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Aliases for APOC1 Gene

Aliases for APOC1 Gene

  • Apolipoprotein C-I 2 3
  • Apolipoprotein C1 3 4
  • Apo-CI 3 4
  • ApoC-I 3 4
  • Apolipoprotein C-I Variant I 3
  • Apo-CIB 3
  • ApoC-IB 3

External Ids for APOC1 Gene

Summaries for APOC1 Gene

Entrez Gene Summary for APOC1 Gene

  • The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOC1 Gene

APOC1 (Apolipoprotein C-I) is a Protein Coding gene. Diseases associated with APOC1 include stomach cancer and aphasia. Among its related pathways are Statin Pathway and Statin Pathway. GO annotations related to this gene include fatty acid binding and phospholipase inhibitor activity.

UniProtKB/Swiss-Prot for APOC1 Gene

  • Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.

Gene Wiki entry for APOC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOC1 Gene

Genomics for APOC1 Gene

Genomic Location for APOC1 Gene

Start:
44,914,247 bp from pter
End:
44,919,349 bp from pter
Size:
5,103 bases
Orientation:
Plus strand

Genomic View for APOC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APOC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOC1 Gene

Regulatory Elements for APOC1 Gene

Proteins for APOC1 Gene

  • Protein details for APOC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02654-APOC1_HUMAN
    Recommended name:
    Apolipoprotein C-I
    Protein Accession:
    P02654
    Secondary Accessions:
    • B2R526
    • Q6IB97

    Protein attributes for APOC1 Gene

    Size:
    83 amino acids
    Molecular mass:
    9332 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Apolipoprotein C-I is present in acidic (APOC1A) and basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and perhaps also in baboons and macaques. The two genes for ApoC-I arose through a duplication process that occurred after the divergence of New World monkeys from the human lineage. In human, the acidic form has become a pseudogene sometime between the divergence of bonobos and chimpanzees from the human lineage and the appearance of the Denisovans. Pseudogenization resulted when the codon for the penultimate amino acid in the signal sequence was changed to a stop codon.

    Three dimensional structures from OCA and Proteopedia for APOC1 Gene

neXtProt entry for APOC1 Gene

Proteomics data for APOC1 Gene at MOPED

Post-translational modifications for APOC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for APOC1 Gene

Domains for APOC1 Gene

Gene Families for APOC1 Gene

HGNC:

Protein Domains for APOC1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

APOC1_HUMAN
Family:
  • Belongs to the apolipoprotein C1 family.:
    • P02654
genes like me logo Genes that share domains with APOC1: view

Function for APOC1 Gene

Molecular function for APOC1 Gene

GENATLAS Biochemistry: apolipoprotein C-I,component of chylomicrons and VLDL
UniProtKB/Swiss-Prot Function: Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.

Gene Ontology (GO) - Molecular Function for APOC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004859 phospholipase inhibitor activity IDA 2302419
GO:0005504 fatty acid binding IDA 17339654
GO:0031210 phosphatidylcholine binding TAS 2302419
GO:0055102 lipase inhibitor activity IDA 15576844
GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity TAS 18992221
genes like me logo Genes that share ontologies with APOC1: view

Phenotypes for APOC1 Gene

genes like me logo Genes that share phenotypes with APOC1: view

Animal Models for APOC1 Gene

MGI Knock Outs for APOC1:

miRNA for APOC1 Gene

miRTarBase miRNAs that target APOC1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for APOC1 Gene

Localization for APOC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOC1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOC1 Gene COMPARTMENTS Subcellular localization image for APOC1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4

Gene Ontology (GO) - Cellular Components for APOC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005783 endoplasmic reticulum IDA --
GO:0034361 very-low-density lipoprotein particle IDA 15576844
GO:0034364 high-density lipoprotein particle IDA 15576844
GO:0042627 chylomicron TAS 18992221
genes like me logo Genes that share ontologies with APOC1: view

Pathways for APOC1 Gene

SuperPathways for APOC1 Gene

Superpath Contained pathways
1 Statin Pathway
genes like me logo Genes that share pathways with APOC1: view

Pathways by source for APOC1 Gene

1 BioSystems pathway for APOC1 Gene
1 PharmGKB pathway for APOC1 Gene

Interacting Proteins for APOC1 Gene

Gene Ontology (GO) - Biological Process for APOC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 2897845
GO:0006641 triglyceride metabolic process IEA --
GO:0008203 cholesterol metabolic process IEA --
GO:0010873 positive regulation of cholesterol esterification TAS 18992221
GO:0010900 negative regulation of phosphatidylcholine catabolic process IDA 2302419
genes like me logo Genes that share ontologies with APOC1: view

