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APOM Gene

protein-coding   GIFtS: 51

GC06P031731
apolipoprotein M
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
Apo-M 3
ApoM 1, 3
G3A 3
G3a 1, 2
HSPC336 2
MGC22400 2
NG20 1, 2, 3
OTTHUMP00000029364 2
Descriptions
NG20-like protein 2
Protein G3a 3
alternative name: G3a, NG20 2
apolipoprotein M 2
External Ids
HGNC: 139161
Entrez Gene: 559372
UniProtKB: O954453
Search outside databases for aliases for APOM gene

Previous GC identifers: GC06P031687 GC06P031390 GC06P031727

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for APOM:
The protein encoded by this gene is an apolipoprotein and member of the lipocalin protein family.
It is found associated with high density lipoproteins and to a lesser extent with low density
lipoproteins and triglyceride-rich lipoproteins. The encoded protein is secreted through the
plasma membrane but remains membrane-bound, where it is involved in lipid transport. Two
transcript variants encoding two different isoforms have been found for this gene, but only one of
them has been fully characterized. [provided by RefSeq]

UniProtKB/Swiss-Prot: APOM_HUMAN, O95445
Function: Probably involved in lipid transport

Gene Wiki entry for APOM

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the APOM gene  

Entrez Gene cytogenetic band: 6p21.33   HGNC cytogenetic band: 6p21

APOM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P031731:     (about GC identifiers)

Start:
31,731,650 bp from pter
End:
31,733,966 bp from pter
Size:
2,317 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000006.10  NT_007592.14  NT_113891.1  NT_113894.1  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: APOM_HUMAN, O95445 (See protein sequence)
Recommended Name: Apolipoprotein M  
Size: 188 amino acids; 21253 Da
Subcellular location: Secreted. Note=Present in high density lipoprotein (HDL) and to a lesser
extent in triglyceride-rich lipoproteins (TGRLP) and low density lipoproteins (LDL)
Secondary accessions: Q9P046 Q9UMP6

REFSEQ proteins: NP_061974.2  
Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (Apolipoprotein M)
Human Recombinant Proteins from Abnova (APOM)
              OriGene Purified Recombinant Human Protein: APOM 

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region IEA--
GO:0005829 cytosol IEA--
GO:0005887 integral to plasma membrane TAS10531326
GO:0034364 high-density lipoprotein particle IEA--
GO:0043234 protein complex IEA--
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Antibodies for APOM: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for APOM
R&D Systems Antibodies for APOM (Apolipoprotein M/ApoM)
Antibodies from Abcam (Apolipoprotein M), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (APOM)
Novus Biologicals Antibodies for APOM

Assays for APOM: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: O95445

UniProtKB/Swiss-Prot: APOM_HUMAN, O95445
Similarity: Belongs to the calycin superfamily. Lipocalin family. Highly divergent

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (APOM)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (APOM)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_019101

              Applied Biosystems Silencer® siRNAs for APOM

              Sigma-Aldrich siRNA for APOM  
                     Sigma-Aldrich shRNA for APOM  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for APOM
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_019101
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_019101
                                 untagged cDNA clone in CMV expression vector: NM_019101 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_019101

UniProtKB/Swiss-Prot: APOM_HUMAN, O95445
Function: Probably involved in lipid transport

1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Apom):

homeostasis/metabolism

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005319 lipid transporter activity TAS10531326
GO:0005515 protein binding IEA--
GO:0051059 NF-kappaB binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


 Gene Network CentralTM Interacting Genes and Proteins Network for  APOM 


2 Interacting proteins for APOM (O954452) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
C8orf30AQ9BTY72MINT-65339
KLF6Q996122MINT-64538
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5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0006091 generation of precursor metabolites and energy TAS10531326
GO:0006643 membrane lipid metabolic process TAS10531326
GO:0006869 lipid transport IEA--
GO:0006952 defense response IEA--
GO:0006986 response to unfolded protein IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for APOM
5 Novoseek chemical compound relationships for APOM gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
cholesterol 55.64 32 15542348 (5), 17526892 (3), 18490703 (3), 16682745 (2) (see all 13)
lipid 23.70 3 15542348 (1), 19153651 (1)
acth 18.27 2 15222631 (1), 11514556 (1)
phospholipid 8.70 2 10531326 (1), 17101555 (1)
glucose 6.16 1 15542348 (1)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (APOM)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (APOM)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_019101

              Sigma-Aldrich siRNA for APOM  
                     Sigma-Aldrich shRNA for APOM  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_019101  

REFSEQ mRNAs for APOM gene: 

NM_019101.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_019101  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_019101
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_019101
                                 untagged cDNA clone in CMV expression vector: NM_019101 

Additional cDNA sequence: 

AF118393.3 AF161454.1 AJ245434.1 BC020683.1 

11 DOTS entries:

DT.417144  DT.417143  DT.121312769  DT.95264837  DT.99945542  DT.91768627  DT.121312759  DT.92458335 
DT.121312766  DT.452848  DT.92458314 

24/132 AceView cDNA sequences (see all 132 ):

AV651957 AV651991 AV651609 BI757556 AV660296 CB054015 AV646167 AF161454 
AI937498 AA331300 NM_019101 AA243845 AV681809 AI245278 AV646060 AV660137 
AV646373 AA383229 BX105475 AV652705 AV655684 AI338771 AI825658 AV651963 

highest scoring ESTs for APOM:

