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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

APPBP2 Gene

protein-coding   GIFtS: 56
GCID: GC17M058520

Amyloid Beta Precursor Protein (Cytoplasmic Tail) Binding...

(Previous name: amyloid beta precursor protein (cytoplasmic tail)-binding...)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Amyloid Beta Precursor Protein (Cytoplasmic Tail) Binding Protein 21 2     HS.840842
Protein Interacting With APP Tail 11 2 3     Amyloid Protein-Binding Protein 22
PAT12 3 5     KIAA02283
APP-BP22 3     Amyloid Beta Precursor Protein-Binding Protein 23
Amyloid Beta Precursor Protein (Cytoplasmic Tail)-Binding Protein 21     

External Ids:    HGNC: 6221   Entrez Gene: 105132   Ensembl: ENSG000000627257   OMIM: 6053245   UniProtKB: Q926243   

Export aliases for APPBP2 gene to outside databases

Previous GC identifers: GC17M058257 GC17M060971 GC17M058862 GC17M058994 GC17M055875 GC17M053891


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for APPBP2 Gene:
The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid
precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with
signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. The
encoded protein may be involved in regulating cell death. This gene has been found to be highly expressed in
breast cancer. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Sep 2013)

GeneCards Summary for APPBP2 Gene: 
APPBP2 (amyloid beta precursor protein (cytoplasmic tail) binding protein 2) is a protein-coding gene. Diseases associated with APPBP2 include alzheimer's disease, and breast cancer. GO annotations related to this gene include protein binding and microtubule motor activity.

UniProtKB/Swiss-Prot: APBP2_HUMAN, Q92624
Function: May play a role in intracellular protein transport. May be involved in the translocation of APP along
microtubules toward the cell surface

Gene Wiki entry for APPBP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the APPBP2 gene promoter:
         HTF   CUTL1   GATA-1   RORalpha2   POU2F1   POU2F1a   SEF-1 (1)   MRF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAPPBP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for APPBP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APPBP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.2   Ensembl cytogenetic band:  17q23.2   HGNC cytogenetic band: 17q23.2

APPBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APPBP2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M058520:  view genomic region     (about GC identifiers)

Start:
58,520,520 bp from pter      End:
58,603,580 bp from pter
Size:
83,061 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: APBP2_HUMAN, Q92624 (See protein sequence)
Recommended Name: Amyloid protein-binding protein 2  
Size: 585 amino acids; 66853 Da
Subunit: Binds APP
Subcellular location: Nucleus. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein (Potential).
Note=Associated with membranes and microtubules
Sequence caution: Sequence=BAA13217.1; Type=Erroneous initiation;
Secondary accessions: A8K862 O95095 Q8WVC9

Explore the universe of human proteins at neXtProt for APPBP2: NX_Q92624

Explore proteomics data for APPBP2 at MOPED 

Post-translational modifications:

  • UniProtKB: Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92624

  • APPBP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    APPBP2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001269405.1  NP_006371.2  

    ENSEMBL proteins: 
     ENSP00000083182   ENSP00000467025   ENSP00000466802   ENSP00000464962  

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    Cloud-Clone Corp. Proteins for APPBP2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS11742091
    GO:0005737cytoplasm NAS11742091
    GO:0005874microtubule IEA--
    GO:0005875microtubule associated complex TAS9843960
    GO:0030659cytoplasmic vesicle membrane IDA9843960

    APPBP2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry Q92624

    ProtoNet protein and cluster: Q92624

    UniProtKB/Swiss-Prot: APBP2_HUMAN, Q92624
    Similarity: Contains 8 TPR repeats


    APPBP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APBP2_HUMAN, Q92624
    Function: May play a role in intracellular protein transport. May be involved in the translocation of APP along
    microtubules toward the cell surface

         Genatlas biochemistry entry for APPBP2:
    amyloid beta precursor protein binding protein 2, cytoplasmic,also associating with membranes cofractionating with
    APP vesicle,interacting with microtubule,binding the basolateral sorting signal in the cytoplasmic tail of APP

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777microtubule motor activity TAS9843960
    GO:0005515protein binding IPI16189514
         
    APPBP2 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for APPBP2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of Androgen receptor activity
    Regulation of Androgen receptor activity


    1 BioSystems Pathway for APPBP2
        Regulation of Androgen receptor activity


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for APPBP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/77 Interacting proteins for APPBP2 (Q926241, 2, 3 ENSP000000831824) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313I2D: score=1 
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    HIST1H3EP684313I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport TAS9843960
    GO:0046907intracellular transport IDA9843960

    APPBP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for APPBP2 (APBP2)

    Search CenterWatch for drugs/clinical trials and news about APPBP2 / APBP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for APPBP2 gene (2 alternative transcripts): 
    NM_001282476.1  NM_006380.3  

    Unigene Cluster for APPBP2:

    Amyloid beta precursor protein (cytoplasmic tail) binding protein 2
    Hs.84084  [show with all ESTs]
    Unigene Representative Sequence: NM_006380
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000083182(uc002iys.1 uc010ddl.1) ENST00000589341 ENST00000592995
    ENST00000590244 ENST00000588668 ENST00000585368

