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Aliases for APOF Gene

Aliases for APOF Gene

  • Apolipoprotein F 2 3 5
  • Lipid Transfer Inhibitor Protein 3 4
  • Apo-F 3 4
  • LTIP 3 4

External Ids for APOF Gene

Previous GeneCards Identifiers for APOF Gene

  • GC12P056570
  • GC12P056542
  • GC12M056471
  • GC12M055040
  • GC12M055010
  • GC12M056754
  • GC12M053793

Summaries for APOF Gene

Entrez Gene Summary for APOF Gene

  • The product of this gene is one of the minor apolipoproteins found in plasma. This protein forms complexes with lipoproteins and may be involved in transport and/or esterification of cholesterol. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOF Gene

APOF (Apolipoprotein F) is a Protein Coding gene. Among its related pathways are Metabolism and Lipoprotein metabolism. GO annotations related to this gene include receptor binding and lipid transporter activity.

UniProtKB/Swiss-Prot for APOF Gene

  • Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII.

Gene Wiki entry for APOF Gene

Additional gene information for APOF Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOF Gene

Genomics for APOF Gene

Regulatory Elements for APOF Gene

Enhancers for APOF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H056768 0.8 FANTOM5 39.6 -405.8 -405846 0 FOXA2 TAF1 MAX CEBPG RAD21 YY1 IRF9 CTBP1 GATA3 GATAD2A APOF HSD17B6 RDH16 SPRYD4 GLS2 GPR182 NACA MYO1A PAN2 PIR51277
GH12H056564 1.2 Ensembl ENCODE 9.9 -205.4 -205387 7 HDAC1 ELF3 ARID4B BATF RFX5 RARA SCRT2 ATF7 RUNX3 IKZF2 RBMS2 GLS2 BAZ2A SPRYD4 APOF ATP5B SNORD59A SNORD59B NACA GC12P056589
GH12H056447 1.1 ENCODE 10.3 -86.2 -86244 2 HDGF MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF207 STAT2 NEMP1 BAZ2A PYM1 RN7SL809P GLS2 DNAJC14 APOF RBMS2 TIMELESS
GH12H056593 1.1 Ensembl ENCODE 10.3 -231.5 -231455 1 PKNOX1 ATF1 RB1 INSM2 SIN3A ZNF2 RAD21 ZEB1 ZNF143 EGR2 BAZ2A GLS2 RBMS2 SPRYD4 APOF STAT2 NACA PTGES3 GC12P056593 GC12P056594
GH12H056291 0.7 ENCODE 10.1 +71.2 71214 1 PKNOX1 NFIB CTBP1 GATA3 SCRT2 FOSL2 FOS ZNF600 TCF7L2 SCRT1 COQ10A ANKRD52 SLC39A5 RNF41 NABP2 PAN2 IL23A APOF GC12P056293 GC12M056288
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around APOF on UCSC Golden Path with GeneCards custom track

Genomic Location for APOF Gene

Chromosome:
12
Start:
56,360,569 bp from pter
End:
56,362,823 bp from pter
Size:
2,255 bases
Orientation:
Minus strand

Genomic View for APOF Gene

Genes around APOF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOF Gene

Proteins for APOF Gene

  • Protein details for APOF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13790-APOF_HUMAN
    Recommended name:
    Apolipoprotein F
    Protein Accession:
    Q13790
    Secondary Accessions:
    • Q8TC13

    Protein attributes for APOF Gene

    Size:
    326 amino acids
    Molecular mass:
    35399 Da
    Quaternary structure:
    No Data Available

neXtProt entry for APOF Gene

Post-translational modifications for APOF Gene

  • O-glycosylated with core 1 or possibly core 8 glycans.
  • Glycosylation at posLast=118118 and posLast=274274
  • Modification sites at PhosphoSitePlus

Other Protein References for APOF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for APOF Gene

Domains & Families for APOF Gene

Gene Families for APOF Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for APOF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for APOF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with APOF: view

No data available for UniProtKB/Swiss-Prot for APOF Gene

Function for APOF Gene

Molecular function for APOF Gene

GENATLAS Biochemistry:
apoliprotein F,high density,29kDa,only expressed in liver
UniProtKB/Swiss-Prot Function:
Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII.

Phenotypes From GWAS Catalog for APOF Gene

Gene Ontology (GO) - Molecular Function for APOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 8093033
GO:0005319 lipid transporter activity TAS 6816269
GO:0015485 cholesterol binding TAS 6816269
genes like me logo Genes that share ontologies with APOF: view
genes like me logo Genes that share phenotypes with APOF: view

Animal Models for APOF Gene

MGI Knock Outs for APOF:
  • Apof tm1(KOMP)Vlcg

Animal Model Products

  • Taconic Biosciences Mouse Models for APOF

CRISPR Products

miRNA for APOF Gene

miRTarBase miRNAs that target APOF

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for APOF
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for APOF Gene

Localization for APOF Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for APOF gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 1
mitochondrion 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for APOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14718574
GO:0034362 low-density lipoprotein particle IEA --
GO:0034364 high-density lipoprotein particle IEA --
genes like me logo Genes that share ontologies with APOF: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for APOF Gene

Pathways & Interactions for APOF Gene

genes like me logo Genes that share pathways with APOF: view

Gene Ontology (GO) - Biological Process for APOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 8093033
GO:0006810 transport IEA --
GO:0006869 lipid transport TAS,IEA --
GO:0008202 steroid metabolic process IEA --
GO:0008203 cholesterol metabolic process TAS,IEA --
genes like me logo Genes that share ontologies with APOF: view

No data available for SIGNOR curated interactions for APOF Gene

Drugs & Compounds for APOF Gene

(2) Drugs for APOF Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for APOF Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with APOF: view

Transcripts for APOF Gene

mRNA/cDNA for APOF Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for APOF Gene

Apolipoprotein F:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for APOF
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for APOF Gene

No ASD Table

Relevant External Links for APOF Gene

GeneLoc Exon Structure for
APOF
ECgene alternative splicing isoforms for
APOF

Expression for APOF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for APOF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for APOF Gene

This gene is overexpressed in Liver (x52.6).

Protein differential expression in normal tissues from HIPED for APOF Gene

This gene is overexpressed in Serum (45.6) and Plasma (15.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for APOF Gene



NURSA nuclear receptor signaling pathways regulating expression of APOF Gene:

APOF

SOURCE GeneReport for Unigene cluster for APOF Gene:

Hs.534302

mRNA Expression by UniProt/SwissProt for APOF Gene:

Q13790-APOF_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma.

Evidence on tissue expression from TISSUES for APOF Gene

  • Liver(4.6)
  • Bone marrow(4)
genes like me logo Genes that share expression patterns with APOF: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for APOF Gene

Orthologs for APOF Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APOF 33 34
  • 99.18 (n)
dog
(Canis familiaris)
Mammalia APOF 33 34
  • 78.86 (n)
cow
(Bos Taurus)
Mammalia APOF 33 34
  • 77.96 (n)
rat
(Rattus norvegicus)
Mammalia Apof 33
  • 75.19 (n)
mouse
(Mus musculus)
Mammalia Apof 33 16 34
  • 73.27 (n)
lizard
(Anolis carolinensis)
Reptilia APOF 34
  • 33 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii apof 34
  • 19 (a)
OneToOne
Species where no ortholog for APOF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APOF Gene

ENSEMBL:
Gene Tree for APOF (if available)
TreeFam:
Gene Tree for APOF (if available)

Paralogs for APOF Gene

Pseudogenes.org Pseudogenes for APOF Gene

genes like me logo Genes that share paralogs with APOF: view

No data available for Paralogs for APOF Gene

Variants for APOF Gene

Sequence variations from dbSNP and Humsavar for APOF Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000164732 -- 56,362,395(+) CTCGA(A/G)GGATC intron-variant
rs1001228611 -- 56,362,101(+) GTGGC(A/G)TCCAC upstream-variant-2KB, reference, synonymous-codon
rs1001243556 -- 56,364,673(+) GAATC(A/T)CAAGG upstream-variant-2KB
rs1001608340 -- 56,361,604(+) TAGCA(C/T)AATAC upstream-variant-2KB, reference, missense
rs1001619806 -- 56,361,975(+) ATGTG(A/G)CTGAA upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for APOF Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV gain+loss 15286789

Variation tolerance for APOF Gene

Residual Variation Intolerance Score: 73.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.53; 72.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for APOF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
APOF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOF Gene

Disorders for APOF Gene

Relevant External Links for APOF

Genetic Association Database (GAD)
APOF
Human Genome Epidemiology (HuGE) Navigator
APOF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APOF

No disorders were found for APOF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APOF Gene

Publications for APOF Gene

  1. Purification and molecular cloning of human apolipoprotein F. (PMID: 8093033) Day JR … Wolfbauer G (Biochemical and biophysical research communications 1994) 2 3 4 22 60
  2. Molecular cloning and expression of lipid transfer inhibitor protein reveals its identity with apolipoprotein F. (PMID: 9880564) Wang X … Morton RE (The Journal of biological chemistry 1999) 3 4 22 60
  3. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) Ruaño G … Wu AH (Pharmacogenomics 2010) 3 45 60
  4. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 45 60
  5. Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease. (PMID: 20855565) Peloso GM … Brousseau ME (Journal of lipid research 2010) 3 45 60

Products for APOF Gene

Sources for APOF Gene

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