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APOD Gene

protein-coding   GIFtS: 59
GCID: GC03M195295

Apolipoprotein D

  See APOD-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Apolipoprotein D1 2
apo-D2
Apo-D3
ApoD3

External Ids:    HGNC: 6121   Entrez Gene: 3472   Ensembl: ENSG000001890587   OMIM: 1077405   UniProtKB: P050903   

Export aliases for APOD gene to outside databases

Previous GC identifers: GC03P194400 GC03M198737 GC03M9E0110 GC00M9Z0110 GC03M9G0110 GC03M196776 GC03M192666


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for APOD Gene:
This gene encodes a component of high density lipoprotein that has no marked similarity to other apolipoprotein
sequences. It has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2
microglobulin protein superfamily of carrier proteins, also known as lipocalins. This glycoprotein is closely
associated with the enzyme lecithin:cholesterol acyltransferase - an enzyme involved in lipoprotein metabolism.
(provided by RefSeq, Aug 2008)

GeneCards Summary for APOD Gene:
APOD (apolipoprotein D) is a protein-coding gene. Diseases associated with APOD include anaplastic astrocytoma, and breast cyst. GO annotations related to this gene include cholesterol binding and lipid transporter activity.

UniProtKB/Swiss-Prot: APOD_HUMAN, P05090
Function: APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably
involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number
of different contexts

Gene Wiki entry for APOD (Apolipoprotein D) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the APOD gene promoter:
         c-Rel   STAT1   Pax-2b   FOXO4   Pax-2   Pax-2a   ITF-2   Tal-1beta   Hlf   ATF   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for APOD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat APOD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

APOD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOD gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M195295:  view genomic region     (about GC identifiers)

Start:
195,295,573 bp from pter      End:
195,311,076 bp from pter
Size:
15,504 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: APOD_HUMAN, P05090 (See protein sequence)
Recommended Name: Apolipoprotein D precursor  
Size: 189 amino acids; 21276 Da
Subunit: Homodimer. In plasma, also exists as a disulfide-linked heterodimer with APOA2
Miscellaneous: APOD is primarily localized in HDL (60-65%), with most of the remainder in VHDL and only trace
amounts in VLDL and LDL
3 PDB 3D structures from and Proteopedia for APOD:
2APD (3D)        2HZQ (3D)        2HZR (3D)    
Secondary accessions: B2R579 D3DNW6 Q6IBG6

Explore the universe of human proteins at neXtProt for APOD: NX_P05090

Explore proteomics data for APOD at MOPED

Post-translational modifications: 

  • N-glycosylatd. N-glycan heterogeneity at Asn-65: Hex5HexNAc4 (major) and Hex6HexNAc5 (minor); at Asn-98:
    Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major), dHex1Hex6HexNAc5 (minor) and dHex1Hex7HexNAc6 (minor)1
  • Glycosylation2 at Asn65, Asn98

  • See APOD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001638.1  
    ENSEMBL proteins: 
     ENSP00000345179   ENSP00000391597   ENSP00000415235   ENSP00000393076  

    APOD Human Recombinant Protein Products:

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    Novus Biologicals APOD Proteins
    Novus Biologicals APOD Lysate
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    ProSpec Recombinant Protein for APOD
    Cloud-Clone Corp. Proteins for APOD

     
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    APOD Assay Products:

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    Search eBioscience for ELISAs for APOD 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    LCN: Lipocalins
    APOLIPO: Apolipoproteins

    Selected InterPro protein domains (see all 8):
     IPR022271 Lipocalin_ApoD
     IPR002969 ApolipopD
     IPR026222 ApoD_vertbrte
     IPR012674 Calycin
     IPR011038 Calycin-like

    Graphical View of Domain Structure for InterPro Entry P05090

    ProtoNet protein and cluster: P05090

    2 Blocks protein domains:
    IPB002345 Lipocalin signature
    IPB002969 Apolipoprotein D signature


    UniProtKB/Swiss-Prot: APOD_HUMAN, P05090
    Similarity: Belongs to the calycin superfamily. Lipocalin family


    Find genes that share domains with APOD           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APOD_HUMAN, P05090
    Function: APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably
    involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number
    of different contexts

         Genatlas biochemistry entry for APOD:
    apolipoprotein D (lipocalin family,Kernel group),widely distributed,occuring in macromolecular
    complexes,predominantly with APOA2 in HDL and APOB-100 in LDL and VLDL,identical to gross-cystic disease fluid
    progesterone/pregnelonone binding protein representing overhalf of the protein component of breast cyst fluid

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005319lipid transporter activity NAS3453108
    GO:0005515protein binding IPI7918467
    GO:0008289lipid binding ----
    GO:0015485cholesterol binding IDA9278274
         
    Find genes that share ontologies with APOD           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for APOD:
     Increased cell death in breast 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Apod):
     behavior/neurological  cardiovascular system  hearing/vestibular/ear  homeostasis/metabolism  mortality/aging 
     nervous system 

    Find genes that share phenotypes with APOD           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for APOD: Apodtm1Bres Apodtm1Dsan

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for APOD
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for APOD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for APOD
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for APOD

    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat APOD

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: APOD (NM_001647)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for APOD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOD

    Cell Line
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    ESI BIO PureStem Progenitor for APOD: 
    PureStem MEL2, NCr-fac Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOD


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    APOD_HUMAN, P05090: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol4
    endoplasmic reticulum4
    cytoskeleton1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005615extracellular space IDA--
    GO:0005622intracellular ----
    GO:0005783endoplasmic reticulum ISS--
    GO:0022626cytosolic ribosome ISS--

    Find genes that share ontologies with APOD           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for APOD About    
    See pathways by source

    SuperPathContained pathways About
    1Cholesterol and Sphingolipids transport Recycling to plasma membrane in lung normal and CF
    Cholesterol and Sphingolipids transport Recycling to plasma membrane in lung normal and CF

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for APOD
        Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF)


        Pathway & Disease-focused RT2 Profiler PCR Array including APOD: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for APOD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for APOD (P050902, 3 ENSP000003451794) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYZAPP0CAP12, 3MINT-65205 I2D: score=4 
    STK24Q9Y6E03, ENSP000003657304I2D: score=2 STRING: ENSP00000365730
    APOA2P026523, ENSP000003569694I2D: score=2 STRING: ENSP00000356969
    LEPRP483573, ENSP000003303934I2D: score=3 STRING: ENSP00000330393
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000302response to reactive oxygen species IDA18419796
    GO:0001525angiogenesis NAS--
    GO:0006006glucose metabolic process IDA19176353
    GO:0006629lipid metabolic process IDA19176353
    GO:0006869lipid transport NAS3453108

    Find genes that share ontologies with APOD           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for APOD

    Selected Novoseek inferred chemical compound relationships for APOD gene (see all 22)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arachidonic acid 52.8 39 15560970 (7), 14623496 (4), 7789516 (3), 19429117 (2) (see all 13)
    progesterone 48.1 24 1868457 (1), 11058760 (1), 12021176 (1), 16850244 (1) (see all 16)
    lipid 45.5 42 19519777 (4), 19723339 (3), 19176353 (2), 11274430 (1) (see all 21)
    dihydrotestosterone 42.6 4 7929425 (1), 19330472 (1)
    cholesterol 38.1 40 1582022 (3), 9422368 (3), 19429117 (2), 7789516 (2) (see all 13)
    clozapine 32 17 12363390 (3), 17011169 (3), 11274430 (1), 12911617 (1) (see all 5)
    cyanogen bromide 27.7 3 7918467 (1), 9659402 (1)
    steroid 26 14 1868457 (1), 7927949 (1), 7526888 (1), 11709627 (1) (see all 9)
    vitamin a 21.6 5 16461020 (2), 9278274 (1), 19390610 (1)
    estrogen 12.1 10 7929425 (1), 16850244 (1), 19107621 (1), 17589901 (1) (see all 6)



    Find genes that share compounds with APOD           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for APOD gene: 
    NM_001647.3  

    Unigene Cluster for APOD:

    Apolipoprotein D
    Hs.522555  [show with all ESTs]
    Unigene Representative Sequence: BF790155
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343267(uc003fur.2) ENST00000458447 ENST00000421243 ENST00000453131
    ENST00000463719(uc011bsx.1)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat APOD
      QuantiFast Probe-based Assays in human, mouse, rat APOD

    Additional mRNA sequence: 

