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Aliases for APOLD1 Gene

Aliases for APOLD1 Gene

  • Apolipoprotein L Domain Containing 1 2 3 5
  • Vascular Early Response Gene Protein 3 4
  • VERGE 3 4
  • Apolipoprotein L Domain-Containing Protein 1 3

External Ids for APOLD1 Gene

Previous GeneCards Identifiers for APOLD1 Gene

  • GC12P012830
  • GC12P012773
  • GC12P012775
  • GC12P012776
  • GC12P012777
  • GC12P012778
  • GC12P012831
  • GC12P012648
  • GC12P012879
  • GC12P012880
  • GC12P012885

Summaries for APOLD1 Gene

Entrez Gene Summary for APOLD1 Gene

  • APOLD1 is an endothelial cell early response protein that may play a role in regulation of endothelial cell signaling and vascular function (Regard et al., 2004 [PubMed 15102925]).[supplied by OMIM, Dec 2008]

GeneCards Summary for APOLD1 Gene

APOLD1 (Apolipoprotein L Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include lipid binding.

UniProtKB/Swiss-Prot for APOLD1 Gene

  • May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May affect blood-brain permeability.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOLD1 Gene

Genomics for APOLD1 Gene

Regulatory Elements for APOLD1 Gene

Enhancers for APOLD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G012733 1.8 FANTOM5 Ensembl ENCODE dbSUPER 17 +9.6 9649 4.9 HDGF FOXA2 PKNOX1 SIN3A FEZF1 ZNF48 ZNF2 YY1 ZNF121 GATA2 CDKN1B APOLD1 DDX47 BORCS5 DUSP16 GPR19 GC12M012732 GC12M012733
GH12G012713 1.8 FANTOM5 ENCODE dbSUPER 16.9 -5.6 -5616 14.0 CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC APOLD1 DDX47 GPR19 RPL13AP20 CDKN1B MANSC1 BORCS5 DUSP16 LOC105369663 ENSG00000275560
GH12G012695 1 ENCODE 17.8 -28.9 -28920 3.2 HDGF PKNOX1 ATF1 FOXA2 ARID4B SIN3A BRCA1 ZNF2 YY1 SLC30A9 APOLD1 LOC105369663 ENSG00000240424 DUSP16 GPR19 GC12P012687 GC12P012702
GH12G012376 1.3 Ensembl ENCODE dbSUPER 10.6 -349.1 -349116 0.4 CTCF ARNT CEBPG RAD21 RFX5 YY1 ARID3A SMC3 RELB MIXL1 MANSC1 DUSP16 ENSG00000240424 CDKN1B GPR19 APOLD1 LOC105369663 GC12M012376 GC12P012364
GH12G012701 0.5 ENCODE 23.2 -24.4 -24411 0.8 GLIS1 TEAD4 EZH2 APOLD1 LOC105369663 GC12P012702 GC12P012687
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around APOLD1 on UCSC Golden Path with GeneCards custom track

Promoters for APOLD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000048976 -1217 4601 HDGF PKNOX1 FOXA2 ARNT AGO1 ZFP64 WRNIP1 SIN3A DMAP1 FEZF1

Genomic Location for APOLD1 Gene

Chromosome:
12
Start:
12,725,917 bp from pter
End:
12,829,975 bp from pter
Size:
104,059 bases
Orientation:
Plus strand

Genomic View for APOLD1 Gene

Genes around APOLD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOLD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOLD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOLD1 Gene

Proteins for APOLD1 Gene

  • Protein details for APOLD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LR9-APLD1_HUMAN
    Recommended name:
    Apolipoprotein L domain-containing protein 1
    Protein Accession:
    Q96LR9
    Secondary Accessions:
    • Q8IVR2
    • Q9H0I5

    Protein attributes for APOLD1 Gene

    Size:
    279 amino acids
    Molecular mass:
    30546 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH42478.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for APOLD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for APOLD1 Gene

Post-translational modifications for APOLD1 Gene

No Post-translational modifications

Other Protein References for APOLD1 Gene

No data available for DME Specific Peptides for APOLD1 Gene

Domains & Families for APOLD1 Gene

Protein Domains for APOLD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for APOLD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96LR9

UniProtKB/Swiss-Prot:

APLD1_HUMAN :
  • Belongs to the apolipoprotein L family.
Family:
  • Belongs to the apolipoprotein L family.
genes like me logo Genes that share domains with APOLD1: view

No data available for Gene Families for APOLD1 Gene

Function for APOLD1 Gene

Molecular function for APOLD1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May affect blood-brain permeability.
UniProtKB/Swiss-Prot Induction:
In neonatal dermal microvascular endothelial cells, by hypoxia.

Gene Ontology (GO) - Molecular Function for APOLD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with APOLD1: view
genes like me logo Genes that share phenotypes with APOLD1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for APOLD1 Gene

Localization for APOLD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOLD1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for APOLD1 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
extracellular 2
mitochondrion 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for APOLD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with APOLD1: view

Pathways & Interactions for APOLD1 Gene

SuperPathways for APOLD1 Gene

No Data Available

Interacting Proteins for APOLD1 Gene

Selected Interacting proteins: Q96LR9-APLD1_HUMAN for APOLD1 Gene via IID

Gene Ontology (GO) - Biological Process for APOLD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001666 response to hypoxia IEA --
GO:0006869 lipid transport IEA --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with APOLD1: view

No data available for Pathways by source and SIGNOR curated interactions for APOLD1 Gene

Drugs & Compounds for APOLD1 Gene

No Compound Related Data Available

Transcripts for APOLD1 Gene

Unigene Clusters for APOLD1 Gene

Apolipoprotein L domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for APOLD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a ·
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - -
SP4: - -
SP5: -
SP6:
SP7:
SP8: -
SP9: - -
SP10: -
SP11:

ExUns: 15b ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for APOLD1 Gene

GeneLoc Exon Structure for
APOLD1
ECgene alternative splicing isoforms for
APOLD1

Expression for APOLD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for APOLD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for APOLD1 Gene

This gene is overexpressed in Adipose - Subcutaneous (x5.1) and Adipose - Visceral (Omentum) (x5.0).

Protein differential expression in normal tissues from HIPED for APOLD1 Gene

This gene is overexpressed in Cerebrospinal fluid (35.9), Breast (12.6), and Heart (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for APOLD1 Gene



NURSA nuclear receptor signaling pathways regulating expression of APOLD1 Gene:

APOLD1

SOURCE GeneReport for Unigene cluster for APOLD1 Gene:

Hs.23388

mRNA Expression by UniProt/SwissProt for APOLD1 Gene:

Q96LR9-APLD1_HUMAN
Tissue specificity: Expressed in neonatal dermal microvascular endothelial cells.

Evidence on tissue expression from TISSUES for APOLD1 Gene

  • Nervous system(4.4)
  • Eye(4)
  • Thyroid gland(2.2)
genes like me logo Genes that share expression patterns with APOLD1: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for APOLD1 Gene

Orthologs for APOLD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOLD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APOLD1 34 35
  • 99.4 (n)
cow
(Bos Taurus)
Mammalia APOLD1 34 35
  • 89.16 (n)
dog
(Canis familiaris)
Mammalia APOLD1 34 35
  • 88.35 (n)
mouse
(Mus musculus)
Mammalia Apold1 34 16 35
  • 87.13 (n)
rat
(Rattus norvegicus)
Mammalia Apold1 34
  • 85.77 (n)
oppossum
(Monodelphis domestica)
Mammalia APOLD1 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves APOLD1 34 35
  • 67.41 (n)
lizard
(Anolis carolinensis)
Reptilia APOLD1 35
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia apold1 34
  • 57.71 (n)
zebrafish
(Danio rerio)
Actinopterygii apol1 35
  • 14 (a)
OneToMany
APOLD1 (3 of 4) 35
  • 12 (a)
OneToMany
APOLD1 (4 of 4) 35
  • 11 (a)
OneToMany
APOLD1 (2 of 4) 35
  • 9 (a)
OneToMany
Dr.26269 34
Species where no ortholog for APOLD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APOLD1 Gene

ENSEMBL:
Gene Tree for APOLD1 (if available)
TreeFam:
Gene Tree for APOLD1 (if available)

Paralogs for APOLD1 Gene

No data available for Paralogs for APOLD1 Gene

Variants for APOLD1 Gene

Sequence variations from dbSNP and Humsavar for APOLD1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000020586 -- 12,775,704(+) CTACA(-/T)TTTTT intron-variant
rs1000040322 -- 12,775,426(+) AGGAA(A/C)CCTAA intron-variant
rs1000055864 -- 12,743,365(+) CCATC(G/T)TTAAA intron-variant
rs1000068014 -- 12,783,174(+) GTACT(C/G)TAGCC intron-variant
rs1000072639 -- 12,748,227(+) ACCAC(A/G)GAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for APOLD1 Gene

Variant ID Type Subtype PubMed ID
esv23001 CNV loss 19812545
esv2745567 CNV deletion 23290073
esv3628624 CNV loss 21293372
nsv1046355 CNV loss 25217958
nsv1070514 CNV deletion 25765185
nsv1119932 CNV deletion 24896259
nsv1127250 CNV deletion 24896259
nsv1144608 CNV deletion 24896259
nsv53843 CNV deletion 16902084
nsv951330 CNV deletion 24416366

Variation tolerance for APOLD1 Gene

Residual Variation Intolerance Score: 52.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.63; 65.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for APOLD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
APOLD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOLD1 Gene

Disorders for APOLD1 Gene

Relevant External Links for APOLD1

Genetic Association Database (GAD)
APOLD1
Human Genome Epidemiology (HuGE) Navigator
APOLD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APOLD1

No disorders were found for APOLD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APOLD1 Gene

Publications for APOLD1 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Verge: a novel vascular early response gene. (PMID: 15102925) Regard J.B. … Worley P.F. (J. Neurosci. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for APOLD1 Gene

Sources for APOLD1 Gene

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