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Aliases for APOC4 Gene

Aliases for APOC4 Gene

  • Apolipoprotein C-IV 2 3
  • Apolipoprotein C4 3 4
  • APO-CIV 3 4
  • APOC-IV 3 4

External Ids for APOC4 Gene

Previous GeneCards Identifiers for APOC4 Gene

  • GC19P046090
  • GC19P045836
  • GC19P050115
  • GC19P050137
  • GC19P045445
  • GC19P041875

Summaries for APOC4 Gene

Entrez Gene Summary for APOC4 Gene

  • This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is thought to play a role in lipid metabolism. Polymorphisms in this gene may influence circulating lipid levels and may be associated with coronary artery disease risk. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring downstream apolipoprotein C-II (APOC2) gene. [provided by RefSeq, Mar 2011]

GeneCards Summary for APOC4 Gene

APOC4 (Apolipoprotein C-IV) is a Protein Coding gene. Diseases associated with APOC4 include artery disease and coronary artery disease. Among its related pathways are Statin Pathway. GO annotations related to this gene include lipid transporter activity. An important paralog of this gene is APOC4-APOC2.

UniProtKB/Swiss-Prot for APOC4 Gene

  • May participate in lipoprotein metabolism

Gene Wiki entry for APOC4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOC4 Gene

Genomics for APOC4 Gene

Regulatory Elements for APOC4 Gene

Genomic Location for APOC4 Gene

44,942,238 bp from pter
44,945,496 bp from pter
3,259 bases
Plus strand

Genomic View for APOC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APOC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOC4 Gene

Proteins for APOC4 Gene

  • Protein details for APOC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Apolipoprotein C-IV
    Protein Accession:
    Secondary Accessions:
    • B3KWY6
    • Q53YY8

    Protein attributes for APOC4 Gene

    127 amino acids
    Molecular mass:
    14553 Da
    Quaternary structure:
    No Data Available

neXtProt entry for APOC4 Gene

Proteomics data for APOC4 Gene at MOPED

Post-translational modifications for APOC4 Gene

  • Glycosylation at Asn63
  • Modification sites at PhosphoSitePlus

Other Protein References for APOC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for APOC4 Gene

Domains for APOC4 Gene

Gene Families for APOC4 Gene

Protein Domains for APOC4 Gene


Suggested Antigen Peptide Sequences for APOC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the apolipoprotein C4 family.
  • Belongs to the apolipoprotein C4 family.
genes like me logo Genes that share domains with APOC4: view

Function for APOC4 Gene

Molecular function for APOC4 Gene

GENATLAS Biochemistry:
apolipoprotein C-IV
UniProtKB/Swiss-Prot Function:
May participate in lipoprotein metabolism

Gene Ontology (GO) - Molecular Function for APOC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005319 lipid transporter activity TAS 8530039
genes like me logo Genes that share ontologies with APOC4: view

Phenotypes for APOC4 Gene

GenomeRNAi human phenotypes for APOC4:
genes like me logo Genes that share phenotypes with APOC4: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APOC4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for APOC4 Gene

Localization for APOC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOC4 Gene


Subcellular locations from

Jensen Localization Image for APOC4 Gene COMPARTMENTS Subcellular localization image for APOC4 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for APOC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034361 very-low-density lipoprotein particle IMP 8827523
GO:0034364 high-density lipoprotein particle IDA 12700345
genes like me logo Genes that share ontologies with APOC4: view

Pathways for APOC4 Gene

SuperPathways for APOC4 Gene

Superpath Contained pathways
1 Statin Pathway
genes like me logo Genes that share pathways with APOC4: view

Pathways by source for APOC4 Gene

1 BioSystems pathway for APOC4 Gene

Interacting Proteins for APOC4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000468236 for APOC4 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for APOC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 8530039
GO:0006869 lipid transport IEA --
GO:0010890 positive regulation of sequestering of triglyceride IMP 18809223
GO:0070328 triglyceride homeostasis IMP 8827523
genes like me logo Genes that share ontologies with APOC4: view

Transcripts for APOC4 Gene

mRNA/cDNA for APOC4 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(305) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for APOC4 Gene

Apolipoprotein C-IV:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for APOC4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for APOC4 Gene

No ASD Table

Relevant External Links for APOC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for APOC4 Gene

mRNA expression in normal human tissues for APOC4 Gene

Protein differential expression in normal tissues for APOC4 Gene

This gene is overexpressed in Serum (38.5), Synovial fluid (22.1), and Plasma (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for APOC4 Gene

SOURCE GeneReport for Unigene cluster for APOC4 Gene Hs.731599

mRNA Expression by UniProt/SwissProt for APOC4 Gene

Tissue specificity: Expressed by the liver and secreted in plasma
genes like me logo Genes that share expressions with APOC4: view

Expression partners for APOC4 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for APOC4 Gene

Orthologs for APOC4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for APOC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia APOC4 35
  • 74.02 (n)
  • 60.63 (a)
APOC4 36
  • 59 (a)
(Canis familiaris)
Mammalia APOC4 35
  • 76.81 (n)
  • 62.61 (a)
-- 36
  • 60 (a)
(Mus musculus)
Mammalia Apoc4 35
  • 70.7 (n)
  • 58.06 (a)
Apoc4 16
Apoc4 36
  • 57 (a)
(Pan troglodytes)
Mammalia APOC4 35
  • 97.9 (n)
  • 95.28 (a)
-- 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Apoc4 35
  • 73.39 (n)
  • 60.48 (a)
Species with no ortholog for APOC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for APOC4 Gene

Gene Tree for APOC4 (if available)
Gene Tree for APOC4 (if available)

Paralogs for APOC4 Gene

Paralogs for APOC4 Gene

(1) SIMAP similar genes for APOC4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with APOC4: view

Variants for APOC4 Gene

Sequence variations from dbSNP and Humsavar for APOC4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
VAR_012068 -
VAR_012069 -
VAR_012081 -
VAR_012082 -
VAR_036540 A breast cancer sample

Structural Variations from Database of Genomic Variants (DGV) for APOC4 Gene

Variant ID Type Subtype PubMed ID
dgv3948n71 CNV Loss 21882294
nsv509747 CNV Insertion 20534489
nsv912133 CNV Loss 21882294
nsv912134 CNV Loss 21882294
nsv912140 CNV Gain 21882294

Relevant External Links for APOC4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOC4 Gene

Disorders for APOC4 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for APOC4 Gene in MalaCards »

(3) Diseases for APOC4 Gene

Relevant External Links for APOC4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with APOC4: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for APOC4 Gene

Publications for APOC4 Gene

  1. Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus. (PMID: 8530039) Allan C.M. … Taylor J.M. (Genomics 1995) 2 3 4 23
  2. DNA sequence variation in human apolipoprotein C4 gene and its effect on plasma lipid profile. (PMID: 10996355) Kamboh M.I. … Hamman R.F. (Atherosclerosis 2000) 3 4 23
  3. Human apoC-IV: isolation, characterization, and immunochemical quantification in plasma and plasma lipoproteins. (PMID: 12700345) Kotite L. … Havel R.J. (J. Lipid Res. 2003) 3 23
  4. Expression of apolipoprotein C-IV is regulated by Ku antigen/peroxisome proliferator-activated receptor gamma complex and correlates with liver steatosis. (PMID: 18809223) Kim E. … Li J. (J. Hepatol. 2008) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for APOC4 Gene

Sources for APOC4 Gene

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