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APOC2 Gene

protein-coding   GIFtS: 61
GCID: GC19P045449

Apolipoprotein C-II

  See APOC2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Apolipoprotein C-II1 2     APC23
Apolipoprotein C22 3     Apo-CII3
APO-CII2     ApoC-II3
APOC-II2     

External Ids:    HGNC: 6091   Entrez Gene: 3442   Ensembl: ENSG000002349067   OMIM: 6080835   UniProtKB: P026553   

Export aliases for APOC2 gene to outside databases

Previous GC identifers: GC19P046094 GC19P045840 GC19P050125 GC19P050141 GC19P050138 GC19P041879


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for APOC2 Gene:
This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in
plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein
lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause
hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of
pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes
on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring
upstream apolipoprotein C-IV (APOC4) gene. (provided by RefSeq, Mar 2011)

GeneCards Summary for APOC2 Gene:
APOC2 (apolipoprotein C-II) is a protein-coding gene. Diseases associated with APOC2 include apolipoprotein c-ii deficiency, and hyperlipoproteinemia, type ib. GO annotations related to this gene include protein homodimerization activity and phospholipase binding.

UniProtKB/Swiss-Prot: APOC2_HUMAN, P02655
Function: Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several
triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a
function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly

Gene Wiki entry for APOC2 (Apolipoprotein C2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the APOC2 gene promoter:
         AhR   Sox5   Pax-5   RREB-1   GATA-1   Arnt   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAPOC2 promoter sequence
   Search Chromatin IP Primers for APOC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat APOC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.2

APOC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOC2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P045449:  view genomic region     (about GC identifiers)

Start:
45,449,239 bp from pter      End:
45,452,822 bp from pter
Size:
3,584 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: APOC2_HUMAN, P02655 (See protein sequence)
Recommended Name: Apolipoprotein C-II precursor  
Size: 101 amino acids; 11284 Da
4 PDB 3D structures from and Proteopedia for APOC2:
1BY6 (3D)        1I5J (3D)        1O8T (3D)        1SOH (3D)    
Secondary accessions: C0JYY4 Q9BS39 Q9UDE3 Q9UNK3

Explore the universe of human proteins at neXtProt for APOC2: NX_P02655

Explore proteomics data for APOC2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See APOC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000474.2  
    ENSEMBL proteins: 
     ENSP00000477261   ENSP00000476835   ENSP00000466775   ENSP00000465001   ENSP00000252490  
    Reactome Protein details: P02655

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    APOLIPO: Apolipoproteins

    2 InterPro protein domains:
     IPR023121 ApoC-II_domain
     IPR008019 Apo-CII

    Graphical View of Domain Structure for InterPro Entry P02655

    ProtoNet protein and cluster: P02655

    1 Blocks protein domain: IPB008019 Apolipoprotein C-II

    UniProtKB/Swiss-Prot: APOC2_HUMAN, P02655
    Similarity: Belongs to the apolipoprotein C2 family


    Find genes that share domains with APOC2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APOC2_HUMAN, P02655
    Function: Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several
    triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a
    function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly

         Genatlas biochemistry entry for APOC2:
    apolipoprotein C-II,component of VLDL,activator of several tri-acylglycerollipases

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008047enzyme activator activity ----
    GO:0008289lipid binding IDA10727238
    GO:0016004phospholipase activator activity IDA10727238
    GO:0042803protein homodimerization activity IMP8245722
    GO:0043274phospholipase binding IPI10727238
         
    Find genes that share ontologies with APOC2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for APOC2:
     Decreased nuclei size in G2M 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for APOC2
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    1 qRT-PCR Assays for microRNA that regulate APOC2:
    hsa-miR-328
    SwitchGear 3'UTR luciferase reporter plasmidAPOC2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    APOC2_HUMAN, P02655: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endosome4
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA10727238
    GO:0005769early endosome TAS--
    GO:0034361very-low-density lipoprotein particle IDA8245722
    GO:0034362low-density lipoprotein particle IDA8245722

    Find genes that share ontologies with APOC2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for APOC2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Statin Pathway
    Statin Pathway0.73
    Statin Pathway, Pharmacodynamics0.73
    2Lipoprotein metabolism
    Lipoprotein metabolism0.59
    Chylomicron-mediated lipid transport0.00
    Lipid digestion, mobilization, and transport0.59
    HDL-mediated lipid transport0.00
    3Diseases associated with visual transduction
    Visual phototransduction0.44
    Diseases associated with visual transduction0.43
    Retinoid metabolism and transport0.44
    4Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    5Signaling by GPCR
    Signal Transduction0.58


    Find genes that share SuperPaths with APOC2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for APOC2
        Statin Pathway


    3 Reactome Pathways for APOC2
        Retinoid metabolism and transport
    HDL-mediated lipid transport
    Chylomicron-mediated lipid transport

    1 PharmGKB Pathway for APOC2
        Statin Pathway, Pharmacodynamics

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for APOC2
    Interactions:

        GeneGlobe Interaction Network for APOC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for APOC2 (P026553 ENSP000002524904) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LPLP068583, ENSP000003097574I2D: score=2 STRING: ENSP00000309757
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    APOA1ENSP000002368504STRING: ENSP00000236850
    APOA2ENSP000003569694STRING: ENSP00000356969
    APOA4ENSP000003504254STRING: ENSP00000350425
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001523retinoid metabolic process TAS--
    GO:0006629lipid metabolic process ----
    GO:0006869lipid transport ----
    GO:0007603phototransduction, visible light TAS--
    GO:0010518positive regulation of phospholipase activity IDA10727238

    Find genes that share ontologies with APOC2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for APOC2

    Selected HMDB Compounds for APOC2 (see all 289)    About this table
    CompoundSynonyms CAS #PubMed Ids
    TG(10:0/10:0/10:0)[iso]Tri-n-caprin (see all 17)621-71-6--
    TG(12:0/12:0/12:0)Triacylglycerol (see all 11)----
    TG(15:0/16:0/20:2(11Z,14Z))[iso6]Tracylglycerol(15:0/16:0/20:2) (see all 15)----
    TG(15:0/16:0/20:3(8Z,11Z,14Z))[iso6]TAG(15:0/16:0/20:3n6) (see all 16)----
    TG(15:0/16:0/20:4(5Z,8Z,11Z,14Z))[iso6]TAG(15:0/16:0/20:4n6) (see all 15)----
    TG(15:0/18:0/18:2(9Z,12Z))[iso6]TG(15:0/18:0/18:2w6) (see all 15)----
    TG(15:0/18:0/18:3(9Z,12Z,15Z))[iso6]TAG(51:3) (see all 16)----
    TG(15:0/18:1(9Z)/16:0)[iso6]Tracylglycerol(15:0/18:1w9/16:0) (see all 15)----
    TG(15:0/18:1(9Z)/16:1(9Z))[iso6]TG(15:0/18:1/16:1) (see all 15)----
    TG(15:0/18:1(9Z)/18:1(9Z))[iso3]TG(15:0/18:1n9/18:1n9) (see all 15)----

    Selected Novoseek inferred chemical compound relationships for APOC2 gene (see all 30)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thioflavin t 68.4 8 10889036 (1), 12668464 (1), 19537801 (1), 11447233 (1) (see all 5)
    cholesterol 63.4 50 11990407 (2), 9829487 (2), 12364471 (2), 1452137 (2) (see all 31)
    lipid 63.4 66 9301634 (4), 14645070 (3), 10727238 (3), 10451384 (3) (see all 25)
    trioleoylglycerol 54 1 9421185 (1)
    dodecylphosphocholine 41.7 7 15209504 (4)
    triacylglycerol 38.3 7 9469593 (3), 17243549 (1), 15640456 (1), 20169943 (1) (see all 5)
    phospholipid 35.5 14 14645070 (3), 11311244 (2), 10335875 (1), 18005990 (1) (see all 10)
    rsai 33 4 7902280 (3)
    gemfibrozil 24.2 2 8847480 (1), 1814823 (1)
    heparin 22.8 1 12226739 (1)



    Find genes that share compounds with APOC2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for APOC2 gene: 
    NM_000483.4  

