AQP11 Gene
protein-coding GIFtS: 45
GCID: GC11P077300
|
|
aquaporin 11
| |
Aliases
for AQP11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Aquaporin 111 2 | | AQPX12 3 5 | | AQP-112 3 | | Aquaporin-111 |
Export aliases for AQP11 gene to outside databasesPrevious GC identifers: GC11M078840 GC11P077523 GC11P077027 GC11P077028 GC11P076978 GC11P073599 |
Summaries
for AQP11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: AQP11_HUMAN, Q8NBQ7Function: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes (By similarity)
|
Genomic Views
for AQP11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the AQP11 gene promoter:
STAT5B USF1 Sox5 XBP-1 MIF-1 C/EBPalpha Max USF-1 Pax-4a c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for AQP11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AQP11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q14.1 Ensembl cytogenetic band: 11q14.1 HGNC cytogenetic band: 11q13.5AQP11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P077300: view genomic region
(about GC identifiers)
Start:
|
77,300,436 bp from pter |
End:
|
77,321,401 bp from pter |
Size:
|
20,966 bases |
Orientation:
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plus strand |
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Proteins
for AQP11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AQP11_HUMAN, Q8NBQ7 (See
protein sequence)Recommended Name: Aquaporin-11 Size: 271 amino acids; 30203 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)Explore the universe of human proteins at neXtProt for AQP11: NX_Q8NBQ7
AQP11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_766627.1
ENSEMBL proteins: ENSP00000318770 Reactome Protein details: Q8NBQ7
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
AQP11 for ontologies About GeneDecksing
AQP11 Antibody Products:
Assay Products for AQP11: |
Protein
Domains /
Families
for AQP11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
AQP11 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NBQ7ProtoNet protein and cluster: Q8NBQ7 1 Blocks protein family: IPB000425 MIP family
UniProtKB/Swiss-Prot: AQP11_HUMAN, Q8NBQ7Domain: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loopwith the signature motif Asn-Pro-Ala (NPA)Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily |
Function
for AQP11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: AQP11_HUMAN, Q8NBQ7Function: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AQP11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AQP11
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: AQP11 (NM_173039) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AQP11 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AQP11 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AQP11 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0005215 | transporter activity |
IEA | -- |
AQP11 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Aqp11tm1Lex for AQP11
4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Aqp11):
AQP11 for phenotypes About GeneDecksing
|
Pathways & Interactions
for AQP11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Passive Transport by Aquaporins | | | 2 | Regulation of Water Balance by Renal Aquaporins | | | 3 | SLC-mediated transmembrane transport | | | 4 | Nanog in Mammalian ESC Pluripotency | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for AQP11
3 
Reactome Pathways for AQP11
AQP11 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for AQP11
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for AQP11 (ENSP000003187704) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
AQP11 for ontologies About GeneDecksing
|
Drugs & Compounds
for AQP11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for AQP11
Search CenterWatch for drugs/clinical trials and news about AQP11
|
Transcripts
for AQP11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for AQP11 gene: NM_173039.2 Unigene Cluster for AQP11: Aquaporin 11 Hs.503345 [show with all ESTs]Unigene Representative Sequence: NM_1730392 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000528638 ENST00000313578(uc009yuu.3 uc001oyj.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AQP11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AQP11
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: AQP11 (NM_173039) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for AQP11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AQP11 |
Additional cDNA sequence: AB028147.1 AK075346.1 AK311096.1 BC040443.1 3 DOTS entries: DT.100018577 DT.97769364 DT.91755985 24/29 AceView cDNA sequences (see all 29): BC040443 H92059 AI261193 AK075346 AI886656 NM_173039 AA843769 AA322527 AI371809 CA868496 BX101015 AI471857 AB028147 AW298217 BG202356 AI807380 BG182704 BQ025213 BG192631 AW901175 BG204427 BF510177 BF510172 W26419
GeneLoc Exon Structure
|
Expression
for AQP11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| AQP11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See AQP11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for AQP11
SOURCE GeneReport for Unigene cluster: Hs.503345
SABiosciences Custom PCR Arrays for AQP11
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AQP11
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat AQP11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AQP11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AQP11 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AQP11 |
Orthologs
for AQP11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for AQP11 gene from 3/14 species (see all 14) About this table
ENSEMBL Gene Tree for AQP11 (if available)
TreeFam Gene Tree for AQP11 (if available) |
Paralogs
for AQP11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for AQP11 gene
- AQP12B2 AQP12A2
2 SIMAP similar genes for AQP11 using alignment to 1 protein entry: AQP11_HUMAN:AQP12A AQP12B
AQP11 for paralogs About GeneDecksing
|
Genomic Variants
for AQP11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for AQP11 (77300436 - 77321401 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for AQP11: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AQP11 |
|
Disorders
/ Diseases
for AQP11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
AQP11 for disorders About GeneDecksing
OMIM gene information: 609914
OMIM disorders: --
6  diseases for AQP11: About MalaCardsbackground diabetic retinopathy nephrogenic diabetes insipidus diabetes insipidus polycystic kidney disease
oligohydramnios kidney disease
Export disorders for AQP11 gene to outside databases
|
Publications
for AQP11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for AQP11 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with AQP11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule. (PubMed id 16107722)1, 3 Morishita Y....Ishibashi K. (2005)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The NPC motif of aquaporin-11, unlike the NPA motif o f known aquaporins, is essential for full expression of molecular function. (PubMed id 21118806)1 Ikeda M....Ishibashi K. (2011)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Aquaporin-11: a channel protein lacking apparent transport function expressed in brain. (PubMed id 16650285)1 Gorelick D.A....Agre P. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Aquaporin superfamily with unusual npa boxes: S-aquaporins (superfamily, sip-like and subcellular-aquaporins). (PubMed id 17543217)9 Ishibashi K. (2006)
- Aquaporin water channels in mammals. (PubMed id 19085041)9 Ishibashi K....Kondo S. (2009)
|
External Searches for AQP11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing AQP11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing AQP11 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing AQP11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for AQP11 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for AQP11 gene:
Search GeneIP for patents involving AQP11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for AQP11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for AQP11 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for AQP11 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for AQP11 | | | OriGene Protein Over-expression Lysate for AQP11 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for AQP11 | | OriGene 3'-UTR Clone for AQP11 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for AQP11 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for AQP11 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for AQP11 | | OriGene Custom Protein Services for AQP11 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat AQP11 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing AQP11 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat AQP11 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat AQP11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat AQP11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat AQP11 |
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 |  |  |  | |
| | | | Search Tocris compounds for AQP11 |
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 | | | AQP11 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AQP11 |
|  |  |  | | | | ThermoFisher Antibodies for AQP11 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AQP11 |
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