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Aliases for APOL2 Gene

Aliases for APOL2 Gene

  • Apolipoprotein L2 2 3 5
  • Apolipoprotein L-II 2 3 4
  • APOL-II 3 4
  • Apolipoprotein L, 2 3
  • APOL3 3

External Ids for APOL2 Gene

Previous GeneCards Identifiers for APOL2 Gene

  • GC22M033265
  • GC22M034894
  • GC22M034946
  • GC22M036622
  • GC22M019590

Summaries for APOL2 Gene

Entrez Gene Summary for APOL2 Gene

  • This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOL2 Gene

APOL2 (Apolipoprotein L2) is a Protein Coding gene. Diseases associated with APOL2 include schizophrenia and phencyclidine abuse. Among its related pathways are Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF). GO annotations related to this gene include receptor binding and high-density lipoprotein particle binding. An important paralog of this gene is APOL5.

UniProtKB/Swiss-Prot for APOL2 Gene

  • May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.

Gene Wiki entry for APOL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOL2 Gene

Genomics for APOL2 Gene

Regulatory Elements for APOL2 Gene

Promoters for APOL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around APOL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for APOL2 Gene

Chromosome:
22
Start:
36,226,203 bp from pter
End:
36,239,954 bp from pter
Size:
13,752 bases
Orientation:
Minus strand

Genomic View for APOL2 Gene

Genes around APOL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOL2 Gene

Proteins for APOL2 Gene

  • Protein details for APOL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQE5-APOL2_HUMAN
    Recommended name:
    Apolipoprotein L2
    Protein Accession:
    Q9BQE5
    Secondary Accessions:
    • B0QYK7
    • O95915
    • Q59GW9
    • Q5TH96
    • Q969T6
    • Q9BT28
    • Q9UGT1
    • Q9UH10

    Protein attributes for APOL2 Gene

    Size:
    337 amino acids
    Molecular mass:
    37092 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD92227.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for APOL2 Gene

Proteomics data for APOL2 Gene at MOPED

Post-translational modifications for APOL2 Gene

  • Ubiquitination at Lys 83, Lys 193, Lys 196, Lys 320, and Lys 326
  • Modification sites at PhosphoSitePlus

Other Protein References for APOL2 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for APOL2

No data available for DME Specific Peptides for APOL2 Gene

Domains & Families for APOL2 Gene

Gene Families for APOL2 Gene

Protein Domains for APOL2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for APOL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BQE5

UniProtKB/Swiss-Prot:

APOL2_HUMAN :
  • Belongs to the apolipoprotein L family.
Family:
  • Belongs to the apolipoprotein L family.
genes like me logo Genes that share domains with APOL2: view

Function for APOL2 Gene

Molecular function for APOL2 Gene

GENATLAS Biochemistry:
apolipoprotein L,2
UniProtKB/Swiss-Prot Function:
May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.

Gene Ontology (GO) - Molecular Function for APOL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008035 high-density lipoprotein particle binding NAS 11374903
genes like me logo Genes that share ontologies with APOL2: view
genes like me logo Genes that share phenotypes with APOL2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for APOL2 Gene

Localization for APOL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOL2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOL2 Gene COMPARTMENTS Subcellular localization image for APOL2 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 3
plasma membrane 3
extracellular 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for APOL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with APOL2: view

Pathways & Interactions for APOL2 Gene

genes like me logo Genes that share pathways with APOL2: view

Pathways by source for APOL2 Gene

Interacting Proteins for APOL2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000249066%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000363822%0d%0a
Selected Interacting proteins: Q9BQE5-APOL2_HUMAN ENSP00000249066 for APOL2 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for APOL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport IEA,NAS 11374903
GO:0006953 acute-phase response NAS 11374903
GO:0007275 multicellular organism development NAS 11374903
GO:0042157 lipoprotein metabolic process IEA --
genes like me logo Genes that share ontologies with APOL2: view

No data available for SIGNOR curated interactions for APOL2 Gene

Drugs & Compounds for APOL2 Gene

No Compound Related Data Available

Transcripts for APOL2 Gene

Unigene Clusters for APOL2 Gene

Apolipoprotein L, 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APOL2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f · 4g ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: -
SP7: - - -
SP8: - - -
SP9: - -
SP10: -

