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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

APOLD1 Gene

protein-coding   GIFtS: 44
GCID: GC12P012880

Apolipoprotein L Domain Containing 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Apolipoprotein L Domain Containing 11 2
VERGE2 3 5
Vascular Early Response Gene Protein2 3
Apolipoprotein L Domain-Containing Protein 12

External Ids:    HGNC: 252681   Entrez Gene: 815752   Ensembl: ENSG000001788787   OMIM: 6124565   UniProtKB: Q96LR93   

Export aliases for APOLD1 gene to outside databases

Previous GC identifers: GC12P012830 GC12P012773 GC12P012775 GC12P012776 GC12P012777 GC12P012778 GC12P012831 GC12P012648 GC12P012879


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for APOLD1 Gene:
APOLD1 is an endothelial cell early response protein that may play a role in regulation of endothelial cell
signaling and vascular function (Regard et al., 2004 (PubMed 15102925)).(supplied by OMIM, Dec 2008)

GeneCards Summary for APOLD1 Gene: 
APOLD1 (apolipoprotein L domain containing 1) is a protein-coding gene. Diseases associated with APOLD1 include rectum cancer, and rectal neoplasm. GO annotations related to this gene include lipid binding.

UniProtKB/Swiss-Prot: APLD1_HUMAN, Q96LR9
Function: May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May
affect blood-brain permeability




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009714.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the APOLD1 gene promoter:
         Pax-5   Pbx1a   MyoD   Nkx2-5   GATA-1   POU2F1   FOXO4   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAPOLD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for APOLD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOLD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.1   Ensembl cytogenetic band:  12p13.1   HGNC cytogenetic band: 12p13.2

APOLD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOLD1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P012880:  view genomic region     (about GC identifiers)

Start:
12,878,851 bp from pter      End:
12,944,400 bp from pter
Size:
65,550 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: APLD1_HUMAN, Q96LR9 (See protein sequence)
Recommended Name: Apolipoprotein L domain-containing protein 1  
Size: 279 amino acids; 30546 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (Probable)
Sequence caution: Sequence=AAH42478.1; Type=Erroneous initiation;
Secondary accessions: Q8IVR2 Q9H0I5
Alternative splicing: 2 isoforms:  Q96LR9-1   Q96LR9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for APOLD1: NX_Q96LR9

Explore proteomics data for APOLD1 at MOPED 

APOLD1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

APOLD1 Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_001123887.1  NP_110444.3  

ENSEMBL proteins: 
 ENSP00000324277   ENSP00000348998  

Human Recombinant Protein Products for APOLD1: 
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Cloud-Clone Corp. Proteins for APOLD1 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--
GO:0005886plasma membrane IEA--
GO:0016021integral to membrane IEA--

APOLD1 for ontologies           About GeneDecksing



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Cloud-Clone Corp. CLIAs for APOLD1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR008405 ApoL

Graphical View of Domain Structure for InterPro Entry Q96LR9

ProtoNet protein and cluster: Q96LR9

UniProtKB/Swiss-Prot: APLD1_HUMAN, Q96LR9
Similarity: Belongs to the apolipoprotein L family


APOLD1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: APLD1_HUMAN, Q96LR9
Function: May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May
affect blood-brain permeability
Induction: In neonatal dermal microvascular endothelial cells, by hypoxia

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008289lipid binding IEA--
     
APOLD1 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for APOLD1 
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for APOLD1 
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miRNA
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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for APOLD1

1 Interacting protein for APOLD1 (Q96LR93) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
SMURF2Q9HAU43I2D: score=1 
About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001525angiogenesis IEA--
GO:0001666response to hypoxia IEA--
GO:0006869lipid transport IEA--
GO:0030154cell differentiation IEA--
GO:0042118endothelial cell activation IEA--

APOLD1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for APOLD1 (APLD1)

Search CenterWatch for drugs/clinical trials and news about APOLD1 / APLD1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for APOLD1 gene (2 alternative transcripts): 
NM_001130415.1  NM_030817.2  

Unigene Cluster for APOLD1:

Apolipoprotein L domain containing 1
Hs.23388  [show with all ESTs]
Unigene Representative Sequence: NM_001130415
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000326765(uc001rau.4) ENST00000356591(uc001raw.4)
miRNA
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8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate APOLD1 (see all 39):
hsa-miR-4328 hsa-miR-411 hsa-miR-200a hsa-miR-128 hsa-miR-141 hsa-miR-4314 hsa-miR-330-3p hsa-miR-23a
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for APOLD1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APOLD1
Clone
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Additional mRNA sequence: 

AK024963.1 AK225176.1 AK314392.1 AL136783.1 BC042478.1 BC126433.1 BC126435.1 

7 DOTS entries:

DT.86847186  DT.97791113  DT.100893967  DT.121190023  DT.92065595  DT.97763185  DT.100713211 

24/515 AceView cDNA sequences (see all 515):

BQ073685 AI275614 BQ774582 BQ771657 AA909558 AA635940 AW273701 AI421673 
BF001998 BQ420419 CR599748 BU620345 AI338321 AI371080 CR621735 CR606352 
CF456364 CR601241 BU630094 AI559661 AA609015 BC009379 BX369130 BF724429 

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for APOLD1 (see all 11)    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a ·
SP1:                    -           -                       -           -           -                             -           -                       -     -   
SP2:                                                        -           -           -                             -     -     -                       -     -   
SP3:                                                                    -           -                                                                           
SP4:                                                        -           -                                                                                       
SP5:                                                                                                                          -                                 

