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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

APOD Gene

protein-coding   GIFtS: 60
GCID: GC03M195295

Apolipoprotein D

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Apolipoprotein D1 2
apo-D2
Apo-D3
ApoD3

External Ids:    HGNC: 6121   Entrez Gene: 3472   Ensembl: ENSG000001890587   OMIM: 1077405   UniProtKB: P050903   

Export aliases for APOD gene to outside databases

Previous GC identifers: GC03P194400 GC03M198737 GC03M9E0110 GC00M9Z0110 GC03M9G0110 GC03M196776 GC03M192666


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for APOD Gene:
This gene encodes a component of high density lipoprotein that has no marked similarity to other apolipoprotein
sequences. It has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2
microglobulin protein superfamily of carrier proteins, also known as lipocalins. This glycoprotein is closely
associated with the enzyme lecithin:cholesterol acyltransferase - an enzyme involved in lipoprotein metabolism.
(provided by RefSeq, Aug 2008)

GeneCards Summary for APOD Gene: 
APOD (apolipoprotein D) is a protein-coding gene. Diseases associated with APOD include anaplastic astrocytoma, and breast cyst. GO annotations related to this gene include cholesterol binding and lipid transporter activity.

UniProtKB/Swiss-Prot: APOD_HUMAN, P05090
Function: APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably
involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number
of different contexts

Gene Wiki entry for APOD (Apolipoprotein D) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_029928.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the APOD gene promoter:
         c-Rel   STAT1   Pax-2b   FOXO4   Pax-2   Pax-2a   ITF-2   Tal-1beta   Hlf   ATF   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for APOD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

APOD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOD gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M195295:  view genomic region     (about GC identifiers)

Start:
195,295,573 bp from pter      End:
195,311,076 bp from pter
Size:
15,504 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: APOD_HUMAN, P05090 (See protein sequence)
Recommended Name: Apolipoprotein D precursor  
Size: 189 amino acids; 21276 Da
Subunit: Homodimer. In plasma, also exists as a disulfide-linked heterodimer with APOA2
Subcellular location: Secreted
Miscellaneous: APOD is primarily localized in HDL (60-65%), with most of the remainder in VHDL and only trace
amounts in VLDL and LDL
3 PDB 3D structures from and Proteopedia for APOD:
2APD (3D)        2HZQ (3D)        2HZR (3D)    
Secondary accessions: B2R579 D3DNW6 Q6IBG6

Explore the universe of human proteins at neXtProt for APOD: NX_P05090

Explore proteomics data for APOD at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylatd. N-glycan heterogeneity at Asn-65: Hex5HexNAc4 (major) and Hex6HexNAc5 (minor); at Asn-98:
    Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major), dHex1Hex6HexNAc5 (minor) and dHex1Hex7HexNAc6 (minor)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P05090

  • APOD Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    APOD Protein Expression
    REFSEQ proteins: NP_001638.1  
    ENSEMBL proteins: 
     ENSP00000345179   ENSP00000391597   ENSP00000415235   ENSP00000393076  

    Human Recombinant Protein Products for APOD: 
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    Novus Biologicals APOD Proteins
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    Browse Sino Biological Recombinant Proteins
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    ProSpec Recombinant Protein for APOD
    Cloud-Clone Corp. Proteins for APOD 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005615extracellular space IDA--
    GO:0005622intracellular ----
    GO:0005783endoplasmic reticulum ISS--
    GO:0022626cytosolic ribosome ISS--

    APOD for ontologies           About GeneDecksing



    APOD Antibody Products: 
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    Cloud-Clone Corp. CLIAs for APOD


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    LCN: Lipocalins
    APOLIPO: Apolipoproteins

    5/8 InterPro protein domains (see all 8):
     IPR022271 Lipocalin_ApoD
     IPR022272 Lipocalin_CS
     IPR002969 ApolipopD
     IPR000566 Lipocln_cytosolic_FA-bd_dom
     IPR026222 ApoD_vertbrte

    Graphical View of Domain Structure for InterPro Entry P05090

    ProtoNet protein and cluster: P05090

    2 Blocks protein domains:
    IPB002345 Lipocalin signature
    IPB002969 Apolipoprotein D signature


    UniProtKB/Swiss-Prot: APOD_HUMAN, P05090
    Similarity: Belongs to the calycin superfamily. Lipocalin family


    APOD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APOD_HUMAN, P05090
    Function: APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably
    involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number
    of different contexts

         Genatlas biochemistry entry for APOD:
    apolipoprotein D (lipocalin family,Kernel group),widely distributed,occuring in macromolecular
    complexes,predominantly with APOA2 in HDL and APOB-100 in LDL and VLDL,identical to gross-cystic disease fluid
    progesterone/pregnelonone binding protein representing overhalf of the protein component of breast cyst fluid

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0005319lipid transporter activity NAS3453108
    GO:0005515protein binding IPI7918467
    GO:0008289lipid binding ----
    GO:0015485cholesterol binding IDA9278274
         
    APOD for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for APOD:
     Increased cell death in breast 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Apod):
     behavior/neurological  hearing/vestibular/ear  homeostasis/metabolism  mortality/aging  nervous system 

    APOD for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for APOD: Apodtm1Hhmd Apodtm1Dsan

       inGenious Targeting Laboratory - Custom generated mouse model solutions for APOD 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for APOD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for APOD 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for APOD 

    miRNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for APOD About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF)
    Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for APOD
        Cholesterol and Sphingolipids transport / Recycling to plasma membrane in lung (normal and CF)


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for APOD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/46 Interacting proteins for APOD (P050902, 3 ENSP000003451794) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYZAPP0CAP12, 3MINT-65205 I2D: score=4 
    STK24Q9Y6E03, ENSP000003657304I2D: score=2 STRING: ENSP00000365730
    APOA2P026523, ENSP000003569694I2D: score=2 STRING: ENSP00000356969
    LEPRP483573, ENSP000003303934I2D: score=3 STRING: ENSP00000330393
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000302response to reactive oxygen species IDA18419796
    GO:0001525angiogenesis NAS--
    GO:0006006glucose metabolic process IDA19176353
    GO:0006629lipid metabolic process IDA19176353
    GO:0006869lipid transport NAS3453108

    APOD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    APOD for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for APOD

    10/22 Novoseek inferred chemical compound relationships for APOD gene (see all 22)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arachidonic acid 52.8 39 15560970 (7), 14623496 (4), 7789516 (3), 19429117 (2) (see all 13)
    progesterone 48.1 24 1868457 (1), 11058760 (1), 12021176 (1), 16850244 (1) (see all 16)
    lipid 45.5 42 19519777 (4), 19723339 (3), 19176353 (2), 11274430 (1) (see all 21)
    dihydrotestosterone 42.6 4 7929425 (1), 19330472 (1)
    cholesterol 38.1 40 1582022 (3), 9422368 (3), 19429117 (2), 7789516 (2) (see all 13)
    clozapine 32 17 12363390 (3), 17011169 (3), 11274430 (1), 12911617 (1) (see all 5)
    cyanogen bromide 27.7 3 7918467 (1), 9659402 (1)
    steroid 26 14 1868457 (1), 7927949 (1), 7526888 (1), 11709627 (1) (see all 9)
    vitamin a 21.6 5 16461020 (2), 9278274 (1), 19390610 (1)
    estrogen 12.1 10 7929425 (1), 16850244 (1), 19107621 (1), 17589901 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about APOD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for APOD gene: 
    NM_001647.3  

    Unigene Cluster for APOD:

    Apolipoprotein D
    Hs.522555  [show with all ESTs]
    Unigene Representative Sequence: BF790155
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343267(uc003fur.2) ENST00000458447 ENST00000421243 ENST00000453131
    ENST00000463719(uc011bsx.1)

    miRNA
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    Additional mRNA sequence: 

    AK294523.1 AK312090.1 BC007402.2 BT019860.1 BT019861.1 CR456838.1 CR541773.1 J02611.1 
    S80440.1 

    17 DOTS entries:

    DT.450718  DT.97761904  DT.99954896  DT.91774835  DT.91774833  DT.91805361  DT.100827291  DT.120864970 
    DT.95166229  DT.95166241  DT.99943362  DT.100827294  DT.120864927  DT.120864975  DT.91774837  DT.95166228 
    DT.95166230 

    24/525 AceView cDNA sequences (see all 525):

    BF724291 AA363956 BQ434159 BI496609 H27940 BF475412 BM687438 BI755710 
    CD678334 BU731517 BQ678512 BM688920 AA033790 H44604 CD514591 CD679198 
    BQ425747 AI497793 CD172538 CA391787 CA397281 BQ270392 BM704656 BF724901 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    APOD expression in normal human tissues (normalized intensities)      APOD embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTACCCTG
    APOD Expression
    About this image


    APOD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 24 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Thalamus
             Brain Pericytes   
             Trigeminal Ganglion   
     
     Fibroblast
             Human Prostate Fibroblasts (HPrF)   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 9 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
             Normal Human Articular chondrocytes (NHAC)   
     
     Bone (Muscoskeletal System)    fully expand to see all 9 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Eye (Sensory Organs)    fully expand to see all 5 entries
             Retina
             Human corneal endothelial cells
             Human Trabecular Meshwork Cells (HTMC)   

    See APOD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for APOD

    SOURCE GeneReport for Unigene cluster: Hs.522555

    UniProtKB/Swiss-Prot: APOD_HUMAN, P05090
    Tissue specificity: Expressed in liver, intestine, pancreas, kidney, placenta, adrenal, spleen, fetal brain tissue
    and tears

        SABiosciences Expression via Pathway-Focused PCR Array including APOD: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for APOD gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Apod1 , 5 apolipoprotein D1, 5 78.49(n)1
    73.12(a)1
      16 (21.41 cM)5
    118151  NM_007470.31  NP_031496.21 
     312961925 
    chicken
    (Gallus gallus)
    Aves APOD1 apolipoprotein D 64.06(n)
    59.78(a)
      424893  NM_001011692.1  NP_001011692.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1233391 zgc:123339 57.5(n)
    51.46(a)
      567972  NM_001037695.1  NP_001032784.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta NLaz1 Neural Lazarillo 49.63(n)
    40.11(a)
      33324  NM_175946.1  NP_787960.1 


    ENSEMBL Gene Tree for APOD (if available)
    TreeFam Gene Tree for APOD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for APOD gene
    18/82 SIMAP similar genes for APOD using alignment to 4 protein entries:     APOD_HUMAN (see all proteins) (see all similar genes):
    AURA2    C10orf137    ZNF20    ZNF74    DCTN5    ZNF546
    ZNF585B    TMEM44    NSRP1    RUFY1    CFLAR    ERBB2
    ZNF547    UTY    PKN1    SHANK2    ZNF737    TMEM14B

    APOD for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/495 SNPs in APOD are shown (see all 495)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1163654241,2
    F--195295094(+) ATCTGG/AATTCA 1 -- int11Minor allele frequency- A:0.04WA 118
    rs782947521,2
    C,F--195295114(+) GAATAC/TGCCTT 1 -- int11Minor allele frequency- T:0.17WA 118
    rs757887051,2
    C,F--195295138(+) CCCCAC/TTCCAG 1 -- int12Minor allele frequency- T:0.20WA EA 238
    rs46776891,2
    C,F,A--195295166(+) TTAAAC/TGAGGA 1 -- int114Minor allele frequency- T:0.05NA WA CSA EA 514
    rs1809680961,2
    --195295206(+) ACTGCC/TTAAGG 1 -- int10--------
    rs2019969651,2
    --195295212(+) AAGGA-/TTTTTT 1 -- int10--------
    rs1430521221,2
    --195295243(+) AGGCAA/GGGTCT 1 -- int10--------
    rs1860617031,2
    --195295278(+) CAGTGG/TTGCCA 1 -- int10--------
    rs780015161,2
    C,F--195295296(+) TCACTG/ATACCC 1 -- int13Minor allele frequency- A:0.06WA CSA 122
    rs1386026101,2
    C--195295357(+) AGCACA/GGGTGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for APOD (195295573 - 195311076 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for APOD:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv878146CNV Loss21882294
    nsv878138CNV Gain21882294
    nsv428430CNV Gain+Loss18775914
    dgv1549e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): APOD
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing APOD
    DNA2.0 Custom Variant and Variant Library Synthesis for APOD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 107740    OMIM disorders: --

