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AQP10 Gene

protein-coding   GIFtS: 55
GCID: GC01P154294

Aquaporin 10

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Aquaporin 101 2     aquaglyceroporin-102
Small Intestine Aquaporin2 3     aquaporin-102
AQP-102 3     Aquaglyceroporin-103
AQPA_HUMAN2     

External Ids:    HGNC: 160291   Entrez Gene: 898722   Ensembl: ENSG000001435957   OMIM: 6065785   UniProtKB: Q96PS83   

Export aliases for AQP10 gene to outside databases

Previous GC identifers: GC01P152110 GC01P150024 GC01P151068 GC01P151510 GC01P151106 GC01P152560 GC01P125657


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AQP10 Gene:
This gene encodes a member of the aquaglyceroporin family of integral membrane proteins. Members of this family
function as water-permeable channels in the epithelia of organs that absorb and excrete water. This protein was
shown to function as a water-selective channel, and could also permeate neutral solutes such as glycerol and
urea. (provided by RefSeq, Jul 2008)

GeneCards Summary for AQP10 Gene:
AQP10 (aquaporin 10) is a protein-coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is AQP9.

UniProtKB/Swiss-Prot: AQP10_HUMAN, Q96PS8
Function: Water channel required to promote glycerol permeability and water transport across cell membranes. May
contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and
glycerol




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the AQP10 gene promoter:
         GR   Spz1   Pax-5   GR-beta   Sox9   GR-alpha   NF-Y   Pax-4a   CBF(2)   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAQP10 promoter sequence
   Search Chromatin IP Primers for AQP10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AQP10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.3

AQP10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AQP10 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P154294:  view genomic region     (about GC identifiers)

Start:
154,293,566 bp from pter      End:
154,297,801 bp from pter
Size:
4,236 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AQP10_HUMAN, Q96PS8 (See protein sequence)
Recommended Name: Aquaporin-10  
Size: 301 amino acids; 31763 Da
Secondary accessions: Q5VYD3 Q5VYD4 Q8NG70
Alternative splicing: 2 isoforms:  Q96PS8-1   Q96PS8-2   

Explore the universe of human proteins at neXtProt for AQP10: NX_Q96PS8

REFSEQ proteins: NP_536354.2  
ENSEMBL proteins: 
 ENSP00000318355   ENSP00000420341  
Reactome Protein details: Q96PS8

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antibodies-online kits for AQP10 (2 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
AQP: Ion channels / Aquaporins

IUPHAR Guide to PHARMACOLOGY protein family classification: AQP10
Aquaporins

4 InterPro protein domains:
 IPR023271 Aquaporin-like
 IPR000425 MIP
 IPR022357 MIP_CS
 IPR026252 Aquaporin_10

Graphical View of Domain Structure for InterPro Entry Q96PS8

ProtoNet protein and cluster: Q96PS8

1 Blocks protein domain: IPB000425 MIP family

UniProtKB/Swiss-Prot: AQP10_HUMAN, Q96PS8
Domain: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming
loop with the signature motif Asn-Pro-Ala (NPA)
Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family


Find genes that share domains with AQP10           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: AQP10_HUMAN, Q96PS8
Function: Water channel required to promote glycerol permeability and water transport across cell membranes. May
contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and
glycerol

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005215transporter activity IEA--
     
Find genes that share ontologies with AQP10           About GenesLikeMe


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AQP10
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miRNA
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miRTarBase miRNAs that target AQP10:
hsa-mir-335-5p (MIRT018828)

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1 qRT-PCR Assays for microRNA that regulate AQP10:
hsa-miR-4328
SwitchGear 3'UTR luciferase reporter plasmidAQP10 3' UTR sequence
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
AQP10_HUMAN, Q96PS8: Membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane4

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016020membrane ----
GO:0016021integral component of membrane IEA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for AQP10 About    
See pathways by source

SuperPathContained pathways About
1Regulation of Water Balance by Renal Aquaporins
Aquaporin-mediated transport0.85
Passive Transport by Aquaporins0.00
2Nanog in Mammalian ESC Pluripotency
eNOS Signaling0.48
3Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Transmembrane transport of small molecules0.47


