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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

APOM Gene

protein-coding   GIFtS: 59
GCID: GC06P031620

apolipoprotein M
 Explore 18 diseases affiliated with
APOM via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for APOM    

Aliases
for APOM gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Apolipoprotein M1 2     Alternative Name: G3a, NG202
NG201 2 3     Apo-M3
G3a1 2     NG20-Like Protein2
ApoM1 3     Apo-M3
Protein G3a2 3     G3A3
HSPC3362     

External Ids:    HGNC: 139161   Entrez Gene: 559372   Ensembl: ENSG000002044447   OMIM: 6069075   UniProtKB: O954453   

Export aliases for APOM gene to outside databases

Previous GC identifers: GC06P031687 GC06P031390 GC06P031727 GC06P031731 GC06P031410


Summaries
for APOM gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for APOM:
The protein encoded by this gene is an apolipoprotein and member of the lipocalin protein family. It is found
associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich
lipoproteins. The encoded protein is secreted through the plasma membrane but remains membrane-bound, where it is
involved in lipid transport. Alternate splicing results in both coding and non-coding variants of this gene. (provided
by RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: APOM_HUMAN, O95445
Function: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and
stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid

Gene Wiki entry for APOM


Genomic Views
for APOM gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  NT_113891.2  NT_167245.1  NT_167246.1  NT_167247.1  NT_167248.1  
NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the APOM gene promoter:
         COUP-TF1   PPAR-gamma1   STAT1   COUP-TF   COUP   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: APOM promoter sequence
   Search SABiosciences Chromatin IP Primers for APOM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.33   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21

APOM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOM gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P031620:  view genomic region     (about GC identifiers)

Start:
 31,620,193 bp from pter      End:
 31,625,987 bp from pter
Size:
 5,795 bases      Orientation:
 plus strand

6 alternative locations:
Chr6+,ALT_REF_LOCI_2 31,607,608-31,652,589      Chr6+,ALT_REF_LOCI_4 31,586,219-31,588,535      Chr6+,ALT_REF_LOCI_3 31,602,375-31,619,207     
Chr6+,ALT_REF_LOCI_6 31,610,434-31,651,808      Chr6+,ALT_REF_LOCI_5 31,614,774-31,617,090      Chr6+,ALT_REF_LOCI_7 31,543,934-31,546,250     

Proteins
for APOM gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: APOM_HUMAN, O95445 (See protein sequence)
Recommended Name: Apolipoprotein M  
Size: 188 amino acids; 21253 Da
Subcellular location: Secreted. Note=Present in high density lipoprotein (HDL) and to a lesser extent in
triglyceride-rich lipoproteins (TGRLP) and low density lipoproteins (LDL)
3 PDB 3D structures from and Proteopedia for APOM:
2WEW (3D)        2WEX (3D)        2YG2 (3D)    
Secondary accessions: B0UX98 Q5SRP4 Q9P046 Q9UMP6
Alternative splicing: 2 isoforms:  O95445-1   O95445-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for APOM: NX_O95445

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95445

    • APOM Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243098.1  NP_061974.2  

    ENSEMBL proteins: 
     ENSP00000365083   ENSP00000365085   ENSP00000365081  

    Human Recombinant Protein Products: 
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    Novus Biologicals APOM Proteins
    Novus Biologicals APOM Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for APOM
    Uscn Proteins for APOM

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space ----
    GO:0005887integral to plasma membrane TAS10531326
    GO:0034361very-low-density lipoprotein particle IDA17154273
    GO:0034362low-density lipoprotein particle IDA16682745


    APOM for ontologies           About GeneDecksing



    APOM Antibody Products: 
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    Uscn ELISAs and CLIAs for APOM

    Protein Domains /
    Families
    for APOM gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    APOM for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR022734 ApoM
     IPR011038 Calycin-like

    Graphical View of Domain Structure for InterPro Entry O95445

    ProtoNet protein and cluster: O95445

    UniProtKB/Swiss-Prot: APOM_HUMAN, O95445
    Similarity: Belongs to the calycin superfamily. Lipocalin family. Highly divergent


    Function
    for APOM gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: APOM_HUMAN, O95445
    Function: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and
    stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid

    miRNA
    Products:            		 OriGene 3'-UTR Clone: APOM
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APOM
    1 QIAGEN miScript miRNA Assays for microRNA that regulate APOM:
    hsa-miR-766
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APOM (see all 7)
    OriGene shRNA RFP: APOM
    OriGene siRNA: APOM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APOM

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for APOM

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APOM (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APOM
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    GenScript: all cDNA clones in your preferred vector: APOM (NM_019101)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOM 

    Cell Line
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    Search LifeMap BioReagents cell lines for APOM

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOM

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005319lipid transporter activity IDA16682745
    GO:0005543phospholipid binding IDA--
    GO:0016209antioxidant activity IDA--


    APOM for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for APOM:
     Decreased Hepatitis C virus re 

    Animal Models:
         Mouse knock-outs for APOM: Apomtm1Stf Apomtm1Cchr
         1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Apom):
     homeostasis/metabolism 

    APOM for phenotypes           About GeneDecksing


    Pathways & Interactions
    for APOM gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ca, cAMP and Lipid Signaling
    		Ca, cAMP and Lipid Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for APOM
        Ca, cAMP and Lipid Signaling



    APOM for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for APOM

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for APOM (O954452, 3 ENSP000003650814) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FAM203AQ9BTY72, 3MINT-65339 I2D: score=4 
    KLF6Q996122, 3, ENSP000004199234MINT-64538 I2D: score=5 STRING: ENSP00000419923
    --Q96BK83I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009749response to glucose stimulus IEA--
    GO:0033344cholesterol efflux IMP15793583
    GO:0034375high-density lipoprotein particle remodeling IMP18006500
    GO:0034380high-density lipoprotein particle assembly ISS15793583
    GO:0034384high-density lipoprotein particle clearance ISS15793583


    APOM for ontologies           About GeneDecksing



    Drugs & Compounds
    for APOM gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    APOM for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for APOM

    1 DrugBank Compound for APOM    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    MYRISTIC ACID-- --carrier--10592235

    5 Novoseek chemical compound relationships for APOM gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholesterol 57.9 33 15542348 (5), 17526892 (3), 18490703 (3), 16682745 (2) (see all 14)
    lipid 32 3 15542348 (1), 19153651 (1)
    phospholipid 17.8 2 10531326 (1), 17101555 (1)
    acth 14.7 2 15222631 (1), 11514556 (1)
    glucose 7.6 1 15542348 (1)

    Search CenterWatch for drugs/clinical trials and news about APOM 

    Transcripts
    for APOM gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for APOM gene (2 alternative transcripts): 
    NM_001256169.1  NM_019101.2  

    Unigene Cluster for APOM:

    Apolipoprotein M
    Hs.534468  [show with all ESTs]
    Unigene Representative Sequence: BG567934
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375918 ENST00000375920(uc003nvk.3) ENST00000375916(uc003nvl.3)


    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APOM
    1 QIAGEN miScript miRNA Assays for microRNA that regulate APOM:
    hsa-miR-766
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APOM (see all 7)
    OriGene shRNA RFP: APOM
    OriGene siRNA: APOM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APOM
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APOM
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: APOM (NM_019101)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for APOM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOM 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat APOM
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APOM
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APOM

    Additional cDNA sequence: 

    AF118393.3 AF161454.1 AJ245434.1 BC020683.1 NR_045828.1 

    12 DOTS entries:

    DT.417144  DT.417143  DT.121312769  DT.95264837  DT.99945542  DT.91768627  DT.92458335  DT.121312759 
    DT.121312766  DT.452848  DT.92458314  DT.454198 

    24/132 AceView cDNA sequences (see all 132):

    CB054015 AV646167 AV646373 AV660137 AV681809 BX105475 AV652705 AF161454 
    AV655684 AV651991 AV682741 BX956704 AI825658 AV651963 AV646060 AI937498 
    AV651957 AA243845 AI338771 AI245278 AI858956 NM_019101 AA331300 BX100487 

    GeneLoc Exon Structure


    Expression
    for APOM gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    APOM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGAATGAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    APOM expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    AdiposeBody Subcutaneous White AdiposeAdipose
    HeartAtrioventricular CanalHeart
    KidneyEpithelial TubuleKidney
    KidneyMetanephrosKidney
    LiverLiver LobuleLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Primitive gut tube-like cells (A scalable, suspensi...)
    Beating cell clusters (Spontaneous differen...)

    See APOM Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for APOM

    SOURCE GeneReport for Unigene cluster: Hs.534468

    UniProtKB/Swiss-Prot: APOM_HUMAN, O95445
    Tissue specificity: Plasma protein. Expressed in liver and kidney

        SABiosciences Custom PCR Arrays for APOM
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOM

    Orthologs
    for APOM gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for APOM gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Apom1 , 5 apolipoprotein M1, 5 84.49(n)1
    81.82(a)1    		   17 (18.59 cM)5
    559381  NM_018816.11  NP_061286.11 
     351289975 
    lizard
    (Anolis carolinensis)    		 Reptilia APOM6
    		 --
    		 45(a)
    		 1 ↔ 1
    		 2(194027089-194032976)


    ENSEMBL Gene Tree for APOM (if available)
    TreeFam Gene Tree for APOM (if available) 

    Paralogs
    for APOM gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for APOM gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/64 NCBI SNPs in APOM are shown (see all 64)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs558808111,2
    		C--31622531(+) TTATTC/TGAGAA 3 -- us2k1 int10--------
    rs1142886011,2
    		F,--31622537(+) GAGAAC/ATTATT 3 -- int1 us2k11Minor allele frequency- A:0.03WA 118
    rs8052971,2
    		C,F,H,--31622606(-) ggtaaG/Ttccaa 3 -- us2k1 int129Minor allele frequency- T:0.25NS EA NA 3334
    rs773225551,2
    		C,--31622630(+) TGCTAA/CGGGCT 3 -- us2k1 int10--------
    rs1458771301,2
    		--31622728(+) TGGTGG/TTTTGT 3 -- int1 us2k10--------
    rs1850616871,2
    		--31622736(+) TGTTTC/GTTTGG 3 -- int1 us2k10--------
    rs94049411,2
    		C,F,--31622816(+) CAGGCT/CCAAGC 3 -- us2k1 int12Minor allele frequency- C:0.11NA EA 240
    rs8052961,2
    		C,F,H,--31622893(-) aaaaaA/Gtacaa 3 -- int1 us2k12Minor allele frequency- G:0.12WA EA 238
    rs1508630401,2
    		C,--31622949(+) CTGGG-/CTCAAG 3 -- us2k1 int10--------
    rs766113451,2
    		C,--31623074(+) ACAGCA/CAGATT 3 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for APOM (31620193 - 31625987 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for APOM: --
    Human Gene Mutation Database (HGMD): APOM

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing APOM
    DNA2.0 Custom Variant and Variant Library Synthesis for APOM

    Disorders / Diseases
    for APOM gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    APOM for disorders           About GeneDecksing

    OMIM gene information: 606907    OMIM disorders: --

    18 diseases for APOM:    About MalaCards
    critical limb ischemia    abdominal aortic aneurysm    type 2 diabetes mellitus    aortic aneurysm
    coronary heart disease    diabetes mellitus    cerebral infarction    rheumatoid arthritis
    ischemia    liver disease    atherosclerosis    hepatocellular carcinoma
    alzheimer's disease    cerebritis    arthritis    obesity
    cholesterol    carcinoma

    1 Novoseek disease relationship for APOM gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atherosclerosis 22.8 8 19909825 (3), 17218068 (1), 18006500 (1), 17101555 (1) (see all 5)

    Genetic Association Database (GAD): APOM
    Human Genome Epidemiology (HuGE) Navigator: APOM (15 documents)

    Export disorders for APOM gene to outside databases

    Publications
    for APOM gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for APOM gene, integrated from 9 sources (see all 90):
    (articles sorted by number of sources associating them with APOM)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human apolipoprotein (apoM). (PubMed id 10531326)1, 2, 3, 9 Xu N. and Dahlbaeck B. (1999)
    2. Proposed lipocalin fold for apolipoprotein M based on bioinformatics and site-directed mutagenesis. (PubMed id 11418126)1, 2, 3, 9 Duan J....Villoutreix B.O. (2001)
    3. Hydrophobic ligand binding properties of the human lipocalin apolipoprotein M. (PubMed id 17525477)1, 2, 9 Ahnstrom J....Dahlback B. (2007)
    4. Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population. (PubMed id 15172102)1, 4, 9 Kabbara A....Lambert J.C. (2004)
    5. Serendipitous fatty acid binding reveals the structur al determinants for ligand recognition in apolipoprotein M. (PubMed id 19733574)1, 2, 9 Sevvana M....Muller Y.A. (2009)
    6. Apolipoprotein M associates to lipoproteins through its retained signal peptide. (PubMed id 18279674)1, 2, 9 Axler O....Dahlback B. (2008)
    7. The signal peptide anchors apolipoprotein M in plasma lipoproteins and prevents rapid clearance of apolipoprotein M from plasma. (PubMed id 18460466)1, 2, 9 Christoffersen C....Nielsen L.B. (2008)
    8. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    9. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1, 2 Brandenberger R.... Stanton L.W. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for APOM gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing APOM gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55937 HGNC: 13916 AceView: APOM Ensembl:ENSG00000204444 euGenes: HUgn55937
    ECgene: APOM H-InvDB: APOM

    Other Databases showing APOM gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing APOM gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for APOM Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for APOM gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for APOM gene:
    Search GeneIP for patents involving APOM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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