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Aliases for APOL6 Gene

Aliases for APOL6 Gene

  • Apolipoprotein L6 2 3 5
  • Apolipoprotein L-VI 3 4
  • APOL-VI 3 4
  • Apolipoprotein L, 6 3
  • APOLVI 3

External Ids for APOL6 Gene

Previous GeneCards Identifiers for APOL6 Gene

  • GC22P032687
  • GC22P034316
  • GC22P034368
  • GC22P036044
  • GC22P019006

Summaries for APOL6 Gene

Entrez Gene Summary for APOL6 Gene

  • This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOL6 Gene

APOL6 (Apolipoprotein L6) is a Protein Coding gene. Among its related pathways are Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF). GO annotations related to this gene include lipid binding. An important paralog of this gene is APOL5.

UniProtKB/Swiss-Prot for APOL6 Gene

  • May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.

Gene Wiki entry for APOL6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOL6 Gene

Genomics for APOL6 Gene

Regulatory Elements for APOL6 Gene

Promoters for APOL6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around APOL6 on UCSC Golden Path with GeneCards custom track

Genomic Location for APOL6 Gene

Chromosome:
22
Start:
35,648,360 bp from pter
End:
35,668,409 bp from pter
Size:
20,050 bases
Orientation:
Plus strand

Genomic View for APOL6 Gene

Genes around APOL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOL6 Gene

Proteins for APOL6 Gene

  • Protein details for APOL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWW8-APOL6_HUMAN
    Recommended name:
    Apolipoprotein L6
    Protein Accession:
    Q9BWW8
    Secondary Accessions:
    • Q5R3S1
    • Q658J1
    • Q8IXX6
    • Q9UGG1

    Protein attributes for APOL6 Gene

    Size:
    343 amino acids
    Molecular mass:
    38128 Da
    Quaternary structure:
    No Data Available

neXtProt entry for APOL6 Gene

Proteomics data for APOL6 Gene at MOPED

Post-translational modifications for APOL6 Gene

  • Ubiquitination at Lys 220 and Lys 231
  • Modification sites at PhosphoSitePlus

Other Protein References for APOL6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for APOL6 Gene

Domains & Families for APOL6 Gene

Gene Families for APOL6 Gene

Protein Domains for APOL6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for APOL6 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BWW8

UniProtKB/Swiss-Prot:

APOL6_HUMAN :
  • Belongs to the apolipoprotein L family.
Family:
  • Belongs to the apolipoprotein L family.
genes like me logo Genes that share domains with APOL6: view

Function for APOL6 Gene

Molecular function for APOL6 Gene

UniProtKB/Swiss-Prot Function:
May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.
genes like me logo Genes that share phenotypes with APOL6: view

Animal Model Products

miRNA for APOL6 Gene

miRTarBase miRNAs that target APOL6

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for APOL6 Gene

Localization for APOL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOL6 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOL6 Gene COMPARTMENTS Subcellular localization image for APOL6 gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 3
cytoskeleton 2
extracellular 2
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for APOL6 Gene

Pathways & Interactions for APOL6 Gene

genes like me logo Genes that share pathways with APOL6: view

Pathways by source for APOL6 Gene

Interacting Proteins for APOL6 Gene

Gene Ontology (GO) - Biological Process for APOL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042157 lipoprotein metabolic process IEA --
genes like me logo Genes that share ontologies with APOL6: view

No data available for SIGNOR curated interactions for APOL6 Gene

Drugs & Compounds for APOL6 Gene

No Compound Related Data Available

Transcripts for APOL6 Gene

mRNA/cDNA for APOL6 Gene

Unigene Clusters for APOL6 Gene

Apolipoprotein L, 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APOL6 Gene

No ASD Table

Relevant External Links for APOL6 Gene

GeneLoc Exon Structure for
APOL6
ECgene alternative splicing isoforms for
APOL6

Expression for APOL6 Gene

mRNA expression in normal human tissues for APOL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for APOL6 Gene

This gene is overexpressed in Liver (48.5), Platelet (10.7), and Heart (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for APOL6 Gene



SOURCE GeneReport for Unigene cluster for APOL6 Gene Hs.257352

mRNA Expression by UniProt/SwissProt for APOL6 Gene

Q9BWW8-APOL6_HUMAN
Tissue specificity: Widely expressed; highly expressed in the uterus, fetal brain and spinal cord, also detected in heart, liver, lung, colon, spleen, thymus, prostate, placenta, adrenal gland, salivary and mammary gland.
genes like me logo Genes that share expression patterns with APOL6: view

Protein tissue co-expression partners for APOL6 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for APOL6 Gene

Orthologs for APOL6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APOL6 35
  • 98.93 (n)
  • 97.38 (a)
APOL6 36
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia APOL6 36
  • 50 (a)
OneToOne
APOL6 35
  • 71.21 (n)
  • 57.14 (a)
dog
(Canis familiaris)
Mammalia APOL6 35
  • 68.97 (n)
  • 51.21 (a)
APOL6 36
  • 49 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Apol6 16
Apol6 35
  • 63.78 (n)
  • 48.44 (a)
Apol6 36
  • 39 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 25 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 36 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 29 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii APOL4 36
  • 11 (a)
OneToMany
Species with no ortholog for APOL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APOL6 Gene

ENSEMBL:
Gene Tree for APOL6 (if available)
TreeFam:
Gene Tree for APOL6 (if available)

Paralogs for APOL6 Gene

Paralogs for APOL6 Gene

(5) SIMAP similar genes for APOL6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with APOL6: view

Variants for APOL6 Gene

Sequence variations from dbSNP and Humsavar for APOL6 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs5999923 - 35,659,083(+) TATAA(A/T)CTTAG reference, missense
rs1001325 -- 35,654,599(+) acaca(C/T)gtata intron-variant
rs1540294 -- 35,654,269(+) tctcc(A/C)gtctc intron-variant
rs1540295 -- 35,654,353(+) agcag(C/T)ccccc intron-variant
rs1540296 -- 35,655,145(+) agttc(C/T)aagcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for APOL6 Gene

Variant ID Type Subtype PubMed ID
nsv511076 CNV Complex 20534489

Variation tolerance for APOL6 Gene

Residual Variation Intolerance Score: 95.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for APOL6 Gene

HapMap Linkage Disequilibrium report
APOL6
Human Gene Mutation Database (HGMD)
APOL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOL6 Gene

Disorders for APOL6 Gene

Relevant External Links for APOL6

Genetic Association Database (GAD)
APOL6
Human Genome Epidemiology (HuGE) Navigator
APOL6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APOL6

No disorders were found for APOL6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APOL6 Gene

Publications for APOL6 Gene

  1. The human apolipoprotein L gene cluster: identification, classification, and sites of distribution. (PMID: 11374903) Page N.M. … Lowry P.J. (Genomics 2001) 2 3 4 67
  2. Apolipoprotein l6, a novel proapoptotic Bcl-2 homology 3-only protein, induces mitochondria-mediated apoptosis in cancer cells. (PMID: 15671246) Liu Z. … Hu C.A. (Mol. Cancer Res. 2005) 2 3 23
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Polymorphisms in lipid metabolism related miRNA binding sites and risk of metabolic syndrome. (PMID: 23911300) Ye Q. … Zhou L. (Gene 2013) 3
  5. The global gene-expression profiles of U-937 human macrophages treated with Tat peptide and Tat-FITC conjugate. (PMID: 22632162) Lin C.W. … Jan M.S. (J Drug Target 2012) 3

Products for APOL6 Gene

Sources for APOL6 Gene

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