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Aliases for APOL6 Gene

Aliases for APOL6 Gene

  • Apolipoprotein L, 6 2 3
  • Apolipoprotein L-VI 3 4
  • APOL-VI 3 4
  • Apolipoprotein L6 3
  • APOLVI 3

External Ids for APOL6 Gene

Previous GeneCards Identifiers for APOL6 Gene

  • GC22P032687
  • GC22P034316
  • GC22P034368
  • GC22P036044
  • GC22P019006

Summaries for APOL6 Gene

Entrez Gene Summary for APOL6 Gene

  • This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOL6 Gene

APOL6 (Apolipoprotein L, 6) is a Protein Coding gene. Among its related pathways are Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF). GO annotations related to this gene include lipid binding and lipid transporter activity. An important paralog of this gene is APOL5.

UniProtKB/Swiss-Prot for APOL6 Gene

  • May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles

Gene Wiki entry for APOL6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOL6 Gene

Genomics for APOL6 Gene

Regulatory Elements for APOL6 Gene

Genomic Location for APOL6 Gene

Start:
35,648,377 bp from pter
End:
35,668,409 bp from pter
Size:
20,033 bases
Orientation:
Plus strand

Genomic View for APOL6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APOL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOL6 Gene

Proteins for APOL6 Gene

  • Protein details for APOL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWW8-APOL6_HUMAN
    Recommended name:
    Apolipoprotein L6
    Protein Accession:
    Q9BWW8
    Secondary Accessions:
    • Q5R3S1
    • Q658J1
    • Q8IXX6
    • Q9UGG1

    Protein attributes for APOL6 Gene

    Size:
    343 amino acids
    Molecular mass:
    38128 Da
    Quaternary structure:
    No Data Available

neXtProt entry for APOL6 Gene

Proteomics data for APOL6 Gene at MOPED

Post-translational modifications for APOL6 Gene

  • Ubiquitination at Lys220 and Lys231
  • Modification sites at PhosphoSitePlus

Other Protein References for APOL6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for APOL6 Gene

Domains for APOL6 Gene

Gene Families for APOL6 Gene

HGNC:

Protein Domains for APOL6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for APOL6 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BWW8

UniProtKB/Swiss-Prot:

APOL6_HUMAN :
  • Q9BWW8
Family:
  • Belongs to the apolipoprotein L family.
genes like me logo Genes that share domains with APOL6: view

Function for APOL6 Gene

Molecular function for APOL6 Gene

UniProtKB/Swiss-Prot Function: May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles

Gene Ontology (GO) - Molecular Function for APOL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with APOL6: view

Phenotypes for APOL6 Gene

GenomeRNAi human phenotypes for APOL6:
genes like me logo Genes that share phenotypes with APOL6: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APOL6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for APOL6 Gene

Localization for APOL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOL6 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOL6 Gene COMPARTMENTS Subcellular localization image for APOL6 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 3
plasma membrane 3
extracellular 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for APOL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with APOL6: view

Pathways for APOL6 Gene

genes like me logo Genes that share pathways with APOL6: view

Pathways by source for APOL6 Gene

Interacting Proteins for APOL6 Gene

Gene Ontology (GO) - Biological Process for APOL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport IEA --
GO:0042157 lipoprotein metabolic process IEA --
genes like me logo Genes that share ontologies with APOL6: view

Transcripts for APOL6 Gene

mRNA/cDNA for APOL6 Gene

Unigene Clusters for APOL6 Gene

Apolipoprotein L, 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APOL6

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for APOL6 Gene

No ASD Table

Relevant External Links for APOL6 Gene

GeneLoc Exon Structure for
APOL6
ECgene alternative splicing isoforms for
APOL6

Expression for APOL6 Gene

mRNA expression in normal human tissues for APOL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for APOL6 Gene

SOURCE GeneReport for Unigene cluster for APOL6 Gene Hs.257352

mRNA Expression by UniProt/SwissProt for APOL6 Gene

Q9BWW8-APOL6_HUMAN
Tissue specificity: Widely expressed; highly expressed in the uterus, fetal brain and spinal cord, also detected in heart, liver, lung, colon, spleen, thymus, prostate, placenta, adrenal gland, salivary and mammary gland
genes like me logo Genes that share expressions with APOL6: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for APOL6 Gene

Orthologs for APOL6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APOL6 35
  • 98.93 (n)
  • 97.38 (a)
APOL6 36
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia APOL6 35
  • 71.21 (n)
  • 57.14 (a)
APOL6 36
  • 50 (a)
OneToOne
dog
(Canis familiaris)
Mammalia APOL6 35
  • 68.97 (n)
  • 51.21 (a)
APOL6 36
  • 49 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Apol6 35
  • 63.78 (n)
  • 48.44 (a)
Apol6 16
Apol6 36
  • 39 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 25 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 36 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 29 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii APOL4 36
  • 11 (a)
OneToMany
Species with no ortholog for APOL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APOL6 Gene

ENSEMBL:
Gene Tree for APOL6 (if available)
TreeFam:
Gene Tree for APOL6 (if available)

Paralogs for APOL6 Gene

Paralogs for APOL6 Gene

Selected SIMAP similar genes for APOL6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with APOL6: view

Variants for APOL6 Gene

Sequence variations from dbSNP and Humsavar for APOL6 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs7863 -- 35,666,124(-) CTGAT(A/T)ATGTA utr-variant-3-prime
rs1001325 -- 35,654,599(+) acaca(C/T)gtata intron-variant
rs1134077 -- 35,664,801(+) gtgtc(C/T)ttttt utr-variant-3-prime
rs1142737 -- 35,661,247(+) tatct(A/G)ctcgg utr-variant-3-prime
rs1540294 -- 35,654,269(+) tctcc(A/C)gtctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for APOL6 Gene

Variant ID Type Subtype PubMed ID
nsv511076 CNV Complex 20534489

Relevant External Links for APOL6 Gene

HapMap Linkage Disequilibrium report
APOL6
Human Gene Mutation Database (HGMD)
APOL6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOL6 Gene

Disorders for APOL6 Gene

Relevant External Links for APOL6

Genetic Association Database (GAD)
APOL6
Human Genome Epidemiology (HuGE) Navigator
APOL6
genes like me logo Genes that share disorders with APOL6: view

No data available for UniProtKB/Swiss-Prot for APOL6 Gene

Publications for APOL6 Gene

  1. Apolipoprotein l6, a novel proapoptotic Bcl-2 homology 3-only protein, induces mitochondria-mediated apoptosis in cancer cells. (PMID: 15671246) Liu Z. … Hu C.A. (Mol. Cancer Res. 2005) 2 3 23
  2. The human apolipoprotein L gene cluster: identification, classification, and sites of distribution. (PMID: 11374903) Page N.M. … Lowry P.J. (Genomics 2001) 2 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  5. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4

Products for APOL6 Gene

Sources for APOL6 Gene

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