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Aliases for APOLD1 Gene

Aliases for APOLD1 Gene

  • Apolipoprotein L Domain Containing 1 2 3
  • Vascular Early Response Gene Protein 3 4
  • VERGE 3 4

External Ids for APOLD1 Gene

Previous GeneCards Identifiers for APOLD1 Gene

  • GC12P012830
  • GC12P012773
  • GC12P012775
  • GC12P012776
  • GC12P012777
  • GC12P012778
  • GC12P012831
  • GC12P012648
  • GC12P012879
  • GC12P012880
  • GC12P012885

Summaries for APOLD1 Gene

Entrez Gene Summary for APOLD1 Gene

  • APOLD1 is an endothelial cell early response protein that may play a role in regulation of endothelial cell signaling and vascular function (Regard et al., 2004 [PubMed 15102925]).[supplied by OMIM, Dec 2008]

GeneCards Summary for APOLD1 Gene

APOLD1 (Apolipoprotein L Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include lipid binding.

UniProtKB/Swiss-Prot for APOLD1 Gene

  • May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May affect blood-brain permeability.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOLD1 Gene

Genomics for APOLD1 Gene

Regulatory Elements for APOLD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for APOLD1 Gene

Chromosome:
12
Start:
12,725,917 bp from pter
End:
12,829,975 bp from pter
Size:
104,059 bases
Orientation:
Plus strand

Genomic View for APOLD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APOLD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOLD1 Gene

Proteins for APOLD1 Gene

  • Protein details for APOLD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LR9-APLD1_HUMAN
    Recommended name:
    Apolipoprotein L domain-containing protein 1
    Protein Accession:
    Q96LR9
    Secondary Accessions:
    • Q8IVR2
    • Q9H0I5

    Protein attributes for APOLD1 Gene

    Size:
    279 amino acids
    Molecular mass:
    30546 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH42478.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for APOLD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for APOLD1 Gene

Proteomics data for APOLD1 Gene at MOPED

Post-translational modifications for APOLD1 Gene

No Post-translational modifications

Other Protein References for APOLD1 Gene

No data available for DME Specific Peptides for APOLD1 Gene

Domains & Families for APOLD1 Gene

Protein Domains for APOLD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for APOLD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96LR9

UniProtKB/Swiss-Prot:

APLD1_HUMAN :
  • Belongs to the apolipoprotein L family.
Family:
  • Belongs to the apolipoprotein L family.
genes like me logo Genes that share domains with APOLD1: view

No data available for Gene Families for APOLD1 Gene

Function for APOLD1 Gene

Molecular function for APOLD1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May affect blood-brain permeability.
UniProtKB/Swiss-Prot Induction:
In neonatal dermal microvascular endothelial cells, by hypoxia.

Gene Ontology (GO) - Molecular Function for APOLD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with APOLD1: view

Phenotypes for APOLD1 Gene

GenomeRNAi human phenotypes for APOLD1:
genes like me logo Genes that share phenotypes with APOLD1: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APOLD1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for APOLD1 Gene

Localization for APOLD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOLD1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOLD1 Gene COMPARTMENTS Subcellular localization image for APOLD1 gene
Compartment Confidence
plasma membrane 3
extracellular 2

Gene Ontology (GO) - Cellular Components for APOLD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with APOLD1: view

Pathways & Interactions for APOLD1 Gene

SuperPathways for APOLD1 Gene

No Data Available

Interacting Proteins for APOLD1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000324277%0d%0a9606.ENSP00000346839%0d%0a
Selected Interacting proteins: Q96LR9-APLD1_HUMAN ENSP00000324277 for APOLD1 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for APOLD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001666 response to hypoxia IEA --
GO:0006869 lipid transport IEA --
GO:0030154 cell differentiation IEA --
GO:0042118 endothelial cell activation IEA --
genes like me logo Genes that share ontologies with APOLD1: view

No data available for Pathways by source and SIGNOR curated interactions for APOLD1 Gene

Drugs & Compounds for APOLD1 Gene

No Compound Related Data Available

Transcripts for APOLD1 Gene

Unigene Clusters for APOLD1 Gene

Apolipoprotein L domain containing 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APOLD1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for APOLD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a ·
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - -
SP4: - -
SP5: -
SP6:
SP7:
SP8: -
SP9: - -
SP10: -
SP11:

ExUns: 15b ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for APOLD1 Gene

GeneLoc Exon Structure for
APOLD1
ECgene alternative splicing isoforms for
APOLD1

Expression for APOLD1 Gene

mRNA expression in normal human tissues for APOLD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for APOLD1 Gene

This gene is overexpressed in Adipose - Subcutaneous (x5.1) and Adipose - Visceral (Omentum) (x5.0).

Protein differential expression in normal tissues from HIPED for APOLD1 Gene

This gene is overexpressed in Cerebrospinal fluid (35.9), Breast (12.6), and Heart (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for APOLD1 Gene



SOURCE GeneReport for Unigene cluster for APOLD1 Gene Hs.23388

mRNA Expression by UniProt/SwissProt for APOLD1 Gene

Q96LR9-APLD1_HUMAN
Tissue specificity: Expressed in neonatal dermal microvascular endothelial cells.
genes like me logo Genes that share expression patterns with APOLD1: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for APOLD1 Gene

Orthologs for APOLD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOLD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia APOLD1 35
  • 89.16 (n)
  • 90.65 (a)
APOLD1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia APOLD1 35
  • 88.35 (n)
  • 85.37 (a)
APOLD1 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Apold1 35
  • 87.13 (n)
  • 88.21 (a)
Apold1 16
Apold1 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia APOLD1 35
  • 99.4 (n)
  • 99.64 (a)
APOLD1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Apold1 35
  • 85.77 (n)
  • 87.8 (a)
oppossum
(Monodelphis domestica)
Mammalia APOLD1 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves APOLD1 35
  • 67.41 (n)
  • 61.61 (a)
APOLD1 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia APOLD1 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia apold1 35
  • 57.71 (n)
  • 53.76 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.26269 35
apol1 36
  • 14 (a)
OneToMany
APOLD1 (2 of 4) 36
  • 9 (a)
OneToMany
APOLD1 (3 of 4) 36
  • 12 (a)
OneToMany
APOLD1 (4 of 4) 36
  • 11 (a)
OneToMany
Species with no ortholog for APOLD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APOLD1 Gene

ENSEMBL:
Gene Tree for APOLD1 (if available)
TreeFam:
Gene Tree for APOLD1 (if available)

Paralogs for APOLD1 Gene

No data available for Paralogs for APOLD1 Gene

Variants for APOLD1 Gene

Sequence variations from dbSNP and Humsavar for APOLD1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs34322 -- 12,726,636(+) ACGAG(C/T)TTAAC intron-variant
rs716990 -- 12,752,572(-) AAGAG(A/C)TTGTA intron-variant
rs732319 -- 12,782,546(+) ACTTG(C/T)CTCTA intron-variant
rs745084 -- 12,782,799(+) GAAGT(C/T)TGAGG intron-variant
rs1045825 -- 12,791,412(+) TTCCC(A/C)CTGTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for APOLD1 Gene

Variant ID Type Subtype PubMed ID
esv2745567 CNV Deletion 23290073
nsv898811 CNV Gain 21882294
nsv898812 CNV Loss 21882294
nsv898813 CNV Loss 21882294
esv23001 CNV Loss 19812545
nsv53843 CNV Loss 16902084
esv267412 CNV Insertion 20981092
esv273911 CNV Insertion 20981092

Variation tolerance for APOLD1 Gene

Residual Variation Intolerance Score: 52.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.63; 65.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for APOLD1 Gene

HapMap Linkage Disequilibrium report
APOLD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOLD1 Gene

Disorders for APOLD1 Gene

Relevant External Links for APOLD1

Genetic Association Database (GAD)
APOLD1
Human Genome Epidemiology (HuGE) Navigator
APOLD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APOLD1
genes like me logo Genes that share disorders with APOLD1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APOLD1 Gene

Publications for APOLD1 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 67
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 67
  3. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 67
  4. Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. (PMID: 19738201) Humphries J.D. … Humphries M.J. (Sci Signal 2009) 67
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 67

Products for APOLD1 Gene

Sources for APOLD1 Gene

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