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AQP3 Gene

protein-coding GIFtS: 60

GC09M033431

aquaporin 3 (Gill blood group)
(Previous names: aquaporin 3, aquaporin 3 (GIL blood group) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AQP-3 ^³
GIL ^¹, ²
OTTHUMP00000021206 ^²

Descriptions
Gill blood group ^²
aquaporin 3 ^¹, ²
aquaporin 3 (GIL blood group) ^¹, ²
aquaporin 3 (Gill blood group) ^²

External Ids
HGNC: 636¹
Entrez Gene: 360²
UniProtKB: Q92482³
Ensembl: ENSG00000165272⁷

Search outside databases for aliases for AQP3 gene

Previous GC identifers: GC09M033753 GC09M033610

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for AQP3:

Aquaporin 3 is a water channel protein. Aquaporins are a family of small integral membrane proteins

related to the major intrinsic protein (MIP or AQP0). Aquaporin 3 is localized at the basal

lateral membranes of collecting duct cells in the kidney. In addition to its water channel

function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as

urea and glycerol, but to a smaller degree. It has been suggested that water channels can be

functionally heterogeneous and possess water and solute permeation mechanisms. [provided by

RefSeq]

UniProtKB/Swiss-Prot: AQP3_HUMAN, Q92482

Function: Forms a water-specific channel that provide kidney medullary collecting duct with high

permeability to water, thereby permitting water to move in the direction of an osmotic gradient.

May function as a water and urea exit mechanism in antidiuresis in collecting duct cells. Also

slightly permeable to urea and glycerol. May play an important role in gastrointestinal tract

water transport and in glycerol metabolism (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the AQP3 gene

Entrez Gene cytogenetic band: 9p13 Ensembl cytogenetic band: 9p13.3 HGNC cytogenetic band: 9p13

AQP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M033431: (about GC identifiers)

Start:	33,431,158 bp from pter
End:	33,437,590 bp from pter
Size:	6,433 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000009.10 NT_008413.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: AQP3_HUMAN, Q92482 (See protein sequence)

Recommended Name: Aquaporin-3

Size: 292 amino acids; 31544 Da

Subcellular location: Basolateral cell membrane; Multi-pass membrane protein. Note=In collecting

ducts of kidney

Secondary accessions: O00108 Q6FGW6

Alternative splicing: 2 isoforms: Q92482-1 Q92482-2

REFSEQ proteins: NP_004916.1

ENSEMBL proteins:

ENSP00000339229 ENSP00000297991 ENSP00000368806

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Aquaporin 3)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--
GO:0016323	basolateral plasma membrane	IEA	--

About this table

Antibodies for AQP3:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of AQP3
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Aquaporin 3), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for AQP3

Assays for AQP3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q92482

ProtoNet protein and cluster: Q92482

1 Blocks protein family: IPB000425 MIP family

UniProtKB/Swiss-Prot: AQP3_HUMAN, Q92482

Domain: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a

pore-forming loop with the signature motif Asn-Pro-Ala (NPA)

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AQP3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AQP3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004925

Applied Biosystems Silencer® siRNAs for AQP3

Sigma-Aldrich siRNA and siRNA Panels for AQP3

Sigma-Aldrich shRNA for AQP3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004925
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004925
untagged cDNA clones in CMV expression vector (see all 2): NM_004925

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004925

UniProtKB/Swiss-Prot: AQP3_HUMAN, Q92482

Function: Forms a water-specific channel that provide kidney medullary collecting duct with high

permeability to water, thereby permitting water to move in the direction of an osmotic gradient.

May function as a water and urea exit mechanism in antidiuresis in collecting duct cells. Also

slightly permeable to urea and glycerol. May play an important role in gastrointestinal tract

water transport and in glycerol metabolism (By similarity)

Genatlas biochemistry entry for AQP3:

aquaporin 3,water channel,forming integral protein (basolateral membrane of collecting duct

cell),providing the exit pathway to interstitium,also expressed in colon,localized in villus

epithelial cells,involved in water absorption across human colonic surface cells

7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Aqp3):

behavior/neurological	hearing/vestibular/ear	homeostasis/metabolism	renal/urinary system	respiratory system
taste/olfaction	vision/eye

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005215	transporter activity	NAS	7543093
GO:0015250	water channel activity	TAS	17943189
GO:0015254	glycerol channel activity	IDA	17943189

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for AQP3

5/18 Interacting proteins for AQP3 (ENSP00000297991³) via UniProtKB, MINT, and/or STRING (see all 18 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EXOC3	ENSP00000323377³	STRING (score=.899)
EXOC4	ENSP00000253861³	STRING (score=.899)
STX4	ENSP00000317714³	STRING (score=.899)
INS	ENSP00000370731³	STRING (score=.882)
NPPA	ENSP00000365663³	STRING (score=.873)

About this table

5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002684	positive regulation of immune system process	IDA	17943189
GO:0006810	transport	NAS	7543093
GO:0006833	water transport	TAS	17943189
GO:0007588	excretion	TAS	7543093
GO:0032526	response to retinoic acid	IDA	17943189

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for AQP3
10/12 Novoseek chemical compound relationships for AQP3 gene (see all 12 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
urea	55.52	13	8810261 (3), 7517548 (2), 11597198 (1), 10510269 (1) (see all 7)
hgcl2	52.95	1	9369468 (1)
mercury chloride	50.61	1	9124401 (1)
2-mercaptoethanol	20.71	1	9124401 (1)
oligonucleotide	13.42	4	12769265 (1), 10510269 (1)
forskolin	11.15	2	16638588 (1)
chloride	2.56	1	12531781 (1)
sucrose	0.00	1	11751877 (1)
glucose	0.00	6	12234316 (4), 15931648 (1), 16651733 (1)
mercury	0.00	3	9369468 (3)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (AQP3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (AQP3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004925

Sigma-Aldrich siRNA and siRNA Panels for AQP3

Sigma-Aldrich shRNA for AQP3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004925

REFSEQ mRNAs for AQP3 gene:

NM_004925.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004925

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004925
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004925
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004925

Additional cDNA sequence:

AJ493597.1 AK292208.1 AK303206.1 AK315760.1 BC012988.2 BC013566.1 BT007199.1 CR541991.1

CR542025.1 CR592288.1 CR598676.1 CR599072.1 CR599108.1 CR604170.1 CR607893.1 CR614710.1

CR624600.1

20 DOTS entries:

DT.450022 DT.100788373 DT.100788368 DT.100727049 DT.100788375 DT.121162831 DT.121162819 DT.121162856

DT.121162838 DT.97864190 DT.100645939 DT.100762945 DT.121162844 DT.95261961 DT.95261964 DT.95261965

DT.95261971 DT.100682373 DT.121162826 DT.95149103

24/318 AceView cDNA sequences (see all 318 ):

AW084220 CR604170 AA715246 CR598676 BM549986 AW273155 CA454222 BP334437

BM907330 CR592288 BF437236 BC012988 CB242362 CB242374 AI635233 BQ224811

CR607893 NM_004925 BI333194 BU168336 CB529975 CR624600 CR614710 BP340426

highest scoring ESTs for AQP3:

AA630981 AB001325 AJ493597 AL523755 AL531396 AL548429 AL556191 AL557210 AU098731 AU279997

Unigene Cluster for AQP3:

Aquaporin 3 (Gill blood group)

Hs.234642 [show with all ESTs]

Unigene Representative Sequence: NM_004925

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for AQP3 (see all 7 )

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6	^	7a	·	7b	·	7c
SP1:							-				-		-
SP2:							-				-		-						-
SP3:											-		-
SP4:							-						-
SP5:

About this scheme

ECgene alternative splicing isoforms for AQP3

3 Ensembl transcripts including schematic representations:

ENST00000343952 ENST00000297991 ENST00000379492

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

AQP3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for AQP3

¹ / ² / ³

9 probe-sets matching AQP3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
47982_at²^{, 3}	U95-B	1	1.00	1.00	0.99	1.22	AA630981	0.80	1.00	0.91	1
39249_at²^{, 3}	U133-A	1	1.00	1.00	0.96	0.74	AB001325	0.80	1.00	0.91	1
39248_at²^{, 3}	U133-A	1	1.00	1.00	0.99	1.05	N74607	0.80	1.00	0.91	1
39249_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AB001325	0.80	1.00	0.91	1
39248_at²^{, 3}	U133-A	1	1.00	1.00	--	--	N74607	0.80	1.00	0.91	1
203747_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004925	0.60	1.00	0.82	1
39249_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
39248_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203747_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks AQP3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTTGCTTTTG

SOURCE GeneReport for Unigene cluster: Hs.234642
Expression variation in blood from EXPOLDB for AQP3
UniProtKB/Swiss-Prot: AQP3_HUMAN, Q92482
Tissue specificity: Widely expressed in epithelial cells of kidney (collecting ducts) and airways,
in keratinocytes, immature dendritic cells and erythrocytes. Isoform 2 is not detectable in
erythrocytes at the protein level

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for AQP3 gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	AQP3¹	--	aquaporin 3 (Gill blood group)	90.75(n) 95.21(a)	611792 XM_849503.1 XP_854596.1
chimpanzee (Pan troglodytes)	AQP3¹	--	aquaporin 3 (Gill blood group)	99.54(n) 99.32(a)	465045 XM_520531.2 XP_520531.1
cow (Bos taurus)	AQP3¹	--	aquaporin 3 (Gill blood group)	90.64(n) 94.86(a)	780866 XM_001251663.1 XP_001251664.1
rat (Rattus norvegicus)	Aqp3¹	--	aquaporin 3	88.01(n) 94.52(a)	65133 NM_031703.1 NP_113891.1
mouse (Mus musculus)	Aqp3^{1, 5}	4⁵	aquaporin 3^{1, 5}	88.36(n)¹ 95.55(a)¹	11828¹ NM_016689.2¹ NP_057898.2¹ AB019039⁵ AF104416⁵ (see all 10)

About this table Species with no ortholog for AQP3

ENSEMBL Gene Tree for AQP3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for AQP3 gene

AQP7P3² AQP9² AQP10² AQP7P1² AQP7² AQP7P4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: AQP3_HUMAN, Q92482

Polymorphism: AQP3 is responsible for the GIL blood group system. Isoform 2 is detected in

GIL-negative individuals that lack functional AQP3

10/134 NCBI SNPs in AQP3 are shown (see all 134 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 84)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs16919255^1,2	C,F,H	33431826(+)	`AATTCC/AGGTTC`	1	--	ut3¹ ese³		13	NA EU EA WA NS	1054
--	rs3860987^1,2	A,C,F	33438959(-)	`acagtG/Aagctg`	1	--	ng3¹		2	NS	94
	rs10971513^1,2	C,F,H	33431527(+)	`ATACAC/AATACA`	1	--	ut3¹ ese³		4	EU EA WA	410
--	rs3758279^1,2	C,F	33439411(+)	`AGGCCG/AAGGCG`	1	--	ng3¹		2	NS	90
	rs2231225^1,2	C,F	33437824(-)	`CTTGAC/AGTCCC`	1	--	ng3¹		4	MN EA NS	450
	rs12555686^1,2	C,F	33437547(+)	`GCGGCG/TCTGTC`	1	--	ut5¹ ese³		2	NS	94
	rs17553719^1,2	C,F	33437579(-)	`GCGCCA/GCCGCC`	1	--	ut5¹ ese³		2	NS	94
	rs35141650^1,2	F	33437915(-)	`CTATGA/TCAGCT`	1	--	ng3¹		2	NS	94
	rs34496252^1,2	F	33430966(-)	`CCCAAA/GCTTTC`	1	--	ng5¹		2	NS	94
	rs12378288^1,2	H	33431431(+)	`CAAACC/GTAAGC`	1	--	ut3¹ spl³ ese³		4	EU EA WA	420

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HapMap Linkage Disequilibrium images for AQP3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600170 disorders: 607457

8 Novoseek disease relationships for AQP3 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
adenocarcinoma lung	40.09	1	17056099 (1)
eczema	15.25	3	16918518 (2), 16872579 (1)
cystic fibrosis	1.65	2	10206998 (1), 10869574 (1)
lung diseases	0.01	1	9374739 (1)
carcinoma	0.00	1	17056099 (1)
tumors	0.00	7	17056099 (2), 11912242 (1), 18214481 (1), 17967887 (1) (see all 5)
adenocarcinoma	0.00	7	17056099 (4), 18604784 (1), 19340551 (1)
edema	0.00	1	16872579 (1)

