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APOO Gene

protein-coding   GIFtS: 50
GCID: GC0XM023851

Apolipoprotein O

(Previous name: family with sequence similarity 121B)
(Previous symbol: FAM121B)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Apolipoprotein O1 2
FAM121B1 2 3 5
Family With Sequence Similarity 121B1 2
Brain My0252
Protein FAM121B3
MYO255

External Ids:    HGNC: 287271   Entrez Gene: 791352   Ensembl: ENSG000001848317   OMIM: 3007535   UniProtKB: Q9BUR53   

Export aliases for APOO gene to outside databases

Previous GC identifers: GC0XM023763 GC0XM021597


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for APOO Gene:
This gene is a member of the apolipoprotein family. Members of this protein family are involved in the transport
and metabolism of lipids. The encoded protein associates with HDL, LDL and VLDL lipoproteins and is characterized
by chondroitin-sulfate glycosylation. This protein may be involved in preventing lipid accumulation in the
myocardium in obese and diabetic patients. Alternative splicing results in multiple transcript variants.
Pseudogenes of this gene are found on chromosomes 3, 4, 5, 12 and 16.(provided by RefSeq, Sep 2009)

GeneCards Summary for APOO Gene:
APOO (apolipoprotein O) is a protein-coding gene. An important paralog of this gene is APOOL.

UniProtKB/Swiss-Prot: APOO_HUMAN, Q9BUR5
Function: Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a
microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that
is subsequently transferred to HDL. May be involved in myocardium-protective mechanisms against lipid
accumulation

Gene Wiki entry for APOO (Apolipoprotein O) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_167197.2  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the APOO gene promoter:
         Egr-3   SRF   Sp1   SRF (504 AA)   IRF-1   Egr-2   HEN1   IRF-2   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAPOO promoter sequence
   Search Chromatin IP Primers for APOO

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat APOO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.11   Ensembl cytogenetic band:  Xp22.11   HGNC cytogenetic band: Xp22.11

APOO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOO gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM023851:  view genomic region     (about GC identifiers)

Start:
23,851,465 bp from pter      End:
23,926,057 bp from pter
Size:
74,593 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: APOO_HUMAN, Q9BUR5 (See protein sequence)
Recommended Name: Apolipoprotein O precursor  
Size: 198 amino acids; 22285 Da
Secondary accessions: B2R4K9 Q9H3J9
Alternative splicing: 2 isoforms:  Q9BUR5-1   Q9BUR5-2   

Explore the universe of human proteins at neXtProt for APOO: NX_Q9BUR5

Explore proteomics data for APOO at MOPED

Post-translational modifications: 

  • O-glycosylation; glycosaminoglycan of chondroitin-sulfate type1
  • Glycosylation2 at Ser162
  • Modification sites at PhosphoSitePlus

  • See APOO Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_077027.1  
    ENSEMBL proteins: 
     ENSP00000368528   ENSP00000402557   ENSP00000434341   ENSP00000368522  

    APOO Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for APOO

     
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    APOO Assay Products:

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    Search eBioscience for ELISAs for APOO 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    APOLIPO: Apolipoproteins

    1 InterPro protein domain:
     IPR019166 Apolipoprotein_O

    Graphical View of Domain Structure for InterPro Entry Q9BUR5

    ProtoNet protein and cluster: Q9BUR5

    UniProtKB/Swiss-Prot: APOO_HUMAN, Q9BUR5
    Similarity: Belongs to the apolipoprotein O family


    Find genes that share domains with APOO           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APOO_HUMAN, Q9BUR5
    Function: Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a
    microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that
    is subsequently transferred to HDL. May be involved in myocardium-protective mechanisms against lipid
    accumulation

    Phenotypes:
         2 GenomeRNAi human phenotypes for APOO:

     Increased G1 DNA content  Increased cell size 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for APOO
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for APOO

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for APOO
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for APOO

    miRNA
    Products:
        
    miRTarBase miRNAs that target APOO:
    hsa-mir-26b-5p (MIRT029755)

    Block miRNA regulation of human, mouse, rat APOO using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate APOO (see all 18):
    hsa-miR-181c hsa-miR-429 hsa-miR-4263 hsa-miR-20b* hsa-miR-3121-3p hsa-miR-200b hsa-miR-181b hsa-miR-181a
    SwitchGear 3'UTR luciferase reporter plasmidAPOO 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat APOO

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    GenScript: all cDNA clones in your preferred vector: APOO (NM_024122)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOO

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOO


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    APOO_HUMAN, Q9BUR5: Membrane; Single-pass membrane protein (Potential). Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    mitochondrion3
    cytosol2
    nucleus1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space ISS--
    GO:0005739mitochondrion IDA--
    GO:0016021integral component of membrane IEA--
    GO:0034361very-low-density lipoprotein particle IEA--
    GO:0034362low-density lipoprotein particle IEA--

    Find genes that share ontologies with APOO           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for APOO
    Interactions:

        Search GeneGlobe Interaction Network for APOO

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006869lipid transport IEA--

    Find genes that share ontologies with APOO           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for APOO



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for APOO gene: 
    NM_024122.4  

    Unigene Cluster for APOO:

    Apolipoprotein O
    Hs.495851  [show with all ESTs]
    Unigene Representative Sequence: NM_024122
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379226(uc004dax.3 uc004day.4) ENST00000476598 ENST00000439528
    ENST00000490078 ENST00000379220
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat APOO using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate APOO (see all 18):
    hsa-miR-181c hsa-miR-429 hsa-miR-4263 hsa-miR-20b* hsa-miR-3121-3p hsa-miR-200b hsa-miR-181b hsa-miR-181a
    SwitchGear 3'UTR luciferase reporter plasmidAPOO 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat APOO
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    OriGene ORF clones in mouse, rat for APOO
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: APOO (NM_024122)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for APOO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOO
    Primer
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    OriGene qPCR primer pairs and template standards for APOO
    OriGene qSTAR qPCR primer pairs in human, mouse for APOO
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat APOO
      QuantiTect SYBR Green Assays in human, mouse, rat APOO
      QuantiFast Probe-based Assays in human, mouse, rat APOO

    Additional mRNA sequence: 

    AF061264.1 AK311865.1 AY359114.1 BC002333.2 BC010102.2 BC016814.1 NR_026545.2 

    8 DOTS entries:

    DT.415328  DT.91856113  DT.100645432  DT.95274582  DT.95299082  DT.100057054  DT.121289560  DT.75102813 

    Selected AceView cDNA sequences (see all 120):

    CD672752 BE266369 BM702643 AI452533 BX099786 BC002333 AA906634 AA732719 
    AL552262 AA694531 AI199007 NM_024122 BC010102 BM695981 AY359114 CB105844 
    AA948373 AA176696 AI807655 CR608630 BM698725 AA689372 BF431747 CF243092 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    APOO expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGCTATTTA
    APOO Expression
    About this image


    APOO expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Thoracic Perivascular Adipose
    APOO Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    APOO Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.495851

    UniProtKB/Swiss-Prot: APOO_HUMAN, Q9BUR5
    Tissue specificity: Expressed in all tissues examined. Up-regulated in diabetic heart

        Custom PCR Arrays for APOO
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOO

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for APOO gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Apoo1 , 5 apolipoprotein O1, 5 86.53(n)1
    82.83(a)1
      X (41.56 cM)5
    683161  NM_026673.41  NP_080949.21 
     943671175 
    chicken
    (Gallus gallus)
    Aves APOO1 apolipoprotein O 67.2(n)
    58.29(a)
      418599  XM_004934655.1  XP_004934712.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.25862 Xenopus laevis transcribed sequence with weak similarity more 73.48(n)    BJ093852.1 
    zebrafish
    (Danio rerio)
    Actinopterygii apooa1 apolipoprotein O, a 52.91(n)
    48.15(a)
      641319  NM_001037115.1  NP_001032192.1 


    ENSEMBL Gene Tree for APOO (if available)
    TreeFam Gene Tree for APOO (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for APOO gene
    APOOL2  
    2 SIMAP similar genes for APOO using alignment to 4 protein entries:     APOO_HUMAN (see all proteins):
    DKFZp779P1227    APOOL

    Find genes that share paralogs with APOO           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for APOO (see all 6)
    PGOHUM00000239834 PGOHUM00000248903 PGOHUM00000238093 PGOHUM00000245560 PGOHUM00000235820


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for APOO (see all 1055)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1912572251,2
    --23765762(+) AGGAGA/GTGACA 2 -- ds50010--------
    rs1385614591,2
    --23765817(+) CTAATA/CATCGT 2 -- ds50010--------
    rs1491713811,2
    C--23765832(+) GAAACC/TGTATT 2 -- ds50010--------
    rs1830249861,2
    --23765865(+) GCTAGA/TTATTG 2 -- ds50010--------
    rs1858472001,2
    --23765882(+) CTCTCG/TGACTC 2 -- ds50010--------
    rs1909932711,2
    --23766153(+) TAAGGC/GTTGTA 2 -- nc-transcript-variantut310--------
    rs48521,2
    C,F,H--23766189(+) AGGTTA/GGTTTG 2 -- nc-transcript-variantut317Minor allele frequency- G:0.10MN NS NA WA 978
    rs1831772321,2
    --23766441(+) CAGGCA/GCGGTG 2 -- int10--------
    rs1889099931,2
    --23766480(+) GAAGCC/TGAGGC 2 -- int10--------
    rs1923411551,2
    --23766696(+) TGGGCA/GACAAG 2 -- int10--------

    HapMap Linkage Disequilibrium report for APOO (23851465 - 23926057 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for APOO:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6836CNV Insertion18451855

    Locus Specific Mutation Databases (LSDB): APOO

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing APOO
    DNA2.0 Custom Variant and Variant Library Synthesis for APOO

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300753    OMIM disorders: --


    Find genes that share disorders with APOO           About GenesLikeMe

    Genetic Association Database (GAD): APOO
    Human Genome Epidemiology (HuGE) Navigator: APOO (5 documents)

    Export disorders for APOO gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for APOO gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with APOO)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ApoO, a novel apolipoprotein, is an original glycoprotein up- regulated by diabetes in human heart. (PubMed id 16956892)1, 2, 3 Lamant M....Rouet P. (J. Biol. Chem. 2006)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1, 4 Chapuis J....Lambert J.C. (Mol. Psychiatry 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Plasma apolipoprotein O level increased in the patients with acute coronary syndrome. (PubMed id 22693255)1 Yu B.L....Zhao S.P. (J. Lipid Res. 2012)
    7. Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project. (PubMed id 20877300)1 Perroud N....McGuffin P. (Pharmacogenomics J. 2012)
    8. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (Stem Cells 2011)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79135 HGNC: 28727 AceView: MGC4825 Ensembl:ENSG00000184831 euGenes: HUgn79135
    ECgene: APOO H-InvDB: APOO

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for APOO Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for APOO gene:
    Search GeneIP for patents involving APOO

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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     Search Addgene for plasmids for APOO
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