APOPT1 Gene
protein-coding GIFtS: 35
GCID: GC14P104032
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apoptogenic 1, mitochondrial(Previous names: chromosome 14 open reading frame 153, apoptogenic 1 )
(Previous symbol: C14orf153)
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Aliases
for APOPT1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Apoptogenic 1, Mitochondrial1 2 | | Apoptogenic 11 | | C14orf1531 2 3 | | Chromosome 14 Open Reading Frame 1531 | | APOP-11 3 | | Apoptogenic Protein 1, Mitochondrial2 | | APOP12 3 | | UPF0671 Protein C14orf1532 | | MGC25621 | | |
Export aliases for APOPT1 gene to outside databases |
Summaries
for APOPT1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: APOP1_HUMAN, Q96IL0Function: Plays a role in the regulation of apoptosis. Mediates mitochondria-induced cell death in vascular smoothmuscle cells through the release of cytochrome c from mitochondria, followed by the activation of the caspase cascade(By similarity)
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Genomic Views
for APOPT1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for APOPT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for APOPT1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOPT1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32.33 Ensembl cytogenetic band: 14q32.33 HGNC cytogenetic band: 14q32.33APOPT1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P104032: view genomic region
(about GC identifiers)
Start:
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104,029,299 bp from pter |
End:
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104,073,860 bp from pter |
Size:
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44,562 bases |
Orientation:
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plus strand |
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Proteins
for APOPT1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: APOP1_HUMAN, Q96IL0 (See
protein sequence)Recommended Name: Apoptogenic protein 1, mitochondrial precursor Size: 206 amino acids; 24153 Da
Subcellular location: Mitochondrion (By similarity)
Caution: It is uncertain whether Met-1 or Met-14 is the initiator
Sequence caution: Sequence=AAH07412.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAD96812.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAD96823.1;Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q53G28Explore the universe of human proteins at neXtProt for APOPT1: NX_Q96IL0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96IL0
APOPT1 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_115750.2
ENSEMBL proteins: ENSP00000386485 ENSP00000388067 ENSP00000408525 ENSP00000451788 ENSP00000451703 ENSP00000450756
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- |
APOPT1 for ontologies About GeneDecksing
APOPT1 Antibody Products:
Assay Products for APOPT1: |
Protein
Domains /
Families
for APOPT1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
APOPT1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96IL0ProtoNet protein and cluster: Q96IL0 UniProtKB/Swiss-Prot: APOP1_HUMAN, Q96IL0Similarity: Belongs to the APOPT family |
Function
for APOPT1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: APOP1_HUMAN, Q96IL0Function: Plays a role in the regulation of apoptosis. Mediates mitochondria-induced cell death in vascular smoothmuscle cells through the release of cytochrome c from mitochondria, followed by the activation of the caspase cascade(By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APOPT1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APOPT1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for APOPT1 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for APOPT1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOPT1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOPT1 |
|
Pathways & Interactions
for APOPT1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for APOPT1
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0034393 | positive regulation of smooth muscle cell apoptotic process |
IEA | -- | | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
IEA | -- | | GO:0090200 | positive regulation of release of cytochrome c from mitochondria |
IEA | -- | | GO:0097193 | intrinsic apoptotic signaling pathway |
IEA | -- |
APOPT1 for ontologies About GeneDecksing
|
Drugs & Compounds
for APOPT1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for APOPT1
Search CenterWatch for drugs/clinical trials and news about APOPT1 / APOP1
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Transcripts
for APOPT1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for APOPT1 gene: NM_032374.3 Unigene Cluster for APOPT1: Apoptogenic 1, mitochondrial Hs.598441 [show with all ESTs]Unigene Representative Sequence: BC00741213 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000409074(uc010tyc.2) ENST00000440963 ENST00000458117 ENST00000489117
ENST00000495778 ENST00000492189 ENST00000477116 ENST00000473127 ENST00000497901
ENST00000476323 ENST00000555660 ENST00000474271 ENST00000557079
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APOPT1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APOPT1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for APOPT1 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for APOPT1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOPT1 |
Additional cDNA sequence: AK024310.1 AK223092.1 AK223103.1 BC007412.2 15 DOTS entries: DT.40220816 DT.92422925 DT.100818258 DT.100818256 DT.91931566 DT.120790773 DT.87015727 DT.120790772 DT.120790955 DT.100001314 DT.120790667 DT.100818257 DT.120790845 DT.92422926 DT.95168726 24/140 AceView cDNA sequences (see all 140): BM791560 BX119699 AA594412 CR619996 BM712571 AI268564 CB993873 AI138918 CA419056 BF195110 AW955447 CD674947 BM662212 AA336706 BE778409 NM_032374 BU956674 AA768017 BC007412 BU633274 AA115938 AI273675 AA121006 AW963964
GeneLoc Exon Structure
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Expression
for APOPT1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| APOPT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
Genevestigator expression for APOPT1
SOURCE GeneReport for Unigene cluster: Hs.598441
SABiosciences Custom PCR Arrays for APOPT1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for APOPT1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat APOPT1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APOPT1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APOPT1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOPT1 |
Orthologs
for APOPT1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for APOPT1 gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for APOPT1 (if available)
TreeFam Gene Tree for APOPT1 (if available) |
Paralogs
for APOPT1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for APOPT1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for APOPT1 (104029299 - 104073860 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for APOPT1: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for APOPT1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
APOPT1 for disorders About GeneDecksing
2  diseases for APOPT1: About MalaCardsintrahepatic cholangiocarcinoma cholangiocarcinoma
Export disorders for APOPT1 gene to outside databases
|
Publications
for APOPT1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for APOPT1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with APOPT1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Akt activation prevents Apop-1-induced death of cells . (PubMed id 18977203)1, 3 Sun X....Rakugi H. (2008)
- Apop-1, a novel protein inducing cyclophilin D-depend ent but Bax/Bak-related channel-independent apoptosis. (PubMed id 16782708)1, 3 Yasuda O....Ogihara T. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)2 Wang A.G....Kim N.S. (2006)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
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External Searches for APOPT1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing APOPT1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing APOPT1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing APOPT1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for APOPT1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for APOPT1 gene:
Search GeneIP for patents involving APOPT1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for APOPT1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for APOPT1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APOPT1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for APOPT1 | | | OriGene Protein Over-expression Lysate for APOPT1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for APOPT1 | | OriGene 3'-UTR Clone for APOPT1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APOPT1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APOPT1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for APOPT1 | | OriGene Custom Protein Services for APOPT1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat APOPT1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing APOPT1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOPT1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APOPT1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APOPT1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APOPT1 |
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 |  |  |  | |
| | | | Search Tocris compounds for APOPT1 |
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 | | | APOPT1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOPT1 |
|  |  |  | | | | Search ThermoFisher Antibodies for APOPT1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOPT1 |
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