    20/45 diseases for APOD (see all 45):    About MalaCards
    anaplastic astrocytoma    breast cyst    male breast cancer    pilocytic astrocytoma
    gynecomastia    ganglioglioma    breast disease    neurofibroma
    niemann-pick disease    dermatofibrosarcoma    dermatofibrosarcoma protuberans    androgen insensitivity syndrome
    pick's disease    cutaneous malignant melanoma    astrocytoma    ductal carcinoma in situ
    oligodendroglioma    malignant peripheral nerve sheath tumor    bipolar disorder    gestational diabetes


    APOD for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/38 Novoseek inferred disease relationships for APOD gene (see all 38)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast male carcinoma 57.1 2 12678518 (1), 10504376 (1)
    pilocytic astrocytoma 53.8 7 11895042 (4), 16055749 (2)
    breast cysts 49.5 2 9075775 (2)
    niemann-picks disease type c 44.7 2 12646752 (1), 9422368 (1)
    breast cancer 40.5 52 8943263 (5), 17452772 (4), 19107621 (3), 12678530 (3) (see all 20)
    breast diseases 39.9 1 9293309 (1)
    neuropathology 39.3 12 9751198 (2), 11739619 (1), 14500696 (1), 18842892 (1) (see all 6)
    breast carcinoma 38.6 11 9307298 (2), 7929425 (1), 18505051 (1), 8943263 (1) (see all 7)
    ganglioglioma 37.6 2 16055749 (2)
    malignant peripheral nerve sheath tumors 36.4 3 15252314 (1), 16153462 (1)

    Genetic Association Database (GAD): APOD
    Human Genome Epidemiology (HuGE) Navigator: APOD (16 documents)

    Export disorders for APOD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for APOD gene, integrated from 9 sources (see all 199):
    (articles sorted by number of sources associating them with APOD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human apolipoprotein D gene: gene sequence, chromosome localization, and homology to the alpha 2u-globulin superfamily. (PubMed id 2439269)1, 2, 3 Drayna D.T....Lawn R.M. (1987)
    2. Cloning and expression of human apolipoprotein D cDNA. (PubMed id 3453108)1, 2, 3 Drayna D.T.... Lawn R.M. (1986)
    3. Apolipoprotein D is associated with long-term outcome in patients with schizophrenia. (PubMed id 16402085)1, 4, 9 Hansen T....Werge T. (2006)
    4. Apolipoprotein D levels are elevated in prefrontal cortex of subjects with Alzheimer's disease: no relation to apolipoprotein E expression or genotype. (PubMed id 12873803)1, 4, 9 Thomas E.A....Martins R.N. (2003)
    5. The human lacrimal gland synthesizes apolipoprotein D mRNA in addition to tear prealbumin mRNA, both species encoding members of the lipocalin superfamily. (PubMed id 8549691)1, 2, 9 Holzfeind P.... Redl B. (1995)
    6. Structure of human apolipoprotein D: locations of the intermolecular and intramolecular disulfide links. (PubMed id 7918467)1, 2, 9 Yang C.-Y.... Pownall H.J. (1994)
    7. Genetic variation in apolipoprotein D and Alzheimer's disease. (PubMed id 15316799)1, 4, 9 Helisalmi S....Soininen H. (2004)
    8. Genetic variation in apolipoprotein D affects the risk of Alzheimer disease in African-Americans. (PubMed id 12497622)1, 4, 9 Desai P.P....Kamboh M.I. (2003)
    9. Association between polymorphisms in the apolipoprotein D gene and sporadic Alzheimer's disease. (PubMed id 18671953)1, 4, 9 Chen Y....Jia J. (2008)
    10. Analysis of the association between Apolipoprotein D and schizophrenia. (PubMed id 16966838)1, 4, 9 Zhang X....He L. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 347 HGNC: 612 AceView: APOD Ensembl:ENSG00000189058 euGenes: HUgn347
    ECgene: APOD H-InvDB: APOD

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for APOD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for APOD gene:
    Search GeneIP for patents involving APOD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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