Aliases for APOL1 Gene
External Ids for APOL1 Gene
Previous Symbols for APOL1 Gene
This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
GeneCards Summary for APOL1 Gene
APOL1 (Apolipoprotein L, 1) is a Protein Coding gene. Diseases associated with APOL1 include phencyclidine abuse and sleeping sickness. Among its related pathways are Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF) and Binding and Uptake of Ligands by Scavenger Receptors. GO annotations related to this gene include lipid binding and chloride channel activity. An important paralog of this gene is APOL5.
UniProtKB/Swiss-Prot for APOL1 Gene
May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver