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Aliases for APOBR Gene

Aliases for APOBR Gene

  • Apolipoprotein B Receptor 2 3 5
  • Apolipoprotein B48 Receptor 2 3 4
  • Apolipoprotein B-100 Receptor 3 4
  • Apolipoprotein B100 Receptor 2 3
  • Apolipoprotein B-48 Receptor 3 4
  • ApoB-48R 3 4
  • APOB48R 3 4
  • APOB100R 3

External Ids for APOBR Gene

Previous GeneCards Identifiers for APOBR Gene

  • GC16P028506

Summaries for APOBR Gene

Entrez Gene Summary for APOBR Gene

  • Apolipoprotein B48 receptor is a macrophage receptor that binds to the apolipoprotein B48 of dietary triglyceride (TG)-rich lipoproteins. This receptor may provide essential lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells. If overwhelmed with elevated plasma triglyceride, the apolipoprotein B48 receptor may contribute to foam cell formation, endothelial dysfunction, and atherothrombogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for APOBR Gene

APOBR (Apolipoprotein B Receptor) is a Protein Coding gene. GO annotations related to this gene include very-low-density lipoprotein particle receptor activity.

UniProtKB/Swiss-Prot for APOBR Gene

  • Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOBR Gene

Genomics for APOBR Gene

Regulatory Elements for APOBR Gene

Promoters for APOBR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around APOBR on UCSC Golden Path with GeneCards custom track

Genomic Location for APOBR Gene

Chromosome:
16
Start:
28,494,649 bp from pter
End:
28,498,970 bp from pter
Size:
4,322 bases
Orientation:
Plus strand

Genomic View for APOBR Gene

Genes around APOBR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
APOBR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for APOBR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for APOBR Gene

Proteins for APOBR Gene

  • Protein details for APOBR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0VD83-APOBR_HUMAN
    Recommended name:
    Apolipoprotein B receptor
    Protein Accession:
    Q0VD83
    Secondary Accessions:
    • H3BU97
    • Q0VD81
    • Q8NC15
    • Q9NPJ9

    Protein attributes for APOBR Gene

    Size:
    1088 amino acids
    Molecular mass:
    114874 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for APOBR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for APOBR Gene

Proteomics data for APOBR Gene at MOPED

Post-translational modifications for APOBR Gene

  • There are 2 forms in macrophages, the membrane-binding proteins 200 kDa (MBP 200) and 235 kDa (MBP 235), that can be reduced into a single active ligand-binding species with intermediate mobility (MBP 200R).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for APOBR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for APOBR Gene

Domains & Families for APOBR Gene

Protein Domains for APOBR Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for APOBR Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with APOBR: view

No data available for Gene Families and UniProtKB/Swiss-Prot for APOBR Gene

Function for APOBR Gene

Molecular function for APOBR Gene

UniProtKB/Swiss-Prot Function:
Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages.
UniProtKB/Swiss-Prot Induction:
Suppressed significantly by PPARA and PPARG in THP-1 and blood-borne monocyte-macrophages. Decreased after pitavastatin treatment in peripheral blood macrophages and remnant lipoprotein (RLP)-induced foam cell formation.

Phenotypes for APOBR Gene

genes like me logo Genes that share phenotypes with APOBR: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for APOBR Gene

Localization for APOBR Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOBR Gene

Cell membrane; Peripheral membrane protein. Note=Binds monocyte-macrophage membrane. Thought to be anchored in the membrane through an interaction with an integral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOBR Gene COMPARTMENTS Subcellular localization image for APOBR gene
Compartment Confidence
extracellular 4
nucleus 3
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for APOBR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034362 low-density lipoprotein particle IEA --
genes like me logo Genes that share ontologies with APOBR: view

Pathways & Interactions for APOBR Gene

SuperPathways for APOBR Gene

No Data Available

Interacting Proteins for APOBR Gene

Gene Ontology (GO) - Biological Process for APOBR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IBA --
genes like me logo Genes that share ontologies with APOBR: view

No data available for Pathways by source and SIGNOR curated interactions for APOBR Gene

Drugs & Compounds for APOBR Gene

No Compound Related Data Available

Transcripts for APOBR Gene

mRNA/cDNA for APOBR Gene

Unigene Clusters for APOBR Gene

Apolipoprotein B receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APOBR Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c
SP1:
SP2: - -
SP3:

Relevant External Links for APOBR Gene

GeneLoc Exon Structure for
APOBR
ECgene alternative splicing isoforms for
APOBR

Expression for APOBR Gene

mRNA expression in normal human tissues for APOBR Gene

mRNA differential expression in normal tissues according to GTEx for APOBR Gene

This gene is overexpressed in Whole Blood (x32.8), Spleen (x4.6), and Colon - Transverse (x4.5).

Protein differential expression in normal tissues from HIPED for APOBR Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.2), Lavage (14.0), and Monocytes (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for APOBR Gene



SOURCE GeneReport for Unigene cluster for APOBR Gene Hs.200333

mRNA Expression by UniProt/SwissProt for APOBR Gene

Q0VD83-APOBR_HUMAN
Tissue specificity: Expressed in peripheral blood leukocytes > bone marrow = spleen > lymph node, and only faintly visible in appendix and thymus. Expressed in the brain, heart, kidney, liver, lung, pancreas, and placenta. Expressed primarily by reticuloendothelial cells: monocytes, macrophages, and endothelial cells. Expressed in atherosclerotic lesion foam cells.
genes like me logo Genes that share expression patterns with APOBR: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for APOBR Gene

Orthologs for APOBR Gene

This gene was present in the common ancestor of mammals.

Orthologs for APOBR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia APOBR 35
  • 77.03 (n)
  • 65.37 (a)
APOBR 36
  • 56 (a)
OneToOne
dog
(Canis familiaris)
Mammalia APOBR 35
  • 70.48 (n)
  • 56.52 (a)
APOBR 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Apobr 35
  • 66.1 (n)
  • 50.85 (a)
Apobr 16
Apobr 36
  • 48 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia APOBR 35
  • 98.39 (n)
  • 97.08 (a)
APOBR 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Apobr 35
  • 68.76 (n)
  • 53.67 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia APOBR 36
  • 52 (a)
OneToOne
Species with no ortholog for APOBR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for APOBR Gene

ENSEMBL:
Gene Tree for APOBR (if available)
TreeFam:
Gene Tree for APOBR (if available)

Paralogs for APOBR Gene

(1) SIMAP similar genes for APOBR Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with APOBR: view

No data available for Paralogs for APOBR Gene

Variants for APOBR Gene

Sequence variations from dbSNP and Humsavar for APOBR Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_042432 -

Structural Variations from Database of Genomic Variants (DGV) for APOBR Gene

Variant ID Type Subtype PubMed ID
dgv842e1 CNV Complex 17122850
dgv843e1 CNV Complex 17122850
nsv833180 CNV Loss 17160897
nsv905688 CNV Gain 21882294
nsv509608 CNV Insertion 20534489
nsv9415 CNV Gain 18304495

Variation tolerance for APOBR Gene

Residual Variation Intolerance Score: 93.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.88; 89.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for APOBR Gene

HapMap Linkage Disequilibrium report
APOBR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for APOBR Gene

Disorders for APOBR Gene

Relevant External Links for APOBR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
APOBR

No disorders were found for APOBR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for APOBR Gene

Publications for APOBR Gene

  1. A macrophage receptor for apolipoprotein B48: cloning, expression, and atherosclerosis. (PMID: 10852956) Brown M.L. … Gianturco S.H. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4 23 67
  2. Association of nucleotide variations in the apolipoprotein B48 receptor gene (APOB48R) with hypercholesterolemia. (PMID: 15830122) Fujita Y. … Emi M. (J. Hum. Genet. 2005) 3 23
  3. Analyses of non-synonymous obesity risk alleles in SH2B1 (rs7498665) and APOB48R (rs180743) in obese children and adolescents undergoing a 1-year lifestyle intervention. (PMID: 23519644) Volckmar A.L. … Hinney A. (Exp. Clin. Endocrinol. Diabetes 2013) 3
  4. Triglyceride-rich lipoprotein regulates APOB48 receptor gene expression in human THP-1 monocytes and macrophages. (PMID: 22190030) Bermudez B. … Muriana F.J. (J. Nutr. 2012) 3
  5. A high-fat meal promotes lipid-load and apolipoprotein B-48 receptor transcriptional activity in circulating monocytes. (PMID: 21367954) Varela L.M. … Muriana F.J. (Am. J. Clin. Nutr. 2011) 3

Products for APOBR Gene

Sources for APOBR Gene

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