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Aliases for AQP10 Gene

Aliases for AQP10 Gene

  • Aquaporin 10 2 3
  • Small Intestine Aquaporin 3 4
  • Aquaglyceroporin-10 3 4
  • AQP-10 3 4
  • Aquaporin-10 3

External Ids for AQP10 Gene

Previous GeneCards Identifiers for AQP10 Gene

  • GC01P152110
  • GC01P150024
  • GC01P151068
  • GC01P151510
  • GC01P151106
  • GC01P152560
  • GC01P154294
  • GC01P125657

Summaries for AQP10 Gene

Entrez Gene Summary for AQP10 Gene

  • This gene encodes a member of the aquaglyceroporin family of integral membrane proteins. Members of this family function as water-permeable channels in the epithelia of organs that absorb and excrete water. This protein was shown to function as a water-selective channel, and could also permeate neutral solutes such as glycerol and urea. [provided by RefSeq, Jul 2008]

GeneCards Summary for AQP10 Gene

AQP10 (Aquaporin 10) is a Protein Coding gene. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity. An important paralog of this gene is AQP3.

UniProtKB/Swiss-Prot for AQP10 Gene

  • Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol.

Tocris Summary for AQP10 Gene

  • Aquaporins (AQPs)are integral membrane proteins that facilitate the transport of water across biological membranes along an osmotic gradient. There have been 13 AQP isoforms (AQP0-AQP12) identified in humans and rodents to date.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AQP10 Gene

Genomics for AQP10 Gene

Regulatory Elements for AQP10 Gene

Genomic Location for AQP10 Gene

154,321,090 bp from pter
154,325,325 bp from pter
4,236 bases
Plus strand

Genomic View for AQP10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AQP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AQP10 Gene

Proteins for AQP10 Gene

  • Protein details for AQP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q5VYD3
    • Q5VYD4
    • Q8NG70

    Protein attributes for AQP10 Gene

    301 amino acids
    Molecular mass:
    31763 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for AQP10 Gene


neXtProt entry for AQP10 Gene

Proteomics data for AQP10 Gene at MOPED

Post-translational modifications for AQP10 Gene

No Post-translational modifications

Other Protein References for AQP10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for AQP10 Gene

Domains for AQP10 Gene

Gene Families for AQP10 Gene

  • AQP :Ion channels / Aquaporins

Protein Domains for AQP10 Gene


Suggested Antigen Peptide Sequences for AQP10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96PS8
  • Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)
  • Belongs to the MIP/aquaporin (TC 1.A.8) family.
genes like me logo Genes that share domains with AQP10: view

Function for AQP10 Gene

Molecular function for AQP10 Gene

UniProtKB/Swiss-Prot Function:
Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol.

Gene Ontology (GO) - Molecular Function for AQP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0015204 urea transmembrane transporter activity IBA --
GO:0015250 water channel activity IBA --
GO:0015254 glycerol channel activity IBA --
genes like me logo Genes that share ontologies with AQP10: view

Animal Model Products

CRISPR Products

miRNA for AQP10 Gene

miRTarBase miRNAs that target AQP10

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AQP10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for AQP10 Gene

Localization for AQP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AQP10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for AQP10 Gene COMPARTMENTS Subcellular localization image for AQP10 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for AQP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with AQP10: view

Pathways for AQP10 Gene

genes like me logo Genes that share pathways with AQP10: view

Pathways by source for AQP10 Gene

Interacting Proteins for AQP10 Gene

Gene Ontology (GO) - Biological Process for AQP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006833 water transport TAS --
GO:0009636 response to toxic substance IDA 17575980
GO:0009992 cellular water homeostasis IBA --
GO:0015793 glycerol transport IBA --
genes like me logo Genes that share ontologies with AQP10: view

Compounds for AQP10 Gene

(1) HMDB Compounds for AQP10 Gene

Compound Synonyms Cas Number PubMed IDs
  • Dihydrogen oxide

(1) IUPHAR Ligand for AQP10 Gene

Ligand Type Action Affinity Pubmed IDs
Hg2+ Inhibitor None
genes like me logo Genes that share compounds with AQP10: view

Transcripts for AQP10 Gene

mRNA/cDNA for AQP10 Gene

(17) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AQP10 Gene

Aquaporin 10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AQP10

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AQP10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b

Relevant External Links for AQP10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AQP10 Gene

mRNA expression in normal human tissues for AQP10 Gene

mRNA differential expression in normal tissues according to GTEx for AQP10 Gene

This gene is overexpressed in Whole Blood (31.6) and Small Intestine - Terminal Ileum (4.2).

