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Aliases for APOO Gene

Aliases for APOO Gene

  • Apolipoprotein O 2 3
  • FAM121B 3 4 6
  • Family With Sequence Similarity 121B 2 3
  • Protein FAM121B 4
  • Brain My025 3
  • My025 3
  • MYO25 6

External Ids for APOO Gene

Previous HGNC Symbols for APOO Gene

  • FAM121B

Previous GeneCards Identifiers for APOO Gene

  • GC0XM023763
  • GC0XM021597

Summaries for APOO Gene

Entrez Gene Summary for APOO Gene

  • This gene is a member of the apolipoprotein family. Members of this protein family are involved in the transport and metabolism of lipids. The encoded protein associates with HDL, LDL and VLDL lipoproteins and is characterized by chondroitin-sulfate glycosylation. This protein may be involved in preventing lipid accumulation in the myocardium in obese and diabetic patients. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 4, 5, 12 and 16.[provided by RefSeq, Sep 2009]

GeneCards Summary for APOO Gene

APOO (Apolipoprotein O) is a Protein Coding gene. An important paralog of this gene is APOOL.

UniProtKB/Swiss-Prot for APOO Gene

  • Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. May be involved in myocardium-protective mechanisms against lipid accumulation.

Gene Wiki entry for APOO Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOO Gene

Genomics for APOO Gene

Regulatory Elements for APOO Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for APOO Gene

23,833,348 bp from pter
23,907,940 bp from pter
74,593 bases
Minus strand

Genomic View for APOO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APOO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOO Gene

Proteins for APOO Gene

  • Protein details for APOO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Apolipoprotein O
    Protein Accession:
    Secondary Accessions:
    • B2R4K9
    • Q9H3J9

    Protein attributes for APOO Gene

    198 amino acids
    Molecular mass:
    22285 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for APOO Gene


neXtProt entry for APOO Gene

Proteomics data for APOO Gene at MOPED

Post-translational modifications for APOO Gene

  • O-glycosylation; glycosaminoglycan of chondroitin-sulfate type
  • Glycosylation at Ser162
  • Modification sites at PhosphoSitePlus

Other Protein References for APOO Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for APOO Gene

Domains for APOO Gene

Gene Families for APOO Gene


Protein Domains for APOO Gene


Suggested Antigen Peptide Sequences for APOO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BUR5
  • Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.
genes like me logo Genes that share domains with APOO: view

Function for APOO Gene

Molecular function for APOO Gene

UniProtKB/Swiss-Prot Function:
Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. May be involved in myocardium-protective mechanisms against lipid accumulation.

Phenotypes for APOO Gene

GenomeRNAi human phenotypes for APOO:
genes like me logo Genes that share phenotypes with APOO: view

Animal Model Products

CRISPR Products

miRNA for APOO Gene

miRTarBase miRNAs that target APOO

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for APOO Gene

Localization for APOO Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOO Gene

Membrane; Single-pass membrane protein. Secreted.

Subcellular locations from

Jensen Localization Image for APOO Gene COMPARTMENTS Subcellular localization image for APOO gene
Compartment Confidence
extracellular 5
mitochondrion 3
cytosol 2
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for APOO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space ISS 22261194
GO:0005739 mitochondrion IDA 20833797
GO:0016021 integral component of membrane IEA --
GO:0034361 very-low-density lipoprotein particle IEA --
GO:0034362 low-density lipoprotein particle IEA --
genes like me logo Genes that share ontologies with APOO: view

Pathways for APOO Gene

SuperPathways for APOO Gene

No Data Available

Interacting Proteins for APOO Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000368528 for APOO Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for APOO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport IEA --
genes like me logo Genes that share ontologies with APOO: view

No data available for Pathways by source for APOO Gene

Transcripts for APOO Gene

Unigene Clusters for APOO Gene

Apolipoprotein O:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APOO

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for APOO Gene

No ASD Table

Relevant External Links for APOO Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for APOO Gene

mRNA expression in normal human tissues for APOO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for APOO Gene

This gene is overexpressed in Brain (10.2) and Heart (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for APOO Gene

SOURCE GeneReport for Unigene cluster for APOO Gene Hs.495851

mRNA Expression by UniProt/SwissProt for APOO Gene

Tissue specificity: Expressed in all tissues examined. Up-regulated in diabetic heart.
genes like me logo Genes that share expressions with APOO: view

Expression partners for APOO Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for APOO Gene

Orthologs for APOO Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOO Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia APOO 35
  • 89.9 (n)
  • 86.87 (a)
  • 85 (a)
(Canis familiaris)
Mammalia APOO 35
  • 91.25 (n)
  • 90.4 (a)
  • 74 (a)
(Mus musculus)
Mammalia Apoo 35
  • 86.53 (n)
  • 82.83 (a)
Apoo 16
Apoo 36
  • 76 (a)
Apoo-ps 36
  • 83 (a)
(Pan troglodytes)
Mammalia APOO 35
  • 99.49 (n)
  • 99.49 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Apoo 35
  • 85.19 (n)
  • 80.3 (a)
(Monodelphis domestica)
Mammalia APOO 36
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia APOO 36
  • 55 (a)
(Gallus gallus)
Aves APOO 35
  • 67.2 (n)
  • 58.29 (a)
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia apoo 35
  • 59.89 (n)
  • 49.73 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2586 35
(Danio rerio)
Actinopterygii apooa 35
  • 52.91 (n)
  • 48.15 (a)
apooa 36
  • 42 (a)
apoob 36
  • 30 (a)
Species with no ortholog for APOO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APOO Gene

Gene Tree for APOO (if available)
Gene Tree for APOO (if available)

Paralogs for APOO Gene

Paralogs for APOO Gene

Selected SIMAP similar genes for APOO Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with APOO: view

Variants for APOO Gene

Sequence variations from dbSNP and Humsavar for APOO Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs4852 -- 23,833,456(+) AGGTT(A/G)GTTTG utr-variant-3-prime, nc-transcript-variant
rs8680 -- 23,840,335(+) GCATG(A/G)AGTTT utr-variant-3-prime, nc-transcript-variant
rs2106423 -- 23,890,722(-) actca(A/G)aacac intron-variant
rs2106424 -- 23,890,693(-) gggca(A/G)aatca intron-variant
rs2106425 -- 23,890,607(-) aagca(A/G)aatgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for APOO Gene

Variant ID Type Subtype PubMed ID
nsv6836 CNV Insertion 18451855

Relevant External Links for APOO Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOO Gene

Disorders for APOO Gene

Relevant External Links for APOO

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for APOO Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for APOO Gene

Publications for APOO Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. ApoO, a novel apolipoprotein, is an original glycoprotein up- regulated by diabetes in human heart. (PMID: 16956892) Lamant M. … Rouet P. (J. Biol. Chem. 2006) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J. … Lambert J.C. (Mol. Psychiatry 2009) 3 48
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for APOO Gene

Sources for APOO Gene

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