Aliases for APOL1 Gene
Aliases for APOL1 Gene
External Ids for APOL1 Gene
- HGNC: 618
- Entrez Gene: 8542
- Ensembl: ENSG00000100342
- OMIM: 603743
- UniProtKB: O14791
Previous HGNC Symbols for APOL1 Gene
- APOL
Previous GeneCards Identifiers for APOL1 Gene
- GC22P033292
- GC22P034920
- GC22P034973
- GC22P036649
- GC22P019617
Summaries for APOL1 Gene
-
This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
GeneCards Summary for APOL1 Gene
APOL1 (Apolipoprotein L1) is a Protein Coding gene. Diseases associated with APOL1 include Glomerulosclerosis, Focal Segmental, 4 and Sleeping Sickness. Among its related pathways are Vesicle-mediated transport and Binding and Uptake of Ligands by Scavenger Receptors. GO annotations related to this gene include lipid binding and chloride channel activity. An important paralog of this gene is APOL2.
UniProtKB/Swiss-Prot for APOL1 Gene
-
May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOL1 Gene
Genomics for APOL1 Gene
Regulatory Elements for APOL1 Gene
Enhancers for APOL1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH22G037165 | 1.6 | Ensembl ENCODE dbSUPER | 5.5 | +914.6 | 914585 | 3.5 | HDGF FOXA2 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 | ENSG00000235237 APOL1 IL2RB |
| GH22G036257 | 1.3 | Ensembl ENCODE dbSUPER | 5.6 | +6.3 | 6251 | 3.0 | HDGF PKNOX1 ZSCAN4 BMI1 ZBTB40 ZNF366 SCRT2 RELB IKZF2 ELF4 | EIF3D APOL1 APOL4 MIR6819 |
| GH22G036351 | 0.6 | dbSUPER | 6.1 | +94.5 | 94521 | 1.1 | ZMYM3 MAX MIER2 REST ZNF623 RAD21 NR2F2 ZBTB48 POLR2A HNF4A | ENSG00000252225 APOL1 GC22M036355 GC22M036334 |
| GH22G036353 | 0.6 | dbSUPER | 6.1 | +94.6 | 94606 | 0.9 | ZMYM3 MAX MIER2 REST ZNF623 RAD21 NR2F2 ZBTB48 POLR2A HNF4A | ENSG00000252225 APOL1 GC22M036355 GC22M036334 |
| GH22G036449 | 1.7 | FANTOM5 ENCODE dbSUPER | 1.6 | +199.8 | 199842 | 7.4 | HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 | CSF2RB APOL3 APOL2 NCF4 FOXRED2 ENSG00000228719 TXN2 APOL1 ENSG00000252225 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around APOL1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the APOL1 gene promoter:
Regulatory Element Products
Genomic Location for APOL1 Gene
- Chromosome:
- 22
- Start:
- 36,253,010 bp from pter
- End:
- 36,267,531 bp from pter
- Size:
- 14,522 bases
- Orientation:
- Plus strand
Genomic View for APOL1 Gene
Genes around APOL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q12.3 by Ensembl
- 22q12.3 by Entrez Gene
- 22q12.3 by HGNC
APOL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for APOL1 Gene
Proteins for APOL1 Gene
-
Protein details for APOL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O14791-APOL1_HUMAN
- Recommended name:
- Apolipoprotein L1
- Protein Accession:
- O14791
- A5PLQ4
- B4DU12
- E9PF24
- O60804
- Q5R3P7
- Q5R3P8
- Q96AB8
- Q96PM4
- Q9BQ03
Protein attributes for APOL1 Gene
- Size:
- 398 amino acids
- Molecular mass:
- 43974 Da
- Quaternary structure:
-
- In plasma, interacts with APOA1 and mainly associated with large high density lipoprotein particles.
- SequenceCaution:
-
- Sequence=AAB81218.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for APOL1 Gene
Post-translational modifications for APOL1 Gene
- Phosphorylated by FAM20C in the extracellular medium.
- Glycosylation at posLast=236236 and posLast=261261
- Modification sites at PhosphoSitePlus
Other Protein References for APOL1 Gene
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for APOL1
-
Custom Antibody ServicesOriGene Antibodies for APOL1
- Novus Biologicals Antibodies for APOL1
-
Cloud-Clone Corp. Antibodies for APOL1
- Invitrogen Antibodies for APOL1
- antibodies-online Antibodies for APOL1: See all 108
- GeneTex APOL1 antibody for APOL1
-
Santa Cruz Biotechnology (SCBT) Antibodies for APOL1
Protein Products
-
OriGene Purified Proteins for APOL1
- Search Origene for MassSpec and Protein Over-expression Lysates for APOL1
- Origene Custom Protein Services for APOL1
- Sino Biological Recombinant Proteins for APOL1
- Sino Biological Cell Lysates for APOL1
-
Cloud-Clone Corp. Proteins for APOL1
- antibodies-online Proteins for APOL1: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for APOL1
Assay Products
- antibodies-online Kits for APOL1: See all 26
No data available for DME Specific Peptides for APOL1 Gene
Domains & Families for APOL1 Gene
Gene Families for APOL1 Gene
- HGNC:
Protein Domains for APOL1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for APOL1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O14791- Family:
-
- Belongs to the apolipoprotein L family.
Function for APOL1 Gene
Molecular function for APOL1 Gene
- UniProtKB/Swiss-Prot Function:
- May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005254 | chloride channel activity | IDA | 16020735 |
| GO:0005515 | protein binding | IPI | 12621437 |
| GO:0008289 | lipid binding | IDA | 16020735 |
Phenotypes for APOL1 Gene
- GenomeRNAi human phenotypes for APOL1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for APOL1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for APOL1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for APOL1 gene
- Search ViGene Biosciences for APOL1
CRISPR Products
-
OriGene CRISPR knockouts for APOL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for APOL1
- GenScript: Design CRISPR guide RNA sequences for APOL1
miRNA for APOL1 Gene
- miRTarBase miRNAs that target APOL1
-
- hsa-mir-4279 (MIRT690952)
- hsa-mir-4284 (MIRT690953)
- hsa-mir-2276-3p (MIRT690954)
- hsa-mir-1976 (MIRT690955)
- hsa-mir-3653-5p (MIRT690956)
- hsa-mir-1304-3p (MIRT690957)
- hsa-mir-6741-3p (MIRT690958)
- hsa-mir-6747-3p (MIRT690959)
- hsa-mir-6727-3p (MIRT690960)
- hsa-mir-4722-3p (MIRT690961)
- hsa-mir-4726-3p (MIRT690962)
- hsa-mir-6764-5p (MIRT690963)
- hsa-mir-1915-3p (MIRT690964)
- hsa-mir-6840-3p (MIRT690965)
- hsa-mir-6890-3p (MIRT690966)
- hsa-mir-1306-5p (MIRT690967)
- hsa-mir-122-3p (MIRT690968)
miRNA Products
- Search ViGene Biosciences for APOL1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for APOL1
- Browse OriGene Inhibitory RNA Products For APOL1
-
ViGene Biosciences ready-to-package AAV shRNAs for APOL1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for APOL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APOL1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for APOL1
-
ViGene Biosciences adenoviral particle packaged cDNA for APOL1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for APOL1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for APOL1 gene
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA6-14282) for APOL1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for APOL1 Gene
Localization for APOL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for APOL1 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 3 |
| plasma membrane | 2 |
| lysosome | 2 |
| endosome | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IDA | 17192540 |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
| GO:0031224 | intrinsic component of membrane | IC | 16020735 |
| GO:0034361 | very-low-density lipoprotein particle | IDA | 17154273 |
Pathways & Interactions for APOL1 Gene
Pathways by source for APOL1 Gene
3 Reactome pathways for APOL1 Gene
1 KEGG pathway for APOL1 Gene
1 GeneGo (Thomson Reuters) pathway for APOL1 Gene
Interacting Proteins for APOL1 Gene
Selected Interacting proteins:
ENSP00000317674
O14791-APOL1_HUMAN
for APOL1 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006810 | transport | IEA | -- |
| GO:0006869 | lipid transport | IEA | -- |
| GO:0006898 | receptor-mediated endocytosis | TAS | -- |
| GO:0008202 | steroid metabolic process | IEA | -- |
No data available for SIGNOR curated interactions for APOL1 Gene
Transcripts for APOL1 Gene
mRNA/cDNA for APOL1 Gene
- (7) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (328) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for APOL1
-
Santa Cruz Biotechnology (SCBT) CRISPR for APOL1
- GenScript: Design CRISPR guide RNA sequences for APOL1
miRNA Products
- Search ViGene Biosciences for APOL1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for APOL1
- Browse OriGene Inhibitory RNA Products For APOL1
-
ViGene Biosciences ready-to-package AAV shRNAs for APOL1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for APOL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APOL1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA6-14282) for APOL1
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | · | 7c | · | 7d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - |
Expression for APOL1 Gene
mRNA differential expression in normal tissues according to GTEx for APOL1 Gene
This gene is overexpressed in Liver (x5.7).
