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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

APOH Gene

protein-coding GIFtS: 65
GCID: GC17M064208

apolipoprotein H (beta-2-glycoprotein I)

(Previous symbol: B2G1)

Explore 215 diseases affiliated with
APOH via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Apolipoprotein H (Beta-2-Glycoprotein I)¹ ²		Apo-H³
B2G1¹ ² ³		Beta(2)GPI³
BG¹ ²		Beta-2-Glycoprotein 1²
Activated Protein C-Binding Protein² ³		Apo-H³
Anticardiolipin Cofactor² ³		Beta(2)GPI³
B2GPI² ³		Apolipoprotein H³
APC Inhibitor² ³		Beta-2-Glycoprotein I³
B2GP1²

External Ids:	HGNC: 616¹	Entrez Gene: 350²	Ensembl: ENSG00000091583⁷	OMIM: 138700⁵	UniProtKB: P02749³

Export aliases for APOH gene to outside databases

Previous GC identifers: GC17P064187 GC17P067253 GC17M064625 GC17M064758 GC17M061638 GC17M059599

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for APOH:

Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism,

coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic

phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary

antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies

associated with infections. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: APOH_HUMAN, P02749

Function: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate.

May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of

damaged cells

Gene Wiki entry for APOH (Apolipoprotein H)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the APOH gene promoter:
SRF C/EBPbeta RFX1 POU2F1 SRF (504 AA) POU2F1a POU3F2 Evi-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: APOH promoter sequence

Search SABiosciences Chromatin IP Primers for APOH

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOH

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24.2 Ensembl cytogenetic band: 17q24.2 HGNC cytogenetic band: 17q24.2

APOH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOH gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M064208: view genomic region (about GC identifiers)

Start:	64,208,147 bp from pter	End:	64,252,643 bp from pter
Size:	44,497 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: APOH_HUMAN, P02749 (See protein sequence)

Recommended Name: Beta-2-glycoprotein 1 precursor

Size: 345 amino acids; 38298 Da

Subcellular location: Secreted

6 PDB 3D structures from and Proteopedia for APOH:

1C1Z (3D)

1G4F (3D)

1G4G (3D)

1QUB (3D)

2KRI (3D)

3OP8 (3D)

Secondary accessions: B2R9M3 Q9UCN7

Explore the universe of human proteins at neXtProt for APOH: NX_P02749

Post-translational modifications:

N- and O-glycosylated. PubMed:6587378 also reports glycosylation on 'Asn-188' for their allele¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P02749

APOH Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000033.2

ENSEMBL proteins:

ENSP00000205948 ENSP00000462260 ENSP00000463553 ENSP00000464301

Human Recombinant Protein Products:

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	Sino Biological Recombinant Protein for APOH
	ProSpec Recombinant Protein for APOH
	Uscn Proteins for APOH

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IDA	--
GO:0009986	cell surface	IDA	16480936
GO:0031012	colocalizes with extracellular matrix	IDA	--
GO:0034361	very-low-density lipoprotein particle	IDA	222615
GO:0034364	high-density lipoprotein particle	IDA	222615

APOH for ontologies About GeneDecksing

APOH Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of APOH
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	Novus Biologicals APOH Antibodies
	Abcam antibodies for APOH
	Uscn Antibodies for APOH
	ThermoFisher Antibodies for APOH

Assay Products for APOH:

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	GenScript Custom Assay Services for APOH
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for APOH

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

APOH for domains About GeneDecksing

2 InterPro domains/families:

IPR015104 Sushi_2

IPR000436 Sushi_SCR_CCP

Graphical View of Domain Structure for InterPro Entry P02749

ProtoNet protein and cluster: P02749

1 Blocks protein family: IPB000436 Sushi domain/SCR domain/CCP module

UniProtKB/Swiss-Prot: APOH_HUMAN, P02749

Similarity: Contains 4 Sushi (CCP/SCR) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: APOH_HUMAN, P02749

Function: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate.

May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of

damaged cells

Genatlas biochemistry entry for APOH:

apolipoprotein H (beta-2-glycoprotein I),precursor activator of lipoprotein lipase,cofactor for the binding of

antianionic phospholipid autoantibodies

miRNA Products:		OriGene 3'-UTR Clone: APOH Browse MicroRNA Expression Plasmids
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for APOH

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for APOH
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOH

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001948	glycoprotein binding	IPI	9269765
GO:0005515	protein binding	IPI	16480936
GO:0005543	phospholipid binding	IDA	15486070
GO:0008201	heparin binding	IEA	--
GO:0008289	lipid binding	IDA	222615

APOH for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Apoh^tm1Krl for APOH
     2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Apoh):

homeostasis/metabolism

mortality/aging

APOH for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Selected targets of HNF1

Selected targets of HNF1

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for APOH

Selected targets of HNF1

APOH for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for APOH

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

5/17 Interacting proteins for APOH (P02749^{2, 3} ENSP00000205948⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ANXA2	P07355³, ENSP00000346032⁴	I2D: score=2 STRING: ENSP00000346032
CLEC4G	Q6UXB4³, ENSP00000327599⁴	I2D: score=2 STRING: ENSP00000327599
GEM	P55040³, ENSP00000297596⁴	I2D: score=2 STRING: ENSP00000297596
LPA	P08519³, ENSP00000321334⁴	I2D: score=2 STRING: ENSP00000321334
LRP2	P98164³, ENSP00000263816⁴	I2D: score=2 STRING: ENSP00000263816

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001937	negative regulation of endothelial cell proliferation	IDA	17872974
GO:0006641	triglyceride metabolic process	IDA	7417307
GO:0007596	blood coagulation	--	--
GO:0007597	blood coagulation, intrinsic pathway	IDA	4052628
GO:0010596	negative regulation of endothelial cell migration	IDA	17872974

APOH for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

APOH for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for APOH

10/94 HMDB Compounds for APOH (see all 94) About this table

Compound	Synonyms	CAS #	PubMed Ids
CL(18:1(11Z)/18:1(11Z)/18:1(11Z)/18:1(11Z))	Cardiolipins(72:4) (see all 14)	--	--
CL(18:1(11Z)/18:1(11Z)/18:1(11Z)/18:2(9Z,12Z))	Cardiolipins(72:4) (see all 14)	--	--
CL(18:1(9Z)/18:1(9Z)/18:1(9Z)/18:1(9Z))	Cardiolipin(18:1n9/18:1n9/18:1n9/18:1n9) (see all 14)	--	--
CL(18:1(9Z)/18:1(9Z)/18:1(9Z)/18:2(9Z,12Z))	Cardiolipin(18:1n9/18:1n9/18:1n9/18:1n9) (see all 14)	--	--
CL(18:2(9Z,12Z)/18:1(11Z)/18:1(11Z)/16:0)	Cardiolipins(72:5) (see all 14)	--	--
CL(18:2(9Z,12Z)/18:1(11Z)/18:1(11Z)/16:1(9Z))	Cardiolipins(72:5) (see all 14)	--	--
CL(18:2(9Z,12Z)/18:1(11Z)/18:1(9Z)/16:0)	Cardiolipins(72:5) (see all 14)	--	--
CL(18:2(9Z,12Z)/18:1(11Z)/18:1(9Z)/16:1(9Z))	Cardiolipins(72:5) (see all 14)	--	--
CL(18:2(9Z,12Z)/18:1(9Z)/18:1(11Z)/16:0)	Cardiolipins(72:5) (see all 14)	--	--
CL(18:2(9Z,12Z)/18:1(9Z)/18:1(11Z)/16:1(9Z))	Cardiolipins(72:5) (see all 14)	--	--

1 DrugBank Compound for APOH About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Alpha-D-Mannose	--	3458-28-4	target	--	--

10/89 Novoseek chemical compound relationships for APOH gene (see all 89) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cardiolipin	92.7	203	7646462 (5), 1972485 (3), 7586693 (3), 1491401 (3) (see all 99)
phospholipid	75.5	132	9761718 (3), 9814664 (3), 8115986 (2), 17311864 (2) (see all 84)
aspirin	67	33	8984925 (2), 1415304 (2), 9381258 (1), 15846729 (1) (see all 27)
phosphatidylserine	63.4	33	1972485 (2), 10684648 (2), 9063752 (2), 9083311 (1) (see all 19)
warfarin	62.4	4	8457098 (1), 14728051 (1), 10973677 (1)
heparin	62	35	8362374 (2), 7878636 (2), 18307901 (2), 8457098 (1) (see all 28)
homocysteine	55	50	12756475 (1), 16601831 (1), 17116831 (1), 17911191 (1) (see all 45)
phosphatidylethanolamine	46.9	11	1491401 (2), 9083311 (1), 8926568 (1), 8025204 (1) (see all 8)
fibrinogen	45.3	33	1815761 (1), 8989971 (1), 9812085 (1), 10726007 (1) (see all 31)
hydroxychloroquine	41.6	1	16623930 (1)

