Aliases for APOO Gene
Aliases for APOO Gene
External Ids for APOO Gene
- HGNC: 28727
- Entrez Gene: 79135
- Ensembl: ENSG00000184831
- OMIM: 300753
- UniProtKB: Q9BUR5
Previous HGNC Symbols for APOO Gene
- FAM121B
Previous GeneCards Identifiers for APOO Gene
- GC0XM023763
- GC0XM021597
Summaries for APOO Gene
-
This gene is a member of the apolipoprotein family. Members of this protein family are involved in the transport and metabolism of lipids. The encoded protein associates with HDL, LDL and VLDL lipoproteins and is characterized by chondroitin-sulfate glycosylation. This protein may be involved in preventing lipid accumulation in the myocardium in obese and diabetic patients. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 4, 5, 12 and 16.[provided by RefSeq, Sep 2009]
GeneCards Summary for APOO Gene
APOO (Apolipoprotein O) is a Protein Coding gene. An important paralog of this gene is APOOL.
UniProtKB/Swiss-Prot for APOO Gene
-
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:25764979). Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (PubMed:16956892).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOO Gene
Genomics for APOO Gene
Regulatory Elements for APOO Gene
Enhancers for APOO Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around APOO on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the APOO gene promoter:
Regulatory Element Products
Genomic Location for APOO Gene
- Chromosome:
- X
- Start:
- 23,833,348 bp from pter
- End:
- 23,907,940 bp from pter
- Size:
- 74,593 bases
- Orientation:
- Minus strand
Genomic View for APOO Gene
Genes around APOO on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp22.11 by Ensembl
- Xp22.11 by Entrez Gene
- Xp22.11 by HGNC
APOO Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for APOO Gene
Proteins for APOO Gene
-
Protein details for APOO Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BUR5-MIC26_HUMAN
- Recommended name:
- MICOS complex subunit MIC26
- Protein Accession:
- Q9BUR5
- B2R4K9
- Q9H3J9
Protein attributes for APOO Gene
- Size:
- 198 amino acids
- Molecular mass:
- 22285 Da
- Quaternary structure:
-
- Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9 (PubMed:25764979, PubMed:25781180, PubMed:25997101). Interacts with IMMT/MIC60 (PubMed:25764979, PubMed:25781180). Interacts with MINOS1/MIC10 and APOOL/MIC27 (PubMed:25764979).
Protein Expression for APOO Gene
Post-translational modifications for APOO Gene
- O-glycosylation; glycosaminoglycan of chondroitin-sulfate type.
- Glycosylation at Ser162
- Modification sites at PhosphoSitePlus
Other Protein References for APOO Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
Abcam antibodies for APOO
-
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- antibodies-online Antibodies for APOO: See all 51
- GeneTex APOO antibody for APOO
Protein Products
-
OriGene Purified Proteins for APOO
- Search Origene for MassSpec and Protein Over-expression Lysates for APOO
- Origene Custom Protein Services for APOO
-
Cloud-Clone Corp. Proteins for APOO
- Search GeneTex for Proteins for APOO
No data available for DME Specific Peptides for APOO Gene
Domains & Families for APOO Gene
Gene Families for APOO Gene
- HGNC:
Protein Domains for APOO Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for APOO Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BUR5UniProtKB/Swiss-Prot:
MIC26_HUMAN :- Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
- Family:
-
- Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
Function for APOO Gene
Molecular function for APOO Gene
- UniProtKB/Swiss-Prot Function:
- Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:25764979). Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (PubMed:16956892).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25764979 |
Phenotypes for APOO Gene
- MGI mutant phenotypes for APOO:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for APOO:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability in esophageal squamous lineage
- Decreased shRNA abundance (Z-score < -2)
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased transferrin (TF) endocytosis
- Increased G1 DNA content
- Increased shRNA abundance (Z-score > 2)
- Increased transcriptional activity
- Increased cell size
Animal Models for APOO Gene
- MGI Knock Outs for APOO:
-
- Apoo tm1b(KOMP)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for APOO
-
-
ViGene Biosciences lentiviral particle packaged cDNA for APOO gene
-
ViGene Biosciences ready-to-package AAV shRNAs for APOO gene
- Search ViGene Biosciences for APOO
CRISPR Products
-
OriGene CRISPR knockouts for APOO
-
Santa Cruz Biotechnology (SCBT) CRISPR for APOO
- GenScript: Design CRISPR guide RNA sequences for APOO
miRNA for APOO Gene
- miRTarBase miRNAs that target APOO
miRNA Products
- Search ViGene Biosciences for APOO
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for APOO
- Browse OriGene Inhibitory RNA Products For APOO
-
ViGene Biosciences ready-to-package AAV shRNAs for APOO gene
Clone Products
- Sino Biological Human cDNA Clone for APOO
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for APOO
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APOO
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for APOO
-
ViGene Biosciences adenoviral particle packaged cDNA for APOO gene
-
ViGene Biosciences lentiviral particle packaged cDNA for APOO gene
-
ViGene Biosciences ready-to-package AAV shRNAs for APOO gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for APOO Gene
Localization for APOO Gene
Subcellular locations from UniProtKB/Swiss-Prot for APOO Gene
- Mitochondrion inner membrane; Single-pass membrane protein. Secreted. Mitochondrion. Golgi apparatus membrane. Endoplasmic reticulum membrane. Note=Exists in three distinct forms: a glycosylated and secreted form, an ER/Golgi-resident form and a non-glycosylated mitochondrial form. {ECO:0000269 PubMed:25764979}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| mitochondrion | 5 |
| endoplasmic reticulum | 5 |
| cytosol | 5 |
| golgi apparatus | 5 |
| plasma membrane | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IDA | 25764979 |
| GO:0005576 | extracellular region | IDA,IEA | 25764979 |
| GO:0005615 | extracellular space | ISS | 22261194 |
| GO:0005739 | mitochondrion | IDA,IEA | 20833797 |
| GO:0005743 | mitochondrial inner membrane | IEA | -- |
