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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

AQP5 Gene

protein-coding   GIFtS: 64
GCID: GC12P050411

Aquaporin 5

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Aquaporin 51 2
AQP-52 3
aquaporin-52

External Ids:    HGNC: 6381   Entrez Gene: 3622   Ensembl: ENSG000001617987   OMIM: 6004425   UniProtKB: P550643   

Export aliases for AQP5 gene to outside databases

Previous GC identifers: GC12P050649 GC12P050072 GC12P048641 GC12P047386


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for AQP5 Gene:
Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related
to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and
pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. (provided by RefSeq,
Jul 2008)

GeneCards Summary for AQP5 Gene: 
AQP5 (aquaporin 5) is a protein-coding gene. Diseases associated with AQP5 include dry eye syndrome, and excessive tearing, and among its related super-pathways are Regulation of Water Balance by Renal Aquaporins and SLC-mediated transmembrane transport. GO annotations related to this gene include water channel activity and protein binding. An important paralog of this gene is ENSG00000250424.

UniProtKB/Swiss-Prot: AQP5_HUMAN, P55064
Function: Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions

Gene Wiki entry for AQP5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the AQP5 gene promoter:
         HOXA9   C/EBPbeta   CP2   Sp1   p53   MyoD   LCR-F1   Pax-4a   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAQP5 promoter sequence
   Search SABiosciences Chromatin IP Primers for AQP5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AQP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13

AQP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AQP5 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P050411:  view genomic region     (about GC identifiers)

Start:
50,355,279 bp from pter      End:
50,359,464 bp from pter
Size:
4,186 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AQP5_HUMAN, P55064 (See protein sequence)
Recommended Name: Aquaporin-5  
Size: 265 amino acids; 28292 Da
Subcellular location: Membrane; Multi-pass membrane protein
1 PDB 3D structure from and Proteopedia for AQP5:
3D9S (3D)    
Secondary accessions: Q6FGW8

Explore the universe of human proteins at neXtProt for AQP5: NX_P55064

Explore proteomics data for AQP5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P55064

  • AQP5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    AQP5 Protein Expression
    REFSEQ proteins: NP_001642.1  
    ENSEMBL proteins: 
     ENSP00000293599  
    Reactome Protein details: P55064
    Human Recombinant Protein Products for AQP5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for AQP5
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for AQP5
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    Novus Biologicals AQP5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for AQP5 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8621489
    GO:0005902microvillus IEA--
    GO:0009925basal plasma membrane IEA--

    AQP5 for ontologies           About GeneDecksing



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    Assay Products for AQP5: 
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    Cloud-Clone Corp. ELISAs for AQP5 
    Cloud-Clone Corp. CLIAs for AQP5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    AQP: Ion channels / Aquaporins

    IUPHAR Guide to PHARMACOLOGY protein family classification: AQP5 
    Aquaporins

    4 InterPro protein domains:
     IPR022357 MIP_CS
     IPR023271 Aquaporin-like
     IPR023276 Aquaporin_5
     IPR000425 MIP

    Graphical View of Domain Structure for InterPro Entry P55064

    ProtoNet protein and cluster: P55064

    1 Blocks protein domain: IPB000425 MIP family

    UniProtKB/Swiss-Prot: AQP5_HUMAN, P55064
    Domain: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming
    loop with the signature motif Asn-Pro-Ala (NPA)
    Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family


    AQP5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AQP5_HUMAN, P55064
    Function: Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions

         Genatlas biochemistry entry for AQP5:
    aquaporin 5,water channel forming integral protein,expressed in salivary and lacrymal glands,cornea
    epithelium,lung,in apical but not in basal turn of the cochlea and putatively involved in low frequency hearing
    (MIP family)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005515protein binding IPI16189514
    GO:0015250water channel activity IDA12801959
         
    AQP5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for AQP5:
     Decreased Wnt reporter activit  Increased TP53 protein express 

         11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Aqp5):
     behavior/neurological  digestive/alimentary  endocrine/exocrine gland  growth/size  hearing/vestibular/ear 
     homeostasis/metabolism  mortality/aging  muscle  no phenotypic analysis  respiratory system 
     vision/eye 

    AQP5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for AQP5: Aqp5tm1Ask Aqp5tm1Amn

       inGenious Targeting Laboratory - Custom generated mouse model solutions for AQP5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for AQP5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for AQP5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AQP5 

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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AQP5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for AQP5 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Regulation of Water Balance by Renal Aquaporins
    Aquaporin-mediated transport0.84
    2SLC-mediated transmembrane transport
    Transmembrane transport of small molecules0.50
    3Nanog in Mammalian ESC Pluripotency
    eNOS Signaling0.48
    4Gastric acid secretion
    Salivary secretion0.34
    5Stabilization and expansion of the E-cadherin adherens junction
    Stabilization and expansion of the E-cadherin adherens junction

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for AQP5
        Selected targets of ESR1

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for AQP5
        eNOS Signaling

    1 BioSystems Pathway for AQP5
        Stabilization and expansion of the E-cadherin adherens junction


    3        Reactome Pathways for AQP5
        Transmembrane transport of small molecules
    Aquaporin-mediated transport
    Passive Transport by Aquaporins


