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AQP11 Gene(Protein Coding)

Aquaporin 11

GCID:
GC11P077589
GIFtS:
50
Genes Participants
UDN Logo

Aliases for AQP11 Gene

Aliases for AQP11 Gene

  • Aquaporin 11 2 3 5
  • AQP-11 3 4
  • AQPX1 3 4
  • Aquaporin-11 3

External Ids for AQP11 Gene

Previous GeneCards Identifiers for AQP11 Gene

  • GC11M078840
  • GC11P077523
  • GC11P077027
  • GC11P077028
  • GC11P076978
  • GC11P077300
  • GC11P073599

Summaries for AQP11 Gene

GeneCards Summary for AQP11 Gene

AQP11 (Aquaporin 11) is a Protein Coding gene. Among its related pathways are Aquaporin-mediated transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity and water channel activity. An important paralog of this gene is AQP12B.

UniProtKB/Swiss-Prot for AQP11 Gene

  • Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.

Tocris Summary for AQP11 Gene

  • Aquaporins (AQPs) are integral membrane proteins that facilitate the transport of water across biological membranes along an osmotic gradient. There have been 13 AQP isoforms (AQP0-AQP12) identified in humans and rodents to date.

No data available for Entrez Gene Summary , CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AQP11 Gene

Genomics for AQP11 Gene

Products:

  1. Regulatory Element

Regulatory Elements for AQP11 Gene

Enhancers for AQP11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G077444 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10 -143.7 -143693 1.6 HNRNPUL1 MTA2 DPF2 ATF2 TBX21 ZNF664 ARID3A IKZF1 NBN SPI1 PAK1 GDPD4 AQP11 ENSG00000268635 GC11P077330
GH11G077630 1.2 Ensembl ENCODE 11.2 +41.6 41575 1.6 PKNOX1 FOXA2 MLX ARID4B DMAP1 YY1 JUNB TBX21 KAT8 MIER3 CLNS1A INTS4 AQP11 GC11P077629
GH11G077469 1.3 ENCODE dbSUPER 10 -116.6 -116628 7.4 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 CBX5 FOS KLF13 ZNF263 PAK1 GDPD4 RSF1 AQP11 MYO7A ENSG00000268635 GC11P077330
GH11G077557 1.1 Ensembl ENCODE 11.1 -29.5 -29523 4.7 RAD21 GATA2 ZNF366 RCOR1 FOS SMARCC1 USF2 CEBPB ZEB2 MAFF AQP11 MYO7A AAMDC INTS4 CLNS1A GC11M077567 GC11M077551
GH11G077588 1.4 Ensembl ENCODE 8.5 +1.0 1001 4.0 HDGF FOXA2 PKNOX1 MLX AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B AAMDC CLNS1A INTS4 GDPD4 AQP11 GC11M077568
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AQP11 on UCSC Golden Path with GeneCards custom track

Promoters for AQP11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000264999 209 1201 HDGF FOXA2 PKNOX1 MLX AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B
ENSR00000042474 1409 400 ELF3 CTCF CTBP1 SCRT2 CREB1 ZSCAN29 ZBTB33 RCOR1

Transcription factor binding sites by QIAGEN in the AQP11 gene promoter:

Genomic Location for AQP11 Gene

Chromosome:
11
Start:
77,589,391 bp from pter
End:
77,610,356 bp from pter
Size:
20,966 bases
Orientation:
Plus strand

Genomic View for AQP11 Gene

Genes around AQP11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AQP11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AQP11 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for AQP11 Gene

Proteins for AQP11 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for AQP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBQ7-AQP11_HUMAN
    Recommended name:
    Aquaporin-11
    Protein Accession:
    Q8NBQ7

    Protein attributes for AQP11 Gene

    Size:
    271 amino acids
    Molecular mass:
    30203 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AQP11 Gene

Protein Expression for AQP11 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for AQP11 Gene

Other Protein References for AQP11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AQP11 Gene

Domains & Families for AQP11 Gene

Gene Families for AQP11 Gene

HGNC:

Protein Domains for AQP11 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for AQP11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NBQ7

UniProtKB/Swiss-Prot:

AQP11_HUMAN :
  • Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
  • Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
Domain:
  • Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Family:
  • Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
genes like me logo Genes that share domains with AQP11: view

Function for AQP11 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for AQP11 Gene

UniProtKB/Swiss-Prot Function:
Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.

