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AQP5 Gene

protein-coding   GIFtS: 66
GCID: GC12P050411

Aquaporin 5

  See AQP5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Aquaporin 51 2
AQP-52 3
PPKB2 5
aquaporin-52

External Ids:    HGNC: 6381   Entrez Gene: 3622   Ensembl: ENSG000001617987   OMIM: 6004425   UniProtKB: P550643   

Export aliases for AQP5 gene to outside databases

Previous GC identifers: GC12P050649 GC12P050072 GC12P048641 GC12P047386


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AQP5 Gene:
Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related
to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and
pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. (provided by RefSeq,
Jul 2008)

GeneCards Summary for AQP5 Gene:
AQP5 (aquaporin 5) is a protein-coding gene. Diseases associated with AQP5 include dry eye syndrome, and diffuse palmoplantar keratoderma, bothnian type. GO annotations related to this gene include water channel activity. An important paralog of this gene is ENSG00000250424.

UniProtKB/Swiss-Prot: AQP5_HUMAN, P55064
Function: Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions

Gene Wiki entry for AQP5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AQP5 gene promoter:
         HOXA9   C/EBPbeta   CP2   Sp1   p53   MyoD   LCR-F1   Pax-4a   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAQP5 promoter sequence
   Search Chromatin IP Primers for AQP5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AQP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13

AQP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AQP5 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P050411:  view genomic region     (about GC identifiers)

Start:
50,355,279 bp from pter      End:
50,359,464 bp from pter
Size:
4,186 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AQP5_HUMAN, P55064 (See protein sequence)
Recommended Name: Aquaporin-5  
Size: 265 amino acids; 28292 Da
1 PDB 3D structure from and Proteopedia for AQP5:
3D9S (3D)    
Secondary accessions: Q6FGW8

Explore the universe of human proteins at neXtProt for AQP5: NX_P55064

Post-translational modifications: 

  • Glycosylation2 at Asn124, Asn125
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins: NP_001642.1  
    ENSEMBL proteins: 
     ENSP00000293599  
    Reactome Protein details: P55064

    AQP5 Human Recombinant Protein Products:

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    antibodies-online antibodies for AQP5 (55 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AQP: Ion channels / Aquaporins

    IUPHAR Guide to PHARMACOLOGY protein family classification: AQP5
    Aquaporins

    4 InterPro protein domains:
     IPR023271 Aquaporin-like
     IPR023276 Aquaporin_5
     IPR000425 MIP
     IPR022357 MIP_CS

    Graphical View of Domain Structure for InterPro Entry P55064

    ProtoNet protein and cluster: P55064

    1 Blocks protein domain: IPB000425 MIP family

    UniProtKB/Swiss-Prot: AQP5_HUMAN, P55064
    Domain: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming
    loop with the signature motif Asn-Pro-Ala (NPA)
    Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family


    Find genes that share domains with AQP5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AQP5_HUMAN, P55064
    Function: Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions

         Genatlas biochemistry entry for AQP5:
    aquaporin 5,water channel forming integral protein,expressed in salivary and lacrymal glands,cornea
    epithelium,lung,in apical but not in basal turn of the cochlea and putatively involved in low frequency hearing
    (MIP family)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005515protein binding IPI16189514
    GO:0015250water channel activity IDA12801959
         
    Find genes that share ontologies with AQP5           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for AQP5:
     Decreased Wnt reporter activit  Increased TP53 protein express 

         11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Aqp5):
     behavior/neurological  digestive/alimentary  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear 
     homeostasis/metabolism  mortality/aging  muscle  no phenotypic analysis  respiratory system 
     vision/eye 

    Find genes that share phenotypes with AQP5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for AQP5: Aqp5tm1Ask Aqp5tm1Amn

       genOway: Develop your customized and physiologically relevant rodent model for AQP5

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    hsa-miR-21* hsa-miR-1226 hsa-miR-185* hsa-miR-634 hsa-miR-3921
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AQP5_HUMAN, P55064: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum2
    cytoskeleton1
    extracellular1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8621489
    GO:0005902microvillus IEA--
    GO:0009925basal plasma membrane IEA--

    Find genes that share ontologies with AQP5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AQP5 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Regulation of Water Balance by Renal Aquaporins
    Aquaporin-mediated transport0.85
    Passive Transport by Aquaporins0.00
    2Nanog in Mammalian ESC Pluripotency
    eNOS Signaling0.48
    3Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    4Salivary secretion
    Salivary secretion0.34
    5Stabilization and expansion of the E-cadherin adherens junction
    Stabilization and expansion of the E-cadherin adherens junction


    Find genes that share SuperPaths with AQP5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for AQP5
        eNOS Signaling

