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Aliases for APPBP2 Gene

Aliases for APPBP2 Gene

  • Amyloid Beta Precursor Protein Binding Protein 2 2 3
  • Amyloid Beta Precursor Protein (Cytoplasmic Tail) Binding Protein 2 2 3 5
  • Protein Interacting With APP Tail 1 2 3 4
  • APP-BP2 3 4
  • PAT1 3 4
  • Amyloid Beta Precursor Protein (Cytoplasmic Tail)-Binding Protein 2 2
  • Amyloid Beta Precursor Protein-Binding Protein 2 4
  • HS.84084 3
  • KIAA0228 4

External Ids for APPBP2 Gene

Previous GeneCards Identifiers for APPBP2 Gene

  • GC17M058257
  • GC17M060971
  • GC17M058862
  • GC17M058994
  • GC17M055875
  • GC17M058520
  • GC17M053891

Summaries for APPBP2 Gene

Entrez Gene Summary for APPBP2 Gene

  • The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. The encoded protein may be involved in regulating cell death. This gene has been found to be highly expressed in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for APPBP2 Gene

APPBP2 (Amyloid Beta Precursor Protein Binding Protein 2) is a Protein Coding gene. Among its related pathways are Regulation of Androgen receptor activity. GO annotations related to this gene include microtubule motor activity.

UniProtKB/Swiss-Prot for APPBP2 Gene

  • May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.

Gene Wiki entry for APPBP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APPBP2 Gene

Genomics for APPBP2 Gene

Regulatory Elements for APPBP2 Gene

Enhancers for APPBP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around APPBP2 on UCSC Golden Path with GeneCards custom track

Promoters for APPBP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around APPBP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for APPBP2 Gene

60,443,149 bp from pter
60,526,240 bp from pter
83,092 bases
Minus strand

Genomic View for APPBP2 Gene

Genes around APPBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APPBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APPBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APPBP2 Gene

Proteins for APPBP2 Gene

  • Protein details for APPBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Amyloid protein-binding protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K862
    • O95095
    • Q8WVC9

    Protein attributes for APPBP2 Gene

    585 amino acids
    Molecular mass:
    66853 Da
    Quaternary structure:
    • Binds APP.
    • Sequence=BAA13217.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for APPBP2 Gene

Proteomics data for APPBP2 Gene at MOPED

Post-translational modifications for APPBP2 Gene

  • Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP.
  • Ubiquitination at Lys 379, Lys 430, and Lys 522
  • Modification sites at PhosphoSitePlus

Other Protein References for APPBP2 Gene

No data available for DME Specific Peptides for APPBP2 Gene

Domains & Families for APPBP2 Gene

Protein Domains for APPBP2 Gene

Suggested Antigen Peptide Sequences for APPBP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 8 TPR repeats.
  • Contains 8 TPR repeats.
genes like me logo Genes that share domains with APPBP2: view

No data available for Gene Families for APPBP2 Gene

Function for APPBP2 Gene

Molecular function for APPBP2 Gene

GENATLAS Biochemistry:
amyloid beta precursor protein binding protein 2, cytoplasmic,also associating with membranes cofractionating with APP vesicle,interacting with microtubule,binding the basolateral sorting signal in the cytoplasmic tail of APP
UniProtKB/Swiss-Prot Function:
May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.
genes like me logo Genes that share phenotypes with APPBP2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for APPBP2 Gene

Localization for APPBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APPBP2 Gene

Nucleus. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Associated with membranes and microtubules.

Subcellular locations from

Jensen Localization Image for APPBP2 Gene COMPARTMENTS Subcellular localization image for APPBP2 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for APPBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005875 microtubule associated complex TAS 9843960
GO:0030659 cytoplasmic vesicle membrane IDA 9843960
genes like me logo Genes that share ontologies with APPBP2: view

Pathways & Interactions for APPBP2 Gene

genes like me logo Genes that share pathways with APPBP2: view

Pathways by source for APPBP2 Gene

1 BioSystems pathway for APPBP2 Gene

Gene Ontology (GO) - Biological Process for APPBP2 Gene


No data available for SIGNOR curated interactions for APPBP2 Gene

Drugs & Compounds for APPBP2 Gene

No Compound Related Data Available

Transcripts for APPBP2 Gene

Unigene Clusters for APPBP2 Gene

Amyloid beta precursor protein (cytoplasmic tail) binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APPBP2 Gene

No ASD Table

Relevant External Links for APPBP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for APPBP2 Gene

mRNA expression in normal human tissues for APPBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for APPBP2 Gene

This gene is overexpressed in Plasma (66.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for APPBP2 Gene

SOURCE GeneReport for Unigene cluster for APPBP2 Gene Hs.84084

genes like me logo Genes that share expression patterns with APPBP2: view

Protein tissue co-expression partners for APPBP2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for APPBP2 Gene

Orthologs for APPBP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for APPBP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia APPBP2 35
  • 95.73 (n)
  • 98.8 (a)
  • 99 (a)
(Canis familiaris)
Mammalia APPBP2 35
  • 95.78 (n)
  • 99.49 (a)
  • 99 (a)
(Mus musculus)
Mammalia Appbp2 35
  • 91.28 (n)
  • 99.15 (a)
Appbp2 16
Appbp2 36
  • 99 (a)
(Pan troglodytes)
Mammalia APPBP2 35
  • 99.94 (n)
  • 99.83 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Appbp2 35
  • 90.2 (n)
  • 98.8 (a)
(Monodelphis domestica)
Mammalia APPBP2 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia APPBP2 36
  • 97 (a)
(Gallus gallus)
Aves APPBP2 35
  • 84.65 (n)
  • 96.4 (a)
  • 96 (a)
(Anolis carolinensis)
Reptilia APPBP2 36
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia appbp2 35
  • 79.2 (n)
  • 93.85 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23796 35
(Danio rerio)
Actinopterygii appbp2 35
  • 77.2 (n)
  • 93.44 (a)
wufb78e11 35
appbp2 36
  • 92 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10695 37
  • 47 (a)
Pat1 35
  • 52.06 (n)
  • 49.54 (a)
Pat1 36
  • 37 (a)
Species with no ortholog for APPBP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APPBP2 Gene

Gene Tree for APPBP2 (if available)
Gene Tree for APPBP2 (if available)

Paralogs for APPBP2 Gene

No data available for Paralogs for APPBP2 Gene

Variants for APPBP2 Gene

Sequence variations from dbSNP and Humsavar for APPBP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs34146848 - 60,447,657(+) TGGTG(C/T)TGACA reference, missense
rs1051258 -- 60,461,858(-) GGGTT(C/G)TACTT reference, missense
rs1051259 -- 60,460,750(-) TGGCA(A/G)AAATA reference, missense
rs1051260 -- 60,460,713(-) TTGGC(A/C/G)TACTC reference, synonymous-codon
rs1051261 -- 60,460,705(-) CTCTT(C/G)TTATG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for APPBP2 Gene

Variant ID Type Subtype PubMed ID
esv1010187 CNV Insertion 20482838
esv2671823 CNV Deletion 23128226
esv29677 CNV Loss 19812545
esv2677176 CNV Deletion 23128226
nsv828080 CNV Loss 20364138

Variation tolerance for APPBP2 Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.50; 77.62% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for APPBP2 Gene

Disorders for APPBP2 Gene

Relevant External Links for APPBP2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for APPBP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APPBP2 Gene

Publications for APPBP2 Gene

  1. PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein. (PMID: 9843960) Zheng P. … Pimplikar S.W. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 23 67
  2. Amyloid-I^ precursor protein facilitates the regulator of calcineurin 1-mediated apoptosis by downregulating proteasome subunit I+ type-5 and proteasome subunit I^ type-7. (PMID: 25194880) Wu Y. … Song W. (Neurobiol. Aging 2015) 3
  3. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for APPBP2 Gene

Sources for APPBP2 Gene