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Aliases for APOO Gene

Aliases for APOO Gene

  • Apolipoprotein O 2 3 4 5
  • Family With Sequence Similarity 121B 2 3
  • MICOS Complex Subunit MIC23 3 4
  • FAM121B 3 4
  • Mic23 3 4
  • MIC26 3 4
  • Protein FAM121B 4
  • Brain My025 3
  • My025 3

External Ids for APOO Gene

Previous HGNC Symbols for APOO Gene

  • FAM121B

Previous GeneCards Identifiers for APOO Gene

  • GC0XM023763
  • GC0XM021597

Summaries for APOO Gene

Entrez Gene Summary for APOO Gene

  • This gene is a member of the apolipoprotein family. Members of this protein family are involved in the transport and metabolism of lipids. The encoded protein associates with HDL, LDL and VLDL lipoproteins and is characterized by chondroitin-sulfate glycosylation. This protein may be involved in preventing lipid accumulation in the myocardium in obese and diabetic patients. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 4, 5, 12 and 16.[provided by RefSeq, Sep 2009]

GeneCards Summary for APOO Gene

APOO (Apolipoprotein O) is a Protein Coding gene. An important paralog of this gene is APOOL.

UniProtKB/Swiss-Prot for APOO Gene

  • Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:25764979). Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (PubMed:16956892).

Gene Wiki entry for APOO Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOO Gene

Genomics for APOO Gene

Regulatory Elements for APOO Gene

Promoters for APOO Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around APOO on UCSC Golden Path with GeneCards custom track

Genomic Location for APOO Gene

Chromosome:
X
Start:
23,833,348 bp from pter
End:
23,907,940 bp from pter
Size:
74,593 bases
Orientation:
Minus strand

Genomic View for APOO Gene

Genes around APOO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOO Gene

Proteins for APOO Gene

  • Protein details for APOO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUR5-MIC26_HUMAN
    Recommended name:
    MICOS complex subunit MIC26
    Protein Accession:
    Q9BUR5
    Secondary Accessions:
    • B2R4K9
    • Q9H3J9

    Protein attributes for APOO Gene

    Size:
    198 amino acids
    Molecular mass:
    22285 Da
    Quaternary structure:
    • Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9 (PubMed:25764979, PubMed:25781180, PubMed:25997101). Interacts with IMMT/MIC60 (PubMed:25764979, PubMed:25781180). Interacts with MINOS1/MIC10 and APOOL/MIC27 (PubMed:25764979).

    Alternative splice isoforms for APOO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for APOO Gene

Proteomics data for APOO Gene at MOPED

Post-translational modifications for APOO Gene

Other Protein References for APOO Gene

Antibody Products

No data available for DME Specific Peptides for APOO Gene

Domains & Families for APOO Gene

Gene Families for APOO Gene

Protein Domains for APOO Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for APOO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BUR5

UniProtKB/Swiss-Prot:

MIC26_HUMAN :
  • Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
Family:
  • Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
genes like me logo Genes that share domains with APOO: view

Function for APOO Gene

Molecular function for APOO Gene

UniProtKB/Swiss-Prot Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:25764979). Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (PubMed:16956892).
genes like me logo Genes that share phenotypes with APOO: view

Animal Model Products

CRISPR Products

miRNA for APOO Gene

miRTarBase miRNAs that target APOO

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for APOO Gene

Localization for APOO Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOO Gene

Mitochondrion inner membrane; Single-pass membrane protein. Secreted. Mitochondrion. Golgi apparatus membrane. Endoplasmic reticulum membrane. Note=Exists in three distinct forms: a glycosylated and secreted form, an ER/Golgi-resident form and a non-glycosylated mitochondrial form. {ECO:0000269 PubMed:25764979}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOO Gene COMPARTMENTS Subcellular localization image for APOO gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
golgi apparatus 5
mitochondrion 5
cytosol 3
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for APOO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IDA 25764979
GO:0005739 mitochondrion IDA 20833797
GO:0005789 endoplasmic reticulum membrane IDA 25764979
GO:0016021 integral component of membrane IEA --
GO:0031305 integral component of mitochondrial inner membrane IDA 25764979
genes like me logo Genes that share ontologies with APOO: view

Pathways & Interactions for APOO Gene

SuperPathways for APOO Gene

No Data Available

Interacting Proteins for APOO Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000368528%0d%0a9606.ENSP00000266970%0d%0a
Selected Interacting proteins: ENSP00000368528 for APOO Gene via STRING

Symbol External ID(s) Details
CDK2

Gene Ontology (GO) - Biological Process for APOO Gene

None

No data available for Pathways by source and SIGNOR curated interactions for APOO Gene

Drugs & Compounds for APOO Gene

No Compound Related Data Available

Transcripts for APOO Gene

Unigene Clusters for APOO Gene

Apolipoprotein O:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APOO Gene

No ASD Table

Relevant External Links for APOO Gene

GeneLoc Exon Structure for
APOO
ECgene alternative splicing isoforms for
APOO

Expression for APOO Gene

mRNA expression in normal human tissues for APOO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for APOO Gene

This gene is overexpressed in Brain (10.2) and Heart (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for APOO Gene



SOURCE GeneReport for Unigene cluster for APOO Gene Hs.495851

mRNA Expression by UniProt/SwissProt for APOO Gene

Q9BUR5-MIC26_HUMAN
Tissue specificity: Expressed in all tissues examined. Up-regulated in diabetic heart.
genes like me logo Genes that share expression patterns with APOO: view

Protein tissue co-expression partners for APOO Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for APOO Gene

Orthologs for APOO Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOO Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia APOO 35
  • 89.9 (n)
  • 86.87 (a)
APOO 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia APOO 35
  • 91.25 (n)
  • 90.4 (a)
APOO 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Apoo 35
  • 86.53 (n)
  • 82.83 (a)
Apoo 16
Apoo 36
  • 76 (a)
OneToMany
Apoo-ps 36
  • 83 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia APOO 35
  • 99.49 (n)
  • 99.49 (a)
APOO 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Apoo 35
  • 85.19 (n)
  • 80.3 (a)
oppossum
(Monodelphis domestica)
Mammalia APOO 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia APOO 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves APOO 35
  • 67.2 (n)
  • 58.29 (a)
APOO 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia apoo 35
  • 59.89 (n)
  • 49.73 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2586 35
zebrafish
(Danio rerio)
Actinopterygii apooa 35
  • 52.91 (n)
  • 48.15 (a)
apooa 36
  • 42 (a)
OneToMany
apoob 36
  • 30 (a)
OneToMany
Species with no ortholog for APOO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APOO Gene

ENSEMBL:
Gene Tree for APOO (if available)
TreeFam:
Gene Tree for APOO (if available)

Paralogs for APOO Gene

Paralogs for APOO Gene

(2) SIMAP similar genes for APOO Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with APOO: view

Variants for APOO Gene

Sequence variations from dbSNP and Humsavar for APOO Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs4852 -- 23,833,456(+) AGGTT(A/G)GTTTG nc-transcript-variant, utr-variant-3-prime
rs8680 -- 23,840,335(+) GCATG(A/G)AGTTT nc-transcript-variant, utr-variant-3-prime
rs2106423 -- 23,890,722(-) actca(A/G)aacac intron-variant
rs2106424 -- 23,890,693(-) gggca(A/G)aatca intron-variant
rs2106425 -- 23,890,607(-) aagca(A/G)aatgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for APOO Gene

Variant ID Type Subtype PubMed ID
nsv6836 CNV Insertion 18451855

Variation tolerance for APOO Gene

Residual Variation Intolerance Score: 73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.55; 44.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for APOO Gene

HapMap Linkage Disequilibrium report
APOO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOO Gene

Disorders for APOO Gene

Relevant External Links for APOO

Genetic Association Database (GAD)
APOO
Human Genome Epidemiology (HuGE) Navigator
APOO
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APOO

No disorders were found for APOO Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APOO Gene

Publications for APOO Gene

  1. Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits. (PMID: 25781180) Ott C. … Kozjak-Pavlovic V. (PLoS ONE 2015) 2 3 4 67
  2. The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions. (PMID: 25764979) Koob S. … Reichert A.S. (Biochim. Biophys. Acta 2015) 2 3
  3. ApoO, a novel apolipoprotein, is an original glycoprotein up- regulated by diabetes in human heart. (PMID: 16956892) Lamant M. … Rouet P. (J. Biol. Chem. 2006) 2 3
  4. QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology. (PMID: 25997101) Guarani V. … Harper J.W. (Elife 2015) 3
  5. TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex. (PMID: 24344204) Guarani V. … Harper J.W. (Mol. Cell. Biol. 2014) 3

Products for APOO Gene

Sources for APOO Gene

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