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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

APOO Gene

protein-coding   GIFtS: 46
GCID: GC0XM023851

apolipoprotein O

(Previous name: family with sequence similarity 121B )
(Previous symbol: FAM121B)
 Explore 2 diseases affiliated with
APOO via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for APOO    

Aliases
for APOO gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Apolipoprotein O1 2     My0251
FAM121B1 2 3 5     Brain My0252
Family With Sequence Similarity 121B1 2     Protein FAM121B3
MGC48251     MYO255

External Ids:    HGNC: 287271   Entrez Gene: 791352   Ensembl: ENSG000001848317   OMIM: 3007535   UniProtKB: Q9BUR53   
ORGUL members:         
NONCODE:n407133    

Export aliases for APOO gene to outside databases

Previous GC identifers: GC0XM023763 GC0XM021597


Summaries
for APOO gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for APOO:
This gene is a member of the apolipoprotein family. Members of this protein family are involved in the transport and
metabolism of lipids. The encoded protein associates with HDL, LDL and VLDL lipoproteins and is characterized by
chondroitin-sulfate glycosylation. This protein may be involved in preventing lipid accumulation in the myocardium in
obese and diabetic patients. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene
are found on chromosomes 3, 4, 5, 12 and 16.(provided by RefSeq, Sep 2009)

UniProtKB/Swiss-Prot: APOO_HUMAN, Q9BUR5
Function: Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal
triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently
transferred to HDL. May be involved in myocardium-protective mechanisms against lipid accumulation

Gene Wiki entry for APOO (Apolipoprotein O)


Genomic Views
for APOO gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167197.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the APOO gene promoter:
         Egr-3   SRF   Sp1   SRF (504 AA)   IRF-1   Egr-2   HEN1   IRF-2   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: APOO promoter sequence
   Search SABiosciences Chromatin IP Primers for APOO

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.11   Ensembl cytogenetic band:  Xp22.11   HGNC cytogenetic band: Xp22.11

APOO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOO gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM023851:  view genomic region     (about GC identifiers)

Start:
 23,851,465 bp from pter      End:
 23,926,057 bp from pter
Size:
 74,593 bases      Orientation:
 minus strand

Proteins
for APOO gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: APOO_HUMAN, Q9BUR5 (See protein sequence)
Recommended Name: Apolipoprotein O precursor  
Size: 198 amino acids; 22285 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential). Secreted
Secondary accessions: B2R4K9 Q9H3J9
Alternative splicing: 2 isoforms:  Q9BUR5-1   Q9BUR5-2   

Explore the universe of human proteins at neXtProt for APOO: NX_Q9BUR5

Post-translational modifications:

  • O-glycosylation; glycosaminoglycan of chondroitin-sulfate type1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BUR5

    • APOO Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_077027.1  
    ENSEMBL proteins: 
     ENSP00000368528   ENSP00000402557   ENSP00000434341   ENSP00000368522  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: APOO
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    Novus Biologicals APOO Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for APOO

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space ISS--
    GO:0016021integral to membrane IEA--
    GO:0034361very-low-density lipoprotein particle IEA--
    GO:0034362low-density lipoprotein particle IEA--
    GO:0034364high-density lipoprotein particle IEA--


    APOO for ontologies           About GeneDecksing



    APOO Antibody Products: 
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    Uscn Antibodies for APOO
    ThermoFisher Antibodies for APOO

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    Uscn ELISAs and CLIAs for APOO

    Protein Domains /
    Families
    for APOO gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    APOO for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR019166 Apolipoprotein_O

    Graphical View of Domain Structure for InterPro Entry Q9BUR5

    ProtoNet protein and cluster: Q9BUR5

    UniProtKB/Swiss-Prot: APOO_HUMAN, Q9BUR5
    Similarity: Belongs to the apolipoprotein O family


    Function
    for APOO gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: APOO_HUMAN, Q9BUR5
    Function: Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal
    triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently
    transferred to HDL. May be involved in myocardium-protective mechanisms against lipid accumulation

    miRNA
    Products:            		 OriGene 3'-UTR Clone: APOO
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APOO
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate APOO (see all 18):
    hsa-miR-181c hsa-miR-429 hsa-miR-4263 hsa-miR-20b* hsa-miR-3121-3p hsa-miR-200b hsa-miR-181b hsa-miR-181a
    SwitchGear 3'UTR luciferase reporter plasmid: APOO 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APOO
    OriGene shRNA RFP: APOO
    OriGene siRNA: APOO
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APOO

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for APOO

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APOO (see all 2)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: APOO (NM_024122)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOO 

    Cell Line
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    Search LifeMap BioReagents cell lines for APOO

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for APOO

    2 GenomeRNAi human phenotypes for APOO:
     Increased G1 DNA content  Increased cell size 


    Pathways & Interactions
    for APOO gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for APOO

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006869lipid transport IEA--


    APOO for ontologies           About GeneDecksing



    Drugs & Compounds
    for APOO gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for APOO
    Search CenterWatch for drugs/clinical trials and news about APOO 

    Transcripts
    for APOO gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for APOO gene: 
    NM_024122.4  

    Unigene Cluster for APOO:

    Apolipoprotein O
    Hs.495851  [show with all ESTs]
    Unigene Representative Sequence: NM_024122
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379226(uc004dax.3 uc004day.4) ENST00000476598 ENST00000439528
    ENST00000490078 ENST00000379220

    miRNA
    Products:             		 OriGene 3'-UTR Clone: APOO
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APOO
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate APOO (see all 18):
    hsa-miR-181c hsa-miR-429 hsa-miR-4263 hsa-miR-20b* hsa-miR-3121-3p hsa-miR-200b hsa-miR-181b hsa-miR-181a
    SwitchGear 3'UTR luciferase reporter plasmid: APOO 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APOO
    OriGene shRNA RFP: APOO
    OriGene siRNA: APOO
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APOO
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APOO (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APOO
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: APOO (NM_024122)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for APOO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOO 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for APOO
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat APOO
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APOO
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APOO

