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Aliases for APOF Gene

Aliases for APOF Gene

  • Apolipoprotein F 2 3
  • Lipid Transfer Inhibitor Protein 3 4
  • Apo-F 3 4
  • LTIP 3 4

External Ids for APOF Gene

Previous GeneCards Identifiers for APOF Gene

  • GC12P056570
  • GC12P056542
  • GC12M056471
  • GC12M055040
  • GC12M055010
  • GC12M056754
  • GC12M053793

Summaries for APOF Gene

Entrez Gene Summary for APOF Gene

  • The product of this gene is one of the minor apolipoproteins found in plasma. This protein forms complexes with lipoproteins and may be involved in transport and/or esterification of cholesterol. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOF Gene

APOF (Apolipoprotein F) is a Protein Coding gene. Among its related pathways are Metabolism and Lipoprotein metabolism. GO annotations related to this gene include receptor binding and lipid transporter activity.

UniProtKB/Swiss-Prot for APOF Gene

  • Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII.

Gene Wiki entry for APOF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOF Gene

Genomics for APOF Gene

Regulatory Elements for APOF Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for APOF Gene

Chromosome:
12
Start:
56,360,569 bp from pter
End:
56,362,823 bp from pter
Size:
2,255 bases
Orientation:
Minus strand

Genomic View for APOF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APOF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOF Gene

Proteins for APOF Gene

  • Protein details for APOF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13790-APOF_HUMAN
    Recommended name:
    Apolipoprotein F
    Protein Accession:
    Q13790
    Secondary Accessions:
    • Q8TC13

    Protein attributes for APOF Gene

    Size:
    326 amino acids
    Molecular mass:
    35399 Da
    Quaternary structure:
    No Data Available

neXtProt entry for APOF Gene

Proteomics data for APOF Gene at MOPED

Post-translational modifications for APOF Gene

  • O-glycosylated with core 1 or possibly core 8 glycans.
  • Glycosylation at Asn 118 and Thr 274
  • Modification sites at PhosphoSitePlus

Other Protein References for APOF Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for APOF Gene

Domains & Families for APOF Gene

Gene Families for APOF Gene

Protein Domains for APOF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for APOF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with APOF: view

No data available for UniProtKB/Swiss-Prot for APOF Gene

Function for APOF Gene

Molecular function for APOF Gene

GENATLAS Biochemistry:
apoliprotein F,high density,29kDa,only expressed in liver
UniProtKB/Swiss-Prot Function:
Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII.

Gene Ontology (GO) - Molecular Function for APOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 8093033
GO:0005319 lipid transporter activity TAS 6816269
GO:0015485 cholesterol binding TAS 6816269
genes like me logo Genes that share ontologies with APOF: view

Phenotypes for APOF Gene

genes like me logo Genes that share phenotypes with APOF: view

Animal Models for APOF Gene

MGI Knock Outs for APOF:
  • Apof tm1(KOMP)Vlcg

Animal Model Products

miRNA for APOF Gene

miRTarBase miRNAs that target APOF

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APOF

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for APOF Gene

Localization for APOF Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOF Gene COMPARTMENTS Subcellular localization image for APOF gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for APOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14718574
GO:0034362 low-density lipoprotein particle IEA --
GO:0034364 high-density lipoprotein particle IEA --
genes like me logo Genes that share ontologies with APOF: view

Pathways & Interactions for APOF Gene

genes like me logo Genes that share pathways with APOF: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for APOF Gene

Gene Ontology (GO) - Biological Process for APOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 8093033
GO:0006869 lipid transport IEA --
GO:0008203 cholesterol metabolic process IEA --
genes like me logo Genes that share ontologies with APOF: view

No data available for SIGNOR curated interactions for APOF Gene

Drugs & Compounds for APOF Gene

(2) Drugs for APOF Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cholesterol Experimental Pharma Agonist 0
oleic acid Experimental Pharma Activation, Activator 0

(2) Additional Compounds for APOF Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LIPID
SODIUM OLEATE
genes like me logo Genes that share compounds with APOF: view

Transcripts for APOF Gene

mRNA/cDNA for APOF Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for APOF Gene

Apolipoprotein F:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APOF

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for APOF Gene

No ASD Table

Relevant External Links for APOF Gene

GeneLoc Exon Structure for
APOF
ECgene alternative splicing isoforms for
APOF

Expression for APOF Gene

mRNA expression in normal human tissues for APOF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for APOF Gene

This gene is overexpressed in Liver (x52.6).