    1 BioSystems Pathway for AQP5
        Stabilization and expansion of the E-cadherin adherens junction


    1 Reactome Pathway for AQP5
        Passive transport by Aquaporins


    1 Kegg Pathway  (Kegg details for AQP5):
        Salivary secretion

        Pathway & Disease-focused RT2 Profiler PCR Array including AQP5: 
              Osmotic Stress in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for AQP5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for AQP5 (P550641, 2, 3 ENSP000002935994) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDFIQ997501, 2, 3, ENSP000002303214EBI-746103,EBI-724076 MINT-66783 I2D: score=5 STRING: ENSP00000230321
    CREB3O438893I2D: score=1 
    STX4ENSP000003177144STRING: ENSP00000317714
    EXOC3ENSP000003233774STRING: ENSP00000323377
    EXOC4ENSP000002538614STRING: ENSP00000253861
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006833water transport TAS--
    GO:0007588excretion TAS8621489
    GO:0015670carbon dioxide transport IDA19273840
    GO:0030157pancreatic juice secretion IEP12801959

    Find genes that share ontologies with AQP5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AQP5

    1 IUPHAR Ligand for AQP5 (AQP5)    About this table
    LigandTypeActionAffinityPubmed IDs
    Hg2+
    InhibitorNone--

    4 Novoseek inferred chemical compound relationships for AQP5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pilocarpine 39.6 2 11773623 (1), 16949105 (1)
    glycerol 13.3 1 17044001 (1)
    calcium 0 3 16537379 (1), 10600522 (1)
    estrogen 0 1 14635794 (1)



    Find genes that share compounds with AQP5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AQP5 gene: 
    NM_001651.3  

    Unigene Cluster for AQP5:

    Aquaporin 5
    Hs.298023  [show with all ESTs]
    Unigene Representative Sequence: NM_001651
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000293599(uc001rvo.2) ENST00000553132
    miRNA
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    Additional mRNA sequence: 

    BC032946.1 CR541989.1 CR542022.1 

    4 DOTS entries:

    DT.212199  DT.100668789  DT.91759665  DT.75101265 

    Selected AceView cDNA sequences (see all 137):

    BM850948 CD676386 BU738309 AI738904 AI963257 BU735096 BI828672 AA382090 
    BF439120 CR541989 BM695989 AI884587 CK431171 BM795210 BM712412 BM705754 
    BM706385 BG696199 BM785545 BM850852 AI690680 CD676193 CR601707 BM790056 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AQP5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGTGGGGCTG
    AQP5 Expression
    About this image


    AQP5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Epithelial Cells
             Alveolar Epithelial Type 1 Cells Alveoli
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Alveolar Epithelial Type 1 Cells Alveoli
             Lung epithelial-like cells
     
     Tooth (Integumentary System)    fully expand to see all 6 entries
             Odontoblasts Dentin
     
     Eye (Sensory Organs)    fully expand to see all 6 entries
             Secondary Lens Fiber Cells Lens
     
     Fibroblasts
             Keratocytes Corneal Stroma
    AQP5 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.298023
        Pathway & Disease-focused RT2 Profiler PCR Array including AQP5: 
              Osmotic Stress in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AQP5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aqp51 , 5 aquaporin 51, 5 86.16(n)1
    90.57(a)1
      15 (56.13 cM)5
    118301  NM_009701.41  NP_033831.11 
     995910285 
    chicken
    (Gallus gallus)
    Aves AQP51 aquaporin 5 77.19(n)
    76.05(a)
      431305  XM_001231780.3  XP_001231781.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    75(a)
    75(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    2(96166576-96172077)
    GL344577.1(1580-8200)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia aqp51 aquaporin 5 63.13(n)
    67.05(a)
      100491662  XM_002935743.1  XP_002935789.1 
    soybean
    (Glycine max)
    eudicotyledons Gma.129652 Transcribed sequence with moderate similarity to protein more 76.23(n)  
    corn
    (Zea mays)
    Liliopsida Zm.144362 Zea mays plasma membrane integral protein ZmPIP2-1 more 74.91(n)    AF326491.1 


    ENSEMBL Gene Tree for AQP5 (if available)
    TreeFam Gene Tree for AQP5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AQP5 gene
    ENSG000002504242  AQP82  AQP22  MIP2  AQP12  AQP42  AQP62  
    7 SIMAP similar genes for AQP5 using alignment to 1 protein entry:     AQP5_HUMAN:
    AQP6    AQP2    MIP    DKFZp434D2030    AQP4    AQP1
    AQP8

    Find genes that share paralogs with AQP5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AQP5 (see all 241)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0704424
    Keratoderma, palmoplantar, Bothnian type (PPKB)4--see VAR_0704422 A E mis40--------
    VAR_0704444
    Keratoderma, palmoplantar, Bothnian type (PPKB)4--see VAR_0704442 N D mis40--------
    VAR_0704434
    Keratoderma, palmoplantar, Bothnian type (PPKB)4--see VAR_0704432 I S mis40--------
    VAR_0704464
    Keratoderma, palmoplantar, Bothnian type (PPKB)4--see VAR_0704462 R C mis40--------
    VAR_0704454
    Keratoderma, palmoplantar, Bothnian type (PPKB)4--see VAR_0704452 I F mis40--------
    rs19646761,2
    C,F,A,H--50192804(-) TGGAAT/CGTGAG 1 -- ut3115Minor allele frequency- C:0.45NA WA CSA EA NS 3194
    rs1869151421,2
    --50353506(+) CCCCAA/GTGGCC 1 -- us2k10--------
    rs1415982771,2
    C--50353598(+) CATGAC/TTGGCT 1 -- us2k10--------
    rs1504822971,2
    --50354148(+) GAGAGA/GGTGGT 1 -- us2k10--------
    rs1922280391,2
    --50354267(+) GAGACC/TGAGAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for AQP5 (50355279 - 50359464 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for AQP5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832407CNV Loss17160897
    nsv899073CNV Loss21882294
    nsv899074CNV Loss21882294
    nsv899072CNV Loss21882294
    esv27744CNV Loss19812545
    nsv523899CNV Loss19592680
    nsv522972CNV Gain19592680

