Aliases for APPL2 Gene
Aliases for APPL2 Gene
- Adaptor Protein, Phosphotyrosine Interacting With PH Domain And Leucine Zipper 2 2 3 5
- Adaptor Protein, Phosphotyrosine Interaction, PH Domain And Leucine Zipper Containing 2 2 3
- Adapter Protein Containing PH Domain, PTB Domain And Leucine Zipper Motif 2 3 4
- DCC-Interacting Protein 13-Beta 2 3
- DIP13B 3 4
- DIP13 Beta 3
- Dip13-Beta 4
External Ids for APPL2 Gene
- HGNC: 18242
- Entrez Gene: 55198
- Ensembl: ENSG00000136044
- OMIM: 606231
- UniProtKB: Q8NEU8
Previous GeneCards Identifiers for APPL2 Gene
- GC12M104091
- GC12M105568
- GC12M102626
Summaries for APPL2 Gene
-
The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011]
GeneCards Summary for APPL2 Gene
APPL2 (Adaptor Protein, Phosphotyrosine Interacting With PH Domain And Leucine Zipper 2) is a Protein Coding gene. Diseases associated with APPL2 include Phelan-Mcdermid Syndrome. An important paralog of this gene is APPL1.
UniProtKB/Swiss-Prot for APPL2 Gene
-
Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APPL2 Gene
Genomics for APPL2 Gene
Regulatory Elements for APPL2 Gene
Enhancers for APPL2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH12G105225 | 1.9 | FANTOM5 Ensembl ENCODE dbSUPER | 21.3 | +4.9 | 4911 | 11.5 | PKNOX1 ARID4B SIN3A DMAP1 FEZF1 YY1 ZNF766 FOS SP3 MXD4 | WASHC4 APPL2 C12orf75 PIR46520 |
| GH12G105210 | 1.3 | Ensembl ENCODE dbSUPER | 25.6 | +22.1 | 22099 | 6.9 | SOX13 BMI1 RAD21 YY1 GATA3 ZNF366 POLR2A GATA2 ZNF157 RCOR1 | WASHC4 APPL2 C12orf75 PIR46520 |
| GH12G105091 | 1.3 | FANTOM5 Ensembl ENCODE | 24.1 | +143.9 | 143942 | 1.8 | CTCF PKNOX1 TAL1 CHD1 CHD7 RAD21 NR2F2 GATA2 POLR2A SCRT2 | WASHC4 APPL2 C12orf75 ALDH1L2 |
| GH12G105203 | 0.9 | ENCODE dbSUPER | 28.3 | +30.8 | 30751 | 3.1 | MAFG REST RAD21 ZNF316 MAFF NFE2 MAFK EMSY NFE2L2 | APPL2 WASHC4 C12orf75 GC12P105208 LOC105369953 |
| GH12G105218 | 1.2 | Ensembl ENCODE dbSUPER | 19.4 | +14.7 | 14682 | 6.5 | BCOR SCRT1 PKNOX1 NFIB ZSCAN4 ZNF10 HLF ZMYM3 ATF2 NFIC | WASHC4 APPL2 C12orf75 PIR46520 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around APPL2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the APPL2 gene promoter:
Regulatory Element Products
Genomic Location for APPL2 Gene
- Chromosome:
- 12
- Start:
- 105,173,296 bp from pter
- End:
- 105,236,238 bp from pter
- Size:
- 62,943 bases
- Orientation:
- Minus strand
Genomic View for APPL2 Gene
Genes around APPL2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q23.3 by Ensembl
- 12q23.3 by Entrez Gene
- 12q23.3 by HGNC
APPL2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for APPL2 Gene
Proteins for APPL2 Gene
-
Protein details for APPL2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NEU8-DP13B_HUMAN
- Recommended name:
- DCC-interacting protein 13-beta
- Protein Accession:
- Q8NEU8
- B7Z411
- B7Z4B0
- F5GZG0
- F8W1P5
- Q8N4R7
- Q9NVL2
Protein attributes for APPL2 Gene
- Size:
- 664 amino acids
- Molecular mass:
- 74493 Da
- Quaternary structure:
-
- Binds RAB5A/Rab5 through an N-terminal domain. This interaction is essential for its recruitment to endosomal membranes as well as its role in cell proliferation. Binds subunits of the NuRD/MeCP1 complex.