Find genes that share SuperPaths with AQP10           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for AQP10
    eNOS Signaling

1 Reactome Pathway for AQP10
    Passive transport by Aquaporins


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for AQP10
Interactions:

    Search GeneGlobe Interaction Network for AQP10

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

Selected Interacting proteins for AQP10 (ENSP000003183554) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
InteractantInteraction Details
GeneCardExternal ID(s)
MAPK11ENSP000003336854STRING: ENSP00000333685
MAPK13ENSP000002112874STRING: ENSP00000211287
MAPK14ENSP000002297944STRING: ENSP00000229794
MAPK1ENSP000002158324STRING: ENSP00000215832
MAPK3ENSP000002630254STRING: ENSP00000263025
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Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006810transport ----
GO:0006833water transport TAS--
GO:0009636response to toxic substance IDA17575980
GO:0055085transmembrane transport TAS--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for AQP10

1 HMDB Compound for AQP10    About this table
CompoundSynonyms CAS #PubMed Ids
WaterDihydrogen oxide (see all 2)7732-18-5--

1 IUPHAR Ligand for AQP10 (AQP10)    About this table
LigandTypeActionAffinityPubmed IDs
Hg2+
InhibitorNone--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for AQP10 gene: 
NM_080429.2  

Unigene Cluster for AQP10:

Aquaporin 10
Hs.259048  [show with all ESTs]
Unigene Representative Sequence: NM_080429
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000355197 ENST00000324978(uc001feu.3) ENST00000484864
miRNA
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1 qRT-PCR Assays for microRNA that regulate AQP10:
hsa-miR-4328
SwitchGear 3'UTR luciferase reporter plasmidAQP10 3' UTR sequence
Inhib. RNA
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  QuantiFast Probe-based Assays in human, mouse, rat AQP10

Additional mRNA sequence: 

AB066105.1 AK314993.1 BC069607.1 BC074896.2 BC074897.2 

2 DOTS entries:

DT.99997911  DT.40299052 

17 AceView cDNA sequences:

BC074897 BC069607 CR614330 AF159174 BC074896 BX371346 AB066105 NM_080429 
AW592086 BX483097 BX368990 AL521579 AW665999 AA693965 AL521580 BX345560 
BX345561 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for AQP10    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1:                                          
SP2:                                          


ECgene alternative splicing isoforms for AQP10

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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AQP10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GACCCTGGAG
AQP10 Expression
About this image

AQP10 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.259048

UniProtKB/Swiss-Prot: AQP10_HUMAN, Q96PS8
Tissue specificity: Expressed exclusively in duodenum and jejunum. Highest expression in absorptive epithelial
cells at the tips of villi in the jejunum

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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for AQP10 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
rat
(Rattus norvegicus)
Mammalia LOC6865961 similar to aquaporin 10 84.42(n)
86.92(a)
  686596  XM_006232794.1  XP_006232856.1 
chicken
(Gallus gallus)
Aves AQP101 aquaporin 10 67.88(n)
65(a)
  101749384  XM_004948281.1  XP_004948338.1 
lizard
(Anolis carolinensis)
Reptilia AQP106
aquaporin 10
56(a)
1 ↔ 1
GL343805.1(141609-152650)
tropical clawed frog
(Xenopus tropicalis)
Amphibia LOC1004905711 aquaporin-10-like 62.17(n)
61.94(a)
  100490571  XM_002943358.2  XP_002943404.2 
zebrafish
(Danio rerio)
Actinopterygii wufj98f092 wufj98f09 69.95(n)   334529  BC056802.1 
worm
(Caenorhabditis elegans)
Secernentea Y69E1A.73
aqp-21
Major intrinsic protein3
aqp-21
40(a)
(best of 2)3
49.45(n)1
38.91(a)1
  IV(10961471-10962477)3
1744671  NM_063571.41  NP_495972.11 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes --
Putative channel-like protein; similar to Fps1p; m...
13(a)
1 → many
VI(20847-22787) YFL054C


