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AQP11 Gene

protein-coding   GIFtS: 51
GCID: GC11P077300

Aquaporin 11

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Aquaporin 111 2
AQPX12 3 5
AQP-112 3
aquaporin-112

External Ids:    HGNC: 199401   Entrez Gene: 2826792   Ensembl: ENSG000001783017   OMIM: 6099145   UniProtKB: Q8NBQ73   
ORGUL members:         

Export aliases for AQP11 gene to outside databases

Previous GC identifers: GC11M078840 GC11P077523 GC11P077027 GC11P077028 GC11P076978 GC11P073599


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for AQP11 Gene:
AQP11 (aquaporin 11) is a protein-coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is AQP12B.

UniProtKB/Swiss-Prot: AQP11_HUMAN, Q8NBQ7
Function: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the AQP11 gene promoter:
         STAT5B   USF1   Sox5   XBP-1   MIF-1   C/EBPalpha   Max   USF-1   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAQP11 promoter sequence
   Search Chromatin IP Primers for AQP11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AQP11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.1   Ensembl cytogenetic band:  11q14.1   HGNC cytogenetic band: 11q13.5

AQP11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AQP11 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P077300:  view genomic region     (about GC identifiers)

Start:
77,300,436 bp from pter      End:
77,321,401 bp from pter
Size:
20,966 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AQP11_HUMAN, Q8NBQ7 (See protein sequence)
Recommended Name: Aquaporin-11  
Size: 271 amino acids; 30203 Da

Explore the universe of human proteins at neXtProt for AQP11: NX_Q8NBQ7

Explore proteomics data for AQP11 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn264

  • See AQP11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_766627.1  
    ENSEMBL proteins: 
     ENSP00000318770  
    Reactome Protein details: Q8NBQ7

    AQP11 Human Recombinant Protein Products:

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    antibodies-online kits for AQP11 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AQP: Ion channels / Aquaporins

    4 InterPro protein domains:
     IPR016697 Aquaporin_11/12
     IPR023271 Aquaporin-like
     IPR000425 MIP
     IPR023266 Aquaporin_11

    Graphical View of Domain Structure for InterPro Entry Q8NBQ7

    ProtoNet protein and cluster: Q8NBQ7

    1 Blocks protein domain: IPB000425 MIP family

    UniProtKB/Swiss-Prot: AQP11_HUMAN, Q8NBQ7
    Domain: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming
    loop with the signature motif Asn-Pro-Ala (NPA)
    Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily


    Find genes that share domains with AQP11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AQP11_HUMAN, Q8NBQ7
    Function: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes (By
    similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005215transporter activity IEA--
    GO:0015250water channel activity ----
         
    Find genes that share ontologies with AQP11           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Aqp11):
     cellular  growth/size/body  homeostasis/metabolism  liver/biliary system  mortality/aging 
     renal/urinary system 

    Find genes that share phenotypes with AQP11           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Aqp11tm1Lex for AQP11

       genOway: Develop your customized and physiologically relevant rodent model for AQP11

    miRNA
    Products:
        
    miRTarBase miRNAs that target AQP11:
    hsa-mir-375 (MIRT019715)

    Block miRNA regulation of human, mouse, rat AQP11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AQP11 (see all 36):
    hsa-miR-3607-3p hsa-miR-15a hsa-miR-503 hsa-miR-4267 hsa-miR-374c hsa-miR-424 hsa-miR-15b hsa-miR-1294
    SwitchGear 3'UTR luciferase reporter plasmidAQP11 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat AQP11

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AQP11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AQP11_HUMAN, Q8NBQ7: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol2
    endoplasmic reticulum2
    endosome1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005783endoplasmic reticulum IEA--
    GO:0005829cytosol IEA--
    GO:0005886plasma membrane TAS--
    GO:0009986cell surface IDA16650285

    Find genes that share ontologies with AQP11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AQP11 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of Water Balance by Renal Aquaporins
    Aquaporin-mediated transport0.85
    Passive Transport by Aquaporins0.00
    2Nanog in Mammalian ESC Pluripotency
    eNOS Signaling0.48
    3Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47


    Find genes that share SuperPaths with AQP11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for AQP11
        eNOS Signaling

    1 Reactome Pathway for AQP11
        Passive transport by Aquaporins


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AQP11
    Interactions:

        Search GeneGlobe Interaction Network for AQP11

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for AQP11 (ENSP000003187704) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STAT5AENSP000003412084STRING: ENSP00000341208
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001822kidney development ----
    GO:0006810transport ----
    GO:0006811NOT ion transport IDA16650285
    GO:0006833water transport TAS--
    GO:0015793NOT glycerol transport IDA16650285

    Find genes that share ontologies with AQP11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AQP11



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for AQP11 gene: 
    NM_173039.2  

    Unigene Cluster for AQP11:

    Aquaporin 11
    Hs.503345  [show with all ESTs]
    Unigene Representative Sequence: NM_173039
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528638 ENST00000313578(uc009yuu.3 uc001oyj.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat AQP11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate AQP11 (see all 36):
    hsa-miR-3607-3p hsa-miR-15a hsa-miR-503 hsa-miR-4267 hsa-miR-374c hsa-miR-424 hsa-miR-15b hsa-miR-1294
    SwitchGear 3'UTR luciferase reporter plasmidAQP11 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat AQP11
      QuantiFast Probe-based Assays in human, mouse, rat AQP11

    Additional mRNA sequence: 

    AB028147.1 AK075346.1 AK311096.1 BC040443.1 

    3 DOTS entries:

    DT.100018577  DT.97769364  DT.91755985 

    Selected AceView cDNA sequences (see all 29):

    AI261193 AK075346 H92059 NM_173039 BC040443 AI886656 AA843769 BX101015 
    CA868496 AA322527 AI471857 AW298217 AI371809 AB028147 BG202356 AI807380 
    BG204427 BQ025213 AW901175 BG182704 BG192631 W26419 BF510177 BF510172 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AQP11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    AQP11 Expression
    About this image


    AQP11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Kidney (Urinary System)
             Ureteric Bud
    AQP11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AQP11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.503345
        Custom PCR Arrays for AQP11
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for AQP11 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aqp111 , 5 aquaporin 111, 5 85.36(n)1
    83.03(a)1
      7 (53.57 cM)5
    663331  NM_175105.31  NP_780314.11 
     977263795 
    chicken
    (Gallus gallus)
    Aves AQP111 aquaporin 11 55.51(n)
    40.94(a)
      426725  XM_004938939.1  XP_004938996.1 
    lizard
    (Anolis carolinensis)
    Reptilia AQP116
    aquaporin 11
    39(a)
    1 ↔ 1
    GL343337.1(750792-759810)
    zebrafish
    (Danio rerio)
    Actinopterygii aqp111 aquaporin 11 48.9(n)
    37.35(a)
      553476  XM_001921633.4  XP_001921668.3 


    ENSEMBL Gene Tree for AQP11 (if available)
    TreeFam Gene Tree for AQP11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for AQP11 gene
    AQP12B2  AQP12A2  
    2 SIMAP similar genes for AQP11 using alignment to 1 protein entry:     AQP11_HUMAN:
    AQP12A    AQP12B

    Find genes that share paralogs with AQP11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for AQP11 (see all 432)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1118893881,2
    C--77298815(+) TAGTCT/CCAGCT 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1397273721,2
    --77298855(+) TGAACC/GCGGGA 1 -- us2k10--------
    rs1133778451,2
    C--77298886(+) AGATCG/ACGCCA 1 -- us2k11Minor allele frequency- A:0.00CSA 1
    rs1822739221,2
    --77298917(+) CAGAGC/TGAGAC 1 -- us2k10--------
    rs1861494701,2
    --77298938(+) AAAAAA/TAATAA 1 -- us2k10--------
    rs1892022261,2
    C--77299000(+) AAGAGA/GAAAGG 1 -- us2k10--------
    rs1166637561,2
    F--77299007(+) AAGGTC/TTTGAT 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1815329541,2
    C--77299277(+) TTATCC/TGCCTG 1 -- us2k10--------
    rs1858900821,2
    --77299351(+) GAATGC/TGGTGG 1 -- us2k10--------
    rs1913847111,2
    --77299357(+) GGTGGC/TAAGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for AQP11 (77300436 - 77321401 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for AQP11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv468641CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AQP11
    DNA2.0 Custom Variant and Variant Library Synthesis for AQP11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609914    OMIM disorders: --


    Find genes that share disorders with AQP11           About GenesLikeMe


    Export disorders for AQP11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AQP11 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with AQP11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule. (PubMed id 16107722)1, 3 Morishita Y....Ishibashi K. (Mol. Cell. Biol. 2005)
    2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. In silico study of human aquaporin AQP11 and AQP12 channels. (PubMed id 23359558)1 Calvanese L....Oliva R. (Protein Sci. 2013)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Weight loss after gastric bypass is associated with a variant at 15q26.1. (PubMed id 23643386)1 Hatoum I.J....Kaplan L.M. (Am. J. Hum. Genet. 2013)
    7. The NPC motif of aquaporin-11, unlike the NPA motif of known aquaporins, is essential for full expression of molecular function. (PubMed id 21118806)1 Ikeda M....Ishibashi K. (J. Biol. Chem. 2011)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    10. Aquaporin-11: a channel protein lacking apparent transport function expressed in brain. (PubMed id 16650285)1 Gorelick D.A....Agre P. (BMC Biochem. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 282679 HGNC: 19940 AceView: AQP11 Ensembl:ENSG00000178301 euGenes: HUgn282679
    ECgene: AQP11 H-InvDB: AQP11

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AQP11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AQP11 gene:
    Search GeneIP for patents involving AQP11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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