Aliases for APOC4-APOC2 Gene
Subcategory (RNA class) for APOC4-APOC2 Gene
ncRNA
Quality Score for this RNA gene is
3
Aliases for APOC4-APOC2 Gene
External Ids for APOC4-APOC2 Gene
- HGNC: 44426
- Entrez Gene: 100533990
- Ensembl: ENSG00000224916
Previous GeneCards Identifiers for APOC4-APOC2 Gene
- GC19U901523
- GC19P045446
Summaries for APOC4-APOC2 Gene
-
This locus represents naturally occurring read-through transcription between the neighboring apolipoprotein C-IV (APOC4) and apolipoprotein C-II (APOC2) genes on chromosome 19. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Mar 2011]
GeneCards Summary for APOC4-APOC2 Gene
APOC4-APOC2 (APOC4-APOC2 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. GO annotations related to this gene include protein homodimerization activity and enzyme activator activity. An important paralog of this gene is APOC4.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOC4-APOC2 Gene
Genomics for APOC4-APOC2 Gene
Regulatory Elements for APOC4-APOC2 Gene
Enhancers for APOC4-APOC2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH19G044945 | 1.3 | Ensembl ENCODE | 0.7 | +3.7 | 3712 | 1.8 | ATF1 ARNT MLX ARID4B GLI4 DMAP1 ZNF48 YY1 ZNF121 GATA2 | APOC2 APOC4 APOC4-APOC2 |
| GH19G044943 | 1.2 | Ensembl ENCODE | 0.7 | +1.7 | 1732 | 0.6 | HDGF PKNOX1 ATF1 ARNT ZNF48 YY1 ELK1 ZNF592 CREB3 SMARCA4 | APOC2 APOC4 APOC4-APOC2 |
| GH19G044934 | 1.1 | ENCODE | 0.4 | -6.5 | -6463 | 2.9 | HDGF FOXA2 MLX CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 YY1 | ZNF180 FBXO46 ZNF155 APOC2 RELB CEACAM19 ENSG00000269148 ZNF224 ENSG00000266958 APOC1 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around APOC4-APOC2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for APOC4-APOC2 Gene
- Chromosome:
- 19
- Start:
- 44,942,238 bp from pter
- End:
- 44,949,565 bp from pter
- Size:
- 7,328 bases
- Orientation:
- Plus strand
Genomic View for APOC4-APOC2 Gene
Genes around APOC4-APOC2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.32 by Ensembl
- 19q13.32 by Entrez Gene
- 19q13.32 by HGNC
APOC4-APOC2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for APOC4-APOC2 Gene
Proteins for APOC4-APOC2 Gene
-
Protein details for APOC4-APOC2 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- A0A024R0T9
- Recommended name:
- Apolipoprotein C-II isoform 1
- Protein Accession:
- A0A024R0T9
Protein attributes for APOC4-APOC2 Gene
- Size:
- 101 amino acids
- Molecular mass:
- 11284 Da
- Quaternary structure:
- No Data Available
-
Protein details for APOC4-APOC2 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- K7ER74
- Recommended name:
- APOC4-APOC2 readthrough (NMD candidate)
- Protein Accession:
- K7ER74
Protein attributes for APOC4-APOC2 Gene
- Size:
- 178 amino acids
- Molecular mass:
- 20049 Da
- Quaternary structure:
- No Data Available
Protein Expression for APOC4-APOC2 Gene
Post-translational modifications for APOC4-APOC2 Gene
No Post-translational modifications
Other Protein References for APOC4-APOC2 Gene
- ENSEMBL proteins:
Antibody Products
- Search GeneTex for Antibodies for APOC4-APOC2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for APOC4-APOC2
- Origene Custom Protein Services for APOC4-APOC2
- Search GeneTex for Proteins for APOC4-APOC2
Assay Products
No data available for DME Specific Peptides for APOC4-APOC2 Gene
Domains & Families for APOC4-APOC2 Gene
Protein Domains for APOC4-APOC2 Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for APOC4-APOC2 Gene
Function for APOC4-APOC2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008047 | enzyme activator activity | IEA | -- |
Phenotypes for APOC4-APOC2 Gene
- GenomeRNAi human phenotypes for APOC4-APOC2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for APOC4-APOC2
-
- Search ViGene Biosciences for APOC4-APOC2
CRISPR Products
- Browse CRISPR knockouts for APOC4-APOC2
miRNA Products
- Search ViGene Biosciences for APOC4-APOC2
Inhibitory RNA Products
- Search ViGene Biosciences for APOC4-APOC2
Clone Products
- GenScript: Custom all cDNA clones Services for APOC4-APOC2
- VectorBuilder custom plasmid, inducible vectors for APOC4-APOC2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APOC4-APOC2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
- Search ViGene Biosciences for APOC4-APOC2
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for APOC4-APOC2 Gene
Localization for APOC4-APOC2 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 4 |
