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Aliases for APOO Gene

Aliases for APOO Gene

  • Apolipoprotein O 2 3 4 5
  • Family With Sequence Similarity 121B 2 3
  • MICOS Complex Subunit MIC23 3 4
  • FAM121B 3 4
  • Mic23 3 4
  • MIC26 3 4
  • MICOS Complex Subunit MIC26 3
  • Protein FAM121B 4
  • Brain My025 3
  • My025 3

External Ids for APOO Gene

Previous HGNC Symbols for APOO Gene

  • FAM121B

Previous GeneCards Identifiers for APOO Gene

  • GC0XM023763
  • GC0XM021597

Summaries for APOO Gene

Entrez Gene Summary for APOO Gene

  • This gene is a member of the apolipoprotein family. Members of this protein family are involved in the transport and metabolism of lipids. The encoded protein associates with HDL, LDL and VLDL lipoproteins and is characterized by chondroitin-sulfate glycosylation. This protein may be involved in preventing lipid accumulation in the myocardium in obese and diabetic patients. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 4, 5, 12 and 16.[provided by RefSeq, Sep 2009]

GeneCards Summary for APOO Gene

APOO (Apolipoprotein O) is a Protein Coding gene. An important paralog of this gene is APOOL.

UniProtKB/Swiss-Prot for APOO Gene

  • Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:25764979). Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (PubMed:16956892).

Gene Wiki entry for APOO Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOO Gene

Genomics for APOO Gene

Regulatory Elements for APOO Gene

Enhancers for APOO Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG023821 0.8 ENCODE 17.9 +85.3 85339 1.8 PKNOX1 FOXA2 FEZF1 ZNF121 ZNF366 ZNF362 ZEB2 REST ZFP69B PRDM6 APOO CXorf58 PIR60902 GC0XP023785 GC0XP023786
GH0XG024014 0.7 ENCODE 12.5 -107.1 -107063 0.8 ZNF146 MTA2 NR2F1 BACH1 ZNF664 ZFHX2 TARDBP IKZF1 PRDM10 RELB CXorf58 APOO KLHL15 GC0XP023953
GH0XG023896 1.6 FANTOM5 Ensembl ENCODE 5.3 +8.1 8146 6.0 PKNOX1 WRNIP1 ARID4B TCF12 GLIS2 ZNF143 FOS JUNB REST ZNF592 SAT1 ACOT9 LOC105373148 ENSG00000202272 ZFX APOO EIF2S3 CXorf58 RPL9P7
GH0XG023883 1.6 FANTOM5 Ensembl ENCODE 5.2 +23.8 23782 2.2 HDGF PKNOX1 ARID4B FEZF1 ZNF2 ZNF121 ZNF766 ZNF143 KLF7 FOS SAT1 ACOT9 ENSG00000202272 LOC105373148 APOO EIF2S3 ZFX CXorf58 RPL9P7
GH0XG023886 1 ENCODE 7.2 +19.7 19684 3.3 ATF1 E2F7 ARID4B SIN3A ZNF48 ZNF2 YY1 ELK1 CBX5 ZNF143 ENSG00000202272 LOC105373148 SAT1 ACOT9 APOO EIF2S3 CXorf58 RPL9P7
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around APOO on UCSC Golden Path with GeneCards custom track

Promoters for APOO Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000245344 240 1801 ARID4B SIN3A ZNF2 YY1 CBX5 ZNF207 ZNF143 KLF13 SP3 REST

Genomic Location for APOO Gene

Chromosome:
X
Start:
23,833,348 bp from pter
End:
23,907,940 bp from pter
Size:
74,593 bases
Orientation:
Minus strand

Genomic View for APOO Gene

Genes around APOO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOO Gene

Proteins for APOO Gene

  • Protein details for APOO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUR5-MIC26_HUMAN
    Recommended name:
    MICOS complex subunit MIC26
    Protein Accession:
    Q9BUR5
    Secondary Accessions:
    • B2R4K9
    • Q9H3J9

    Protein attributes for APOO Gene

    Size:
    198 amino acids
    Molecular mass:
    22285 Da
    Quaternary structure:
    • Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9 (PubMed:25764979, PubMed:25781180, PubMed:25997101). Interacts with IMMT/MIC60 (PubMed:25764979, PubMed:25781180). Interacts with MINOS1/MIC10 and APOOL/MIC27 (PubMed:25764979).

    Alternative splice isoforms for APOO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for APOO Gene

Post-translational modifications for APOO Gene

No data available for DME Specific Peptides for APOO Gene

Domains & Families for APOO Gene

Gene Families for APOO Gene

Protein Domains for APOO Gene

Suggested Antigen Peptide Sequences for APOO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BUR5

UniProtKB/Swiss-Prot:

MIC26_HUMAN :
  • Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
Family:
  • Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
genes like me logo Genes that share domains with APOO: view

Function for APOO Gene

Molecular function for APOO Gene

UniProtKB/Swiss-Prot Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:25764979). Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (PubMed:16956892).

Gene Ontology (GO) - Molecular Function for APOO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25764979
genes like me logo Genes that share ontologies with APOO: view
genes like me logo Genes that share phenotypes with APOO: view

Animal Models for APOO Gene

MGI Knock Outs for APOO:
  • Apoo tm1b(KOMP)Wtsi

Animal Model Products

CRISPR Products

miRNA for APOO Gene

miRTarBase miRNAs that target APOO

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for APOO

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for APOO Gene

Localization for APOO Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOO Gene

Mitochondrion inner membrane; Single-pass membrane protein. Secreted. Mitochondrion. Golgi apparatus membrane. Endoplasmic reticulum membrane. Note=Exists in three distinct forms: a glycosylated and secreted form, an ER/Golgi-resident form and a non-glycosylated mitochondrial form. {ECO:0000269 PubMed:25764979}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for APOO gene
Compartment Confidence
extracellular 5
mitochondrion 5
endoplasmic reticulum 5
cytosol 5
golgi apparatus 5
plasma membrane 1
nucleus 1

Gene Ontology (GO) - Cellular Components for APOO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IDA 25764979
GO:0005576 extracellular region IDA,IEA 25764979
GO:0005615 extracellular space ISS 22261194
GO:0005739 mitochondrion IDA,IEA 20833797
GO:0005743 mitochondrial inner membrane IEA --
genes like me logo Genes that share ontologies with APOO: view

Pathways & Interactions for APOO Gene

No Data Available

Gene Ontology (GO) - Biological Process for APOO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006869 lipid transport IEA --
GO:0042407 cristae formation IEA,IMP 25764979
genes like me logo Genes that share ontologies with APOO: view

No data available for Pathways by source and SIGNOR curated interactions for APOO Gene

Drugs & Compounds for APOO Gene

No Compound Related Data Available

Transcripts for APOO Gene

Unigene Clusters for APOO Gene

Apolipoprotein O:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for APOO

Alternative Splicing Database (ASD) splice patterns (SP) for APOO Gene

No ASD Table

Relevant External Links for APOO Gene

GeneLoc Exon Structure for
APOO
ECgene alternative splicing isoforms for
APOO

Expression for APOO Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for APOO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for APOO Gene

This gene is overexpressed in Brain (10.2) and Heart (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for APOO Gene



Protein tissue co-expression partners for APOO Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of APOO Gene:

APOO

SOURCE GeneReport for Unigene cluster for APOO Gene:

Hs.495851

mRNA Expression by UniProt/SwissProt for APOO Gene:

Q9BUR5-MIC26_HUMAN
Tissue specificity: Expressed in all tissues examined. Up-regulated in diabetic heart.

Evidence on tissue expression from TISSUES for APOO Gene

  • Nervous system(4.3)
  • Lung(4.2)
  • Skin(4.2)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with APOO: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for APOO Gene

Orthologs for APOO Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APOO 34 35
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia APOO 34 35
  • 91.25 (n)
cow
(Bos Taurus)
Mammalia APOO 34 35
  • 89.9 (n)
mouse
(Mus musculus)
Mammalia Apoo 34 16 35
  • 86.53 (n)
Apoo-ps 35
  • 83 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Apoo 34
  • 85.19 (n)
oppossum
(Monodelphis domestica)
Mammalia APOO 35
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia APOO 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves APOO 35 34
  • 67.2 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia apoo 34
  • 59.89 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2586 34
zebrafish
(Danio rerio)
Actinopterygii apooa 34 35
  • 52.91 (n)
apoob 35
  • 30 (a)
OneToMany
Species where no ortholog for APOO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APOO Gene

ENSEMBL:
Gene Tree for APOO (if available)
TreeFam:
Gene Tree for APOO (if available)

Paralogs for APOO Gene

Paralogs for APOO Gene

(2) SIMAP similar genes for APOO Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with APOO: view

Variants for APOO Gene

Sequence variations from dbSNP and Humsavar for APOO Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000055829 -- 23,881,142(+) TGATC(C/T)CAGCT intron-variant
rs1000121138 -- 23,889,201(+) AAAGG(C/T)AGATT intron-variant
rs1000125879 -- 23,883,173(+) CACCC(C/T)TGGGC intron-variant
rs1000131447 -- 23,858,426(+) ATTCG(C/T)GTTCA intron-variant
rs1000187476 -- 23,889,930(+) TGCTG(A/G)GATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for APOO Gene

Variant ID Type Subtype PubMed ID
dgv2237e212 CNV gain 25503493
nsv1141055 CNV deletion 24896259
nsv6836 CNV insertion 18451855

Variation tolerance for APOO Gene

Residual Variation Intolerance Score: 73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.55; 44.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for APOO Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
APOO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOO Gene

Disorders for APOO Gene

Relevant External Links for APOO

Genetic Association Database (GAD)
APOO
Human Genome Epidemiology (HuGE) Navigator
APOO
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APOO

No disorders were found for APOO Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APOO Gene

Publications for APOO Gene

  1. The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions. (PMID: 25764979) Koob S. … Reichert A.S. (Biochim. Biophys. Acta 2015) 2 3 4 64
  2. Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits. (PMID: 25781180) Ott C. … Kozjak-Pavlovic V. (PLoS ONE 2015) 2 3 4 64
  3. ApoO, a novel apolipoprotein, is an original glycoprotein up- regulated by diabetes in human heart. (PMID: 16956892) Lamant M. … Rouet P. (J. Biol. Chem. 2006) 2 3 4 64
  4. QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology. (PMID: 25997101) Guarani V. … Harper J.W. (Elife 2015) 3 4 64
  5. Apolipoprotein O is mitochondrial and promotes lipotoxicity in heart. (PMID: 24743151) Turkieh A. … Smih F. (J. Clin. Invest. 2014) 3 4 64

Products for APOO Gene

Sources for APOO Gene

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