    1         Kegg Pathway  (Kegg details for AQP5):
        Salivary secretion


    AQP5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AQP5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/7 Interacting proteins for AQP5 (P550641, 2, 3 ENSP000002935994) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDFIQ997501, 2, 3, ENSP000002303214EBI-746103,EBI-724076 MINT-66783 I2D: score=5 STRING: ENSP00000230321
    CREB3O438893I2D: score=1 
    STX4ENSP000003177144STRING: ENSP00000317714
    EXOC3ENSP000003233774STRING: ENSP00000323377
    EXOC4ENSP000002538614STRING: ENSP00000253861
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006833water transport TAS--
    GO:0007588excretion TAS8621489
    GO:0015670carbon dioxide transport IDA19273840
    GO:0030157pancreatic juice secretion IEP12801959

    AQP5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    AQP5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for AQP5

    1 IUPHAR Ligand for AQP5 (AQP5)    About this table 
    LigandTypeActionAffinityPubmed IDs
    Hg2+
    InhibitorNone--

    4 Novoseek inferred chemical compound relationships for AQP5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pilocarpine 39.6 2 11773623 (1), 16949105 (1)
    glycerol 13.3 1 17044001 (1)
    calcium 0 3 16537379 (1), 10600522 (1)
    estrogen 0 1 14635794 (1)

    Search CenterWatch for drugs/clinical trials and news about AQP5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for AQP5 gene: 
    NM_001651.3  

    Unigene Cluster for AQP5:

    Aquaporin 5
    Hs.298023  [show with all ESTs]
    Unigene Representative Sequence: NM_001651
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000293599(uc001rvo.2) ENST00000553132
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate AQP5:
    hsa-miR-21* hsa-miR-1226 hsa-miR-185* hsa-miR-634 hsa-miR-3921
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AQP5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AQP5

    Additional mRNA sequence: 

    BC032946.1 CR541989.1 CR542022.1 

    4 DOTS entries:

    DT.212199  DT.100668789  DT.91759665  DT.75101265 

    24/137 AceView cDNA sequences (see all 137):

    BM785545 BI828672 CR541989 BM695989 BG773418 AW589614 BM696473 BF726254 
    AI738904 AI963257 CD674582 CR542022 BM850948 BF439120 BM795210 AI690680 
    BM706122 AA234161 BM705754 AA382090 BM706385 CD676193 BM850852 BU735096 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    AQP5 expression in normal human tissues (normalized intensities)      AQP5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGTGGGGCTG
    AQP5 Expression
    About this image


    AQP5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             Alveolar Epithelial Type 1 Cells Alveoli
             Lung epithelial-like cells ( Derivation of lung epithelial cells from human embryonic...
             Trachea   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             umbilical cord reticulocytes   
     
     Umbilical Cord (Extraembryonic Tissues)
             umbilical cord reticulocytes   
     
     Kidney (Urinary System)
             Type B cells Renal Collecting Duct System
     
     Epithelium (Respiratory System)
             bronchial epithelia   

    See AQP5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for AQP5

    SOURCE GeneReport for Unigene cluster: Hs.298023
        SABiosciences Expression via Pathway-Focused PCR Array including AQP5: 
              Osmotic Stress in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AQP5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for AQP5 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aqp51 , 5 aquaporin 51, 5 86.44(n)1
    91.25(a)1
      15 (56.13 cM)5
    118301  NM_009701.41  NP_033831.11 
     995910285 
    chicken
    (Gallus gallus)
    Aves AQP51 aquaporin 5 77.19(n)
    76.05(a)
      431305  XM_001231780.2  XP_001231781.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    75(a)
    75(a)
    (see all 4)
    1 ↔ many
    1 ↔ many
    (see all 4)
    GL344577.1(1580-8200)
    2(96166576-96172077)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG77773 water transporter 41(a)   47F13   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AQY11 Aqy1p 42.05(n)
    30.23(a)
      856322   NP_015518.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons DELTA-TIP1 aquaporin TIP2-1 50.88(n)
    43.06(a)
      820870  NM_112495.3  NP_188245.1 
    corn
    (Zea mays)
    Liliopsida Zm.144362 Zea mays plasma membrane integral protein ZmPIP2-1 more 74.91(n)    AF326491.1 


    ENSEMBL Gene Tree for AQP5 (if available)
    TreeFam Gene Tree for AQP5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for AQP5 gene
    ENSG000002504242  AQP82  AQP22  MIP2  AQP12  AQP42  AQP62  
    7 SIMAP similar genes for AQP5 using alignment to 1 protein entry:     AQP5_HUMAN:
    AQP6    AQP2    MIP    DKFZp434D2030    AQP4    AQP1
    AQP8