    Human Gene Mutation Database (HGMD): AQP5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AQP5
    DNA2.0 Custom Variant and Variant Library Synthesis for AQP5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600442   
    OMIM disorders: 600231  
    UniProtKB/Swiss-Prot: AQP5_HUMAN, P55064
  • Keratoderma, palmoplantar, Bothnian type (PPKB) [MIM:600231]: A dermatological disorder characterized by
    diffuse non-epidermolytic hyperkeratosis of the skin of palms and soles. PPKB is frequently complicated by fungal
    infections. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 11 diseases for AQP5:    
    About MalaCards
    dry eye syndrome    diffuse palmoplantar keratoderma, bothnian type    wrinkles    palmoplantar keratoderma, bothnia type
    congenital diaphragmatic hernia    meniere's disease    adenoid cystic carcinoma    pterygium
    nonepidermolytic palmoplantar keratoderma    idiopathic pulmonary fibrosis    alzheimer's disease

    2 diseases from the University of Copenhagen DISEASES database for AQP5:
    Respiratory failure     Sjogren's syndrome

    Find genes that share disorders with AQP5           About GenesLikeMe

    7 Novoseek inferred disease relationships for AQP5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    xerostomia 58.2 3 11232635 (1), 10476940 (1), 15640830 (1)
    sjogrens syndrome 55.1 12 11247557 (3), 15640830 (2), 15940770 (2), 11232635 (1) (see all 6)
    dry eye syndromes 51.9 1 11247557 (1)
    nasal polyps 47.1 27 19166033 (7), 15938209 (5), 15715403 (2)
    asthma 0 5 18647319 (3), 11707570 (1)
    tumors 0 8 16242760 (5), 18478076 (1)
    cystic fibrosis 0 1 12801959 (1)

    Genetic Association Database (GAD): AQP5
    Human Genome Epidemiology (HuGE) Navigator: AQP5 (5 documents)

    Export disorders for AQP5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AQP5 gene, integrated from 10 sources (see all 144):
    (articles sorted by number of sources associating them with AQP5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human aquaporin-5 gene. Molecular characterization and chromosomal localization. (PubMed id 8621489)1, 2, 3, 9 Lee M.D.... Agre P. (J. Biol. Chem. 1996)
    2. Mutations in AQP5, encoding a water-channel protein, cause autosomal-dominant diffuse nonepidermolytic palmoplantar keratoderma. (PubMed id 23830519)1, 2, 3 Blaydon D.C....Kelsell D.P. (Am. J. Hum. Genet. 2013)
    3. A novel-1364A/C aquaporin 5 gene promoter polymorphism influences the responses to salt loading of the renin-angiotensin-aldosterone system and of blood pressure in young healthy men. (PubMed id 18846354)1, 4, 9 Adamzik M....Siffert W. (Basic Res. Cardiol. 2008)
    4. Polymorphisms of aquaporin5 gene in chronic obstructive pulmonary disease in a Chinese population. (PubMed id 18853286)1, 4, 9 Ning Y....Wen F. (Swiss Med Wkly 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Expression of aquaporin 5 (AQP5) promotes tumor invasion in human non small cell lung cancer. (PubMed id 18478076)1, 9 Chae Y.K....Moon C. (PLoS ONE 2008)
    7. Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions. (PubMed id 16537379)1, 9 Sidhaye V.K....King L.S. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    8. Membrane trafficking of AQP5 and cAMP dependent phosphorylation in bronchial epithelium. (PubMed id 18042467)1, 9 Woo J....Moon C. (Biochem. Biophys. Res. Commun. 2008)
    9. Human AQP5 plays a role in the progression of chronic myelogenous leukemia (CML). (PubMed id 18612408)1, 9 Chae Y.K....Moon C. (PLoS ONE 2008)
    10. Comparative expression analysis of aquaporin-5 (AQP5) in keratoconic and healthy corneas. (PubMed id 18449356)1, 9 Garfias Y....Zenteno J.C. (Mol. Vis. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 362 HGNC: 638 AceView: AQP5 Ensembl:ENSG00000161798 euGenes: HUgn362
    ECgene: AQP5 Kegg: 362 H-InvDB: AQP5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for AQP5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for AQP5 gene:
    Search GeneIP for patents involving AQP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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