ExUns: 15b ^ 16a · 16b
SP1:                  
SP2:                  
SP3:                  
SP4:                  
SP5:                  


ECgene alternative splicing isoforms for APOLD1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

APOLD1 expression in normal human tissues (normalized intensities)      APOLD1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TCAAGCAATC
APOLD1 Expression
About this image


APOLD1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/5 selected tissues (see all 5) fully expand
 
 Melanocytes (Integumentary System)    fully expand to see all 2 entries
         Human EpiDermal Melanocytes (HEM)   
 
 Epidermis (Integumentary System)    fully expand to see all 2 entries
         Human EpiDermal Melanocytes (HEM)   
 
 Heart (Cardiovascular System)
         heart/ventricle   
 
 Umbilical Cord (Extraembryonic Tissues)
         Umbilical cord blood-derived endothelial progenitor cells
 
 Endothelium (Cardiovascular System)
         Umbilical cord blood-derived endothelial progenitor cells

See APOLD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for APOLD1

SOURCE GeneReport for Unigene cluster: Hs.23388

UniProtKB/Swiss-Prot: APLD1_HUMAN, Q96LR9
Tissue specificity: Expressed in neonatal dermal microvascular endothelial cells

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOLD1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for APOLD1 gene from 4/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Apold11 , 5 apolipoprotein L domain containing 11, 5 87.13(n)1
88.21(a)1
  6 (65.77 cM)5
3818231  NM_001109914.11  NP_001103384.11 
 1349820015 
chicken
(Gallus gallus)
Aves APOLD11 apolipoprotein L domain containing 1 67.41(n)
61.61(a)
  769889  XM_003640378.1  XP_003640426.1 
lizard
(Anolis carolinensis)
Reptilia APOLD16
Uncharacterized protein
40(a)
1 ↔ 1
5(27598925-27599569)
zebrafish
(Danio rerio)
Actinopterygii Dr.262692 Transcribed sequence 81.82(n)    CD606283.1 


ENSEMBL Gene Tree for APOLD1 (if available)
TreeFam Gene Tree for APOLD1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1375 SNPs in APOLD1 are shown (see all 1375)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs3764391861,2
C--12876884(+) CTGGCA/TGTGCC 1 -- us2k10--------
rs1452482061,2
--12877177(+) TCGCCA/GACCCT 1 -- us2k10--------
rs1165773601,2
F--12877251(+) CGAAAG/ACCCGC 1 -- us2k11Minor allele frequency- A:0.03WA 118
rs610243561,2
C,F--12877367(+) GCCCCC/TATCGC 1 -- us2k11Minor allele frequency- T:0.40EA 120
rs1858041011,2
--12877396(+) CGGGGA/GCCTGG 1 -- us2k10--------
rs1890417251,2
--12877424(+) GAAATA/GTGGGT 1 -- us2k10--------
rs1116160101,2
C--12877428(+) TGTGGG/CTTTGG 1 -- us2k11Minor allele frequency- C:0.50CSA 2
rs1476027531,2
--12877521(+) CCGCCC/TCGGCC 1 -- us2k10--------
rs745501181,2
C--12877663(+) CTCCTC/GTCTGG 1 -- us2k10--------
rs343251,2
C,F,A--12877692(+) CTTTTC/TAAAAC 1 -- us2k1 tfbs38Minor allele frequency- T:0.48MN NA CSA WA EA 550

HapMap Linkage Disequilibrium report for APOLD1 (12878851 - 12944400 bp)

Structural Variations
     Database of Genomic Variants (DGV) 8 variations for APOLD1:    About this table     
Variant IDTypeSubtypePubMed ID
esv2745567CNV Deletion23290073
esv267412CNV Insertion20981092
esv273911CNV Insertion20981092
nsv898812CNV Loss21882294
esv23001CNV Loss19812545
nsv53843CNV Loss16902084
nsv898813CNV Loss21882294
nsv898811CNV Gain21882294

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SeqTarget long-range PCR primers for resequencing APOLD1
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 612456    OMIM disorders: --

16 diseases for APOLD1:    About MalaCards
rectum cancer    rectal neoplasm    anus neoplasm    anus disease
rectal prolapse    dracunculiasis    anus cancer    diverticulitis
intestinal obstruction    proctitis    constipation    endotheliitis
diarrhea    hypoxia    adenoma    colorectal cancer

13 diseases from the University of Copenhagen DISEASES database for APOLD1:
Rectal neoplasm     Carcinoma     Anus disease     Colorectal cancer
Rectal prolapse     Anus cancer     Adenoma     Constipation
Proctitis     Intestinal obstruction     Anus neoplasm     Diarrhea
Diverticulitis

APOLD1 for disorders           About GeneDecksing

Genetic Association Database (GAD): APOLD1
Human Genome Epidemiology (HuGE) Navigator: APOLD1 (3 documents)

Export disorders for APOLD1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for APOLD1 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with APOLD1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
  2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Verge: a novel vascular early response gene. (PubMed id 15102925)1, 2 Regard J.B.... Worley P.F. (2004)
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  6. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
  7. Proteomic analysis of integrin-associated complexes i dentifies RCC2 as a dual regulator of Rac1 and Arf6. (PubMed id 19738201)1 Humphries J.D....Humphries M.J. (2009)
  8. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
  9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  10. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 81575 HGNC: 25268 AceView: DDX47andDKFZP434F0318 Ensembl:ENSG00000178878 euGenes: HUgn81575
ECgene: APOLD1 H-InvDB: APOLD1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for APOLD1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for APOLD1 gene:
Search GeneIP for patents involving APOLD1

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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