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Aliases & Descriptions for APOC1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| apolipoprotein C-I 2 |
|
| | Search outside databases for aliases for APOC1 genePrevious GC identifers: GC19P046062 GC19P045808 GC19P050093 |
Summaries for APOC1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for APOC1: The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq] UniProtKB/Swiss-Prot: APOC1_HUMAN, P02654Function: Appears to modulate the interaction of APOE with beta-migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related proteinGene Wiki entry for APOC1 |
Genomic Location for APOC1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the APOC1 gene 
Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.2APOC1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P050109:
(about GC identifiers)
Start:
|
50,109,419 bp from pter |
End:
|
50,114,446 bp from pter |
Size:
|
5,028 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011109.15
| Proteins for APOC1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: APOC1_HUMAN, P02654 (See
protein sequence)Recommended Name: Apolipoprotein C-I precursor Size: 83 amino acids; 9332 Da
Subcellular location: Secreted
Miscellaneous: Apo-CI makes up about 10% of the protein of the VLDL (very low density lipoprotein) and 2% of that of HDL (high density lipoprotein)
PDB structures from and Proteopedia :1ALE (3D)
 1ALF (3D)
 1IOJ (3D)
 1OPP (3D)
 
Secondary accessions: Q6IB97REFSEQ proteins: NP_001636.1
ENSEMBL proteins: ENSP00000252491
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for APOC1: Assays for APOC1: | Protein
Domains/ Families for APOC1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P02654
ProtoNet protein and cluster: P02654 1 Blocks protein family: IPB006781 Apolipoprotein C-I
UniProtKB/Swiss-Prot: APOC1_HUMAN, P02654Similarity: Belongs to the apolipoprotein C1 family | Gene Function for APOC1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001645
Applied Biosystems Silencer® siRNAs for APOC1
Sigma-Aldrich siRNA for APOC1  Sigma-Aldrich shRNA for APOC1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001645                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001645                                  untagged cDNA clone in CMV expression vector: NM_001645 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001645
UniProtKB/Swiss-Prot: APOC1_HUMAN, P02654Function: Appears to modulate the interaction of APOE with beta-migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related proteinGenatlas biochemistry entry for APOC1:apolipoprotein C-I,component of chylomicrons and VLDL2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Apoc1):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for APOC1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for APOC1 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for APOC1 
5/13 Interacting proteins for APOC1 (ENSP000002524913) via UniProtKB, MINT, and/or STRING (see all 13
)About this table
5/15 Gene Ontology (GO) biological process terms (links to tree view) (see all 15
): About this table
|
Drugs & Compounds for APOC1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for APOC1 7 Novoseek chemical compound relationships for APOC1 gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cholesterol |
57.98 |
42 |
15694932 (4), 8375418 (3), 17320883 (3), 15514255 (2) (see all 20) |
| dimyristoylphosphatidylcholine |
57.10 |
12 |
16042399 (3), 12705839 (1), 17341095 (1) |
| lipid |
45.08 |
31 |
17320883 (4), 11580293 (3), 11358499 (2), 9421476 (2) (see all 16) |
| tmao |
42.39 |
4 |
10548051 (3) |
| phospholipid |
33.08 |
11 |
11358499 (4), 17341095 (1), 17967413 (1), 11162594 (1) |
| fatty acid |
12.01 |
9 |
11723061 (3), 14523051 (2), 18307821 (1), 11357474 (1) (see all 5) |
| glucose |
0.00 |
10 |
11357474 (6), 11723061 (2) |
About this table
|
Transcripts for APOC1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001645
Sigma-Aldrich siRNA for APOC1  Sigma-Aldrich shRNA for APOC1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001645 REFSEQ mRNAs for APOC1 gene: NM_001645.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001645               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001645                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001645                                  untagged cDNA clone in CMV expression vector: NM_001645  Additional cDNA sequence: AF308154.1 AF308155.1 AJ249921.1 AK225971.1 AK312036.1 BC009698.2 BC055093.1 BT007142.1 CR456907.1 EF553526.1 M27359.1 X00570.1 17 DOTS entries: DT.454554 DT.100785802 DT.121427017 DT.100785800 DT.100785801 DT.95235208 DT.121426950 DT.92356500 DT.121427024 DT.100645505 DT.121426995 DT.121427070 DT.121427071 DT.95358902 DT.92457784 DT.92457788 DT.98083249 24/1484 AceView cDNA sequences (see all 1484
):BI489062 BQ029789 AI885116 AI363383 AI432333 AI096418 BM763973 BI521108 AI089911 CA437408 AI497936 BE463600 BG707355 CB054967 AI423535 BG762924 AI142531 AI767735 AI095143 BE044228 CA309520 AI359572 BG708414 AI796958
highest scoring ESTs for APOC1:AV703281 AV685966 BU927937 T71094 AV657156 BP304448 C01076 H57858 R29617 AA300375 Unigene Cluster for APOC1: Apolipoprotein C-I Hs.110675 [show with all ESTs]Unigene Representative Sequence: AJ249921
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for APOC1
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | |
| SP1: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for APOC1
1 Ensembl transcript including schematic representation: ENST00000252491
|
Expression for APOC1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| APOC1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for APOC1
1 / 2 / 3 6 probe-sets matching APOC1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGGCCCCAGG
SOURCE GeneReport for Unigene cluster: Hs.110675
Expression variation in blood from EXPOLDB for APOC1 UniProtKB/Swiss-Prot: APOC1_HUMAN, P02654Tissue specificity: Synthesized mainly in liver and to a minor degree in intestine. Secreted in plasma |
Orthologs for APOC1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for APOC1 gene from 4 species
About this table Species with no ortholog for APOC1
ENSEMBL Gene Tree for APOC1 | Paralogs for APOC1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for APOC1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| -- |
Disorders & Mutations for APOC1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 107710
10/17 Novoseek disease relationships for APOC1 gene (see all 17
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| combined hyperlipidemia |
54.52 |
2 |
15576844 (1) |
| skin abnormalities |
53.63 |
1 |
14523051 (1) |
| hypertriglyceridemia |
53.48 |
5 |
16478678 (2), 16537968 (1), 12454276 (1) |
| hyperlipidemia |
39.74 |
4 |
9421476 (1), 17320883 (1), 16537968 (1) |
| atherosclerosis |
38.33 |
13 |
17320883 (5), 12231568 (3), 15808756 (1), 18823887 (1) |
| alzheimers disease |
34.89 |
11 |
11825674 (2), 14705977 (1), 11702052 (1), 18160739 (1) (see all 6) |
| coronary heart disease |
25.06 |
1 |
2109805 (1) |
| memory impairment |
15.66 |
3 |
11714102 (2), 12736801 (1) |
| coronary artery disease |
6.22 |
4 |
12231568 (2), 10645915 (1) |
| cardiovascular diseases |
4.74 |
1 |
14746139 (1) |
About this table
Human Gene Mutation Database: APOC1 Genetic Association Database: APOC1 Human Genome Epidemiology Navigator: APOC1 (28 documents)
|
Medical News for APOC1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for APOC1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/188 PubMed articles for APOC1 gene (see all 188
):- Exact localization of the familial dysbetalipoproteinemia associated HpaI restriction site in the promoter region of the APOC1 gene. (PubMed id 2897845)3, 4, 6 Smit M.V.D.... Frants R.R. (1988)
- Genetic association of an apolipoprotein C-I (APOC1) gene polymorphism with late-onset Alzheimer's disease. (PubMed id 11825674)1, 3, 6 Ki C.S....Kim J.W. (2002)
- Plasma concentration and lipoprotein distribution of ApoC-I is dependent on ApoE genotype rather than the Hpa I ApoC-I promoter polymorphism. (PubMed id 12860251)1, 3, 6 Cohn J.S....Bernier L. (2003)
- [Antagonistic effect of the insertion/deletion (HpaI) polymorphism in the regulatory part of the gene for apolipoprotein CI in children with high and low levels of cholesterol] (PubMed id 15077570)1, 3, 6 Hubacek J.A....Poledne R. (2004)
- APOE and APOC1 promoter polymorphisms and the risk of Alzheimer disease in African American and Caribbean Hispanic individuals. (PubMed id 15364690)1, 3, 6 Tycko B....Mayeux R. (2004)
- Apolipoprotein E and apolipoprotein CI polymorphisms in the Czech population: almost complete linkage disequilibrium of the less frequent alleles of both polymorphisms. (PubMed id 12678662)1, 3, 6 Hubacek J.A....Poledne R. (2003)
- The common insertional polymorphism in the APOC1 promoter is associated with serum apolipoprotein C-I levels in Hispanic children. (PubMed id 15777558)1, 3, 6 Shachter N.S....Shea S. (2005)
- Apolipoproteins E and C1 and brain morphology in memory impaired elders. (PubMed id 12736801)1, 3, 6 Serra-Grabulosa J.M....Bartres-Faz D. (2003)
- Potential genetic markers of sporadic Alzheimer's dementia. (PubMed id 11702052)1, 3, 6 Retz W....Rosler M. (2001)
- Conformational studies of the N-terminal lipid-associating domain of human apolipoprotein C-I by CD and 1H NMR spectroscopy. (PubMed id 9300485)1, 3, 4 Rozek A.... Cushley R.J. (1997)
|
Search for APOC1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing APOC1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing APOC1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing APOC1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| Wikipedia | http://en.wikipedia.org/wiki/Apolipoprotein_C1 |
|
| | | About This Section
| --
| Services for APOC1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for APOC1:

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