Protein differential expression in normal tissues from HIPED for APOF Gene

This gene is overexpressed in Serum (45.6) and Plasma (15.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for APOF Gene



SOURCE GeneReport for Unigene cluster for APOF Gene Hs.534302

mRNA Expression by UniProt/SwissProt for APOF Gene

Q13790-APOF_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma.
genes like me logo Genes that share expression patterns with APOF: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for APOF Gene

Orthologs for APOF Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia APOF 35
  • 77.96 (n)
  • 64.82 (a)
APOF 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia APOF 35
  • 78.86 (n)
  • 68.84 (a)
APOF 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Apof 35
  • 73.27 (n)
  • 61.98 (a)
Apof 16
Apof 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia APOF 35
  • 99.18 (n)
  • 98.77 (a)
APOF 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Apof 35
  • 75.19 (n)
  • 66.79 (a)
lizard
(Anolis carolinensis)
Reptilia APOF 36
  • 33 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii apof 36
  • 19 (a)
OneToOne
Species with no ortholog for APOF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APOF Gene

ENSEMBL:
Gene Tree for APOF (if available)
TreeFam:
Gene Tree for APOF (if available)

Paralogs for APOF Gene

Pseudogenes.org Pseudogenes for APOF Gene

genes like me logo Genes that share paralogs with APOF: view

No data available for Paralogs for APOF Gene

Variants for APOF Gene

Sequence variations from dbSNP and Humsavar for APOF Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs7303708 -- 56,363,091(+) gagca(C/T)ggtgg upstream-variant-2KB
rs7953727 -- 56,363,209(+) AAAAA(A/T)AAATA upstream-variant-2KB
rs7953813 -- 56,363,211(+) AAAAA(A/T)ATATA upstream-variant-2KB
rs7953980 -- 56,363,401(+) AAAGG(A/G)GGGGA upstream-variant-2KB
rs10542211 -- 56,363,211(+) AAAAA(-/AA)TATAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for APOF Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV Complex 15286789

Variation tolerance for APOF Gene

Residual Variation Intolerance Score: 73.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.53; 72.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for APOF Gene

HapMap Linkage Disequilibrium report
APOF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOF Gene

Disorders for APOF Gene

Relevant External Links for APOF

Genetic Association Database (GAD)
APOF
Human Genome Epidemiology (HuGE) Navigator
APOF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APOF
genes like me logo Genes that share disorders with APOF: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APOF Gene

Publications for APOF Gene

  1. Purification and molecular cloning of human apolipoprotein F. (PMID: 8093033) Day J.R. … Wolfbauer G. (Biochem. Biophys. Res. Commun. 1994) 2 23 67
  2. Comparative proteomic profiling of plasma very-low-density and low-density lipoproteins. (PMID: 19945452) Sun H.Y. … Young K.C. (Clin. Chim. Acta 2010) 23 67
  3. Molecular cloning of hamster lipid transfer inhibitor protein (apolipoprotein F) and regulation of its expression by hyperlipidemia. (PMID: 19008550) Izem L. … Morton R.E. (J. Lipid Res. 2009) 23 67
  4. Altered expression of genes functioning in lipid homeostasis is associated with lipid deposition in NOD mouse lacrimal gland. (PMID: 19345210) Wu K. … Hamm-Alvarez S.F. (Exp. Eye Res. 2009) 23 67
  5. Overexpression of apolipoprotein F reduces HDL cholesterol levels in vivo. (PMID: 19008531) Lagor W.R. … Rader D.J. (Arterioscler. Thromb. Vasc. Biol. 2009) 23 67

Products for APOF Gene

Sources for APOF Gene

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