ENSEMBL Gene Tree for AQP10 (if available)
TreeFam Gene Tree for AQP10 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for AQP10 gene
AQP92  AQP32  AQP72  
5 SIMAP similar genes for AQP10 using alignment to 1 protein entry:     AQP10_HUMAN:
AQP9    AQP3    AQP7    AQP7P3    bA251O17.3

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1 Pseudogenes.org Pseudogene for AQP10
PGOHUM00000245010


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for AQP10 (see all 122)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1901679911,2
--154291595(+) CAGGCA/GTGAGC 1 -- us2k10--------
rs16856331,2
C,F,H--154291718(+) CATGGA/GTGATA 1 -- us2k119Minor allele frequency- G:0.13NS EA NA WA CSA 2344
rs761025931,2
F--154291852(+) CCCCAT/CAGGAG 1 -- us2k11Minor allele frequency- C:0.02EA 120
rs1486376561,2
--154291931(+) TGGTAA/TCAGCA 1 -- us2k10--------
rs359502071,2
C,F--154291958(+) TGTAGC/TGAATG 1 -- us2k110Minor allele frequency- T:0.27NA WA EA 550
rs1918339401,2
--154291978(+) GCTCCC/TAAGGG 1 -- us2k10--------
rs1421360341,2
--154292144(+) ATTTTA/GAAAAG 1 -- us2k10--------
rs66720101,2
C,F,A,H--154292161(+) ATTGTC/TTGTTT 1 -- us2k126Minor allele frequency- T:0.27NS EA NA WA 2924
rs16856341,2
C,F,A,H--154292192(+) TCTAGA/GAGGGC 1 -- us2k111Minor allele frequency- G:0.48NA WA CSA EA 260
rs16856351,2
C,F,A,H--154292320(+) AGAGTA/GGCATG 1 -- us2k110Minor allele frequency- G:0.10NA WA CSA 20

HapMap Linkage Disequilibrium report for AQP10 (154293566 - 154297801 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for AQP10:    About this table    
Variant IDTypeSubtypePubMed ID
nsv523934CNV Loss19592680
nsv521887CNV Gain19592680

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing AQP10
DNA2.0 Custom Variant and Variant Library Synthesis for AQP10

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 606578    OMIM disorders: --


Find genes that share disorders with AQP10           About GenesLikeMe

Genetic Association Database (GAD): AQP10
Human Genome Epidemiology (HuGE) Navigator: AQP10 (6 documents)

Export disorders for AQP10 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for AQP10 gene, integrated from 10 sources (see all 21):
(articles sorted by number of sources associating them with AQP10)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning of a new aquaporin (AQP10) abundantly expressed in duodenum and jejunum. (PubMed id 11573934)1, 2, 3, 9 Hatakeyama S.... Yamamoto T. (Biochem. Biophys. Res. Commun. 2001)
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
  3. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. ( a journal of cerebral circulation 2009)
  4. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1, 4 Chapuis J....Lambert J.C. (Mol. Psychiatry 2009)
  5. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin. (PubMed id 12084581)1, 2 Ishibashi K.... Imai M. (Biochim. Biophys. Acta 2002)
  8. Expression and localization of two isoforms of AQP10 in human small intestine. (PubMed id 15898950)1, 9 Li H....Yamamoto T. (Biol. Cell 2005)
  9. Compartmentalization of aquaporins in the human intestine. (PubMed id 18678926)1, 9 Cohly H.H....Rajnarayanan R.V. (Int J Environ Res Public Health 2008)
  10. Differential expression of intestinal membrane transporters in cholera patients. (PubMed id 17575980)1, 9 Flach C.F....LAPnnroth I. (FEBS Lett. 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 89872 HGNC: 16029 AceView: AQP10 Ensembl:ENSG00000143595 euGenes: HUgn89872
ECgene: AQP10 H-InvDB: AQP10

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for AQP10 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for AQP10 gene:
Search GeneIP for patents involving AQP10

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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