Pathways & Interactions for APOO Gene
No Data Available
Interacting Proteins for APOO Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0006869 | lipid transport | IEA | -- |
| GO:0042407 | cristae formation | IEA,IMP | 25764979 |
No data available for Pathways by source and SIGNOR curated interactions for APOO Gene
Transcripts for APOO Gene
mRNA/cDNA for APOO Gene
- (6) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (120) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for APOO
-
Santa Cruz Biotechnology (SCBT) CRISPR for APOO
- GenScript: Design CRISPR guide RNA sequences for APOO
miRNA Products
- Search ViGene Biosciences for APOO
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for APOO
- Browse OriGene Inhibitory RNA Products For APOO
-
ViGene Biosciences ready-to-package AAV shRNAs for APOO gene
Clone Products
- Sino Biological Human cDNA Clone for APOO
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for APOO
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APOO
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for APOO Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Adipose (Muscoskeletal System)
This gene is overexpressed in Brain (10.2) and Heart (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for APOO Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of APOO Gene:
APOOSOURCE GeneReport for Unigene cluster for APOO Gene:
Hs.495851mRNA Expression by UniProt/SwissProt for APOO Gene:
Q9BUR5-MIC26_HUMAN
Tissue specificity:
Expressed in all tissues examined. Up-regulated in diabetic heart.
Evidence on tissue expression from TISSUES for APOO Gene
- Nervous system(4.3)
- Lung(4.2)
- Skin(4.2)
- Heart(2.2)
Primer Products
-
OriGene qPCR primer pairs for APOO
-
OriGene qPCR primer pairs and template standards for APOO
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for APOO Gene
Orthologs for APOO Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | APOO 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | APOO 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | APOO 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Apoo 34 16 35 |
|
||
| Apoo-ps 35 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Apoo 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | APOO 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | APOO 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | APOO 34 35 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | apoo 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.2586 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | apooa 34 35 |
|
||
| apoob 35 |
|
OneToMany |
- Species where no ortholog for APOO was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for APOO Gene
(2) SIMAP similar genes for APOO Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for APOO Gene
Variants for APOO Gene
| SNP ID | Clin | Chr 0X pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000055829 | -- | 23,881,142(+) | TGATC(C/T)CAGCT | intron-variant | |
| rs1000121138 | -- | 23,889,201(+) | AAAGG(C/T)AGATT | intron-variant | |
| rs1000125879 | -- | 23,883,173(+) | CACCC(C/T)TGGGC | intron-variant | |
| rs1000131447 | -- | 23,858,426(+) | ATTCG(C/T)GTTCA | intron-variant | |
| rs1000187476 | -- | 23,889,930(+) | TGCTG(A/G)GATTA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2237e212 | CNV | gain | 25503493 |
| nsv1141055 | CNV | deletion | 24896259 |
| nsv6836 | CNV | insertion | 18451855 |
Residual Variation Intolerance Score:
73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.55;
44.40% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for APOO Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- APOO
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOO Gene
Disorders for APOO Gene
Relevant External Links for APOO
No disorders were found for APOO Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APOO Gene
Publications for APOO Gene
- The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions. (PMID: 25764979) Koob S. … Reichert A.S. (Biochim. Biophys. Acta 2015) 2 3 4 64
- Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits. (PMID: 25781180) Ott C. … Kozjak-Pavlovic V. (PLoS ONE 2015) 2 3 4 64
- ApoO, a novel apolipoprotein, is an original glycoprotein up- regulated by diabetes in human heart. (PMID: 16956892) Lamant M. … Rouet P. (J. Biol. Chem. 2006) 2 3 4 64
- QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology. (PMID: 25997101) Guarani V. … Harper J.W. (Elife 2015) 3 4 64
- Apolipoprotein O is mitochondrial and promotes lipotoxicity in heart. (PMID: 24743151) Turkieh A. … Smih F. (J. Clin. Invest. 2014) 3 4 64
Products for APOO Gene
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- Custom Antibody ServicesOriGene Antibodies for APOO
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- OriGene Purified Proteins for APOO
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- OriGene qPCR primer pairs and template standards for APOO
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- GenScript: Next-day shipping cDNA ORF clone for APOO in any vector
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- Novus Biologicals Antibodies for APOO
- Novus Biologicals proteins and lysates for APOO
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cloud-Clone Corp. Antibodies for APOO
- Cloud-Clone Corp. Proteins for APOO
- Cloud-Clone Corp Assay Kits for APOO
- antibodies-online Antibodies for APOO: See all 51
- antibodies-online Kits for APOO: See all 10
- Search antibodies-online for proteins
- Search antibodies-online for peptides
- GeneTex APOO antibody for APOO
- Search GeneTex for Proteins for APOO
- ViGene Biosciences adenoviral particle packaged cDNA for APOO gene
- ViGene Biosciences lentiviral particle packaged cDNA for APOO gene
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- Search ViGene Biosciences for APOO
- Horizon Cell Lines for APOO
- Cyagen custom Knockout/knockin (KOKI) mouse models for APOO
- VectorBuilder custom plasmid, inducible vectors for APOO
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APOO
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for APOO Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
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- (122) diseasecard
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- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer