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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

APOC4 Gene

protein-coding GIFtS: 46
GCID: GC19P045445

apolipoprotein C-IV

Explore 8 diseases affiliated with
APOC4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Apolipoprotein C-IV¹ ²
Apolipoprotein C4² ³
APO-CIV²
APOC-IV²
Apo-CIV³
ApoC-IV³

External Ids:	HGNC: 611¹	Entrez Gene: 346²	Ensembl: ENSG00000267467⁷	OMIM: 600745⁵	UniProtKB: P55056³

ORGUL members:
	NONCODE:n410682

Export aliases for APOC4 gene to outside databases

Previous GC identifers: GC19P046090 GC19P045836 GC19P050115 GC19P050137 GC19P041875

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for APOC4:

This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is thought to play a

role in lipid metabolism. Polymorphisms in this gene may influence circulating lipid levels and may be associated with

coronary artery disease risk. This gene is present in a cluster with other related apolipoprotein genes on chromosome

19. Naturally occurring read-through transcription exists between this gene and the neighboring downstream

apolipoprotein C-II (APOC2) gene. (provided by RefSeq, Mar 2011)

UniProtKB/Swiss-Prot: APOC4_HUMAN, P55056

Function: May participate in lipoprotein metabolism

Gene Wiki entry for APOC4 (Apolipoprotein C4)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the APOC4 gene promoter:
Sox5 Pax-5 RREB-1 FOXD3 E2F E2F-1 NF-Y CBF(2) Ik-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: APOC4 promoter sequence

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOC4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.2

APOC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOC4 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P045445: view genomic region (about GC identifiers)

Start:	45,445,495 bp from pter	End:	45,448,753 bp from pter
Size:	3,259 bases	Orientation:	plus strand

1 alternative location:

Chr19+ 45,445,495-45,452,822

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
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About This Section

UniProtKB/Swiss-Prot: APOC4_HUMAN, P55056 (See protein sequence)

Recommended Name: Apolipoprotein C-IV precursor

Size: 127 amino acids; 14553 Da

Subcellular location: Secreted

Secondary accessions: B3KWY6 Q53YY8

Explore the universe of human proteins at neXtProt for APOC4: NX_P55056

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P55056

APOC4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001637.1

ENSEMBL proteins:

ENSP00000468236 ENSP00000466444

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0034361	very-low-density lipoprotein particle	IMP	8827523
GO:0034364	high-density lipoprotein particle	IDA	12700345

APOC4 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: P55056

UniProtKB/Swiss-Prot: APOC4_HUMAN, P55056

Similarity: Belongs to the apolipoprotein C4 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: APOC4_HUMAN, P55056

Function: May participate in lipoprotein metabolism

Genatlas biochemistry entry for APOC4:

apolipoprotein C-IV

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005319	lipid transporter activity	TAS	8530039

APOC4 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for APOC4:

Actin fiber cells

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for APOC4

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	TAS	8530039
GO:0006869	lipid transport	--	--
GO:0010890	positive regulation of sequestering of triglyceride	IMP	18809223
GO:0070328	triglyceride homeostasis	IMP	8827523

APOC4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for APOC4
Search CenterWatch for drugs/clinical trials and news about APOC4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for APOC4 gene:

NM_001646.2

Unigene Cluster for APOC4:

Apolipoprotein C-IV

Hs.731599 [show with all ESTs]

Unigene Representative Sequence: NR_037932

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000592954 ENST00000591600

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Additional cDNA sequence:

BC020723.1 EF371378.1 NR_037932.1

4 DOTS entries:

DT.448902 DT.310984 DT.95096683 DT.95096682

24/305 AceView cDNA sequences (see all 305):

BM680648 AI809022 NM_001646 AV659338 AV655381 T53749 AV681649 AV653106

AV645460 H58187 AA311868 AK126257 AW119216 BU149562 AV645463 M29844

T56264 AI333372 AV655400 AW014887 AV696790 X00568 AV659440 T57453

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

APOC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGACCTACT

About this image
See APOC4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for APOC4

SOURCE GeneReport for Unigene cluster: Hs.731599

UniProtKB/Swiss-Prot: APOC4_HUMAN, P55056

Tissue specificity: Expressed by the liver and secreted in plasma

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for APOC4 gene from 1/5 species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Apoc4^{1 , 5}	apolipoprotein C-IV^{1, 5}	71.24(n)¹ 58.06(a)¹		7 (9.94 cM)⁵ 11425¹ NM_007385.2¹ NP_031411.1¹ 19678094⁵

ENSEMBL Gene Tree for APOC4 (if available)
TreeFam Gene Tree for APOC4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs59859410^1,2	C,F,	--	45443504(+)	`GGCGCG/AGTGGC`	2	--	us2k¹		3		NA CSA	6
rs185585139^1,2		--	45443551(+)	`CGGGCA/GGATCA`	2	--	us2k¹		0	--	--	--	--
rs111809714^1,2	C,	--	45443647(+)	`GCGGGC/TGCCTG`	2	--	us2k¹		1		NA	2
rs188851230^1,2		--	45443699(+)	`GAACCC/TGGGAG`	2	--	us2k¹		0	--	--	--	--
rs191220812^1,2		--	45443729(+)	`GAGATC/TGCGCC`	2	--	us2k¹		0	--	--	--	--
rs183726624^1,2		--	45443762(+)	`AGAGCC/TAGACT`	2	--	us2k¹		0	--	--	--	--
rs111606839^1,2	C,	--	45443912(+)	`TGTTATTGTT/- TTGTT`	2	--	us2k¹		1		CSA	2
rs113438643^1,2		--	45443924(+)	`TGTTTT/CTGAGA`	2	--	us2k¹		2		CSA WA	120
rs71352241^1,2	C,	--	45443934(+)	`ACAAGG/TTCTCG`	2	--	us2k¹		1		NA	2
rs188537298^1,2		--	45443994(+)	`ACTACA/GTTGGC`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for APOC4 (45445495 - 45448753 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for APOC4: --
Human Gene Mutation Database (HGMD): APOC4

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

APOC4 for disorders           About GeneDecksing

OMIM gene information: 600745    OMIM disorders: --

8 diseases for APOC4:    About MalaCards

coronary heart disease hypertriglyceridemia hepatitis c hepatocellular carcinoma

hepatitis cholesterol carcinoma alcoholism

Genetic Association Database (GAD): APOC4
Human Genome Epidemiology (HuGE) Navigator: APOC4 (18 documents)

Export disorders for APOC4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for APOC4 gene, integrated from 9 sources (see all 36):
(articles sorted by number of sources associating them with APOC4)

Utopia: connect your pdf to the dynamic
world of online information

Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus. (PubMed id 8530039)^{1, 2, 3, 9} Allan C.M.... Taylor J.M. (1995)
DNA sequence variation in human apolipoprotein C4 gene and its effect on plasma lipid profile. (PubMed id 10996355)^{1, 2, 9} Kamboh M.I.... Hamman R.F. (2000)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Human apoC-IV: isolation, characterization, and immunochemical quantification in plasma and plasma lipoproteins. (PubMed id 12700345)^{1, 9} Kotite L....Havel R.J. (2003)
Expression of apolipoprotein C-IV is regulated by Ku antigen/peroxisome proliferator-activated receptor gamma complex and correlates with liver steatosis. (PubMed id 18809223)^{1, 9} Kim E....Li J. (2008)
Expression of a novel human apolipoprotein (apoC-IV) causes hypertriglyceridemia in transgenic mice. (PubMed id 8827523)^{1, 9} Allan C.M. and Taylor J.M. (1996)
Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C 4 genes are associated with multiple cardiovascular-related traits. (PubMed id 21943158)¹ Middelberg R.P....Whitfield J.B. (2011)
Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population. (PubMed id 20972250)¹ Park M.H....Park H.Y. (2011)
Genetic variants influencing circulating lipid levels and risk of coronary artery disease. (PubMed id 20864672)¹ Waterworth D.M....Sandhu M.S. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 346	HGNC: 611	AceView: APOC2andAPOC4	Ensembl:ENSG00000267467	euGenes: HUgn346
ECgene: APOC4	H-InvDB: APOC4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for APOC4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for APOC4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for APOC4 gene:
Search GeneIP for patents involving APOC4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOC4

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes APOC4 gene at Home site.

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APOC4 Gene

apolipoprotein C-IV

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APOC4 Gene

apolipoprotein C-IV

Aliasesfor APOC4 gene

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for APOC4 gene

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