Aliases for APOL4 Gene
Aliases for APOL4 Gene
External Ids for APOL4 Gene
- HGNC: 14867
- Entrez Gene: 80832
- Ensembl: ENSG00000100336
- OMIM: 607254
- UniProtKB: Q9BPW4
Previous GeneCards Identifiers for APOL4 Gene
- GC22M033228
- GC22M034856
- GC22M034909
- GC22M036585
- GC22M019554
Summaries for APOL4 Gene
-
The protein encoded by this gene is a member of the apolipoprotein L family and may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Two transcript variants encoding two different isoforms have been found for this gene. Only one of the isoforms appears to be a secreted protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for APOL4 Gene
APOL4 (Apolipoprotein L4) is a Protein Coding gene. Diseases associated with APOL4 include Schizophrenia. Among its related pathways are Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF). GO annotations related to this gene include lipid binding. An important paralog of this gene is APOL3.
UniProtKB/Swiss-Prot for APOL4 Gene
-
May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity).
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOL4 Gene
Genomics for APOL4 Gene
Regulatory Elements for APOL4 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH22G036201 | 1.2 | Ensembl ENCODE | 39.3 | +1.7 | 1667 | 3.9 | HDAC1 HDGF ATF1 TBL1XR1 NFRKB RAD21 EGR1 SCRT2 REST ELF1 | APOL4 MTND1P10 |
| GH22G036196 | 1 | Ensembl ENCODE | 33.7 | +7.1 | 7128 | 3.4 | CTCF TFAP4 ZSCAN4 SALL2 BMI1 POLR2A ZNF207 ZNF548 EGR2 MAZ | APOL4 HMGXB4 RPS15AP38 MTND1P10 |
| GH22G036195 | 0.9 | Ensembl ENCODE | 15.2 | +9.6 | 9603 | 0.3 | CTCF ZNF654 TRIM22 REST THRB RAD21 NR2F2 ZNF143 ZNF207 SMC3 | APOL4 MTND1P10 |
| GH22G036236 | 1.3 | ENCODE dbSUPER | 7.1 | -33.8 | -33771 | 3.7 | HDGF FOXA2 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 | APOL4 ENSG00000273176 APOL2 |
| GH22G036208 | 0.6 | ENCODE | 14.5 | -4.5 | -4485 | 1.6 | SOX13 TFE3 ZMYM3 ZNF664 GATA3 TRIM24 MLLT1 HNF4A TRIM28 SETDB1 | APOL4 APOL2 |
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|---|---|---|
| ENSR00000145808 | 539 | 600 | HLF ZNF580 |
- Transcription factor binding sites by QIAGEN in the APOL4 gene promoter:
Regulatory Element Products
Genomic Location for APOL4 Gene
- Chromosome:
- 22
- Start:
- 36,189,124 bp from pter
- End:
- 36,204,840 bp from pter
- Size:
- 15,717 bases
- Orientation:
- Minus strand
Genomic View for APOL4 Gene
- Cytogenetic band:
-
- 22q12.3 by Ensembl
- 22q12.3 by Entrez Gene
- 22q12.3 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for APOL4 Gene
Proteins for APOL4 Gene
-
Protein details for APOL4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BPW4-APOL4_HUMAN
- Recommended name:
- Apolipoprotein L4
- Protein Accession:
- Q9BPW4
- Q9BQ37
- Q9BXQ8
Protein attributes for APOL4 Gene
- Size:
- 351 amino acids
- Molecular mass:
- 39164 Da
- Quaternary structure:
- No Data Available
Protein Expression for APOL4 Gene
Post-translational modifications for APOL4 Gene
Other Protein References for APOL4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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Custom Antibody ServicesOriGene Antibodies for APOL4
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-
Abcam antibodies for APOL4
- Invitrogen Antibodies for APOL4
- antibodies-online Antibodies for APOL4: See all 67
- GeneTex APOL4 antibody for APOL4
Protein Products
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- antibodies-online Proteins for APOL4: See all 4
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-
Abcam proteins for APOL4
Assay Products
- antibodies-online Kits for APOL4: See all 12
No data available for DME Specific Peptides for APOL4 Gene
Domains & Families for APOL4 Gene
Gene Families for APOL4 Gene
- HGNC:
Protein Domains for APOL4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for APOL4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BPW4- Family:
-
- Belongs to the apolipoprotein L family.
