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Aliases for APOL2 Gene

Aliases for APOL2 Gene

  • Apolipoprotein L, 2 2 3
  • Apolipoprotein L-II 2 3 4
  • APOL-II 3 4
  • Apolipoprotein L2 3
  • APOL3 3

External Ids for APOL2 Gene

Previous GeneCards Identifiers for APOL2 Gene

  • GC22M033265
  • GC22M034894
  • GC22M034946
  • GC22M036622
  • GC22M019590

Summaries for APOL2 Gene

Entrez Gene Summary for APOL2 Gene

  • This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOL2 Gene

APOL2 (Apolipoprotein L, 2) is a Protein Coding gene. Diseases associated with APOL2 include schizophrenia. Among its related pathways are Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF). GO annotations related to this gene include receptor binding and high-density lipoprotein particle binding. An important paralog of this gene is APOL5.

UniProtKB/Swiss-Prot for APOL2 Gene

  • May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles

Gene Wiki entry for APOL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOL2 Gene

Genomics for APOL2 Gene

Regulatory Elements for APOL2 Gene

Genomic Location for APOL2 Gene

36,226,203 bp from pter
36,239,954 bp from pter
13,752 bases
Minus strand

Genomic View for APOL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APOL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOL2 Gene

Proteins for APOL2 Gene

  • Protein details for APOL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Apolipoprotein L2
    Protein Accession:
    Secondary Accessions:
    • B0QYK7
    • O95915
    • Q59GW9
    • Q5TH96
    • Q969T6
    • Q9BT28
    • Q9UGT1
    • Q9UH10

    Protein attributes for APOL2 Gene

    337 amino acids
    Molecular mass:
    37092 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAD92227.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for APOL2 Gene

Proteomics data for APOL2 Gene at MOPED

Post-translational modifications for APOL2 Gene

  • Ubiquitination at Lys83, Lys193, Lys196, Lys320, and Lys326
  • Modification sites at PhosphoSitePlus

Other Protein References for APOL2 Gene

No data available for DME Specific Peptides for APOL2 Gene

Domains for APOL2 Gene

Gene Families for APOL2 Gene


Protein Domains for APOL2 Gene


Suggested Antigen Peptide Sequences for APOL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BQE5
  • Belongs to the apolipoprotein L family.
genes like me logo Genes that share domains with APOL2: view

Function for APOL2 Gene

Molecular function for APOL2 Gene

GENATLAS Biochemistry: apolipoprotein L,2
UniProtKB/Swiss-Prot Function: May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles

Gene Ontology (GO) - Molecular Function for APOL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding NAS 11374903
GO:0008035 high-density lipoprotein particle binding NAS 11374903
GO:0008289 lipid binding NAS 11374903
genes like me logo Genes that share ontologies with APOL2: view

Phenotypes for APOL2 Gene

GenomeRNAi human phenotypes for APOL2:
genes like me logo Genes that share phenotypes with APOL2: view

Animal Model Products

CRISPR Products

miRNA for APOL2 Gene

miRTarBase miRNAs that target APOL2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APOL2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for APOL2 Gene

Localization for APOL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOL2 Gene


Subcellular locations from

Jensen Localization Image for APOL2 Gene COMPARTMENTS Subcellular localization image for APOL2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
extracellular 2
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for APOL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005789 endoplasmic reticulum membrane NAS 11374903
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with APOL2: view

Pathways for APOL2 Gene

genes like me logo Genes that share pathways with APOL2: view

Pathways by source for APOL2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for APOL2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000249066 Q9BQE5-APOL2_HUMAN for APOL2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for APOL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process NAS 11374903
GO:0006869 lipid transport NAS 11374903
GO:0006953 acute-phase response NAS 11374903
GO:0007275 multicellular organismal development NAS 11374903
GO:0008203 cholesterol metabolic process NAS 11374903
genes like me logo Genes that share ontologies with APOL2: view

Transcripts for APOL2 Gene

Unigene Clusters for APOL2 Gene

Apolipoprotein L, 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APOL2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for APOL2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f · 4g ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: -
SP7: - - -
SP8: - - -
SP9: - -
SP10: -

