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Aliases for APOH Gene

Aliases for APOH Gene

  • Apolipoprotein H (Beta-2-Glycoprotein I) 2 3
  • Activated Protein C-Binding Protein 3 4
  • Anticardiolipin Cofactor 3 4
  • Beta-2-Glycoprotein I 2 4
  • APC Inhibitor 3 4
  • Beta(2)GPI 3 4
  • Apo-H 3 4
  • B2GPI 3 4
  • B2G1 3 4
  • Beta-2-Glycoprotein 1 3
  • Apolipoprotein H 4
  • B2GP1 3
  • BG 3

External Ids for APOH Gene

Previous HGNC Symbols for APOH Gene

  • B2G1

Previous GeneCards Identifiers for APOH Gene

  • GC17P064187
  • GC17P067253
  • GC17M064625
  • GC17M064758
  • GC17M061638
  • GC17M064208
  • GC17M059599

Summaries for APOH Gene

Entrez Gene Summary for APOH Gene

  • Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOH Gene

APOH (Apolipoprotein H (Beta-2-Glycoprotein I)) is a Protein Coding gene. Diseases associated with APOH include connective tissue disease and middle cerebral artery infarction. GO annotations related to this gene include identical protein binding and heparin binding. An important paralog of this gene is CSMD3.

UniProtKB/Swiss-Prot for APOH Gene

  • Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells

Gene Wiki entry for APOH Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOH Gene

Genomics for APOH Gene

Regulatory Elements for APOH Gene

Genomic Location for APOH Gene

Start:
66,212,029 bp from pter
End:
66,256,525 bp from pter
Size:
44,497 bases
Orientation:
Minus strand

Genomic View for APOH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APOH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOH Gene

Proteins for APOH Gene

  • Protein details for APOH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02749-APOH_HUMAN
    Recommended name:
    Beta-2-glycoprotein 1
    Protein Accession:
    P02749
    Secondary Accessions:
    • B2R9M3
    • Q9UCN7

    Protein attributes for APOH Gene

    Size:
    345 amino acids
    Molecular mass:
    38298 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for APOH Gene

neXtProt entry for APOH Gene

Proteomics data for APOH Gene at MOPED

Post-translational modifications for APOH Gene

  • N- and O-glycosylated. PubMed:6587378 also reports glycosylation on Asn-188 for their allele.
  • Glycosylation at Thr149, Asn162, Asn183, Asn193, and Asn253
  • Modification sites at PhosphoSitePlus

Other Protein References for APOH Gene

Antibody Products

  • R&D Systems Antibodies for APOH (Apolipoprotein H/ApoH)

No data available for DME Specific Peptides for APOH Gene

Domains for APOH Gene

Gene Families for APOH Gene

HGNC:

Protein Domains for APOH Gene

Suggested Antigen Peptide Sequences for APOH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P02749

UniProtKB/Swiss-Prot:

APOH_HUMAN :
  • P02749
Domain:
  • Contains 4 Sushi (CCP/SCR) domains.
genes like me logo Genes that share domains with APOH: view

Function for APOH Gene

Molecular function for APOH Gene

GENATLAS Biochemistry:
apolipoprotein H (beta-2-glycoprotein I),precursor activator of lipoprotein lipase,cofactor for the binding of antianionic phospholipid autoantibodies
UniProtKB/Swiss-Prot Function:
Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells

Gene Ontology (GO) - Molecular Function for APOH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IPI 9269765
GO:0005515 protein binding IPI 16480936
GO:0005543 phospholipid binding IDA 15486070
GO:0008201 heparin binding IEA --
GO:0008289 lipid binding IDA 222615
genes like me logo Genes that share ontologies with APOH: view

Phenotypes for APOH Gene

genes like me logo Genes that share phenotypes with APOH: view

Animal Models for APOH Gene

MGI Knock Outs for APOH:

Animal Model Products

miRNA for APOH Gene

miRTarBase miRNAs that target APOH

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APOH

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for APOH Gene

Localization for APOH Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOH Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOH Gene COMPARTMENTS Subcellular localization image for APOH gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for APOH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 15486070
GO:0009986 cell surface IDA 16480936
GO:0031012 colocalizes_with extracellular matrix IDA 20551380
GO:0034361 very-low-density lipoprotein particle IDA 222615
GO:0034364 high-density lipoprotein particle IDA 222615
genes like me logo Genes that share ontologies with APOH: view

Pathways for APOH Gene

SuperPathways for APOH Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for APOH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001937 negative regulation of endothelial cell proliferation IDA 17872974
GO:0006641 triglyceride metabolic process IDA 7417307
GO:0007597 blood coagulation, intrinsic pathway IDA 4052628
GO:0010596 negative regulation of endothelial cell migration IDA 17872974
GO:0016525 negative regulation of angiogenesis IDA 17872974
genes like me logo Genes that share ontologies with APOH: view

No data available for Pathways by source for APOH Gene

Compounds for APOH Gene

(94) HMDB Compounds for APOH Gene

Compound Synonyms Cas Number PubMed IDs
CL(18:1(11Z)/18:1(11Z)/18:1(11Z)/18:1(11Z))
  • Cardiolipins(72:4)
Not Available
CL(18:1(11Z)/18:1(11Z)/18:1(11Z)/18:2(9Z,12Z))
  • Cardiolipins(72:4)
Not Available
CL(18:1(9Z)/18:1(9Z)/18:1(9Z)/18:1(9Z))
  • Cardiolipin(18:1n9/18:1n9/18:1n9/18:1n9)
Not Available
CL(18:1(9Z)/18:1(9Z)/18:1(9Z)/18:2(9Z,12Z))
  • Cardiolipin(18:1n9/18:1n9/18:1n9/18:1n9)
Not Available
CL(18:2(9Z,12Z)/18:1(11Z)/18:1(11Z)/16:0)
  • Cardiolipins(72:5)
Not Available

