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APOM Gene

protein-coding   GIFtS: 60
GCID: GC06P031620

Apolipoprotein M

  See APOM-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Apolipoprotein M1 2     apo-M2
Protein G3a2 3     NG20-Like Protein2
NG202 3     Apo-M3
G3a2     ApoM3
HSPC3362     G3A3
Alternative Name: G3a, NG202     

External Ids:    HGNC: 139161   Entrez Gene: 559372   Ensembl: ENSG000002044447   OMIM: 6069075   UniProtKB: O954453   

Export aliases for APOM gene to outside databases

Previous GC identifers: GC06P031687 GC06P031390 GC06P031727 GC06P031731 GC06P031410


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for APOM Gene:
The protein encoded by this gene is an apolipoprotein and member of the lipocalin protein family. It is found
associated with high density lipoproteins and to a lesser extent with low density lipoproteins and
triglyceride-rich lipoproteins. The encoded protein is secreted through the plasma membrane but remains
membrane-bound, where it is involved in lipid transport. Alternate splicing results in both coding and non-coding
variants of this gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for APOM Gene:
APOM (apolipoprotein M) is a protein-coding gene. Diseases associated with APOM include limb ischemia, and critical limb ischemia. GO annotations related to this gene include phospholipid binding and lipid transporter activity.

UniProtKB/Swiss-Prot: APOM_HUMAN, O95445
Function: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and
stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid

Gene Wiki entry for APOM Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NT_113891.3  NT_167245.2  NT_167246.2  NT_167247.2  NT_167248.2  NT_167249.2  
NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the APOM gene promoter:
         COUP-TF1   PPAR-gamma1   STAT1   COUP-TF   COUP   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAPOM promoter sequence
   Search Chromatin IP Primers for APOM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat APOM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.33   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21

APOM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOM gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P031620:  view genomic region     (about GC identifiers)

Start:
31,620,193 bp from pter      End:
31,625,987 bp from pter
Size:
5,795 bases      Orientation:
plus strand

6 alternative locations:
Chr6+,NT_167245 2,909,250-2,911,566      Chr6+,NT_167248 2,917,308-2,919,624      Chr6+,NT_167246 2,966,560-2,968,876     
Chr6+,NT_113891.2 3,133,289-3,135,605      Chr6+,NT_167247 3,003,351-3,005,667      Chr6+,NT_167249 2,954,469-2,956,785     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: APOM_HUMAN, O95445 (See protein sequence)
Recommended Name: Apolipoprotein M  
Size: 188 amino acids; 21253 Da
3 PDB 3D structures from and Proteopedia for APOM:
2WEW (3D)        2WEX (3D)        2YG2 (3D)    
Secondary accessions: B0UX98 Q5SRP4 Q9P046 Q9UMP6
Alternative splicing: 2 isoforms:  O95445-1   O95445-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for APOM: NX_O95445

Explore proteomics data for APOM at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn135
  • Modification sites at PhosphoSitePlus

  • See APOM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243098.1  NP_061974.2  

    ENSEMBL proteins: 
     ENSP00000365083   ENSP00000365085   ENSP00000365081  

    APOM Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for APOM
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    Cloud-Clone Corp. Proteins for APOM

     
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    Search eBioscience for ELISAs for APOM 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    LCN: Lipocalins
    APOLIPO: Apolipoproteins

    2 InterPro protein domains:
     IPR022734 ApoM
     IPR011038 Calycin-like

    Graphical View of Domain Structure for InterPro Entry O95445

    ProtoNet protein and cluster: O95445

    UniProtKB/Swiss-Prot: APOM_HUMAN, O95445
    Similarity: Belongs to the calycin superfamily. Lipocalin family. Highly divergent


    Find genes that share domains with APOM           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APOM_HUMAN, O95445
    Function: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and
    stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005319lipid transporter activity IDA16682745
    GO:0005543phospholipid binding IDA--
    GO:0016209antioxidant activity IDA--
         
    Find genes that share ontologies with APOM           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for APOM:
     Decreased Hepatitis C virus re 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Apom):
     homeostasis/metabolism 

    Find genes that share phenotypes with APOM           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for APOM: Apomtm1Stf Apomtm1Cchr

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for APOM
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for APOM

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for APOM
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for APOM

    miRNA
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    Block miRNA regulation of human, mouse, rat APOM using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate APOM:
    hsa-miR-766
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat APOM

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    GenScript: all cDNA clones in your preferred vector: APOM (NM_019101)
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    APOM_HUMAN, O95445: Secreted. Note=Present in high density lipoprotein (HDL) and to a lesser extent in
    triglyceride-rich lipoproteins (TGRLP) and low density lipoproteins (LDL)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane4
    cytosol1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space ----
    GO:0005887integral component of plasma membrane TAS10531326
    GO:0034361very-low-density lipoprotein particle IDA17154273
    GO:0034362low-density lipoprotein particle IDA16682745

    Find genes that share ontologies with APOM           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for APOM About    
    See pathways by source

    SuperPathContained pathways About
    1Ca, cAMP and Lipid Signaling
    Ca, cAMP and Lipid Signaling


    Find genes that share SuperPaths with APOM           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for APOM
        Ca, cAMP and Lipid Signaling



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for APOM
    Interactions:

        GeneGlobe Interaction Network for APOM

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for APOM (O954452, 3 ENSP000003650814) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FAM203AQ9BTY72, 3MINT-65339 I2D: score=4 
    KLF6Q996122, 3, ENSP000004199234MINT-64538 I2D: score=5 STRING: ENSP00000419923
    --Q96BK83I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009749response to glucose IEA--
    GO:0033344cholesterol efflux IMP15793583
    GO:0034375high-density lipoprotein particle remodeling IMP18006500
    GO:0034380high-density lipoprotein particle assembly ISS15793583
    GO:0034384high-density lipoprotein particle clearance ISS15793583

    Find genes that share ontologies with APOM           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for APOM

    1 DrugBank Compound for APOM    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    MYRISTIC ACID-- --carrier--10592235

    5 Novoseek inferred chemical compound relationships for APOM gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholesterol 57.9 33 15542348 (5), 17526892 (3), 18490703 (3), 16682745 (2) (see all 14)
    lipid 32 3 15542348 (1), 19153651 (1)
    phospholipid 17.8 2 10531326 (1), 17101555 (1)
    acth 14.7 2 15222631 (1), 11514556 (1)
    glucose 7.6 1 15542348 (1)



    Find genes that share compounds with APOM           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for APOM gene (2 alternative transcripts): 
    NM_001256169.1  NM_019101.2  

    Unigene Cluster for APOM:

    Apolipoprotein M
    Hs.534468  [show with all ESTs]
    Unigene Representative Sequence: BG567934
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375918 ENST00000375920(uc003nvk.3) ENST00000375916(uc003nvl.3)

    miRNA
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    hsa-miR-766
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    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat APOM
      QuantiTect SYBR Green Assays in human, mouse, rat APOM
      QuantiFast Probe-based Assays in human, mouse, rat APOM

    Additional mRNA sequence: 

    AF118393.3 AF161454.1 AJ245434.1 BC020683.1 NR_045828.1 

    12 DOTS entries:

    DT.417144  DT.417143  DT.121312769  DT.95264837  DT.99945542  DT.91768627  DT.92458335  DT.121312759 
    DT.121312766  DT.452848  DT.92458314  DT.454198 

    Selected AceView cDNA sequences (see all 132):

    AV651963 AI825658 AA383229 AV646060 BX100487 AV646373 AV681809 AA331300 
    AV682741 AV652705 AI858956 AV660137 AI937498 BI757556 AV651991 AV651957 
    BX956704 AV660296 AA815182 CB054015 AV655684 NM_019101 AA243845 AV651609 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    APOM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAATGAGA
    APOM Expression
    About this image


    APOM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Mesothelial Cells Hepatic Mesenchyme
             Liver Lobule
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephros
     
     Heart (Cardiovascular System)
             Primitive Heart Tube Cells Primitive Heart Tube
    APOM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    APOM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534468

    UniProtKB/Swiss-Prot: APOM_HUMAN, O95445
    Tissue specificity: Plasma protein. Expressed in liver and kidney

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for APOM gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Apom1 , 5 apolipoprotein M1, 5 84.4(n)1
    81.38(a)1
      17 (18.59 cM)5
    559381  NM_018816.11  NP_061286.11 
     351289975 
    lizard
    (Anolis carolinensis)
    Reptilia APOM6
    apolipoprotein M
    45(a)
    1 ↔ 1
    2(194026272-194035470)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia apom1 apolipoprotein M 53.48(n)
    45.99(a)
      100037868  NM_001097309.1  NP_001090778.1 
    zebrafish
    (Danio rerio)
    Actinopterygii apom6
    apolipoprotein M
    19(a)
    1 ↔ 1
    2(42329859-42335679) ENSDARG00000076838


    ENSEMBL Gene Tree for APOM (if available)
    TreeFam Gene Tree for APOM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for APOM (see all 68)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs558808111,2
    C--31622531(+) TTATTC/TGAGAA 3 -- us2k1 int10--------
    rs1142886011,2
    C,F--31622537(+) GAGAAC/ATTATT 3 -- us2k1 int11Minor allele frequency- A:0.03WA 118
    rs8052971,2
    C,F,H--31622606(-) ggtaaG/Ttccaa 3 -- us2k1 int129Minor allele frequency- T:0.25NS EA NA 3334
    rs773225551,2
    C--31622630(+) TGCTAA/CGGGCT 3 -- us2k1 int10--------
    rs1458771301,2
    --31622728(+) TGGTGG/TTTTGT 3 -- us2k1 int10--------
    rs1850616871,2
    --31622736(+) TGTTTC/GTTTGG 3 -- us2k1 int10--------
    rs94049411,2
    C,F--31622816(+) CAGGCT/CCAAGC 3 -- us2k1 int12Minor allele frequency- C:0.11NA EA 240
    rs8052961,2
    C,F,H--31622893(-) aaaaaA/Gtacaa 3 -- us2k1 int12Minor allele frequency- G:0.12WA EA 238
    rs1508630401,2
    C--31622949(+) CTGGG-/CTCAAG 3 -- us2k1 int10--------
    rs766113451,2
    C--31623074(+) ACAGCA/CAGATT 3 -- us2k1 int10--------

    HapMap Linkage Disequilibrium report for APOM (31620193 - 31625987 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for APOM:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830627CNV Loss17160897
    dgv6581n71CNV Loss21882294
    nsv462871CNV Loss19166990
    nsv884418CNV Gain21882294

    Human Gene Mutation Database (HGMD): APOM
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing APOM
    DNA2.0 Custom Variant and Variant Library Synthesis for APOM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606907    OMIM disorders: --

    2 diseases for APOM:    
    About MalaCards
    limb ischemia    critical limb ischemia


    Find genes that share disorders with APOM           About GenesLikeMe

    1 Novoseek inferred disease relationship for APOM gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atherosclerosis 22.8 8 19909825 (3), 17218068 (1), 18006500 (1), 17101555 (1) (see all 5)

    Genetic Association Database (GAD): APOM
    Human Genome Epidemiology (HuGE) Navigator: APOM (15 documents)

    Export disorders for APOM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for APOM gene, integrated from 10 sources (see all 97):
    (articles sorted by number of sources associating them with APOM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human apolipoprotein (apoM). (PubMed id 10531326)1, 2, 3, 9 Xu N. and Dahlbaeck B. (J. Biol. Chem. 1999)
    2. Proposed lipocalin fold for apolipoprotein M based on bioinformatics and site-directed mutagenesis. (PubMed id 11418126)1, 2, 3, 9 Duan J.... Villoutreix B.O. (FEBS Lett. 2001)
    3. Evaluation of Apolipoprotein M Serum Concentration as a Biomarker of HNF-1alpha MODY. (PubMed id 18338076)1, 4, 9 Skupien J....Malecki M.T. (Rev Diabet Stud 2007)
    4. Hydrophobic ligand binding properties of the human lipocalin apolipoprotein M. (PubMed id 17525477)1, 2, 9 Ahnstrom J.... Dahlback B. (J. Lipid Res. 2007)
    5. Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population. (PubMed id 15172102)1, 4, 9 Kabbara A....Lambert J.C. (Neurosci. Lett. 2004)
    6. Serendipitous fatty acid binding reveals the structural determinants for ligand recognition in apolipoprotein M. (PubMed id 19733574)1, 2, 9 Sevvana M....Muller Y.A. (J. Mol. Biol. 2009)
    7. Apolipoprotein M promoter polymorphisms alter promoter activity and confer the susceptibility to the development of type 1 diabetes. (PubMed id 19007767)1, 4, 9 Wu X....Liu Y. (Clin. Biochem. 2009)
    8. Apolipoprotein M associates to lipoproteins through its retained signal peptide. (PubMed id 18279674)1, 2, 9 Axler O.... Dahlback B. (FEBS Lett. 2008)
    9. The signal peptide anchors apolipoprotein M in plasma lipoproteins and prevents rapid clearance of apolipoprotein M from plasma. (PubMed id 18460466)1, 2, 9 Christoffersen C.... Nielsen L.B. (J. Biol. Chem. 2008)
    10. A genetic variant of apolipoprotein M increases susceptibility to coronary artery disease in a Chinese population. (PubMed id 17973931)1, 4, 9 Xu W.W....Fan L.M. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Free Text  

      Query String
    PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55937 HGNC: 13916 AceView: APOM Ensembl:ENSG00000204444 euGenes: HUgn55937
    ECgene: APOM H-InvDB: APOM

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for APOM Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for APOM gene:
    Search GeneIP for patents involving APOM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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