Function for APOL4 Gene
Molecular function for APOL4 Gene
- UniProtKB/Swiss-Prot Function:
- May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0005515 | protein binding | IPI | -- |
| GO:0008289 | lipid binding | IEA | -- |
Phenotypes for APOL4 Gene
- GenomeRNAi human phenotypes for APOL4:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for APOL4 gene
-
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CRISPR Products
-
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-
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miRNA for APOL4 Gene
- miRTarBase miRNAs that target APOL4
-
- hsa-mir-5572 (MIRT706801)
- hsa-mir-4260 (MIRT706802)
- hsa-mir-3912-5p (MIRT706803)
- hsa-mir-513b-5p (MIRT706804)
- hsa-mir-340-5p (MIRT706805)
- hsa-mir-4775 (MIRT706806)
- hsa-mir-8059 (MIRT706807)
- hsa-mir-4471 (MIRT706808)
- hsa-mir-6837-3p (MIRT706809)
- hsa-mir-6754-3p (MIRT706810)
- hsa-mir-412-3p (MIRT706811)
- hsa-mir-5092 (MIRT706812)
- hsa-mir-3163 (MIRT706813)
- hsa-mir-4496 (MIRT706814)
- hsa-mir-5583-5p (MIRT706815)
- hsa-mir-3129-3p (MIRT706816)
- hsa-mir-548l (MIRT706817)
- hsa-mir-548t-5p (MIRT706818)
- hsa-mir-548az-5p (MIRT706819)
- hsa-mir-548n (MIRT706820)
miRNA Products
- Search ViGene Biosciences for APOL4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for APOL4
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Clone Products
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- VectorBuilder custom plasmid, inducible vectors for APOL4
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for APOL4
-
ViGene Biosciences adenoviral particle packaged cDNA for APOL4 gene
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for APOL4 Gene
Localization for APOL4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for APOL4 Gene
- Secreted.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | ISS | 22261194 |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | -- |
Pathways & Interactions for APOL4 Gene
Pathways by source for APOL4 Gene
1 GeneGo (Thomson Reuters) pathway for APOL4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | NAS | 11944986 |
| GO:0006810 | transport | IEA | -- |
| GO:0006869 | lipid transport | IEA | -- |
| GO:0042157 | lipoprotein metabolic process | IEA | -- |
No data available for SIGNOR curated interactions for APOL4 Gene
Transcripts for APOL4 Gene
mRNA/cDNA for APOL4 Gene
- (2) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (77) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for APOL4
-
Santa Cruz Biotechnology (SCBT) CRISPR for APOL4
- GenScript: Design CRISPR guide RNA sequences for APOL4
miRNA Products
- Search ViGene Biosciences for APOL4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for APOL4
- Browse OriGene Inhibitory RNA Products For APOL4
-
ViGene Biosciences ready-to-package AAV shRNAs for APOL4 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for APOL4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APOL4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||
| SP6: |
Expression for APOL4 Gene
mRNA differential expression in normal tissues according to GTEx for APOL4 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for APOL4 Gene
NURSA nuclear receptor signaling pathways regulating expression of APOL4 Gene:
APOL4SOURCE GeneReport for Unigene cluster for APOL4 Gene:
Hs.115099mRNA Expression by UniProt/SwissProt for APOL4 Gene:
Q9BPW4-APOL4_HUMANEvidence on tissue expression from TISSUES for APOL4 Gene
- Pancreas(4.1)
Primer Products
-
OriGene qPCR primer pairs for APOL4
-
OriGene qPCR primer pairs and template standards for APOL4
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for APOL4 Gene
Orthologs for APOL4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | APOL3 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
ManyToMany | |
| mouse (Mus musculus) |
Mammalia | Apol9b 35 |
|
ManyToMany | |
| Apol9a 35 |
|
ManyToMany | |||
| Apol11a 35 |
|
ManyToMany | |||
| Apol10b 35 |
|
ManyToMany | |||
| Apol10a 35 |
|
ManyToMany | |||
| Apol11b 35 |
|
ManyToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| zebrafish (Danio rerio) |
Actinopterygii | APOL4 35 |
|
OneToMany |
- Species where no ortholog for APOL4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for APOL4 Gene
(3) SIMAP similar genes for APOL4 Gene using alignment to 11 proteins:
Variants for APOL4 Gene
| SNP ID | Clin | Chr 22 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000063742 | -- | 36,199,218(+) | GGTTC(C/T)GTTGG | intron-variant | |
| rs1000183277 | -- | 36,189,832(+) | GTAAC(C/T)CCTCC | utr-variant-3-prime | |
| rs1000213055 | -- | 36,194,598(+) | CATCT(C/G)ATTGA | intron-variant | |
| rs1000642938 | -- | 36,194,721(+) | TTCCA(G/T)CCTCT | intron-variant | |
| rs1000709853 | -- | 36,205,951(+) | CCCCT(C/G/T)AATGG | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3647680 | CNV | loss | 21293372 |
| esv7844 | OTHER | inversion | 19470904 |
| nsv1129335 | OTHER | inversion | 24896259 |
Relevant External Links for APOL4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- APOL4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOL4 Gene
Disorders for APOL4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| schizophrenia |
|
|
Relevant External Links for APOL4
No data available for UniProtKB/Swiss-Prot and Genatlas for APOL4 Gene
Publications for APOL4 Gene
- The human apolipoprotein L gene cluster: identification, classification, and sites of distribution. (PMID: 11374903) Page N.M. … Lowry P.J. (Genomics 2001) 2 3 4 64
- Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene. (PMID: 11290834) Duchateau P.N. … Kane J.P. (J. Lipid Res. 2001) 3 4 22 64
- Association of SNPs and haplotypes in APOL1, 2 and 4 with schizophrenia. (PMID: 18632255) Takahashi S. … Tsuang M.T. (Schizophr. Res. 2008) 3 46 64
- Investigation of the apolipoprotein-L (APOL) gene family and schizophrenia using a novel DNA pooling strategy for public database SNPs. (PMID: 15949655) McGhee K.A. … Corvin A. (Schizophr. Res. 2005) 3 46 64
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
Products for APOL4 Gene
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- Novus Biologicals Antibodies for APOL4
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- Novus Biologicals
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- Abcam antibodies for APOL4
- Abcam proteins for APOL4
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- ProSpec Recombinant Proteins for APOL4
- antibodies-online Antibodies for APOL4: See all 67
- antibodies-online Kits for APOL4: See all 12
- antibodies-online Proteins for APOL4: See all 4
- Search antibodies-online for peptides
- GeneTex APOL4 antibody for APOL4
- Search GeneTex for Proteins for APOL4
- ViGene Biosciences adenoviral particle packaged cDNA for APOL4 gene
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- Search ViGene Biosciences for APOL4
- Horizon Cell Lines for APOL4
- Cyagen custom Knockout/knockin (KOKI) mouse models for APOL4
- VectorBuilder custom plasmid, inducible vectors for APOL4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APOL4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for APOL4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
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- (122) diseasecard
- (123) NIH Rare Diseases
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- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
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- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
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- (140) FANTOM5
- (141) ENCODE
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- (143) Horizon
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- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




