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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

APOC1 Gene

protein-coding GIFtS: 57
GCID: GC19P045417

apolipoprotein C-I

Explore 35 diseases affiliated with
APOC1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Apolipoprotein C-I¹ ²		APOC1B³
Apolipoprotein C1² ³		Apo-CIB³
Apo-CIB³		ApoC-IB³
ApoC-IB³

External Ids:	HGNC: 607¹	Entrez Gene: 341²	Ensembl: ENSG00000130208⁷	OMIM: 107710⁵	UniProtKB: P02654³

Export aliases for APOC1 gene to outside databases

Previous GC identifers: GC19P046062 GC19P045808 GC19P050093 GC19P050109 GC19P041848

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for APOC1:

The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the

liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb

downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides

within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the

biological validity of some variants has not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: APOC1_HUMAN, P02654

Function: Appears to modulate the interaction of APOE with beta-migrating VLDL and inhibit binding of beta-VLDL to the

LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification

Gene Wiki entry for APOC1 (Apolipoprotein C1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the APOC1 gene promoter:
AhR c-Fos AP-1 Sp1 Arnt PPAR-gamma1 c-Jun PPAR-gamma2 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: APOC1 promoter sequence

Search SABiosciences Chromatin IP Primers for APOC1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat APOC1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.2

APOC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
APOC1 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P045417: view genomic region (about GC identifiers)

Start:	45,417,504 bp from pter	End:	45,422,606 bp from pter
Size:	5,103 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: APOC1_HUMAN, P02654 (See protein sequence)

Recommended Name: Apolipoprotein C-I precursor

Size: 83 amino acids; 9332 Da

Subcellular location: Secreted

Miscellaneous: Apolipoprotein C-I is present in acidic (APOC1A) and basic (APOC1B) forms in P.paniscus, P.abelii and

P.troglodytes and perhaps also in baboons and macaques. In human, the acidic form has become a pseudogene. Apo-CI

makes up about 10% of the protein of the VLDL (very low density lipoprotein) and 2% of that of HDL (high density

lipoprotein)

4 PDB 3D structures from and Proteopedia for APOC1:

1ALE (3D)

1ALF (3D)

1IOJ (3D)

1OPP (3D)

Secondary accessions: Q6IB97

Explore the universe of human proteins at neXtProt for APOC1: NX_P02654

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P02654

APOC1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001636.1

ENSEMBL proteins:

ENSP00000465356 ENSP00000468029 ENSP00000468276 ENSP00000467368 ENSP00000467504

ENSP00000465710 ENSP00000465190 ENSP00000466146 ENSP00000466227 ENSP00000252491

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	Novus Biologicals APOC1 Proteins Novus Biologicals APOC1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for APOC1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IDA	--
GO:0034361	very-low-density lipoprotein particle	IDA	15576844
GO:0034364	high-density lipoprotein particle	IDA	15576844
GO:0042627	chylomicron	TAS	18992221

APOC1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for APOC1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

APOC1 for domains About GeneDecksing

1 InterPro domain/family:

IPR006781 ApoC-I

Graphical View of Domain Structure for InterPro Entry P02654

ProtoNet protein and cluster: P02654

1 Blocks protein family: IPB006781 Apolipoprotein C-I

UniProtKB/Swiss-Prot: APOC1_HUMAN, P02654

Similarity: Belongs to the apolipoprotein C1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: APOC1_HUMAN, P02654

Function: Appears to modulate the interaction of APOE with beta-migrating VLDL and inhibit binding of beta-VLDL to the

LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification

Genatlas biochemistry entry for APOC1:

apolipoprotein C-I,component of chylomicrons and VLDL

miRNA Products:		OriGene 3'-UTR Clone: APOC1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat APOC1
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		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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		GenScript: all cDNA clones in your preferred vector: APOC1 (NM_001645)
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		Search LifeMap BioReagents cell lines for APOC1

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for APOC1

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004859	phospholipase inhibitor activity	IDA	2302419
GO:0005504	fatty acid binding	IDA	17339654
GO:0031210	phosphatidylcholine binding	TAS	2302419
GO:0055102	lipase inhibitor activity	IDA	15576844
GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity	TAS	18992221

APOC1 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for APOC1:

Decreased nuclei size in G2M

Synthetic lethal with Ras

Animal Models:
Mouse knock-outs for APOC1: Apoc1^tm2Lmh Apoc1^tm1Lmh
2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Apoc1):

homeostasis/metabolism

liver/biliary system

APOC1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Statin Pathway, Pharmacodynamics

Statin Pathway, Pharmacodynamics

1.00

Statin Pathway

0.80

1 BioSystems Pathway for APOC1

Statin Pathway

1 PharmGKB Pathway for APOC1

Statin Pathway, Pharmacodynamics

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for APOC1

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/6 Interacting proteins for APOC1 (P02654^{2, 3} ENSP00000252491⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HMP19	Q9Y328²^,³, ENSP00000307722⁴	MINT-8249025 I2D: score=2 STRING: ENSP00000307722
APOA1	P02647³, ENSP00000236850⁴	I2D: score=2 STRING: ENSP00000236850
APOA2	P02652³, ENSP00000356969⁴	I2D: score=1 STRING: ENSP00000356969
ALB	P02768³, ENSP00000295897⁴	I2D: score=1 STRING: ENSP00000295897
IGHA1	P01876³, ENSP00000374989⁴	I2D: score=1 STRING: ENSP00000374989

