Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

APOC2 Gene

protein-coding GIFtS: 60
GCID: GC19P045449

apolipoprotein C-II

Explore 45 diseases affiliated with
APOC2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Apolipoprotein C-II¹ ²		APC2³
Apolipoprotein C2² ³		Apo-CII³
APO-CII²		ApoC-II³
APOC-II²

External Ids:	HGNC: 609¹	Entrez Gene: 344²	Ensembl: ENSG00000234906⁷	OMIM: 608083⁵	UniProtKB: P02655³

ORGUL members:
	NONCODE:n410682

Export aliases for APOC2 gene to outside databases

Previous GC identifers: GC19P046094 GC19P045840 GC19P050125 GC19P050141 GC19P050138 GC19P041879

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for APOC2:

This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in

plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase,

which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause

hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and

early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19.

Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein

C-IV (APOC4) gene. (provided by RefSeq, Mar 2011)

UniProtKB/Swiss-Prot: APOC2_HUMAN, P02655

Function: Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several

triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of

the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly

Gene Wiki entry for APOC2 (Apolipoprotein C2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the APOC2 gene promoter:
AhR Sox5 Pax-5 RREB-1 GATA-1 Arnt NF-Y CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: APOC2 promoter sequence

Search SABiosciences Chromatin IP Primers for APOC2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOC2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.2

APOC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOC2 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P045449: view genomic region (about GC identifiers)

Start:	45,449,243 bp from pter	End:	45,452,822 bp from pter
Size:	3,580 bases	Orientation:	plus strand

1 alternative location:

Chr19+ 45,445,495-45,452,822

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: APOC2_HUMAN, P02655 (See protein sequence)

Recommended Name: Apolipoprotein C-II precursor

Size: 101 amino acids; 11284 Da

Subcellular location: Secreted

4 PDB 3D structures from and Proteopedia for APOC2:

1BY6 (3D)

1I5J (3D)

1O8T (3D)

1SOH (3D)

Secondary accessions: C0JYY4 Q9BS39 Q9UDE3 Q9UNK3

Explore the universe of human proteins at neXtProt for APOC2: NX_P02655

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P02655

APOC2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000474.2

ENSEMBL proteins:

ENSP00000466775 ENSP00000465001

Reactome Protein details: P02655
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: APOC2 OriGene Protein Over-expression Lysate: APOC2 OriGene Custom Protein Services for APOC2
	GenScript Custom Purified and Recombinant Proteins Services for APOC2
	Novus Biologicals APOC2 Proteins Novus Biologicals APOC2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for APOC2

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IDA	10727238
GO:0034361	very-low-density lipoprotein particle	IDA	8245722
GO:0034362	low-density lipoprotein particle	IDA	8245722
GO:0034363	intermediate-density lipoprotein particle	IDA	17336988

APOC2 for ontologies About GeneDecksing

APOC2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for APOC2 (Apolipoprotein C-II/ApoC2)
	Browse OriGene Antibodies OriGene Custom Antibody Services for APOC2
	GenScript Superior Antibodies for APOC2
	Novus Biologicals APOC2 Antibodies
	Search for Antibodies for APOC2 at Abcam
	Uscn Antibodies for APOC2
	ThermoFisher Antibodies for APOC2

Assay Products for APOC2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for APOC2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for APOC2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

APOC2 for domains About GeneDecksing

2 InterPro domains/families:

IPR023121 ApoC-II_domain

IPR008019 Apo-CII

Graphical View of Domain Structure for InterPro Entry P02655

ProtoNet protein and cluster: P02655

1 Blocks protein family: IPB008019 Apolipoprotein C-II

UniProtKB/Swiss-Prot: APOC2_HUMAN, P02655

Similarity: Belongs to the apolipoprotein C2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: APOC2_HUMAN, P02655

Function: Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several

triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of

the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly

Genatlas biochemistry entry for APOC2:

apolipoprotein C-II,component of VLDL,activator of several tri-acylglycerollipases

miRNA Products:		OriGene 3'-UTR Clone: APOC2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APOC2
		1 QIAGEN miScript miRNA Assays for microRNA that regulate APOC2:
		hsa-miR-328
		SwitchGear 3'UTR luciferase reporter plasmid: APOC2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APOC2 (see all 7) OriGene shRNA RFP: APOC2 OriGene siRNA: APOC2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APOC2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for APOC2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APOC2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APOC2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: APOC2 (NM_000483)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for APOC2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOC2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for APOC2
		Search LifeMap BioReagents cell lines for APOC2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOC2

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008289	lipid binding	IDA	10727238
GO:0016004	phospholipase activator activity	IDA	10727238
GO:0042803	protein homodimerization activity	IMP	8245722
GO:0043274	phospholipase binding	IPI	10727238
GO:0055102	lipase inhibitor activity	IDA	182536

APOC2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for APOC2:

Decreased nuclei size in G2M

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Lipoprotein metabolism

	Lipoprotein metabolism	1.00			Chylomicron-mediated lipid transport	0.57
	HDL-mediated lipid transport	0.57			Lipid digestion, mobilization, and transport	0.56

Retinoid metabolism and transport

	Retinoid metabolism and transport	1.00			Diseases associated with visual transduction	0.73
	Visual phototransduction	0.74

Metabolism

Metabolism

1.00

Metabolism of lipids and lipoproteins

0.34

Statin Pathway, Pharmacodynamics

Statin Pathway, Pharmacodynamics

1.00

Statin Pathway

0.80

Disease

Disease

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for APOC2

Statin Pathway

5/11 Reactome Pathways for APOC2 (see all 11)

	Diseases associated with visual transduction
	Metabolism
	Chylomicron-mediated lipid transport
	Visual phototransduction
	Disease

1 PharmGKB Pathway for APOC2

Statin Pathway, Pharmacodynamics

APOC2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for APOC2

2 Interacting proteins for APOC2 (P02655³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LPL	P06858³	I2D: score=2
ALB	P02768³	I2D: score=1

About this table

Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	TAS	--
GO:0010518	positive regulation of phospholipase activity	IDA	10727238
GO:0010898	positive regulation of triglyceride catabolic process	IDA	10727238
GO:0010902	positive regulation of very-low-density lipoprotein particle remodeling	IC	10727238
GO:0010916	negative regulation of very-low-density lipoprotein particle clearance	IDA	1917954

APOC2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

APOC2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for APOC2

10/289 HMDB Compounds for APOC2 (see all 289) About this table

Compound	Synonyms	CAS #	PubMed Ids
TG(10:0/10:0/10:0)[iso]	Tri-n-caprin (see all 17)	621-71-6	--
TG(12:0/12:0/12:0)	Triacylglycerol (see all 11)	--	--
TG(15:0/16:0/20:2(11Z,14Z))[iso6]	Tracylglycerol(15:0/16:0/20:2) (see all 15)	--	--
TG(15:0/16:0/20:3(8Z,11Z,14Z))[iso6]	TAG(15:0/16:0/20:3n6) (see all 16)	--	--
TG(15:0/16:0/20:4(5Z,8Z,11Z,14Z))[iso6]	TAG(15:0/16:0/20:4n6) (see all 15)	--	--
TG(15:0/18:0/18:2(9Z,12Z))[iso6]	TG(15:0/18:0/18:2w6) (see all 15)	--	--
TG(15:0/18:0/18:3(9Z,12Z,15Z))[iso6]	TAG(51:3) (see all 16)	--	--
TG(15:0/18:1(9Z)/16:0)[iso6]	Tracylglycerol(15:0/18:1w9/16:0) (see all 15)	--	--
TG(15:0/18:1(9Z)/16:1(9Z))[iso6]	TG(15:0/18:1/16:1) (see all 15)	--	--
TG(15:0/18:1(9Z)/18:1(9Z))[iso3]	TG(15:0/18:1n9/18:1n9) (see all 15)	--	--

10/30 Novoseek chemical compound relationships for APOC2 gene (see all 30) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
thioflavin t	68.4	8	10889036 (1), 12668464 (1), 19537801 (1), 11447233 (1) (see all 5)
cholesterol	63.4	50	11990407 (2), 9829487 (2), 12364471 (2), 1452137 (2) (see all 31)
lipid	63.4	66	9301634 (4), 14645070 (3), 10727238 (3), 10451384 (3) (see all 25)
trioleoylglycerol	54	1	9421185 (1)
dodecylphosphocholine	41.7	7	15209504 (4)
triacylglycerol	38.3	7	9469593 (3), 17243549 (1), 15640456 (1), 20169943 (1) (see all 5)
phospholipid	35.5	14	14645070 (3), 11311244 (2), 10335875 (1), 18005990 (1) (see all 10)
rsai	33	4	7902280 (3)
gemfibrozil	24.2	2	8847480 (1), 1814823 (1)
heparin	22.8	1	12226739 (1)

Search CenterWatch for drugs/clinical trials and news about APOC2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for APOC2 gene:

NM_000483.4

Unigene Cluster for APOC2:

Apolipoprotein C-II

Hs.75615 [show with all ESTs]

Unigene Representative Sequence: BG568052

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000590360 ENST00000585786

miRNA Products:		OriGene 3'-UTR Clone: APOC2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APOC2
		1 QIAGEN miScript miRNA Assays for microRNA that regulate APOC2:
		hsa-miR-328
		SwitchGear 3'UTR luciferase reporter plasmid: APOC2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APOC2 (see all 7) OriGene shRNA RFP: APOC2 OriGene siRNA: APOC2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APOC2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APOC2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APOC2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: APOC2 (NM_000483)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for APOC2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOC2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for APOC2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat APOC2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APOC2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APOC2

Additional cDNA sequence:

AF113884.1 BC005348.2 BT006708.1 M29844.1 X00568.1

5 DOTS entries:

DT.448902 DT.91994966 DT.91764460 DT.91764455 DT.95269572

24/305 AceView cDNA sequences (see all 305):

AV654399 T53749 NM_000483 AV653091 AV681649 AV653106 AV647124 BX956714

AW014887 H58187 AW119216 CK300640 AV650707 AF113884 AV645460 AV655400

T56264 AI333372 AK126257 AA311868 AV645463 M29844 BU149562 AV696790

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

APOC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCACTTACA

About this image

APOC2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See APOC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for APOC2

SOURCE GeneReport for Unigene cluster: Hs.75615

UniProtKB/Swiss-Prot: APOC2_HUMAN, P02655

Tissue specificity: Secreted in plasma

SABiosciences Custom PCR Arrays for APOC2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for APOC2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat APOC2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APOC2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APOC2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOC2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for APOC2 gene from 1/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Apoc2^{1 , 5}	apolipoprotein C-II^{1, 5}	73.54(n)¹ 61.86(a)¹		7 (9.94 cM)⁵ 11813¹ NM_009695.3¹ NP_033825.1¹ 19671584⁵

ENSEMBL Gene Tree for APOC2 (if available)
TreeFam Gene Tree for APOC2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs120074114^1,2	C,F,	pathogenic	45452024(+)	`GGTGAA/CGGAAT`	3	K T	mis¹		2		NA EU	5865
rs120074111^1,2	C	pathogenic	45452079(+)	`CTGTAA/C/G/T GAGAA`	7	* Y	stg¹ syn¹		0	--	--	--	--
rs5122^1,2	C,F,H,	pathogenic	45452080(+)	`TGTACG/AAGAAG`	3	/K /E	mis¹		10		MN NS EA NA	5442
rs5126^1,2	C,F,H,	pathogenic	45452429(+)	`ACAGCA/CAAAGC`	3	K Q	nc-transcript-variantmis¹		9		MN NS EA NA WA EU	6357
rs12721108^1,2	C,F,H,	--	45447241(+)	`GGCCCG/TGAAAG`	3	--	int¹ us2k¹		9		NS EA NA	804
rs12721106^1,2	C,H	--	45447291(+)	`GGGCAG/AAAAGT`	3	--	int¹ us2k¹		6		NS EA	648
rs12721107^1,2	C,F,H,	--	45447305(+)	`CTCCTG/TCTCTC`	3	--	us2k¹ int¹		7		NS EA NA	600
rs12709883^1,2	C,H	--	45447424(+)	`GAGGAT/CGGCAA`	3	--	us2k¹ int¹		8		NS EA NA	748
rs5159^1,2	C,F,H,	--	45447509(+)	`GGCCCA/GGCCGG`	3	--	int¹ us2k¹		9		MN NS EA CSA WA	806
rs5160^1,2	F	--	45447540(+)	`aatccC/Tagcat`	3	--	us2k¹ int¹		1		MN	68

HapMap Linkage Disequilibrium report for APOC2 (45449243 - 45452822 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for APOC2: --
Human Gene Mutation Database (HGMD): APOC2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing APOC2

DNA2.0 Custom Variant and Variant Library Synthesis for APOC2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

APOC2 for disorders           About GeneDecksing

OMIM gene information: 608083
OMIM disorders: 207750
UniProtKB/Swiss-Prot: APOC2_HUMAN, P02655

Defects in APOC2 are the cause of hyperlipoproteinemia type 1B (HLPP1B) [MIM:207750]. It is an autosomal

recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early

atherosclerosis

20/45 diseases for APOC2 (see all 45): About MalaCards

hyperlipoproteinemia, type ib hyperlipoproteinemia hypertriglyceridemia lipoprotein lipase deficiency

apolipoprotein c-ii deficiency hyperlipoproteinemia type v familial lipoprotein lipase deficiency atherosclerosis

pancreatitis retinol binding protein maturity-onset diabetes of the young patent ductus arteriosus

familial combined hyperlipidemia coronary heart disease chylomicronemia syndrome hyperlipidemia

chronic kidney failure myotonic dystrophy diabetes mellitus steatorrhea

3 diseases from the University of Copenhagen DISEASES database for APOC2:

Myotonic dystrophy Familial hyperlipidemia Pancreatitis

10/27 Novoseek disease relationships for APOC2 gene (see all 27) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hypertriglyceridemia	83	35	9126659 (3), 8163669 (2), 7902280 (2), 17018885 (2) (see all 22)
endogenous hypertriglyceridemia	79.8	2	11905095 (1), 14663605 (1)
hyperlipoproteinemia type v	73.9	2	2259550 (1), 1782747 (1)
hypertriglyceridemias familial	71.3	4	10427620 (1), 12600078 (1), 16531747 (1), 17441893 (1)
xanthoma	67.4	1	9665414 (1)
hyperlipidemia	56.4	7	16200213 (1), 12600078 (1), 10727238 (1), 1782747 (1)
pancreatitis	50.5	7	19034041 (2), 12120223 (1), 19534808 (1), 9665414 (1)
hyperlipoproteinemia	50.1	2	7923858 (1)
chronic pancreatitis	44.8	5	19034041 (2), 18936103 (1)
acute pancreatitis	42.3	1	14663605 (1)

Genatlas disease: APOC2

hyperlipoproteinemia,type IB (CII deficiency)

Genetic Association Database (GAD): APOC2
Human Genome Epidemiology (HuGE) Navigator: APOC2 (31 documents)

Export disorders for APOC2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for APOC2 gene, integrated from 9 sources (see all 310):
(articles sorted by number of sources associating them with APOC2)

Utopia: connect your pdf to the dynamic
world of online information

Expression of the apolipoprotein C-II gene during myelomonocytic differentiation of human leukemic cells. (PubMed id 11310852)^{1, 2, 9} Chun E.M.... Kim Y.H. (2001)
A missense mutation (Trp 26-->Arg) in exon 3 of the apolipoprotein CII gene in a patient with apolipoprotein CII deficiency (apo CII- Wakayama). (PubMed id 8323539)^{1, 2, 9} Inadera H.... Yoshida S. (1993)
Sequence specific 1H-NMR assignments and secondary structure of a carboxy-terminal functional fragment of apolipoprotein CII. (PubMed id 1555583)^{1, 2, 9} Lycksell P.-O.... Graeslund A. (1992)
[Genetic polymorphism analysis of apolipoprotein CII microsatellite DNA (TG) n (AG) m in patients with coronary heart disease] (PubMed id 11930616)^{1, 4, 9} Gao C....Yin Z. (2001)
Molecular cloning and characteristics of a new apolipoprotein C-II mutant identified in three unrelated individuals with hypercholesterolemia and hypertriglyceridemia. (PubMed id 8490626)^{1, 2, 9} Pullinger C.R....Kanr J.P. (1993)
A refined three-dimensional solution structure of a carboxy terminal fragment of apolipoprotein CII. (PubMed id 8112221)^{1, 2, 9} Oehman A.... Graeslund A. (1993)
An apolipoprotein CII mutation, CII Lys-19-->Thr identified in patients with hyperlipidemia. (PubMed id 1782747)^{1, 2, 9} Hegele R.A.... Little J.A. (1991)
The apolipoprotein C-II variant apoC-II Lys-19-->Thr is not associated with dyslipidemia in an affected kindred. (PubMed id 7923858)^{1, 2, 9} Zysow B.R.... Kane J.P. (1994)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Apolipoprotein molecular variation in Moroccan Berbers: pentanucleotide (TTTTA)n repeat in the LPA gene and APOE-C1-C2 gene cluster. (PubMed id 12220441)^{1, 4} Harich N....Moral P. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 344	HGNC: 609	AceView: APOC2andAPOC4	Ensembl:ENSG00000234906	euGenes: HUgn344
ECgene: APOC2	H-InvDB: APOC2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for APOC2	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/APOC2

