APOF Gene

Aliases
for APOF gene

Previous GC identifers: GC12P056570 GC12P056542 GC12M056471 GC12M055040 GC12M055010 GC12M053793

Summaries
for APOF gene

Genomic Views
for APOF gene

RefSeq DNA sequence:

NC_000012.11  NC_018923.1  NT_029419.12  

SwitchGear Promoter luciferase reporter plasmid: APOF promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOF

APOF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M056754:  view genomic region     (about GC identifiers)

Proteins
for APOF gene

Explore the universe of human proteins at neXtProt for APOF: NX_Q13790

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: APOF OriGene Custom Protein Services for APOF
	GenScript Custom Purified and Recombinant Proteins Services for APOF
	Novus Biologicals APOF Protein Novus Biologicals APOF Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for APOF

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 3): APOF OriGene Custom Antibody Services for APOF
	GenScript Superior Antibodies for APOF
	Novus Biologicals APOF Antibodies
	Abcam antibodies for APOF
	Uscn Antibodies for APOF
	ThermoFisher Antibodies for APOF

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for APOF
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for APOF

Protein Domains /
Families
for APOF gene

ProtoNet protein and cluster: Q13790

Function
for APOF gene

miRNA Products:		OriGene 3'-UTR Clone: APOF Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APOF
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate APOF:
		hsa-miR-409-5p hsa-miR-570
		SwitchGear 3'UTR luciferase reporter plasmid: APOF 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APOF (see all 7) OriGene shRNA RFP: APOF OriGene siRNA: APOF
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APOF

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for APOF

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APOF (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APOF (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: APOF (NM_001638)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for APOF
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOF

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for APOF
		Search LifeMap BioReagents cell lines for APOF

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOF

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Apof)

Pathways & Interactions
for APOF gene

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for APOF gene

Transcripts
for APOF gene

Expression
for APOF gene

APOF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTCAAAAAA

2 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BoneZeugopod Growth Plate			Bone
	LiverLiver Lobule			Liver
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Immature hepatocyte-like cells (Generation of hepato...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for APOF Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat APOF
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APOF
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APOF

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOF

Orthologs
for APOF gene

Paralogs
for APOF gene

Paralogs for APOF gene

APOF for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for APOF
PGOHUM00000239476 PGOHUM00000239478

Genomic Variants
for APOF gene

10/86 NCBI SNPs in APOF are shown (see all 86)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs20668131,2	C,F,H	--	56753870(-)	CATTGG/AAGGGC	3	--	ut51 int1		10		NA NS MN EA	1044
rs1428343711,2		--	56753993(+)	AAGTCC/TGGAGC	3	--	ut51 int1		0	--	--	--	--
rs115752221,2	C,F,	--	56753994(-)	CGCTCC/TGGACT	3	--	ut51 int1		1		NS	178
rs115752211,2	C,F,H,	--	56754137(-)	CGCTGA/CAGCTG	3	--	int1 us2k1		21		NS EA WA NA CSA	2254
rs1861783491,2		--	56754196(+)	ATTAGG/TGGACT	3	--	us2k1 int1		0	--	--	--	--
rs1906925881,2		--	56754243(+)	CGCGTA/GAGCCC	3	--	us2k1 int1		0	--	--	--	--
rs2000233511,2		--	56754371(+)	TTTTT-/TTATTTTT	3	--	us2k1 ut31		0	--	--	--	--
rs1115170481,2	C,	--	56754372(+)	TTTTT-/TATTTTT	3	--	ut31 us2k1		1		CSA	2
rs49963821,2	C,F,A,	--	56754466(-)	cacctG/Aagcct	3	--	ut31 us2k1 ese3		5		NS WA CSA NA	276
rs1834075831,2		--	56754475(+)	TGATTC/TTCCCG	3	--	ut31 us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for APOF (56754353 - 56756607 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for APOF
     1 CNV: 0164

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing APOF

DNA2.0 Custom Variant and Variant Library Synthesis for APOF

Disorders / Diseases
for APOF gene

Publications
for APOF gene

PubMed articles for APOF gene, integrated from 9 sources (see all 35): (articles sorted by number of sources associating them with APOF)

Utopia: connect your pdf to the dynamic world of online information

1. Purification and molecular cloning of human apolipoprotein F. (PubMed id 8093033)^{1, 2, 3, 9} Day J.R....Wolfbauer G. (1994)
2. Molecular cloning and expression of lipid transfer inhibitor protein reveals its identity with apolipoprotein F. (PubMed id 9880564)^{1, 2, 9} Wang X.... Morton R.E. (1999)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
4. Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population. (PubMed id 15172102)^{1, 4} Kabbara A....Lambert J.C. (2004)
5. Isolation and partial characterization of a new acidic apolipoprotein (apolipoprotein F) from high density lipoproteins of human plasma. (PubMed id 204339)^{1, 2} Olofsson S.-O.... Alaupovic P. (1978)
6. Control of cholesteryl ester transfer protein activity by sequestration of lipid transfer inhibitor protein in an inactive complex. (PubMed id 18369235)^{1, 9} He Y....Morton R.E. (2008)
7. Lipid transfer inhibitor protein defines the participation of high density lipoprotein subfractions in lipid transfer reactions mediated by cholesterol ester transfer protein (CETP). (PubMed id 12907677)^{1, 9} Paromov V.M. and Morton R.E. (2003)
8. Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD. (PubMed id 22171320)² Halim A.... Larson G. (2011)
9. Conversion of lipid transfer inhibitor protein (apolip oprotein F) to its active form depends on LDL composition. (PubMed id 21937674)¹ Morton R.E. and Greene D.J. (2011)
10. Common genetic variation in multiple metabolic pathwa ys influences susceptibility to low HDL-cholesterol and coronary heart disease. (PubMed id 20855565)¹ Peloso G.M....Brousseau M.E. (2010)

External Searches for APOF gene

Genome Databases showing APOF gene

Other Databases showing APOF gene

Specialized Databases showing APOF gene

Products
for APOF gene