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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

APOM Gene

protein-coding   GIFtS: 60
GCID: GC06P031620

Apolipoprotein M

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Apolipoprotein M1 2     apo-M2
Protein G3a2 3     NG20-Like Protein2
NG202 3     Apo-M3
G3a2     ApoM3
HSPC3362     G3A3
Alternative Name: G3a, NG202     

External Ids:    HGNC: 139161   Entrez Gene: 559372   Ensembl: ENSG000002044447   OMIM: 6069075   UniProtKB: O954453   

Export aliases for APOM gene to outside databases

Previous GC identifers: GC06P031687 GC06P031390 GC06P031727 GC06P031731 GC06P031410


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for APOM Gene:
The protein encoded by this gene is an apolipoprotein and member of the lipocalin protein family. It is found
associated with high density lipoproteins and to a lesser extent with low density lipoproteins and
triglyceride-rich lipoproteins. The encoded protein is secreted through the plasma membrane but remains
membrane-bound, where it is involved in lipid transport. Alternate splicing results in both coding and non-coding
variants of this gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for APOM Gene: 
APOM (apolipoprotein M) is a protein-coding gene. Diseases associated with APOM include critical limb ischemia, and abdominal aortic aneurysm. GO annotations related to this gene include phospholipid binding and lipid transporter activity.

UniProtKB/Swiss-Prot: APOM_HUMAN, O95445
Function: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and
stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid

Gene Wiki entry for APOM Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  NT_113891.2  NT_167245.1  NT_167246.1  NT_167247.1  NT_167248.1  
NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the APOM gene promoter:
         COUP-TF1   PPAR-gamma1   STAT1   COUP-TF   COUP   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAPOM promoter sequence
   Search SABiosciences Chromatin IP Primers for APOM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.33   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21

APOM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOM gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P031620:  view genomic region     (about GC identifiers)

Start:
31,620,193 bp from pter      End:
31,625,987 bp from pter
Size:
5,795 bases      Orientation:
plus strand

6 alternative locations:
Chr6+,NT_167246 2,966,560-2,968,876      Chr6+,NT_167248 2,917,308-2,919,624      Chr6+,NT_167247 3,003,351-3,005,667     
Chr6+,NT_113891.2 3,133,289-3,135,605      Chr6+,NT_167249 2,954,469-2,956,785      Chr6+,NT_167245 2,909,250-2,911,566     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: APOM_HUMAN, O95445 (See protein sequence)
Recommended Name: Apolipoprotein M  
Size: 188 amino acids; 21253 Da
Subcellular location: Secreted. Note=Present in high density lipoprotein (HDL) and to a lesser extent in
triglyceride-rich lipoproteins (TGRLP) and low density lipoproteins (LDL)
3 PDB 3D structures from and Proteopedia for APOM:
2WEW (3D)        2WEX (3D)        2YG2 (3D)    
Secondary accessions: B0UX98 Q5SRP4 Q9P046 Q9UMP6
Alternative splicing: 2 isoforms:  O95445-1   O95445-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for APOM: NX_O95445

Explore proteomics data for APOM at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95445

  • APOM Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    APOM Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001243098.1  NP_061974.2  

    ENSEMBL proteins: 
     ENSP00000365083   ENSP00000365085   ENSP00000365081  

    Human Recombinant Protein Products for APOM: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for APOM (Apolipoprotein M/ApoM)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for APOM
    OriGene Protein Over-expression Lysate for APOM
    OriGene MassSpec for APOM 
    OriGene Custom Protein Services for APOM
    GenScript Custom Purified and Recombinant Proteins Services for APOM
    Novus Biologicals APOM Proteins
    Novus Biologicals APOM Lysates
    Sino Biological Recombinant Protein for APOM
    Sino Biological Cell Lysate for APOM 
    ProSpec Recombinant Protein for APOM
    Cloud-Clone Corp. Proteins for APOM 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space ----
    GO:0005887integral to plasma membrane TAS10531326
    GO:0034361very-low-density lipoprotein particle IDA17154273
    GO:0034362low-density lipoprotein particle IDA16682745

    APOM for ontologies           About GeneDecksing



    APOM Antibody Products: 
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    GenScript Superior Antibodies for APOM
    Novus Biologicals APOM Antibodies
    Abcam antibodies for APOM
    Cloud-Clone Corp. Antibodies for APOM 
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    LSBio Antibodies in human, mouse, rat for APOM 

    Assay Products for APOM: 
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    Cloud-Clone Corp. ELISAs for APOM 
    Cloud-Clone Corp. CLIAs for APOM


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    APOLIPO: Apolipoproteins

    2 InterPro protein domains:
     IPR022734 ApoM
     IPR011038 Calycin-like

    Graphical View of Domain Structure for InterPro Entry O95445

    ProtoNet protein and cluster: O95445

    UniProtKB/Swiss-Prot: APOM_HUMAN, O95445
    Similarity: Belongs to the calycin superfamily. Lipocalin family. Highly divergent


    APOM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APOM_HUMAN, O95445
    Function: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and
    stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005319lipid transporter activity IDA16682745
    GO:0005543phospholipid binding IDA--
    GO:0016209antioxidant activity IDA--
         
    APOM for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for APOM:
     Decreased Hepatitis C virus re 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Apom):
     homeostasis/metabolism 

    APOM for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for APOM: Apomtm1Stf Apomtm1Cchr

       inGenious Targeting Laboratory - Custom generated mouse model solutions for APOM 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for APOM

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for APOM 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for APOM 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APOM
    1 QIAGEN miScript miRNA Assays for microRNA that regulate APOM:
    hsa-miR-766
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for APOM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APOM

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of APOM

    Clone
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for APOM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOM
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                         Customized lentivirus expression plasmids for stable overexpression of APOM 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOM


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for APOM About                                                                                                See pathways by source

    SuperPathContained pathways About
    1"Ca, cAMP and Lipid Signaling"
    "Ca, cAMP and Lipid Signaling"

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for APOM
        Ca, cAMP and Lipid Signaling




    APOM for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for APOM

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for APOM (O954452, 3 ENSP000003650814) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FAM203AQ9BTY72, 3MINT-65339 I2D: score=4 
    KLF6Q996122, 3, ENSP000004199234MINT-64538 I2D: score=5 STRING: ENSP00000419923
    --Q96BK83I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009749response to glucose stimulus IEA--
    GO:0033344cholesterol efflux IMP15793583
    GO:0034375high-density lipoprotein particle remodeling IMP18006500
    GO:0034380high-density lipoprotein particle assembly ISS15793583
    GO:0034384high-density lipoprotein particle clearance ISS15793583

    APOM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    APOM for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for APOM

    1 DrugBank Compound for APOM    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    MYRISTIC ACID-- --carrier--10592235

    5 Novoseek inferred chemical compound relationships for APOM gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholesterol 57.9 33 15542348 (5), 17526892 (3), 18490703 (3), 16682745 (2) (see all 14)
    lipid 32 3 15542348 (1), 19153651 (1)
    phospholipid 17.8 2 10531326 (1), 17101555 (1)
    acth 14.7 2 15222631 (1), 11514556 (1)
    glucose 7.6 1 15542348 (1)

    Search CenterWatch for drugs/clinical trials and news about APOM

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for APOM gene (2 alternative transcripts): 
    NM_001256169.1  NM_019101.2  

    Unigene Cluster for APOM:

    Apolipoprotein M
    Hs.534468  [show with all ESTs]
    Unigene Representative Sequence: BG567934
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375918 ENST00000375920(uc003nvk.3) ENST00000375916(uc003nvl.3)


    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APOM
    1 QIAGEN miScript miRNA Assays for microRNA that regulate APOM:
    hsa-miR-766
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for APOM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APOM
    Clone
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    OriGene ORF clones in mouse, rat for APOM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: APOM (NM_019101)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for APOM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOM
    Sirion Biotech Customized lentivirus for stable overexpression of APOM 
                         Customized lentivirus expression plasmids for stable overexpression of APOM 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for APOM
    OriGene qSTAR qPCR primer pairs in human, mouse for APOM
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat APOM
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APOM
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APOM

    Additional mRNA sequence: 

    AF118393.3 AF161454.1 AJ245434.1 BC020683.1 NR_045828.1 

    12 DOTS entries:

    DT.417144  DT.417143  DT.121312769  DT.95264837  DT.99945542  DT.91768627  DT.92458335  DT.121312759 
    DT.121312766  DT.452848  DT.92458314  DT.454198 

    24/132 AceView cDNA sequences (see all 132):

    AV646167 AA815182 AA383229 AV651963 AI937498 BX105475 AV646060 BX956704 
    AV660296 AV651957 AI338771 AV651609 BX100487 AV682741 AV655684 NM_019101 
    AA331300 AV681809 AA243845 AF161454 AI245278 AV660137 AV646373 AV651991 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    APOM expression in normal human tissues (normalized intensities)      APOM embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAATGAGA
    APOM Expression
    About this image


    APOM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Metanephros
             visceral organ/metanephros/renal cortex   
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Mesothelial Cells Hepatic Mesenchyme
             Liver Lobule
     
     Heart (Cardiovascular System)
             Primitive Heart Tube Cells Primitive Heart Tube
     
     Gut Tube (Gastrointestinal Tract)
             Primitive gut tube-like cells ( A scalable, suspension protocol for derivation of...
     
     Uterus (Reproductive System)
             cervix   

    See APOM Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for APOM

    SOURCE GeneReport for Unigene cluster: Hs.534468

    UniProtKB/Swiss-Prot: APOM_HUMAN, O95445
    Tissue specificity: Plasma protein. Expressed in liver and kidney

        SABiosciences Custom PCR Arrays for APOM
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for APOM gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Apom1 , 5 apolipoprotein M1, 5 84.49(n)1
    81.82(a)1
      17 (18.59 cM)5
    559381  NM_018816.11  NP_061286.11 
     351289975 
    lizard
    (Anolis carolinensis)
    Reptilia APOM6
    apolipoprotein M
    44(a)
    1 ↔ 1
    2(194026272-194035470)
    zebrafish
    (Danio rerio)
    Actinopterygii APOM6
    apolipoprotein M
    19(a)
    1 ↔ 1
    2(42329859-42335679)


    ENSEMBL Gene Tree for APOM (if available)
    TreeFam Gene Tree for APOM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/68 SNPs in APOM are shown (see all 68)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs558808111,2
    C--31622531(+) TTATTC/TGAGAA 3 -- us2k1 int10--------
    rs1142886011,2
    C,F--31622537(+) GAGAAC/ATTATT 3 -- us2k1 int11Minor allele frequency- A:0.03WA 118
    rs8052971,2
    C,F,H--31622606(-) ggtaaG/Ttccaa 3 -- us2k1 int129Minor allele frequency- T:0.25NS EA NA 3334
    rs773225551,2
    C--31622630(+) TGCTAA/CGGGCT 3 -- us2k1 int10--------
    rs1458771301,2
    --31622728(+) TGGTGG/TTTTGT 3 -- us2k1 int10--------
    rs1850616871,2
    --31622736(+) TGTTTC/GTTTGG 3 -- us2k1 int10--------
    rs94049411,2
    C,F--31622816(+) CAGGCT/CCAAGC 3 -- us2k1 int12Minor allele frequency- C:0.11NA EA 240
    rs8052961,2
    C,F,H--31622893(-) aaaaaA/Gtacaa 3 -- us2k1 int12Minor allele frequency- G:0.12WA EA 238
    rs1508630401,2
    C--31622949(+) CTGGG-/CTCAAG 3 -- us2k1 int10--------
    rs766113451,2
    C--31623074(+) ACAGCA/CAGATT 3 -- us2k1 int10--------

    HapMap Linkage Disequilibrium report for APOM (31620193 - 31625987 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for APOM:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830627CNV Loss17160897
    dgv6581n71CNV Loss21882294
    nsv462871CNV Loss19166990
    nsv884418CNV Gain21882294


    Human Gene Mutation Database (HGMD): APOM
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing APOM
    DNA2.0 Custom Variant and Variant Library Synthesis for APOM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606907    OMIM disorders: --

    18 diseases for APOM:    About MalaCards
    critical limb ischemia    abdominal aortic aneurysm    cerebral infarction    aortic aneurysm
    atherosclerosis    coronary heart disease    ischemia    cerebritis
    diabetes mellitus    liver disease    type 1 diabetes    obesity
    rheumatoid arthritis    arthritis    alzheimer's disease    hepatocellular carcinoma
    adenocarcinoma    lung cancer


    APOM for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for APOM gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atherosclerosis 22.8 8 19909825 (3), 17218068 (1), 18006500 (1), 17101555 (1) (see all 5)

    Genetic Association Database (GAD): APOM
    Human Genome Epidemiology (HuGE) Navigator: APOM (15 documents)

    Export disorders for APOM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for APOM gene, integrated from 9 sources (see all 95):
    (articles sorted by number of sources associating them with APOM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human apolipoprotein (apoM). (PubMed id 10531326)1, 2, 3, 9 Xu N. and Dahlbaeck B. (1999)
    2. Proposed lipocalin fold for apolipoprotein M based on bioinformatics and site-directed mutagenesis. (PubMed id 11418126)1, 2, 3, 9 Duan J....Villoutreix B.O. (2001)
    3. Evaluation of Apolipoprotein M Serum Concentration as a Biomarker of HNF-1alpha MODY. (PubMed id 18338076)1, 4, 9 Skupien J....Malecki M.T. (2007)
    4. Hydrophobic ligand binding properties of the human lipocalin apolipoprotein M. (PubMed id 17525477)1, 2, 9 Ahnstrom J....Dahlback B. (2007)
    5. Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population. (PubMed id 15172102)1, 4, 9 Kabbara A....Lambert J.C. (2004)
    6. Serendipitous fatty acid binding reveals the structur al determinants for ligand recognition in apolipoprotein M. (PubMed id 19733574)1, 2, 9 Sevvana M....Muller Y.A. (2009)
    7. Apolipoprotein M promoter polymorphisms alter promoter activity and confer the susceptibility to the development of type 1 diabetes. (PubMed id 19007767)1, 4, 9 Wu X....Liu Y. (2009)
    8. Apolipoprotein M associates to lipoproteins through its retained signal peptide. (PubMed id 18279674)1, 2, 9 Axler O....Dahlback B. (2008)
    9. The signal peptide anchors apolipoprotein M in plasma lipoproteins and prevents rapid clearance of apolipoprotein M from plasma. (PubMed id 18460466)1, 2, 9 Christoffersen C....Nielsen L.B. (2008)
    10. A genetic variant of apolipoprotein M increases susceptibility to coronary artery disease in a Chinese population. (PubMed id 17973931)1, 4, 9 Xu W.W....Fan L.M. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55937 HGNC: 13916 AceView: APOM Ensembl:ENSG00000204444 euGenes: HUgn55937
    ECgene: APOM H-InvDB: APOM

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for APOM Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for APOM gene:
    Search GeneIP for patents involving APOM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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