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APOF Gene(Protein Coding)

Apolipoprotein F

GCID:
GC12M056361
GIFtS:
54
Genes Participants
UDN Logo

Aliases for APOF Gene

Aliases for APOF Gene

  • Apolipoprotein F 2 3 5
  • Lipid Transfer Inhibitor Protein 3 4
  • Apo-F 3 4
  • LTIP 3 4

External Ids for APOF Gene

Previous GeneCards Identifiers for APOF Gene

  • GC12P056570
  • GC12P056542
  • GC12M056471
  • GC12M055040
  • GC12M055010
  • GC12M056754
  • GC12M053793

Summaries for APOF Gene

Entrez Gene Summary for APOF Gene

  • The product of this gene is one of the minor apolipoproteins found in plasma. This protein forms complexes with lipoproteins and may be involved in transport and/or esterification of cholesterol. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOF Gene

APOF (Apolipoprotein F) is a Protein Coding gene. Among its related pathways are Lipoprotein metabolism and Metabolism. GO annotations related to this gene include receptor binding and lipid transporter activity.

UniProtKB/Swiss-Prot for APOF Gene

  • Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII.

Gene Wiki entry for APOF Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOF Gene

Genomics for APOF Gene

Products:

  1. Regulatory Element

Regulatory Elements for APOF Gene

Enhancers for APOF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G056768 0.8 FANTOM5 39.6 -405.8 -405846 0.2 TAF1 MAX BMI1 CEBPG RAD21 YY1 IRF9 CTBP1 GATAD2A RFX1 APOF HSD17B6 RDH16 SPRYD4 GLS2 GPR182 NACA MYO1A PAN2 PIR51277
GH12G056593 1.3 Ensembl ENCODE 10.3 -231.5 -231455 1.8 HDGF PKNOX1 CREB3L1 ARNT SIN3A ZNF2 ZNF766 ZNF143 DEK REST BAZ2A ESYT1 GLS2 RBMS2 SPRYD4 APOF STAT2 CD63 NACA PTGES3
GH12G056564 1.2 Ensembl ENCODE 9.9 -205.4 -205387 7.7 ELF3 HDAC1 ARID4B RAD21 ZNF48 RARA SCRT2 FOS IKZF2 CEBPB RBMS2 GLS2 BAZ2A SPRYD4 APOF ATP5B SNORD59A SNORD59B NACA GC12P056589
GH12G056447 1.1 ENCODE 10.3 -86.2 -86244 2.3 HDGF MLX ARNT WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 STAT2 NEMP1 BAZ2A ENSG00000258199 RN7SL809P GLS2 APOF RBMS2 TIMELESS ENSG00000274569
GH12G056291 0.9 ENCODE 10.1 +71.2 71214 1.0 ELF3 HDGF PKNOX1 NFIB GLIS2 SCRT2 FOS ZNF391 ZNF548 SMARCA5 NEMP1 BAZ2A ENSG00000258317 COQ10A ANKRD52 RN7SL809P SLC39A5 NABP2 RNF41 PAN2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around APOF on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the APOF gene promoter:

Genomic Location for APOF Gene

Chromosome:
12
Start:
56,360,569 bp from pter
End:
56,362,823 bp from pter
Size:
2,255 bases
Orientation:
Minus strand

Genomic View for APOF Gene

Genes around APOF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOF Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for APOF Gene

Proteins for APOF Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for APOF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13790-APOF_HUMAN
    Recommended name:
    Apolipoprotein F
    Protein Accession:
    Q13790
    Secondary Accessions:
    • Q8TC13

    Protein attributes for APOF Gene

    Size:
    326 amino acids
    Molecular mass:
    35399 Da
    Quaternary structure:
    No Data Available

neXtProt entry for APOF Gene

Protein Expression for APOF Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for APOF Gene

  • O-glycosylated with core 1 or possibly core 8 glycans.
  • Glycosylation at Asn118 and Thr274
  • Modification sites at PhosphoSitePlus

Other Protein References for APOF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for APOF Gene

Domains & Families for APOF Gene

Gene Families for APOF Gene

HGNC:

Protein Domains for APOF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for APOF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with APOF: view

No data available for UniProtKB/Swiss-Prot for APOF Gene

Function for APOF Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for APOF Gene

GENATLAS Biochemistry:
apoliprotein F,high density,29kDa,only expressed in liver
UniProtKB/Swiss-Prot Function:
Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII.