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Blood Group Antigen Gene Mutation Database (BGMUT) GILL blood group system

Human Gene Mutation Database: AQP3

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/136 PubMed articles for AQP3 gene (see all 136 ):

Structure and chromosomal localization of a human water channel (AQP3) gene. (PubMed id 7558005)^{1, 2, 3, 4} Ishibashi K.... Marumo F. (1995)
AQP3 deficiency in humans and the molecular basis of a novel blood group system, GIL. (PubMed id 12239222)^{1, 3, 4} Roudier N.... Bailly P. (2002)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{3, 4} Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Expression of aquaporin 3 (AQP3) in normal and neoplastic lung tissues. (PubMed id 17056099)^{1, 3} Liu Y.L....Katoh R. (2007)
Aquaporin 3 expression in human fetal membranes and its up-regulation by cyclic adenosine monophosphate in amnion epithelial cell culture. (PubMed id 16638588)^{1, 3} Wang S....Ross M.G. (2006)
Membrane trafficking of aquaporin 3 induced by epinephrine. (PubMed id 18601899)^{1, 3} Yasui H....Hirano K. (2008)
Expression of aquaporin-3 in human peritoneal mesothelial cells and its up-regulation by glucose in vitro. (PubMed id 12234316)^{1, 3} Lai K.N....Chan T.M. (2002)
Expression of aquaporin 3 and its localization in normal skeletal myofibres. (PubMed id 12769265)^{1, 3} Wakayama Y....Oniki H. (2002)
The expression of differentiation markers in aquaporin-3 deficient epidermis. (PubMed id 19184071)^{1, 3} Hara-Chikuma M....Miyachi Y. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 360	HGNC: 636	AceView: AQP3	Ensembl:ENSG00000165272	euGenes: HUgn360
ECgene: AQP3	H-InvDB: AQP3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
dbRBC/BGMUT	http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=gil
SeattleSNPs	http://pga.gs.washington.edu/data/aqp3/

Licensable Technologies for AQP3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for AQP3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for AQP3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for AQP3		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for AQP3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Search for Antibodies
	Chimera RNAi (AQP3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Aquaporin 3)
	Antibodies (Aquaporin 3)

Search OriGene for AQP3

Search Tocris compounds for AQP3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for AQP3

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
AQP3 Gene at Home site.
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AQP3 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for AQP3

Summaries
for AQP3

Genomic Location
for AQP3

Proteins
for AQP3

Protein Domains/
Families
for AQP3

Gene Function
for AQP3

Pathways & Interactions
for AQP3

Drugs & Compounds
for AQP3

Transcripts
for AQP3

Expression
for AQP3

Orthologs
for AQP3

Paralogs
for AQP3

SNPs/Variants
for AQP3

Disorders & Mutations
for AQP3

Medical News
for AQP3

Publications
for AQP3

Search for AQP3

Genome Databases showing AQP3

Other Databases showing AQP3

Specialized Databases showing AQP3

Licensable Technologies
for AQP3

Services
for AQP3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

AQP3 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor AQP3

Summariesfor AQP3

Genomic Locationfor AQP3

Proteinsfor AQP3

Protein Domains/Familiesfor AQP3

Gene Functionfor AQP3

Pathways & Interactionsfor AQP3

Drugs & Compoundsfor AQP3

Transcriptsfor AQP3

Expression for AQP3

Orthologsfor AQP3

Paralogsfor AQP3

SNPs/Variantsfor AQP3

Disorders & Mutationsfor AQP3

Medical Newsfor AQP3

Publicationsfor AQP3

Search for AQP3

Genome Databases showing AQP3

Other Databases showing AQP3

Specialized Databases showing AQP3

Licensable Technologiesfor AQP3

Servicesfor AQP3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for AQP3

Summaries
for AQP3

Genomic Location
for AQP3

Proteins
for AQP3

Protein Domains/
Families
for AQP3

Gene Function
for AQP3

Pathways & Interactions
for AQP3

Drugs & Compounds
for AQP3

Transcripts
for AQP3

Expression
for AQP3

Orthologs
for AQP3

Paralogs
for AQP3

SNPs/Variants
for AQP3

Disorders & Mutations
for AQP3

Medical News
for AQP3

Publications
for AQP3

Licensable Technologies
for AQP3

Services
for AQP3