Aliases for AQP3 Gene
Aliases for AQP3 Gene
External Ids for AQP3 Gene
- HGNC: 636
- Entrez Gene: 360
- Ensembl: ENSG00000165272
- OMIM: 600170
- UniProtKB: Q92482
Previous GeneCards Identifiers for AQP3 Gene
- GC09M033753
- GC09M033610
Summaries for AQP3 Gene
-
This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
GeneCards Summary for AQP3 Gene
AQP3 (Aquaporin 3 (Gill Blood Group)) is a Protein Coding gene. Diseases associated with AQP3 include Oligohydramnios and Pompholyx. Among its related pathways are Aquaporin-mediated transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity and glycerol channel activity. An important paralog of this gene is AQP10.
UniProtKB/Swiss-Prot for AQP3 Gene
-
Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).
-
Aquaporins (AQPs) are integral membrane proteins that facilitate the transport of water across biological membranes along an osmotic gradient. There have been 13 AQP isoforms (AQP0-AQP12) identified in humans and rodents to date.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AQP3 Gene
Genomics for AQP3 Gene
Regulatory Elements for AQP3 Gene
Enhancers for AQP3 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH09G033413 | 1.6 | Ensembl ENCODE dbSUPER | 22.2 | +31.2 | 31208 | 4.9 | PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 | AQP3 NOL6 NFX1 AQP7 LOC105376020 PIR43065 |
| GH09G033390 | 1.5 | Ensembl ENCODE dbSUPER | 18.5 | +54.7 | 54682 | 5.8 | PKNOX1 MLX SIN3A ARID4B DMAP1 FEZF1 YY1 GTF3C2 ZNF121 FOS | ASS1P12 AQP3 ENSG00000228352 TCEA1P4 DFFBP1 AQP7 TOPORS SMU1 NFX1 DDX58 |
| GH09G033436 | 0.9 | ENCODE dbSUPER | 28.7 | +10.6 | 10636 | 0.6 | KLF1 ZFP64 CEBPB CEBPG NR2F2 ZNF592 ARID1B CEBPA IKZF1 KDM1A | AQP3 AQP7 NOL6 PIR43065 |
| GH09G033442 | 1.7 | FANTOM5 ENCODE dbSUPER | 13.9 | +2.2 | 2242 | 6.2 | HDGF PKNOX1 MLX ARID4B SIN3A YY1 ZNF766 FOS DEK ZNF263 | AQP7 AQP3 NOL6 PTENP1 NFX1 BAG1 SMU1 PIR43065 |
| GH09G033424 | 0.7 | dbSUPER | 29.8 | +22.3 | 22322 | 0.7 | FOXA2 SAP130 RARA CREM MIXL1 GATAD2A FOXA3 HMG20A PPARG HHEX | AQP3 PIR43065 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around AQP3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the AQP3 gene promoter:
Regulatory Element Products
Genomic Location for AQP3 Gene
- Chromosome:
- 9
- Start:
- 33,441,154 bp from pter
- End:
- 33,447,633 bp from pter
- Size:
- 6,480 bases
- Orientation:
- Minus strand
Genomic View for AQP3 Gene
Genes around AQP3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9p13.3 by Ensembl
- 9p13.3 by Entrez Gene
- 9p13.3 by HGNC
AQP3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AQP3 Gene
Proteins for AQP3 Gene
-
Protein details for AQP3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q92482-AQP3_HUMAN
- Recommended name:
- Aquaporin-3
- Protein Accession:
- Q92482
- A8K843
- B2RE16
- D3DRL3
- O00108
- Q6FGT2
- Q6FGW6
Protein attributes for AQP3 Gene
- Size:
- 292 amino acids
- Molecular mass:
- 31544 Da
- Quaternary structure:
- No Data Available
Protein Expression for AQP3 Gene
Post-translational modifications for AQP3 Gene
Other Protein References for AQP3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for AQP3
-
Custom Antibody ServicesOriGene Antibodies for AQP3
- Novus Biologicals Antibodies for AQP3
-
Abcam antibodies for AQP3
- Invitrogen Antibodies for AQP3
- antibodies-online Antibodies for AQP3: See all 104
- GeneTex AQP3 antibody for AQP3
Protein Products
-
OriGene Purified Proteins for AQP3
- Search Origene for MassSpec and Protein Over-expression Lysates for AQP3
- Origene Custom Protein Services for AQP3
- Search GeneTex for Proteins for AQP3
-
Abcam proteins for AQP3
Assay Products
- antibodies-online Kits for AQP3: See all 43
No data available for DME Specific Peptides for AQP3 Gene
Domains & Families for AQP3 Gene
Gene Families for AQP3 Gene
- HGNC:
- IUPHAR :
Protein Domains for AQP3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for AQP3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q92482UniProtKB/Swiss-Prot:
AQP3_HUMAN :- Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
- Belongs to the MIP/aquaporin (TC 1.A.8) family.
- Domain:
-
- Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
- Family:
-
- Belongs to the MIP/aquaporin (TC 1.A.8) family.
Function for AQP3 Gene
Molecular function for AQP3 Gene
- GENATLAS Biochemistry:
- aquaporin 3,water channel,forming integral protein (basolateral membrane of collecting duct cell),providing the exit pathway to interstitium,also expressed in colon,localized in villus epithelial cells,involved in water absorption across human colonic surface cells
- UniProtKB/Swiss-Prot Function:
- Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by magnesium.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005215 | transporter activity | NAS | 7543093 |
| GO:0015250 | water channel activity | TAS | 17943189 |
| GO:0015254 | glycerol channel activity | IDA | 17943189 |
Phenotypes for AQP3 Gene
- MGI mutant phenotypes for AQP3:
-
inferred from 3 alleles
- mortality/aging
- behavior/neurological phenotype
- growth/size/body region phenotype
- immune system phenotype
- homeostasis/metabolism phenotype
- cardiovascular system phenotype
- respiratory system phenotype
- digestive/alimentary phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- renal/urinary system phenotype
- craniofacial phenotype
- taste/olfaction phenotype
- GenomeRNAi human phenotypes for AQP3:
Animal Model Products
-
Taconic Biosciences Mouse Models for AQP3
- Cyagen custom Knockout/knockin (KOKI) mouse models for AQP3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for AQP3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AQP3 gene
- Search ViGene Biosciences for AQP3
CRISPR Products
-
OriGene CRISPR knockouts for AQP3
-
Santa Cruz Biotechnology (SCBT) CRISPR for AQP3
- GenScript: Design CRISPR guide RNA sequences for AQP3
miRNA for AQP3 Gene
- miRTarBase miRNAs that target AQP3
-
- hsa-mir-615-3p (MIRT040256)
- hsa-mir-874-3p (MIRT053376)
- hsa-mir-185-5p (MIRT438336)
- hsa-mir-6882-3p (MIRT611606)
- hsa-mir-4641 (MIRT611607)
- hsa-mir-6893-3p (MIRT611608)
- hsa-mir-370-3p (MIRT611609)
- hsa-mir-4789-3p (MIRT611610)
- hsa-mir-8485 (MIRT611611)
- hsa-mir-4643 (MIRT626527)
- hsa-mir-6809-3p (MIRT664403)
- hsa-mir-4753-3p (MIRT664404)
- hsa-mir-1236-3p (MIRT664405)
- hsa-mir-6515-3p (MIRT664406)
- hsa-mir-653-5p (MIRT695322)
- hsa-mir-6869-5p (MIRT695323)
- hsa-mir-877-5p (MIRT695324)
- hsa-mir-889-3p (MIRT695325)
- hsa-mir-3163 (MIRT695326)
- hsa-mir-3159 (MIRT695327)
- hsa-mir-6859-5p (MIRT695328)
- hsa-mir-3916 (MIRT695329)
- hsa-mir-3125 (MIRT695330)
- hsa-mir-1277-5p (MIRT695331)
- hsa-mir-559 (MIRT695332)
- hsa-mir-548y (MIRT695333)
- hsa-mir-548w (MIRT695334)
- hsa-mir-548o-5p (MIRT695335)
- hsa-mir-548j-5p (MIRT695336)
- hsa-mir-548i (MIRT695337)
- hsa-mir-548h-5p (MIRT695338)
- hsa-mir-548d-5p (MIRT695339)
- hsa-mir-548c-5p (MIRT695340)
- hsa-mir-548bb-5p (MIRT695341)
- hsa-mir-548b-5p (MIRT695342)
- hsa-mir-548ay-5p (MIRT695343)
- hsa-mir-548au-5p (MIRT695344)
- hsa-mir-548as-5p (MIRT695345)
- hsa-mir-548ar-5p (MIRT695346)
- hsa-mir-548aq-5p (MIRT695347)
- hsa-mir-548ap-5p (MIRT695348)
- hsa-mir-548am-5p (MIRT695349)
- hsa-mir-548ak (MIRT695350)
- hsa-mir-548ae-5p (MIRT695351)
- hsa-mir-548ad-5p (MIRT695352)
- hsa-mir-548ab (MIRT695353)
- hsa-mir-548a-5p (MIRT695354)
- hsa-mir-548t-5p (MIRT695355)
- hsa-mir-548az-5p (MIRT695356)
- hsa-mir-548n (MIRT695357)
miRNA Products
- Search ViGene Biosciences for AQP3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for AQP3
- Browse OriGene Inhibitory RNA Products For AQP3
-
ViGene Biosciences ready-to-package AAV shRNAs for AQP3 gene
Clone Products
- Sino Biological Human cDNA Clone for AQP3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for AQP3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AQP3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for AQP3
-
ViGene Biosciences adenoviral particle packaged cDNA for AQP3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for AQP3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for AQP3 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AQP3 Gene
Localization for AQP3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for AQP3 Gene
- Basolateral cell membrane; Multi-pass membrane protein. Note=In collecting ducts of kidney.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| extracellular | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
| GO:0005737 | cytoplasm | IDA | 18718702 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005911 | cell-cell junction | IDA | 18718702 |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for AQP3 Gene
Pathways by source for AQP3 Gene
2 BioSystems pathways for AQP3 Gene
1 KEGG pathway for AQP3 Gene
1 Qiagen pathway for AQP3 Gene
Interacting Proteins for AQP3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002684 | positive regulation of immune system process | IDA | 17943189 |
| GO:0003091 | renal water homeostasis | TAS | -- |
| GO:0006810 | transport | NAS | 7543093 |
| GO:0006833 | water transport | TAS | 17943189 |
| GO:0007588 | excretion | TAS | 7543093 |
No data available for SIGNOR curated interactions for AQP3 Gene
Transcripts for AQP3 Gene
mRNA/cDNA for AQP3 Gene
- (2) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (318) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for AQP3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for AQP3
-
Santa Cruz Biotechnology (SCBT) CRISPR for AQP3
- GenScript: Design CRISPR guide RNA sequences for AQP3
miRNA Products
- Search ViGene Biosciences for AQP3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for AQP3
- Browse OriGene Inhibitory RNA Products For AQP3
-
ViGene Biosciences ready-to-package AAV shRNAs for AQP3 gene
Clone Products
- Sino Biological Human cDNA Clone for AQP3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for AQP3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AQP3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||
| SP7: | - |
Expression for AQP3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Epithelial Cells
-
Blood (Hematopoietic System)
- T Helper Cells Peripheral Blood
- Double Positive Thymocytes Thymus
- Hematopoietic Bone Marrow
-
Kidney (Urinary System)
- Collecting Duct Cells Renal Collecting Duct System
- Adult human kidney epithelial cells
- Renal proximal tubularlike cells(Narayanan K et. al. 2013)
-
Hair (Integumentary System)
- Bulge Stem Cells Bulge
-
Thymus (Hematopoietic System)
- Double Positive Thymocytes Thymus
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Ovary (Reproductive System)
- Inner Cell Mass (Early Embryonic Tissues)
- Liver (Hepatobiliary System)
-
Prostate (Endocrine System)
-
Lung (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for AQP3 Gene
This gene is overexpressed in Esophagus - Mucosa (x16.0), Skin - Not Sun Exposed (Suprapubic) (x6.6), Minor Salivary Gland (x5.7), Skin - Sun Exposed (Lower leg) (x5.0), and Vagina (x4.9).
This gene is overexpressed in Prostate (21.7), Spleen (21.4), Urinary Bladder (12.1), and Peripheral blood mononuclear cells (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for AQP3 Gene
NURSA nuclear receptor signaling pathways regulating expression of AQP3 Gene:
AQP3SOURCE GeneReport for Unigene cluster for AQP3 Gene:
Hs.234642mRNA Expression by UniProt/SwissProt for AQP3 Gene:
Q92482-AQP3_HUMAN
Tissue specificity:
Widely expressed in epithelial cells of kidney (collecting ducts) and airways, in keratinocytes, immature dendritic cells and erythrocytes. Isoform 2 is not detectable in erythrocytes at the protein level.
Evidence on tissue expression from TISSUES for AQP3 Gene
- Lung(4.8)
- Kidney(4.7)
- Blood(4.3)
- Skin(3.4)
- Nervous system(2.9)
- Liver(2.6)
- Intestine(2.4)
- Spleen(2.3)
- Stomach(2.3)
- Pancreas(2.1)
Primer Products
-
OriGene qPCR primer pairs for AQP3
-
OriGene qPCR primer pairs and template standards for AQP3
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AQP3 Gene
Orthologs for AQP3 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | AQP3 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | AQP3 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | AQP3 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | AQP3 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Aqp3 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Aqp3 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | AQP3 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | AQP3 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | AQP3 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | aqp3 34 |
|
||
| Str.15346 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | aqp3 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | aqp3b 34 35 |
|
||
| aqp3a 35 |
|
OneToMany | |||
| Dr.922 34 |
|
||||
| worm (Caenorhabditis elegans) |
Secernentea | C01G6.1a 36 |
|
|
|
| C01G6.1b 36 |
|
|
|||
| aqp-2 35 |
|
ManyToMany | |||
| Y69E1A.7 36 |
|
|
|||
| M02F4.8 36 |
|
|
|||
| aqp-7 35 |
|
ManyToMany | |||
| aqp-8 35 |
|
ManyToMany | |||
| aqp-1 35 |
|
ManyToMany | |||
| aqp-3 35 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | YFL054C 34 |
|
||
| -- 35 |
|
OneToMany | |||
| AQY3 37 |
|
|
|||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC977.17 34 |
|
- Species where no ortholog for AQP3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for AQP3 Gene
(5) SIMAP similar genes for AQP3 Gene using alignment to 2 proteins:
Variants for AQP3 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for AQP3 Gene
- AQP3_HUMAN-Q92482
- AQP3 is responsible for the GIL blood group system. Isoform 2 is detected in GIL-negative individuals that lack functional AQP3.