    Unigene Cluster for APOC2:

    Apolipoprotein C-II
    Hs.75615  [show with all ESTs]
    Unigene Representative Sequence: BG568052
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592257 ENST00000591597 ENST00000590360 ENST00000585786 ENST00000252490(uc021uvn.1)

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    hsa-miR-328
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    Additional mRNA sequence: 

    AF113884.1 BC005348.2 BT006708.1 M29844.1 X00568.1 

    5 DOTS entries:

    DT.448902  DT.91994966  DT.91764460  DT.91764455  DT.95269572 

    Selected AceView cDNA sequences (see all 305):

    AV645980 AV659440 AV650707 AV681730 AV659501 H58187 AA311868 AV653106 
    T53749 AI186675 AV655400 M29844 BM680648 N92119 AV659338 NM_000483 
    AV645463 AW014887 X00568 AI333372 AV659315 H66451 T56264 AI809022 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    APOC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCACTTACA
    APOC2 Expression
    About this image


    APOC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Hypoblast (Extraembryonic Tissues)
             Visceral Endoderm Cells Visceral Endoderm
     
     Yolk Sac (Extraembryonic Tissues)
             Visceral Endoderm Cells Visceral Endoderm
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Liver Lobule
             Hepatocyte-like cells
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced cells
    APOC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    APOC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75615

    UniProtKB/Swiss-Prot: APOC2_HUMAN, P02655
    Tissue specificity: Secreted in plasma

        Custom PCR Arrays for APOC2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for APOC2 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Apoc21 , 5 apolipoprotein C-II1, 5 73.54(n)1
    61.86(a)1
      7 (9.94 cM)5
    118131  NM_001277944.11  NP_001264873.11 
     196715845 


    ENSEMBL Gene Tree for APOC2 (if available)
    TreeFam Gene Tree for APOC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for APOC2 gene
    1 SIMAP similar gene for APOC2 using alignment to 4 protein entries:     APOC2_HUMAN (see all proteins):
    APOC4-APOC2

    Find genes that share paralogs with APOC2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    7 SNPs for APOC2    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0006404
    Hyperlipoproteinemia 1B (HLPP1B)4--see VAR_0006402 W R mis40--------
    rs1133292391,2
    C--45450410(+) TTGGAAA/-AAAAA 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs106224621,2
    C--45452269(+) cagccCCT/-cgtcc 1 -- cds11Minor allele frequency- -:0.50CSA 2
    rs1504489961,2
    C--45452694(+) CAAGG-/TGCCAA 1 -- ut310--------
    rs51221,2,4
    ----see VAR_0006412 mis40--------
    rs51261,2,4
    ----see VAR_0006422 mis40--------
    VAR_0006394
    ----see VAR_0006392 K T mis40--------

    HapMap Linkage Disequilibrium report for APOC2 (45449239 - 45452822 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for APOC2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912134CNV Loss21882294
    nsv912133CNV Loss21882294
    nsv912140CNV Gain21882294

    Human Gene Mutation Database (HGMD): APOC2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing APOC2
    DNA2.0 Custom Variant and Variant Library Synthesis for APOC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 608083   
    OMIM disorders: 207750  
    UniProtKB/Swiss-Prot: APOC2_HUMAN, P02655
  • Hyperlipoproteinemia 1B (HLPP1B) [MIM:207750]: Autosomal recessive trait characterized by
    hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. Note=The disease
    is caused by mutations affecting the gene represented in this entry

  • 11 diseases for APOC2:    
    About MalaCards
    apolipoprotein c-ii deficiency    hyperlipoproteinemia, type ib    chronic kidney failure    pancreatitis
    familial hyperlipidemia    hyperlipoproteinemia type v    hypertriglyceridemia    nontoxic goiter
    familial combined hyperlipidemia    steatorrhea    atherosclerosis

    3 diseases from the University of Copenhagen DISEASES database for APOC2:
    Myotonic dystrophy     Familial hyperlipidemia     Pancreatitis

