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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

APOD Gene

protein-coding   GIFtS: 60
GCID: GC03M195295

apolipoprotein D
 Explore 48 diseases affiliated with
APOD via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for APOD    

Aliases
for APOD gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Apolipoprotein D1 2
Apo-D3
Apo-D3
ApoD3

External Ids:    HGNC: 6121   Entrez Gene: 3472   Ensembl: ENSG000001890587   OMIM: 1077405   UniProtKB: P050903   

Export aliases for APOD gene to outside databases

Previous GC identifers: GC03P194400 GC03M198737 GC03M9E0110 GC00M9Z0110 GC03M9G0110 GC03M196776 GC03M192666


Summaries
for APOD gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for APOD:
This gene encodes a component of high density lipoprotein that has no marked similarity to other apolipoprotein
sequences. It has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2
microglobulin protein superfamily of carrier proteins, also known as lipocalins. This glycoprotein is closely
associated with the enzyme lecithin:cholesterol acyltransferase - an enzyme involved in lipoprotein metabolism.
(provided by RefSeq, Aug 2008)

UniProtKB/Swiss-Prot: APOD_HUMAN, P05090
Function: APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved
in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different
contexts

Gene Wiki entry for APOD (Apolipoprotein D)


Genomic Views
for APOD gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_029928.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the APOD gene promoter:
         c-Rel   STAT1   Pax-2b   FOXO4   Pax-2   Pax-2a   ITF-2   Tal-1beta   Hlf   ATF   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for APOD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.2-qter   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q26.2-qter

APOD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOD gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M195295:  view genomic region     (about GC identifiers)

Start:
 195,295,573 bp from pter      End:
 195,311,076 bp from pter
Size:
 15,504 bases      Orientation:
 minus strand

Proteins
for APOD gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: APOD_HUMAN, P05090 (See protein sequence)
Recommended Name: Apolipoprotein D precursor  
Size: 189 amino acids; 21276 Da
Subunit: Homodimer. In plasma, also exists as a disulfide-linked heterodimer with APOA2
Subcellular location: Secreted
Miscellaneous: APOD is primarily localized in HDL (60-65%), with most of the remainder in VHDL and only trace amounts
in VLDL and LDL
3 PDB 3D structures from and Proteopedia for APOD:
2APD (3D)        2HZQ (3D)        2HZR (3D)    
Secondary accessions: B2R579 D3DNW6 Q6IBG6

Explore the universe of human proteins at neXtProt for APOD: NX_P05090

Post-translational modifications:

  • N-glycosylatd. N-glycan heterogeneity at Asn-65: Hex5HexNAc4 (major) and Hex6HexNAc5 (minor); at Asn-98: Hex5HexNAc4
    • (minor), dHex1Hex5HexNAc4 (major), dHex1Hex6HexNAc5 (minor) and dHex1Hex7HexNAc6 (minor)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P05090

    • APOD Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001638.1  
    ENSEMBL proteins: 
     ENSP00000345179   ENSP00000391597   ENSP00000415235   ENSP00000393076  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: APOD
    OriGene Protein Over-expression Lysate: APOD
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    Novus Biologicals APOD Proteins
    Novus Biologicals APOD Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for APOD
    Uscn Proteins for APOD

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005615extracellular space IDA--
    GO:0005622intracellular ----
    GO:0005783endoplasmic reticulum ISS--
    GO:0022626cytosolic ribosome ISS--


    APOD for ontologies           About GeneDecksing



    APOD Antibody Products: 
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    Uscn Antibodies for APOD
    ThermoFisher Antibodies for APOD

    Assay Products for APOD: 
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    Uscn ELISAs and CLIAs for APOD

    Protein Domains /
    Families
    for APOD gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    APOD for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR022271 Lipocalin_ApoD
     IPR022272 Lipocalin_CS
     IPR002969 ApolipopD
     IPR000566 Lipocln_cytosolic_FA-bd_dom
     IPR026222 ApoD_vertbrte

    Graphical View of Domain Structure for InterPro Entry P05090

    ProtoNet protein and cluster: P05090

    2 Blocks protein families:
    IPB002345 Lipocalin signature
    IPB002969 Apolipoprotein D signature


    UniProtKB/Swiss-Prot: APOD_HUMAN, P05090
    Similarity: Belongs to the calycin superfamily. Lipocalin family


    Function
    for APOD gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: APOD_HUMAN, P05090
    Function: APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved
    in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different
    contexts

         Genatlas biochemistry entry for APOD:
    apolipoprotein D (lipocalin family,Kernel group),widely distributed,occuring in macromolecular complexes,predominantly
    with APOA2 in HDL and APOB-100 in LDL and VLDL,identical to gross-cystic disease fluid progesterone/pregnelonone
    binding protein representing overhalf of the protein component of breast cyst fluid

    miRNA
    Products:            		 OriGene 3'-UTR Clone: APOD
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APOD
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate APOD
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APOD (see all 7)
    OriGene shRNA RFP: APOD
    OriGene siRNA: APOD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APOD

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for APOD

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APOD (see all 3)
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    GenScript: all cDNA clones in your preferred vector: APOD (NM_001647)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for APOD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOD 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for APOD
    LifeMap BioReagents: cell line associated with APOD: PureStem MEL2, NCr-fac Progenitor

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOD

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005319lipid transporter activity NAS3453108
    GO:0005515protein binding IPI7918467
    GO:0008289lipid binding ----
    GO:0015485cholesterol binding IDA9278274


    APOD for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for APOD:
     Increased cell death in breast 

    Animal Models:
         Mouse knock-outs for APOD: Apodtm1Hhmd Apodtm1Dsan
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Apod):
     behavior/neurological  hearing/vestibular/ear  homeostasis/metabolism  mortality/aging  nervous system 

    APOD for phenotypes           About GeneDecksing


    Pathways & Interactions
    for APOD gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF)
    		Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF)1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for APOD
        Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF)


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for APOD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/47 Interacting proteins for APOD (P050902, 3 ENSP000003451794) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GCOM1P0CAP12, 3MINT-65205 I2D: score=4 
    MYZAPP0CAP12, 3MINT-65205 I2D: score=4 
    STK24Q9Y6E03, ENSP000003657304I2D: score=2 STRING: ENSP00000365730
    APOA2P026523, ENSP000003569694I2D: score=2 STRING: ENSP00000356969
    LEPRP483573, ENSP000003303934I2D: score=3 STRING: ENSP00000330393
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000302response to reactive oxygen species IDA18419796
    GO:0001525angiogenesis NAS--
    GO:0006006glucose metabolic process IDA19176353
    GO:0006629lipid metabolic process IDA19176353
    GO:0006869lipid transport NAS3453108


    APOD for ontologies           About GeneDecksing



    Drugs & Compounds
    for APOD gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    APOD for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for APOD
    10/22 Novoseek chemical compound relationships for APOD gene (see all 22)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arachidonic acid 52.8 39 15560970 (7), 14623496 (4), 7789516 (3), 19429117 (2) (see all 13)
    progesterone 48.1 24 1868457 (1), 11058760 (1), 12021176 (1), 16850244 (1) (see all 16)
    lipid 45.5 42 19519777 (4), 19723339 (3), 19176353 (2), 11274430 (1) (see all 21)
    dihydrotestosterone 42.6 4 7929425 (1), 19330472 (1)
    cholesterol 38.1 40 1582022 (3), 9422368 (3), 19429117 (2), 7789516 (2) (see all 13)
    clozapine 32 17 12363390 (3), 17011169 (3), 11274430 (1), 12911617 (1) (see all 5)
    cyanogen bromide 27.7 3 7918467 (1), 9659402 (1)
    steroid 26 14 1868457 (1), 7927949 (1), 7526888 (1), 11709627 (1) (see all 9)
    vitamin a 21.6 5 16461020 (2), 9278274 (1), 19390610 (1)
    estrogen 12.1 10 7929425 (1), 16850244 (1), 19107621 (1), 17589901 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about APOD 

    Transcripts
    for APOD gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for APOD gene: 
    NM_001647.3  

    Unigene Cluster for APOD:

    Apolipoprotein D
    Hs.522555  [show with all ESTs]
    Unigene Representative Sequence: BF790155
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343267(uc003fur.2) ENST00000458447 ENST00000421243 ENST00000453131
    ENST00000463719(uc011bsx.1)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APOD
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APOD (see all 7)
    OriGene shRNA RFP: APOD
    OriGene siRNA: APOD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APOD
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APOD (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APOD
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: APOD (NM_001647)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for APOD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOD 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APOD

    Additional cDNA sequence: 

    AK294523.1 AK312090.1 BC007402.2 BT019860.1 BT019861.1 CR456838.1 CR541773.1 J02611.1 
    S80440.1 

    17 DOTS entries:

    DT.450718  DT.97761904  DT.99954896  DT.91774835  DT.91774833  DT.91805361  DT.100827291  DT.120864970 
    DT.95166229  DT.95166241  DT.99943362  DT.100827294  DT.120864927  DT.120864975  DT.91774837  DT.95166228 
    DT.95166230 

    24/525 AceView cDNA sequences (see all 525):

    BQ270392 BI755710 AA365128 AA364921 S80440 AA033790 BM694427 BU731517 
    AA365126 BI819272 BU160982 BQ721355 AA411564 AW389748 BQ678512 BF724142 
    H44604 CA391787 BQ719426 BI755755 AI379448 CA391995 BM685383 BM687661 

    GeneLoc Exon Structure


    Expression
    for APOD gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    APOD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCTACCCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    APOD expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierAdult Endothelial CellsBlood Brain Barrier, Endothelium
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    Skeletal MuscleExtraocular MusclesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/12 LifeMap Cells (see all 12) 
    NameCategory
    PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    HyStem+BMP4-induced SM30 cells (HyStem+BMP4 inductio...)Adipose, Bone, Cartilage
    HyStem+TGF?3+GDF5-induced SM30 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage
    HyStem+TGF?3+GDF5-induced MEL2 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage
    HyStem+BMP4-induced MEL2 cells (HyStem+BMP4 inductio...)Bone
    HyStem+BMP4-induced 7SMOO32 cells (HyStem+BMP4 inductio...)Adipose
    HyStem+TGF?3+GDF5-induced 7SMOO32 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage
    HyStem+BMP4-induced 4D20.8 cells (Chondrogenic inducti...)Bone, Cartilage

    See APOD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for APOD

    SOURCE GeneReport for Unigene cluster: Hs.522555

    UniProtKB/Swiss-Prot: APOD_HUMAN, P05090
    Tissue specificity: Expressed in liver, intestine, pancreas, kidney, placenta, adrenal, spleen, fetal brain tissue and
    tears

        SABiosciences Expression via Pathway-Focused PCR Array including APOD: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOD

    Orthologs
    for APOD gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for APOD gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Apod1 , 5 apolipoprotein D1, 5 78.49(n)1
    73.12(a)1    		   16 (21.41 cM)5
    118151  NM_007470.31  NP_031496.21 
     312961925 
    chicken
    (Gallus gallus)    		 Aves APOD1 apolipoprotein D 64.06(n)
    59.78(a)    		   424893  NM_001011692.1  NP_001011692.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1233391 zgc:123339 57.5(n)
    51.46(a)    		   567972  NM_001037695.1  NP_001032784.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta NLaz1 Neural Lazarillo 49.63(n)
    40.11(a)    		   33324  NM_175946.1  NP_787960.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATTIL6
    		 outer membrane lipoprotein Blc
    		 25(a)
    		 1 ↔ 1
    		 5(23500061-23501209)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 OsTIL-2 Temperature-induced lipocalin-2, expresse...
    OsTIL-1 Temperature-induced lipocalin-1, expresse...
    		 27(a)
    25(a)
    		 possible ortholog
    possible ortholog
    		 8(21404694-21406066)
    2(24146243-24147204)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria blc6
    		 outer membrane lipoprotein (lipocalin), cell divis...
    		 29(a)
    		 1 ↔ 1
    		 Chromosome(4375212-4375745)


    ENSEMBL Gene Tree for APOD (if available)
    TreeFam Gene Tree for APOD (if available) 

    Paralogs
    for APOD gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for APOD gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/425 NCBI SNPs in APOD are shown (see all 425)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1163654241,2
    		F,--195295094(+) ATCTGG/AATTCA 1 -- int11Minor allele frequency- A:0.04WA 118
    rs782947521,2
    		F,--195295114(+) GAATAC/TGCCTT 1 -- int11Minor allele frequency- T:0.17WA 118
    rs757887051,2
    		C,F,--195295138(+) CCCCAC/TTCCAG 1 -- int12Minor allele frequency- T:0.20WA EA 238
    rs46776891,2
    		C,F,A,--195295166(+) TTAAAC/TGAGGA 1 -- int114Minor allele frequency- T:0.05NA WA CSA EA 514
    rs1809680961,2
    		--195295206(+) ACTGCC/TTAAGG 1 -- int10--------
    rs2019969651,2
    		--195295212(+) AAGGA-/TTTTTT 1 -- int10--------
    rs1430521221,2
    		--195295243(+) AGGCAA/GGGTCT 1 -- int10--------
    rs1860617031,2
    		--195295278(+) CAGTGG/TTGCCA 1 -- int10--------
    rs780015161,2
    		C,F,--195295296(+) TCACTG/ATACCC 1 -- int13Minor allele frequency- A:0.06WA CSA 122
    rs1386026101,2
    		--195295357(+) AGCACA/GGGTGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for APOD (195295573 - 195311076 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for APOD
         2 CNVs: 32549 2491
    Human Gene Mutation Database (HGMD): APOD

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing APOD
    DNA2.0 Custom Variant and Variant Library Synthesis for APOD

    Disorders / Diseases
    for APOD gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    APOD for disorders           About GeneDecksing

    OMIM gene information: 107740    OMIM disorders: --

    20/48 diseases for APOD (see all 48):    About MalaCards
    retinol binding protein    niemann-pick disease    androgen insensitivity syndrome    dermatofibrosarcoma protuberans
    pilocytic astrocytoma    cholesterol    pick's disease    anaplastic astrocytoma
    gynecomastia    dermatofibrosarcoma    ganglioglioma    insulin resistance
    cutaneous malignant melanoma    neurofibroma    breast cyst    bipolar disorder
    coronary heart disease    astrocytoma    ductal carcinoma in situ    gestational diabetes

    10/38 Novoseek disease relationships for APOD gene (see all 38)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast male carcinoma 57.1 2 12678518 (1), 10504376 (1)
    pilocytic astrocytoma 53.8 7 11895042 (4), 16055749 (2)
    breast cysts 49.5 2 9075775 (2)
    niemann-picks disease type c 44.7 2 12646752 (1), 9422368 (1)
    breast cancer 40.5 52 8943263 (5), 17452772 (4), 19107621 (3), 12678530 (3) (see all 20)
    breast diseases 39.9 1 9293309 (1)
    neuropathology 39.3 12 9751198 (2), 11739619 (1), 14500696 (1), 18842892 (1) (see all 6)
    breast carcinoma 38.6 11 9307298 (2), 7929425 (1), 18505051 (1), 8943263 (1) (see all 7)
    ganglioglioma 37.6 2 16055749 (2)
    malignant peripheral nerve sheath tumors 36.4 3 15252314 (1), 16153462 (1)

    Genetic Association Database (GAD): APOD
    Human Genome Epidemiology (HuGE) Navigator: APOD (16 documents)

    Export disorders for APOD gene to outside databases

    Publications
    for APOD gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for APOD gene, integrated from 9 sources (see all 198):
    (articles sorted by number of sources associating them with APOD)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human apolipoprotein D gene: gene sequence, chromosome localization, and homology to the alpha 2u-globulin superfamily. (PubMed id 2439269)1, 2, 3 Drayna D.T....Lawn R.M. (1987)
    2. Cloning and expression of human apolipoprotein D cDNA. (PubMed id 3453108)1, 2, 3 Drayna D.T.... Lawn R.M. (1986)
    3. Apolipoprotein D levels are elevated in prefrontal cortex of subjects with Alzheimer's disease: no relation to apolipoprotein E expression or genotype. (PubMed id 12873803)1, 4, 9 Thomas E.A....Martins R.N. (2003)
    4. The human lacrimal gland synthesizes apolipoprotein D mRNA in addition to tear prealbumin mRNA, both species encoding members of the lipocalin superfamily. (PubMed id 8549691)1, 2, 9 Holzfeind P.... Redl B. (1995)
    5. Structure of human apolipoprotein D: locations of the intermolecular and intramolecular disulfide links. (PubMed id 7918467)1, 2, 9 Yang C.-Y.... Pownall H.J. (1994)
    6. Genetic variation in apolipoprotein D and Alzheimer's disease. (PubMed id 15316799)1, 4, 9 Helisalmi S....Soininen H. (2004)
    7. Genetic variation in apolipoprotein D affects the risk of Alzheimer disease in African-Americans. (PubMed id 12497622)1, 4, 9 Desai P.P....Kamboh M.I. (2003)
    8. Apolipoprotein D is the major protein component in cyst fluid from women with human breast gross cystic disease. (PubMed id 2244881)1, 2, 9 Balbin M.... Lopez-Otin C. (1990)
    9. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    10. Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PubMed id 14760718)1, 2 Bunkenborg J.... Wisniewski J.R. (2004)

    External Searches for APOD gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing APOD gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 347 HGNC: 612 AceView: APOD Ensembl:ENSG00000189058 euGenes: HUgn347
    ECgene: APOD H-InvDB: APOD

    Other Databases showing APOD gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing APOD gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for APOD Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for APOD gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for APOD gene:
    Search GeneIP for patents involving APOD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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