| SNP ID | Clin | Chr 09 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000243316 | -- | 33,448,973(+) | GCCTC(A/G)AACTC | upstream-variant-2KB | |
| rs1000670866 | -- | 33,447,747(+) | CGCCG(G/T)GTGGA | upstream-variant-2KB | |
| rs1001129816 | -- | 33,449,322(+) | CCTGA(C/G)GACTT | upstream-variant-2KB | |
| rs1001310244 | -- | 33,441,456(+) | CTCCC(A/C)GCCCT | nc-transcript-variant, utr-variant-3-prime | |
| rs1001873949 | -- | 33,447,804(+) | CTTCG(C/G)AGGGC | upstream-variant-2KB |
Residual Variation Intolerance Score:
15.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.39;
8.68% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for AQP3 Gene
- Human Gene Mutation Database (HGMD)
- AQP3
- Blood Group Antigen Gene Mutation Database (BGMUT)
- Blood Group System
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- AQP3
Disorders for AQP3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| oligohydramnios |
|
|
| pompholyx |
|
|
| polyhydramnios |
|
|
| meniere's disease |
|
|
| hydrarthrosis |
|
|
Search AQP3 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for AQP3
No data available for UniProtKB/Swiss-Prot and Genatlas for AQP3 Gene
Publications for AQP3 Gene
- Structure and chromosomal localization of a human water channel (AQP3) gene. (PMID: 7558005) Ishibashi K. … Marumo F. (Genomics 1995) 2 3 4 22 64
- AQP3 deficiency in humans and the molecular basis of a novel blood group system, GIL. (PMID: 12239222) Roudier N. … Bailly P. (J. Biol. Chem. 2002) 3 4 22 64
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
- Expression profile of multiple aquaporins in human gastric carcinoma and its clinical significance. (PMID: 20106632) Shen L. … Wu W. (Biomed. Pharmacother. 2010) 3 22 64
- Relationship between gene expressions of aquaporin 3 and 4 and various degrees of spleen-stomach dampness-heat syndrome in chronic superficial gastritis. (PMID: 20141731) Mei W.X. … Hu B. (Zhong Xi Yi Jie He Xue Bao 2010) 3 22 64
Products for AQP3 Gene
- Browse R&D Systems for Antibodies
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- Browse R&D Systems for biochemical assays
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- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for AQP3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for AQP3
- Search Origene for MassSpec and Protein Over-expression Lysates for AQP3
- Origene Custom Protein Services for AQP3
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for AQP3
- Browse OriGene Inhibitory RNA Products For AQP3
- OriGene qPCR primer pairs and template standards for AQP3
- OriGene qPCR primer pairs for AQP3
- OriGene CRISPR knockouts for AQP3
- OriGene ORF clones in human for AQP3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For AQP3
- GenScript: Next-day shipping cDNA ORF clone for AQP3 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for AQP3
- GenScript Custom Assay Services for AQP3
- GenScript Custom overexpressing Cell Line Services for AQP3
- GenScript: Design CRISPR guide RNA sequences for AQP3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for AQP3
- Sino Biological Human cDNA Clone for AQP3
- Browse Sino Biological Cell Lysates
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- Sino Biological Antibodies
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- Sino Biological Cell Lysates
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- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for AQP3
- Novus Biologicals proteins and lysates for AQP3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for AQP3
- Abcam proteins for AQP3
- Search for Assays for AQP3 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Taconic Biosciences Mouse Models for AQP3
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- antibodies-online Antibodies for AQP3: See all 104
- antibodies-online Kits for AQP3: See all 43
- Search antibodies-online for proteins
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- GeneTex AQP3 antibody for AQP3
- Search GeneTex for Proteins for AQP3
- ViGene Biosciences adenoviral particle packaged cDNA for AQP3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for AQP3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for AQP3 gene
- Search ViGene Biosciences for AQP3
- Horizon Cell Lines for AQP3
- Cyagen custom Knockout/knockin (KOKI) mouse models for AQP3
- VectorBuilder custom plasmid, inducible vectors for AQP3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AQP3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for AQP3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
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- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
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- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
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- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
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- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
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- (90) Invitrogen
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- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
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- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
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- (148) SNPedia
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- (154) TISSUES
- (155) Gene ORGANizer