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Aliases for APOL4 Gene

Aliases for APOL4 Gene

  • Apolipoprotein L4 2 3 5
  • Apolipoprotein L-IV 3 4
  • APOL-IV 3 4
  • Apolipoprotein L, 4 3
  • APOLIV 3

External Ids for APOL4 Gene

Previous GeneCards Identifiers for APOL4 Gene

  • GC22M033228
  • GC22M034856
  • GC22M034909
  • GC22M036585
  • GC22M019554

Summaries for APOL4 Gene

Entrez Gene Summary for APOL4 Gene

  • The protein encoded by this gene is a member of the apolipoprotein L family and may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Two transcript variants encoding two different isoforms have been found for this gene. Only one of the isoforms appears to be a secreted protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOL4 Gene

APOL4 (Apolipoprotein L4) is a Protein Coding gene. Diseases associated with APOL4 include Schizophrenia. Among its related pathways are Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF). GO annotations related to this gene include lipid binding. An important paralog of this gene is APOL3.

UniProtKB/Swiss-Prot for APOL4 Gene

  • May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOL4 Gene

Genomics for APOL4 Gene

Regulatory Elements for APOL4 Gene

Enhancers for APOL4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F036195 1.1 Ensembl ENCODE 33.7 +7.6 7591 4.4 CTCF TFAP4 BMI1 THRB RAD21 POLR2A ZNF143 ZNF207 SMC3 ZNF548 APOL4 HMGXB4 RPS15AP38 MTND1P10
GH22F036201 0.9 ENCODE 39.4 +1.6 1637 3.9 HDAC1 TBL1XR1 RAD21 SCRT2 REST SMARCA4 IKZF1 ZNF580 HMBOX1 KDM1A APOL4 MTND1P10
GH22F036205 0.6 FANTOM5 Ensembl 27.3 -1.4 -1361 0.8 APOL4 APOL3 APOL2 APOL1
GH22F036208 0.9 Ensembl ENCODE 14.5 -4.4 -4415 1.7 SOX13 TFE3 ZMYM3 ZNF664 GATA3 TRIM24 MLLT1 SETDB1 TRIM28 APOL4 APOL2
GH22F036191 0.5 ENCODE 16.4 +13.2 13227 1.0 ZNF316 EMSY MAFK APOL4 APOL3 ENSG00000252225 MTND1P10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around APOL4 on UCSC Golden Path with GeneCards custom track

Promoters for APOL4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001843342 440 801 CTCF HLF ZNF580 REST

Genomic Location for APOL4 Gene

Chromosome:
22
Start:
36,189,124 bp from pter
End:
36,204,840 bp from pter
Size:
15,717 bases
Orientation:
Minus strand

Genomic View for APOL4 Gene

Genes around APOL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOL4 Gene

Proteins for APOL4 Gene

  • Protein details for APOL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BPW4-APOL4_HUMAN
    Recommended name:
    Apolipoprotein L4
    Protein Accession:
    Q9BPW4
    Secondary Accessions:
    • Q9BQ37
    • Q9BXQ8

    Protein attributes for APOL4 Gene

    Size:
    351 amino acids
    Molecular mass:
    39164 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for APOL4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for APOL4 Gene

Post-translational modifications for APOL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for APOL4 Gene

Domains & Families for APOL4 Gene

Gene Families for APOL4 Gene

Protein Domains for APOL4 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9BPW4

UniProtKB/Swiss-Prot:

APOL4_HUMAN :
  • Belongs to the apolipoprotein L family.
Family:
  • Belongs to the apolipoprotein L family.
genes like me logo Genes that share domains with APOL4: view

Function for APOL4 Gene

Molecular function for APOL4 Gene

UniProtKB/Swiss-Prot Function:
May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity).

Gene Ontology (GO) - Molecular Function for APOL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with APOL4: view
genes like me logo Genes that share phenotypes with APOL4: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for APOL4 Gene

Localization for APOL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOL4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for APOL4 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 2
plasma membrane 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for APOL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space ISS 22261194
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with APOL4: view

Pathways & Interactions for APOL4 Gene

genes like me logo Genes that share pathways with APOL4: view

Pathways by source for APOL4 Gene

Interacting Proteins for APOL4 Gene

Gene Ontology (GO) - Biological Process for APOL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process NAS 11944986
GO:0006810 transport IEA --
GO:0006869 lipid transport IEA --
GO:0042157 lipoprotein metabolic process IEA --
genes like me logo Genes that share ontologies with APOL4: view

