APPL1 Gene
protein-coding GIFtS: 59
GCID: GC03P057237
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|
adaptor protein, phosphotyrosine interaction, PH domain...
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Aliases
for APPL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Adaptor Protein, Phosphotyrosine Interaction, PH Domain And Leucine ZipperContaining 11 2 | | DCC-Interacting Protein 13-Alpha2 | | APPL1 2 3 5 | | Dip13-Alpha1 | | Adapter Protein Containing PH Domain, PTB Domain And Leucine Zipper Motif 12 3 | | Signaling Adaptor Protein DIP13alpha2 | | DIP13alpha2 | | DIP13A3 | | Adaptor Protein Containing PH Domain, PTB Domain And Leucine Zipper Motif 12 | | Dip13-Alpha1 | | AKT2 Interactor2 | | KIAA14283 |
Export aliases for APPL1 gene to outside databasesPrevious GC identifer: GC09U990006 |
Summaries
for APPL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for APPL1:
The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in thecrosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many otherproteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. Thisprotein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: DP13A_HUMAN, Q9UKG1Function: Required for the regulation of cell proliferation in response to extracellular signals from an earlyendosomal compartment. Links Rab5 to nuclear signal transduction
Gene Wiki entry for APPL1
|
Genomic Views
for APPL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the APPL1 gene promoter:
AP-1 ATF-2 FOXO1a CUTL1 c-Jun FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for APPL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APPL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.1-p14.3 Ensembl cytogenetic band: 3p14.3 HGNC cytogenetic band: 3p21.1-p14.3APPL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P057237: view genomic region
(about GC identifiers)
Start:
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57,261,765 bp from pter |
End:
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57,312,980 bp from pter |
Size:
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51,216 bases |
Orientation:
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plus strand |
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Proteins
for APPL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DP13A_HUMAN, Q9UKG1 (See
protein sequence)Recommended Name: DCC-interacting protein 13-alpha Size: 709 amino acids; 79663 Da
Subunit: Binds RAB5A/Rab5 through an N-terminal domain. This interaction is essential for its recruitment to endosomalmembranes as well as its role in cell proliferation. Binds DCC and the catalytic domain of the inactive form of AKT2through its PID domain. Binds PIK3CA and subunits of the NuRD/MeCP1 complex. Interacts with OCRL and INPP5B
Subcellular location: Early endosome membrane; Peripheral membrane protein. Nucleus. Note=Early endosomalmembrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes followinginternalization of EGF
6/7 PDB 3D structures from  and Proteopedia  for APPL1 (see all 7):2EJ8 (3D)
2ELA (3D)
2ELB (3D)
2Q12 (3D)
2Q13 (3D)
2Z0N (3D)
Secondary accessions: Q9P2B9Explore the universe of human proteins at neXtProt for APPL1: NX_Q9UKG1
Post-translational modifications:
Phosophorylation at Ser-410 by PKA severely impairs binding to OCRL1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UKG1
APPL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036228.1
ENSEMBL proteins: ENSP00000288266 ENSP00000419644 ENSP00000406095 ENSP00000441429 Reactome Protein details: Q9UKG1
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
APPL1 for ontologies About GeneDecksing
APPL1 Antibody Products:
Assay Products for APPL1: |
Protein
Domains /
Families
for APPL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
APPL1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UKG1ProtoNet protein and cluster: Q9UKG1 2 Blocks protein families: IPB001849 Pleckstrin-like IPB006020 Phosphotyrosine interaction domain
UniProtKB/Swiss-Prot: DP13A_HUMAN, Q9UKG1Domain: Overexpression of an N-terminal domain (residues 1-319) or a C-terminal region (residues 273-709) has aproapoptotic effectDomain: The F&H motif, an approximately 12-13 amino-acid sequence centered around Phe and His residues, is essentialfor binding to OCRL and INPP5B (PubMed:21666675)Similarity: Contains 1 PH domainSimilarity: Contains 1 PID domain |
Function
for APPL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DP13A_HUMAN, Q9UKG1Function: Required for the regulation of cell proliferation in response to extracellular signals from an earlyendosomal compartment. Links Rab5 to nuclear signal transduction Genatlas biochemistry entry for APPL1:amyloid beta (A4) precursor protein-like 1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APPL1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APPL1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for APPL1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APPL1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APPL1 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