SOURCE GeneReport for Unigene cluster for AQP10 Gene Hs.259048

mRNA Expression by UniProt/SwissProt for AQP10 Gene

Tissue specificity: Expressed exclusively in duodenum and jejunum. Highest expression in absorptive epithelial cells at the tips of villi in the jejunum
genes like me logo Genes that share expressions with AQP10: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Expression partners for AQP10 Gene

Orthologs for AQP10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AQP10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia AQP10 35
  • 85.93 (n)
  • 78.12 (a)
AQP10 36
  • 78 (a)
(Canis familiaris)
Mammalia AQP10 35
  • 88.14 (n)
  • 86.58 (a)
(Pan troglodytes)
Mammalia AQP10 35
  • 99.78 (n)
  • 99.67 (a)
AQP10 36
  • 100 (a)
(Rattus norvegicus)
Mammalia LOC686596 35
  • 84.42 (n)
  • 86.92 (a)
(Monodelphis domestica)
Mammalia AQP10 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 46 (a)
(Gallus gallus)
Aves AQP10 35
  • 67.88 (n)
  • 65 (a)
AQP10 36
  • 60 (a)
(Anolis carolinensis)
Reptilia AQP10 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490571 35
  • 62.17 (n)
  • 61.94 (a)
(Danio rerio)
Actinopterygii wufj98f09 35
aqp10a 36
  • 44 (a)
aqp10b 36
  • 45 (a)
(Caenorhabditis elegans)
Secernentea M02F4.8 37
  • 35 (a)
Y69E1A.7 37
  • 40 (a)
aqp-2 35
  • 49.45 (n)
  • 38.91 (a)
aqp-1 36
  • 33 (a)
aqp-2 36
  • 37 (a)
aqp-3 36
  • 24 (a)
aqp-7 36
  • 33 (a)
aqp-8 36
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 13 (a)
Species with no ortholog for AQP10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AQP10 Gene

Gene Tree for AQP10 (if available)
Gene Tree for AQP10 (if available)

Paralogs for AQP10 Gene

Paralogs for AQP10 Gene

Selected SIMAP similar genes for AQP10 Gene using alignment to 1 proteins: Pseudogenes for AQP10 Gene

genes like me logo Genes that share paralogs with AQP10: view

Variants for AQP10 Gene

Sequence variations from dbSNP and Humsavar for AQP10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1194606 -- 154,321,784(+) CCCAT(C/T)TCTTT intron-variant
rs1194607 -- 154,322,180(-) CTGGG(A/G)CACTG intron-variant
rs1194608 -- 154,322,329(+) CCACC(C/T)GAAGT intron-variant
rs1194609 -- 154,322,602(+) CACGC(A/G)ATTCT intron-variant
rs1201589 -- 154,320,616(+) tggga(A/G)gctga upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for AQP10 Gene

Variant ID Type Subtype PubMed ID
nsv521887 CNV Gain 19592680
nsv523934 CNV Loss 19592680

Relevant External Links for AQP10 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AQP10 Gene

Disorders for AQP10 Gene

Relevant External Links for AQP10

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for AQP10 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for AQP10 Gene

Publications for AQP10 Gene

  1. Cloning of a new aquaporin (AQP10) abundantly expressed in duodenum and jejunum. (PMID: 11573934) Hatakeyama S. … Yamamoto T. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 23
  2. Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin. (PMID: 12084581) Ishibashi K. … Imai M. (Biochim. Biophys. Acta 2002) 3 4
  3. Expression and localization of two isoforms of AQP10 in human small intestine. (PMID: 15898950) Li H. … Yamamoto T. (Biol. Cell 2005) 3 23
  4. Differential expression of intestinal membrane transporters in cholera patients. (PMID: 17575980) Flach C.F. … LAPnnroth I. (FEBS Lett. 2007) 3 23
  5. Compartmentalization of aquaporins in the human intestine. (PMID: 18678926) Cohly H.H. … Rajnarayanan R.V. (Int J Environ Res Public Health 2008) 3 23

Products for AQP10 Gene

Sources for AQP10 Gene

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