    AK294523.1 AK312090.1 BC007402.2 BT019860.1 BT019861.1 CR456838.1 CR541773.1 J02611.1 
    S80440.1 

    17 DOTS entries:

    DT.450718  DT.97761904  DT.99954896  DT.91774835  DT.91774833  DT.91805361  DT.100827291  DT.120864970 
    DT.95166229  DT.95166241  DT.99943362  DT.100827294  DT.120864927  DT.120864975  DT.91774837  DT.95166228 
    DT.95166230 

    Selected AceView cDNA sequences (see all 525):

    AA365126 AI497793 AA136690 BU195270 BQ684313 H44604 AA033790 BQ717370 
    CA391995 S80440 BQ938935 BU731517 AA363956 CD679198 AA425640 BQ434159 
    BQ425747 CD677880 CD678344 BQ955693 BM694427 BU155874 BM688920 BF724142 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    APOD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTACCCTG
    APOD Expression
    About this image


    APOD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Fibroblasts
             Human Dermal Fibroblasts-adult (HDF-a)   
     
     Dermis (Integumentary System)    fully expand to see all 5 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
             Human Dermal Fibroblasts-adult (HDF-a)   
     
     Bone (Muscoskeletal System)    fully expand to see all 9 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 8 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Adult Endothelial Cells Blood Brain Barrier
             Cerebellum
    APOD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    APOD Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522555

    UniProtKB/Swiss-Prot: APOD_HUMAN, P05090
    Tissue specificity: Expressed in liver, intestine, pancreas, kidney, placenta, adrenal, spleen, fetal brain tissue
    and tears

        Pathway & Disease-focused RT2 Profiler PCR Array including APOD: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat APOD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for APOD gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Apod1 , 5 apolipoprotein D1, 5 78.74(n)1
    73.56(a)1
      16 (21.41 cM)5
    118151  NM_007470.31  NP_031496.21 
     312961925 
    chicken
    (Gallus gallus)
    Aves APOD1 apolipoprotein D 64.34(n)
    59.88(a)
      424893  NM_001011692.1  NP_001011692.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1233391 zgc:123339 58.04(n)
    51.18(a)
      567972  NM_001037695.1  NP_001032784.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta NLaz1 Neural Lazarillo 49.9(n)
    40.94(a)
      33324  NM_001272938.1  NP_001259867.1 


    ENSEMBL Gene Tree for APOD (if available)
    TreeFam Gene Tree for APOD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for APOD gene
    Selected SIMAP similar genes for APOD using alignment to 4 protein entries:     APOD_HUMAN (see all proteins) (see all similar genes):
    AURA2    EDRF1    ZNF20    ZNF74    DCTN5    ZNF546
    ZNF585B    TMEM44    NSRP1    RUFY1    CFLAR    CTSS
    ERBB2    ZNF547    UTY    PKN1    SHANK2    ZNF737

    Find genes that share paralogs with APOD           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for APOD (see all 495)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1163654241,2
    F--195295094(+) ATCTGG/AATTCA 1 -- int11Minor allele frequency- A:0.04WA 118
    rs782947521,2
    C,F--195295114(+) GAATAC/TGCCTT 1 -- int11Minor allele frequency- T:0.17WA 118
    rs757887051,2
    C,F--195295138(+) CCCCAC/TTCCAG 1 -- int12Minor allele frequency- T:0.20WA EA 238
    rs46776891,2
    C,F,A--195295166(+) TTAAAC/TGAGGA 1 -- int114Minor allele frequency- T:0.05NA WA CSA EA 514
    rs1809680961,2
    --195295206(+) ACTGCC/TTAAGG 1 -- int10--------
    rs2019969651,2
    --195295212(+) AAGGA-/TTTTTT 1 -- int10--------
    rs1430521221,2
    --195295243(+) AGGCAA/GGGTCT 1 -- int10--------
    rs1860617031,2
    --195295278(+) CAGTGG/TTGCCA 1 -- int10--------
    rs780015161,2
    C,F--195295296(+) TCACTG/ATACCC 1 -- int13Minor allele frequency- A:0.06WA CSA 122
    rs1386026101,2
    C--195295357(+) AGCACA/GGGTGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for APOD (195295573 - 195311076 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for APOD:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv878146CNV Loss21882294
    nsv878138CNV Gain21882294
    nsv428430CNV Gain+Loss18775914
    dgv1549e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): APOD
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing APOD
    DNA2.0 Custom Variant and Variant Library Synthesis for APOD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 107740    OMIM disorders: --

    10 diseases for APOD:    
    About MalaCards
    anaplastic astrocytoma    breast cyst    gynecomastia    ganglioglioma
    neurofibroma    male breast cancer    pilocytic astrocytoma    pick's disease
    astrocytoma    schizophrenia


    Find genes that share disorders with APOD           About GenesLikeMe

    Selected Novoseek inferred disease relationships for APOD gene (see all 38)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast male carcinoma 57.1 2 12678518 (1), 10504376 (1)
    pilocytic astrocytoma 53.8 7 11895042 (4), 16055749 (2)
    breast cysts 49.5 2 9075775 (2)
    niemann-picks disease type c 44.7 2 12646752 (1), 9422368 (1)
    breast cancer 40.5 52 8943263 (5), 17452772 (4), 19107621 (3), 12678530 (3) (see all 20)
    breast diseases 39.9 1 9293309 (1)
    neuropathology 39.3 12 9751198 (2), 11739619 (1), 14500696 (1), 18842892 (1) (see all 6)
    breast carcinoma 38.6 11 9307298 (2), 7929425 (1), 18505051 (1), 8943263 (1) (see all 7)
    ganglioglioma 37.6 2 16055749 (2)
    malignant peripheral nerve sheath tumors 36.4 3 15252314 (1), 16153462 (1)

    Genetic Association Database (GAD): APOD
    Human Genome Epidemiology (HuGE) Navigator: APOD (16 documents)

    Export disorders for APOD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for APOD gene, integrated from 10 sources (see all 204):
    (articles sorted by number of sources associating them with APOD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human apolipoprotein D gene: gene sequence, chromosome localization, and homology to the alpha 2u-globulin superfamily. (PubMed id 2439269)1, 2, 3 Drayna D.T....Lawn R.M. (DNA 1987)
    2. Cloning and expression of human apolipoprotein D cDNA. (PubMed id 3453108)1, 2, 3 Drayna D.T.... Lawn R.M. (J. Biol. Chem. 1986)
    3. Apolipoprotein D is associated with long-term outcome in patients with schizophrenia. (PubMed id 16402085)1, 4, 9 Hansen T....Werge T. (Pharmacogenomics J. 2006)
    4. Apolipoprotein D levels are elevated in prefrontal cortex of subjects with Alzheimer's disease: no relation to apolipoprotein E expression or genotype. (PubMed id 12873803)1, 4, 9 Thomas E.A....Martins R.N. (Biol. Psychiatry 2003)
    5. The human lacrimal gland synthesizes apolipoprotein D mRNA in addition to tear prealbumin mRNA, both species encoding members of the lipocalin superfamily. (PubMed id 8549691)1, 2, 9 Holzfeind P.... Redl B. (Exp. Eye Res. 1995)
    6. Structure of human apolipoprotein D: locations of the intermolecular and intramolecular disulfide links. (PubMed id 7918467)1, 2, 9 Yang C.-Y.... Pownall H.J. (Biochemistry 1994)
    7. Genetic variation in apolipoprotein D and Alzheimer's disease. (PubMed id 15316799)1, 4, 9 Helisalmi S....Soininen H. (J. Neurol. 2004)
    8. Genetic variation in apolipoprotein D affects the risk of Alzheimer disease in African-Americans. (PubMed id 12497622)1, 4, 9 Desai P.P....Kamboh M.I. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003)
    9. Association between polymorphisms in the apolipoprotein D gene and sporadic Alzheimer's disease. (PubMed id 18671953)1, 4, 9 Chen Y....Jia J. (Brain Res. 2008)
    10. Analysis of the association between Apolipoprotein D and schizophrenia. (PubMed id 16966838)1, 4, 9 Zhang X....He L. (Neuropsychobiology 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 347 HGNC: 612 AceView: APOD Ensembl:ENSG00000189058 euGenes: HUgn347
    ECgene: APOD H-InvDB: APOD

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for APOD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for APOD gene:
    Search GeneIP for patents involving APOD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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