Protein Expression for APPL2 Gene
Post-translational modifications for APPL2 Gene
Other Protein References for APPL2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for APPL2
- Invitrogen Antibodies for APPL2
- antibodies-online Antibodies for APPL2: See all 42
- GeneTex APPL2 antibody for APPL2
-
Santa Cruz Biotechnology (SCBT) Antibodies for APPL2
Protein Products
-
OriGene Purified Proteins for APPL2
- Search Origene for MassSpec and Protein Over-expression Lysates for APPL2
- Origene Custom Protein Services for APPL2
- antibodies-online Proteins for APPL2: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for APPL2
Assay Products
No data available for DME Specific Peptides for APPL2 Gene
Domains & Families for APPL2 Gene
Gene Families for APPL2 Gene
Protein Domains for APPL2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for APPL2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for APPL2 Gene
Function for APPL2 Gene
Molecular function for APPL2 Gene
- UniProtKB/Swiss-Prot Function:
- Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 15016378 |
Phenotypes for APPL2 Gene
- MGI mutant phenotypes for APPL2:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for APPL2:
Animal Models for APPL2 Gene
- MGI Knock Outs for APPL2:
-
- Appl2 tm1.1Test
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for APPL2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for APPL2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for APPL2 gene
- Search ViGene Biosciences for APPL2
CRISPR Products
-
OriGene CRISPR knockouts for APPL2
-
Santa Cruz Biotechnology (SCBT) CRISPR for APPL2
- GenScript: Design CRISPR guide RNA sequences for APPL2
miRNA for APPL2 Gene
- miRTarBase miRNAs that target APPL2
miRNA Products
- Search ViGene Biosciences for APPL2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for APPL2
- Browse OriGene Inhibitory RNA Products For APPL2
-
ViGene Biosciences ready-to-package AAV shRNAs for APPL2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for APPL2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APPL2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for APPL2
-
ViGene Biosciences adenoviral particle packaged cDNA for APPL2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for APPL2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for APPL2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for APPL2 Gene
Localization for APPL2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for APPL2 Gene
- Early endosome membrane; Peripheral membrane protein. Nucleus. Note=Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| endosome | 5 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 15016378 |
| GO:0005737 | cytoplasm | IC | 15016378 |
| GO:0005768 | endosome | IEA | -- |
| GO:0010008 | endosome membrane | IDA | 15016378 |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for APPL2 Gene
No Data Available
Interacting Proteins for APPL2 Gene
Selected Interacting proteins:
Q8NEU8-DP13B_HUMAN
ENSP00000258530
for APPL2 Gene via
IID
STRING
UniProtKB
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007165 | signal transduction | TAS | 15016378 |
| GO:0008283 | cell proliferation | IDA | 15016378 |
No data available for Pathways by source and SIGNOR curated interactions for APPL2 Gene
Transcripts for APPL2 Gene
mRNA/cDNA for APPL2 Gene
- (11) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (187) Selected AceView cDNA sequences:
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for APPL2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for APPL2
-
Santa Cruz Biotechnology (SCBT) CRISPR for APPL2
- GenScript: Design CRISPR guide RNA sequences for APPL2
miRNA Products
- Search ViGene Biosciences for APPL2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for APPL2
- Browse OriGene Inhibitory RNA Products For APPL2
-
ViGene Biosciences ready-to-package AAV shRNAs for APPL2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for APPL2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APPL2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for APPL2 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (22.0), Heart (12.0), and Platelet (9.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for APPL2 Gene
NURSA nuclear receptor signaling pathways regulating expression of APPL2 Gene:
APPL2SOURCE GeneReport for Unigene cluster for APPL2 Gene:
Hs.506603mRNA Expression by UniProt/SwissProt for APPL2 Gene:
Q8NEU8-DP13B_HUMAN
Tissue specificity:
High levels in brain, heart, kidney and skeletal muscle.
