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Aliases for APOF Gene

Aliases for APOF Gene

  • Apolipoprotein F 2 3
  • LTIP 3 4 6
  • Lipid Transfer Inhibitor Protein 3 4
  • Apo-F 3 4

External Ids for APOF Gene

Summaries for APOF Gene

Entrez Gene Summary for APOF Gene

  • The product of this gene is one of the minor apolipoproteins found in plasma. This protein forms complexes with lipoproteins and may be involved in transport and/or esterification of cholesterol. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOF Gene

APOF (Apolipoprotein F) is a Protein Coding gene. Diseases associated with APOF include dacryoadenitis. GO annotations related to this gene include receptor binding and lipid transporter activity.

UniProtKB/Swiss-Prot for APOF Gene

  • Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII.

Gene Wiki entry for APOF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOF Gene

Genomics for APOF Gene

Genomic Location for APOF Gene

Start:
56,360,569 bp from pter
End:
56,362,823 bp from pter
Size:
2,255 bases
Orientation:
Minus strand

Genomic View for APOF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APOF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOF Gene

Regulatory Elements for APOF Gene

Proteins for APOF Gene

  • Protein details for APOF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13790-APOF_HUMAN
    Recommended name:
    Apolipoprotein F
    Protein Accession:
    Q13790
    Secondary Accessions:
    • Q8TC13

    Protein attributes for APOF Gene

    Size:
    326 amino acids
    Molecular mass:
    35399 Da
    Quaternary structure:
    No Data Available

neXtProt entry for APOF Gene

Proteomics data for APOF Gene at MOPED

Post-translational modifications for APOF Gene

  • O-glycosylated with core 1 or possibly core 8 glycans.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn118 and Thr274

Other Protein References for APOF Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for APOF Gene

Domains for APOF Gene

Gene Families for APOF Gene

HGNC:

Protein Domains for APOF Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with APOF: view

No data available for UniProtKB/Swiss-Prot for APOF Gene

Function for APOF Gene

Molecular function for APOF Gene

GENATLAS Biochemistry: apoliprotein F,high density,29kDa,only expressed in liver
UniProtKB/Swiss-Prot Function: Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII.

Gene Ontology (GO) - Molecular Function for APOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 8093033
GO:0005319 lipid transporter activity TAS 6816269
GO:0015485 cholesterol binding TAS 6816269
genes like me logo Genes that share ontologies with APOF: view
genes like me logo Genes that share phenotypes with APOF: view

Animal Models for APOF Gene

MGI Knock Outs for APOF:
  • Apof tm1(KOMP)Vlcg

miRNA for APOF Gene

miRTarBase miRNAs that target APOF

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for APOF Gene

Localization for APOF Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOF Gene COMPARTMENTS Subcellular localization image for APOF gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 1
cytosol 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for APOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14718574
GO:0034362 low-density lipoprotein particle IEA --
GO:0034364 high-density lipoprotein particle IEA --
genes like me logo Genes that share ontologies with APOF: view

Pathways for APOF Gene

SuperPathways for APOF Gene

No Data Available

Interacting Proteins for APOF Gene

Gene Ontology (GO) - Biological Process for APOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 8093033
GO:0006641 triglyceride metabolic process IEA --
GO:0006869 lipid transport TAS 6816269
GO:0008203 cholesterol metabolic process IEA --
GO:0033344 cholesterol efflux IEA --
genes like me logo Genes that share ontologies with APOF: view

No data available for Pathways by source for APOF Gene

Compounds for APOF Gene

(4) Novoseek inferred chemical compound relationships for APOF Gene

Compound -log(P) Hits PubMed IDs
sodium oleate 79.3 2
oleic acid 62 9
lipid 51.1 31
cholesterol 25.8 10
genes like me logo Genes that share compounds with APOF: view

Transcripts for APOF Gene

mRNA/cDNA for APOF Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for APOF Gene

