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Aliases for APOC4-APOC2 Gene

Subcategory (RNA class) for APOC4-APOC2 Gene

ncRNA

Quality Score for this RNA gene is

3

Aliases for APOC4-APOC2 Gene

  • APOC4-APOC2 Readthrough (NMD Candidate) 2 3 5
  • APOC4-APOC2 Readthrough 2

External Ids for APOC4-APOC2 Gene

Previous GeneCards Identifiers for APOC4-APOC2 Gene

  • GC19U901523
  • GC19P045446

Summaries for APOC4-APOC2 Gene

Entrez Gene Summary for APOC4-APOC2 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring apolipoprotein C-IV (APOC4) and apolipoprotein C-II (APOC2) genes on chromosome 19. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Mar 2011]

GeneCards Summary for APOC4-APOC2 Gene

APOC4-APOC2 (APOC4-APOC2 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. GO annotations related to this gene include protein homodimerization activity and enzyme activator activity. An important paralog of this gene is APOC2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOC4-APOC2 Gene

Genomics for APOC4-APOC2 Gene

Regulatory Elements for APOC4-APOC2 Gene

Enhancers for APOC4-APOC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around APOC4-APOC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for APOC4-APOC2 Gene

Chromosome:
19
Start:
44,942,238 bp from pter
End:
44,949,565 bp from pter
Size:
7,328 bases
Orientation:
Plus strand

Genomic View for APOC4-APOC2 Gene

Genes around APOC4-APOC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOC4-APOC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOC4-APOC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOC4-APOC2 Gene

Proteins for APOC4-APOC2 Gene

  • Protein details for APOC4-APOC2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A024R0T9
    Recommended name:
    Apolipoprotein C-II isoform 1
    Protein Accession:
    A0A024R0T9

    Protein attributes for APOC4-APOC2 Gene

    Size:
    101 amino acids
    Molecular mass:
    11284 Da
    Quaternary structure:
    No Data Available
  • Protein details for APOC4-APOC2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    K7ER74
    Recommended name:
    Protein APOC4-APOC2
    Protein Accession:
    K7ER74

    Protein attributes for APOC4-APOC2 Gene

    Size:
    178 amino acids
    Molecular mass:
    20049 Da
    Quaternary structure:
    No Data Available

neXtProt entry for APOC4-APOC2 Gene

Proteomics data for APOC4-APOC2 Gene at MOPED

Post-translational modifications for APOC4-APOC2 Gene

No Post-translational modifications

Other Protein References for APOC4-APOC2 Gene

No data available for DME Specific Peptides for APOC4-APOC2 Gene

Domains & Families for APOC4-APOC2 Gene

Protein Domains for APOC4-APOC2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with APOC4-APOC2: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for APOC4-APOC2 Gene

Function for APOC4-APOC2 Gene

Phenotypes for APOC4-APOC2 Gene

GenomeRNAi human phenotypes for APOC4-APOC2:
genes like me logo Genes that share phenotypes with APOC4-APOC2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for APOC4-APOC2 Gene

Localization for APOC4-APOC2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for APOC4-APOC2 Gene

Pathways & Interactions for APOC4-APOC2 Gene

SuperPathways for APOC4-APOC2 Gene

No Data Available

Interacting Proteins for APOC4-APOC2 Gene

Gene Ontology (GO) - Biological Process for APOC4-APOC2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for APOC4-APOC2 Gene

Drugs & Compounds for APOC4-APOC2 Gene

No Compound Related Data Available

Transcripts for APOC4-APOC2 Gene

mRNA/cDNA for APOC4-APOC2 Gene

(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for APOC4-APOC2 Gene

No ASD Table

Relevant External Links for APOC4-APOC2 Gene

GeneLoc Exon Structure for
APOC4-APOC2
ECgene alternative splicing isoforms for
APOC4-APOC2

Expression for APOC4-APOC2 Gene

mRNA expression in normal human tissues for APOC4-APOC2 Gene

Protein differential expression in normal tissues from HIPED for APOC4-APOC2 Gene

This gene is overexpressed in Serum (65.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from for APOC4-APOC2 Gene



genes like me logo Genes that share expression patterns with APOC4-APOC2: view

Protein tissue co-expression partners for APOC4-APOC2 Gene

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for APOC4-APOC2 Gene

Orthologs for APOC4-APOC2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for APOC4-APOC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia APOC4 36
  • 59 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 60 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Apoc4 36
  • 57 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 95 (a)
OneToMany
Species with no ortholog for APOC4-APOC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for APOC4-APOC2 Gene

ENSEMBL:
Gene Tree for APOC4-APOC2 (if available)
TreeFam:
Gene Tree for APOC4-APOC2 (if available)

Paralogs for APOC4-APOC2 Gene

Paralogs for APOC4-APOC2 Gene

(2) SIMAP similar genes for APOC4-APOC2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with APOC4-APOC2: view

Variants for APOC4-APOC2 Gene

Structural Variations from Database of Genomic Variants (DGV) for APOC4-APOC2 Gene

Variant ID Type Subtype PubMed ID
dgv3948n71 CNV Loss 21882294
nsv509747 CNV Insertion 20534489
nsv912133 CNV Loss 21882294
nsv912134 CNV Loss 21882294
nsv912140 CNV Gain 21882294

Variation tolerance for APOC4-APOC2 Gene

Gene Damage Index Score: 1.79; 33.76% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for APOC4-APOC2 Gene

Disorders for APOC4-APOC2 Gene

Relevant External Links for APOC4-APOC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APOC4-APOC2

No disorders were found for APOC4-APOC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APOC4-APOC2 Gene

Publications for APOC4-APOC2 Gene

  1. Genetic loci associated with circulating levels of very long-chain saturated fatty acids. (PMID: 25378659) Lemaitre R.N. … Friedlander Y. (J. Lipid Res. 2015) 3 67
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus. (PMID: 8530039) Allan C.M. … Taylor J.M. (Genomics 1995) 3

Products for APOC4-APOC2 Gene

Sources for APOC4-APOC2 Gene

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