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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AQP6 Gene

protein-coding   GIFtS: 53
GCID: GC12P050417

Aquaporin 6, Kidney Specific


(Previous symbol: AQP2L)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Aquaporin 6, Kidney Specific1 2     KID2
AQP2L1 2 3 5     Aquaporin 2-Like, Kidney Specific2
Kidney-Specific Aquaporin2 3     aquaporin-62
AQP-62 3     Aquaporin-6, Kidney Specific2
hKID2 3     Aquaporin-2-like3

External Ids:    HGNC: 6391   Entrez Gene: 3632   Ensembl: ENSG000000861597   OMIM: 6013835   UniProtKB: Q135203   

Export aliases for AQP6 gene to outside databases

Previous GC identifers: GC12P050655 GC12P050077 GC12P048647 GC12P047398


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AQP6 Gene:
The protein encoded by this gene is an aquaporin protein, which functions as a water channel in cells. Aquaporins
are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This
protein is specific for the kidney. This gene and related family members AQP0, AQP2, and AQP5 reside in a cluster
on chromosome 12q13. (provided by RefSeq, Jul 2008)

GeneCards Summary for AQP6 Gene: 
AQP6 (aquaporin 6, kidney specific) is a protein-coding gene. Diseases associated with AQP6 include renal oncocytoma, and meniere's disease, and among its related super-pathways are Regulation of Water Balance by Renal Aquaporins and SLC-mediated transmembrane transport. GO annotations related to this gene include water channel activity and nitrate transmembrane transporter activity. An important paralog of this gene is ENSG00000250424.

UniProtKB/Swiss-Prot: AQP6_HUMAN, Q13520
Function: Forms a water-specific channel that participates in distinct physiological functions such as glomerular
filtration, tubular endocytosis and acid-base metabolism (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AQP6 gene promoter:
         AML1a   p53   SREBP-1c   MyoD   LCR-F1   SREBP-1b   FOXL1   CP2   SREBP-1a   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAQP6 promoter sequence
   Search SABiosciences Chromatin IP Primers for AQP6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AQP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13

AQP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AQP6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P050417:  view genomic region     (about GC identifiers)

Start:
50,360,977 bp from pter      End:
50,370,922 bp from pter
Size:
9,946 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AQP6_HUMAN, Q13520 (See protein sequence)
Recommended Name: Aquaporin-6  
Size: 282 amino acids; 29370 Da
Subcellular location: Cytoplasmic vesicle membrane; Multi-pass membrane protein (By similarity)
1 PDB 3D structure from and Proteopedia for AQP6:
1S6E (3D)    

Explore the universe of human proteins at neXtProt for AQP6: NX_Q13520

Explore proteomics data for AQP6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13520

  • AQP6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AQP6 Protein Expression
    REFSEQ proteins: NP_001643.2  
    ENSEMBL proteins: 
     ENSP00000449830   ENSP00000320247  
    Reactome Protein details: Q13520
    Human Recombinant Protein Products for AQP6: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AQP6 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS8812490
    GO:0016020membrane ----
    GO:0016021integral to membrane ----
    GO:0030658transport vesicle membrane TAS--

    AQP6 for ontologies           About GeneDecksing



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    Assay Products for AQP6: 
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    Cloud-Clone Corp. CLIAs for AQP6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    AQP: Ion channels / Aquaporins

    IUPHAR Guide to PHARMACOLOGY protein family classification: AQP6 
    Aquaporins

    4 InterPro protein domains:
     IPR022357 MIP_CS
     IPR023254 Aquaporin_6
     IPR023271 Aquaporin-like
     IPR000425 MIP

    Graphical View of Domain Structure for InterPro Entry Q13520

    ProtoNet protein and cluster: Q13520

    1 Blocks protein domain: IPB000425 MIP family

    UniProtKB/Swiss-Prot: AQP6_HUMAN, Q13520
    Domain: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming
    loop with the signature motif Asn-Pro-Ala (NPA)
    Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family


    AQP6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AQP6_HUMAN, Q13520
    Function: Forms a water-specific channel that participates in distinct physiological functions such as glomerular
    filtration, tubular endocytosis and acid-base metabolism (By similarity)

         Genatlas biochemistry entry for AQP6:
    aquaporin 2-like,water channel forming integral protein,exclusively localized in intracellular membranes in renal
    epithelial,located in intracellular membrane vesicles in glomeruli,in subapical compartment of segments 2 and 3
    cells and in collecting ducts,potentially involved in glomerular filtration,tubular endocytosis and acid-base
    metabolism

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005253anion channel activity EXP--
    GO:0015112nitrate transmembrane transporter activity IEA--
    GO:0015250water channel activity TAS8812490
         
    AQP6 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Aqp6):
     no phenotypic analysis 

    AQP6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Aqp6tm1Mysi for AQP6

       inGenious Targeting Laboratory - Custom generated mouse model solutions for AQP6 
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    SwitchGear 3'UTR luciferase reporter plasmidAQP6 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AQP6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of Water Balance by Renal Aquaporins
    Aquaporin-mediated transport0.84
    2SLC-mediated transmembrane transport
    Transmembrane transport of small molecules0.50
    3Nanog in Mammalian ESC Pluripotency
    eNOS Signaling0.48
    4Passive Transport by Aquaporins
    Passive Transport by Aquaporins

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for AQP6
        eNOS Signaling

    3        Reactome Pathways for AQP6
        Transmembrane transport of small molecules
    Aquaporin-mediated transport
    Passive Transport by Aquaporins



    AQP6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AQP6

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS8812490
    GO:0006833water transport TAS--
    GO:0007588excretion TAS8812490
    GO:0015706nitrate transport ----
    GO:0042476odontogenesis IEP12522663

    AQP6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AQP6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AQP6

    1 IUPHAR Ligand for AQP6 (AQP6)    About this table 
    LigandTypeActionAffinityPubmed IDs
    Hg2+
    InhibitorNone--

    1 Novoseek inferred chemical compound relationship for AQP6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycerol 43.9 1 17044001 (1)

    Search CenterWatch for drugs/clinical trials and news about AQP6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AQP6 gene (2 alternative transcripts): 
    NM_001652.3  NM_053286.1  

    Unigene Cluster for AQP6:

    Aquaporin 6, kidney specific
    Hs.54505  [show with all ESTs]
    Unigene Representative Sequence: NM_001652
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000489786(uc001rvp.1 uc001rvq.1 uc001rvr.1) ENST00000551733
    ENST00000315520
    miRNA
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    hsa-miR-1207-3p hsa-miR-4272 hsa-miR-608
    SwitchGear 3'UTR luciferase reporter plasmidAQP6 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    BC065275.1 U48408.1 

    3 DOTS entries:

    DT.404461  DT.99942987  DT.75106831 

    7 AceView cDNA sequences:

    BC065275 AL137716 NM_053286 BU194843 NM_001652 AA872916 U48408 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for AQP6    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:              -           -                           
    SP2:                    -     -                           
    SP3:                                                      


    ECgene alternative splicing isoforms for AQP6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AQP6 expression in normal human tissues (normalized intensities)      AQP6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTGGGTCA
    AQP6 Expression
    About this image


    AQP6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Eye (Sensory Organs)
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Brain (Nervous System)
             Cerebellum

    See AQP6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AQP6

    SOURCE GeneReport for Unigene cluster: Hs.54505
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AQP6 gene from 7/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aqp61 , 5 aquaporin 61, 5 80.22(n)1
    77.66(a)1
      15 (56.13 cM)5
    118311  NM_175087.41  NP_780296.11 
     996014005 
    chicken
    (Gallus gallus)
    Aves --
    --
    29(a)
    possible ortholog
    AADN03015245.1(1246-2676)
    lizard
    (Anolis carolinensis)
    Reptilia AQP66
    --
    --
    59(a)
    29(a)
    1 ↔ 1
    possible ortholog
    2(92281855-92303391)
    2(93186011-93195185)
    fruit fly
    (Drosophila melanogaster)
    Insecta bib6
    big brain
    12(a)
    1 → many
    2L(9984634-9995538)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YLL053C6
    AQY16
    (see all 3)
    Putative protein; in the Sigma 1278B strain backgr...
    Spore-specific water channel that mediates the tra...
    (see all 3)
    25(a)
    20(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    XII(35503-35961)
    XVI(921860-922777)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TIP4;11 aquaporin TIP4-1 48.88(n)
    41.83(a)
      817123  NM_128141.5  NP_180152.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g02320001 hypothetical protein 53.5(n)
    41.46(a)
      4324276  NM_001049035.2  NP_001042500.1 


    ENSEMBL Gene Tree for AQP6 (if available)
    TreeFam Gene Tree for AQP6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AQP6 gene
    ENSG000002504242  AQP82  AQP22  MIP2  AQP52  AQP12  AQP42  
    7 SIMAP similar genes for AQP6 using alignment to 2 protein entries:     AQP6_HUMAN (see all proteins):
    DKFZp434D2030    AQP5    AQP4    AQP2    MIP    AQP1
    AQP8

    AQP6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/304 SNPs in AQP6 are shown (see all 304)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1925317781,2
    --50364656(+) AGACAC/TGCAGC 1 -- us2k10--------
    rs1832436501,2
    --50364658(+) ACACGC/TAGCAG 1 -- us2k10--------
    rs1485427671,2
    --50364667(+) AGGGAC/TGGGGT 1 -- us2k10--------
    rs19963151,2
    C,F,A,H--50364707(-) TCTTGC/TCAGCG 1 -- us2k125Minor allele frequency- T:0.39NS EA NA WA 2710
    rs2967641,2
    C,F,H--50364756(-) TCACCG/ATGTCC 1 -- us2k114Minor allele frequency- A:0.08NA WA CSA EA 378
    rs782442281,2
    C,F--50364766(+) AAGTCG/AAGACA 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs2967651,2
    C,F,H--50364898(+) CCCAGG/TTGGGG 1 -- us2k116Minor allele frequency- T:0.10NS EA NA WA CSA 661
    rs1869422891,2
    --50364940(+) GACATA/CGTCAT 1 -- us2k10--------
    rs1428652181,2
    --50365154(+) ATGCCC/TAGGTG 1 -- us2k10--------
    rs1927034371,2
    --50365378(+) TGAAGA/GCAGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for AQP6 (50360977 - 50370922 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for AQP6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832407CNV Loss17160897
    nsv899072CNV Loss21882294
    nsv522972CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601383    OMIM disorders: --

    6 diseases for AQP6:    About MalaCards
    renal oncocytoma    meniere's disease    menieres disease    nephrogenic diabetes insipidus
    diabetes insipidus    neuroma

    3 diseases from the University of Copenhagen DISEASES database for AQP6:
    Nephrogenic diabetes insipidus     Diabetes insipidus     Meniere's disease

    AQP6 for disorders           About GeneDecksing


    Export disorders for AQP6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AQP6 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with AQP6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and gene structure of a novel water channel expressed exclusively in human kidney: evidence for a gene cluster of aquaporins at chromosome locus 12q13. (PubMed id 8812490)1, 2, 3, 9 Ma T.... Verkman A.S. (1996)
    2. Characterization of aquaporin-6 as a nitrate channel in mammalian cells. Requirement of pore-lining residue threonine 63. (PubMed id 12177001)1, 9 Ikeda M....Yasui M. (2002)
    3. Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13. (PubMed id 9268644)1, 9 Ma T....Verkman A.S. (1997)
    4. Immunohistochemical localization and mRNA expression of aquaporins in the macula utriculi of patients with Meniere's disease and aco ustic neuroma. (PubMed id 20461409)1 Ishiyama G....Ishiyama A. (2010)
    5. Gene expression profiling of chromophobe renal cell c arcinomas and renal oncocytomas by Affymetrix GeneChip using pooled and individ ual tumours. (PubMed id 19680475)1 Yusenko M.V....Kovacs G. (2009)
    6. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
    7. Aquaporin expression in developing human teeth and selected orofacial tissues. (PubMed id 12522663)1 Wang W....Hart T.C. (2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Conversion of aquaporin 6 from an anion channel to a water-selective channel by a single amino acid substitution. (PubMed id 15671159)9 Liu K....Yasui M. (2005)
    10. pH regulated anion permeability of aquaporin-6. (PubMed id 19096784)9 Yasui M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 363 HGNC: 639 AceView: AQP6 Ensembl:ENSG00000086159 euGenes: HUgn363
    ECgene: AQP6 H-InvDB: AQP6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AQP6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AQP6 gene:
    Search GeneIP for patents involving AQP6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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