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APPL2 Gene

protein-coding   GIFtS: 54
GCID: GC12M105568

Adaptor Protein, Phosphotyrosine Interaction, PH Domain...

  See APPL2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adaptor Protein, Phosphotyrosine Interaction, PH Domain And Leucine
Zipper Containing 21 2
     DIP13 Beta2
Adapter Protein Containing PH Domain, PTB Domain And Leucine Zipper Motif
22 3
     Dip13-beta3
DIP13B2 3     FLJ106595
DCC-Interacting Protein 13-Beta2     

External Ids:    HGNC: 182421   Entrez Gene: 551982   Ensembl: ENSG000001360447   OMIM: 6062315   UniProtKB: Q8NEU83   

Export aliases for APPL2 gene to outside databases

Previous GC identifers: GC12M104091 GC12M102626


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for APPL2 Gene:
The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a
signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central
pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5
through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in
response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase
/methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal
aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome,
also known as Phelan-McDermid syndrome. (provided by RefSeq, Oct 2011)

GeneCards Summary for APPL2 Gene:
APPL2 (adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2) is a protein-coding gene. Diseases associated with APPL2 include phelan-mcdermid syndrome. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is APPL1.

UniProtKB/Swiss-Prot: DP13B_HUMAN, Q8NEU8
Function: Required for the regulation of cell proliferation in response to extracellular signals mediated by an
early endosomal compartment. Links Rab5 to nuclear signal transduction

Gene Wiki entry for APPL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the APPL2 gene promoter:
         Elk-1   Pax-5   p300   AP-4   RelA   NF-kappaB   AREB6   NRF-2   COMP1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAPPL2 promoter sequence
   Search Chromatin IP Primers for APPL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat APPL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.1   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q24.1

APPL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APPL2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M105568:  view genomic region     (about GC identifiers)

Start:
105,567,074 bp from pter      End:
105,630,016 bp from pter
Size:
62,943 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DP13B_HUMAN, Q8NEU8 (See protein sequence)
Recommended Name: DCC-interacting protein 13-beta  
Size: 664 amino acids; 74493 Da
Subunit: Binds RAB5A/Rab5 through an N-terminal domain. This interaction is essential for its recruitment to
endosomal membranes as well as its role in cell proliferation. Binds subunits of the NuRD/MeCP1 complex
1 PDB 3D structure from and Proteopedia for APPL2:
4H8S (3D)    
Secondary accessions: B7Z411 B7Z4B0 F5GZG0 F8W1P5 Q8N4R7 Q9NVL2
Alternative splicing: 3 isoforms:  Q8NEU8-1   Q8NEU8-2   Q8NEU8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for APPL2: NX_Q8NEU8

Explore proteomics data for APPL2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See APPL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001238833.1  NP_001238834.1  NP_060641.2  

    ENSEMBL proteins: 
     ENSP00000258530   ENSP00000449410   ENSP00000444472   ENSP00000447828   ENSP00000446917  
     ENSP00000446510   ENSP00000448569   ENSP00000449767   ENSP00000447520  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    3 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR006020 PTB/PI_dom

    Graphical View of Domain Structure for InterPro Entry Q8NEU8

    ProtoNet protein and cluster: Q8NEU8

    2 Blocks protein domains:
    IPB001849 Pleckstrin-like
    IPB006020 Phosphotyrosine interaction domain


    UniProtKB/Swiss-Prot: DP13B_HUMAN, Q8NEU8
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 PID domain


    Find genes that share domains with APPL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DP13B_HUMAN, Q8NEU8
    Function: Required for the regulation of cell proliferation in response to extracellular signals mediated by an
    early endosomal compartment. Links Rab5 to nuclear signal transduction

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15016378
         
    Find genes that share ontologies with APPL2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for APPL2:
     Decreased viability of wild-ty 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for APPL2
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    miRNA
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    miRTarBase miRNAs that target APPL2:
    hsa-mir-124-3p (MIRT022951), hsa-mir-375 (MIRT019898)

    Block miRNA regulation of human, mouse, rat APPL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate APPL2 (see all 25):
    hsa-miR-320a hsa-miR-137 hsa-miR-520d-5p hsa-miR-219-5p hsa-miR-340 hsa-miR-133a hsa-miR-149 hsa-miR-558
    SwitchGear 3'UTR luciferase reporter plasmidAPPL2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DP13B_HUMAN, Q8NEU8: Early endosome membrane; Peripheral membrane protein. Nucleus. Note=Early endosomal
    membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following
    internalization of EGF
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    nucleus5
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15016378
    GO:0005737cytoplasm IC15016378
    GO:0010008endosome membrane IDA15016378
    GO:0016581colocalizes with NuRD complex IDA15016378
    GO:0031901early endosome membrane IEA--

    Find genes that share ontologies with APPL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for APPL2 About    
    See pathways by source

    SuperPathContained pathways About
    1EGFR1 Signaling Pathway
    EGFR1 Signaling Pathway


    1 BioSystems Pathway for APPL2
        EGFR1 Signaling Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for APPL2
    Interactions:

        Search GeneGlobe Interaction Network for APPL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for APPL2 (Q8NEU82, 3 ENSP000002585304) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPL1Q9UKG12, 3, ENSP000002882664MINT-66149 I2D: score=6 STRING: ENSP00000288266
    RAB22AQ9UL262, 3, ENSP000002440404MINT-67006 I2D: score=5 STRING: ENSP00000244040
    MTA2O947763, ENSP000002788234I2D: score=3 STRING: ENSP00000278823
    RUVBL2Q9Y2303, ENSP000002214134I2D: score=1 STRING: ENSP00000221413
    RAB5AP203393, ENSP000002730474I2D: score=2 STRING: ENSP00000273047
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007049cell cycle IEA--
    GO:0007165signal transduction TAS15016378
    GO:0008283cell proliferation IDA15016378

    Find genes that share ontologies with APPL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for APPL2 (DP13B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for APPL2 gene (3 alternative transcripts): 
    NM_001251904.1  NM_001251905.1  NM_018171.3  

    Unigene Cluster for APPL2:

    Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
    Hs.506603  [show with all ESTs]
    Unigene Representative Sequence: BX649010
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258530(uc010swt.2 uc010swu.1 uc001tlf.1 uc001tlg.1)
    ENST00000547439 ENST00000539978(uc009zuq.3) ENST00000547790 ENST00000546731
    ENST00000551662 ENST00000553109 ENST00000548425 ENST00000547809 ENST00000552945
    ENST00000549573 ENST00000549974 ENST00000550648 ENST00000546768 ENST00000553097
    ENST00000549056
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate APPL2 (see all 25):
    hsa-miR-320a hsa-miR-137 hsa-miR-520d-5p hsa-miR-219-5p hsa-miR-340 hsa-miR-133a hsa-miR-149 hsa-miR-558
    SwitchGear 3'UTR luciferase reporter plasmidAPPL2 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat APPL2

    Additional mRNA sequence: 

    AK001521.2 AK290562.1 AK293783.1 AK296610.1 AK297100.1 AK310377.1 AY113704.1 BC028008.1 
    BC033731.1 BX649010.1 

    12 DOTS entries:

    DT.317130  DT.100643630  DT.414912  DT.100785938  DT.86837665  DT.121114340  DT.121114357  DT.95373084 
    DT.100785937  DT.426748  DT.92451418  DT.99967045 

    Selected AceView cDNA sequences (see all 187):

    AL533329 AW848791 CB144094 AI275114 BX503864 CD245274 BM712089 BQ771962 
    N59312 BG036336 AI654146 W72093 AI972901 CB963450 BQ216388 W45083 
    BQ014075 AI351566 AW794409 CB131993 AI694860 CA446013 AK001521 BM995399 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    APPL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCTTGGTA
    APPL2 Expression
    About this image


    APPL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    APPL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    APPL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.506603

    UniProtKB/Swiss-Prot: DP13B_HUMAN, Q8NEU8
    Tissue specificity: High levels in brain, heart, kidney and skeletal muscle

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for APPL2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Appl21 , 5 adaptor protein, phosphotyrosine interaction, PH domain more1, 5 87.92(n)1
    92.75(a)1
      10 (41.29 cM)5
    2161901  NM_145220.21  NP_660255.11 
     836000335 
    chicken
    (Gallus gallus)
    Aves APPL21 adaptor protein, phosphotyrosine interaction, PH domain more 77.25(n)
    84.35(a)
      418075  XM_416311.4  XP_416311.2 
    lizard
    (Anolis carolinensis)
    Reptilia APPL26
    adaptor protein, phosphotyrosine interaction, PH d...
    82(a)
    1 ↔ 1
    5(18798814-18831826)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia appl21 adaptor protein, phosphotyrosine interaction, PH domain more 72.21(n)
    76.31(a)
      100127202  NM_001112918.1  NP_001106389.1 
    zebrafish
    (Danio rerio)
    Actinopterygii appl21 adaptor protein, phosphotyrosine interaction, PH domain more 66.72(n)
    70.84(a)
      100000135  NM_001128075.1  NP_001121547.1 