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    hsa-miR-579 hsa-miR-640 hsa-miR-3938 hsa-miR-300 hsa-miR-631 hsa-miR-605 hsa-miR-1245 hsa-miR-200a
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    Additional mRNA sequence: 

    AF017782.1 AK292227.1 AK307666.1 BC018121.1 D86981.1 

    9 DOTS entries:

    DT.453197  DT.95307307  DT.95183631  DT.75184561  DT.120980652  DT.95307305  DT.95307306  DT.120980653 
    DT.91908113 

    24/231 AceView cDNA sequences (see all 231):

    AL596945 BM722548 AL079557 BM829186 BM679055 AI889958 BQ018406 AL046686 
    AW082207 CK818889 BE463901 BQ014603 BU182403 AL040265 AI862699 BM126300 
    BM055428 AL542614 BU621440 CD723163 AW070505 AA431206 BM830969 AI887670 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    APPBP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    APPBP2 Expression
    About this image


    See APPBP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for APPBP2

    SOURCE GeneReport for Unigene cluster: Hs.84084
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for APPBP2 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Appbp21 , 5 amyloid beta precursor protein (cytoplasmic tail) binding more1, 5 91.28(n)1
    99.15(a)1
      11 (51.34 cM)5
    668841  NM_025825.31  NP_080101.11 
     851872625 
    chicken
    (Gallus gallus)
    Aves APPBP21 amyloid beta precursor protein (cytoplasmic tail) binding more 84.65(n)
    96.4(a)
      417645  NM_001030723.1  NP_001025894.1 
    lizard
    (Anolis carolinensis)
    Reptilia APPBP26
    Uncharacterized protein
    92(a)
    1 ↔ 1
    GL343393.1(484163-500360)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.237962 Xenopus laevis transcribed sequence with moderate similarity more 80.85(n)    BG485979.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb78e112 Transcribed sequence with moderate similarity to protein more 77(n)    57047764 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG106953
    Pat11
    microtubule-based movement kinesin
    motor3
    Protein interacting with APP tail-11
    47(a)3
    51.05(n)1
    47.93(a)1
      6C13
    315931  NM_132100.31  NP_572328.11 


    ENSEMBL Gene Tree for APPBP2 (if available)
    TreeFam Gene Tree for APPBP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1814 SNPs in APPBP2 are shown (see all 1814)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2015475401,2
    C--58527306(+) GCGTA-/CTGTAC 1 -- int10--------
    rs571133051,2
    C--58601998(+) AAAAA-/A/AA  
     AAAAAAA
    TCTAG
    2 -- int1 cds12NA 4
    rs1892363201,2
    --59535350(+) ATTCAC/TGTGAG 1 -- ds50010--------
    rs72113401,2
    C,F,H--59535374(+) AAGAGG/AGCTGG 1 -- ds500112Minor allele frequency- A:0.11NS EA NA WA 1310
    rs1807826231,2
    --59535469(+) CTTTAC/TCAGGT 1 -- ds50010--------
    rs1850060681,2
    --59535503(+) AGAGTC/GAGAGG 1 -- ds50010--------
    rs1910304071,2
    --59535556(+) CCTTTC/GCATTA 1 -- ds50010--------
    rs571235171,2
    C--59535575(+) CTTTGC/TCTTTT 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1818524871,2
    --59535584(+) TTTCCA/GAGTGC 1 -- ds50010--------
    rs1508609191,2
    --59535624(+) CATGCA/GCCTCC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for APPBP2 (58520520 - 58603580 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for APPBP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2677176CNV Deletion23128226
    esv2671823CNV Deletion23128226
    esv1010187CNV Insertion20482838
    nsv828080CNV Loss20364138
    esv29677CNV Loss19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605324    OMIM disorders: --

    3 diseases for APPBP2:    About MalaCards
    alzheimer's disease    breast cancer    herpes simplex


    APPBP2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): APPBP2

    Export disorders for APPBP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for APPBP2 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with APPBP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein. (PubMed id 9843960)1, 2, 3, 9 Zheng P.... Pimplikar S.W. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus. (PubMed id 11742091)1, 2 Gao Y. and Pimplikar S.W. (2001)
    4. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T....Nomura N. (1996)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    6. PAT1 induces cell death signal and SET mislocalization into the cytoplasm by increasing APP/APLP2 at the cell surface. (PubMed id 19570594)1 Briand S....Allinquant B. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Pat1 proteins: a life in translation, translation repr ession and mRNA decay. (PubMed id 21118134)1 Marnef A. and Standart N. (2010)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10513 HGNC: 622 AceView: APPBP2 Ensembl:ENSG00000062725 euGenes: HUgn10513
    ECgene: APPBP2 H-InvDB: APPBP2

    (According to HUGE)
    About This Section
    HUGE: KIAA0228

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for APPBP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for APPBP2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for APPBP2 gene:
    Search GeneIP for patents involving APPBP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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