Evidence on tissue expression from TISSUES for APPL2 Gene
- Intestine(4.3)
- Nervous system(2.3)
Primer Products
-
OriGene qPCR primer pairs for APPL2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for APPL2 Gene
Orthologs for APPL2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | APPL2 35 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | APPL2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | APPL2 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | APPL2 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | APPL2 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Appl2 35 16 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Appl2 34 |
|
||
| chicken (Gallus gallus) |
Aves | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| APPL2 34 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | APPL2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | appl2 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | appl2 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for APPL2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for APPL2 Gene
(1) SIMAP similar genes for APPL2 Gene using alignment to 7 proteins:
Variants for APPL2 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000063575 | -- | 105,232,252(+) | CTGCC(C/G)GACAC | intron-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs1000247758 | -- | 105,213,610(+) | TGACT(C/T)ATAAC | intron-variant | |
| rs1000327100 | -- | 105,203,337(+) | TATTA(C/T)AAATT | intron-variant | |
| rs1000370326 | -- | 105,201,929(+) | CCCCC(-/T)GGGGA | intron-variant | |
| rs1000405220 | -- | 105,174,628(+) | ATCTA(G/T)ACTGT | intron-variant |
Residual Variation Intolerance Score:
84.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.51;
77.64% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for APPL2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APPL2 Gene
Disorders for APPL2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| phelan-mcdermid syndrome |
|
|
Search APPL2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
DP13B_HUMAN- Note=A chromosomal aberration involving APPL2/DIP13B is found in patients with chromosome 22q13.3 deletion syndrome. Translocation t(12;22)(q24.1;q13.3) with SHANK3/PSAP2 (PubMed:11431708). {ECO:0000269 PubMed:11431708}.
Relevant External Links for APPL2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- APPL2
No data available for Genatlas for APPL2 Gene
Publications for APPL2 Gene
- Disruption of the ProSAP2 gene in a t(12;22)(q24.1;q13.3) is associated with the 22q13.3 deletion syndrome. (PMID: 11431708) Bonaglia M.C. … Zuffardi O. (Am. J. Hum. Genet. 2001) 2 3 4 22 64
- APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex. (PMID: 17030088) Nechamen C.A. … Dias J.A. (Mol. Cell. Endocrinol. 2007) 2 3 22 64
- Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription. (PMID: 19433865) Rashid S. … Miaczynska M. (J. Biol. Chem. 2009) 3 22 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
Products for APPL2 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for APPL2
- Search Origene for MassSpec and Protein Over-expression Lysates for APPL2
- Origene Custom Protein Services for APPL2
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for APPL2
- Browse OriGene Inhibitory RNA Products For APPL2
- OriGene qPCR primer pairs for APPL2
- OriGene CRISPR knockouts for APPL2
- OriGene ORF clones in human for APPL2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for APPL2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for APPL2
- GenScript Custom Assay Services for APPL2
- GenScript Custom overexpressing Cell Line Services for APPL2
- GenScript: Design CRISPR guide RNA sequences for APPL2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for APPL2
- Novus Biologicals proteins and lysates for APPL2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for APPL2: See all 42
- Search antibodies-online for kits
- antibodies-online Proteins for APPL2: See all 7
- Search antibodies-online for peptides
- GeneTex APPL2 antibody for APPL2
- Search GeneTex for Proteins for APPL2
- ViGene Biosciences adenoviral particle packaged cDNA for APPL2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for APPL2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for APPL2 gene
- Search ViGene Biosciences for APPL2
- Santa Cruz Biotechnology (SCBT) Antibodies for APPL2
- Search Santa Cruz Biotechnology (SCBT) for APPL2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for APPL2
- Horizon Cell Lines for APPL2
- Cyagen custom Knockout/knockin (KOKI) mouse models for APPL2
- VectorBuilder custom plasmid, inducible vectors for APPL2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APPL2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for APPL2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer