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APOL3 Gene

protein-coding   GIFtS: 56
GCID: GC22M036536

Apolipoprotein L, 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Apolipoprotein L, 31 2     CG1212
Apolipoprotein L-III2 3     apoL-III2
CG12_12 3     Apolipoprotein L32
TNF-Inducible Protein CG12-12 3     ApoL-III3
APOLIII2     

External Ids:    HGNC: 148681   Entrez Gene: 808332   Ensembl: ENSG000001282847   OMIM: 6072535   UniProtKB: O952363   

Export aliases for APOL3 gene to outside databases

Previous GC identifers: GC22M033179 GC22M034808 GC22M034860 GC22M019504


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for APOL3 Gene:
This gene is a member of the apolipoprotein L gene family, and it is present in a cluster with other family
members on chromosome 6. The encoded protein is found in the cytoplasm, where it may affect the movement of
lipids, including cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this
gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic
iliac artery and aorta. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jun
2009)

GeneCards Summary for APOL3 Gene:
APOL3 (apolipoprotein L, 3) is a protein-coding gene. Diseases associated with APOL3 include endotheliitis, and schizophrenia. GO annotations related to this gene include lipid transporter activity and signal transducer activity. An important paralog of this gene is APOL4.

UniProtKB/Swiss-Prot: APOL3_HUMAN, O95236
Function: May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles

Gene Wiki entry for APOL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the APOL3 gene promoter:
         FOXO4   Msx-1   En-1   C/EBPalpha   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): APOL3 promoter sequence
   Search Chromatin IP Primers for APOL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat APOL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q13.1

APOL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOL3 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M036536:  view genomic region     (about GC identifiers)

Start:
36,536,371 bp from pter      End:
36,562,225 bp from pter
Size:
25,855 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: APOL3_HUMAN, O95236 (See protein sequence)
Recommended Name: Apolipoprotein L3  
Size: 402 amino acids; 44278 Da
Secondary accessions: B1AHI4 B1AHI5 Q5U5N4 Q9BQ82 Q9BQA3
Alternative splicing: 3 isoforms:  O95236-1   O95236-2   O95236-3   

Explore the universe of human proteins at neXtProt for APOL3: NX_O95236

Explore proteomics data for APOL3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See APOL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_663615.1  NP_663616.1  NP_663617.1  

    ENSEMBL proteins: 
     ENSP00000344577   ENSP00000416732   ENSP00000409345   ENSP00000380457   ENSP00000355164  
     ENSP00000380456   ENSP00000433618   ENSP00000391174   ENSP00000434449   ENSP00000436331  
     ENSP00000435958   ENSP00000432868   ENSP00000432271   ENSP00000380461   ENSP00000415779  

    APOL3 Human Recombinant Protein Products:

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    Novus Biologicals APOL3 Proteins
    Novus Biologicals APOL3 Lysates
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    Cloud-Clone Corp. Proteins for APOL3

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    APOL3 Assay Products:

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    Cloud-Clone Corp. CLIAs for APOL3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    APOLIPO: Apolipoproteins

    1 InterPro protein domain:
     IPR008405 ApoL

    Graphical View of Domain Structure for InterPro Entry O95236

    ProtoNet protein and cluster: O95236

    1 Blocks protein domain: IPB008405 Apolipoprotein L

    UniProtKB/Swiss-Prot: APOL3_HUMAN, O95236
    Similarity: Belongs to the apolipoprotein L family


    APOL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APOL3_HUMAN, O95236
    Function: May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles
    Induction: In vitro, is responsive to TNF

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IMP12761501
    GO:0005319lipid transporter activity TAS10233894
    GO:0008289lipid binding IEA--
         
    APOL3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for APOL3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for APOL3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for APOL3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for APOL3

    miRNA
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    Block miRNA regulation of human, mouse, rat APOL3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate APOL3
    SwitchGear 3'UTR luciferase reporter plasmidAPOL3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for APOL3
    Predesigned siRNA for gene silencing in human, mouse, rat APOL3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for APOL3

    Clone
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    OriGene clones in human, mouse for APOL3 (see all 32)
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    GenScript: all cDNA clones in your preferred vector (see all 3): APOL3 (NM_145641)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for APOL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOL3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for APOL3
    Browse ESI BIO Cell Lines and PureStem Progenitors for APOL3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOL3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    APOL3_HUMAN, O95236: Cytoplasm (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    extracellular2
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005576extracellular region IEA--
    GO:0005737cytoplasm IEA--

    APOL3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for APOL3 About    
    See pathways by source

    SuperPathContained pathways About
    1Cholesterol and Sphingolipids transport Recycling to plasma membrane in lung normal and CF
    Cholesterol and Sphingolipids transport Recycling to plasma membrane in lung normal and CF

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for APOL3
        Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF)


        Pathway & Disease-focused RT2 Profiler PCR Array including APOL3: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for APOL3

    1 Interacting protein for APOL3 (O952362) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    --Q777C42MINT-6770331
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006869lipid transport ----
    GO:0006954inflammatory response TAS10233894
    GO:0007165signal transduction IMP12761501
    GO:0042157lipoprotein metabolic process IEA--
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling IMP12761501

    APOL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for APOL3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for APOL3 gene (6 alternative transcripts): 
    NM_145640.2  NM_145641.2  NM_145642.2  NM_014349.2  NM_030644.1  NM_145639.1  

    Unigene Cluster for APOL3:

    Apolipoprotein L, 3
    Hs.474737  [show with all ESTs]
    Unigene Representative Sequence: NM_145641
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000349314 ENST00000432700(uc003aor.3) ENST00000422426(uc003aoq.3)
    ENST00000397289 ENST00000361710(uc003aov.3) ENST00000397287(uc003aou.3)
    ENST00000487355 ENST00000487423 ENST00000426939 ENST00000534251 ENST00000531195
    ENST00000487783 ENST00000525184 ENST00000485453 ENST00000530895 ENST00000472303
    ENST00000531095 ENST00000528740
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat APOL3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate APOL3
    SwitchGear 3'UTR luciferase reporter plasmidAPOL3 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat APOL3
    Clone
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    OriGene clones in human, mouse for APOL3 (see all 32)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): APOL3 (NM_145641)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for APOL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOL3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for APOL3
    OriGene qSTAR qPCR primer pairs in human, mouse for APOL3
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat APOL3
      QuantiTect SYBR Green Assays in human, mouse, rat APOL3
      QuantiFast Probe-based Assays in human, mouse, rat APOL3

    Additional mRNA sequence: 

    AF070675.1 AF305227.1 AK025349.1 AK297892.1 AY014902.1 AY014903.1 AY014904.1 AY014905.1 
    AY014906.1 AY014907.1 BC038352.1 BC042918.1 BC050596.1 BC070144.1 CR456379.1 NR_027833.1 
    NR_027834.1 NR_027835.1 

    19 DOTS entries:

    DT.100777098  DT.95169380  DT.87016898  DT.100777094  DT.95169379  DT.100709432  DT.100777099  DT.95169376 
    DT.120660137  DT.95169384  DT.120660102  DT.95361989  DT.99950911  DT.120660114  DT.120660116  DT.120660127 
    DT.120660179  DT.91956193  DT.95318086 

    Selected AceView cDNA sequences (see all 158):

    BC050596 BQ706821 NM_014349 BX105573 BI062360 AA025905 NM_145639 NM_145640 
    AI870966 BF939965 CB529132 AY014904 AA370489 BC038352 AW002766 BU730739 
    BI062001 D79790 BU726522 AY014906 AA345245 AW609829 AY014907 NM_145642 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for APOL3 (see all 15)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g
    SP1:              -     -                       -     -     -     -     -     -     -     -     -     -                                                   
    SP2:                                            -     -     -     -     -     -           -           -                                                   
    SP3:        -     -     -                       -     -     -     -     -     -     -     -     -     -                                                   
    SP4:                                                              -     -     -     -     -     -     -                                                   
    SP5:                                                                                                  -                                                   


    ECgene alternative splicing isoforms for APOL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    APOL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCATTGTCC
    APOL3 Expression
    About this image


    APOL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Endothelium (Cardiovascular System)
             Human umbilical vein endothelial cells (HUVEC)
    APOL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    APOL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.474737

    UniProtKB/Swiss-Prot: APOL3_HUMAN, O95236
    Tissue specificity: Widely expressed; the highest levels are in prostate, lung and placenta; also detected in
    kidney, bone marrow, spleen, thymus, spinal cord, adrenal gland, salivary gland, trachea and mammary gland;
    levels are low in brain, heart, fetal liver, pancreas and testis

