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APOL5 Gene(Protein Coding)

Apolipoprotein L5

GCID:
GC22P035713
GIFtS:
46
Genes Participants
UDN Logo

Aliases for APOL5 Gene

Aliases for APOL5 Gene

  • Apolipoprotein L5 2 3 5
  • Apolipoprotein L-V 3 4
  • APOL-V 3 4
  • Apolipoprotein L, 5 3
  • APOLV 3

External Ids for APOL5 Gene

Previous GeneCards Identifiers for APOL5 Gene

  • GC22P032757
  • GC22P034385
  • GC22P034438
  • GC22P036113
  • GC22P019076

Summaries for APOL5 Gene

Entrez Gene Summary for APOL5 Gene

  • This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOL5 Gene

APOL5 (Apolipoprotein L5) is a Protein Coding gene. Among its related pathways are Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF). GO annotations related to this gene include lipid binding and high-density lipoprotein particle binding. An important paralog of this gene is APOL6.

UniProtKB/Swiss-Prot for APOL5 Gene

  • May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOL5 Gene

Genomics for APOL5 Gene

Products:

  1. Regulatory Element

Regulatory Elements for APOL5 Gene

Enhancers for APOL5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G035646 1.3 ENCODE dbSUPER 4.8 -60.1 -60092 4.1 PKNOX1 FOXA2 WRNIP1 ARID4B ZNF48 YY1 ZNF121 FOS PPARG KAT8 APOL6 APOL5 MB
GH22G035659 1.2 Ensembl ENCODE dbSUPER 4.5 -46.9 -46856 4.9 PKNOX1 FOXA2 YY1 ZNF335 POLR2A FOS PRDM10 EGR2 HLF ZNF398 MB APOL5 GC22P035676 APOL6
GH22G035733 0.5 ENCODE 8.4 +25.8 25762 1.0 CTCF ZNF24 HNF4A NR2F2 APOL6 MB APOL5 GC22M035729
GH22G035705 0.6 ENCODE 0.7 -3.0 -2997 0.8 JUN BHLHE40 CEBPB EP300 JUND GATA2 FOS MAFK APOL5 MRPS16P3
GH22G035706 0.2 ENCODE 0.7 -2.3 -2336 0.2 APOL5 MRPS16P3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around APOL5 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the APOL5 gene promoter:

Genomic Location for APOL5 Gene

Chromosome:
22
Start:
35,708,424 bp from pter
End:
35,730,325 bp from pter
Size:
21,902 bases
Orientation:
Plus strand

Genomic View for APOL5 Gene

Genes around APOL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOL5 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for APOL5 Gene

Proteins for APOL5 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for APOL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWW9-APOL5_HUMAN
    Recommended name:
    Apolipoprotein L5
    Protein Accession:
    Q9BWW9
    Secondary Accessions:
    • Q5TFL9
    • Q9UGW5

    Protein attributes for APOL5 Gene

    Size:
    433 amino acids
    Molecular mass:
    47044 Da
    Quaternary structure:
    No Data Available

neXtProt entry for APOL5 Gene

Protein Expression for APOL5 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for APOL5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for APOL5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for APOL5 Gene

Domains & Families for APOL5 Gene

Gene Families for APOL5 Gene

HGNC:

Protein Domains for APOL5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for APOL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BWW9

UniProtKB/Swiss-Prot:

APOL5_HUMAN :
  • Belongs to the apolipoprotein L family.
Family:
  • Belongs to the apolipoprotein L family.
genes like me logo Genes that share domains with APOL5: view

Function for APOL5 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for APOL5 Gene

UniProtKB/Swiss-Prot Function:
May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.

Gene Ontology (GO) - Molecular Function for APOL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008035 high-density lipoprotein particle binding NAS 11374903
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with APOL5: view

Phenotypes for APOL5 Gene

GenomeRNAi human phenotypes for APOL5:
genes like me logo Genes that share phenotypes with APOL5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

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Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for APOL5 Gene

Localization for APOL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOL5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for APOL5 gene
Compartment Confidence
extracellular 2
cytosol 2
mitochondrion 1
peroxisome 1
nucleus 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for APOL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with APOL5: view

Pathways & Interactions for APOL5 Gene

genes like me logo Genes that share pathways with APOL5: view

Pathways by source for APOL5 Gene

Interacting Proteins for APOL5 Gene

Selected Interacting proteins: Q9BWW9-APOL5_HUMAN for APOL5 Gene via IID

Gene Ontology (GO) - Biological Process for APOL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process NAS 11374903
GO:0006810 transport IEA --
GO:0006869 lipid transport IEA --
GO:0042157 lipoprotein metabolic process IEA --
genes like me logo Genes that share ontologies with APOL5: view

No data available for SIGNOR curated interactions for APOL5 Gene

Drugs & Compounds for APOL5 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for APOL5 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for APOL5 Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for APOL5 Gene

Apolipoprotein L, 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for APOL5 Gene

No ASD Table

Relevant External Links for APOL5 Gene

GeneLoc Exon Structure for
APOL5
ECgene alternative splicing isoforms for
APOL5

Expression for APOL5 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for APOL5 Gene

mRNA expression in normal human tissues for APOL5 Gene
mRNA expression by BioGPS for APOL5 GenemRNA expression by GTEx for APOL5 Gene

mRNA differential expression in normal tissues according to GTEx for APOL5 Gene

This gene is overexpressed in Testis (x11.0), Liver (x8.6), and Muscle - Skeletal (x7.6).

Protein differential expression in normal tissues from HIPED for APOL5 Gene

This gene is overexpressed in Urine (44.2) and Adipocyte (24.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for APOL5 Gene



Protein tissue co-expression partners for APOL5 Gene

NURSA nuclear receptor signaling pathways regulating expression of APOL5 Gene:

APOL5

SOURCE GeneReport for Unigene cluster for APOL5 Gene:

Hs.326561

mRNA Expression by UniProt/SwissProt for APOL5 Gene:

Q9BWW9-APOL5_HUMAN
Tissue specificity: Low level of expression; detected in uterus, testis, skeletal muscle and stomach.
genes like me logo Genes that share expression patterns with APOL5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for APOL5 Gene

Orthologs for APOL5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia APOL5 35
  • 93 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia APOL5 34 35
  • 72.54 (n)
cow
(Bos Taurus)
 Mammalia -- 35
  • 37 (a)
 ManyToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 32 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Apol7a 35
  • 28 (a)
 ManyToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 35
  • 23 (a)
 ManyToMany
-- 35
  • 23 (a)
 ManyToMany
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 51 (a)
 ManyToMany
-- 35
  • 30 (a)
 ManyToMany
zebrafish
(Danio rerio)
 Actinopterygii APOL4 35
  • 13 (a)
 OneToMany
Species where no ortholog for APOL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APOL5 Gene

ENSEMBL:
Gene Tree for APOL5 (if available)
TreeFam:
Gene Tree for APOL5 (if available)

Paralogs for APOL5 Gene

Paralogs for APOL5 Gene

(2) SIMAP similar genes for APOL5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with APOL5: view

Variants for APOL5 Gene

Sequence variations from dbSNP and Humsavar for APOL5 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000023230 -- 35,727,774(+) GTGAT(A/G)AAAAC intron-variant
rs1000085795 -- 35,721,453(+) CAGGA(C/G)AATTG intron-variant
rs1000138979 -- 35,707,758(+) AGGCC(A/G)TAGAA upstream-variant-2KB
rs1000235641 -- 35,712,065(+) GCAGT(G/T)GTGCT intron-variant
rs1000301863 -- 35,716,966(+) AAATA(A/G)CTGGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for APOL5 Gene

Variant ID Type Subtype PubMed ID
nsv3612 CNV insertion 18451855
nsv511076 OTHER complex 20534489

Variation tolerance for APOL5 Gene

Residual Variation Intolerance Score: 83.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.01; 98.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for APOL5 Gene

Human Gene Mutation Database (HGMD)
APOL5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
APOL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOL5 Gene

Disorders for APOL5 Gene

Relevant External Links for APOL5

Genetic Association Database (GAD)
APOL5
Human Genome Epidemiology (HuGE) Navigator
APOL5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APOL5

No disorders were found for APOL5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APOL5 Gene

Publications for APOL5 Gene

  1. The human apolipoprotein L gene cluster: identification, classification, and sites of distribution. (PMID: 11374903) Page N.M. … Lowry P.J. (Genomics 2001) 2 3 4 64
  2. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) RuaA+o G. … Wu A.H. (Pharmacogenomics 2010) 3 46 64
  3. Genetic associations of brain structural networks in schizophrenia: a preliminary study. (PMID: 20691427) Jagannathan K. … Pearlson G.D. (Biol. Psychiatry 2010) 3 46 64
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4 64
  5. EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children. (PMID: 24348519) Namjou B. … Harley J.B. (Front Genet 2013) 3 64

Products for APOL5 Gene

Sources for APOL5 Gene

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