APPL1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for APPL1:
Animal Models:
Mouse knock-outs for APPL1: Appl1tm1Ymli Appl1tm1.2Test
7 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Appl1):
APPL1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for APPL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ubiquitinated Orc1 is degraded by the proteasome | | | 2 | Cytoskeletal Signaling | | | 3 | Role of DCC in regulating apoptosis | | | 4 | FSH signaling pathway | | | 5 | EGFR1 Signaling Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  R&D Systems Pathway for APPL1
1 
Cell Signaling Technology (CST) Pathway for APPL1
3  BioSystems Pathways for APPL1
3 
Reactome Pathways for APPL1
2 
Kegg Pathways (Kegg details for APPL1):
APPL1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for APPL1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/44 Interacting proteins for APPL1 (Q9UKG11, 2, 3 ENSP000002882664) via UniProtKB, MINT, STRING, and/or I2D (see all 44)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| RAB5A | P203392, 3, ENSP000002730474 | MINT-5208195 MINT-5207947 MINT-5208011 MINT-5208211 MINT-5208131 MINT-5208179 MINT-5207810 MINT-5208163 MINT-5208092 MINT-5204180 MINT-5207850 MINT-5207979 MINT-5208147 MINT-5208115 MINT-5207882 MINT-5204043 MINT-5207931 I2D:
score=3 STRING: ENSP00000273047 | | RAB21 | Q9UL252, 3, ENSP000002612634 | MINT-5207865 MINT-5207834 MINT-5207897 MINT-5208028 MINT-5207964 MINT-5208076 MINT-5207996 MINT-5207916 MINT-5204063 MINT-5208044 MINT-5208060 I2D:
score=1 STRING: ENSP00000261263 | | RAB22A | Q9UL262, 3, ENSP000002440404 | MINT-5204082 I2D:
score=1 STRING: ENSP00000244040 | | ADIPOR2 | Q86V241, 3 | EBI-741243,EBI-1769445 I2D:
score=1 | | EGFR | P005332, 3, ENSP000002754934 | MINT-74479 MINT-74478 I2D:
score=2 STRING: ENSP00000275493 |
About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
APPL1 for ontologies About GeneDecksing
|
Drugs & Compounds
for APPL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
APPL1 for compounds About GeneDecksing
 Browse Tocris compounds for APPL1
4 Novoseek chemical compound relationships for APPL1 gene About this table
Search CenterWatch for drugs/clinical trials and news about APPL1 / DP13A
|
Transcripts
for APPL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for APPL1 gene: NM_012096.2 Unigene Cluster for APPL1: Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 Hs.476415 [show with all ESTs]Unigene Representative Sequence: NM_0120969 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000288266(uc011bey.1 uc003dio.3) ENST00000482800(uc010hnb.3)
ENST00000495803 ENST00000468342 ENST00000444459 ENST00000464446 ENST00000488530
ENST00000492501 ENST00000542404
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APPL1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APPL1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: APPL1 (NM_012096) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for APPL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APPL1 |
Additional cDNA sequence: AB037849.2 AF169797.1 AF424738.1 AK299008.1 AK310716.1 BC010911.1 BC028599.2 12 DOTS entries: DT.446507 DT.95173832 DT.120849391 DT.102831436 DT.120849366 DT.120849405 DT.91745628 DT.91941675 DT.100846330 DT.121185668 DT.40127103 DT.97803138 24/216 AceView cDNA sequences (see all 216): BM904076 AF169797 BU627922 BU173323 AI458803 BI859779 AA916880 AA749042 BU618897 CD172436 BI857805 CB150766 AI337416 F08741 AA322134 AL547523 BE302345 AA312647 BP337120 BE889588 AW471417 F04978 CD678158 AA243013
GeneLoc Exon Structure
|
Expression
for APPL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| APPL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See APPL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for APPL1
SOURCE GeneReport for Unigene cluster: Hs.476415
UniProtKB/Swiss-Prot: DP13A_HUMAN, Q9UKG1Tissue specificity: High levels in heart, ovary, pancreas and skeletal muscle
SABiosciences Custom PCR Arrays for APPL1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for APPL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat APPL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APPL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APPL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APPL1 |
Orthologs
for APPL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for APPL1 gene from 4/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
APPL11 |
adaptor protein, phosphotyrosine interaction, PH domain more |
81.92(n)
91.36(a) |
|
416002 XM_414344.3 XP_414344.3 |
lizard
(Anolis carolinensis) |
Reptilia |
APPL16 |
-- |
89(a) |
1 ↔ 1 |
2(163043309-163071146) |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC689862 |
hypothetical protein MGC68986 |
77.92(n) |
|
BC060752.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
appl11 |
adaptor protein, phosphotyrosine interaction, PH domain more |
71.95(n)
80.59(a) |
|
571540 NM_001128074.1 NP_001121546.1 |
ENSEMBL Gene Tree for APPL1 (if available)
TreeFam Gene Tree for APPL1 (if available) |
Paralogs
for APPL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for APPL1 gene
- APPL22
1 SIMAP similar gene for APPL1 using alignment to 4 protein entries: DP13A_HUMAN (see all proteins):APPL2
APPL1 for paralogs About GeneDecksing
|
Genomic Variants
for APPL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for APPL1 (57261765 - 57312980 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for APPL1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing APPL1 |
|
Disorders
/ Diseases
for APPL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
APPL1 for disorders About GeneDecksing
OMIM gene information: 604299
OMIM disorders: --
17  diseases for APPL1: About MalaCardsprader-willi syndrome type 2 diabetes mellitus skin lipoma nephronopthisis
exophthalmos intellectual disability diabetes mellitus muscular atrophy
angelman syndrome microcephaly neurodegeneration ovarian cancer
colorectal cancer obesity cerebritis cholesterol
neuronitis
5 diseases from the University of Copenhagen DISEASES database for APPL1:Nephronophthisis Prader-Willi syndrome Angelman syndrome Intellectual disability
Exophthalmos 1 Novoseek disease relationship for APPL1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| alzheimers disease |
31.5 |
1 |
12456644 (1) |
Human Genome Epidemiology (HuGE) Navigator: APPL1 (2 documents)
Export disorders for APPL1 gene to outside databases
|
Publications
for APPL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for APPL1 gene, integrated from 9 sources (see all 78):
(articles sorted by number of sources associating them with APPL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. (PubMed id 10490823)1, 2, 3, 9 Mitsuuchi Y....Testa J.R. (1999)
- APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex. (PubMed id 17030088)1, 3, 9 Nechamen C.A....Dias J.A. (2007)
- APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment. (PubMed id 15016378)1, 2, 9 Miaczynska M.... Zerial M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Mediation of the DCC apoptotic signal by DIP13 alpha. (PubMed id 12011067)1, 2 Liu J....Chen Y.Q. (2002)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
- APPL suppresses androgen receptor transactivation via potentiating Akt activity. (PubMed id 12621049)1, 9 Yang L....Chang C. (2003)
- Functional characterization of the interactions betwe en endosomal adaptor protein APPL1 and the NuRD co-repressor complex. (PubMed id 19686092)1, 9 Banach-Orlowska M....Miaczynska M. (2009)
- APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. (PubMed id 16622416)1, 9 Mao X....Dong L.Q. (2006)
|
External Searches for APPL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing APPL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing APPL1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing APPL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for APPL1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for APPL1 gene:
Search GeneIP for patents involving APPL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for APPL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
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| | |  | OriGene Antibodies for APPL1 | | OriGene shRNA RFP for APPL1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APPL1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for APPL1 | | | OriGene Protein Over-expression Lysate for APPL1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for APPL1 | | OriGene 3'-UTR Clone for APPL1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APPL1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APPL1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for APPL1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for APPL1 | | OriGene Custom Protein Services for APPL1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat APPL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing APPL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APPL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APPL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APPL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APPL1 |
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| | Antibodies & Assays for APPL1 (APPL) |
| | | | Search Tocris compounds for APPL1 |
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 | | | APPL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APPL1 |
|  |  |  | | | | ThermoFisher Antibody for APPL1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APPL1 |
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