Search CenterWatch for drugs/clinical trials and news about APOH

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for APOH gene:

NM_000042.2

Unigene Cluster for APOH:

Apolipoprotein H (beta-2-glycoprotein I)

Hs.445358 [show with all ESTs]

Unigene Representative Sequence: NM_000042

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000205948(uc002jfn.4) ENST00000585162 ENST00000581797 ENST00000577982

miRNA Products:		OriGene 3'-UTR Clone: APOH Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APOH
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APOH

Additional cDNA sequence:

AF082883.1 AK298416.1 AK313838.1 BC020703.1 BC026283.1 HM212425.1 M62839.1 S80305.1

X53595.1 X57847.1 X58100.1

15 DOTS entries:

DT.451558 DT.100826207 DT.120969768 DT.100826210 DT.91771189 DT.91771176 DT.120969757 DT.120969758

DT.91771187 DT.100826208 DT.120969766 DT.91771196 DT.95298244 DT.95298256 DT.99966864

24/499 AceView cDNA sequences (see all 499):

CR595640 BC026283 T28607 CB158455 BX495112 BG566874 AV655448 AV654503

BM311916 AV647767 W92730 AV650590 BU078887 BG569487 T40190 AW014874

BM505272 AV649793 CB158470 BU072922 CB120394 AV648562 CB158477 CB122980

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for APOH About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8
SP1:
SP2:

ECgene alternative splicing isoforms for APOH

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

APOH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTAAGGTGGT

About this image

APOH expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Beating cell clusters (Spontaneous differen...)

See APOH Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for APOH

SOURCE GeneReport for Unigene cluster: Hs.445358

UniProtKB/Swiss-Prot: APOH_HUMAN, P02749

Tissue specificity: Expressed by the liver and secreted in plasma

SABiosciences Expression via Pathway-Focused PCR Array including APOH:

Cell Lineage Identification in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOH

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for APOH gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	APOH¹	apolipoprotein H (beta-2-glycoprotein I)	56.46(n) 46.36(a)		417431 XM_415683.3 XP_415683.2
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	45(a) 43(a) (see all 3)	1 ↔ many 1 ↔ many (see all 3)	GL343260.1(384781-396311) GL343260.1(401132-410514)
zebrafish (Danio rerio)	Actinopterygii	CR352286.1⁶ CR759867.1⁶ (see all 5)	--	(see all 5)	possible ortholog possible ortholog (see all 5)	19(45874989-46606132) 19(45630467-45650934)
worm (Caenorhabditis elegans)	Secernentea	T07H6.4⁶	Protein T07H6.4	7(a)	possible ortholog	X(6281881-6286136)

ENSEMBL Gene Tree for APOH (if available)
TreeFam Gene Tree for APOH (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for APOH gene

F13B² CFHR4² CFHR5² CFHR2² CFH² CFHR3² CFHR1²

APOH for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs4581^1,2	C,F,H,	non-pathogenic	64210757(-)	`GTAAAC/G/TTACCT`	3	L V	mis¹		49		EA NS NA WA CSA EU	11809
rs192708662^1,2		--	64207681(+)	`TTGTTG/TGTTTG`	1	--	ds500¹		0	--	--	--	--
rs8178865^1,2	C,	--	64207682(-)	`acaaaC/GAAACA`	1	--	ds500¹		3		NS NA	92
rs150837470^1,2	C,	--	64207695(+)	`GTTTG-/TTTA TTTAT`	1	--	ds500¹		0	--	--	--	--
rs7216713^1,2	C,A,H,	--	64207698(+)	`TGTTTG/ATTTAT`	1	--	ds500¹		5		NA WA	12
rs79229348^1,2		--	64207702(+)	`TATTTA/GTTTAT`	1	--	ds500¹		0	--	--	--	--
rs147117777^1,2		--	64207731(+)	`ACTCTA/GTCGCC`	1	--	ds500¹		0	--	--	--	--
rs184865767^1,2		--	64207796(+)	`TTCAAC/GCAATT`	1	--	ds500¹		0	--	--	--	--
rs8178864^1,2	C,F,A,H,	--	64207851(-)	`tgggcA/Gtggtg`	1	--	ds500¹		2		NS	90
rs8178863^1,2	C,F,	--	64207974(-)	`ctcacG/Acctgt`	1	--	ds500¹		2		NS	90

HapMap Linkage Disequilibrium report for APOH (64208147 - 64252643 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for APOH: --
Human Gene Mutation Database (HGMD): APOH

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing APOH

DNA2.0 Custom Variant and Variant Library Synthesis for APOH

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

APOH for disorders           About GeneDecksing

OMIM gene information: 138700    OMIM disorders: --

20/215 diseases for APOH (see all 215):    About MalaCards

antiphospholipid syndrome retinal vein occlusion central retinal vein occlusion factor xii deficiency

antithrombin iii deficiency severe pre-eclampsia connective tissue disease heparin-induced thrombocytopenia

mixed connective tissue disease deep vein thrombosis transient global amnesia pre-eclampsia

patent foramen ovale spinal cord infarction transverse myelitis nodular regenerative hyperplasia

thrombotic thrombocytopenic purpura thrombophlebitis retinal artery occlusion amaurosis fugax

6 diseases from the University of Copenhagen DISEASES database for APOH:

Antiphospholipid syndrome Systemic lupus erythematosus Syphilis Thrombocytopenia

Vascular disease Thrombophilia

10/96 Novoseek disease relationships for APOH gene (see all 96) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
antiphospholipid syndrome	97.6	500	7686561 (4), 1506982 (3), 8608682 (3), 9077618 (3) (see all 99)
lupus erythematosus systemic	92.2	357	9796352 (4), 9491201 (3), 8303111 (3), 1553941 (3) (see all 99)
thrombosis	90.2	349	12393574 (7), 1497015 (5), 1418145 (5), 8170264 (4) (see all 99)
miscarriage recurrent	88.1	71	9207584 (3), 12596957 (3), 2283959 (2), 8567830 (2) (see all 53)
arterial thrombosis	86.4	44	10870856 (3), 11092466 (3), 9333316 (2), 1398731 (1) (see all 36)
pregnancy loss	85.4	74	1498338 (4), 9083311 (4), 18307901 (4), 8375525 (4) (see all 51)
venous thrombosis	84.4	83	1443986 (6), 16409447 (4), 7781279 (3), 8170264 (2) (see all 62)
thrombophilia	83.4	49	8621985 (2), 11697706 (1), 11843372 (1), 15919499 (1) (see all 46)
apc resistance	83.2	48	14982257 (2), 8841318 (2), 7578527 (1), 11108774 (1) (see all 46)
miscarriage	81.5	99	1633897 (5), 8305382 (4), 7675379 (4), 9806576 (3) (see all 66)

Genatlas disease: APOH

deficiency of production of apo-H dependent antiphospholipid autoantibody

Genetic Association Database (GAD): APOH
Human Genome Epidemiology (HuGE) Navigator: APOH (30 documents)

Export disorders for APOH gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for APOH gene, integrated from 9 sources (see all 1763):
(articles sorted by number of sources associating them with APOH)

