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APOC1 Gene

protein-coding   GIFtS: 61
GCID: GC19P045417

Apolipoprotein C-I

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4.2

Aliases
Apolipoprotein C-I1 2
Apolipoprotein C12 3
apo-CIB2
apoC-IB2
Apolipoprotein C-I Variant I2

External Ids:    HGNC: 6071   Entrez Gene: 3412   Ensembl: ENSG000001302087   OMIM: 1077105   UniProtKB: P026543   
ORGUL members:    fRNAdb10:FR310306 FR053990 FR238908 FR253442      
H-InvDB12:HIT000076908 HIT000076907    
NCBI13:AF308155 AF308154    
NONCODE14:n333099 n333098    
RNAdb15:HIV2749 RNZ17502 RNZ17501 HIV2748    

Export aliases for APOC1 gene to outside databases

Previous GC identifers: GC19P046062 GC19P045808 GC19P050093 GC19P050109 GC19P041848


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for APOC1 Gene:
The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in
the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is
located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19,
where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found
for this gene, but the biological validity of some variants has not been determined. (provided by RefSeq, Jul
2008)

GeneCards Summary for APOC1 Gene:
APOC1 (apolipoprotein C-I) is a protein-coding gene. Diseases associated with APOC1 include memory impairment, and primary progressive aphasia. GO annotations related to this gene include phospholipase inhibitor activity and fatty acid binding.

UniProtKB/Swiss-Prot: APOC1_HUMAN, P02654
Function: Appears to modulate the interaction of APOE with beta-migrating VLDL and inhibit binding of beta-VLDL to
the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification

Gene Wiki entry for APOC1 (Apolipoprotein C1) Gene

fRNAdb sequence ontologies for APOC1 - the ORGUL cluster for this gene includes several descriptions:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.
nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for APOC1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the APOC1 gene promoter:
         AhR   c-Fos   AP-1   Sp1   Arnt   PPAR-gamma1   c-Jun   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAPOC1 promoter sequence
   Search Chromatin IP Primers for APOC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat APOC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.2

APOC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOC1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P045417:  view genomic region     (about GC identifiers)

Start:
45,417,504 bp from pter      End:
45,422,606 bp from pter
Size:
5,103 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: APOC1_HUMAN, P02654 (See protein sequence)
Recommended Name: Apolipoprotein C-I precursor  
Size: 83 amino acids; 9332 Da
Miscellaneous: Apolipoprotein C-I is present in acidic (APOC1A) and basic (APOC1B) forms in P.paniscus, P.abelii
and P.troglodytes and perhaps also in baboons and macaques. In human, the acidic form has become a pseudogene.
Apo-CI makes up about 10% of the protein of the VLDL (very low density lipoprotein) and 2% of that of HDL (high
density lipoprotein)
4 PDB 3D structures from and Proteopedia for APOC1:
1ALE (3D)        1ALF (3D)        1IOJ (3D)        1OPP (3D)    
Secondary accessions: B2R526 Q6IB97

Explore the universe of human proteins at neXtProt for APOC1: NX_P02654

Explore proteomics data for APOC1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See APOC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001636.1  
    ENSEMBL proteins: 
     ENSP00000465356   ENSP00000468029   ENSP00000468276   ENSP00000467368   ENSP00000467504  
     ENSP00000465710   ENSP00000465190   ENSP00000466146   ENSP00000466227   ENSP00000252491  

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    Cloud-Clone Corp. CLIAs for APOC1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    APOLIPO: Apolipoproteins

    1 InterPro protein domain:
     IPR006781 ApoC-I

    Graphical View of Domain Structure for InterPro Entry P02654

    ProtoNet protein and cluster: P02654

    1 Blocks protein domain: IPB006781 Apolipoprotein C-I

    UniProtKB/Swiss-Prot: APOC1_HUMAN, P02654
    Similarity: Belongs to the apolipoprotein C1 family


    APOC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: APOC1_HUMAN, P02654
    Function: Appears to modulate the interaction of APOE with beta-migrating VLDL and inhibit binding of beta-VLDL to
    the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification

         Genatlas biochemistry entry for APOC1:
    apolipoprotein C-I,component of chylomicrons and VLDL

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004859phospholipase inhibitor activity IDA2302419
    GO:0005504fatty acid binding IDA17339654
    GO:0031210phosphatidylcholine binding TAS2302419
    GO:0055102lipase inhibitor activity IDA15576844
    GO:0060228phosphatidylcholine-sterol O-acyltransferase activator activity TAS18992221
         
    APOC1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for APOC1:
     Decreased nuclei size in G2M  Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Apoc1):
     homeostasis/metabolism  liver/biliary system 

    APOC1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for APOC1: Apoc1tm2Lmh Apoc1tm1Lmh

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for APOC1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for APOC1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for APOC1

    miRNA
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    miRTarBase miRNAs that target APOC1:
    hsa-mir-335-5p (MIRT018338)

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    GenScript: all cDNA clones in your preferred vector: APOC1 (NM_001645)
    Sino Biological Human cDNA Clone for APOC1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat APOC1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    APOC1_HUMAN, P02654: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum4

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005783endoplasmic reticulum IDA--
    GO:0034361very-low-density lipoprotein particle IDA15576844
    GO:0034364high-density lipoprotein particle IDA15576844
    GO:0042627chylomicron TAS18992221

    APOC1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for APOC1 About    
    See pathways by source

    SuperPathContained pathways About
    1Statin Pathway
    Statin Pathway0.73
    Statin Pathway, Pharmacodynamics0.73


    1 BioSystems Pathway for APOC1
        Statin Pathway


    1 PharmGKB Pathway for APOC1
        Statin Pathway, Pharmacodynamics

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for APOC1
    Interactions:

        GeneGlobe Interaction Network for APOC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for APOC1 (P026542, 3 ENSP000002524914) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HMP19Q9Y3282, 3, ENSP000003077224MINT-8249025 I2D: score=2 STRING: ENSP00000307722
    APOA1P026473, ENSP000002368504I2D: score=2 STRING: ENSP00000236850
    APOA2P026523, ENSP000003569694I2D: score=1 STRING: ENSP00000356969
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    IGHA1P018763, ENSP000003749894I2D: score=1 STRING: ENSP00000374989
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process TAS2897845
    GO:0006641triglyceride metabolic process IEA--
    GO:0008203cholesterol metabolic process IEA--
    GO:0010873positive regulation of cholesterol esterification TAS18992221
    GO:0010900negative regulation of phosphatidylcholine catabolic process IDA2302419

    APOC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for APOC1

    Selected Novoseek inferred chemical compound relationships for APOC1 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dimyristoylphosphatidylcholine 59.6 13 16042399 (3), 12705839 (1), 17341095 (1), 19927327 (1)
    cholesterol 58.8 48 15694932 (4), 8375418 (3), 17320883 (3), 15514255 (2) (see all 22)
    lipid 47 33 17320883 (4), 11580293 (3), 11358499 (2), 9421476 (2) (see all 18)
    tmao 39.8 4 10548051 (3)
    phospholipid 36.7 16 11358499 (4), 18984910 (2), 17341095 (1), 17967413 (1) (see all 6)
    sodium dodecylsulfate 24 1 9923695 (1)
    rosiglitazone 17.7 1 14523051 (1)
    fatty acid 8.77 9 11723061 (3), 14523051 (2), 18307821 (1), 11357474 (1) (see all 5)
    glucose 0 11 11357474 (6), 11723061 (2), 19368908 (1)
    alanine 0 2 1379790 (1)

    2 PharmGKB related drug/compound annotations for APOC1 gene    About this table
    Drug/compound PharmGKB Annotation
    Antivirals for treatment of HIV infections, combinationsCA  
    ritonavirCA  



    APOC1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    4 fRNAdb Secondary structures:


    REFSEQ mRNAs for APOC1 gene: 
    NM_001645.3  

    Unigene Cluster for APOC1:

    Apolipoprotein C-I
    Hs.110675  [show with all ESTs]
    Unigene Representative Sequence: AJ249921
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000588750 ENST00000588802 ENST00000592535 ENST00000592885 ENST00000589781
    ENST00000589078 ENST00000590334 ENST00000586638 ENST00000592176 ENST00000252491(uc002pac.1 uc002pad.1 uc002pae.1 uc002paf.1)


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      QuantiFast Probe-based Assays in human, mouse, rat APOC1

    Additional mRNA sequence: 

    AJ249921.1 AK225971.1 AK312036.1 BC009698.2 BC055093.1 BT007142.1 CR456907.1 M27359.1 
    X00570.1 

    16 DOTS entries:

    DT.454554  DT.100785802  DT.121427017  DT.100785800  DT.100785801  DT.121426950  DT.92356500  DT.121427024 
    DT.95235208  DT.121426995  DT.121427070  DT.121427071  DT.95358902  DT.92457784  DT.98083249  DT.100645505 

    Selected AceView cDNA sequences (see all 1484):

    AI151046 BM708983 AI199595 BF934885 AI423768 BM662195 AI819172 AI017445 
    AA972388 AW237715 AI094884 BI521718 AW026683 AI244513 AI318415 BX109900 
    AI371798 BE857547 AI459713 AI934504 AI796958 BQ575791 BI521647 AI311319 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for APOC1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
    SP1:              -                                                   
    SP2:              -     -                                             
    SP3:                                                                  
    SP4:                                                                  


    ECgene alternative splicing isoforms for APOC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    APOC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCCCCAGG
    APOC1 Expression
    About this image


    APOC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Brain (Nervous System)
             Cerebral Cortex
    APOC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    APOC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.110675

    UniProtKB/Swiss-Prot: APOC1_HUMAN, P02654
    Tissue specificity: Synthesized mainly in liver and to a minor degree in intestine. Secreted in plasma

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for APOC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for APOC1 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Apoc15 apolipoprotein C-I   --   7 (9.94 cM) 19689484 


    ENSEMBL Gene Tree for APOC1 (if available)
    TreeFam Gene Tree for APOC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for APOC1 gene

    APOC1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for APOC1
    PGOHUM00000234721


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    5 SNPs for APOC1    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3761270051,2
    C--45419394(+) ATCTC-/A/AA  
      AAAAAA
    AAAAA
    1 -- int10--------
    rs72562001,2
    C,F,A--45606158(+) CAGGCG/TTGAGC 1 -- us2k17Minor allele frequency- T:0.11NA WA EA 250
    rs1140555331,2
    C,F--45606173(+) GCAACC/TAGCCA 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs51121,2,4
    ----see VAR_0141832 mis40--------
    rs1423722751,2,4
    ----see VAR_0290112 mis40--------

    HapMap Linkage Disequilibrium report for APOC1 (45417504 - 45422606 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for APOC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509747CNV Insertion20534489
    nsv912134CNV Loss21882294
    nsv138296CNV Loss16902084
    nsv912133CNV Loss21882294
    dgv3948n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): APOC1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing APOC1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 107710OMIM information: 108725 120050 125630 145250 145981 181800 600209 601846 602477 605364 606674 607508 609306    
    Selected diseases for APOC1 (see all 37):    
    About MalaCards
    memory impairment    primary progressive aphasia    coronary heart disease    hypertriglyceridemia
    coronary artery disease    aphasia    gigantism    acne
    papillary thyroid carcinoma    liposarcoma    frontotemporal dementia    hepatitis c virus
    dementia    atopic dermatitis    insulin resistance    atherosclerosis
    polycystic ovary syndrome    alzheimer's disease    thyroid cancer    stomach cancer


    APOC1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for APOC1 gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    combined hyperlipidemia 52.7 2 15576844 (1)
    skin abnormalities 51.4 1 14523051 (1)
    hypertriglyceridemia 51.2 5 16478678 (2), 16537968 (1), 12454276 (1)
    atherosclerosis 42.3 13 17320883 (5), 12231568 (3), 15808756 (1), 18823887 (1)
    alzheimers disease 37.6 11 11825674 (2), 14705977 (1), 11702052 (1), 18160739 (1) (see all 6)
    hyperlipidemia 37.1 4 9421476 (1), 17320883 (1), 16537968 (1)
    coronary heart disease 22.3 1 2109805 (1)
    cardiovascular diseases 18.5 3 20094647 (1), 19252179 (1), 14746139 (1)
    memory impairment 12.3 3 11714102 (2), 12736801 (1)
    coronary artery disease 9.28 5 12231568 (2), 10645915 (1), 19252179 (1)

    Genetic Association Database (GAD): APOC1
    Human Genome Epidemiology (HuGE) Navigator: APOC1 (54 documents)

    Export disorders for APOC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for APOC1 gene, integrated from 10 sources (see all 259):
    (articles sorted by number of sources associating them with APOC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Exact localization of the familial dysbetalipoproteinemia associated HpaI restriction site in the promoter region of the APOC1 gene. (PubMed id 2897845)1, 2, 4 Smit M.V.D.... Frants R.R. (Biochem. Biophys. Res. Commun. 1988)
    2. Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification. (PubMed id 17339654)1, 2, 9 Westerterp M.... Rensen P.C. (J. Lipid Res. 2007)
    3. Genetic association of an apolipoprotein C-I (APOC1) gene polymorphism with late-onset Alzheimer's disease. (PubMed id 11825674)1, 4, 9 Ki C.S....Kim J.W. (Neurosci. Lett. 2002)
    4. Plasma concentration and lipoprotein distribution of ApoC-I is dependent on ApoE genotype rather than the Hpa I ApoC-I promoter polymorphism. (PubMed id 12860251)1, 4, 9 Cohn J.S....Bernier L. (Atherosclerosis 2003)
    5. ApoE and ApoC-I polymorphisms: association of genotype with cardiovascular disease phenotype in African Americans. (PubMed id 19252179)1, 4, 9 Anuurad E....Berglund L. (J. Lipid Res. 2009)
    6. [Antagonistic effect of the insertion/deletion (HpaI) polymorphism in the regulatory part of the gene for apolipoprotein CI in children with high and low levels of cholesterol]. (PubMed id 15077570)1, 4, 9 HubA!cek J.A....Poledne R. (Cas. Lek. Cesk. 2004)
    7. APOE and APOC1 promoter polymorphisms and the risk of Alzheimer disease in African American and Caribbean Hispanic individuals. (PubMed id 15364690)1, 4, 9 Tycko B....Mayeux R. (Arch. Neurol. 2004)
    8. Apolipoprotein E and apolipoprotein CI polymorphisms in the Czech population: almost complete linkage disequilibrium of the less frequent alleles of both polymorphisms. (PubMed id 12678662)1, 4, 9 HubA!cek J.A....Poledne R. (Physiol Res 2003)
    9. The common insertional polymorphism in the APOC1 promoter is associated with serum apolipoprotein C-I levels in Hispanic children. (PubMed id 15777558)1, 4, 9 Shachter N.S....Shea S. (Atherosclerosis 2005)
    10. Apolipoproteins E and C1 and brain morphology in memory impaired elders. (PubMed id 12736801)1, 4, 9 Serra-Grabulosa J.M....BartrAcs-Faz D. (Neurogenetics 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 341 HGNC: 607 AceView: APOEandAPOC1 Ensembl:ENSG00000130208 euGenes: HUgn341
    ECgene: APOC1 H-InvDB: APOC1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for APOC1 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Apolipoprotein_C1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for APOC1 gene:
    Search GeneIP for patents involving APOC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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