AA846749 AJ245434 AA452005 AA815182 AA866141 AA933567 AF118393 AF161454 AI001769 AI207404 

Unigene Cluster for APOM:

Apolipoprotein M
Hs.534468  [show with all ESTs]
Unigene Representative Sequence: BG567934


GeneLoc Exon Structure

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

APOM expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for APOM

1 / 2 / 3

7 probe-sets matching APOM gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
37924_g_at2, 3 U95-A 3 1.00 0.33 0.99 1.33 AA846749 1.00 0.90 0.95 1
37925_r_at2, 3 U95-A 3 1.00 0.33 0.96 0.84 AJ245434 1.00 0.90 0.95 1
37923_at2, 3 U95-A 3 1.00 0.33 0.98 0.86 AA846749 1.00 0.90 0.95 1

205682_x_at2, 3 U133-A 3 1.00 0.33 -- -- NM_019101 0.60 0.83 0.73 1

214910_s_at2, 3 U133-A 3 1.00 0.33 -- -- AF161454 0.80 0.88 0.84 1

205682_x_at2 U133Plus2 3 1.00 0.33 -- -- -- -- -- -- --

214910_s_at2 U133Plus2 3 1.00 0.33 -- -- -- -- -- -- --
GeneDecks  APOM for binary patterns associated with the probe-sets selected above  
About GeneDecksing
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CTGAATGAGA

SOURCE GeneReport for Unigene cluster: Hs.534468

Expression variation in blood from EXPOLDB for APOM

UniProtKB/Swiss-Prot: APOM_HUMAN, O95445
Tissue specificity: Plasma protein. Expressed in liver and kidney

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for APOM gene from 4 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
APOM1   -- apolipoprotein M 89.18(n)
86.7(a)
474843  XM_532074.2  XP_532074.1 
chimpanzee
(Pan troglodytes)
APOM1   -- apolipoprotein M 99.29(n)
98.94(a)
462561  XM_518354.2  XP_518354.2 
rat
(Rattus norvegicus)
Apom1   -- apolipoprotein M 83.42(n)
82.89(a)
55939  NM_019373.1  NP_062246.1 
mouse
(Mus musculus)
Apom1, 5 175
apolipoprotein M1, 5 84.49(n)1
81.82(a)1
559381  NM_018816.11  NP_061286.11 
 AF1097195  AF2078205  (see all 7)
About this table        Species with no ortholog for APOM
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/17 NCBI SNPs in APOM are shown (see all 17 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 62)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 6 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs8052971,2
C,F,H31730585(-) ggtaaG/Ttccaa 1 -- ng5117Minor allele frequency- T:0.27EU EA WA NS NA 1628
--
rs8052961,2
C31730872(-) aaaaaA/Gtacaa 1 -- ng510--------
--
rs94049411,2
C31730795(+) CAGGCC/TCAAGC 1 -- ng510--------
rs7079221,2
A,C,F,H31733486(-) TTAACC/ACCTTA 1 -- int110Minor allele frequency- A:0.18MN EU EA WA NA 908
rs8052641,2
A,C,F,H31731852(-) TCCCCC/TAATCT 1 -- int112Minor allele frequency- T:0.07EA NA MN EU WA 874
rs7079211,2
C,F,H31733520(-) GACTTG/TGTGAG 1 -- int110Minor allele frequency- T:0.10EU EA WA MN 2518
rs22736121,2
F,H31733313(-) AGGGTG/ATCATA 1 -- int15Minor allele frequency- A:0.01EA EU WA 1900
--
rs31175811,2
C31732843(-) ctcacC/Tgcaag 1 -- int10--------
--
rs49472511,2
--31730641(+) atcctA/Gtaaga 1 -- ng510--------
--
rs114627331,2
--31733187(+) GGAAT-/CCATGC 1 I/T fra10--------
About this table

HapMap Linkage Disequilibrium images for APOM (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 606907

1 Novoseek disease relationship for APOM gene

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
atherosclerosis 10.97 4 17218068 (1), 18006500 (1), 17101555 (1)
About this table

Human Gene Mutation Database: APOM
Genetic Association Database: APOM
Human Genome Epidemiology Navigator: APOM (8 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/51 PubMed articles for APOM gene (see all 51 ):
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 55937 HGNC: 13916 AceView: APOM euGenes: HUgn55937 ECgene: APOM
H-InvDB: APOM
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for APOM:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for APOM-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for APOM Antibodies for APOM
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for APOM Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
 Antibodies   Primer Pairs  
 Cell Culture Products   ELISAs  
 Flow Cytometry Kits   Protease Activity Assays & Reagents  
 Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
 Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
 Recombinant & Natural Proteins  

 Recombinant Proteins (APOM)
 Antibodies (APOM)
 Chimera RNAi (APOM)
 Custom Service for Mouse Mab
 Custom Service for Rabbit Pab from Full-length Protein
  
 Search for Antibodies & Assays

 Recombinant Proteins
(Apolipoprotein M)
 Antibodies (Apolipoprotein M)
 Tagged/untagged cDNA clones
 Validated SYBR primer pairs
 Purified proteins from HEK293T cells
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 Search Tocris compounds for APOM




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for APOM

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