Aliases for AQP5 Gene
External Ids for AQP5 Gene
- HGNC: 638
- Entrez Gene: 362
- Ensembl: ENSG00000161798
- OMIM: 600442
- UniProtKB: P55064
Previous GeneCards Identifiers for AQP5 Gene
- GC12P050649
- GC12P050411
- GC12P050072
- GC12P048641
- GC12P047386
Summaries for AQP5 Gene
-
Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. [provided by RefSeq, Jul 2008]
GeneCards Summary for AQP5 Gene
AQP5 (Aquaporin 5) is a Protein Coding gene. Diseases associated with AQP5 include Palmoplantar Keratoderma, Bothnian Type and Dry Eye Syndrome. Among its related pathways are Aquaporin-mediated transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity and glycerol channel activity. An important paralog of this gene is AQP2.
UniProtKB/Swiss-Prot for AQP5 Gene
-
Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity (PubMed:16571723). Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723).
-
Aquaporins (AQPs) are integral membrane proteins that facilitate the transport of water across biological membranes along an osmotic gradient. There have been 13 AQP isoforms (AQP0-AQP12) identified in humans and rodents to date.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AQP5 Gene
Genomics for AQP5 Gene
Regulatory Elements for AQP5 Gene
Enhancers for AQP5 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around AQP5 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for AQP5 Gene
- Chromosome:
- 12
- Start:
- 49,961,496 bp from pter
- End:
- 49,965,682 bp from pter
- Size:
- 4,187 bases
- Orientation:
- Plus strand
Genomic View for AQP5 Gene
Genes around AQP5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.12 by Ensembl
- 12q13.12 by Entrez Gene
- 12q13.12 by HGNC
AQP5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AQP5 Gene
Proteins for AQP5 Gene
-
Protein details for AQP5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P55064-AQP5_HUMAN
- Recommended name:
- Aquaporin-5
- Protein Accession:
- P55064
- Q6FGW8
Protein attributes for AQP5 Gene
- Size:
- 265 amino acids
- Molecular mass:
- 28292 Da
- Quaternary structure:
-
- Interacts with TRPV4; the interaction is probably indirect and regulates TRPV4 activation by hypotonicity.
Protein Expression for AQP5 Gene
Post-translational modifications for AQP5 Gene
Other Protein References for AQP5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for AQP5
-
Custom Antibody ServicesOriGene Antibodies for AQP5
- Novus Biologicals Antibodies for AQP5
- Invitrogen Antibodies for AQP5
- antibodies-online Antibodies for AQP5: See all 71
- GeneTex AQP5 antibody for AQP5
-
Santa Cruz Biotechnology (SCBT) Antibodies for AQP5
Protein Products
-
OriGene Purified Proteins for AQP5
- Search Origene for MassSpec and Protein Over-expression Lysates for AQP5
- Origene Custom Protein Services for AQP5
- Search GeneTex for Proteins for AQP5
No data available for DME Specific Peptides for AQP5 Gene
Domains & Families for AQP5 Gene
Gene Families for AQP5 Gene
- HGNC:
- IUPHAR :
Protein Domains for AQP5 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for AQP5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P55064UniProtKB/Swiss-Prot:
AQP5_HUMAN :- Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
- Belongs to the MIP/aquaporin (TC 1.A.8) family.
- Domain:
-
- Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
- Family:
-
- Belongs to the MIP/aquaporin (TC 1.A.8) family.