No data available for SIGNOR curated interactions for APOL4 Gene

Transcripts for APOL4 Gene

Unigene Clusters for APOL4 Gene

Apolipoprotein L, 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for APOL4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c
SP1: -
SP2: - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - -
SP6:

Relevant External Links for APOL4 Gene

GeneLoc Exon Structure for
APOL4
ECgene alternative splicing isoforms for
APOL4

Expression for APOL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for APOL4 Gene

mRNA differential expression in normal tissues according to GTEx for APOL4 Gene

This gene is overexpressed in Pituitary (x5.1) and Adipose - Visceral (Omentum) (x4.2).

Protein differential expression in normal tissues from HIPED for APOL4 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for APOL4 Gene



Protein tissue co-expression partners for APOL4 Gene

NURSA nuclear receptor signaling pathways regulating expression of APOL4 Gene:

APOL4

SOURCE GeneReport for Unigene cluster for APOL4 Gene:

Hs.115099

mRNA Expression by UniProt/SwissProt for APOL4 Gene:

Q9BPW4-APOL4_HUMAN
Tissue specificity: Widely expressed; the highest levels are in spinal cord, placenta, adrenal gland; also detected in spleen, bone marrow, uterus, trachea, mammary gland and testis; levels are low in brain, heart and pancreas.
genes like me logo Genes that share expression patterns with APOL4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for APOL4 Gene

Orthologs for APOL4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOL4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia APOL3 35
  • 40 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 36 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Apol9b 35
  • 34 (a)
ManyToMany
Apol9a 35
  • 33 (a)
ManyToMany
Apol11a 35
  • 32 (a)
ManyToMany
Apol10b 35
  • 30 (a)
ManyToMany
Apol10a 35
  • 27 (a)
ManyToMany
Apol11b 35
  • 26 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 26 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 20 (a)
ManyToMany
-- 35
  • 20 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 42 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii APOL4 35
  • 11 (a)
OneToMany
Species where no ortholog for APOL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APOL4 Gene

ENSEMBL:
Gene Tree for APOL4 (if available)
TreeFam:
Gene Tree for APOL4 (if available)

Paralogs for APOL4 Gene

Paralogs for APOL4 Gene

genes like me logo Genes that share paralogs with APOL4: view

Variants for APOL4 Gene

Sequence variations from dbSNP and Humsavar for APOL4 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1053982 -- 36,189,516(-) CTCTC(A/G)CCCTG utr-variant-3-prime
rs1053983 -- 36,189,478(-) CTCCC(A/G)GGGGT utr-variant-3-prime
rs111781032 -- 36,191,106(+) TATGG(G/T)TGAGC reference, missense
rs111906543 -- 36,200,688(+) GGGTA(G/T)CAACA intron-variant
rs111948780 -- 36,193,555(+) AGTTA(C/T)CAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for APOL4 Gene

Variant ID Type Subtype PubMed ID
nsv1129335 OTHER inversion 24896259
esv7844 OTHER inversion 19470904
esv3647680 CNV loss 21293372

Variation tolerance for APOL4 Gene

Gene Damage Index Score: 4.19; 61.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for APOL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
APOL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOL4 Gene

Disorders for APOL4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for APOL4 Gene - From: OMIM and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search APOL4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for APOL4

Genetic Association Database (GAD)
APOL4
Human Genome Epidemiology (HuGE) Navigator
APOL4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APOL4
genes like me logo Genes that share disorders with APOL4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for APOL4 Gene

Publications for APOL4 Gene

  1. The human apolipoprotein L gene cluster: identification, classification, and sites of distribution. (PMID: 11374903) Page N.M. … Lowry P.J. (Genomics 2001) 2 3 4 64
  2. Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene. (PMID: 11290834) Duchateau P.N. … Kane J.P. (J. Lipid Res. 2001) 3 4 22 64
  3. Association of SNPs and haplotypes in APOL1, 2 and 4 with schizophrenia. (PMID: 18632255) Takahashi S. … Tsuang M.T. (Schizophr. Res. 2008) 3 46 64
  4. Investigation of the apolipoprotein-L (APOL) gene family and schizophrenia using a novel DNA pooling strategy for public database SNPs. (PMID: 15949655) McGhee K.A. … Corvin A. (Schizophr. Res. 2005) 3 46 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for APOL4 Gene

Sources for APOL4 Gene

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