        Pathway & Disease-focused RT2 Profiler PCR Array including APOL3: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for APOL3
    OriGene qSTAR qPCR primer pairs in human, mouse for APOL3
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat APOL3
    QuantiTect SYBR Green Assays in human, mouse, rat APOL3
    QuantiFast Probe-based Assays in human, mouse, rat APOL3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for APOL3 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    48(a)
    31(a)
    many ↔ many
    many ↔ many
    5(21779188-21779424)
    5(21745647-21750643)
    zebrafish
    (Danio rerio)
    Actinopterygii APOL46
    apolipoprotein L, 4
    14(a)
    1 → many
    3(29825427-29839518) ENSDARG00000073718
            Species with no ortholog for APOL3

    ENSEMBL Gene Tree for APOL3 (if available)
    TreeFam Gene Tree for APOL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for APOL3 gene
    APOL42  APOL62  APOL22  APOL52  APOL12  
    5 SIMAP similar genes for APOL3 using alignment to 9 protein entries:     APOL3_HUMAN (see all proteins):
    APOL4    APOL2    APOL1    APOL6    ApoL6

    APOL3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for APOL3 (see all 728)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1475640891,2
    C--36535891(+) ATTGGC/TGCCAT 6 -- ds50010--------
    rs1827227541,2
    --36536111(+) CAGGCC/GTGAGC 6 -- ds50010--------
    rs774764921,2
    C,F--36536144(+) TTTTTC/TTTCAC 6 -- ds50011Minor allele frequency- T:0.12WA 118
    rs1176848541,2
    C,F--36536305(+) AAAAAC/TTTCAG 6 -- ds50011Minor allele frequency- T:0.07EA 120
    rs1885903881,2
    --36536314(+) AGACAA/GGAACT 6 -- ds50010--------
    rs1929531361,2
    --36536315(+) GACAGA/GAACTT 6 -- ds50010--------
    rs1840275951,2
    --36536366(+) CTCGAA/GTAAGT 6 -- ds50010--------
    rs1886245321,2
    --36536372(+) TAAGTC/GCAGCT 6 -- ut31 nc-transcript-variant0--------
    rs734196841,2
    C,F--36536442(+) AGATCC/TGGCCT 6 -- ut31 nc-transcript-variant2Minor allele frequency- T:0.06WA 120
    rs96223321,2
    H--36536454(+) ccccaG/Atctct 6 -- ut31 nc-transcript-variantese34Minor allele frequency- A:0.00NS EA 420

    HapMap Linkage Disequilibrium report for APOL3 (36536371 - 36562225 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for APOL3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv271983CNV Insertion20981092
    esv272176CNV Insertion20981092
    nsv521866CNV Loss19592680
    dgv4959n71CNV Loss21882294
    nsv526454CNV Loss19592680
    esv2751964CNV Loss17911159

    Human Gene Mutation Database (HGMD): APOL3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing APOL3
    DNA2.0 Custom Variant and Variant Library Synthesis for APOL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607253    OMIM disorders: --

    6 diseases for APOL3:    
    About MalaCards
    endotheliitis    schizophrenia    hepatitis b    hepatitis
    prostate cancer    prostatitis


    APOL3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): APOL3
    Human Genome Epidemiology (HuGE) Navigator: APOL3 (5 documents)

    Export disorders for APOL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for APOL3 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with APOL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human apolipoprotein L gene cluster: identification, classification, and sites of distribution. (PubMed id 11374903)1, 2, 3 Page N.M.... Lowry P.J. (Genomics 2001)
    2. Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene. (PubMed id 11290834)1, 2, 9 Duchateau P.N.... Kane J.P. (J. Lipid Res. 2001)
    3. Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. (PubMed id 10233894)1, 2, 9 Horrevoets A.J.G.... Pannekoek H. (Blood 1999)
    4. Family-based association analysis of 42 hereditary prostate cancer families identifies the Apolipoprotein L3 region on chromosome 22q12 as a risk locus. (PubMed id 20631155)1, 4 Johanneson B....Ostrander E.A. (Hum. Mol. Genet. 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    7. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    8. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    9. The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue. (PubMed id 11944986)1, 9 Monajemi H.... Horrevoets A.J.G. (Genomics 2002)
    10. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PubMed id 23648065)1 Low S.K....Nakamura Y. (Cancer Sci. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80833 HGNC: 14868 AceView: APOL3 Ensembl:ENSG00000128284 euGenes: HUgn80833
    ECgene: APOL3 H-InvDB: APOL3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for APOL3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for APOL3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for APOL3 gene:
    Search GeneIP for patents involving APOL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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