Relevant External Links for APOL2 Gene

GeneLoc Exon Structure for
APOL2
ECgene alternative splicing isoforms for
APOL2

Expression for APOL2 Gene

mRNA expression in normal human tissues for APOL2 Gene

Protein differential expression in normal tissues from HIPED for APOL2 Gene

This gene is overexpressed in Nasal epithelium (26.1) and Bone (19.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for APOL2 Gene



SOURCE GeneReport for Unigene cluster for APOL2 Gene Hs.474740

mRNA Expression by UniProt/SwissProt for APOL2 Gene

Q9BQE5-APOL2_HUMAN
Tissue specificity: Widely expressed; the highest levels are found in lung, thymus, pancreas, placenta, adult brain and prostate; also detected in spleen, liver, kidney, colon, small intestine, uterus, spinal cord, adrenal gland, salivary gland, trachea, mammary gland, skeletal muscle, testis and fetal brain and liver.
genes like me logo Genes that share expression patterns with APOL2: view

Protein tissue co-expression partners for APOL2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for APOL2 Gene

Orthologs for APOL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia APOL3 35
  • 66.56 (n)
  • 46.96 (a)
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
APOL3 36
  • 42 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Apol8 35
  • 64.73 (n)
  • 45.57 (a)
Apol8 16
Apol10a 36
  • 30 (a)
ManyToMany
Apol10b 36
  • 34 (a)
ManyToMany
Apol11a 36
  • 34 (a)
ManyToMany
Apol11b 36
  • 30 (a)
ManyToMany
Apol9a 36
  • 38 (a)
ManyToMany
Apol9b 36
  • 41 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia APOL2 35
  • 98.62 (n)
  • 97.33 (a)
APOL2 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911804 35
  • 64.09 (n)
  • 45.54 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 38 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 22 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 28 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii APOL4 36
  • 13 (a)
OneToMany
Species with no ortholog for APOL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APOL2 Gene

ENSEMBL:
Gene Tree for APOL2 (if available)
TreeFam:
Gene Tree for APOL2 (if available)

Paralogs for APOL2 Gene

Paralogs for APOL2 Gene

(5) SIMAP similar genes for APOL2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for APOL2 Gene

genes like me logo Genes that share paralogs with APOL2: view

Variants for APOL2 Gene

Sequence variations from dbSNP and Humsavar for APOL2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs132760 - 36,227,685(+) AATGA(C/T)ATGCG reference, missense
rs7285167 - 36,227,874(+) GTTGC(A/C/G/T)GGCTT reference, missense
rs132758 -- 36,226,671(+) GGGGG(-/G/GG/GGG)TCGGT utr-variant-3-prime
rs132759 -- 36,227,102(+) CGAGG(C/T)CAGGA utr-variant-3-prime
rs129607 -- 36,226,860(+) AGTCC(C/T)CTCTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for APOL2 Gene

Variant ID Type Subtype PubMed ID
nsv915006 CNV Loss 21882294
esv7844 OTHER Inversion 19470904
nsv522931 CNV Gain 19592680
esv1003985 CNV Deletion 20482838
nsv834185 CNV Loss 17160897

Variation tolerance for APOL2 Gene

Residual Variation Intolerance Score: 80% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.42; 88.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for APOL2 Gene

HapMap Linkage Disequilibrium report
APOL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOL2 Gene

Disorders for APOL2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for APOL2 Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
phencyclidine abuse
  • pcp abuse
- elite association - COSMIC cancer census association via MalaCards
Search APOL2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for APOL2

Genetic Association Database (GAD)
APOL2
Human Genome Epidemiology (HuGE) Navigator
APOL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APOL2
genes like me logo Genes that share disorders with APOL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for APOL2 Gene

Publications for APOL2 Gene

  1. The human apolipoprotein L gene cluster: identification, classification, and sites of distribution. (PMID: 11374903) Page N.M. … Lowry P.J. (Genomics 2001) 2 3 4 67
  2. Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene. (PMID: 11290834) Duchateau P.N. … Kane J.P. (J. Lipid Res. 2001) 3 23
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Apolipoprotein L2 contains a BH3-like domain but it does not behave as a BH3-only protein. (PMID: 24901046) Galindo-Moreno J. … MuA+oz-Pinedo C. (Cell Death Dis 2014) 3

Products for APOL2 Gene

Sources for APOL2 Gene

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