AQP6

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AQP6
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   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AQP6

miRNA
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
AQP6_HUMAN, Q13520: Cytoplasmic vesicle membrane; Multi-pass membrane protein (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane4

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005887integral component of plasma membrane TAS8812490
GO:0016020membrane ----
GO:0016021integral component of membrane ----
GO:0030658transport vesicle membrane TAS--

Find genes that share ontologies with AQP6           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for AQP6 About    
See pathways by source

SuperPathContained pathways About
1Regulation of Water Balance by Renal Aquaporins
Aquaporin-mediated transport0.85
Passive Transport by Aquaporins0.00
2Nanog in Mammalian ESC Pluripotency
eNOS Signaling0.48
3Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Transmembrane transport of small molecules0.47


Find genes that share SuperPaths with AQP6           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for AQP6
    eNOS Signaling

1 Reactome Pathway for AQP6
    Passive transport by Aquaporins


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AQP6
Interactions:

    Search GeneGlobe Interaction Network for AQP6

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for AQP6 (ENSP000003202474) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
DPYDENSP000003592114STRING: ENSP00000359211
FDXRENSP000002931954STRING: ENSP00000293195
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Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006810transport TAS8812490
GO:0006833water transport TAS--
GO:0007588excretion TAS8812490
GO:0015706nitrate transport ----
GO:0042476odontogenesis IEP12522663

Find genes that share ontologies with AQP6           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for AQP6

1 IUPHAR Ligand for AQP6 (AQP6)    About this table
LigandTypeActionAffinityPubmed IDs
Hg2+
InhibitorNone--

1 Novoseek inferred chemical compound relationship for AQP6 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
glycerol 43.9 1 17044001 (1)



Find genes that share compounds with AQP6           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for AQP6 gene (2 alternative transcripts): 
NM_001652.3  NM_053286.1  

Unigene Cluster for AQP6:

Aquaporin 6, kidney specific
Hs.54505  [show with all ESTs]
Unigene Representative Sequence: NM_001652
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000489786(uc001rvp.1 uc001rvq.1 uc001rvr.1) ENST00000551733
ENST00000315520
miRNA
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hsa-miR-1207-3p hsa-miR-4272 hsa-miR-608
SwitchGear 3'UTR luciferase reporter plasmidAQP6 3' UTR sequence
Inhib. RNA
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AQP6
Primer
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat AQP6
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  QuantiFast Probe-based Assays in human, mouse, rat AQP6

Additional mRNA sequence: 

BC065275.1 U48408.1 

3 DOTS entries:

DT.404461  DT.99942987  DT.75106831 

7 AceView cDNA sequences:

AL137716 BC065275 NM_053286 BU194843 AA872916 NM_001652 U48408 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for AQP6    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:              -           -                           
SP2:                    -     -                           
SP3:                                                      


ECgene alternative splicing isoforms for AQP6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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AQP6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACCTGGGTCA
AQP6 Expression
About this image


AQP6 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Neurons
         Glycinergic Amacrine Cells Inner Nuclear Layer
 
 Eye (Sensory Organs)
         Glycinergic Amacrine Cells Inner Nuclear Layer
 
 Brain (Nervous System)
         Cerebellum
AQP6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

AQP6 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.54505
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for AQP6 gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Aqp61 , 5 aquaporin 61, 5 80.34(n)1
77.66(a)1
  15 (56.13 cM)5
118311  NM_175087.41  NP_780296.11 
 996014005 
lizard
(Anolis carolinensis)
Reptilia AQP66
aquaporin 6, kidney specific
59(a)
1 ↔ 1
2(92281855-92303391)


ENSEMBL Gene Tree for AQP6 (if available)
TreeFam Gene Tree for AQP6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for AQP6 gene
ENSG000002504242  AQP82  AQP22  MIP2  AQP52  AQP12  AQP42  
7 SIMAP similar genes for AQP6 using alignment to 2 protein entries:     AQP6_HUMAN (see all proteins):
DKFZp434D2030    AQP5    AQP4    AQP2    MIP    AQP1
AQP8

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for AQP6 (see all 304)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1925317781,2
--50364656(+) AGACAC/TGCAGC 1 -- us2k10--------
rs1832436501,2
--50364658(+) ACACGC/TAGCAG 1 -- us2k10--------
rs1485427671,2
--50364667(+) AGGGAC/TGGGGT 1 -- us2k10--------
rs19963151,2
C,F,A,H--50364707(-) TCTTGC/TCAGCG 1 -- us2k125Minor allele frequency- T:0.39NS EA NA WA 2710
rs2967641,2
C,F,H--50364756(-) TCACCG/ATGTCC 1 -- us2k114Minor allele frequency- A:0.08NA WA CSA EA 378
rs782442281,2
C,F--50364766(+) AAGTCG/AAGACA 1 -- us2k11Minor allele frequency- A:0.01NA 120
rs2967651,2
C,F,H--50364898(+) CCCAGG/TTGGGG 1 -- us2k116Minor allele frequency- T:0.10NS EA NA WA CSA 661
rs1869422891,2
--50364940(+) GACATA/CGTCAT 1 -- us2k10--------
rs1428652181,2
--50365154(+) ATGCCC/TAGGTG 1 -- us2k10--------
rs1927034371,2
--50365378(+) TGAAGA/GCAGGC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for AQP6 (50360977 - 50370922 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for AQP6:    About this table    
Variant IDTypeSubtypePubMed ID
nsv832407CNV Loss17160897
nsv899072CNV Loss21882294
nsv522972CNV Gain19592680

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing AQP6
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 601383    OMIM disorders: --

2 diseases for AQP6:    
About MalaCards
menieres disease    meniere's disease

3 diseases from the University of Copenhagen DISEASES database for AQP6:
Nephrogenic diabetes insipidus     Diabetes insipidus     Meniere's disease

Find genes that share disorders with AQP6           About GenesLikeMe


Export disorders for AQP6 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for AQP6 gene, integrated from 10 sources (see all 19):
(articles sorted by number of sources associating them with AQP6)
    Utopia: connect your pdf to the dynamic
world of online information

  1. cDNA cloning and gene structure of a novel water channel expressed exclusively in human kidney: evidence for a gene cluster of aquaporins at chromosome locus 12q13. (PubMed id 8812490)1, 2, 3, 9 Ma T.... Verkman A.S. (Genomics 1996)
  2. Characterization of aquaporin-6 as a nitrate channel in mammalian cells. Requirement of pore-lining residue threonine 63. (PubMed id 12177001)1, 9 Ikeda M....Yasui M. (J. Biol. Chem. 2002)
  3. Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13. (PubMed id 9268644)1, 9 Ma T....Verkman A.S. (Genomics 1997)
  4. Immunohistochemical localization and mRNA expression of aquaporins in the macula utriculi of patients with Meniere's disease and acoustic neuroma. (PubMed id 20461409)1 Ishiyama G....Ishiyama A. (Cell Tissue Res. 2010)
  5. Gene expression profiling of chromophobe renal cell carcinomas and renal oncocytomas by Affymetrix GeneChip using pooled and individual tumours. (PubMed id 19680475)1 Yusenko M.V....Kovacs G. (Int. J. Biol. Sci. 2009)
  6. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)
  7. Aquaporin expression in developing human teeth and selected orofacial tissues. (PubMed id 12522663)1 Wang W....Hart T.C. (Calcif. Tissue Int. 2003)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  9. Conversion of aquaporin 6 from an anion channel to a water-selective channel by a single amino acid substitution. (PubMed id 15671159)9 Liu K....Yasui M. (Proc. Natl. Acad. Sci. U.S.A. 2005)
  10. pH regulated anion permeability of aquaporin-6. (PubMed id 19096784)9 Yasui M. (Handb Exp Pharmacol 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 363 HGNC: 639 AceView: AQP6 Ensembl:ENSG00000086159 euGenes: HUgn363
ECgene: AQP6 H-InvDB: AQP6

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for AQP6 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for AQP6 gene:
Search GeneIP for patents involving AQP6

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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