    AQP5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/236 SNPs in AQP5 are shown (see all 236)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs19646761,2
    C,F,A,H--50192804(-) TGGAAT/CGTGAG 1 -- ut3115Minor allele frequency- C:0.45NA WA CSA EA NS 3194
    rs1869151421,2
    --50353506(+) CCCCAA/GTGGCC 1 -- us2k10--------
    rs1415982771,2
    C--50353598(+) CATGAC/TTGGCT 1 -- us2k10--------
    rs1504822971,2
    --50354148(+) GAGAGA/GGTGGT 1 -- us2k10--------
    rs1922280391,2
    --50354267(+) GAGACC/TGAGAA 1 -- us2k10--------
    rs1155085421,2
    F--50354399(+) TGAGAG/CAAATG 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1852258231,2
    --50354403(+) AGAAAC/TGAATA 1 -- us2k10--------
    rs37591291,2
    C,F,H--50354437(+) AGCAAA/CAGGCA 1 -- us2k116Minor allele frequency- C:0.08EA NS NA WA 2788
    rs1383014021,2
    --50354496(+) AGGTGA/GAGAAC 1 -- us2k10--------
    rs1885429131,2
    --50354529(+) GACCTC/TTCGGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for AQP5 (50355279 - 50359464 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for AQP5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832407CNV Loss17160897
    nsv899073CNV Loss21882294
    nsv899074CNV Loss21882294
    nsv899072CNV Loss21882294
    esv27744CNV Loss19812545
    nsv523899CNV Loss19592680
    nsv522972CNV Gain19592680


    Human Gene Mutation Database (HGMD): AQP5
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing AQP5
    DNA2.0 Custom Variant and Variant Library Synthesis for AQP5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600442    OMIM disorders: --

    20/32 diseases for AQP5 (see all 32):    About MalaCards
    dry eye syndrome    excessive tearing    dacryoadenitis    meniere's disease
    menieres disease    congenital diaphragmatic hernia    keratoconjunctivitis sicca    pterygium
    idiopathic pulmonary fibrosis    hernia    keratoconjunctivitis    sjogren's syndrome
    keratoconus    respiratory failure    chronic obstructive pulmonary disease    lung adenocarcinoma
    pulmonary fibrosis    cystic fibrosis    allergic rhinitis    rhinitis

    2 diseases from the University of Copenhagen DISEASES database for AQP5:
    Respiratory failure     Sjogren's syndrome

    AQP5 for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for AQP5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    xerostomia 58.2 3 11232635 (1), 10476940 (1), 15640830 (1)
    sjogrens syndrome 55.1 12 11247557 (3), 15640830 (2), 15940770 (2), 11232635 (1) (see all 6)
    dry eye syndromes 51.9 1 11247557 (1)
    nasal polyps 47.1 27 19166033 (7), 15938209 (5), 15715403 (2)
    asthma 0 5 18647319 (3), 11707570 (1)
    tumors 0 8 16242760 (5), 18478076 (1)
    cystic fibrosis 0 1 12801959 (1)

    Genetic Association Database (GAD): AQP5
    Human Genome Epidemiology (HuGE) Navigator: AQP5 (5 documents)

    Export disorders for AQP5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for AQP5 gene, integrated from 9 sources (see all 139):
    (articles sorted by number of sources associating them with AQP5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human aquaporin-5 gene. Molecular characterization and chromosomal localization. (PubMed id 8621489)1, 2, 3, 9 Lee M.D.... Agre P. (1996)
    2. A novel-1364A/C aquaporin 5 gene promoter polymorphism influences the responses to salt loading of the renin-angiotensin-aldosterone system and of blood pressure in young healthy men. (PubMed id 18846354)1, 4, 9 Adamzik M....Siffert W. (2008)
    3. Polymorphisms of aquaporin5 gene in chronic obstructive pulmonary disease in a Chinese population. (PubMed id 18853286)1, 4, 9 Ning Y....Wen F. (2008)
    4. Mutations in AQP5, Encoding a Water-Channel Protein, C ause Autosomal-Dominant Diffuse Nonepidermolytic Palmoplantar Keratoderma. (PubMed id 23830519)1, 3 Blaydon D.C....Kelsell D.P. (2013)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Expression of aquaporin 5 (AQP5) promotes tumor invasion in human non small cell lung cancer. (PubMed id 18478076)1, 9 Chae Y.K....Moon C. (2008)
    7. Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions. (PubMed id 16537379)1, 9 Sidhaye V.K....King L.S. (2006)
    8. Membrane trafficking of AQP5 and cAMP dependent phosphorylation in bronchial epithelium. (PubMed id 18042467)1, 9 Woo J....Moon C. (2008)
    9. Human AQP5 plays a role in the progression of chronic myelogenous leukemia (CML). (PubMed id 18612408)1, 9 Chae Y.K....Moon C. (2008)
    10. Comparative expression analysis of aquaporin-5 (AQP5) in keratoconic and healthy corneas. (PubMed id 18449356)1, 9 Garfias Y....Zenteno J.C. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 362 HGNC: 638 AceView: AQP5 Ensembl:ENSG00000161798 euGenes: HUgn362
    ECgene: AQP5 Kegg: 362 H-InvDB: AQP5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for AQP5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for AQP5 gene:
    Search GeneIP for patents involving AQP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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