Relevant External Links for APOL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for APOL2 Gene

mRNA expression in normal human tissues for APOL2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for APOL2 Gene

SOURCE GeneReport for Unigene cluster for APOL2 Gene Hs.474740

mRNA Expression by UniProt/SwissProt for APOL2 Gene

Tissue specificity: Widely expressed; the highest levels are found in lung, thymus, pancreas, placenta, adult brain and prostate; also detected in spleen, liver, kidney, colon, small intestine, uterus, spinal cord, adrenal gland, salivary gland, trachea, mammary gland, skeletal muscle, testis and fetal brain and liver
genes like me logo Genes that share expressions with APOL2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for APOL2 Gene

Orthologs for APOL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia APOL2 35
  • 98.62 (n)
  • 97.33 (a)
APOL2 36
  • 97 (a)
(Bos Taurus)
Mammalia -- 36
  • 43 (a)
-- 36
  • 35 (a)
APOL3 35
  • 66.56 (n)
  • 46.96 (a)
APOL3 36
  • 42 (a)
(Canis familiaris)
Mammalia -- 36
  • 38 (a)
(Mus musculus)
Mammalia Apol10a 36
  • 30 (a)
Apol10b 36
  • 34 (a)
Apol11a 36
  • 34 (a)
Apol11b 36
  • 30 (a)
Apol8 35
  • 64.73 (n)
  • 45.57 (a)
Apol8 16
Apol9a 36
  • 38 (a)
Apol9b 36
  • 41 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 22 (a)
-- 36
  • 25 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 28 (a)
(Rattus norvegicus)
Mammalia LOC100911804 35
  • 64.09 (n)
  • 45.54 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
-- 36
  • 44 (a)
(Danio rerio)
Actinopterygii APOL4 36
  • 13 (a)
Species with no ortholog for APOL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APOL2 Gene

Gene Tree for APOL2 (if available)
Gene Tree for APOL2 (if available)

Paralogs for APOL2 Gene

Paralogs for APOL2 Gene

Selected SIMAP similar genes for APOL2 Gene using alignment to 4 proteins: Pseudogenes for APOL2 Gene

genes like me logo Genes that share paralogs with APOL2: view

Variants for APOL2 Gene

Sequence variations from dbSNP and Humsavar for APOL2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs129607 -- 36,226,860(+) AGTCC(C/T)CTCTC utr-variant-3-prime
rs132758 -- 36,226,671(+) GGGGG(-/G/GG/GGG)TCGGT utr-variant-3-prime
rs132759 -- 36,227,102(+) CGAGG(C/T)CAGGA utr-variant-3-prime
rs132760 - 36,227,685(+) AATGA(C/T)ATGCG missense, reference
rs136142 -- 36,236,979(+) CTCAA(C/T)GCCAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for APOL2 Gene

Variant ID Type Subtype PubMed ID
nsv915006 CNV Loss 21882294
esv7844 OTHER Inversion 19470904
nsv522931 CNV Gain 19592680
esv1003985 CNV Deletion 20482838
nsv834185 CNV Loss 17160897

Relevant External Links for APOL2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOL2 Gene

Disorders for APOL2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for APOL2 Gene including...

Search for APOL2 Gene in MalaCards »

(1) OMIM Diseases for APOL2 Gene (607252)

(1) University of Copenhagen DISEASES for APOL2 Gene

Relevant External Links for APOL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with APOL2: view

No data available for UniProtKB/Swiss-Prot for APOL2 Gene

Publications for APOL2 Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 4
  2. The human apolipoprotein L gene cluster: identification, classification, and sites of distribution. (PMID: 11374903) Page N.M. … Lowry P.J. (Genomics 2001) 2 3 4
  3. Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene. (PMID: 11290834) Duchateau P.N. … Kane J.P. (J. Lipid Res. 2001) 3 4 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue. (PMID: 11944986) Monajemi H. … Horrevoets A.J.G. (Genomics 2002) 3 4

Products for APOL2 Gene

Sources for APOL2 Gene

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