Function for AQP5 Gene
Molecular function for AQP5 Gene
- GENATLAS Biochemistry:
- aquaporin 5,water channel forming integral protein,expressed in salivary and lacrymal glands,cornea epithelium,lung,in apical but not in basal turn of the cochlea and putatively involved in low frequency hearing (MIP family)
- UniProtKB/Swiss-Prot Function:
- Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity (PubMed:16571723). Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0015250 | water channel activity | TAS,IDA | 12801959 |
Phenotypes for AQP5 Gene
- MGI mutant phenotypes for AQP5:
-
inferred from 3 alleles
- mortality/aging
- behavior/neurological phenotype
- growth/size/body region phenotype
- muscle phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for AQP5:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for AQP5
-
-
ViGene Biosciences lentiviral particle packaged cDNA for AQP5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AQP5 gene
- Search ViGene Biosciences for AQP5
CRISPR Products
-
OriGene CRISPR knockouts for AQP5
-
Santa Cruz Biotechnology (SCBT) CRISPR for AQP5
- GenScript: Design CRISPR guide RNA sequences for AQP5
miRNA for AQP5 Gene
- miRTarBase miRNAs that target AQP5
miRNA Products
- Search ViGene Biosciences for AQP5
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for AQP5
- Browse OriGene Inhibitory RNA Products For AQP5
-
ViGene Biosciences ready-to-package AAV shRNAs for AQP5 gene
Clone Products
- Sino Biological Human cDNA Clone for AQP5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for AQP5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AQP5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for AQP5
-
ViGene Biosciences adenoviral particle packaged cDNA for AQP5 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for AQP5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AQP5 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for AQP5 Gene
Localization for AQP5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for AQP5 Gene
- Apical cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 2 |
| nucleus | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 8621489 |
| GO:0005902 | microvillus | IEA | -- |
| GO:0009925 | basal plasma membrane | IEA | -- |
Pathways & Interactions for AQP5 Gene
Pathways by source for AQP5 Gene
1 BioSystems pathway for AQP5 Gene
3 Reactome pathways for AQP5 Gene
1 KEGG pathway for AQP5 Gene
1 Qiagen pathway for AQP5 Gene
Interacting Proteins for AQP5 Gene
Selected Interacting proteins:
P55064-AQP5_HUMAN
ENSP00000293599
for AQP5 Gene via
IID
STRING
MINT
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0006833 | water transport | TAS | -- |
| GO:0007588 | excretion | TAS | 8621489 |
| GO:0015670 | carbon dioxide transport | IDA | 19273840 |
| GO:0030157 | pancreatic juice secretion | IEP | 12801959 |
No data available for SIGNOR curated interactions for AQP5 Gene
Drugs & Compounds for AQP5 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Hg<sup>2+</sup> | Pharma | Inhibitor | 0 |
Transcripts for AQP5 Gene
mRNA/cDNA for AQP5 Gene
- (2) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (137) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for AQP5
-
Santa Cruz Biotechnology (SCBT) CRISPR for AQP5
- GenScript: Design CRISPR guide RNA sequences for AQP5
miRNA Products
- Search ViGene Biosciences for AQP5
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for AQP5
- Browse OriGene Inhibitory RNA Products For AQP5
-
ViGene Biosciences ready-to-package AAV shRNAs for AQP5 gene
Clone Products
- Sino Biological Human cDNA Clone for AQP5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for AQP5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AQP5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for AQP5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epithelial Cells
- Anterior Lens Epithelial Cells Lens
- Early Ameloblasts Dental Enamel
- Secondary Lens Fiber Cells Lens
- Type B cells Renal Collecting Duct System
- Inner Enamel Epithelial Cells Dental Enamel
-
Eye (Sensory Organs)
- Anterior Lens Epithelial Cells Lens
- Equatorial Lens Epithelial Cells Lens
- Transitional Lens Fiber Cells Lens
- Keratocytes Corneal Stroma
- Secondary Lens Fiber Cells Lens
-
Tooth (Integumentary System)
- Early Ameloblasts Dental Enamel
- Dental Papilla Cells Dental Papilla
- Odontoblasts Dentin
- Inner Enamel Epithelial Cells Dental Enamel
- Stellate Reticulum Cells Dental Core
- Lung (Respiratory System)
-
Fibroblasts
- Keratocytes Corneal Stroma
-
Kidney (Urinary System)
- Type B cells Renal Collecting Duct System
mRNA differential expression in normal tissues according to GTEx for AQP5 Gene
This gene is overexpressed in Testis (x17.3), Minor Salivary Gland (x10.9), Skin - Sun Exposed (Lower leg) (x9.4), and Skin - Not Sun Exposed (Suprapubic) (x7.3).
This gene is overexpressed in Nasal epithelium (66.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AQP5 Gene
NURSA nuclear receptor signaling pathways regulating expression of AQP5 Gene:
AQP5SOURCE GeneReport for Unigene cluster for AQP5 Gene:
Hs.298023Evidence on tissue expression from TISSUES for AQP5 Gene
- Eye(3.1)
- Lung(2.9)
- Nervous system(2.3)
- Saliva(2.2)
- Stomach(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for AQP5 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- cardiovascular
- immune
- integumentary
Organs:
Limb:
- foot
- hand
- lower limb
- upper limb
General:
- blood
- blood vessel
- skin
Primer Products
-
OriGene qPCR primer pairs for AQP5
-
OriGene qPCR primer pairs and template standards for AQP5
No data available for mRNA Expression by UniProt/SwissProt for AQP5 Gene
Orthologs for AQP5 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | AQP5 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | AQP5 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | AQP5 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Aqp5 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Aqp5 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | AQP5 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | AQP5 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | aqp5 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG7777 36 |
|
|
|
| soybean (Glycine max) |
eudicotyledons | Gma.12965 34 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.5652 34 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.14436 34 |
|
- Species where no ortholog for AQP5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for AQP5 Gene
Variants for AQP5 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs368292687 | Pathogenic, Keratoderma, palmoplantar, Bothnian type (PPKB) [MIM:600231] | 49,964,125(+) | CAGCC(C/T)GCTCT | upstream-variant-2KB, reference, missense | |
| rs398123054 | Pathogenic, Keratoderma, palmoplantar, Bothnian type (PPKB) [MIM:600231] | 49,962,130(+) | GTCGG(A/C/T)GCTGC | intron-variant, reference, missense | |
| rs398123055 | Pathogenic, Keratoderma, palmoplantar, Bothnian type (PPKB) [MIM:600231] | 49,962,151(+) | GCAGA(G/T)CGCGC | intron-variant, reference, missense | |
| rs398123056 | Pathogenic, Keratoderma, palmoplantar, Bothnian type (PPKB) [MIM:600231] | 49,964,092(+) | TCCAG(A/G/T)TCTAC | upstream-variant-2KB, reference, missense | |
| rs398123057 | Pathogenic, Keratoderma, palmoplantar, Bothnian type (PPKB) [MIM:600231] | 49,963,495(+) | AGCTC(A/G)ACAAC | upstream-variant-2KB, reference, missense |
Residual Variation Intolerance Score:
61.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.38;
27.29% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for AQP5 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AQP5 Gene
Disorders for AQP5 Gene
(14) MalaCards diseases for AQP5 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| palmoplantar keratoderma, bothnian type |
|
|
| dry eye syndrome |
|
|
| diffuse palmoplantar keratoderma, bothnian type |
|
|
| meniere's disease |
|
|
| diffuse pulmonary fibrosis |
|
|
Search AQP5 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
AQP5_HUMAN- Keratoderma, palmoplantar, Bothnian type (PPKB) [MIM:600231]: A dermatological disorder characterized by diffuse non-epidermolytic hyperkeratosis of the skin of palms and soles. PPKB is frequently complicated by fungal infections. {ECO:0000269 PubMed:23830519}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for AQP5
No data available for Genatlas for AQP5 Gene
Publications for AQP5 Gene
- The human aquaporin-5 gene. Molecular characterization and chromosomal localization. (PMID: 8621489) Lee M.D. … Agre P. (J. Biol. Chem. 1996) 2 3 4 22 64
- Mutations in AQP5, encoding a water-channel protein, cause autosomal-dominant diffuse nonepidermolytic palmoplantar keratoderma. (PMID: 23830519) Blaydon D.C. … Kelsell D.P. (Am. J. Hum. Genet. 2013) 2 3 4 64
- A novel-1364A/C aquaporin 5 gene promoter polymorphism influences the responses to salt loading of the renin-angiotensin-aldosterone system and of blood pressure in young healthy men. (PMID: 18846354) Adamzik M. … Siffert W. (Basic Res. Cardiol. 2008) 3 22 46 64
- Polymorphisms of aquaporin5 gene in chronic obstructive pulmonary disease in a Chinese population. (PMID: 18853286) Ning Y. … Wen F. (Swiss Med Wkly 2008) 3 22 46 64
- Expression profile of multiple aquaporins in human gastric carcinoma and its clinical significance. (PMID: 20106632) Shen L. … Wu W. (Biomed. Pharmacother. 2010) 3 22 64
Products for AQP5 Gene
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- Browse R&D Systems for biochemical assays
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- Custom Antibody ServicesOriGene Antibodies for AQP5
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- OriGene Purified Proteins for AQP5
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- OriGene qPCR primer pairs and template standards for AQP5
- OriGene qPCR primer pairs for AQP5
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- GenScript: Design CRISPR guide RNA sequences for AQP5
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- CloneReady with Over 120,000 Genes
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- Sino Biological Human cDNA Clone for AQP5
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- Novus Biologicals Antibodies for AQP5
- Novus Biologicals proteins and lysates for AQP5
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Cloud-Clone Corp Assay Kits for AQP5
- antibodies-online Antibodies for AQP5: See all 71
- antibodies-online Kits for AQP5: See all 47
- Search antibodies-online for proteins
- Search antibodies-online for peptides
- GeneTex AQP5 antibody for AQP5
- Search GeneTex for Proteins for AQP5
- ViGene Biosciences adenoviral particle packaged cDNA for AQP5 gene
- ViGene Biosciences lentiviral particle packaged cDNA for AQP5 gene
- ViGene Biosciences ready-to-package AAV shRNAs for AQP5 gene
- Search ViGene Biosciences for AQP5
- Santa Cruz Biotechnology (SCBT) Antibodies for AQP5
- Search Santa Cruz Biotechnology (SCBT) for AQP5 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for AQP5
- Horizon Cell Lines for AQP5
- Cyagen custom Knockout/knockin (KOKI) mouse models for AQP5
- VectorBuilder custom plasmid, inducible vectors for AQP5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AQP5
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for AQP5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
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