Apolipoprotein F:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APOF Gene

No ASD Table

Relevant External Links for APOF Gene

GeneLoc Exon Structure for
APOF
ECgene alternative splicing isoforms for
APOF

Expression for APOF Gene

mRNA expression in normal human tissues for APOF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for APOF Gene

This gene is overexpressed in Liver (52.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for APOF Gene

SOURCE GeneReport for Unigene cluster for APOF Gene Hs.534302

mRNA Expression by UniProt/SwissProt for APOF Gene

Q13790-APOF_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma.
genes like me logo Genes that share expressions with APOF: view

Orthologs for APOF Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APOF 36
  • 99.18 (n)
  • 98.77 (a)
APOF 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia APOF 36
  • 77.96 (n)
  • 64.82 (a)
APOF 37
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia APOF 36
  • 78.86 (n)
  • 68.84 (a)
APOF 37
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Apof 36
  • 73.27 (n)
  • 61.98 (a)
Apof 16
Apof 37
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Apof 36
  • 75.19 (n)
  • 66.79 (a)
lizard
(Anolis carolinensis)
Reptilia APOF 37
  • 33 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii apof 37
  • 19 (a)
OneToOne
Species with no ortholog for APOF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APOF Gene

ENSEMBL:
Gene Tree for APOF (if available)
TreeFam:
Gene Tree for APOF (if available)

Paralogs for APOF Gene

Pseudogenes.org Pseudogenes for APOF Gene

genes like me logo Genes that share paralogs with APOF: view

No data available for Paralogs for APOF Gene

Variants for APOF Gene

Sequence variations from dbSNP and Humsavar for APOF Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs7303708 -- 56,363,091(+) gagca(C/T)ggtgg upstream-variant-2KB
rs7953727 -- 56,363,209(+) AAAAA(A/T)AAATA upstream-variant-2KB
rs7953813 -- 56,363,211(+) AAAAA(A/T)ATATA upstream-variant-2KB
rs7953980 -- 56,363,401(+) AAAGG(A/G)GGGGA upstream-variant-2KB
rs10542211 -- 56,363,211(+) AAAAA(-/AA)TATAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for APOF Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV Complex 15286789

Relevant External Links for APOF Gene

HapMap Linkage Disequilibrium report
APOF

Disorders for APOF Gene

(1) MalaCards Diseases for APOF Gene

Search for APOF Gene in MalaCards »

(1) University of Copenhagen DISEASES for APOF Gene

Relevant External Links for APOF

Genetic Association Database (GAD)
APOF
Human Genome Epidemiology (HuGE) Navigator
APOF
genes like me logo Genes that share disorders with APOF: view

No data available for UniProtKB/Swiss-Prot for APOF Gene

Publications for APOF Gene

  1. Purification and molecular cloning of human apolipoprotein F. (PMID: 8093033) Day J.R. … Wolfbauer G. (Biochem. Biophys. Res. Commun. 1994) 2 3 4 23
  2. Molecular cloning and expression of lipid transfer inhibitor protein reveals its identity with apolipoprotein F. (PMID: 9880564) Wang X. … Morton R.E. (J. Biol. Chem. 1999) 3 4 23
  3. Lipid transfer inhibitor protein defines the participation of high density lipoprotein subfractions in lipid transfer reactions mediated by cholesterol ester transfer protein (CETP). (PMID: 12907677) Paromov V.M. … Morton R.E. (J. Biol. Chem. 2003) 3 23
  4. Control of cholesteryl ester transfer protein activity by sequestration of lipid transfer inhibitor protein in an inactive complex. (PMID: 18369235) He Y. … Morton R.E. (J. Lipid Res. 2008) 3 23
  5. Isolation and partial characterization of a new acidic apolipoprotein (apolipoprotein F) from high density lipoproteins of human plasma. (PMID: 204339) Olofsson S.-O. … Alaupovic P. (Biochemistry 1978) 3 4

Products for APOF Gene

Sources for APOF Gene

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