Free for academic non-profit institutions. Other users need a Commercial license

Aliases for APOL4 Gene

Aliases for APOL4 Gene

  • Apolipoprotein L, 4 2 3
  • Apolipoprotein L-IV 3 4
  • APOL-IV 3 4
  • Apolipoprotein L4 3
  • APOLIV 3

External Ids for APOL4 Gene

Summaries for APOL4 Gene

Entrez Gene Summary for APOL4 Gene

  • The protein encoded by this gene is a member of the apolipoprotein L family and may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Two transcript variants encoding two different isoforms have been found for this gene. Only one of the isoforms appears to be a secreted protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOL4 Gene

APOL4 (Apolipoprotein L, 4) is a Protein Coding gene. Diseases associated with APOL4 include schizophrenia. Among its related pathways are Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF). GO annotations related to this gene include lipid binding. An important paralog of this gene is APOL5.

UniProtKB/Swiss-Prot for APOL4 Gene

  • May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOL4 Gene

Genomics for APOL4 Gene

Genomic Location for APOL4 Gene

36,189,124 bp from pter
36,204,840 bp from pter
15,717 bases
Minus strand

Genomic View for APOL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APOL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOL4 Gene

Regulatory Elements for APOL4 Gene

Proteins for APOL4 Gene

  • Protein details for APOL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Apolipoprotein L4
    Protein Accession:
    Secondary Accessions:
    • Q9BQ37
    • Q9BXQ8

    Protein attributes for APOL4 Gene

    351 amino acids
    Molecular mass:
    39164 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for APOL4 Gene


neXtProt entry for APOL4 Gene

Proteomics data for APOL4 Gene at MOPED

Post-translational modifications for APOL4 Gene

No Post-translational modifications

No data available for DME Specific Peptides for APOL4 Gene

Domains for APOL4 Gene

Gene Families for APOL4 Gene


Protein Domains for APOL4 Gene



  • Belongs to the apolipoprotein L family.:
    • Q9BPW4
genes like me logo Genes that share domains with APOL4: view

Function for APOL4 Gene

Molecular function for APOL4 Gene

UniProtKB/Swiss-Prot Function: May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity).

Gene Ontology (GO) - Molecular Function for APOL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with APOL4: view

Phenotypes for APOL4 Gene

GenomeRNAi human phenotypes for APOL4:
genes like me logo Genes that share phenotypes with APOL4: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for APOL4 Gene

Localization for APOL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOL4 Gene


Subcellular locations from

Jensen Localization Image for APOL4 Gene COMPARTMENTS Subcellular localization image for APOL4 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 2
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for APOL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region --
GO:0005615 extracellular space ISS 22261194
genes like me logo Genes that share ontologies with APOL4: view

Pathways for APOL4 Gene

genes like me logo Genes that share pathways with APOL4: view

Pathways by source for APOL4 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for APOL4 Gene

Interacting Proteins for APOL4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000338260 for APOL4 Gene via STRING

Gene Ontology (GO) - Biological Process for APOL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process NAS 11944986
GO:0006869 lipid transport IEA --
GO:0042157 lipoprotein metabolic process IEA --
genes like me logo Genes that share ontologies with APOL4: view

Transcripts for APOL4 Gene

Unigene Clusters for APOL4 Gene

Apolipoprotein L, 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APOL4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c
SP1: -
SP2: - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - -

Relevant External Links for APOL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for APOL4 Gene

mRNA expression in normal human tissues for APOL4 Gene

mRNA differential expression in normal tissues according to GTEx for APOL4 Gene

This gene is overexpressed in Pituitary (5.1) and Adipose - Visceral (Omentum) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for APOL4 Gene

SOURCE GeneReport for Unigene cluster for APOL4 Gene Hs.115099

mRNA Expression by UniProt/SwissProt for APOL4 Gene

Tissue specificity: Widely expressed; the highest levels are in spinal cord, placenta, adrenal gland; also detected in spleen, bone marrow, uterus, trachea, mammary gland and testis; levels are low in brain, heart and pancreas
genes like me logo Genes that share expressions with APOL4: view

Orthologs for APOL4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 37
  • 38 (a)
-- 37
  • 32 (a)
APOL3 37
  • 40 (a)
(Canis familiaris)
Mammalia -- 37
  • 36 (a)
(Mus musculus)
Mammalia Apol10a 37
  • 27 (a)
Apol10b 37
  • 30 (a)
Apol11a 37
  • 32 (a)
Apol11b 37
  • 26 (a)
Apol7b 16
Apol9a 37
  • 33 (a)
Apol9b 37
  • 34 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 20 (a)
-- 37
  • 20 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 26 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 26 (a)
-- 37
  • 42 (a)
(Danio rerio)
Actinopterygii APOL4 37
  • 11 (a)
Species with no ortholog for APOL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APOL4 Gene

Gene Tree for APOL4 (if available)
Gene Tree for APOL4 (if available)

Paralogs for APOL4 Gene

Paralogs for APOL4 Gene

genes like me logo Genes that share paralogs with APOL4: view

Variants for APOL4 Gene

Sequence variations from dbSNP and Humsavar for APOL4 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs12781 -- 36,189,194(+) GATCC(A/G)GCCTC utr-variant-3-prime
rs80587 - 36,202,003(+) GCAGA(C/G)GACAA utr-variant-5-prime, missense, reference
rs132697 -- 36,188,665(+) TATCA(A/G)CACAC downstream-variant-500B
rs132698 -- 36,190,300(+) cagga(A/C)cacag utr-variant-3-prime
rs132699 -- 36,190,890(+) gtgat(A/C)agtgt utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for APOL4 Gene

Variant ID Type Subtype PubMed ID
nsv915006 CNV Loss 21882294
esv7844 OTHER Inversion 19470904

Relevant External Links for APOL4 Gene

HapMap Linkage Disequilibrium report

Disorders for APOL4 Gene

(1) OMIM Diseases for APOL4 Gene (607254)

(1) MalaCards Diseases for APOL4 Gene

Search for APOL4 Gene in MalaCards »

Relevant External Links for APOL4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with APOL4: view

No data available for UniProtKB/Swiss-Prot for APOL4 Gene

Publications for APOL4 Gene

  1. The human apolipoprotein L gene cluster: identification, classification, and sites of distribution. (PMID: 11374903) Page N.M. … Lowry P.J. (Genomics 2001) 2 3 4
  2. Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene. (PMID: 11290834) Duchateau P.N. … Kane J.P. (J. Lipid Res. 2001) 3 4 23
  3. Investigation of the apolipoprotein-L (APOL) gene family and schizophrenia using a novel DNA pooling strategy for public database SNPs. (PMID: 15949655) McGhee K.A. … Corvin A. (Schizophr. Res. 2005) 3 49
  4. Association of SNPs and haplotypes in APOL1, 2 and 4 with schizophrenia. (PMID: 18632255) Takahashi S. … Tsuang M.T. (Schizophr. Res. 2008) 3 49
  5. Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. (PMID: 22261194) Barallobre-Barreiro J. … Mayr M. (Circulation 2012) 3

Products for APOL4 Gene

Sources for APOL4 Gene

Back to Top