    Additional cDNA sequence: 

    AF061264.1 AK311865.1 AY359114.1 BC002333.2 BC010102.2 BC016814.1 NR_026545.2 

    8 DOTS entries:

    DT.415328  DT.91856113  DT.100645432  DT.95274582  DT.95299082  DT.100057054  DT.121289560  DT.75102813 

    24/120 AceView cDNA sequences (see all 120):

    BE266369 AI199007 AA689372 AA906634 BC010102 BC002333 NM_024122 AY359114 
    CF243092 BF431747 AA948373 AL552262 AA732719 BX099786 BM698725 CB105844 
    CD672752 BM702643 AA176696 BM695981 AA694531 AI452533 AA952958 AI807655 

    GeneLoc Exon Structure


    Expression
    for APOO gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    APOO expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGCTATTTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See APOO Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for APOO

    SOURCE GeneReport for Unigene cluster: Hs.495851

    UniProtKB/Swiss-Prot: APOO_HUMAN, Q9BUR5
    Tissue specificity: Expressed in all tissues examined. Up-regulated in diabetic heart

        SABiosciences Custom PCR Arrays for APOO
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for APOO
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat APOO
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APOO
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APOO
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for APOO

    Orthologs
    for APOO gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for APOO gene from 3/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves APOO1 apolipoprotein O 67.2(n)
    58.29(a)    		   418599  XM_416798.3  XP_416798.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.25862 Xenopus laevis transcribed sequence with weak similarity more 73.48(n)    BJ093852.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii apooa1 apolipoprotein O, a 52.23(n)
    47.42(a)    		   641319  NM_001037115.1  NP_001032192.1 


    ENSEMBL Gene Tree for APOO (if available)
    TreeFam Gene Tree for APOO (if available) 

    Paralogs
    for APOO gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for APOO gene
    APOOL2  
    2 SIMAP similar genes for APOO using alignment to 4 protein entries:     APOO_HUMAN (see all proteins):
    DKFZp779P1227    APOOL

    APOO for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for APOO (see all 6)
    PGOHUM00000239834 PGOHUM00000248903 PGOHUM00000238093 PGOHUM00000245560 PGOHUM00000235820


    Genomic Variants
    for APOO gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/819 NCBI SNPs in APOO are shown (see all 819)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1912572251,2
    		--23851146(+) AGGAGA/GTGACA 2 -- ds50010--------
    rs1385614591,2
    		--23851201(+) CTAATA/CATCGT 2 -- ds50010--------
    rs1491713811,2
    		C,--23851216(+) GAAACC/TGTATT 2 -- ds50010--------
    rs1830249861,2
    		--23851249(+) GCTAGA/TTATTG 2 -- ds50010--------
    rs1858472001,2
    		--23851266(+) CTCTCG/TGACTC 2 -- ds50010--------
    rs1909932711,2
    		--23851537(+) TAAGGC/GTTGTA 2 -- nc-transcript-variantut310--------
    rs48521,2
    		C,F,H,--23851573(+) AGGTTA/GGTTTG 2 -- nc-transcript-variantut317Minor allele frequency- G:0.10MN NS NA WA 978
    rs1831772321,2
    		--23851825(+) CAGGCA/GCGGTG 2 -- int10--------
    rs1889099931,2
    		--23851864(+) GAAGCC/TGAGGC 2 -- int10--------
    rs1923411551,2
    		--23852080(+) TGGGCA/GACAAG 2 -- int10--------

    HapMap Linkage Disequilibrium report for APOO (23851465 - 23926057 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for APOO: --
    Locus Specific Mutation Databases (LSDB): APOO

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing APOO
    DNA2.0 Custom Variant and Variant Library Synthesis for APOO

    Disorders / Diseases
    for APOO gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    APOO for disorders           About GeneDecksing

    OMIM gene information: 300753    OMIM disorders: --

    2 diseases for APOO:    About MalaCards
    obesity    cholesterol

    Human Genome Epidemiology (HuGE) Navigator: APOO (5 documents)

    Export disorders for APOO gene to outside databases

    Publications
    for APOO gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for APOO gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with APOO)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. ApoO, a novel apolipoprotein, is an original glycoprotein up- regulated by diabetes in human heart. (PubMed id 16956892)1, 2, 3 Lamant M....Rouet P. (2006)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Plasma apolipoprotein O level increased in the patient s with acute coronary syndrome. (PubMed id 22693255)1 Yu B.L....Zhao S.P. (2012)
    5. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project. (PubMed id 20877300)1 Perroud N....McGuffin P. (2010)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    9. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    10. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1 Chapuis J....Lambert J.C. (2009)

    External Searches for APOO gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing APOO gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79135 HGNC: 28727 AceView: MGC4825 Ensembl:ENSG00000184831 euGenes: HUgn79135
    ECgene: APOO H-InvDB: APOO

    Other Databases showing APOO gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing APOO gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for APOO Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for APOO gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for APOO gene:
    Search GeneIP for patents involving APOO

    GeneCards and IP:
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     EMD Millipore Custom Antibody & Bulk Services
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     Regulatory tfbs in APOO promoter
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     APOO Proteins, Antibodies, CLIAs, and ELISAs
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     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for APOO
     SwitchGear 3'UTR luciferase reporter plasmids for APOO
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOO
           
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