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Aliases for APOL4 Gene

Aliases for APOL4 Gene

  • Apolipoprotein L, 4 2 3
  • Apolipoprotein L-IV 3 4
  • APOL-IV 3 4
  • Apolipoprotein L4 3
  • APOLIV 3

External Ids for APOL4 Gene

Previous GeneCards Identifiers for APOL4 Gene

  • GC22M033228
  • GC22M034856
  • GC22M034909
  • GC22M036585
  • GC22M019554

Summaries for APOL4 Gene

Entrez Gene Summary for APOL4 Gene

  • The protein encoded by this gene is a member of the apolipoprotein L family and may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Two transcript variants encoding two different isoforms have been found for this gene. Only one of the isoforms appears to be a secreted protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOL4 Gene

APOL4 (Apolipoprotein L, 4) is a Protein Coding gene. Diseases associated with APOL4 include schizophrenia. Among its related pathways are Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF). GO annotations related to this gene include lipid binding. An important paralog of this gene is APOL5.

UniProtKB/Swiss-Prot for APOL4 Gene

  • May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOL4 Gene

Genomics for APOL4 Gene

Regulatory Elements for APOL4 Gene

Genomic Location for APOL4 Gene

Start:
36,189,124 bp from pter
End:
36,204,840 bp from pter
Size:
15,717 bases
Orientation:
Minus strand

Genomic View for APOL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APOL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOL4 Gene

Proteins for APOL4 Gene

  • Protein details for APOL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BPW4-APOL4_HUMAN
    Recommended name:
    Apolipoprotein L4
    Protein Accession:
    Q9BPW4
    Secondary Accessions:
    • Q9BQ37
    • Q9BXQ8

    Protein attributes for APOL4 Gene

    Size:
    351 amino acids
    Molecular mass:
    39164 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for APOL4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for APOL4 Gene

Proteomics data for APOL4 Gene at MOPED

Post-translational modifications for APOL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for APOL4 Gene

Domains for APOL4 Gene

Gene Families for APOL4 Gene

HGNC:

Protein Domains for APOL4 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9BPW4

UniProtKB/Swiss-Prot:

APOL4_HUMAN :
  • Q9BPW4
Family:
  • Belongs to the apolipoprotein L family.
genes like me logo Genes that share domains with APOL4: view

Function for APOL4 Gene

Molecular function for APOL4 Gene

UniProtKB/Swiss-Prot Function: May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity).

Gene Ontology (GO) - Molecular Function for APOL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with APOL4: view

Phenotypes for APOL4 Gene

GenomeRNAi human phenotypes for APOL4:
genes like me logo Genes that share phenotypes with APOL4: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APOL4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for APOL4 Gene

Localization for APOL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOL4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOL4 Gene COMPARTMENTS Subcellular localization image for APOL4 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 2
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for APOL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region --
GO:0005615 extracellular space ISS 22261194
genes like me logo Genes that share ontologies with APOL4: view

Pathways for APOL4 Gene

genes like me logo Genes that share pathways with APOL4: view

Pathways by source for APOL4 Gene

Interacting Proteins for APOL4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000338260%0d%0a9606.ENSP00000201031%0d%0a9606.ENSP00000263925%0d%0a
Selected Interacting proteins: ENSP00000338260 for APOL4 Gene via STRING

Gene Ontology (GO) - Biological Process for APOL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process NAS 11944986
GO:0006869 lipid transport IEA --
GO:0042157 lipoprotein metabolic process IEA --
genes like me logo Genes that share ontologies with APOL4: view

Transcripts for APOL4 Gene

Unigene Clusters for APOL4 Gene

Apolipoprotein L, 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APOL4

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for APOL4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c
SP1: -
SP2: - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - -
SP6:

Relevant External Links for APOL4 Gene

GeneLoc Exon Structure for
APOL4
ECgene alternative splicing isoforms for
APOL4

Expression for APOL4 Gene

mRNA expression in normal human tissues for APOL4 Gene

mRNA differential expression in normal tissues according to GTEx for APOL4 Gene

This gene is overexpressed in Pituitary (5.1) and Adipose - Visceral (Omentum) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for APOL4 Gene

SOURCE GeneReport for Unigene cluster for APOL4 Gene Hs.115099

mRNA Expression by UniProt/SwissProt for APOL4 Gene

Q9BPW4-APOL4_HUMAN
Tissue specificity: Widely expressed; the highest levels are in spinal cord, placenta, adrenal gland; also detected in spleen, bone marrow, uterus, trachea, mammary gland and testis; levels are low in brain, heart and pancreas
genes like me logo Genes that share expressions with APOL4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for APOL4 Gene

Orthologs for APOL4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOL4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 38 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
APOL3 36
  • 40 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 36 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Apol10a 36
  • 27 (a)
ManyToMany
Apol10b 36
  • 30 (a)
ManyToMany
Apol11a 36
  • 32 (a)
ManyToMany
Apol11b 36
  • 26 (a)
ManyToMany
Apol7b 16
Apol9a 36
  • 33 (a)
ManyToMany
Apol9b 36
  • 34 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 20 (a)
ManyToMany
-- 36
  • 20 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 26 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 26 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii APOL4 36
  • 11 (a)
OneToMany
Species with no ortholog for APOL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APOL4 Gene

ENSEMBL:
Gene Tree for APOL4 (if available)
TreeFam:
Gene Tree for APOL4 (if available)

Paralogs for APOL4 Gene

Paralogs for APOL4 Gene

genes like me logo Genes that share paralogs with APOL4: view

Variants for APOL4 Gene

Sequence variations from dbSNP and Humsavar for APOL4 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs12781 -- 36,189,194(+) GATCC(A/G)GCCTC utr-variant-3-prime
rs80587 - 36,202,003(+) GCAGA(C/G)GACAA utr-variant-5-prime, missense, reference
rs132697 -- 36,188,665(+) TATCA(A/G)CACAC downstream-variant-500B
rs132698 -- 36,190,300(+) cagga(A/C)cacag utr-variant-3-prime
rs132699 -- 36,190,890(+) gtgat(A/C)agtgt utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for APOL4 Gene

Variant ID Type Subtype PubMed ID
nsv915006 CNV Loss 21882294
esv7844 OTHER Inversion 19470904

Relevant External Links for APOL4 Gene

HapMap Linkage Disequilibrium report
APOL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOL4 Gene

Disorders for APOL4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for APOL4 Gene including...

Search for APOL4 Gene in MalaCards »

(1) OMIM Diseases for APOL4 Gene (607254)

Relevant External Links for APOL4

Genetic Association Database (GAD)
APOL4
Human Genome Epidemiology (HuGE) Navigator
APOL4
genes like me logo Genes that share disorders with APOL4: view

No data available for UniProtKB/Swiss-Prot for APOL4 Gene

Publications for APOL4 Gene

  1. The human apolipoprotein L gene cluster: identification, classification, and sites of distribution. (PMID: 11374903) Page N.M. … Lowry P.J. (Genomics 2001) 2 3 4
  2. Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene. (PMID: 11290834) Duchateau P.N. … Kane J.P. (J. Lipid Res. 2001) 3 4 23
  3. Investigation of the apolipoprotein-L (APOL) gene family and schizophrenia using a novel DNA pooling strategy for public database SNPs. (PMID: 15949655) McGhee K.A. … Corvin A. (Schizophr. Res. 2005) 3 48
  4. Association of SNPs and haplotypes in APOL1, 2 and 4 with schizophrenia. (PMID: 18632255) Takahashi S. … Tsuang M.T. (Schizophr. Res. 2008) 3 48
  5. Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. (PMID: 22261194) Barallobre-Barreiro J. … Mayr M. (Circulation 2012) 3

Products for APOL4 Gene

Sources for APOL4 Gene

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