Gene Ontology (GO) - Molecular Function for APOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 8093033
GO:0005319 lipid transporter activity TAS 6816269
GO:0015485 cholesterol binding TAS 6816269
genes like me logo Genes that share ontologies with APOF: view
genes like me logo Genes that share phenotypes with APOF: view

Animal Models for APOF Gene

MGI Knock Outs for APOF:
  • Apof tm1(KOMP)Vlcg
  • Apof tm1.1(KOMP)Vlcg

Animal Model Products

  • Taconic Biosciences Mouse Models for APOF

CRISPR Products

miRNA for APOF Gene

miRTarBase miRNAs that target APOF

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for APOF Gene

Localization for APOF Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for APOF gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 1
mitochondrion 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for APOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 14718574
GO:0034362 low-density lipoprotein particle IEA --
GO:0034364 high-density lipoprotein particle IEA --
genes like me logo Genes that share ontologies with APOF: view

Pathways & Interactions for APOF Gene

genes like me logo Genes that share pathways with APOF: view

Gene Ontology (GO) - Biological Process for APOF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 8093033
GO:0006810 transport IEA --
GO:0006869 lipid transport TAS,IEA --
GO:0008202 steroid metabolic process IEA --
GO:0008203 cholesterol metabolic process IEA,TAS --
genes like me logo Genes that share ontologies with APOF: view

No data available for SIGNOR curated interactions for APOF Gene

Drugs & Compounds for APOF Gene

Products:

  1. Drug

(2) Drugs for APOF Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for APOF Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with APOF: view

Transcripts for APOF Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for APOF Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for APOF Gene

Apolipoprotein F:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for APOF Gene

No ASD Table

Relevant External Links for APOF Gene

GeneLoc Exon Structure for
APOF
ECgene alternative splicing isoforms for
APOF

Expression for APOF Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for APOF Gene

mRNA expression in normal human tissues for APOF Gene
mRNA expression by BioGPS for APOF GenemRNA expression by GTEx for APOF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for APOF Gene

This gene is overexpressed in Liver (x52.6).

Protein differential expression in normal tissues from HIPED for APOF Gene

This gene is overexpressed in Serum (45.6) and Plasma (15.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for APOF Gene



NURSA nuclear receptor signaling pathways regulating expression of APOF Gene:

APOF

SOURCE GeneReport for Unigene cluster for APOF Gene:

Hs.534302

mRNA Expression by UniProt/SwissProt for APOF Gene:

Q13790-APOF_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma.

Evidence on tissue expression from TISSUES for APOF Gene

  • Liver(4.6)
  • Bone marrow(4)
genes like me logo Genes that share expression patterns with APOF: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for APOF Gene

Orthologs for APOF Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia APOF 35 34
  • 99.18 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia APOF 35 34
  • 78.86 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia APOF 35 34
  • 77.96 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Apof 34
  • 75.19 (n)
mouse
(Mus musculus)
 Mammalia Apof 35 16 34
  • 73.27 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia APOF 35
  • 33 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii apof 35
  • 19 (a)
 OneToOne
Species where no ortholog for APOF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APOF Gene

ENSEMBL:
Gene Tree for APOF (if available)
TreeFam:
Gene Tree for APOF (if available)

Paralogs for APOF Gene

Pseudogenes.org Pseudogenes for APOF Gene

genes like me logo Genes that share paralogs with APOF: view

No data available for Paralogs for APOF Gene

Variants for APOF Gene

Sequence variations from dbSNP and Humsavar for APOF Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000164732 -- 56,362,395(+) CTCGA(A/G)GGATC intron-variant
rs1001228611 -- 56,362,101(+) GTGGC(A/G)TCCAC upstream-variant-2KB, reference, synonymous-codon
rs1001243556 -- 56,364,673(+) GAATC(A/T)CAAGG upstream-variant-2KB
rs1001608340 -- 56,361,604(+) TAGCA(C/T)AATAC upstream-variant-2KB, reference, missense
rs1001619806 -- 56,361,975(+) ATGTG(A/G)CTGAA upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for APOF Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV gain+loss 15286789

Variation tolerance for APOF Gene

Residual Variation Intolerance Score: 73.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.53; 72.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for APOF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
APOF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOF Gene

Disorders for APOF Gene

Relevant External Links for APOF

Genetic Association Database (GAD)
APOF
Human Genome Epidemiology (HuGE) Navigator
APOF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APOF

No disorders were found for APOF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APOF Gene

Publications for APOF Gene

  1. Purification and molecular cloning of human apolipoprotein F. (PMID: 8093033) Day J.R. … Wolfbauer G. (Biochem. Biophys. Res. Commun. 1994) 2 3 4 22 64
  2. Molecular cloning and expression of lipid transfer inhibitor protein reveals its identity with apolipoprotein F. (PMID: 9880564) Wang X. … Morton R.E. (J. Biol. Chem. 1999) 3 4 22 64
  3. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) RuaA+o G. … Wu A.H. (Pharmacogenomics 2010) 3 46 64
  4. Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease. (PMID: 20855565) Peloso G.M. … Brousseau M.E. (J. Lipid Res. 2010) 3 46 64
  5. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger T.L. … Thio C.L. (J. Infect. Dis. 2010) 3 46 64

Products for APOF Gene

  • Cloud-Clone Corp. Antibodies for APOF
  • Cloud-Clone Corp. Proteins for APOF
  • Cloud-Clone Corp Assay Kits for APOF

Sources for APOF Gene

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