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world of online information

Nucleotide sequence and expression of the human gene encoding apolipoprotein H (beta 2-glycoprotein I). (PubMed id 1748314)^{1, 2, 9} Mehdi H....Peeples M.E. (1991)
Identification of structural mutations in the fifth domain of apolipoprotein H (beta-2-glycoprotein I) which affect phospholipid binding. (PubMed id 9063752)^{1, 2, 9} Sanghera D.K.... Kamboh M.I. (1997)
Assignment of apolipoprotein H (APOH: beta-2-glycoprotein I) to human chromosome 17q23----qter; determination of the major expression site. (PubMed id 1582254)^{1, 3, 9} Steinkasserer A....Sim R.B. (1992)
Molecular basis of the apolipoprotein H (beta 2-glycoprotein I) protein polymorphism. (PubMed id 9225969)^{1, 2, 9} Sanghera D.K.... Kamboh M.I. (1997)
Molecular cloning and sequence analysis of the cDNA encoding human apolipoprotein H (beta 2-glycoprotein I). (PubMed id 1339416)^{1, 2, 9} Day J.R.... Arnaud P. (1992)
Apolipoprotein H genetic variability in the population of Krk Island, Croatia. (PubMed id 12371681)^{1, 4, 9} Vitale K....Smolej-Narancic N. (2002)
[The relationship of apolipoprotein H gene polymorphism with stroke] (PubMed id 12887738)^{1, 4, 9} Xia J....Zhang L. (2003)
Apolipoprotein E and H polymorphisms in Mongolian Buryat: allele frequencies and relationship with plasma lipid levels. (PubMed id 12495080)^{1, 4, 9} Tsunoda K....Sato K. (2002)
Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor. (PubMed id 1602135)^{1, 2, 9} Matsuura E.... Koike T. (1992)
Apolipoprotein H gene polymorphisms and risk of primary cerebral hemorrhage in a Chinese population. (PubMed id 14707422)^{1, 4, 9} Xia J....Cao G.F. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 350	HGNC: 616	AceView: APOH	Ensembl:ENSG00000091583	euGenes: HUgn350
ECgene: APOH	H-InvDB: APOH

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for APOH	Pharmacogenomics, SNPs, Pathways
SeattleSNPs	http://pga.gs.washington.edu/data/apoh/
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=APOH

Intellectual Property for APOH gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for APOH gene:
Search GeneIP for patents involving APOH

Licensable Technologies for APOH gene:

Weizmann Institute:

Novel therapy for antiphospholipid syndrome based on b2GPI (beta-2-glycoprotein-I) corresponding synthetic peptides

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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APOH Gene

apolipoprotein H (beta-2-glycoprotein I)

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Pregnancy loss
Nephritis
Migraine
Collagen Diseases
Fetal Resorption
Raynauds Phenomenon
cns lupus
involvement CNS
Anemia Hemolytic
coagulopathy
Gangrene
Acrocyanosis
Amaurosis
Antithrombin III Deficiency
Atherosclerosis
Purpura Thrombotic Thrombocytopenic
Sjogrens Syndrome Primary
Deep vein thrombosis
Antiphospholipid Syndrome
Retinal Vein Occlusion
Rheumatic Diseases
Sneddon Syndrome
Thrombocytopenia
Hypocomplementemia
Cerebral Thrombosis
Miscarriage
Splenic Infarction
Cerebral Infarction
PARTIAL THROMBOPLASTIN TIME PROLONGED
ARTERIAL THROMBOSIS
Retinal Thrombosis
Protein C Deficiency
Transient Ischemic Attack
Factor XII Deficiency
Retinal Artery Occlusion
Proteinuria
BUERGER DISEASE
Hyperhomocysteinemia
Retinal vasculitis
Lupus Erythematosus
Superficial thrombophlebitis
Rheumatoid Arthritis
Severe pre-eclampsia
Lupoid Sclerosis
HELLP Syndrome
Thrombosis
CEREBRAL VENOUS THROMBOSIS
Autoimmunity
Sinus Thrombosis
Preeclampsia
Retinal vascular occlusion
Budd-Chiari Syndrome
Valvular Heart Diseases
THROMBOPHLEBITIS MIGRATORY
APC Resistance
Autoimmune Diseases
Vasculitis
Venous Thrombosis
Placental infarction
INFARCT
Arteriovenous fistula thrombosis
Mixed Connective Tissue Disease
Intrauterine death
Obstetrical Complication
Other connective tissue disease
Serositis
Miscarriage Recurrent
Myelitis Transverse
Sjogrens Syndrome
DEGOS DISEASE
Intrauterine Growth Retardation
Connective Tissue Diseases
Cryoglobulinemia
Hypoprothrombinemias
Lupus Erythematosus Discoid
ADRENAL HEMORRHAGE
Protein S Deficiency
Sjogrens Syndrome Secondary
Stillbirth
Thromboembolism Pulmonary
BEHCET DISEASE
Hepatic infarction
Syphilis
Thrombophilia
STROKE
Lupus erythematodes
Vascular Diseases
Lupus Nephritis
Central retinal vein occlusion
CEREBROVASCULAR DISEASE
Pulmonary Embolism
Sclerosis Systemic
Pregnancy Complications
Lupus Erythematosus Systemic
Thromboembolism
Thrombophlebitis

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APOH Gene

apolipoprotein H (beta-2-glycoprotein I)

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