APPBP2 Gene
protein-coding GIFtS: 54
GCID: GC17M058520
|
|
amyloid beta precursor protein (cytoplasmic tail) binding...(Previous name: amyloid beta precursor protein (cytoplasmic tail)-binding...)
| |
Aliases
for APPBP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Amyloid Beta Precursor Protein (Cytoplasmic Tail) Binding Protein 21 2 | | APP-BP22 3 | | PAT11 2 3 5 | | Amyloid Beta Precursor Protein (Cytoplasmic Tail)-Binding Protein 21 | | KIAA02281 3 | | HS.840842 | | Amyloid Beta Precursor Protein-Binding Protein 22 3 | | Amyloid Protein-Binding Protein 22 | | Protein Interacting With APP Tail 12 3 | | |
Export aliases for APPBP2 gene to outside databasesPrevious GC identifers: GC17M058257 GC17M060971 GC17M058862 GC17M058994 GC17M055875 GC17M053891 |
Summaries
for APPBP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for APPBP2:
The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursorprotein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein withsignal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. This genehas been found to be highly expressed in breast cancer. Multiple polyadenylation sites have been found for this gene.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: APBP2_HUMAN, Q92624Function: May play a role in intracellular protein transport. May be involved in the translocation of APP alongmicrotubules toward the cell surface
Gene Wiki entry for APPBP2
|
Genomic Views
for APPBP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the APPBP2 gene promoter:
HTF CUTL1 GATA-1 RORalpha2 POU2F1 POU2F1a SEF-1 (1) MRF-2 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for APPBP2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APPBP2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q23.2 Ensembl cytogenetic band: 17q23.2 HGNC cytogenetic band: 17q23.2APPBP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M058520: view genomic region
(about GC identifiers)
Start:
|
58,520,520 bp from pter |
End:
|
58,603,580 bp from pter |
Size:
|
83,061 bases |
Orientation:
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minus strand |
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Proteins
for APPBP2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: APBP2_HUMAN, Q92624 (See
protein sequence)Recommended Name: Amyloid protein-binding protein 2 Size: 585 amino acids; 66853 Da
Subunit: Binds APP
Subcellular location: Nucleus. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein (Potential).Note=Associated with membranes and microtubules
Sequence caution: Sequence=BAA13217.1; Type=Erroneous initiation;
Secondary accessions: A8K862 O95095 Q8WVC9Explore the universe of human proteins at neXtProt for APPBP2: NX_Q92624
Post-translational modifications:
Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92624
APPBP2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006371.2
ENSEMBL proteins: ENSP00000083182 ENSP00000467025 ENSP00000466802 ENSP00000464962
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
APPBP2 for ontologies About GeneDecksing
APPBP2 Antibody Products:
Assay Products for APPBP2: |
Protein
Domains /
Families
for APPBP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
APPBP2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q92624ProtoNet protein and cluster: Q92624 UniProtKB/Swiss-Prot: APBP2_HUMAN, Q92624Similarity: Contains 8 TPR repeats |
Function
for APPBP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: APBP2_HUMAN, Q92624Function: May play a role in intracellular protein transport. May be involved in the translocation of APP alongmicrotubules toward the cell surface Genatlas biochemistry entry for APPBP2:amyloid beta precursor protein binding protein 2, cytoplasmic,also associating with membranes cofractionating with APPvesicle,interacting with microtubule,binding the basolateral sorting signal in the cytoplasmic tail of APP
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APPBP2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APPBP2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
APPBP2 for ontologies About GeneDecksing
|
Pathways & Interactions
for APPBP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Regulation of Androgen receptor activity | |
1  BioSystems Pathway for APPBP2
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for APPBP2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/77 Interacting proteins for APPBP2 (Q926241, 2, 3 ENSP000000831824) via UniProtKB, MINT, STRING, and/or I2D (see all 77)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
APPBP2 for ontologies About GeneDecksing
|
Drugs & Compounds
for APPBP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for APPBP2
Search CenterWatch for drugs/clinical trials and news about APPBP2 / APBP2
|
Transcripts
for APPBP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for APPBP2 gene: NM_006380.2 Unigene Cluster for APPBP2: Amyloid beta precursor protein (cytoplasmic tail) binding protein 2 Hs.84084 [show with all ESTs]Unigene Representative Sequence: NM_0063806 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000083182(uc002iys.1 uc010ddl.1) ENST00000589341 ENST00000592995
ENST00000590244 ENST00000588668 ENST00000585368