(1) Drugbank Compounds for APOH Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-D-Mannose
3458-28-4 target

(89) Novoseek inferred chemical compound relationships for APOH Gene

Compound -log(P) Hits PubMed IDs
cardiolipin 92.7 121
phospholipid 75.5 99
aspirin 67 29
phosphatidylserine 63.4 22
warfarin 62.4 3
genes like me logo Genes that share compounds with APOH: view

Transcripts for APOH Gene

mRNA/cDNA for APOH Gene

Unigene Clusters for APOH Gene

Apolipoprotein H (beta-2-glycoprotein I):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APOH

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for APOH Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:
SP2:

Relevant External Links for APOH Gene

GeneLoc Exon Structure for
APOH
ECgene alternative splicing isoforms for
APOH

Expression for APOH Gene

mRNA expression in normal human tissues for APOH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for APOH Gene

This gene is overexpressed in Liver (52.6).

Protein differential expression in normal tissues for APOH Gene

This gene is overexpressed in Serum (21.7), Plasma (9.3), and Vitreous humor (7.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for APOH Gene

SOURCE GeneReport for Unigene cluster for APOH Gene Hs.445358

mRNA Expression by UniProt/SwissProt for APOH Gene

P02749-APOH_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma
genes like me logo Genes that share expressions with APOH: view

Expression partners for APOH Gene

In Situ Assay Products

Orthologs for APOH Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOH Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia APOH 35
  • 80.97 (n)
  • 81.16 (a)
APOH 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia APOH 35
  • 86.67 (n)
  • 81.74 (a)
APOH 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Apoh 35
  • 78.36 (n)
  • 76.52 (a)
Apoh 16
Apoh 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia APOH 35
  • 99.52 (n)
  • 99.42 (a)
APOH 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Apoh 35
  • 81.16 (n)
  • 82.32 (a)
oppossum
(Monodelphis domestica)
Mammalia APOH 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia APOH 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves APOH 35
  • 56.85 (n)
  • 46.06 (a)
APOH 36
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 44 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 5 (a)
OneToMany
Species with no ortholog for APOH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for APOH Gene

ENSEMBL:
Gene Tree for APOH (if available)
TreeFam:
Gene Tree for APOH (if available)

Paralogs for APOH Gene

Paralogs for APOH Gene

Selected SIMAP similar genes for APOH Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with APOH: view

Variants for APOH Gene

Sequence variations from dbSNP and Humsavar for APOH Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs666 -- 66,228,153(-) GTCCC(A/G)TTAAA synonymous-codon, reference
rs4581 Benign, - 66,214,639(-) GTAAA(G/T)TACCT reference, missense
rs6933 -- 66,212,112(-) CCACA(C/T)AAAAT utr-variant-3-prime
rs12544 -- 66,226,094(-) CTTAG(A/G)AAATG reference, missense
rs1544556 -- 66,214,410(-) TTGCC(C/T)GTCAT intron-variant

Relevant External Links for APOH Gene

HapMap Linkage Disequilibrium report
APOH
Human Gene Mutation Database (HGMD)
APOH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for APOH Gene

Disorders for APOH Gene

(96) Novoseek inferred disease relationships for APOH Gene

Disease -log(P) Hits PubMed IDs
antiphospholipid syndrome 97.6 150
lupus erythematosus systemic 92.2 169
thrombosis 90.2 153
miscarriage recurrent 88.1 65
arterial thrombosis 86.4 41

Genatlas disease for APOH Gene

deficiency of production of apo-H dependent antiphospholipid autoantibody

Relevant External Links for APOH

Genetic Association Database (GAD)
APOH
Human Genome Epidemiology (HuGE) Navigator
APOH
genes like me logo Genes that share disorders with APOH: view

No data available for OMIM and UniProtKB/Swiss-Prot for APOH Gene

Publications for APOH Gene

  1. Molecular definition of human beta 2-glycoprotein I (beta 2-GPI) by cDNA cloning and inter-species differences of beta 2-GPI in alternation of anticardiolipin binding. (PMID: 1777418) Matsuura E. … Koike T. (Int. Immunol. 1991) 3 4 23
  2. Activity, disulphide mapping and structural modelling of the fifth domain of human beta 2-glycoprotein I. (PMID: 1426288) Steinkkasserer A. … Norman D.G. (FEBS Lett. 1992) 3 4 23
  3. Molecular cloning and sequence analysis of the cDNA encoding human apolipoprotein H (beta 2-glycoprotein I). (PMID: 1339416) Day J.R. … Arnaud P. (Int. J. Clin. Lab. Res. 1992) 3 4 23
  4. Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor. (PMID: 1602135) Matsuura E. … Koike T. (J. Immunol. 1992) 3 4 23
  5. Assignment of apolipoprotein H (APOH: beta-2-glycoprotein I) to human chromosome 17q23----qter; determination of the major expression site. (PMID: 1582254) Steinkasserer A. … Sim R.B. (Cytogenet. Cell Genet. 1992) 2 3 23

Products for APOH Gene

  • Addgene plasmids for APOH

Sources for APOH Gene

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