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Aliases for AQP11 Gene

Aliases for AQP11 Gene

  • Aquaporin 11 2 3
  • AQPX1 3 4 6
  • AQP-11 3 4
  • Aquaporin-11 3

External Ids for AQP11 Gene

Previous GeneCards Identifiers for AQP11 Gene

  • GC11M078840
  • GC11P077027
  • GC11P077028
  • GC11P076978
  • GC11P077300
  • GC11P073599

Summaries for AQP11 Gene

GeneCards Summary for AQP11 Gene

AQP11 (Aquaporin 11) is a Protein Coding gene. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity. An important paralog of this gene is AQP12A.

UniProtKB/Swiss-Prot for AQP11 Gene

  • Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.

Tocris Summary for AQP11 Gene

  • Aquaporins (AQPs)are integral membrane proteins that facilitate the transport of water across biological membranes along an osmotic gradient. There have been 13 AQP isoforms (AQP0-AQP12) identified in humans and rodents to date.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AQP11 Gene

Genomics for AQP11 Gene

Regulatory Elements for AQP11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AQP11 Gene

Start:
77,589,391 bp from pter
End:
77,610,356 bp from pter
Size:
20,966 bases
Orientation:
Plus strand

Genomic View for AQP11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AQP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AQP11 Gene

Proteins for AQP11 Gene

  • Protein details for AQP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBQ7-AQP11_HUMAN
    Recommended name:
    Aquaporin-11
    Protein Accession:
    Q8NBQ7
    Secondary Accessions:

    Protein attributes for AQP11 Gene

    Size:
    271 amino acids
    Molecular mass:
    30203 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AQP11 Gene

Proteomics data for AQP11 Gene at MOPED

Post-translational modifications for AQP11 Gene

Other Protein References for AQP11 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for AQP11 Gene

Domains for AQP11 Gene

Gene Families for AQP11 Gene

HGNC:
  • AQP :Ion channels / Aquaporins

Protein Domains for AQP11 Gene

Suggested Antigen Peptide Sequences for AQP11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NBQ7

UniProtKB/Swiss-Prot:

AQP11_HUMAN :
  • Q8NBQ7
Domain:
  • Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)
Family:
  • Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
genes like me logo Genes that share domains with AQP11: view

Function for AQP11 Gene

Molecular function for AQP11 Gene

UniProtKB/Swiss-Prot Function:
Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.

Gene Ontology (GO) - Molecular Function for AQP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005215 transporter activity IEA --
GO:0015250 water channel activity --
genes like me logo Genes that share ontologies with AQP11: view
genes like me logo Genes that share phenotypes with AQP11: view

Animal Models for AQP11 Gene

MGI Knock Outs for AQP11:

Animal Model Products

miRNA for AQP11 Gene

miRTarBase miRNAs that target AQP11

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AQP11

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for AQP11 Gene

Localization for AQP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AQP11 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AQP11 Gene COMPARTMENTS Subcellular localization image for AQP11 gene
Compartment Confidence
plasma membrane 4
cytosol 2
endoplasmic reticulum 2
endosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for AQP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IDA 16650285
genes like me logo Genes that share ontologies with AQP11: view

Pathways for AQP11 Gene

genes like me logo Genes that share pathways with AQP11: view

Pathways by source for AQP11 Gene

Interacting Proteins for AQP11 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000318770%0d%0a9606.ENSP00000341208%0d%0a
Selected Interacting proteins: ENSP00000318770 for AQP11 Gene via STRING

Symbol External ID(s) Details
STAT5A

Gene Ontology (GO) - Biological Process for AQP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development --
GO:0006810 transport --
GO:0006811 NOT ion transport IDA 16650285
GO:0006833 water transport TAS --
GO:0015793 NOT glycerol transport IDA 16650285
genes like me logo Genes that share ontologies with AQP11: view

Transcripts for AQP11 Gene

mRNA/cDNA for AQP11 Gene

Unigene Clusters for AQP11 Gene

Aquaporin 11:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AQP11

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AQP11 Gene

No ASD Table

Relevant External Links for AQP11 Gene

GeneLoc Exon Structure for
AQP11
ECgene alternative splicing isoforms for
AQP11

Expression for AQP11 Gene

mRNA expression in normal human tissues for AQP11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AQP11 Gene

This gene is overexpressed in Adrenal Gland (7.0) and Liver (4.0).

Protein differential expression in normal tissues for AQP11 Gene

This gene is overexpressed in Fetal ovary (28.1), Fetal testis (12.3), Retina (7.4), and Fetal Liver (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AQP11 Gene

SOURCE GeneReport for Unigene cluster for AQP11 Gene Hs.503345

genes like me logo Genes that share expressions with AQP11: view

Expression partners for AQP11 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for AQP11 Gene

Orthologs for AQP11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for AQP11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AQP11 35
  • 88.85 (n)
  • 85.21 (a)
AQP11 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AQP11 35
  • 88.81 (n)
  • 84.87 (a)
AQP11 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aqp11 35
  • 85.36 (n)
  • 83.03 (a)
Aqp11 16
Aqp11 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AQP11 35
  • 99.38 (n)
  • 98.52 (a)
AQP11 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aqp11 35
  • 84.87 (n)
  • 81.92 (a)
oppossum
(Monodelphis domestica)
Mammalia AQP11 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AQP11 36
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves AQP11 35
  • 55.51 (n)
  • 40.94 (a)
AQP11 36
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AQP11 36
  • 39 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii aqp11 35
  • 48.9 (n)
  • 37.35 (a)
aqp11 36
  • 33 (a)
ManyToMany
Species with no ortholog for AQP11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AQP11 Gene

ENSEMBL:
Gene Tree for AQP11 (if available)
TreeFam:
Gene Tree for AQP11 (if available)

Paralogs for AQP11 Gene

Paralogs for AQP11 Gene

Selected SIMAP similar genes for AQP11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AQP11: view

Variants for AQP11 Gene

Sequence variations from dbSNP and Humsavar for AQP11 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs713083 -- 77,602,538(+) TGAAT(A/G)TGAAT intron-variant
rs1540178 -- 77,596,622(+) gggac(A/G)tcaag intron-variant
rs1970749 -- 77,604,946(+) cccag(C/T)acttt intron-variant
rs2032395 -- 77,603,458(+) AGAAT(A/G)CCTAA intron-variant
rs2276415 - 77,590,296(+) CGTGC(A/G)GCGTG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for AQP11 Gene

Variant ID Type Subtype PubMed ID
nsv468641 CNV Gain 19166990

Relevant External Links for AQP11 Gene

HapMap Linkage Disequilibrium report
AQP11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AQP11 Gene

Disorders for AQP11 Gene

No disorders were found for AQP11 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for AQP11 Gene

Publications for AQP11 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule. (PMID: 16107722) Morishita Y. … Ishibashi K. (Mol. Cell. Biol. 2005) 2 3
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  4. Aquaporin-11: a channel protein lacking apparent transport function expressed in brain. (PMID: 16650285) Gorelick D.A. … Agre P. (BMC Biochem. 2006) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for AQP11 Gene

Sources for AQP11 Gene

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