Aliases for AQP10 Gene
Aliases for AQP10 Gene
External Ids for AQP10 Gene
- HGNC: 16029
- Entrez Gene: 89872
- Ensembl: ENSG00000143595
- OMIM: 606578
- UniProtKB: Q96PS8
Previous GeneCards Identifiers for AQP10 Gene
- GC01P152110
- GC01P150024
- GC01P151068
- GC01P151510
- GC01P151106
- GC01P152560
- GC01P154294
- GC01P125657
Summaries for AQP10 Gene
-
This gene encodes a member of the aquaglyceroporin family of integral membrane proteins. Members of this family function as water-permeable channels in the epithelia of organs that absorb and excrete water. This protein was shown to function as a water-selective channel, and could also permeate neutral solutes such as glycerol and urea. [provided by RefSeq, Jul 2008]
GeneCards Summary for AQP10 Gene
AQP10 (Aquaporin 10) is a Protein Coding gene. Among its related pathways are Aquaporin-mediated transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity and glycerol channel activity. An important paralog of this gene is AQP9.
UniProtKB/Swiss-Prot for AQP10 Gene
-
Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol.
-
Aquaporins (AQPs) are integral membrane proteins that facilitate the transport of water across biological membranes along an osmotic gradient. There have been 13 AQP isoforms (AQP0-AQP12) identified in humans and rodents to date.
No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AQP10 Gene
Genomics for AQP10 Gene
Regulatory Elements for AQP10 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH01G154320 | 1.3 | ENCODE dbSUPER | 6.7 | +0.4 | 389 | 1.8 | PKNOX1 ATF1 CREB3L1 ARNT ARID4B SIN3A ZNF48 TCF12 ZNF766 CBX5 | NUP210L S100A4 ATP8B2 AQP10 RAB13 |
| GH01G154312 | 0.9 | dbSUPER | 0.4 | -8.4 | -8401 | 0.7 | HDAC1 YBX3 HDGF ATF1 ARNT YBX1 NFXL1 ZBTB40 TCF12 GATA2 | UBE2Q1 S100A4 RNU7-57P ENSG00000201129 UBAP2L MIR190B TPM3 C1orf189 UBE2Q1-AS1 ADAR |
| GH01G154313 | 0.9 | dbSUPER | 0.4 | -8.1 | -8140 | 1.5 | HDAC1 YBX3 HDGF ATF1 ARNT YBX1 NFXL1 ZBTB40 TCF12 GATA2 | UBE2Q1 S100A4 RNU7-57P ENSG00000201129 UBAP2L MIR190B TPM3 C1orf189 UBE2Q1-AS1 ADAR |
Regulatory Element Products
Genomic Location for AQP10 Gene
- Chromosome:
- 1
- Start:
- 154,321,067 bp from pter
- End:
- 154,325,325 bp from pter
- Size:
- 4,259 bases
- Orientation:
- Plus strand
Genomic View for AQP10 Gene
- Cytogenetic band:
-
- 1q21.3 by Ensembl
- 1q21.3 by Entrez Gene
- 1q21.3 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AQP10 Gene
Proteins for AQP10 Gene
-
Protein details for AQP10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96PS8-AQP10_HUMAN
- Recommended name:
- Aquaporin-10
- Protein Accession:
- Q96PS8
- Q5VYD3
- Q5VYD4
- Q8NG70
Protein attributes for AQP10 Gene
- Size:
- 301 amino acids
- Molecular mass:
- 31763 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for AQP10 Gene
Other Protein References for AQP10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
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- antibodies-online Antibodies for AQP10: See all 33
- GeneTex AQP10 antibody for AQP10
Protein Products
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Assay Products
- antibodies-online Kits for AQP10: See all 1
No data available for DME Specific Peptides for AQP10 Gene
Domains & Families for AQP10 Gene
Gene Families for AQP10 Gene
- HGNC:
- IUPHAR :
Protein Domains for AQP10 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for AQP10 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96PS8UniProtKB/Swiss-Prot:
AQP10_HUMAN :- Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
- Belongs to the MIP/aquaporin (TC 1.A.8) family.
- Domain:
-
- Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
- Family:
-
- Belongs to the MIP/aquaporin (TC 1.A.8) family.
Function for AQP10 Gene
Molecular function for AQP10 Gene
- UniProtKB/Swiss-Prot Function:
- Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0015250 | water channel activity | EXP | 1373524 |
| GO:0015254 | glycerol channel activity | EXP | 9369468 |
| GO:0015265 | urea channel activity | EXP | 10564231 |
Phenotypes for AQP10 Gene
- GenomeRNAi human phenotypes for AQP10:
Animal Model Products
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-
-
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-
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CRISPR Products
-
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-
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miRNA for AQP10 Gene
- miRTarBase miRNAs that target AQP10
miRNA Products
- Search ViGene Biosciences for AQP10
Inhibitory RNA Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for AQP10
-
ViGene Biosciences adenoviral particle packaged cDNA for AQP10 gene
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AQP10 Gene
Localization for AQP10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for AQP10 Gene
- Membrane; Multi-pass membrane protein.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for AQP10 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Aquaporin-mediated transport | ||
| 2 | Nanog in Mammalian ESC Pluripotency |
.48
|
|
| 3 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||
Pathways by source for AQP10 Gene
3 Reactome pathways for AQP10 Gene
1 Qiagen pathway for AQP10 Gene
Interacting Proteins for AQP10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0006833 | water transport | TAS | -- |
| GO:0009636 | response to toxic substance | IDA | 17575980 |
| GO:0015793 | glycerol transport | IEA | -- |
| GO:0071918 | urea transmembrane transport | IEA | -- |
No data available for SIGNOR curated interactions for AQP10 Gene
Transcripts for AQP10 Gene
mRNA/cDNA for AQP10 Gene
- (2) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (17) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for AQP10
-
Santa Cruz Biotechnology (SCBT) CRISPR for AQP10
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miRNA Products
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Inhibitory RNA Products
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-
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Clone Products
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- VectorBuilder custom plasmid, inducible vectors for AQP10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AQP10
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||
| SP2: |
Expression for AQP10 Gene
mRNA differential expression in normal tissues according to GTEx for AQP10 Gene
NURSA nuclear receptor signaling pathways regulating expression of AQP10 Gene:
AQP10SOURCE GeneReport for Unigene cluster for AQP10 Gene:
Hs.259048mRNA Expression by UniProt/SwissProt for AQP10 Gene:
Q96PS8-AQP10_HUMANEvidence on tissue expression from TISSUES for AQP10 Gene
- Intestine(4.5)
- Lung(4)
Primer Products
-
OriGene qPCR primer pairs for AQP10
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for AQP10 Gene
Orthologs for AQP10 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | AQP10 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | AQP10 34 |
|
||
| cow (Bos Taurus) |
Mammalia | AQP10 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC686596 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | AQP10 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | AQP10 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | AQP10 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100490571 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | aqp10b 35 |
|
OneToMany | |
| aqp10a 35 |
|
OneToMany | |||
| wufj98f09 34 |
|
||||
| worm (Caenorhabditis elegans) |
Secernentea | aqp-2 34 35 |
|
||
| Y69E1A.7 36 |
|
|
|||
| M02F4.8 36 |
|
|
|||
| aqp-8 35 |
|
ManyToMany | |||
| aqp-1 35 |
|
ManyToMany | |||
| aqp-7 35 |
|
ManyToMany | |||
| aqp-3 35 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 35 |
|
OneToMany |
- Species where no ortholog for AQP10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for AQP10 Gene
(5) SIMAP similar genes for AQP10 Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for AQP10 Gene
Variants for AQP10 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000026795 | -- | 154,324,217(+) | CCCCC(A/G)TCCTT | intron-variant, upstream-variant-2KB | |
| rs1000381897 | -- | 154,324,344(+) | TGGCA(C/T)AGCCA | upstream-variant-2KB, reference, missense | |
| rs1001530885 | -- | 154,324,832(+) | CAGTG(C/T)AGGGC | upstream-variant-2KB, utr-variant-3-prime | |
| rs1001658320 | -- | 154,323,282(+) | TGACT(A/G)GCCCC | reference, missense | |
| rs1001834412 | -- | 154,325,274(+) | AGAAG(A/G)CAGTG | upstream-variant-2KB, utr-variant-3-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1078973 | CNV | deletion | 25765185 |
| nsv1142782 | CNV | deletion | 24896259 |
| nsv521887 | CNV | gain | 19592680 |
| nsv523934 | CNV | loss | 19592680 |
| nsv946406 | CNV | duplication | 23825009 |
Relevant External Links for AQP10 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- AQP10
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AQP10 Gene
Disorders for AQP10 Gene
Relevant External Links for AQP10
No disorders were found for AQP10 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AQP10 Gene
Publications for AQP10 Gene
- Cloning of a new aquaporin (AQP10) abundantly expressed in duodenum and jejunum. (PMID: 11573934) Hatakeyama S. … Yamamoto T. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 22 64
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
- Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke M.M. … Psaty B.M. (Stroke 2009) 3 46 64
- Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J. … Lambert J.C. (Mol. Psychiatry 2009) 3 46 64
- Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D. … Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008) 3 46 64
Products for AQP10 Gene
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- antibodies-online Antibodies for AQP10: See all 33
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- Horizon Cell Lines for AQP10
- Cyagen custom Knockout/knockin (KOKI) mouse models for AQP10
- VectorBuilder custom plasmid, inducible vectors for AQP10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AQP10
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for AQP10 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
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- (14) ProtoNet
- (15) Blocks
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- (26) UniGene
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- (28) RNAdb
- (29) ASD
- (30) ECgene
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- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
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- (59) MILLIPORE
- (60) miRBase
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- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
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- (69) Novus
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- (74) Cloud-Clone Corp.
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- (76) OCA
- (77) Proteopedia
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- (100) COMPARTMENTS
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