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APPBP2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APPBP2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: APPBP2 (NM_006380) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for APPBP2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APPBP2 |
Additional cDNA sequence: AF017782.1 AK292227.1 AK307666.1 BC018121.1 D86981.1 9 DOTS entries: DT.453197 DT.95307307 DT.95183631 DT.75184561 DT.120980652 DT.95307305 DT.95307306 DT.120980653 DT.91908113 24/231 AceView cDNA sequences (see all 231): BQ018406 AL046686 AI889958 BM679055 BQ921742 NM_006380 AL596945 BM469502 AL079557 BM549226 AU140096 BM829186 BM823614 AA811911 BQ066886 BC018121 BM769359 AA046877 BM722548 AL157428 AL079558 AW070505 CD723163 BU621440
GeneLoc Exon Structure
|
Expression
for APPBP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| APPBP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See APPBP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for APPBP2
SOURCE GeneReport for Unigene cluster: Hs.84084
SABiosciences Custom PCR Arrays for APPBP2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for APPBP2
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APPBP2 |
Orthologs
for APPBP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for APPBP2 gene from 6/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Appbp21 , 5 |
amyloid beta precursor protein (cytoplasmic tail) binding more1, 5 |
91.28(n)1
99.15(a)1 |
|
11 (51.34 cM)5
668841 NM_025825.31 NP_080101.11
851872625 |
chicken
(Gallus gallus) |
Aves |
APPBP21 |
amyloid beta precursor protein (cytoplasmic tail) binding more |
84.65(n)
96.4(a) |
|
417645 NM_001030723.1 NP_001025894.1 |
lizard
(Anolis carolinensis) |
Reptilia |
APPBP26 |
-- |
96(a) |
1 ↔ 1 |
GL343393.1(486220-500276) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.237962 |
Xenopus laevis transcribed sequence with moderate similarity more |
80.85(n) |
|
BG485979.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb78e112 |
Transcribed sequence with moderate similarity to protein more |
77(n) |
|
57047764 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG106953
Pat11 |
microtubule-based movement kinesin motor3
Protein interacting with APP tail-11 |
47(a)3
51.05(n)1
47.93(a)1 |
|
6C13
315931 NM_132100.31 NP_572328.11 |
ENSEMBL Gene Tree for APPBP2 (if available)
TreeFam Gene Tree for APPBP2 (if available) |
Paralogs
for APPBP2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for APPBP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for APPBP2 (58520520 - 58603580 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for APPBP2
3 CNVs: 88574 77691 67237 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing APPBP2 |
|
Disorders
/ Diseases
for APPBP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
APPBP2 for disorders About GeneDecksing
OMIM gene information: 605324
OMIM disorders: --
3  diseases for APPBP2: About MalaCardsbreast cancer alzheimer's disease herpes simplex
Export disorders for APPBP2 gene to outside databases
|
Publications
for APPBP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for APPBP2 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with APPBP2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein. (PubMed id 9843960)1, 2, 3, 9 Zheng P.... Pimplikar S.W. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus. (PubMed id 11742091)1, 2 Gao Y. and Pimplikar S.W. (2001)
- Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T....Nomura N. (1996)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- The multi-copy mouse gene Sycp3-like Y-linked (Sly) e ncodes an abundant spermatid protein that interacts with a histone acetyltransf erase and an acrosomal protein. (PubMed id 19176879)1 Reynard L.N....Burgoyne P.S. (2009)
- An empirical framework for binary interactome mapping . (PubMed id 19060904)1 Venkatesan K....Vidal M. (2009)
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External Searches for APPBP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing APPBP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing APPBP2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing APPBP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for APPBP2 gene:
Search GeneIP for patents involving APPBP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for APPBP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for APPBP2 | | OriGene Custom Protein Services for APPBP2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat APPBP2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing APPBP2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APPBP2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APPBP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APPBP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APPBP2 |
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| |  |  |  |  | | | | |
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 | | | APPBP2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APPBP2 |
|  |  |  | | | | ThermoFisher Antibodies for APPBP2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APPBP2 |
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