    ENSEMBL Gene Tree for APPL2 (if available)
    TreeFam Gene Tree for APPL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for APPL2 gene
    APPL12  
    1 SIMAP similar gene for APPL2 using alignment to 7 protein entries:     DP13B_HUMAN (see all proteins):
    APPL1

    Find genes that share paralogs with APPL2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for APPL2 (see all 1586)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2021735191,2
    C--102639766(+) TAAAT-/ATATATATC
    ATATATATATC
    ATATA
    3 -- int10--------
    rs1455988081,2
    C--102639777(+) ATCAT-/ATA   
      TATATC
    ATATA
    3 -- int10--------
    rs3759881401,2
    C--102639780(+) TATAT-/ATG   
      ATATCG
    ATATC
    6 -- int1 cds10--------
    rs1459766971,2
    C--102639880(+) ATATC-/ATAT/A
    TATCATAT
    ATATC
    6 -- int1 cds10--------
    rs361041301,2
    C--102647969(+) TAGTTAA/-AAAAA 3 -- int11Minor allele frequency- -:0.00CSA 2
    rs114648901,2
    C--102663948(+) TCCAAG/-ACCCC 3 -- int11Minor allele frequency- -:0.00CSA 2
    rs562910251,2
    C--102663949(+) TCCAAA/C/GCCCCG 3 -- int12NA CSA 3
    rs678968881,2
    C--102663949(-) CGGGGGC/TTTGGA 3 -- int11Minor allele frequency- T:0.50NA 2
    rs357136911,2
    C--102663950(+) ACCCC-/C/GGCTTT 3 -- int10--------
    rs58006571,2
    C--102665268(+) atctc-/AA/AAA
            
    aaaaa
    6 -- int1 cds1 trp30--------

    HapMap Linkage Disequilibrium report for APPL2 (105567074 - 105630016 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for APPL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899499CNV Loss21882294
    nsv832506CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing APPL2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606231    OMIM disorders: --

    UniProtKB/Swiss-Prot: DP13B_HUMAN, Q8NEU8
  • Note=A chromosomal aberration involving APPL2/DIP13B is found in patients with chromosome 22q13.3
    deletion syndrome. Translocation t(12;22)(q24.1;q13.3) with SHANK3/PSAP2

  • 1 disease for APPL2:    
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    phelan-mcdermid syndrome


    Find genes that share disorders with APPL2           About GenesLikeMe


    Export disorders for APPL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for APPL2 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with APPL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Disruption of the ProSAP2 gene in a t(12;22)(q24.1;q13.3) is associated with the 22q13.3 deletion syndrome. (PubMed id 11431708)1, 2, 3, 9 Bonaglia M.C.... Zuffardi O. (Am. J. Hum. Genet. 2001)
    2. APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex. (PubMed id 17030088)1, 3, 9 Nechamen C.A....Dias J.A. (Mol. Cell. Endocrinol. 2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment. (PubMed id 15016378)1, 2 Miaczynska M.... Zerial M. (Cell 2004)
    6. Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription. (PubMed id 19433865)1, 9 Rashid S....Miaczynska M. (J. Biol. Chem. 2009)
    7. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    8. Multifunctional protein APPL2 contributes to survival of human glioma cells. (PubMed id 22989406)1 Pyrzynska B....Miaczynska M. (Mol Oncol 2013)
    9. Genetic variations in APPL2 are associated with overweight and obesity in a Chinese population with normal glucose tolerance. (PubMed id 22462604)1 Jiang S....Jia W. (BMC Med. Genet. 2012)
    10. Membrane curvature protein exhibits interdomain flexibility and binds a small GTPase. (PubMed id 23055524)1 King G.J....Martin J.L. (J. Biol. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55198 HGNC: 18242 AceView: DIP13B Ensembl:ENSG00000136044 euGenes: HUgn55198
    ECgene: APPL2 H-InvDB: APPL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for APPL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for APPL2 gene:
    Search GeneIP for patents involving APPL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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