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Aliases for APOE Gene

Aliases for APOE Gene

  • Apolipoprotein E 2 3 5
  • APO-E 3 4
  • Alzheimer Disease 2 (APOE*E4-Associated, Late Onset) 2
  • Apolipoprotein E3 3
  • LDLCQ5 3
  • ApoE4 3
  • LPG 3
  • AD2 3

External Ids for APOE Gene

Previous HGNC Symbols for APOE Gene

  • AD2

Previous GeneCards Identifiers for APOE Gene

  • GC19P046053
  • GC19P045799
  • GC19P050085
  • GC19P050100
  • GC19P045408
  • GC19P041839

Summaries for APOE Gene

Entrez Gene Summary for APOE Gene

  • The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]

GeneCards Summary for APOE Gene

APOE (Apolipoprotein E) is a Protein Coding gene. Diseases associated with APOE include Lipoprotein Glomerulopathy and Sea-Blue Histiocyte Disease. Among its related pathways are Transcription_Role of VDR in regulation of genes involved in osteoporosis and Metabolism of fat-soluble vitamins. GO annotations related to this gene include protein homodimerization activity and receptor binding.

UniProtKB/Swiss-Prot for APOE Gene

  • Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.

Gene Wiki entry for APOE Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOE Gene

Genomics for APOE Gene

Regulatory Elements for APOE Gene

Enhancers for APOE Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G044721 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.5 -181.5 -181518 4.9 ARID4B SIN3A DMAP1 ZNF48 YY1 GATA2 ZNF143 ZNF207 FOS ZNF263 ENSG00000266903 APOE RELB APOC2 BCL3 CLASRP IGSF23 APOC4 ENSG00000252200 GC19M044726
GH19G044951 1.4 FANTOM5 Ensembl ENCODE 13.3 +45.9 45949 1.1 ZSCAN4 ARID4B RAD21 ZNF335 ZNF121 GATA2 SCRT2 ZNF143 SMARCA5 ZNF654 APOC2 APOE MARK4 ENSG00000267114
GH19G044856 1.5 Ensembl ENCODE dbSUPER 12.3 -48.0 -47977 3.5 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 TCF12 ZNF121 GATA2 NECTIN2 APOE ENSG00000266903 PIR35850 TOMM40
GH19G044868 1.4 Ensembl ENCODE dbSUPER 12 -36.1 -36100 3.1 FOXA2 MLX ARID4B ZNF48 ZNF121 FOS MCM3 SP5 MIER2 ZNF623 NECTIN2 TOMM40 APOE ZNF225 PIR35850
GH19G044909 1.4 Ensembl ENCODE 11.9 +6.9 6940 6.3 HDGF MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 FOS APOE RELB NECTIN2 BCAM GC19M044904 APOC1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around APOE on UCSC Golden Path with GeneCards custom track

Promoters for APOE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110117 451 1201 HDGF PKNOX1 AGO1 ARID4B DMAP1 ZNF48 ETS1 GLIS2 PAF1 SP3

Genomic Location for APOE Gene

Chromosome:
19
Start:
44,905,749 bp from pter
End:
44,909,395 bp from pter
Size:
3,647 bases
Orientation:
Plus strand

Genomic View for APOE Gene

Genes around APOE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOE Gene

Proteins for APOE Gene

  • Protein details for APOE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02649-APOE_HUMAN
    Recommended name:
    Apolipoprotein E
    Protein Accession:
    P02649
    Secondary Accessions:
    • B2RC15
    • C0JYY5
    • Q9P2S4

    Protein attributes for APOE Gene

    Size:
    317 amino acids
    Molecular mass:
    36154 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for APOE Gene

neXtProt entry for APOE Gene

Post-translational modifications for APOE Gene

  • Glycated in plasma VLDL of normal subjects, and of hyperglycemic diabetic patients at a higher level (2-3 fold).
  • Phosphorylated by FAM20C in the extracellular medium.
  • Synthesized with the sialic acid attached by O-glycosidic linkage and is subsequently desialylated in plasma. O-glycosylated with core 1 or possibly core 8 glycans. Thr-307 and Ser-314 are minor glycosylation sites compared to Ser-308.
  • Glycosylation at Thr26, Thr36, posLast=9393, Thr212, Thr307, posLast=308308, and posLast=314314
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for APOE (Apolipoprotein E3/ApoE3)
  • R&D Systems Antibodies for APOE (Apolipoprotein E/ApoE)
  • Cell Signaling Technology (CST) Antibodies for APOE (APOE)
  • Cell Signaling Technology (CST) Antibodies for APOE (APOE iso4)

Assay Products

No data available for DME Specific Peptides for APOE Gene

Domains & Families for APOE Gene

Gene Families for APOE Gene

Protein Domains for APOE Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for APOE Gene

Graphical View of Domain Structure for InterPro Entry

P02649

UniProtKB/Swiss-Prot:

APOE_HUMAN :
  • Belongs to the apolipoprotein A1/A4/E family.
Family:
  • Belongs to the apolipoprotein A1/A4/E family.
genes like me logo Genes that share domains with APOE: view

Function for APOE Gene

Molecular function for APOE Gene

GENATLAS Biochemistry:
apolipoprotein E,component of VLDL and ApoE receptors,putative susceptibility factor (epsilon 4 allele) for agressive multiple sclerosis and for early-onset coronary heart disease
UniProtKB/Swiss-Prot Function:
Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.

Gene Ontology (GO) - Molecular Function for APOE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 beta-amyloid binding IPI 9003062
GO:0005198 structural molecule activity TAS 22138302
GO:0005319 lipid transporter activity IDA 17305370
GO:0005515 protein binding IPI 7972031
GO:0005543 phospholipid binding IDA 4066713
genes like me logo Genes that share ontologies with APOE: view
genes like me logo Genes that share phenotypes with APOE: view

Human Phenotype Ontology for APOE Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for APOE Gene

MGI Knock Outs for APOE:

Animal Model Products

miRNA for APOE Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for APOE

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for APOE Gene

Localization for APOE Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOE Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for APOE gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
endoplasmic reticulum 5
golgi apparatus 5
endosome 5
cytoskeleton 2
mitochondrion 2
peroxisome 2
cytosol 2
lysosome 2

Gene Ontology (GO) - Cellular Components for APOE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IDA 16502470
GO:0005623 cell IEA --
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm TAS 9622609
genes like me logo Genes that share ontologies with APOE: view

Pathways & Interactions for APOE Gene

genes like me logo Genes that share pathways with APOE: view

SIGNOR curated interactions for APOE Gene

Activates:

Gene Ontology (GO) - Biological Process for APOE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000302 response to reactive oxygen species NAS 11743999
GO:0001523 retinoid metabolic process TAS --
GO:0001937 negative regulation of endothelial cell proliferation IDA 9685360
GO:0002021 response to dietary excess IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with APOE: view

Drugs & Compounds for APOE Gene

(80) Drugs for APOE Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
atorvastatin Approved Pharma Competitive, Inhibitor 0
Donepezil Approved Pharma 286
Fluvastatin Approved Pharma Competitive, Inhibitor HMGCR inhibitor 58
Galantamine Approved Pharma 106
Nicotine Approved Pharma Antagonist 1103

(55) Additional Compounds for APOE Gene - From: Novoseek and HMDB