    Find genes that share disorders with APOC2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for APOC2 gene (see all 27)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypertriglyceridemia 83 35 9126659 (3), 8163669 (2), 7902280 (2), 17018885 (2) (see all 22)
    endogenous hypertriglyceridemia 79.8 2 11905095 (1), 14663605 (1)
    hyperlipoproteinemia type v 73.9 2 2259550 (1), 1782747 (1)
    hypertriglyceridemias familial 71.3 4 10427620 (1), 12600078 (1), 16531747 (1), 17441893 (1)
    xanthoma 67.4 1 9665414 (1)
    hyperlipidemia 56.4 7 16200213 (1), 12600078 (1), 10727238 (1), 1782747 (1)
    pancreatitis 50.5 7 19034041 (2), 12120223 (1), 19534808 (1), 9665414 (1)
    hyperlipoproteinemia 50.1 2 7923858 (1)
    chronic pancreatitis 44.8 5 19034041 (2), 18936103 (1)
    acute pancreatitis 42.3 1 14663605 (1)

    Genatlas disease: APOC2
    hyperlipoproteinemia,type IB (CII deficiency)

    Genetic Association Database (GAD): APOC2
    Human Genome Epidemiology (HuGE) Navigator: APOC2 (31 documents)

    Export disorders for APOC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for APOC2 gene, integrated from 10 sources (see all 313):
    (articles sorted by number of sources associating them with APOC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of the apolipoprotein C-II gene during myelomonocytic differentiation of human leukemic cells. (PubMed id 11310852)1, 2, 9 Chun E.M.... Kim Y.H. (J. Leukoc. Biol. 2001)
    2. A missense mutation (Trp 26-->Arg) in exon 3 of the apolipoprotein CII gene in a patient with apolipoprotein CII deficiency (apo CII- Wakayama). (PubMed id 8323539)1, 2, 9 Inadera H.... Yoshida S. (Biochem. Biophys. Res. Commun. 1993)
    3. Sequence specific 1H-NMR assignments and secondary structure of a carboxy-terminal functional fragment of apolipoprotein CII. (PubMed id 1555583)1, 2, 9 Lycksell P.-O.... Graeslund A. (Eur. J. Biochem. 1992)
    4. Lipoprotein lipase mutation S447X associated with pancreatic calcification and steatorrhea in hyperlipidemic pancreatitis. (PubMed id 19034041)1, 4, 9 Chang Y.T....Wong J.M. (J. Clin. Gastroenterol. 2009)
    5. [Genetic polymorphism analysis of apolipoprotein CII microsatellite DNA (TG) n (AG) m in patients with coronary heart disease]. (PubMed id 11930616)1, 4, 9 Gao C....Yin Z. (Zhonghua Yi Xue Za Zhi 2001)
    6. Molecular cloning and characteristics of a new apolipoprotein C-II mutant identified in three unrelated individuals with hypercholesterolemia and hypertriglyceridemia. (PubMed id 8490626)1, 2, 9 Pullinger C.R....Kanr J.P. (Hum. Mol. Genet. 1993)
    7. A refined three-dimensional solution structure of a carboxy terminal fragment of apolipoprotein CII. (PubMed id 8112221)1, 2, 9 Oehman A.... Graeslund A. (Eur. Biophys. J. 1993)
    8. An apolipoprotein CII mutation, CII Lys-19-->Thr identified in patients with hyperlipidemia. (PubMed id 1782747)1, 2, 9 Hegele R.A.... Little J.A. (Dis. Markers 1991)
    9. Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis. (PubMed id 19878569)1, 4, 9 Chen S.N....Marian A.J. (BMC Med. Genet. 2009)
    10. The apolipoprotein C-II variant apoC-II Lys-19-->Thr is not associated with dyslipidemia in an affected kindred. (PubMed id 7923858)1, 2, 9 Zysow B.R.... Kane J.P. (Clin. Genet. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 344 HGNC: 609 AceView: APOC2andAPOC4 Ensembl:ENSG00000234906 euGenes: HUgn344
    ECgene: APOC2 H-InvDB: APOC2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for APOC2 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=APOC2[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for APOC2 gene:
    Search GeneIP for patents involving APOC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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