Intellectual Property for APOC2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for APOC2 gene:
Search GeneIP for patents involving APOC2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for APOC2 (Apolipoprotein C-II/ApoC2)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for APOC2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for APOC2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for APOC2
	OriGene Protein Over-expression Lysate for APOC2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for APOC2		OriGene 3'-UTR Clone for APOC2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for APOC2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for APOC2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for APOC2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for APOC2		OriGene Custom Protein Services for APOC2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat APOC2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing APOC2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOC2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat APOC2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APOC2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat APOC2

	GenScript Custom Purified and Recombinant Proteins Services for APOC2		GenScript cDNA clones with any tag delivered in your preferred vector for APOC2
	GenScript Custom Assay Services for APOC2		GenScript Superior Antibodies for APOC2
	GenScript Custom overexpressing Cell Line Services for APOC2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in APOC2 promoter
	Search Chromatin IP Primers for APOC2
	RT² qPCR Primer Assay in human, mouse, rat APOC2
	GNC Network for APOC2
	SABiosciences Custom PCR Arrays for APOC2

Search Tocris compounds for APOC2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	APOC2 antibodies
	APOC2 proteins
	APOC2 lysates

	Search for Antibodies for APOC2 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for APOC2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

APOC2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for APOC2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOC2

	SwitchGear 3'UTR luciferase reporter plasmids for APOC2
	SwitchGear Promoter luciferase reporter plasmids for APOC2

ThermoFisher Antibodies for APOC2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOC2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes APOC2 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

APOC2 Gene

apolipoprotein C-II

Aliases
for APOC2 gene

Summaries
for APOC2 gene

Genomic Views
for APOC2 gene

Proteins
for APOC2 gene

Protein Domains /
Families
for APOC2 gene

Function
for APOC2 gene

Pathways & Interactions
for APOC2 gene

Drugs & Compounds
for APOC2 gene

Transcripts
for APOC2 gene

Expression
for APOC2 gene

Orthologs
for APOC2 gene

Paralogs
for APOC2 gene

Genomic Variants
for APOC2 gene

Disorders / Diseases
for APOC2 gene

Publications
for APOC2 gene

External Searches for APOC2 gene

Genome Databases showing APOC2 gene

Other Databases showing APOC2 gene

Specialized Databases showing APOC2 gene

Intellectual Property
for APOC2 gene

Products
for APOC2 gene

View Random Gene

Pancreatitis
acute pancreatitis
impaired glucose tolerance
Multiple Sclerosis
atherosclerotic plaque
Hyperlipoproteinemia Type V
Inflammation
Hypertriglyceridemia
Xanthoma
Proteinuria
Hyperlipidemia
Hypertriglyceridemias Familial
Alzheimers Disease
Atherosclerosis
Diabetes Mellitus
Hyperlipoproteinemia
ENDOGENOUS HYPERTRIGLYCERIDEMIA
Vascular Diseases
Tumors
Cardiovascular Diseases
Hypercholesterolemia
Necrosis
NIDDM
genetic disorder
Coronary Heart Disease
chronic pancreatitis
Renal Failure Chronic

Advanced Search

Export list of displayed genes

APOC2 Gene

apolipoprotein C-II

Aliasesfor APOC2 gene

Summariesfor APOC2 gene

Genomic Viewsfor APOC2 gene

Proteinsfor APOC2 gene

Protein Domains /Familiesfor APOC2 gene

Functionfor APOC2 gene

Pathways & Interactionsfor APOC2 gene

Drugs & Compoundsfor APOC2 gene

Transcriptsfor APOC2 gene

Expression for APOC2 gene

Orthologsfor APOC2 gene

Paralogsfor APOC2 gene

Genomic Variantsfor APOC2 gene

Disorders / Diseasesfor APOC2 gene

Publicationsfor APOC2 gene

External Searches for APOC2 gene

Genome Databases showing APOC2 gene

Other Databases showing APOC2 gene

Specialized Databases showing APOC2 gene

Intellectual Propertyfor APOC2 gene

Productsfor APOC2 gene

View Random Gene

Aliases
for APOC2 gene

Summaries
for APOC2 gene

Genomic Views
for APOC2 gene

Proteins
for APOC2 gene

Protein Domains /
Families
for APOC2 gene

Function
for APOC2 gene

Pathways & Interactions
for APOC2 gene

Drugs & Compounds
for APOC2 gene

Transcripts
for APOC2 gene

Expression
for APOC2 gene

Orthologs
for APOC2 gene

Paralogs
for APOC2 gene

Genomic Variants
for APOC2 gene

Disorders / Diseases
for APOC2 gene

Publications
for APOC2 gene

Intellectual Property
for APOC2 gene

Products
for APOC2 gene