Aliases for APPL1 Gene
- Adaptor Protein, Phosphotyrosine Interacting With PH Domain And Leucine Zipper 1 2 3
- Adaptor Protein, Phosphotyrosine Interaction, PH Domain And Leucine Zipper Containing 1 2 3 5
- Adapter Protein Containing PH Domain, PTB Domain And Leucine Zipper Motif 1 3 4
- Dip13-Alpha 3 4
- APPL 3 4
- Adaptor Protein Containing PH Domain, PTB Domain And Leucine Zipper Motif 1 3
- Signaling Adaptor Protein DIP13alpha 3
External Ids for APPL1 Gene
Previous GeneCards Identifiers for APPL1 Gene
The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008]
GeneCards Summary for APPL1 Gene
APPL1 (Adaptor Protein, Phosphotyrosine Interacting With PH Domain And Leucine Zipper 1) is a Protein Coding gene. Diseases associated with APPL1 include Maturity-Onset Diabetes Of The Young, Type 14 and Myopathy Of Extraocular Muscle. Among its related pathways are A-beta Pathways: Uptake and Degradation and Pathways in cancer. GO annotations related to this gene include identical protein binding and protein kinase B binding. An important paralog of this gene is APPL2.
UniProtKB/Swiss-Prot for APPL1 Gene
Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.