This gene is overexpressed in Serum (30.7), Synovial fluid (13.8), and Plasma (12.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for APOL1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of APOL1 Gene:
APOL1SOURCE GeneReport for Unigene cluster for APOL1 Gene:
Hs.114309mRNA Expression by UniProt/SwissProt for APOL1 Gene:
O14791-APOL1_HUMAN
Tissue specificity:
Plasma. Found on APOA-I-containing high density lipoprotein (HDL3). Expressed in pancreas, lung, prostate, liver, placenta and spleen.
Evidence on tissue expression from TISSUES for APOL1 Gene
- Liver(4.5)
- Pancreas(4.3)
- Bone marrow(4.1)
- Nervous system(3.8)
- Kidney(3.7)
- Stomach(3.7)
- Spleen(3.4)
- Lung(3.3)
- Blood(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for APOL1 Gene
Germ Layers:
- mesoderm
Systems:
- urinary
Organs:
Abdomen:
- kidney
Primer Products
-
OriGene qPCR primer pairs for APOL1
-
OriGene qPCR primer pairs and template standards for APOL1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for APOL1 Gene
Orthologs for APOL1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
ManyToMany | |
| cow (Bos Taurus) |
Mammalia | APOL3 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| mouse (Mus musculus) |
Mammalia | Apol9b 35 |
|
ManyToMany | |
| Apol10b 35 |
|
ManyToMany | |||
| Apol9a 35 |
|
ManyToMany | |||
| Apol11a 35 |
|
ManyToMany | |||
| Apol10a 35 |
|
ManyToMany | |||
| Apol11b 35 |
|
ManyToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| zebrafish (Danio rerio) |
Actinopterygii | APOL4 35 |
|
OneToMany |
- Species where no ortholog for APOL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for APOL1 Gene
(5) SIMAP similar genes for APOL1 Gene using alignment to 36 proteins:
- APOL1_HUMAN
- A5PL32_HUMAN
- B1AH94_HUMAN
- B1AH95_HUMAN
- B1AH96_HUMAN
- F8WB77_HUMAN
- F8WCH3_HUMAN
- G8JL88_HUMAN
- L8ECA5_HUMAN
- Q1WWL5_HUMAN
- Q29RW7_HUMAN
- Q2KHQ6_HUMAN
- U5LGU2_HUMAN
- U5LGW0_HUMAN
- U5LGY0_HUMAN
- U5LH46_HUMAN
- U5LH96_HUMAN
- U5LHF6_HUMAN
- U5LI90_HUMAN
- U5LIA9_HUMAN
- U5LIC5_HUMAN
- U5LIG7_HUMAN
- U5LIH6_HUMAN
- U5LII8_HUMAN
- U5LIJ1_HUMAN
- U5LKC6_HUMAN
- U5LKG0_HUMAN
- U5LKH9_HUMAN
- U5LKJ0_HUMAN
- U5LKM6_HUMAN
- U5LKN0_HUMAN
- U5LKN4_HUMAN
- U5LKP5_HUMAN
- U5LKQ0_HUMAN
- U5LKR8_HUMAN
- U5LKT7_HUMAN
Pseudogenes.org Pseudogenes for APOL1 Gene
Variants for APOL1 Gene
| SNP ID | Clin | Chr 22 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs60910145 | other, Focal segmental glomerulosclerosis 4 (FSGS4) [MIM:612551] | 36,265,988(+) | AACAT(G/T)CTCAA | reference, missense | |
| rs73885319 | other, Focal segmental glomerulosclerosis 4 (FSGS4) [MIM:612551] | 36,265,860(+) | CTGTA(A/G)GCTTC | reference, missense | |
| VAR_036568 | A breast cancer sample | ||||
| rs71785313 | other | 36,266,000(+) | CAACA(-/TTATAA)ATAAG | cds-indel | |
| rs1000027871 | -- | 36,267,781(+) | CAGGA(A/T)CAGGT | downstream-variant-500B |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4564n100 | CNV | gain | 25217958 |
| esv2760715 | CNV | gain | 21179565 |
| esv3647682 | CNV | gain | 21293372 |
| esv7844 | OTHER | inversion | 19470904 |
| nsv1114320 | CNV | deletion | 24896259 |
| nsv1129335 | OTHER | inversion | 24896259 |
| nsv522931 | CNV | gain | 19592680 |
| nsv834185 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
86.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.95;
68.02% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for APOL1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOL1 Gene
Disorders for APOL1 Gene
(7) MalaCards diseases for APOL1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| glomerulosclerosis, focal segmental, 4 |
|
|
| sleeping sickness |
|
|
| trypanosomiasis |
|
|
| sporadic idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis |
|
|
| phencyclidine abuse |
|
|
Search APOL1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
APOL1_HUMAN- Focal segmental glomerulosclerosis 4 (FSGS4) [MIM:612551]: A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. {ECO:0000269 PubMed:20635188, ECO:0000269 PubMed:20647424}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for APOL1
No data available for Genatlas for APOL1 Gene
Publications for APOL1 Gene
- The human apolipoprotein L gene cluster: identification, classification, and sites of distribution. (PMID: 11374903) Page N.M. … Lowry P.J. (Genomics 2001) 2 3 4 22 64
- Apolipoprotein L, a new human high density lipoprotein apolipoprotein expressed by the pancreas. Identification, cloning, characterization, and plasma distribution of apolipoprotein L. (PMID: 9325276) Duchateau P.N. … Kane J.P. (J. Biol. Chem. 1997) 2 3 4 22 64
- Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene. (PMID: 20635188) Tzur S. … Skorecki K. (Hum. Genet. 2010) 3 4 46 64
- Association of trypanolytic ApoL1 variants with kidney disease in African Americans. (PMID: 20647424) Genovese G. … Pollak M.R. (Science 2010) 3 4 46 64
- Association of SNPs and haplotypes in APOL1, 2 and 4 with schizophrenia. (PMID: 18632255) Takahashi S. … Tsuang M.T. (Schizophr. Res. 2008) 3 22 46 64
Products for APOL1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for APOL1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for APOL1
- Search Origene for MassSpec and Protein Over-expression Lysates for APOL1
- Origene Custom Protein Services for APOL1
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for APOL1
- Browse OriGene Inhibitory RNA Products For APOL1
- OriGene qPCR primer pairs and template standards for APOL1
- OriGene qPCR primer pairs for APOL1
- OriGene CRISPR knockouts for APOL1
- OriGene ORF clones in human for APOL1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For APOL1
- GenScript: Next-day shipping cDNA ORF clone for APOL1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for APOL1
- GenScript Custom Assay Services for APOL1
- GenScript Custom overexpressing Cell Line Services for APOL1
- GenScript: Design CRISPR guide RNA sequences for APOL1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for APOL1
- Browse Sino Biological cDNA Clones
- Sino Biological Recombinant Proteins for APOL1
- Sino Biological Cell Lysates for APOL1
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for APOL1
- Novus Biologicals proteins and lysates for APOL1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cloud-Clone Corp. Antibodies for APOL1
- Cloud-Clone Corp. Proteins for APOL1
- antibodies-online Antibodies for APOL1: See all 108
- antibodies-online Kits for APOL1: See all 26
- antibodies-online Proteins for APOL1: See all 5
- Search antibodies-online for peptides
- GeneTex APOL1 antibody for APOL1
- Search GeneTex for Proteins for APOL1
- ViGene Biosciences adenoviral particle packaged cDNA for APOL1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for APOL1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for APOL1 gene
- Search ViGene Biosciences for APOL1
- Santa Cruz Biotechnology (SCBT) Antibodies for APOL1
- Search Santa Cruz Biotechnology (SCBT) for APOL1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for APOL1
- Horizon Cell Lines for APOL1
- Cyagen custom Knockout/knockin (KOKI) mouse models for APOL1
- VectorBuilder custom plasmid, inducible vectors for APOL1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APOL1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for APOL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer