Aliases for APOO Gene
External Ids for APOO Gene
Previous HGNC Symbols for APOO Gene
Previous GeneCards Identifiers for APOO Gene
This gene is a member of the apolipoprotein family. Members of this protein family are involved in the transport and metabolism of lipids. The encoded protein associates with HDL, LDL and VLDL lipoproteins and is characterized by chondroitin-sulfate glycosylation. This protein may be involved in preventing lipid accumulation in the myocardium in obese and diabetic patients. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 4, 5, 12 and 16.[provided by RefSeq, Sep 2009]
GeneCards Summary for APOO Gene
APOO (Apolipoprotein O) is a Protein Coding gene. An important paralog of this gene is APOOL.
UniProtKB/Swiss-Prot for APOO Gene
Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. May be involved in myocardium-protective mechanisms against lipid accumulation.