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Aliases for AQP11 Gene

Aliases for AQP11 Gene

  • Aquaporin 11 2 3 5
  • AQP-11 3 4
  • AQPX1 3 4

External Ids for AQP11 Gene

Previous GeneCards Identifiers for AQP11 Gene

  • GC11M078840
  • GC11P077523
  • GC11P077027
  • GC11P077028
  • GC11P076978
  • GC11P077300
  • GC11P073599

Summaries for AQP11 Gene

GeneCards Summary for AQP11 Gene

AQP11 (Aquaporin 11) is a Protein Coding gene. Among its related pathways are Aquaporin-mediated transport and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include transporter activity and water channel activity. An important paralog of this gene is AQP12A.

UniProtKB/Swiss-Prot for AQP11 Gene

  • Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.

Tocris Summary for AQP11 Gene

  • Aquaporins (AQPs) are integral membrane proteins that facilitate the transport of water across biological membranes along an osmotic gradient. There have been 13 AQP isoforms (AQP0-AQP12) identified in humans and rodents to date.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AQP11 Gene

Genomics for AQP11 Gene

Regulatory Elements for AQP11 Gene

Enhancers for AQP11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around AQP11 on UCSC Golden Path with GeneCards custom track

Promoters for AQP11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around AQP11 on UCSC Golden Path with GeneCards custom track

Genomic Location for AQP11 Gene

Chromosome:
11
Start:
77,589,391 bp from pter
End:
77,610,356 bp from pter
Size:
20,966 bases
Orientation:
Plus strand

Genomic View for AQP11 Gene

Genes around AQP11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AQP11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AQP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AQP11 Gene

Proteins for AQP11 Gene

  • Protein details for AQP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBQ7-AQP11_HUMAN
    Recommended name:
    Aquaporin-11
    Protein Accession:
    Q8NBQ7

    Protein attributes for AQP11 Gene

    Size:
    271 amino acids
    Molecular mass:
    30203 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AQP11 Gene

Proteomics data for AQP11 Gene at MOPED

Post-translational modifications for AQP11 Gene

Other Protein References for AQP11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for AQP11

No data available for DME Specific Peptides for AQP11 Gene

Domains & Families for AQP11 Gene

Gene Families for AQP11 Gene

Protein Domains for AQP11 Gene

Suggested Antigen Peptide Sequences for AQP11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NBQ7

UniProtKB/Swiss-Prot:

AQP11_HUMAN :
  • Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
  • Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
Domain:
  • Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Family:
  • Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
genes like me logo Genes that share domains with AQP11: view

Function for AQP11 Gene

Molecular function for AQP11 Gene

UniProtKB/Swiss-Prot Function:
Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
genes like me logo Genes that share phenotypes with AQP11: view

Animal Models for AQP11 Gene

MGI Knock Outs for AQP11:

Animal Model Products

  • Taconic Biosciences Mouse Models for AQP11

miRNA for AQP11 Gene

miRTarBase miRNAs that target AQP11

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AQP11 Gene

Localization for AQP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AQP11 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AQP11 Gene COMPARTMENTS Subcellular localization image for AQP11 gene
Compartment Confidence
plasma membrane 5
cytosol 2
endoplasmic reticulum 1
endosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for AQP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with AQP11: view

Pathways & Interactions for AQP11 Gene

genes like me logo Genes that share pathways with AQP11: view

Pathways by source for AQP11 Gene

Interacting Proteins for AQP11 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000318770%0d%0a9606.ENSP00000341208%0d%0a
Selected Interacting proteins: ENSP00000318770 for AQP11 Gene via STRING

Symbol External ID(s) Details
STAT5A

Gene Ontology (GO) - Biological Process for AQP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006833 water transport TAS --
GO:0051260 protein homooligomerization IEA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with AQP11: view

No data available for SIGNOR curated interactions for AQP11 Gene

Drugs & Compounds for AQP11 Gene

No Compound Related Data Available

Transcripts for AQP11 Gene

mRNA/cDNA for AQP11 Gene

Unigene Clusters for AQP11 Gene

Aquaporin 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AQP11 Gene

No ASD Table

Relevant External Links for AQP11 Gene

GeneLoc Exon Structure for
AQP11
ECgene alternative splicing isoforms for
AQP11

Expression for AQP11 Gene

mRNA expression in normal human tissues for AQP11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AQP11 Gene

This gene is overexpressed in Adrenal Gland (x7.0) and Liver (x4.0).

Protein differential expression in normal tissues from HIPED for AQP11 Gene

This gene is overexpressed in Fetal ovary (28.1), Fetal testis (12.3), Retina (7.4), and Fetal Liver (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for AQP11 Gene



SOURCE GeneReport for Unigene cluster for AQP11 Gene Hs.503345

genes like me logo Genes that share expression patterns with AQP11: view

Protein tissue co-expression partners for AQP11 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for AQP11 Gene

Orthologs for AQP11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AQP11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AQP11 35
  • 88.85 (n)
  • 85.21 (a)
AQP11 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AQP11 35
  • 88.81 (n)
  • 84.87 (a)
AQP11 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aqp11 35
  • 85.36 (n)
  • 83.03 (a)
Aqp11 16
Aqp11 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AQP11 35
  • 99.38 (n)
  • 98.52 (a)
AQP11 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aqp11 35
  • 84.87 (n)
  • 81.92 (a)
oppossum
(Monodelphis domestica)
Mammalia AQP11 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AQP11 36
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves AQP11 35
  • 55.51 (n)
  • 40.94 (a)
AQP11 36
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AQP11 36
  • 39 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii aqp11 35
  • 48.9 (n)
  • 37.35 (a)
aqp11 36
  • 33 (a)
ManyToMany
Species with no ortholog for AQP11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AQP11 Gene

ENSEMBL:
Gene Tree for AQP11 (if available)
TreeFam:
Gene Tree for AQP11 (if available)

Paralogs for AQP11 Gene

Paralogs for AQP11 Gene

(2) SIMAP similar genes for AQP11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AQP11: view

Variants for AQP11 Gene

Sequence variations from dbSNP and Humsavar for AQP11 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2276415 - 77,590,296(+) CGTGC(A/G)GCGTG nc-transcript-variant, reference, missense
rs713083 -- 77,602,538(+) TGAAT(A/G)TGAAT intron-variant
rs1540178 -- 77,596,622(+) gggac(A/G)tcaag intron-variant
rs1970749 -- 77,604,946(+) cccag(C/T)acttt intron-variant
rs2032395 -- 77,603,458(+) AGAAT(A/G)CCTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AQP11 Gene

Variant ID Type Subtype PubMed ID
nsv468641 CNV Gain 19166990

Variation tolerance for AQP11 Gene

Residual Variation Intolerance Score: 55.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.11; 80.55% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for AQP11 Gene

Disorders for AQP11 Gene

Relevant External Links for AQP11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AQP11

No disorders were found for AQP11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AQP11 Gene

Publications for AQP11 Gene

  1. Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule. (PMID: 16107722) Morishita Y. … Ishibashi K. (Mol. Cell. Biol. 2005) 2 3 67
  2. Human aquaporin-11 is a water and glycerol channel and localizes in the vicinity of lipid droplets in human adipocytes. (PMID: 24845055) Madeira A. … Soveral G. (Obesity (Silver Spring) 2014) 3
  3. In silico study of human aquaporin AQP11 and AQP12 channels. (PMID: 23359558) Calvanese L. … Oliva R. (Protein Sci. 2013) 3
  4. Weight loss after gastric bypass is associated with a variant at 15q26.1. (PMID: 23643386) Hatoum I.J. … Kaplan L.M. (Am. J. Hum. Genet. 2013) 3
  5. The NPC motif of aquaporin-11, unlike the NPA motif of known aquaporins, is essential for full expression of molecular function. (PMID: 21118806) Ikeda M. … Ishibashi K. (J. Biol. Chem. 2011) 3

Products for AQP11 Gene

Sources for AQP11 Gene

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