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Aliases for APOC4-APOC2 Gene

Subcategory (RNA class) for APOC4-APOC2 Gene

ncRNA

Quality Score for this RNA gene is

3

Aliases for APOC4-APOC2 Gene

  • APOC4-APOC2 Readthrough (NMD Candidate) 2 3
  • APOC4-APOC2 Readthrough 2

External Ids for APOC4-APOC2 Gene

Previous GeneCards Identifiers for APOC4-APOC2 Gene

  • GC19U901523
  • GC19P045446

Summaries for APOC4-APOC2 Gene

Entrez Gene Summary for APOC4-APOC2 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring apolipoprotein C-IV (APOC4) and apolipoprotein C-II (APOC2) genes on chromosome 19. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Mar 2011]

GeneCards Summary for APOC4-APOC2 Gene

APOC4-APOC2 (APOC4-APOC2 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOC4-APOC2 Gene

Genomics for APOC4-APOC2 Gene

Genomic Location for APOC4-APOC2 Gene

Start:
44,942,238 bp from pter
End:
44,949,565 bp from pter
Size:
7,328 bases
Orientation:
Plus strand

Genomic View for APOC4-APOC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APOC4-APOC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOC4-APOC2 Gene

No data available for Regulatory Elements for APOC4-APOC2 Gene

Proteins for APOC4-APOC2 Gene

  • Protein details for APOC4-APOC2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    K7ER74
    Recommended name:
    Protein APOC4-APOC2
    Protein Accession:
    K7ER74
    Secondary Accessions:

    Protein attributes for APOC4-APOC2 Gene

    Size:
    178 amino acids
    Molecular mass:
    20049 Da
    Quaternary structure:
    No Data Available

neXtProt entry for APOC4-APOC2 Gene

Proteomics data for APOC4-APOC2 Gene at MOPED

Post-translational modifications for APOC4-APOC2 Gene

No Post-translational modifications

Other Protein References for APOC4-APOC2 Gene

No data available for DME Specific Peptides for APOC4-APOC2 Gene

Domains for APOC4-APOC2 Gene

Protein Domains for APOC4-APOC2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with APOC4-APOC2: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for APOC4-APOC2 Gene

Function for APOC4-APOC2 Gene

Gene Ontology (GO) - Molecular Function for APOC4-APOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005319 lipid transporter activity --
GO:0008047 enzyme activator activity --
GO:0008289 lipid binding --
GO:0016004 phospholipase activator activity --
GO:0042803 protein homodimerization activity --
genes like me logo Genes that share ontologies with APOC4-APOC2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for APOC4-APOC2 Gene

Localization for APOC4-APOC2 Gene

Gene Ontology (GO) - Cellular Components for APOC4-APOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space --
GO:0005769 early endosome --
GO:0034361 very-low-density lipoprotein particle --
GO:0034362 low-density lipoprotein particle --
genes like me logo Genes that share ontologies with APOC4-APOC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for APOC4-APOC2 Gene

Pathways for APOC4-APOC2 Gene

SuperPathways for APOC4-APOC2 Gene

No Data Available

Interacting Proteins for APOC4-APOC2 Gene

Gene Ontology (GO) - Biological Process for APOC4-APOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process --
GO:0006629 lipid metabolic process --
GO:0006869 lipid transport --
GO:0007603 phototransduction, visible light --
GO:0010518 positive regulation of phospholipase activity --
genes like me logo Genes that share ontologies with APOC4-APOC2: view

No data available for Pathways by source for APOC4-APOC2 Gene

Transcripts for APOC4-APOC2 Gene

mRNA/cDNA for APOC4-APOC2 Gene

(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for APOC4-APOC2 Gene

No ASD Table

Relevant External Links for APOC4-APOC2 Gene

GeneLoc Exon Structure for
APOC4-APOC2
ECgene alternative splicing isoforms for
APOC4-APOC2

Expression for APOC4-APOC2 Gene

mRNA expression in normal human tissues for APOC4-APOC2 Gene

Protein differential expression in normal tissues for APOC4-APOC2 Gene

This gene is overexpressed in Serum (65.5).

Integrated Proteomics: protein expression from for APOC4-APOC2 Gene

genes like me logo Genes that share expressions with APOC4-APOC2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for APOC4-APOC2 Gene

Orthologs for APOC4-APOC2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for APOC4-APOC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia APOC4 36
  • 59 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 60 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Apoc4 36
  • 57 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 95 (a)
OneToMany
Species with no ortholog for APOC4-APOC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for APOC4-APOC2 Gene

ENSEMBL:
Gene Tree for APOC4-APOC2 (if available)
TreeFam:
Gene Tree for APOC4-APOC2 (if available)

Paralogs for APOC4-APOC2 Gene

Selected SIMAP similar genes for APOC4-APOC2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with APOC4-APOC2: view

No data available for Paralogs for APOC4-APOC2 Gene

Variants for APOC4-APOC2 Gene

Structural Variations from Database of Genomic Variants (DGV) for APOC4-APOC2 Gene

Variant ID Type Subtype PubMed ID
dgv3948n71 CNV Loss 21882294
nsv509747 CNV Insertion 20534489
nsv912133 CNV Loss 21882294
nsv912134 CNV Loss 21882294
nsv912140 CNV Gain 21882294

Relevant External Links for APOC4-APOC2 Gene

HapMap Linkage Disequilibrium report
APOC4-APOC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for APOC4-APOC2 Gene

Disorders for APOC4-APOC2 Gene

No disorders were found for APOC4-APOC2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for APOC4-APOC2 Gene

Publications for APOC4-APOC2 Gene

  1. Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus. (PMID: 8530039) Allan C.M. … Taylor J.M. (Genomics 1995) 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3

Products for APOC4-APOC2 Gene

Sources for APOC4-APOC2 Gene

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