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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

APOL4 Gene

protein-coding   GIFtS: 51
GCID: GC22M036585

Apolipoprotein L, 4

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Apolipoprotein L, 41 2
Apolipoprotein L-IV2 3
APOL-IV2
APOLIV2
Apolipoprotein L42
ApoL-IV3

External Ids:    HGNC: 148671   Entrez Gene: 808322   Ensembl: ENSG000001003367   OMIM: 6072545   UniProtKB: Q9BPW43   

Export aliases for APOL4 gene to outside databases

Previous GC identifers: GC22M033228 GC22M034856 GC22M034909 GC22M019554


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for APOL4 Gene:
The protein encoded by this gene is a member of the apolipoprotein L family and may play a role in lipid exchange
and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the
liver. Two transcript variants encoding two different isoforms have been found for this gene. Only one of the
isoforms appears to be a secreted protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for APOL4 Gene: 
APOL4 (apolipoprotein L, 4) is a protein-coding gene. Diseases associated with APOL4 include schizophrenia. GO annotations related to this gene include lipid binding and molecular_function. An important paralog of this gene is APOL6.

UniProtKB/Swiss-Prot: APOL4_HUMAN, Q9BPW4
Function: May play a role in lipid exchange and transport throughout the body. May participate in reverse
cholesterol transport from peripheral cells to the liver (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the APOL4 gene promoter:
         IRF-2   ISGF-3   IRF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): APOL4 promoter sequence
   Search SABiosciences Chromatin IP Primers for APOL4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.2-q13.2   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q11.2-q13.2

APOL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOL4 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M036585:  view genomic region     (about GC identifiers)

Start:
36,585,172 bp from pter      End:
36,600,886 bp from pter
Size:
15,715 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: APOL4_HUMAN, Q9BPW4 (See protein sequence)
Recommended Name: Apolipoprotein L4 precursor  
Size: 351 amino acids; 39164 Da
Subcellular location: Secreted (Potential)
Secondary accessions: Q9BQ37 Q9BXQ8
Alternative splicing: 3 isoforms:  Q9BPW4-1   Q9BPW4-2   Q9BPW4-3   

Explore the universe of human proteins at neXtProt for APOL4: NX_Q9BPW4

Explore proteomics data for APOL4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BPW4

  • APOL4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    APOL4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_085146.2  NP_663693.1  

    ENSEMBL proteins: 
     ENSP00000385119   ENSP00000384011   ENSP00000404366   ENSP00000432133   ENSP00000409085  
     ENSP00000395548   ENSP00000388936   ENSP00000380445   ENSP00000393096   ENSP00000338260  
     ENSP00000333229   ENSP00000331089  

    Human Recombinant Protein Products for APOL4: 
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    Novus Biologicals APOL4 Proteins
    Novus Biologicals APOL4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for APOL4 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005576extracellular region ----
    GO:0005615extracellular space ISS--

    APOL4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    APOLIPO: Apolipoproteins

    1 InterPro protein domain:
     IPR008405 ApoL

    Graphical View of Domain Structure for InterPro Entry Q9BPW4

    ProtoNet protein and cluster: Q9BPW4

    1 Blocks protein domain: IPB008405 Apolipoprotein L

    UniProtKB/Swiss-Prot: APOL4_HUMAN, Q9BPW4
    Similarity: Belongs to the apolipoprotein L family


    APOL4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APOL4_HUMAN, Q9BPW4
    Function: May play a role in lipid exchange and transport throughout the body. May participate in reverse
    cholesterol transport from peripheral cells to the liver (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0008289lipid binding IEA--
         
    APOL4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for APOL4:
     Decreased nuclei size in G2M 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for APOL4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for APOL4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for APOL4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for APOL4 

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    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for APOL4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF)
    Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for APOL4
        Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF)


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for APOL4

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process NAS11944986
    GO:0006869lipid transport IEA--
    GO:0042157lipoprotein metabolic process IEA--

    APOL4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for APOL4

    Search CenterWatch for drugs/clinical trials and news about APOL4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for APOL4 gene (2 alternative transcripts): 
    NM_030643.4  NM_145660.2  

    Unigene Cluster for APOL4:

    Apolipoprotein L, 4
    Hs.115099  [show with all ESTs]
    Unigene Representative Sequence: AY014914
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000479929 ENST00000404685(uc003aox.3) ENST00000405511(uc003aow.3 uc010gww.3)
    ENST00000429038 ENST00000524531 ENST00000493203 ENST00000457630 ENST00000419360
    ENST00000449084 ENST00000397275(uc003aoy.3) ENST00000436763 ENST00000480236
    ENST00000352371 ENST00000332987 ENST00000328429
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APOL4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate APOL4
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    Inhib. RNA
    Products:
         
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APOL4
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                         Customized lentivirus expression plasmids for stable overexpression of APOL4 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APOL4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APOL4

    Additional mRNA sequence: 

    AF305226.1 AK225696.1 AK290466.1 AK290777.1 AK311506.1 AK312716.1 AK313637.1 AY014914.1 
    AY014915.1 BC004150.2 BC006276.2 BC010131.2 BC017313.2 CR456380.1 

    5 DOTS entries:

    DT.75177220  DT.100777137  DT.92414720  DT.120643123  DT.99939503 

    24/77 AceView cDNA sequences (see all 77):

    BE900392 NM_030643 AA974092 BC010131 BC017313 CR607178 NM_145660 BC006276 
    AF305226 BE900719 AW151446 AA774194 BG941675 AI168715 BM194654 AI131026 
    AA025373 AI669093 AL601336 BI914645 AI057161 BX283290 BC004150 BE731647 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for APOL4 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c
    SP1:                                            -                                                         
    SP2:                                            -     -           -                                       
    SP3:                                -     -     -     -           -                 -                     
    SP4:                                            -     -           -                 -                     
    SP5:                                            -     -           -                                       


    ECgene alternative splicing isoforms for APOL4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    APOL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    APOL4 Expression
    About this image


    See APOL4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for APOL4

    SOURCE GeneReport for Unigene cluster: Hs.115099

    UniProtKB/Swiss-Prot: APOL4_HUMAN, Q9BPW4
    Tissue specificity: Widely expressed; the highest levels are in spinal cord, placenta, adrenal gland; also
    detected in spleen, bone marrow, uterus, trachea, mammary gland and testis; levels are low in brain, heart and
    pancreas

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOL4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for APOL4 gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Apol7b1 , 5 apolipoprotein L 7b1, 5 58.07(n)1
    38.68(a)1
      15 (36.40 cM)5
    2786791  NM_001024848.21  NP_001020019.21 
     774222105 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    42(a)
    26(a)
    many ↔ many
    many ↔ many
    5(21779188-21779424)
    5(21745647-21750643)
    zebrafish
    (Danio rerio)
    Actinopterygii APOL26
    apolipoprotein L, 2
    13(a)
    1 → many
    3(29825427-29839518)


    ENSEMBL Gene Tree for APOL4 (if available)
    TreeFam Gene Tree for APOL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for APOL4 gene
    APOL31 2  APOL62  APOL22  APOL52  APOL12  
    3 SIMAP similar genes for APOL4 using alignment to 11 protein entries:     APOL4_HUMAN (see all proteins):
    APOL3    APOL2    APOL1

    APOL4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/595 SNPs in APOL4 are shown (see all 595)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs628113621,2
    C--19565654(+) AGCAT-/GTCACC 2 -- int10--------
    rs1819781571,2
    --20506124(+) TCAGGC/TACCCA 2 -- ds50010--------
    rs1326971,2
    C,F,A,H--20506154(+) TATCAG/ACACAC 2 -- ds500125Minor allele frequency- A:0.12NS EA NA WA CSA 2330
    rs121591751,2
    C,H--20506199(+) CAAGTC/TTCTAG 2 -- ds50014Minor allele frequency- T:0.00NS EA 420
    rs1159935991,2
    C,F--20506316(+) CAGGCT/CGGTTC 2 -- ds50011Minor allele frequency- C:0.01WA 118
    rs81360641,2
    C,F,H--20506387(+) TTTTCT/GTCACA 2 -- ds500115Minor allele frequency- G:0.04NS EA NA WA 2212
    rs57502361,2
    C,F,A--20506603(+) TGACTC/TAAACA 2 -- ds50018Minor allele frequency- T:0.30NA WA CSA EA 367
    rs1383506331,2
    C--20506673(+) CAGCTC/TGAGAG 2 -- ut310--------
    rs127811,2
    C,F,A,H--20506683(+) GATCCG/AGCCTC 2 -- ut3195Minor allele frequency- A:0.25MN NS EA NA PA EU CA WA CSA 4819
    rs412832071,2
    C--20506812(+) GACACC/TTGGTC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for APOL4 (36585172 - 36600886 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for APOL4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv915006CNV Loss21882294
    esv7844OTHER Inversion19470904

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing APOL4
    DNA2.0 Custom Variant and Variant Library Synthesis for APOL4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607254   
    OMIM disorders: 181500  
    2 diseases for APOL4:    About MalaCards
    schizophrenia    


    APOL4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): APOL4
    Human Genome Epidemiology (HuGE) Navigator: APOL4 (2 documents)

    Export disorders for APOL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for APOL4 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with APOL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human apolipoprotein L gene cluster: identification, classification, and sites of distribution. (PubMed id 11374903)1, 2, 3 Page N.M....Lowry P.J. (2001)
    2. Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene. (PubMed id 11290834)1, 2, 9 Duchateau P.N.... Kane J.P. (2001)
    3. Association of SNPs and haplotypes in APOL1, 2 and 4 with schizophrenia. (PubMed id 18632255)1, 4 Takahashi S....Tsuang M.T. (2008)
    4. Investigation of the apolipoprotein-L (APOL) gene family and schizophrenia using a novel DNA pooling strategy for public database SNPs. (PubMed id 15949655)1, 4 McGhee K.A....Corvin A. (2005)
    5. Candidate genes for non-diabetic ESRD in African Amer icans: a genome-wide association study using pooled DNA. (PubMed id 20532800)4 Bostrom M.A....Freedman B.I. (2010)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1 Collins J.E.... Dunham I. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue. (PubMed id 11944986)1 Monajemi H.... Horrevoets A.J.G. (2002)
    10. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80832 HGNC: 14867 AceView: APOL4 Ensembl:ENSG00000100336 euGenes: HUgn80832
    ECgene: APOL4 H-InvDB: APOL4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for APOL4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for APOL4 gene:
    Search GeneIP for patents involving APOL4

    GeneCards and IP:
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