Compounds for APOC1 Gene

(12) Novoseek inferred chemical compound relationships for APOC1 Gene

Compound -log(P) Hits PubMed IDs
dimyristoylphosphatidylcholine 59.6 6
cholesterol 58.8 33
lipid 47 25
tmao 39.8 3
phospholipid 36.7 10

(2) PharmGKB related drug/compound annotations for APOC1 Gene

genes like me logo Genes that share compounds with APOC1: view

Transcripts for APOC1 Gene

Unigene Clusters for APOC1 Gene

Apolipoprotein C-I:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APOC1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2: - -
SP3:
SP4:

Relevant External Links for APOC1 Gene

GeneLoc Exon Structure for
APOC1
ECgene alternative splicing isoforms for
APOC1

Expression for APOC1 Gene

mRNA expression in normal human tissues for APOC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for APOC1 Gene

This gene is overexpressed in Liver (37.7) and Adrenal Gland (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for APOC1 Gene

SOURCE GeneReport for Unigene cluster for APOC1 Gene Hs.110675

mRNA Expression by UniProt/SwissProt for APOC1 Gene

P02654-APOC1_HUMAN
Tissue specificity: Synthesized mainly in liver and to a minor degree in intestine. Also found in the lung and spleen.
genes like me logo Genes that share expressions with APOC1: view

Orthologs for APOC1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for APOC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APOC1 37
  • 99 (a)
OneToOne
APOC1A 36
  • 90.36 (n)
  • 77.11 (a)
dog
(Canis familiaris)
Mammalia APOC1 37
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Apoc1 16
Apoc1 37
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia APOC1 37
  • 39 (a)
OneToOne
Species with no ortholog for APOC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for APOC1 Gene

ENSEMBL:
Gene Tree for APOC1 (if available)
TreeFam:
Gene Tree for APOC1 (if available)

Paralogs for APOC1 Gene

Pseudogenes.org Pseudogenes for APOC1 Gene

genes like me logo Genes that share paralogs with APOC1: view

No data available for Paralogs for APOC1 Gene

Variants for APOC1 Gene

Sequence variations from dbSNP and Humsavar for APOC1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs5111 -- 44,914,909(+) CTGTC(A/G)CTCCC synonymous-codon, reference
rs5114 -- 44,915,189(+) ATTGG(C/T)TGTCC intron-variant
rs5115 -- 44,915,496(+) cagta(G/T)agaca intron-variant
rs5116 -- 44,915,520(+) gtctc(A/G)atctc intron-variant
rs5117 -- 44,915,533(+) GACTT(C/T)GTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for APOC1 Gene

Variant ID Type Subtype PubMed ID
dgv3948n71 CNV Loss 21882294
nsv509747 CNV Insertion 20534489
nsv912133 CNV Loss 21882294
nsv912134 CNV Loss 21882294
nsv138296 CNV Loss 16902084

Relevant External Links for APOC1 Gene

HapMap Linkage Disequilibrium report
APOC1
Human Gene Mutation Database (HGMD)
APOC1

Disorders for APOC1 Gene

(17) Novoseek inferred disease relationships for APOC1 Gene

Disease -log(P) Hits PubMed IDs
combined hyperlipidemia 52.7 1
skin abnormalities 51.4 1
hypertriglyceridemia 51.2 4
atherosclerosis 42.3 10
alzheimers disease 37.6 7

Relevant External Links for APOC1

Genetic Association Database (GAD)
APOC1
Human Genome Epidemiology (HuGE) Navigator
APOC1
genes like me logo Genes that share disorders with APOC1: view

No data available for UniProtKB/Swiss-Prot for APOC1 Gene

Publications for APOC1 Gene

  1. Conformational studies of the N-terminal lipid-associating domain of human apolipoprotein C-I by CD and 1H NMR spectroscopy. (PMID: 9300485) Rozek A. … Cushley R.J. (Protein Sci. 1997) 3 4 23
  2. Potential genetic markers of sporadic Alzheimer's dementia. (PMID: 11702052) Retz W. … RAPsler M. (Psychiatr. Genet. 2001) 3 23 49
  3. Genetic association of an apolipoprotein C-I (APOC1) gene polymorphism with late-onset Alzheimer's disease. (PMID: 11825674) Ki C.S. … Kim J.W. (Neurosci. Lett. 2002) 3 23 49
  4. Apolipoprotein molecular variation in Moroccan Berbers: pentanucleotide (TTTTA)n repeat in the LPA gene and APOE-C1-C2 gene cluster. (PMID: 12220441) Harich N. … Moral P. (Clin. Genet. 2002) 3 23 49
  5. An improved RSP method to detect HpaI polymorphism in the apolipoprotein C-1 gene promoter. (PMID: 12429068) Gao L. … Ye S.Q. (BMC Med. Genet. 2002) 3 23 49

Products for APOC1 Gene

Sources for APOC1 Gene

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