| endosome | 4 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0042627 | chylomicron | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for APOC4-APOC2 Gene
Pathways & Interactions for APOC4-APOC2 Gene
No Data Available
Interacting Proteins for APOC4-APOC2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006869 | lipid transport | IEA | -- |
| GO:0043085 | positive regulation of catalytic activity | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for APOC4-APOC2 Gene
Transcripts for APOC4-APOC2 Gene
mRNA/cDNA for APOC4-APOC2 Gene
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for APOC4-APOC2
miRNA Products
- Search ViGene Biosciences for APOC4-APOC2
Inhibitory RNA Products
- Search ViGene Biosciences for APOC4-APOC2
Clone Products
- GenScript: Custom all cDNA clones Services for APOC4-APOC2
- VectorBuilder custom plasmid, inducible vectors for APOC4-APOC2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APOC4-APOC2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Relevant External Links for APOC4-APOC2 Gene
- GeneLoc Exon Structure for
- APOC4-APOC2
- ECgene alternative splicing isoforms for
- APOC4-APOC2
Expression for APOC4-APOC2 Gene
This gene is overexpressed in Serum (65.5).
Evidence on tissue expression from TISSUES for APOC4-APOC2 Gene
- Liver(4.7)
- Lung(4.2)
- Muscle(4.2)
- Bone marrow(4)
Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for APOC4-APOC2 Gene
Orthologs for APOC4-APOC2 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | -- 35 |
|
OneToMany | |
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | APOC4 35 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Apoc4 35 |
|
OneToMany |
- Species where no ortholog for APOC4-APOC2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for APOC4-APOC2 Gene
- ENSEMBL:
- Gene Tree for APOC4-APOC2 (if available)
- TreeFam:
- Gene Tree for APOC4-APOC2 (if available)
Paralogs for APOC4-APOC2 Gene
Variants for APOC4-APOC2 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs120074111 | Pathogenic | 44,948,822(+) | CTGTA(A/C/G/T)GAGAA | nc-transcript-variant, reference, synonymous-codon, stop-gained | |
| rs120074112 | Pathogenic | 44,948,479(+) | ACACT(A/G)TGGGC | nc-transcript-variant, reference, missense | |
| rs120074114 | Pathogenic | 44,948,767(+) | GGTGA(A/C)GGAAT | nc-transcript-variant, reference, missense | |
| rs120074115 | Pathogenic | 44,948,787(+) | GTTAC(C/T)GGGAG | nc-transcript-variant, reference, missense | |
| rs120074116 | Pathogenic | 44,949,198(+) | ACTTA(A/C)ACAGG | nc-transcript-variant, reference, stop-gained |
Gene Damage Index Score:
1.79;
33.76% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for APOC4-APOC2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- APOC4-APOC2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOC4-APOC2 Gene
Disorders for APOC4-APOC2 Gene
Relevant External Links for APOC4-APOC2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- APOC4-APOC2
No disorders were found for APOC4-APOC2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APOC4-APOC2 Gene
Publications for APOC4-APOC2 Gene
- Genetic loci associated with circulating levels of very long-chain saturated fatty acids. (PMID: 25378659) Lemaitre R.N. … Friedlander Y. (J. Lipid Res. 2015) 3 64
- Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
- Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus. (PMID: 8530039) Allan C.M. … Taylor J.M. (Genomics 1995) 3 64
Products for APOC4-APOC2 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
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- Browse OriGene Antibodies
- Custom Antibody Services
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- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for APOC4-APOC2
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- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cyagen custom Knockout/knockin (KOKI) mouse models for APOC4-APOC2
- VectorBuilder custom plasmid, inducible vectors for APOC4-APOC2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APOC4-APOC2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for APOC4-APOC2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
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- (122) diseasecard
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- (141) ENCODE
- (142) ProSci
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- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer