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Aliases & Descriptions for APOM
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| Apo-M 3 | | ApoM 1, 3 | | G3A 3 | | G3a 1, 2 | | HSPC336 2 | | MGC22400 2 | | NG20 1, 2, 3 | | OTTHUMP00000029364 2 |
| | | Descriptions |
|---|
| NG20-like protein 2 | | Protein G3a 3 | | alternative name: G3a, NG20 2 | | apolipoprotein M 2 |
|
| | Search outside databases for aliases for APOM genePrevious GC identifers: GC06P031687 GC06P031390 GC06P031727 |
Summaries for APOM(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for APOM: The protein encoded by this gene is an apolipoprotein and member of the lipocalin protein family. It is found associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. The encoded protein is secreted through the plasma membrane but remains membrane-bound, where it is involved in lipid transport. Two transcript variants encoding two different isoforms have been found for this gene, but only one of them has been fully characterized. [provided by RefSeq] UniProtKB/Swiss-Prot: APOM_HUMAN, O95445Function: Probably involved in lipid transportGene Wiki entry for APOM |
Genomic Location for APOM
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the APOM gene 
Entrez Gene cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21APOM Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P031731:
(about GC identifiers)
Start:
|
31,731,650 bp from pter |
End:
|
31,733,966 bp from pter |
Size:
|
2,317 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000006.10 NT_007592.14 NT_113891.1 NT_113894.1
| Proteins for APOM
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: APOM_HUMAN, O95445 (See
protein sequence)Recommended Name: Apolipoprotein M Size: 188 amino acids; 21253 Da
Subcellular location: Secreted. Note=Present in high density lipoprotein (HDL) and to a lesser extent in triglyceride-rich lipoproteins (TGRLP) and low density lipoproteins (LDL)
Secondary accessions: Q9P046 Q9UMP6REFSEQ proteins: NP_061974.2 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: APOM 
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for APOM: Assays for APOM: | Protein
Domains/ Families for APOM(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: O95445 UniProtKB/Swiss-Prot: APOM_HUMAN, O95445Similarity: Belongs to the calycin superfamily. Lipocalin family. Highly divergent | Gene Function for APOM
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_019101
Applied Biosystems Silencer® siRNAs for APOM
Sigma-Aldrich siRNA for APOM  Sigma-Aldrich shRNA for APOM  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_019101                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_019101                                  untagged cDNA clone in CMV expression vector: NM_019101 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_019101
UniProtKB/Swiss-Prot: APOM_HUMAN, O95445Function: Probably involved in lipid transport1 MGI mutant phenotype (inferred from 2 alleles ) (MGI details for Apom):
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for APOM
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for APOM 
2 Interacting proteins for APOM (O954452) via UniProtKB, MINT, and/or STRINGAbout this table
5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8
): About this table
|
Drugs & Compounds for APOM(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for APOM 5 Novoseek chemical compound relationships for APOM gene
About this table
|
Transcripts for APOM(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_019101
Sigma-Aldrich siRNA for APOM  Sigma-Aldrich shRNA for APOM  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_019101 REFSEQ mRNAs for APOM gene: NM_019101.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_019101               OriGene GFP tagged cDNA clone in CMV expression vector: NM_019101                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_019101                                  untagged cDNA clone in CMV expression vector: NM_019101  Additional cDNA sequence: AF118393.3 AF161454.1 AJ245434.1 BC020683.1 11 DOTS entries: DT.417144 DT.417143 DT.121312769 DT.95264837 DT.99945542 DT.91768627 DT.121312759 DT.92458335 DT.121312766 DT.452848 DT.92458314 24/132 AceView cDNA sequences (see all 132
):AV651957 AV651991 AV651609 BI757556 AV660296 CB054015 AV646167 AF161454 AI937498 AA331300 NM_019101 AA243845 AV681809 AI245278 AV646060 AV660137 AV646373 AA383229 BX105475 AV652705 AV655684 AI338771 AI825658 AV651963
highest scoring ESTs for APOM:AA846749 AJ245434 AA452005 AA815182 AA866141 AA933567 AF118393 AF161454 AI001769 AI207404 Unigene Cluster for APOM: Apolipoprotein M Hs.534468 [show with all ESTs]Unigene Representative Sequence: BG567934
GeneLoc Exon Structure
|
Expression for APOM
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| APOM expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for APOM
1 / 2 / 3 7 probe-sets matching APOM gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CTGAATGAGA
SOURCE GeneReport for Unigene cluster: Hs.534468
Expression variation in blood from EXPOLDB for APOM UniProtKB/Swiss-Prot: APOM_HUMAN, O95445Tissue specificity: Plasma protein. Expressed in liver and kidney |
Orthologs for APOM
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for APOM gene from 4 species
About this table Species with no ortholog for APOM | Paralogs for APOM(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for APOM(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for APOM (up to first 250kb)
|
Disorders & Mutations for APOM
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 606907
1 Novoseek disease relationship for APOM gene
About this table
Human Gene Mutation Database: APOM Genetic Association Database: APOM Human Genome Epidemiology Navigator: APOM (8 documents)
|
Medical News for APOM(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for APOM (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/51 PubMed articles for APOM gene (see all 51
):- A novel human apolipoprotein (apoM). (PubMed id 10531326)1, 2, 3, 4 Xu N. and Dahlbaeck B. (1999)
- Proposed lipocalin fold for apolipoprotein M based on bioinformatics and site-directed mutagenesis. (PubMed id 11418126)1, 2, 3, 4 Duan J....Villoutreix B.O. (2001)
- Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population. (PubMed id 15172102)1, 3, 6 Kabbara A....Lambert J.C. (2004)
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)3, 4 Liu T.... Smith R.D. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)3, 4 Mungall A.J.... Beck S. (2003)
- Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)3, 4 Xie T.... Hood L. (2003)
- Effects of platelet-activating factor, tumor necrosis factor, and interleukin-1alpha on the expression of apolipoprotein M in HepG2 cells. (PubMed id 11944906)1, 3 Xu N....Nilsson-Ehle P. (2002)
- Leptin inhibits apolipoprotein M transcription and secretion in human hepatoma cell line, HepG2 cells. (PubMed id 15904876)1, 3 Luo G....Xu N. (2005)
- Correlation of apolipoprotein M with leptin and cholesterol in normal and obese subjects. (PubMed id 15542348)1, 3 Xu N....Ahren B. (2004)
|
Search for APOM
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing APOM
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing APOM
(According to HUGE)
About This Section
| -- |
Specialized Databases showing APOM(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for APOM(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for APOM:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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