Gene Ontology (GO) - Molecular Function for AQP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005215 transporter activity IEA --
genes like me logo Genes that share ontologies with AQP11: view
genes like me logo Genes that share phenotypes with AQP11: view

Animal Models for AQP11 Gene

MGI Knock Outs for AQP11:

Animal Model Products

  • Taconic Biosciences Mouse Models for AQP11

CRISPR Products

miRNA for AQP11 Gene

miRTarBase miRNAs that target AQP11

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AQP11 Gene

Localization for AQP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AQP11 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AQP11 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 3
cytosol 2
endosome 1

Gene Ontology (GO) - Cellular Components for AQP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IDA 16650285
genes like me logo Genes that share ontologies with AQP11: view

Pathways & Interactions for AQP11 Gene

genes like me logo Genes that share pathways with AQP11: view

Pathways by source for AQP11 Gene

1 Qiagen pathway for AQP11 Gene

Interacting Proteins for AQP11 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000318770%0d%0a9606.ENSP00000228280%0d%0a
Selected Interacting proteins: Q8NBQ7-AQP11_HUMAN ENSP00000318770 for AQP11 Gene via IID STRING

Gene Ontology (GO) - Biological Process for AQP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 NOT ion transport IDA 16650285
GO:0006833 NOT water transport IDA 16650285
GO:0015793 NOT glycerol transport IDA 16650285
GO:0015840 NOT urea transport IDA 16650285
genes like me logo Genes that share ontologies with AQP11: view

No data available for SIGNOR curated interactions for AQP11 Gene

Drugs & Compounds for AQP11 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for AQP11 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for AQP11 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AQP11 Gene

Aquaporin 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AQP11 Gene

No ASD Table

Relevant External Links for AQP11 Gene

GeneLoc Exon Structure for
AQP11
ECgene alternative splicing isoforms for
AQP11

Expression for AQP11 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AQP11 Gene

mRNA expression in normal human tissues for AQP11 Gene
mRNA expression by BioGPS for AQP11 GenemRNA expression by GTEx for AQP11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AQP11 Gene

This gene is overexpressed in Adrenal Gland (x7.0) and Liver (x4.0).

Protein differential expression in normal tissues from HIPED for AQP11 Gene

This gene is overexpressed in Fetal ovary (28.1), Fetal testis (12.3), Retina (7.4), and Fetal Liver (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AQP11 Gene



Protein tissue co-expression partners for AQP11 Gene

NURSA nuclear receptor signaling pathways regulating expression of AQP11 Gene:

AQP11

SOURCE GeneReport for Unigene cluster for AQP11 Gene:

Hs.503345

Evidence on tissue expression from TISSUES for AQP11 Gene

  • Nervous system(4.3)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with AQP11: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for AQP11 Gene

Orthologs for AQP11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AQP11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia AQP11 34 35
  • 99.38 (n)
cow
(Bos Taurus)
 Mammalia AQP11 34 35
  • 88.85 (n)
dog
(Canis familiaris)
 Mammalia AQP11 34 35
  • 88.81 (n)
mouse
(Mus musculus)
 Mammalia Aqp11 34 16 35
  • 85.36 (n)
rat
(Rattus norvegicus)
 Mammalia Aqp11 34
  • 84.87 (n)
oppossum
(Monodelphis domestica)
 Mammalia AQP11 35
  • 56 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia AQP11 35
  • 48 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves AQP11 34 35
  • 55.51 (n)
lizard
(Anolis carolinensis)
 Reptilia AQP11 35
  • 39 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii aqp11 34 35
  • 48.9 (n)
Species where no ortholog for AQP11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AQP11 Gene

ENSEMBL:
Gene Tree for AQP11 (if available)
TreeFam:
Gene Tree for AQP11 (if available)

Paralogs for AQP11 Gene

Paralogs for AQP11 Gene

(2) SIMAP similar genes for AQP11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AQP11: view

Variants for AQP11 Gene

Sequence variations from dbSNP and Humsavar for AQP11 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000024994 -- 77,598,861(+) AGGTG(C/T)CTGCC intron-variant
rs1000133664 -- 77,606,340(+) ACGAT(A/G)GATAA intron-variant
rs1000305515 -- 77,606,064(+) AAAAA(G/T)CACAG intron-variant
rs1000380703 -- 77,607,122(+) TGTAT(A/G)TGAAT intron-variant
rs1000533300 -- 77,593,911(+) CTACA(A/C)CATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AQP11 Gene

Variant ID Type Subtype PubMed ID
dgv1234n100 CNV gain 25217958
esv3626887 CNV loss 21293372
nsv468641 CNV gain 19166990
nsv555452 CNV gain 21841781

Variation tolerance for AQP11 Gene

Residual Variation Intolerance Score: 55.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.11; 80.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AQP11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AQP11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AQP11 Gene

Disorders for AQP11 Gene

Relevant External Links for AQP11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AQP11

No disorders were found for AQP11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AQP11 Gene

Publications for AQP11 Gene

  1. Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule. (PMID: 16107722) Morishita Y. … Ishibashi K. (Mol. Cell. Biol. 2005) 2 3 64
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Aquaporin-Mediated Water and Hydrogen Peroxide Transport Is Involved in Normal Human Spermatozoa Functioning. (PMID: 28042826) Laforenza U. … Gastaldi G. (Int J Mol Sci 2016) 3 64
  5. Aquaporin 11 variant associates with kidney disease in type 2 diabetic patients. (PMID: 26719361) Choma D.P. … Tchekneva E.E. (Am. J. Physiol. Renal Physiol. 2016) 3 64

Products for AQP11 Gene

Sources for AQP11 Gene

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