About this table

Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	TAS	2897845
GO:0006641	triglyceride metabolic process	--	--
GO:0008203	cholesterol metabolic process	--	--
GO:0010873	positive regulation of cholesterol esterification	TAS	18992221
GO:0010900	negative regulation of phosphatidylcholine catabolic process	IDA	2302419

APOC1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

APOC1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for APOC1
10/12 Novoseek chemical compound relationships for APOC1 gene (see all 12) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dimyristoylphosphatidylcholine	59.6	13	16042399 (3), 12705839 (1), 17341095 (1), 19927327 (1)
cholesterol	58.8	48	15694932 (4), 8375418 (3), 17320883 (3), 15514255 (2) (see all 22)
lipid	47	33	17320883 (4), 11580293 (3), 11358499 (2), 9421476 (2) (see all 18)
tmao	39.8	4	10548051 (3)
phospholipid	36.7	16	11358499 (4), 18984910 (2), 17341095 (1), 17967413 (1) (see all 6)
sodium dodecylsulfate	24	1	9923695 (1)
rosiglitazone	17.7	1	14523051 (1)
fatty acid	8.77	9	11723061 (3), 14523051 (2), 18307821 (1), 11357474 (1) (see all 5)
glucose	0	11	11357474 (6), 11723061 (2), 19368908 (1)
alanine	0	2	1379790 (1)

2 PharmGKB related drug/compound annotations for APOC1 gene

Drug/compound	PharmGKB Annotation
"Antivirals for treatment of HIV infections, combinations"	CA
ritonavir	CA

About this table

Search CenterWatch for drugs/clinical trials and news about APOC1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for APOC1 gene:

NM_001645.3

Unigene Cluster for APOC1:

Apolipoprotein C-I

Hs.110675 [show with all ESTs]

Unigene Representative Sequence: AJ249921

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000588750 ENST00000588802 ENST00000592535 ENST00000592885 ENST00000589781

ENST00000589078 ENST00000590334 ENST00000586638 ENST00000592176 ENST00000252491(uc002pac.1 uc002pad.1 uc002pae.1 uc002paf.1)

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		GenScript: all cDNA clones in your preferred vector: APOC1 (NM_001645)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APOC1

Additional cDNA sequence:

AJ249921.1 AK225971.1 AK312036.1 BC009698.2 BC055093.1 BT007142.1 CR456907.1 M27359.1

X00570.1

16 DOTS entries:

DT.454554 DT.100785802 DT.121427017 DT.100785800 DT.100785801 DT.121426950 DT.92356500 DT.121427024

DT.95235208 DT.121426995 DT.121427070 DT.121427071 DT.95358902 DT.92457784 DT.98083249 DT.100645505

24/1484 AceView cDNA sequences (see all 1484):

AI421642 BG054906 BQ268170 BF340379 CB046794 AI356166 AI360161 AI198341

BU628900 AI418916 AI418196 AI493455 CD367385 AI027482 BQ651295 AI423643

AI242284 BE672007 AW008865 BF591506 AI355908 AI359206 N59187 NM_001645

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for APOC1 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8
SP1:					-
SP2:					-		-
SP3:
SP4:

ECgene alternative splicing isoforms for APOC1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

APOC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGCCCCAGG

About this image

APOC1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See APOC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for APOC1

SOURCE GeneReport for Unigene cluster: Hs.110675

UniProtKB/Swiss-Prot: APOC1_HUMAN, P02654

Tissue specificity: Synthesized mainly in liver and to a minor degree in intestine. Secreted in plasma

SABiosciences Custom PCR Arrays for APOC1

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat APOC1

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for APOC1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for APOC1 gene from 1/5 species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Apoc1^{1 , 5}	apolipoprotein C-I^{1, 5}	75(n)¹ 70(a)¹		7 (9.94 cM)⁵ 11812¹ NM_001110009.1¹ NP_001103479.1¹ 19689484⁵

ENSEMBL Gene Tree for APOC1 (if available)
TreeFam Gene Tree for APOC1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for APOC1 gene

APOC1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for APOC1
PGOHUM00000234721

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7256200^1,2	C,F,A,	--	45415935(+)	`CAGGCG/TTGAGC`	1	--	us2k¹		7		NA WA EA	250
rs114055533^1,2		--	45415950(+)	`GCAACC/TAGCCA`	1	--	us2k¹		1		WA	118
rs111354760^1,2	F	--	45416087(+)	`GTTATG/TCTATT`	1	--	us2k¹		2		CSA	4
rs72654437^1,2	C,F,	--	45416099(+)	`TTGTGG/AGGTCT`	1	--	us2k¹		1		NS	744
rs483082^1,2	C,F,A,	--	45416178(-)	`CCTGTA/CAGCCC`	1	--	us2k¹		11		NA NS WA EA	1222
rs188183830^1,2		--	45416197(+)	`GCTCTA/GAGCTG`	1	--	us2k¹		0	--	--	--	--
rs146404925^1,2		--	45416270(+)	`CCTACC/TGCCAG`	1	--	us2k¹		0	--	--	--	--
rs59325138^1,2	C,F,	--	45416291(+)	`GGTTGC/TGGGGG`	1	--	us2k¹		7		NS NA WA EA	1108
rs192803464^1,2		--	45416354(+)	`CCAGCA/TGCCAG`	1	--	us2k¹		0	--	--	--	--
rs72654440^1,2	F	--	45416462(+)	`GGGGCG/ATCAGA`	1	--	us2k¹		1		NS	742

HapMap Linkage Disequilibrium report for APOC1 (45417504 - 45422606 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for APOC1
1 CNV: 5956
Human Gene Mutation Database (HGMD): APOC1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing APOC1

DNA2.0 Custom Variant and Variant Library Synthesis for APOC1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

APOC1 for disorders           About GeneDecksing

OMIM gene information: 107710    OMIM disorders: --

20/35 diseases for APOC1 (see all 35):    About MalaCards

memory impairment coronary heart disease polycystic ovary syndrome insulin resistance

hyperlipidemia atopic dermatitis papillary thyroid carcinoma hypertriglyceridemia

hyperlipoproteinemia alzheimer's disease renal cell carcinoma thyroid carcinoma

gigantism liposarcoma acne multiple sclerosis

dermatitis hepatitis c dementia thyroiditis

10/17 Novoseek disease relationships for APOC1 gene (see all 17) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
combined hyperlipidemia	52.7	2	15576844 (1)
skin abnormalities	51.4	1	14523051 (1)
hypertriglyceridemia	51.2	5	16478678 (2), 16537968 (1), 12454276 (1)
atherosclerosis	42.3	13	17320883 (5), 12231568 (3), 15808756 (1), 18823887 (1)
alzheimers disease	37.6	11	11825674 (2), 14705977 (1), 11702052 (1), 18160739 (1) (see all 6)
hyperlipidemia	37.1	4	9421476 (1), 17320883 (1), 16537968 (1)
coronary heart disease	22.3	1	2109805 (1)
cardiovascular diseases	18.5	3	20094647 (1), 19252179 (1), 14746139 (1)
memory impairment	12.3	3	11714102 (2), 12736801 (1)
coronary artery disease	9.28	5	12231568 (2), 10645915 (1), 19252179 (1)

Genetic Association Database (GAD): APOC1
Human Genome Epidemiology (HuGE) Navigator: APOC1 (54 documents)

Export disorders for APOC1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for APOC1 gene, integrated from 9 sources (see all 243):
(articles sorted by number of sources associating them with APOC1)

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Exact localization of the familial dysbetalipoproteinemia associated HpaI restriction site in the promoter region of the APOC1 gene. (PubMed id 2897845)^{1, 2, 4} Smit M.V.D.... Frants R.R. (1988)
Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification. (PubMed id 17339654)^{1, 2, 9} Westerterp M....Rensen P.C. (2007)
Genetic association of an apolipoprotein C-I (APOC1) gene polymorphism with late-onset Alzheimer's disease. (PubMed id 11825674)^{1, 4, 9} Ki C.S....Kim J.W. (2002)
Plasma concentration and lipoprotein distribution of ApoC-I is dependent on ApoE genotype rather than the Hpa I ApoC-I promoter polymorphism. (PubMed id 12860251)^{1, 4, 9} Cohn J.S....Bernier L. (2003)
[Antagonistic effect of the insertion/deletion (HpaI) polymorphism in the regulatory part of the gene for apolipoprotein CI in children with high and low levels of cholesterol] (PubMed id 15077570)^{1, 4, 9} Hubacek J.A....Poledne R. (2004)
APOE and APOC1 promoter polymorphisms and the risk of Alzheimer disease in African American and Caribbean Hispanic individuals. (PubMed id 15364690)^{1, 4, 9} Tycko B....Mayeux R. (2004)
Apolipoprotein E and apolipoprotein CI polymorphisms in the Czech population: almost complete linkage disequilibrium of the less frequent alleles of both polymorphisms. (PubMed id 12678662)^{1, 4, 9} Hubacek J.A....Poledne R. (2003)
The common insertional polymorphism in the APOC1 promoter is associated with serum apolipoprotein C-I levels in Hispanic children. (PubMed id 15777558)^{1, 4, 9} Shachter N.S....Shea S. (2005)
Apolipoproteins E and C1 and brain morphology in memory impaired elders. (PubMed id 12736801)^{1, 4, 9} Serra-Grabulosa J.M....Bartres-Faz D. (2003)
Potential genetic markers of sporadic Alzheimer's dementia. (PubMed id 11702052)^{1, 4, 9} Retz W....Rosler M. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 341	HGNC: 607	AceView: APOEandAPOC1	Ensembl:ENSG00000130208	euGenes: HUgn341
ECgene: APOC1	H-InvDB: APOC1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for APOC1	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Apolipoprotein_C1

Intellectual Property for APOC1 gene
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Patent Information for APOC1 gene:
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