Aliases for APOC4 Gene
External Ids for APOC4 Gene
- HGNC: 611
- Entrez Gene: 346
- Ensembl: ENSG00000267467
- OMIM: 600745
- UniProtKB: P55056
Previous GeneCards Identifiers for APOC4 Gene
- GC19P046090
- GC19P045836
- GC19P050115
- GC19P050137
- GC19P045445
- GC19P041875
Summaries for APOC4 Gene
-
This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is thought to play a role in lipid metabolism. Polymorphisms in this gene may influence circulating lipid levels and may be associated with coronary artery disease risk. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring downstream apolipoprotein C-II (APOC2) gene. [provided by RefSeq, Mar 2011]
GeneCards Summary for APOC4 Gene
APOC4 (Apolipoprotein C4) is a Protein Coding gene. Diseases associated with APOC4 include Artery Disease. Among its related pathways are Lipoprotein metabolism and Metabolism. GO annotations related to this gene include lipid transporter activity. An important paralog of this gene is APOC4-APOC2.
UniProtKB/Swiss-Prot for APOC4 Gene
-
May participate in lipoprotein metabolism.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOC4 Gene
Genomics for APOC4 Gene
Regulatory Elements for APOC4 Gene
Enhancers for APOC4 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around APOC4 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for APOC4 Gene
- Chromosome:
- 19
- Start:
- 44,942,238 bp from pter
- End:
- 44,945,496 bp from pter
- Size:
- 3,259 bases
- Orientation:
- Plus strand
Genomic View for APOC4 Gene
Genes around APOC4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.32 by Ensembl
- 19q13.32 by Entrez Gene
- 19q13.32 by HGNC
APOC4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for APOC4 Gene
Proteins for APOC4 Gene
-
Protein details for APOC4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P55056-APOC4_HUMAN
- Recommended name:
- Apolipoprotein C-IV
- Protein Accession:
- P55056
- B3KWY6
- Q53YY8
Protein attributes for APOC4 Gene
- Size:
- 127 amino acids
- Molecular mass:
- 14553 Da
- Quaternary structure:
- No Data Available
Protein Expression for APOC4 Gene
Post-translational modifications for APOC4 Gene
Other Protein References for APOC4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for APOC4
- Novus Biologicals Antibodies for APOC4
- Invitrogen Antibodies for APOC4
- antibodies-online Antibodies for APOC4: See all 32
- Search GeneTex for Antibodies for APOC4
-
Santa Cruz Biotechnology (SCBT) Antibodies for APOC4
Protein Products
-
OriGene Purified Proteins for APOC4
- Search Origene for MassSpec and Protein Over-expression Lysates for APOC4
- Origene Custom Protein Services for APOC4
- antibodies-online Proteins for APOC4: See all 11
- Search antibodies-online for peptides
- Search GeneTex for Proteins for APOC4
Assay Products
- antibodies-online Kits for APOC4: See all 41
No data available for DME Specific Peptides for APOC4 Gene
Domains & Families for APOC4 Gene
Gene Families for APOC4 Gene
- HGNC:
Suggested Antigen Peptide Sequences for APOC4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P55056- Family:
-
- Belongs to the apolipoprotein C4 family.
Function for APOC4 Gene
Molecular function for APOC4 Gene
- GENATLAS Biochemistry:
- apolipoprotein C-IV
- UniProtKB/Swiss-Prot Function:
- May participate in lipoprotein metabolism.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005319 | lipid transporter activity | TAS | 8530039 |
Phenotypes for APOC4 Gene
- MGI mutant phenotypes for APOC4:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for APOC4:
Animal Models for APOC4 Gene
- MGI Knock Outs for APOC4:
-
- Apoc4 tm1.1(KOMP)Mbp
Animal Model Products
-
Taconic Biosciences Mouse Models for APOC4
- Cyagen custom Knockout/knockin (KOKI) mouse models for APOC4
-
-
ViGene Biosciences lentiviral particle packaged cDNA for APOC4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for APOC4 gene
- Search ViGene Biosciences for APOC4
CRISPR Products
-
OriGene CRISPR knockouts for APOC4
-
Santa Cruz Biotechnology (SCBT) CRISPR for APOC4
- GenScript: Design CRISPR guide RNA sequences for APOC4
miRNA Products
- Search ViGene Biosciences for APOC4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for APOC4
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-
ViGene Biosciences ready-to-package AAV shRNAs for APOC4 gene
Clone Products
-
OriGene ORF clones in human for APOC4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for APOC4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APOC4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for APOC4
-
ViGene Biosciences adenoviral particle packaged cDNA for APOC4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for APOC4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for APOC4 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for APOC4 Gene
Localization for APOC4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for APOC4 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0034361 | very-low-density lipoprotein particle | IMP | 8827523 |
| GO:0034364 | high-density lipoprotein particle | IDA | 12700345 |
Pathways & Interactions for APOC4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Lipoprotein metabolism | ||
| 2 | Metabolism |
.37
|
|
Pathways by source for APOC4 Gene
6 Reactome pathways for APOC4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | TAS | 8530039 |
| GO:0006810 | transport | IEA | -- |
| GO:0006869 | lipid transport | IEA | -- |
| GO:0010890 | positive regulation of sequestering of triglyceride | IMP | 18809223 |
| GO:0034379 | very-low-density lipoprotein particle assembly | TAS | -- |
No data available for SIGNOR curated interactions for APOC4 Gene
Transcripts for APOC4 Gene
mRNA/cDNA for APOC4 Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (305) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for APOC4
-
Santa Cruz Biotechnology (SCBT) CRISPR for APOC4
- GenScript: Design CRISPR guide RNA sequences for APOC4
miRNA Products
- Search ViGene Biosciences for APOC4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for APOC4
- Browse OriGene Inhibitory RNA Products For APOC4
-
ViGene Biosciences ready-to-package AAV shRNAs for APOC4 gene
Clone Products
-
OriGene ORF clones in human for APOC4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for APOC4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APOC4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for APOC4 Gene
This gene is overexpressed in Serum (38.5), Synovial fluid (22.1), and Plasma (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for APOC4 Gene
NURSA nuclear receptor signaling pathways regulating expression of APOC4 Gene:
APOC4SOURCE GeneReport for Unigene cluster for APOC4 Gene:
Hs.731599mRNA Expression by UniProt/SwissProt for APOC4 Gene:
P55056-APOC4_HUMAN
Tissue specificity:
Expressed by the liver and secreted in plasma.
Evidence on tissue expression from TISSUES for APOC4 Gene
- Liver(4.2)
- Bone marrow(4)
- Lung(4)
Primer Products
-
OriGene qPCR primer pairs and template standards for APOC4
-
OriGene qPCR primer pairs for APOC4
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for APOC4 Gene
Orthologs for APOC4 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | APOC4 34 |
|
||
| -- 35 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | APOC4 34 |
|
||
| -- 35 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | APOC4 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Apoc4 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Apoc4 34 16 35 |
|
- Species where no ortholog for APOC4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for APOC4 Gene
Paralogs for APOC4 Gene
(1) SIMAP similar genes for APOC4 Gene using alignment to 3 proteins:
Variants for APOC4 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036540 | A breast cancer sample | ||||
| rs1000679121 | -- | 44,940,346(+) | ACCCC(A/G)TCTCT | upstream-variant-2KB | |
| rs1001298444 | -- | 44,943,164(+) | GATCC(A/G)CCTGC | intron-variant | |
| rs1001772246 | -- | 44,942,988(+) | GTGAT(A/C)TTGGC | intron-variant | |
| rs1001925585 | -- | 44,940,301(+) | ATCAC(A/G)AGGTC | upstream-variant-2KB |
Residual Variation Intolerance Score:
75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.27;
81.25% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for APOC4 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOC4 Gene
Disorders for APOC4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| artery disease |
|
|
Search APOC4 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for APOC4
No data available for UniProtKB/Swiss-Prot and Genatlas for APOC4 Gene
Publications for APOC4 Gene
- Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus. (PMID: 8530039) Allan C.M. … Taylor J.M. (Genomics 1995) 2 3 4 22 64
- DNA sequence variation in human apolipoprotein C4 gene and its effect on plasma lipid profile. (PMID: 10996355) Kamboh M.I. … Hamman R.F. (Atherosclerosis 2000) 3 4 22 64
- Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger T.L. … Thio C.L. (J. Infect. Dis. 2010) 3 46 64
- APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective coronary heart disease risk among UK healthy men. (PMID: 20498921) Ken-Dror G. … Drenos F. (Mol. Med. 2010) 3 46 64
- Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PMID: 20571754) Fontaine-Bisson B. … Franks P.W. (Diabetologia 2010) 3 46 64
Products for APOC4 Gene
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
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- Custom Antibody ServicesOriGene Antibodies for APOC4
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- Find your next knockout model in the Taconic Knockout Repository
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- Humanized Mice
- antibodies-online Antibodies for APOC4: See all 32
- antibodies-online Kits for APOC4: See all 41
- antibodies-online Proteins for APOC4: See all 11
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for APOC4
- Search GeneTex for Proteins for APOC4
- ViGene Biosciences adenoviral particle packaged cDNA for APOC4 gene
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- VectorBuilder custom plasmid, inducible vectors for APOC4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for APOC4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for APOC4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
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- (122) diseasecard
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- (141) ENCODE
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- (143) Horizon
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- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer